Alantolactone (BioDeep_00000000468)

 

Secondary id: BioDeep_00001867506

human metabolite PANOMIX_OTCML-2023 Endogenous Antitumor activity natural product


代谢物信息卡片


Naphtho(2,3-b)furan-2(3H)-one, 3a,5,6,7,8,8a,9,9a-octahydro-5,8a-dimethyl-3-methylene-, (3aR-(3a alpha,5beta,8a beta,9a alpha))-

化学式: C15H20O2 (232.1463)
中文名称: 土木香内酯, 土木香脑, 阿兰内酯, 木香腦, 木香油內酯
谱图信息: 最多检出来源 Homo sapiens(lipidomics) 6.04%

分子结构信息

SMILES: C=C1C(=O)OC2CC3(C)CCCC(C)C3=CC12
InChI: InChI=1S/C15H20O2/c1-9-5-4-6-15(3)8-13-11(7-12(9)15)10(2)14(16)17-13/h7,9,11,13H,2,4-6,8H2,1,3H3

描述信息

Alantolactone is a sesquiterpene lactone that is 3a,5,6,7,8,8a,9,9a-octahydronaphtho[2,3-b]furan-2-one bearing two methyl substituents at positions 5 and 8a as well as a methylidene substituent at position 3. It has a role as a plant metabolite, an apoptosis inducer and an antineoplastic agent. It is a sesquiterpene lactone, a naphthofuran and an olefinic compound.
Alantolactone is a natural product found in Eupatorium cannabinum, Pentanema britannicum, and other organisms with data available.
Alantolactone is found in herbs and spices. Alantolactone is a constituent of Inula helenium (elecampane)
Constituent of Inula helenium (elecampane). Alantolactone is found in herbs and spices.
Alantolactone is a selective STAT3 inhibitor, with potent anticancer activity. Alantolactone induces apoptosis in cancer[1][2][3].
Alantolactone is a selective STAT3 inhibitor, with potent anticancer activity. Alantolactone induces apoptosis in cancer[1][2][3].

同义名列表

42 个代谢物同义名

Naphtho(2,3-b)furan-2(3H)-one, 3a,5,6,7,8,8a,9,9a-octahydro-5,8a-dimethyl-3-methylene-, (3aR-(3a alpha,5beta,8a beta,9a alpha))-; [3aR-(3a alpha,5 beta,8a beta,9a alpha)]-3a,5,6,7,8,8a,9,9a-Octahydro-5,8a-dimethyl-3-methylenenaphtho[2,3-b]furan-2(3H)-one; (3AR-(3aalpha,5beta,8abeta,9aalpha))-3a,5,6,7,8,8a,9,9a-octahydro-5,8a-dimethyl-3-methylenenaphtho(2,3-b)furan-2(3H)-one; Naphtho[2, 3a,5,6,7,8,8a,9,9a-octahydro-5,8a-dimethyl-3-methylene-, [3aR-(3a.alpha.,5.beta.,8a.beta.,9a.alpha.)]-; Naphtho[2,3-b]furan-2(3H)-one, 3a,5,6,7,8,8a,9,9a-octahydro-5,8a-dimethyl-3-methylene-, (3aR,5S,8aR,9aR)-; Naphtho[2,3-b]furan-2(3H)-one,3a,5,6,7,8,8a,9,9a-octahydro-5,8a-dimethyl-3-methylene-,(3aR,5S,8aR,9aR)-; (3aR,5S,8aR,9aR)-5,8a-dimethyl-3-methylidene-3a,5,6,7,8,8a,9,9a-octahydronaphtho[2,3-b]furan-2(3H)-one; (3aR,5S,8aR,9aR)-3a,5,6,7,8,8a,9,9a-Octahydro-5,8a-dimethyl-3-methylenenaphtho[2,3-b]furan-2(3H)-one; (3aR,5S,8aR,9aR)-5,8a-Dimethyl-3-methylene-3,3a,6,7,8,8a,9,9a-octahydronaphtho[2,3-b]furan-2(5H)-one; (3aR,5S,8aR,9aR)-5,8a-dimethyl-3-methylene-5,6,7,8,9,9a-hexahydro-3aH-benzo[f]benzofuran-2-one; 5,8a-dimethyl-3-methylidene-2H,3H,3aH,5H,6H,7H,8H,8aH,9H,9aH-naphtho[2,3-b]furan-2-one; 4alphaH-Eudesma-5,11(13)-dien-12-oic acid, 8beta-hydroxy-, gamma-lactone; 8.BETA.-HYDROXY-4.ALPHA.H-EUDESM-5-EN-12-OIC ACID .GAMMA.-LACTONE; 4.alpha.H-Eudesma-5, 8.beta.-hydroxy-, .gamma.-lactone; (+)-Alantolactone; Alant camphor; Inula camphor; Alantolactone, >=98\\% (HPLC); ALANTOLACTONE [MI]; Elecampane camphor; (+)-Alantolactone; Alantic anhydride; Spectrum4_001772; Spectrum5_000383; Spectrum3_001358; Spectrum2_000297; UNII-M7GSN5Q1M6; BOHLMANN K2631; Inula camphor; Alant camphor; Alantolactone; KBio3_002395; KBio2_003345; KBio2_005913; KBio2_000777; NCI60_042073; Alantcamphor; M7GSN5Q1M6; Helenine?; AI3-31147; helenine; helenin; Eupatal; Alantolactone



数据库引用编号

28 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

136 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 ANXA5, BCL2, CASP3, CASP9, CDH2, CTNNB1, MAPK14, MAPK8, PIK3CA, PTGS2, STAT3, VIM
Peripheral membrane protein 3 ANXA5, GORASP1, PTGS2
Endoplasmic reticulum membrane 2 BCL2, PTGS2
Nucleus 9 BCL2, CASP3, CASP9, CTNNB1, GABPA, MAPK14, MAPK8, PARP1, STAT3
cytosol 11 ANXA5, BCL2, CASP3, CASP9, CTNNB1, MAPK14, MAPK8, PARP1, PIK3CA, STAT3, VIM
nuclear body 1 PARP1
phagocytic vesicle 1 VIM
centrosome 1 CTNNB1
nucleoplasm 7 CASP3, CTNNB1, GABPA, MAPK14, MAPK8, PARP1, STAT3
RNA polymerase II transcription regulator complex 1 STAT3
Cell membrane 4 CDH2, CTNNB1, TNF, VIM
Cytoplasmic side 1 GORASP1
lamellipodium 3 CDH2, CTNNB1, PIK3CA
Golgi apparatus membrane 1 GORASP1
Synapse 2 CTNNB1, MAPK8
cell cortex 1 CTNNB1
cell junction 2 CDH2, CTNNB1
cell surface 2 CDH2, TNF
glutamatergic synapse 3 CASP3, CTNNB1, MAPK14
Golgi apparatus 1 GORASP1
Golgi membrane 1 GORASP1
neuronal cell body 2 CASP3, TNF
presynaptic membrane 1 CTNNB1
sarcolemma 2 ANXA5, CDH2
Cytoplasm, cytosol 1 PARP1
plasma membrane 7 CDH2, CTNNB1, IFNLR1, PIK3CA, STAT3, TNF, VIM
Membrane 6 ANXA5, BCL2, CDH2, CTNNB1, IFNLR1, PARP1
apical plasma membrane 1 CDH2
axon 3 CCK, MAPK8, VIM
basolateral plasma membrane 2 CDH2, CTNNB1
caveola 1 PTGS2
extracellular exosome 3 ANXA5, CTNNB1, VIM
endoplasmic reticulum 2 BCL2, PTGS2
extracellular space 4 CCK, CXCL8, IL6, TNF
perinuclear region of cytoplasm 2 CTNNB1, PIK3CA
Schaffer collateral - CA1 synapse 1 CTNNB1
adherens junction 2 CDH2, CTNNB1
apicolateral plasma membrane 2 CDH2, CTNNB1
bicellular tight junction 1 CTNNB1
intercalated disc 2 CDH2, PIK3CA
mitochondrion 4 BCL2, CASP9, MAPK14, PARP1
protein-containing complex 5 BCL2, CASP9, CTNNB1, PARP1, PTGS2
Microsome membrane 1 PTGS2
postsynaptic density 2 CASP3, CDH2
Single-pass type I membrane protein 2 CDH2, IFNLR1
Secreted 3 CCK, CXCL8, IL6
extracellular region 6 ANXA5, CCK, CXCL8, IL6, MAPK14, TNF
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
transcription regulator complex 3 CTNNB1, PARP1, STAT3
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 2 ANXA5, TNF
Z disc 1 CTNNB1
beta-catenin destruction complex 1 CTNNB1
nucleolus 1 PARP1
Wnt signalosome 1 CTNNB1
apical part of cell 2 CDH2, CTNNB1
cell-cell junction 2 CDH2, CTNNB1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
postsynaptic membrane 1 CTNNB1
presynaptic active zone membrane 1 CDH2
Cell membrane, sarcolemma 1 CDH2
Membrane raft 1 TNF
pore complex 1 BCL2
Cytoplasm, cytoskeleton 2 CTNNB1, VIM
focal adhesion 4 ANXA5, CDH2, CTNNB1, VIM
cis-Golgi network 1 GORASP1
Cell junction, adherens junction 2 CDH2, CTNNB1
flotillin complex 1 CTNNB1
Peroxisome 1 VIM
collagen-containing extracellular matrix 2 ANXA5, CDH2
fascia adherens 2 CDH2, CTNNB1
intermediate filament 1 VIM
lateral plasma membrane 1 CTNNB1
nuclear speck 1 MAPK14
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Zymogen granule membrane 1 ANXA5
neuron projection 3 CDH2, PTGS2, VIM
chromatin 3 GABPA, PARP1, STAT3
cell leading edge 1 VIM
phagocytic cup 1 TNF
cell periphery 1 CTNNB1
Chromosome 1 PARP1
cytoskeleton 1 VIM
Cytoplasm, cytoskeleton, cilium basal body 1 CTNNB1
Nucleus, nucleolus 1 PARP1
spindle pole 2 CTNNB1, MAPK14
nuclear replication fork 1 PARP1
chromosome, telomeric region 1 PARP1
postsynaptic density, intracellular component 1 CTNNB1
microvillus membrane 1 CTNNB1
site of double-strand break 1 PARP1
nuclear envelope 1 PARP1
Endomembrane system 1 CTNNB1
microtubule organizing center 1 VIM
euchromatin 1 CTNNB1
myelin sheath 1 BCL2
intermediate filament cytoskeleton 1 VIM
plasma membrane raft 1 CDH2
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 1 MAPK14
endoplasmic reticulum lumen 3 CDH2, IL6, PTGS2
nuclear matrix 1 VIM
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
beta-catenin-TCF complex 1 CTNNB1
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 GORASP1
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
Nucleus matrix 1 VIM
apoptosome 1 CASP9
presynaptic active zone cytoplasmic component 1 CTNNB1
vesicle membrane 1 ANXA5
protein-DNA complex 2 CTNNB1, PARP1
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
postsynaptic specialization membrane 1 CDH2
Cell junction, desmosome 1 CDH2
desmosome 1 CDH2
catenin complex 2 CDH2, CTNNB1
site of DNA damage 1 PARP1
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
interleukin-6 receptor complex 1 IL6
endothelial microparticle 1 ANXA5
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm 1 PARP1
BAD-BCL-2 complex 1 BCL2
beta-catenin-TCF7L2 complex 1 CTNNB1
beta-catenin-ICAT complex 1 CTNNB1
Scrib-APC-beta-catenin complex 1 CTNNB1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
caspase complex 1 CASP9
interleukin-28 receptor complex 1 IFNLR1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Zhi-E Fang, Yan Wang, Shuyi Bian, Shuanglin Qin, Huanying Zhao, Jincai Wen, Tingting Liu, Lutong Ren, Qiang Li, Wei Shi, Jia Zhao, Huijie Yang, Rui Peng, Qin Wang, Zhaofang Bai, Guang Xu. Helenine blocks NLRP3 activation by disrupting the NEK7-NLRP3 interaction and ameliorates inflammatory diseases. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jan; 122(?):155159. doi: 10.1016/j.phymed.2023.155159. [PMID: 37931457]
  • Yueyue Sun, Mengnan Yang, Shujun Li, Ying Hu, Biao Yang, Xu Li, Rong Yan, Kesheng Dai. Alantolactone induces platelet apoptosis by activating the Akt pathway. Platelets. 2023 Feb; ?(?):2173505. doi: 10.1080/09537104.2023.2173505. [PMID: 36813739]
  • Weifeng Li, Haowen Xu, Jingjing Shao, Jiahao Chen, Yimin Lin, Zhiwei Zheng, Yi Wang, Wu Luo, Guang Liang. Discovery of alantolactone as a naturally occurring NLRP3 inhibitor to alleviate NLRP3-driven inflammatory diseases in mice. British journal of pharmacology. 2023 Jan; ?(?):. doi: 10.1111/bph.16036. [PMID: 36668704]
  • Yiqun Hu, Qingliang Wen, Yefeng Cai, Yunye Liu, Wenli Ma, Qinglin Li, Fahuan Song, Yawen Guo, Lei Zhu, Jingyan Ge, Qian Zeng, Jiahui Wang, Changtian Yin, Guowan Zheng, Minghua Ge. Alantolactone induces concurrent apoptosis and GSDME-dependent pyroptosis of anaplastic thyroid cancer through ROS mitochondria-dependent caspase pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Jan; 108(?):154528. doi: 10.1016/j.phymed.2022.154528. [PMID: 36343549]
  • Syed Mudassir Jeelani, Mohd Shahnawaz, Ajai Prakash Gupta, Surrinder K Lattoo. Phytochemical Diversity in Relation to Cytogenetic Variability in Inula racemosa Hook.f., an Endangered Medicinal Plant of Himalayas. Chemistry & biodiversity. 2022 Dec; 19(12):e202200486. doi: 10.1002/cbdv.202200486. [PMID: 36263992]
  • Romit Seth, Amna Devi, Balraj Sharma, Mamta Masand, Gopal Singh, Poonam Pal, Ashlesha Holkar, Shikha Sharma, Vishal Sharma, Shivanti Negi, Ram Kumar Sharma. An Integrative Transcriptional Network Revealed Spatial Molecular Interplay Underlying Alantolactone and Inulin Biosynthesis in Inula racemosa Hook f. International journal of molecular sciences. 2022 Sep; 23(19):. doi: 10.3390/ijms231911213. [PMID: 36232516]
  • Yeon-Seop Jung, Yun-Jeong Jeong, Joung-Hee Kim, Chang-Hwan Jeon, Syng-Ook Lee. Elecampane (Inula helenium) Root Extract and Its Major Sesquiterpene Lactone, Alantolactone, Inhibit Adipogenesis of 3T3-L1 Preadipocytes. Molecules (Basel, Switzerland). 2022 Jul; 27(15):. doi: 10.3390/molecules27154765. [PMID: 35897937]
  • Zhijian Luo, Yantao Luo, Xiaoling Liang, Qingyang Lyu, Fanliang Meng, Xuncai Chen, Yupeng Wang, Weiyi Fang, Aimin Li, Dongfang Zhou. Alantolactone-Loaded Pegylated Prodrug Nanocarriers for Synergistic Treatment of Cisplatin-Resistant Ovarian Cancer via Reactivating Mitochondrial Apoptotic Pathway. ACS biomaterials science & engineering. 2022 06; 8(6):2526-2536. doi: 10.1021/acsbiomaterials.2c00316. [PMID: 35612599]
  • Qiang Shen, Ji-Xia Kuang, Chun-Xiao Miao, Wan-Li Zhang, Yi-Wei Li, Xiong-Wen Zhang, Xuan Liu. Alantolactone ameliorates cancer cachexia-associated muscle atrophy mainly by inhibiting the STAT3 signaling pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Jan; 95(?):153858. doi: 10.1016/j.phymed.2021.153858. [PMID: 34861585]
  • Miaomiao Liu, Panpan Liu, Bin Zheng, Yu Liu, Li Li, Xue Han, Yangshuang Liu, Li Chu. Cardioprotective effects of alantolactone on isoproterenol-induced cardiac injury and cobalt chloride-induced cardiomyocyte injury. International journal of immunopathology and pharmacology. 2022 Jan; 36(?):20587384211051993. doi: 10.1177/20587384211051993. [PMID: 34986670]
  • Feng Zhou, Zhenzhi Wang, Kang Xiong, Meiling Zhang, Yuan Wang, Maode Wang. Alantolactone reduced neuron injury via activating PI3K/Akt signaling pathway after subarachnoid hemorrhage in rats. PloS one. 2022; 17(6):e0270410. doi: 10.1371/journal.pone.0270410. [PMID: 35749405]
  • Xin Liu, Lijuan Bian, Xiaoqin Duan, Xinming Zhuang, Yujie Sui, Longfei Yang. Alantolactone: A sesquiterpene lactone with diverse pharmacological effects. Chemical biology & drug design. 2021 12; 98(6):1131-1145. doi: 10.1111/cbdd.13972. [PMID: 34624172]
  • Yijing Ren, Cheng Lv, Jing Zhang, Beibei Zhang, Bei Yue, Xiaoping Luo, Zhilun Yu, Hao Wang, Junyu Ren, Zhengtao Wang, Wei Dou. Alantolactone exhibits antiproliferative and apoptosis-promoting properties in colon cancer model via activation of the MAPK-JNK/c-Jun signaling pathway. Molecular and cellular biochemistry. 2021 Dec; 476(12):4387-4403. doi: 10.1007/s11010-021-04247-6. [PMID: 34460036]
  • Xiaodong Sun, Hongxia Xu, Tianyu Dai, Lixia Xie, Qiang Zhao, Xincai Hao, Yan Sun, Xuanbin Wang, Nan Jiang, Ming Sang. Alantolactone inhibits cervical cancer progression by downregulating BMI1. Scientific reports. 2021 04; 11(1):9251. doi: 10.1038/s41598-021-87781-z. [PMID: 33927214]
  • Y Y Yan, Q Zhang, B Zhang, B Yang, N M Lin. Active ingredients of Inula helenium L. exhibits similar anti-cancer effects as isoalantolactone in pancreatic cancer cells. Natural product research. 2020 Sep; 34(17):2539-2544. doi: 10.1080/14786419.2018.1543676. [PMID: 30661396]
  • Tomáš Zárybnický, Petra Matoušková, Lenka Skálová, Iva Boušová. The Hepatotoxicity of Alantolactone and Germacrone: Their Influence on Cholesterol and Lipid Metabolism in Differentiated HepaRG Cells. Nutrients. 2020 Jun; 12(6):. doi: 10.3390/nu12061720. [PMID: 32521813]
  • Yu Zhu, Yuanliang Ling, Xiao'ai Wang. Alantolactone mitigates renal injury induced by diabetes via inhibition of high glucose-mediated inflammatory response and macrophage infiltration. Immunopharmacology and immunotoxicology. 2020 Apr; 42(2):84-92. doi: 10.1080/08923973.2020.1725039. [PMID: 32064988]
  • Barbara Gierlikowska, Wojciech Gierlikowski, Katarzyna Bekier, Krystyna Skalicka-Woźniak, Monika E Czerwińska, Anna K Kiss. Inula helenium and Grindelia squarrosa as a source of compounds with anti-inflammatory activity in human neutrophils and cultured human respiratory epithelium. Journal of ethnopharmacology. 2020 Mar; 249(?):112311. doi: 10.1016/j.jep.2019.112311. [PMID: 31644941]
  • Xing Kang, Hijuan Wang, Yanwei Li, Ying Xiao, Lili Zhao, Tingting Zhang, Shaohe Zhou, Xiaolun Zhou, Yi Li, Zhexing Shou, Chao Chen, Bin Li. Alantolactone induces apoptosis through ROS-mediated AKT pathway and inhibition of PINK1-mediated mitophagy in human HepG2 cells. Artificial cells, nanomedicine, and biotechnology. 2019 Dec; 47(1):1961-1970. doi: 10.1080/21691401.2019.1593854. [PMID: 31116036]
  • Jing Zhang, Limei Shen, Xiang Li, Wantong Song, Yun Liu, Leaf Huang. Nanoformulated Codelivery of Quercetin and Alantolactone Promotes an Antitumor Response through Synergistic Immunogenic Cell Death for Microsatellite-Stable Colorectal Cancer. ACS nano. 2019 11; 13(11):12511-12524. doi: 10.1021/acsnano.9b02875. [PMID: 31664821]
  • Yijing Ren, Bei Yue, Gaiyan Ren, Zhilun Yu, Xiaoping Luo, Aning Sun, Jingjing Zhang, Mengqing Han, Zhengtao Wang, Wei Dou. Activation of PXR by alantolactone ameliorates DSS-induced experimental colitis via suppressing NF-κB signaling pathway. Scientific reports. 2019 11; 9(1):16636. doi: 10.1038/s41598-019-53305-z. [PMID: 31719637]
  • Yibing Zhang, Yong Zhao, Yongwang Ran, Jianyou Guo, Haifeng Cui, Sha Liu. Alantolactone exhibits selective antitumor effects in HELA human cervical cancer cells by inhibiting cell migration and invasion, G2/M cell cycle arrest, mitochondrial mediated apoptosis and targeting Nf-kB signalling pathway. Journal of B.U.ON. : official journal of the Balkan Union of Oncology. 2019 Nov; 24(6):2310-2315. doi: . [PMID: 31983099]
  • Renjie Xu, Ying Peng, Mengyue Wang, Xiaobo Li. Intestinal Absorption of Isoalantolactone and Alantolactone, Two Sesquiterpene Lactones from Radix Inulae, Using Caco-2 Cells. European journal of drug metabolism and pharmacokinetics. 2019 Apr; 44(2):295-303. doi: 10.1007/s13318-018-0510-x. [PMID: 30209793]
  • Meiting Yang, Hanhan Zhao, Huihan Ai, Hongbin Zhu, Shuyue Wang, Yongli Bao, Yuxin Li. Alantolactone suppresses APOC3 expression and alters lipid homeostasis in L02 liver cells. European journal of pharmacology. 2018 Jun; 828(?):60-66. doi: 10.1016/j.ejphar.2018.03.021. [PMID: 29555504]
  • Bo-Kyung Lee, Soo-Jin Park, So-Yeon Nam, Saeromi Kang, Jin Hwang, Seung-Jin Lee, Dong-Soon Im. Anti-allergic effects of sesquiterpene lactones from Saussurea costus (Falc.) Lipsch. determined using in vivo and in vitro experiments. Journal of ethnopharmacology. 2018 Mar; 213(?):256-261. doi: 10.1016/j.jep.2017.11.018. [PMID: 29158156]
  • Li Cui, Weiquan Bu, Jie Song, Liang Feng, Tingting Xu, Dan Liu, Wenbo Ding, Jianhua Wang, Changyang Li, Binge Ma, Yi Luo, Ziyu Jiang, Chengcheng Wang, Juan Chen, Jian Hou, Hongmei Yan, Lei Yang, Xiaobin Jia. Apoptosis induction by alantolactone in breast cancer MDA-MB-231 cells through reactive oxygen species-mediated mitochondrion-dependent pathway. Archives of pharmacal research. 2018 Mar; 41(3):299-313. doi: 10.1007/s12272-017-0990-2. [PMID: 29214600]
  • Bailun Zhou, Ji Ye, Niao Yang, Liping Chen, Zhiguo Zhuo, Ling Mao, Qun Liu, Gongcai Lan, Jing Ning, Guangbo Ge, Ling Yang, Yunheng Shen, Shumei Wang, Weidong Zhang. Metabolism and pharmacokinetics of alantolactone and isoalantolactone in rats: Thiol conjugation as a potential metabolic pathway. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2018 Jan; 1072(?):370-378. doi: 10.1016/j.jchromb.2017.11.039. [PMID: 29223921]
  • Lin Chen, Jian-Ping Zhang, Xin Liu, Jiang-Jiang Tang, Ping Xiang, Xing-Ming Ma. Semisynthesis, an Anti-Inflammatory Effect of Derivatives of 1β-Hydroxy Alantolactone from Inula britannica. Molecules (Basel, Switzerland). 2017 Oct; 22(11):. doi: 10.3390/molecules22111835. [PMID: 29077042]
  • Yang Yang, Rui Tu, Wenji Sun, Zhongliang Zhu, Yongmin Zhang. Silver perchlorate in the mobile phase for rapid separation and determination of a pair of positional isomers in Inula racemosa Hook.f. with RP-HPLC. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2017 Sep; 1063(?):25-30. doi: 10.1016/j.jchromb.2017.08.013. [PMID: 28837869]
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