Butein (BioDeep_00000000478)

   

natural product PANOMIX_OTCML-2023


代谢物信息卡片


2 inverted exclamation mark ,3,4,4 inverted exclamation mark -tetrahydroxy Chalcone

化学式: C15H12O5 (272.0684702)
中文名称: 紫柳花素, 紫铆花素, 紫铆因, 紫铆查尔酮
谱图信息: 最多检出来源 Viridiplantae(plant) 1.12%

分子结构信息

SMILES: C1(O)=CC=C(C(=O)/C=C/C2C=CC(O)=C(O)C=2)C(O)=C1
InChI: InChI=1S/C15H12O5/c16-10-3-4-11(14(19)8-10)12(17)5-1-9-2-6-13(18)15(20)7-9/h1-8,16,18-20H/b5-1+

描述信息

Butein is a chalcone that is (E)-chalcone bearing four additional hydroxy substituents at positions 2, 3, 4 and 4. It has a role as a tyrosine kinase inhibitor, an antioxidant, an EC 1.1.1.21 (aldehyde reductase) inhibitor, an antineoplastic agent, a geroprotector, a radiosensitizing agent, a hypoglycemic agent and a plant metabolite. It is a member of chalcones and a polyphenol.
Butein is a natural product found in Dahlia pinnata, Calanticaria bicolor, and other organisms with data available.
Butein is a flavonoid obtained from the seed of Cyclopia subternata. It is a specific protein tyrosine kinase inhibitor that induces apoptosis. (NCI)
See also: Semecarpus anacardium juice (part of).
A chalcone that is (E)-chalcone bearing four additional hydroxy substituents at positions 2, 3, 4 and 4.
C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor > C1967 - Tyrosine Kinase Inhibitor
Butein, also known as 2,3,4,4-tetrahydroxychalcone, is a member of the class of compounds known as 2-hydroxychalcones. 2-hydroxychalcones are organic compounds containing chalcone skeleton that carries a hydroxyl group at the 2-position. Thus, butein is considered to be a flavonoid lipid molecule. Butein is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). Butein is a bitter tasting compound found in broad bean, which makes butein a potential biomarker for the consumption of this food product. Butein is a chalcone of the chalconoids. It can be found in Toxicodendron vernicifluum (or formerly Rhus verniciflua), Dahlia, Butea (Butea monosperma) and Coreopsis It has antioxidative, aldose reductase and advanced glycation endproducts inhibitory effects. It is also a sirtuin-activating compound, a chemical compound having an effect on sirtuins, a group of enzymes that use NAD+ to remove acetyl groups from proteins. It turned out that buteins possess a high ability to inhibit aromatase process in the human body, for this reason, the use of these compounds in the treatment of breast cancer on the estrogen ground has been taken into account. The first attempts of sport pro-hormone supplementation with the use of buteins took place in Poland .
Butein is a cAMP-specific PDE inhibitor with an IC50 of 10.4 μM for PDE4[1]. Butein is a specific protein tyrosine kinase inhibitor with IC50s of 16 and 65 μM for EGFR and p60c-src in HepG2 cells[2]. Butein sensitizes HeLa cells to Cisplatin through AKT and ERK/p38 MAPK pathways by targeting FoxO3a[3]. Butein is a SIRT1 activator (STAC).
Butein is a cAMP-specific PDE inhibitor with an IC50 of 10.4 μM for PDE4[1]. Butein is a specific protein tyrosine kinase inhibitor with IC50s of 16 and 65 μM for EGFR and p60c-src in HepG2 cells[2]. Butein sensitizes HeLa cells to Cisplatin through AKT and ERK/p38 MAPK pathways by targeting FoxO3a[3]. Butein is a SIRT1 activator (STAC).

同义名列表

54 个代谢物同义名

2 inverted exclamation mark ,3,4,4 inverted exclamation mark -tetrahydroxy Chalcone; 2-Propen-1-one, 1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)-, (2E)-; 2-Propen-1-one,1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)-, (2E)-; 2-PROPEN-1-ONE, 1-(2,4-DIHYDROXYPHENYL)-3-(3,4-DIHYDROXYPHENYL)-, (E)-; (2E)-1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)prop-2-en-1-one; (2E)-1-(2,4-Dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)-2-propen-1-one; (E)-1-(2,4-Dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)-2-propen-1-one; (E)-1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)prop-2-en-1-one; 2-Propen-1-one, 1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)-; 2-Propen-1-one,1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)-; (E)-3-(3,4-Dihydroxy-phenyl)-1-(2,4-dihydroxy-phenyl)-propenone; 1-(2,4-Dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)-2-propen-1-one; 3-(3,4-Dihydroxy-phenyl)-1-(2,4-dihydroxy-phenyl)-propenone; Acrylophenone, 2,4-dihydroxy-3-(3,4-dihydroxyphenyl)-; Chalcone, 2,3,4,4-tetrahydroxy-(7CI,8CI); 2,3,4,4-Tetrahydroxychalcone; Butein; (E)-2,3,4,4-terahydroxychalcone; Chalcone, 2,3,4,4-tetrahydroxy-; ISOLIQUIRITIGENIN METABOLITE M4; TETRAHYDROXYCHALCONE, 3,4,2,4-; 2,3,4,4-tetrahydroxy Chalcone; 2,3,4,4-Tetrahydroxy-chalcone; 3,4,2,4-Tetrahydroxychalcone; 2,4,3,4-tetrahydroxychalcone; 2,3,4,4-tetrahydroxychalcone; 3,4,2,4-tetrahydroxychalone; 3,4,2,4-Tetrahydroxychalone; Butein, analytical standard; UNII-4WVS5M0LGF; Butein, solid; LAVENDUSTINC; HSCI1_000162; 4WVS5M0LGF; AC1NQY7L; Butein; 1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)prop-2-en-1-one; Chalcone, 2,3,4,4-tetrahydroxy- (7CI,8CI); 2′,3,4,4′-Tetrahydroxychalcone; 2′,4′,3,4-Tetrahydroxychalcone; 2,3,4,4-Tetrahydrochalcone; EINECS 207-659-5; NCGC00163519-01; MolMap_000005; NCI60_018489; AIDS-057944; B178_SIGMA; 21849-70-7; AIDS057944; ST5331397; NSC652892; 487-52-5; C08578; (E) -1- (2,4-Dihydroxyphenyl) -3- (3,4-dihydroxyphenyl) -2-propen-1-one; 2’,3,4,4’-tetrahydroxy Chalcone



数据库引用编号

26 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(1)

代谢反应

6 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(2)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(3)

COVID-19 Disease Map(0)

PathBank(1)

PharmGKB(0)

187 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mujeeba Rehman, Rishabh Chaudhary, Sonu Rajput, Vipul Agarwal, Arjun Singh Kaushik, Siddhi Srivastava, Sukriti Srivastava, Rohit Singh, Irfan Aziz, Sanjay Singh, Vikas Mishra. Butein ameliorates chronic stress induced atherosclerosis via targeting anti-inflammatory, anti-fibrotic and BDNF pathways. Physiology & behavior. 2023 Apr; 267(?):114207. doi: 10.1016/j.physbeh.2023.114207. [PMID: 37100219]
  • Somayeh Mahdinloo, Salar Hemmati, Hadi Valizadeh, Mohammad Mahmoudian, Javad Mahmoudi, Leyla Roshangar, Muhammad Sarfraz, Parvin Zakeri-Milani. Synthesis and preparation of vitamin A coupled butein-loaded solid lipid nanoparticles for liver fibrosis therapy in rats. International journal of pharmaceutics. 2022 Sep; 625(?):122063. doi: 10.1016/j.ijpharm.2022.122063. [PMID: 35964827]
  • Pei Zhang, Jiale Zhang, Huahong Quan, Pengtao Chen, Jingcheng Wang, Yuan Liang. Effects of butein on human osteosarcoma cell proliferation, apoptosis, and autophagy through oxidative stress. Human & experimental toxicology. 2022 Jan; 41(?):9603271221074346. doi: 10.1177/09603271221074346. [PMID: 35130734]
  • Peng Liu, Quanli Pan. Butein Inhibits Oxidative Stress Injury in Rats with Chronic Heart Failure via ERK/Nrf2 Signaling. Cardiovascular therapeutics. 2022; 2022(?):8684014. doi: 10.1155/2022/8684014. [PMID: 35069800]
  • Jaeyool Jang, Seo-Hyuk Chang, Dawoon Song, No-Joon Song, Saeroarum Han, Seungjun Oh, Ui Jeong Yun, Jee-Yin Ahn, Sukchan Lee, Jin-Mo Ku, Kye Won Park. Butein-Enriched Fractions of Butea monosperma (Lam.) Taub. Flower Decrease Weight Gains and Increase Energy Expenditure in High-Fat Diet-Induced Obese Mice. Journal of medicinal food. 2021 Dec; 24(12):1271-1279. doi: 10.1089/jmf.2021.k.0074. [PMID: 34847724]
  • Hardeep Singh Tuli, Ruchira Joshi, Diwakar Aggarwal, Ginpreet Kaur, Jagjit Kaur, Manoj Kumar, Nidarshana Chaturvedi Parashar, Md Asaduzzaman Khan, Katrin Sak. Molecular mechanisms underlying chemopreventive potential of butein: Current trends and future perspectives. Chemico-biological interactions. 2021 Dec; 350(?):109699. doi: 10.1016/j.cbi.2021.109699. [PMID: 34648814]
  • Mehmet Akif Ramazanoglu, Tuncay Toprak, Mehmet Remzi Erdem, Gulistan Gumrukcu, Hatice Kucuk, Feridun Sengor. Effects of butein on renal ischemia/reperfusion injury: An experimental study. Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica. 2020 Dec; 92(4):. doi: 10.4081/aiua.2020.4.335. [PMID: 33348962]
  • Renalison Farias-Pereira, Zhenyu Zhang, Cheon-Seok Park, Daeyoung Kim, Kee-Hong Kim, Yeonhwa Park. Butein inhibits lipogenesis in Caenorhabditis elegans. BioFactors (Oxford, England). 2020 Sep; 46(5):777-787. doi: 10.1002/biof.1667. [PMID: 32663368]
  • D Sathya Prabhu, V Devi Rajeswari. PPAR-Gamma as putative gene target involved in Butein mediated anti-diabetic effect. Molecular biology reports. 2020 Jul; 47(7):5273-5283. doi: 10.1007/s11033-020-05605-1. [PMID: 32642916]
  • Basem M Abdallah, Enas M Ali. Butein Promotes Lineage Commitment of Bone Marrow-Derived Stem Cells into Osteoblasts via Modulating ERK1/2 Signaling Pathways. Molecules (Basel, Switzerland). 2020 Apr; 25(8):. doi: 10.3390/molecules25081885. [PMID: 32325749]
  • Bianca Hemmeryckx, Christine Vranckx, Dries Bauters, H Roger Lijnen, Ilse Scroyen. Does butein affect adipogenesis?. Adipocyte. 2019 12; 8(1):209-222. doi: 10.1080/21623945.2019.1617619. [PMID: 31094273]
  • Miroslav Novakovic, Iris Djordjevic, Nina Todorovic, Snezana Trifunovic, Boban Andjelkovic, Boris Mandic, Milka Jadranin, Ivan Vuckovic, Vlatka Vajs, Slobodan Milosavljevic, Vele Tesevic. New aurone epoxide and auronolignan from the heartwood of Cotinus coggygria Scop. Natural product research. 2019 Oct; 33(19):2837-2844. doi: 10.1080/14786419.2018.1508141. [PMID: 30513208]
  • C Zhang, X Zong, Y Han. Effect of butein and glucose on oxidative stress and p38 activation marker in non-small cell lung cancer cell. Human & experimental toxicology. 2019 Oct; 38(10):1155-1167. doi: 10.1177/0960327119851250. [PMID: 31215238]
  • D Sathya Prabhu, V Devi Rajeswari. In vitro and in silico analyses of Vicia faba L. on Peroxisome proliferator-activated receptor gamma. Journal of cellular biochemistry. 2018 09; 119(9):7729-7737. doi: 10.1002/jcb.27123. [PMID: 29923224]
  • Ghedeir M Alshammari, Aristatile Balakrishnan, Thirunavukkarasu Chinnasamy. Butein protects the nonalcoholic fatty liver through mitochondrial reactive oxygen species attenuation in rats. BioFactors (Oxford, England). 2018 May; 44(3):289-298. doi: 10.1002/biof.1428. [PMID: 29672963]
  • Chie Ishikawa, Masachika Senba, Naoki Mori. Butein inhibits NF-κB, AP-1 and Akt activation in adult T-cell leukemia/lymphoma. International journal of oncology. 2017 Aug; 51(2):633-643. doi: 10.3892/ijo.2017.4026. [PMID: 28586006]
  • Tae Gyu Nam, Bong Han Lee, Hyo-Kyoung Choi, Ahmad Rois Mansur, Sang Gil Lee, Dae-Ok Kim. Rhus verniciflua Stokes Extract and Its Flavonoids Protect PC-12 Cells against H2O2-Induced Cytotoxicity. Journal of microbiology and biotechnology. 2017 Jun; 27(6):1090-1097. doi: 10.4014/jmb.1612.12018. [PMID: 28376611]
  • Ganesan Padmavathi, Nand Kishor Roy, Devivasha Bordoloi, Frank Arfuso, Srishti Mishra, Gautam Sethi, Anupam Bishayee, Ajaikumar B Kunnumakkara. Butein in health and disease: A comprehensive review. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2017 Feb; 25(?):118-127. doi: 10.1016/j.phymed.2016.12.002. [PMID: 28190465]
  • Hyeong Sim Choi, Min Kyoung Kim, Youn Kyung Choi, Yong Cheol Shin, Sung-Gook Cho, Seong-Gyu Ko. Rhus verniciflua Stokes (RVS) and butein induce apoptosis of paclitaxel-resistant SKOV-3/PAX ovarian cancer cells through inhibition of AKT phosphorylation. BMC complementary and alternative medicine. 2016 Apr; 16(?):122. doi: 10.1186/s12906-016-1103-3. [PMID: 27121110]
  • Christian Molitor, Stephan Gerhard Mauracher, Annette Rompel. Aurone synthase is a catechol oxidase with hydroxylase activity and provides insights into the mechanism of plant polyphenol oxidases. Proceedings of the National Academy of Sciences of the United States of America. 2016 Mar; 113(13):E1806-15. doi: 10.1073/pnas.1523575113. [PMID: 26976571]
  • Mahmut Toprak. Fluorescence study on the interaction of human serum albumin with Butein in liposomes. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2016 Feb; 154(?):108-113. doi: 10.1016/j.saa.2015.10.023. [PMID: 26519918]
  • Ziwei Song, Muthu K Shanmugam, Hanry Yu, Gautam Sethi. Butein and Its Role in Chronic Diseases. Advances in experimental medicine and biology. 2016; 928(?):419-433. doi: 10.1007/978-3-319-41334-1_17. [PMID: 27671826]
  • Cornelia Kaintz, Rupert L Mayer, Franz Jirsa, Heidi Halbwirth, Annette Rompel. Site-directed mutagenesis around the CuA site of a polyphenol oxidase from Coreopsis grandiflora (cgAUS1). FEBS letters. 2015 Mar; 589(7):789-97. doi: 10.1016/j.febslet.2015.02.009. [PMID: 25697959]
  • Pei-Yu Yang, Dan-Ning Hu, I-Ching Lin, Fu-Shing Liu. Butein Shows Cytotoxic Effects and Induces Apoptosis in Human Ovarian Cancer Cells. The American journal of Chinese medicine. 2015; 43(4):769-82. doi: 10.1142/s0192415x15500482. [PMID: 26119952]
  • Jun-Hyeong Lee, Mikyung Kim, Kyung-Hwa Chang, Cheol Yi Hong, Chun-Soo Na, Mi-Sook Dong, Dongho Lee, Moo-Yeol Lee. Antiplatelet effects of Rhus verniciflua stokes heartwood and its active constituents--fisetin, butein, and sulfuretin--in rats. Journal of medicinal food. 2015 Jan; 18(1):21-30. doi: 10.1089/jmf.2013.3116. [PMID: 25372471]
  • Qing Zhang, Jing-Li Liu, Xiao-Man Qi, Chun-Ting Qi, Qiang Yu. Inhibitory activities of Lignum Sappan extractives on growth and growth-related signaling of tumor cells. Chinese journal of natural medicines. 2014 Aug; 12(8):607-12. doi: 10.1016/s1875-5364(14)60092-3. [PMID: 25156286]
  • Myeong Hyeon Park, In Sook Kim, Sun-A Kim, Chun-Soo Na, Cheol Yi Hong, Mi-Sook Dong, Hye Hyun Yoo. Inhibitory effect of Rhus verniciflua Stokes extract on human aromatase activity; butin is its major bioactive component. Bioorganic & medicinal chemistry letters. 2014 Apr; 24(7):1730-3. doi: 10.1016/j.bmcl.2014.02.039. [PMID: 24630560]
  • Hai-tao Bian, Jun Zhao, Hua Huang, Qiao-li Yang, Yan Liu. [Chemical constituents from seeds of Sophora alopecuroides]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2014 Jan; 37(1):72-3. doi: ". [PMID: 25090709]
  • Chul Lee, Jin Woo Lee, Qinghao Jin, Dae Sik Jang, Sung-Joon Lee, Dongho Lee, Jin Tae Hong, Youngsoo Kim, Mi Kyeong Lee, Bang Yeon Hwang. Inhibitory constituents of the heartwood of Dalbergia odorifera on nitric oxide production in RAW 264.7 macrophages. Bioorganic & medicinal chemistry letters. 2013 Jul; 23(14):4263-6. doi: 10.1016/j.bmcl.2013.04.032. [PMID: 23743282]
  • No-Joon Song, Hyang-Jin Yoon, Ki Hyun Kim, So-Ra Jung, Woo-Seok Jang, Cho-Rong Seo, Young Min Lee, Dae-Hyuk Kweon, Joung-Woo Hong, Jeong-Soo Lee, Ki-Moon Park, Kang Ro Lee, Kye Won Park. Butein is a novel anti-adipogenic compound. Journal of lipid research. 2013 May; 54(5):1385-96. doi: 10.1194/jlr.m035576. [PMID: 23468131]
  • Dong-Sung Lee, Bin Li, Kyoung-Su Kim, Gil-Saeng Jeong, Eun-Cheol Kim, Youn-Chul Kim. Butein protects human dental pulp cells from hydrogen peroxide-induced oxidative toxicity via Nrf2 pathway-dependent heme oxygenase-1 expressions. Toxicology in vitro : an international journal published in association with BIBRA. 2013 Mar; 27(2):874-81. doi: 10.1016/j.tiv.2013.01.003. [PMID: 23318726]
  • Anuradha Sehrawat, Vijay Kumar. Butein imparts free radical scavenging, anti-oxidative and proapoptotic properties in the flower extracts of Butea monosperma. Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al. 2012 Aug; 36(2):63-71. doi: . [PMID: 23185781]
  • Namki Cho, Ji Hoon Choi, Heejung Yang, Eun Ju Jeong, Ki Yong Lee, Young Choong Kim, Sang Hyun Sung. Neuroprotective and anti-inflammatory effects of flavonoids isolated from Rhus verniciflua in neuronal HT22 and microglial BV2 cell lines. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2012 Jun; 50(6):1940-5. doi: 10.1016/j.fct.2012.03.052. [PMID: 22465834]
  • Naghma Khan, Vaqar M Adhami, Farrukh Afaq, Hasan Mukhtar. Butein induces apoptosis and inhibits prostate tumor growth in vitro and in vivo. Antioxidants & redox signaling. 2012 Jun; 16(11):1195-204. doi: 10.1089/ars.2011.4162. [PMID: 22114764]
  • Soon Jung Choi, Min Young Lee, Hyoung Jo, Soon Sung Lim, Sang Hoon Jung. Preparative isolation and purification of neuroprotective compounds from Rhus verniciflua by high speed counter-current chromatography. Biological & pharmaceutical bulletin. 2012; 35(4):559-67. doi: 10.1248/bpb.35.559. [PMID: 22466561]
  • Gabriele Multhoff, Jürgen Radons. Radiation, inflammation, and immune responses in cancer. Frontiers in oncology. 2012; 2(?):58. doi: 10.3389/fonc.2012.00058. [PMID: 22675673]
  • Woncheol Choi, Hyunsik Jung, Kyungsuk Kim, Sookyung Lee, Seongwoo Yoon, Jaehyun Park, Sehyun Kim, Seongha Cheon, Wankyo Eo, Sanghun Lee. Rhus verniciflua stokes against advanced cancer: a perspective from the Korean Integrative Cancer Center. Journal of biomedicine & biotechnology. 2012; 2012(?):874276. doi: 10.1155/2012/874276. [PMID: 22174564]
  • Lei Ma, Zhengyi Yang, Chenjing Li, Zhiyuan Zhu, Xu Shen, Lihong Hu. Design, synthesis and SAR study of hydroxychalcone inhibitors of human β-secretase (BACE1). Journal of enzyme inhibition and medicinal chemistry. 2011 Oct; 26(5):643-8. doi: 10.3109/14756366.2010.543420. [PMID: 21222511]
  • Sho Ohno, Munetaka Hosokawa, Atsushi Hoshino, Yoshikuni Kitamura, Yasumasa Morita, Kyeung-Ii Park, Akiko Nakashima, Ayumi Deguchi, Fumi Tatsuzawa, Motoaki Doi, Shigeru Iida, Susumu Yazawa. A bHLH transcription factor, DvIVS, is involved in regulation of anthocyanin synthesis in dahlia (Dahlia variabilis). Journal of experimental botany. 2011 Oct; 62(14):5105-16. doi: 10.1093/jxb/err216. [PMID: 21765172]
  • Soon-Sen Leow, Shamala Devi Sekaran, Kalyana Sundram, YewAi Tan, Ravigadevi Sambanthamurthi. Differential transcriptomic profiles effected by oil palm phenolics indicate novel health outcomes. BMC genomics. 2011 Aug; 12(?):432. doi: 10.1186/1471-2164-12-432. [PMID: 21864415]
  • Elizabeth A Mazzio, Fran Close, Karam F A Soliman. The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease. International journal of molecular sciences. 2011 Jan; 12(1):506-69. doi: 10.3390/ijms12010506. [PMID: 21340000]
  • Gil-Saeng Jeong, Dong-Sung Lee, Mi-Young Song, Byung-Hyun Park, Dae-Gill Kang, Ho-Sub Lee, Kang-Beom Kwon, Youn-Chul Kim. Butein from Rhus verniciflua protects pancreatic β cells against cytokine-induced toxicity mediated by inhibition of nitric oxide formation. Biological & pharmaceutical bulletin. 2011; 34(1):97-102. doi: 10.1248/bpb.34.97. [PMID: 21212525]
  • Karin Schlangen, Silvija Miosic, Jana Thill, Heidi Halbwirth. Cloning, functional expression, and characterization of a chalcone 3-hydroxylase from Cosmos sulphureus. Journal of experimental botany. 2010 Jul; 61(12):3451-9. doi: 10.1093/jxb/erq169. [PMID: 20566567]
  • R Gadekar, P K Singour, P K Chaurasiya, R S Pawar, U K Patil. A potential of some medicinal plants as an antiulcer agents. Pharmacognosy reviews. 2010 Jul; 4(8):136-46. doi: 10.4103/0973-7847.70906. [PMID: 22228953]
  • Zafar Rasheed, Nahid Akhtar, Abubakar Khan, Khursheed A Khan, Tariq M Haqqi. Butrin, isobutrin, and butein from medicinal plant Butea monosperma selectively inhibit nuclear factor-kappaB in activated human mast cells: suppression of tumor necrosis factor-alpha, interleukin (IL)-6, and IL-8. The Journal of pharmacology and experimental therapeutics. 2010 May; 333(2):354-63. doi: 10.1124/jpet.109.165209. [PMID: 20164300]
  • Dae-Geun Song, Joo Young Lee, Eun Ha Lee, Sang Hoon Jung, Chu Won Nho, Kwang Hyun Cha, Song Yi Koo, Cheol-Ho Pan. Inhibitory effects of polyphenols isolated from Rhus verniciflua on Aldo-keto reductase family 1 B10. BMB reports. 2010 Apr; 43(4):268-72. doi: 10.5483/bmbrep.2010.43.4.268. [PMID: 20423612]
  • E Paul Cherniack. The potential influence of plant polyphenols on the aging process. Forschende Komplementarmedizin (2006). 2010; 17(4):181-7. doi: 10.1159/000319143. [PMID: 20829595]
  • Zafar Rasheed, Nahid Akhtar, Tariq M Haqqi. Pomegranate extract inhibits the interleukin-1β-induced activation of MKK-3, p38α-MAPK and transcription factor RUNX-2 in human osteoarthritis chondrocytes. Arthritis research & therapy. 2010; 12(5):R195. doi: 10.1186/ar3166. [PMID: 20955562]
  • Mona Semalty, Ajay Semalty, Ashutosh Badola, Geeta Pant Joshi, M S M Rawat. Semecarpus anacardium Linn.: A review. Pharmacognosy reviews. 2010 Jan; 4(7):88-94. doi: 10.4103/0973-7847.65328. [PMID: 22228947]
  • Xiao-Yu Wang, Hai-Ming Shi, Li Zhang, Xiao-Bo Li. A new chalcone glycoside, a new tetrahydrofuranoid lignan, and antioxidative constituents from the stems and leaves of Viburnum propinquum. Planta medica. 2009 Sep; 75(11):1262-5. doi: 10.1055/s-0029-1185523. [PMID: 19330766]
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