Phosphoribosyl pyrophosphate (BioDeep_00000415791)
Main id: BioDeep_00000001269
代谢物信息卡片
ALPHA-PHOSPHORIBOSYLPYROphosphORIC ACID
化学式: C5H13O14P3 (389.9518)
中文名称: 磷酸核糖焦磷酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(C1C(C(C(O1)OP(=O)(O)OP(=O)(O)O)O)O)OP(=O)(O)O
InChI: InChI=1S/C5H13O14P3/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13)/t2-,3-,4-,5-/m1/s1
描述信息
COVID info from COVID-19 Disease Map
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:17111
- KEGG: C00119
- PubChem: 7339
- DrugBank: DB01632
- MeSH: Phosphoribosyl Pyrophosphate
- CAS: 7540-64-9
- MoNA: MoNA024072
- MoNA: MoNA024054
- PubChem: 3419
- KNApSAcK: C00007296
- PDB-CCD: PRP
- 3DMET: B01164
- NIKKAJI: J40.073D
- RefMet: Phosphoribosyl pyrophosphate
分类词条
相关代谢途径
BioCyc(13)
- purine and pyrimidine metabolism
- salvage pathways of purine nucleosides
- salvage pathways of adenine, hypoxanthine, and their nucleosides
- purine nucleotides de novo biosynthesis I
- superpathway of histidine, purine, and pyrimidine biosynthesis
- purine nucleotides de novo biosynthesis II
- salvage pathways of purine nucleosides I
- tryptophan degradation via kynurenine
- NAD biosynthesis (from tryptophan)
- NAD biosynthesis II (from tryptophan)
- pyridine nucleotide cycling
- superpathway of histidine, purine and pyrimidine biosynthesis
- salvage pathways of guanine, xanthine, and their nucleosides
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
3 个相关的物种来源信息
- 3702 - Arabidopsis thaliana: 10.1111/TPJ.14594
- 3039 - Euglena gracilis: 10.3389/FBIOE.2021.662655
- 9606 - Homo sapiens: 10.1007/S11306-016-1051-4
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Eziuche A Ugbogu, Lilian M Schweizer, Michael Schweizer. Contribution of Model Organisms to Investigating the Far-Reaching Consequences of PRPP Metabolism on Human Health and Well-Being.
Cells.
2022 06; 11(12):. doi:
10.3390/cells11121909. [PMID: 35741038] - Qianqian Tian, Wanbo Li, Jiacheng Li, Yao Xiao, Baolan Wu, Zhiyong Wang, Fang Han. Towards Understanding PRPS1 as a Molecular Player in Immune Response in Yellow Drum (Nibea albiflora).
International journal of molecular sciences.
2022 Jun; 23(12):. doi:
10.3390/ijms23126475. [PMID: 35742917] - Piero L Ipata, Marcella Camici, Vanna Micheli, Maria G Tozz. Metabolic network of nucleosides in the brain.
Current topics in medicinal chemistry.
2011; 11(8):909-22. doi:
10.2174/156802611795347555. [PMID: 21401502] - Beata A Wolucka. Biosynthesis of D-arabinose in mycobacteria - a novel bacterial pathway with implications for antimycobacterial therapy.
The FEBS journal.
2008 Jun; 275(11):2691-711. doi:
10.1111/j.1742-4658.2008.06395.x. [PMID: 18422659] - Hairong Huang, Stefan Berg, John S Spencer, Danny Vereecke, Wim D'Haeze, Marcelle Holsters, Michael R McNeil. Identification of amino acids and domains required for catalytic activity of DPPR synthase, a cell wall biosynthetic enzyme of Mycobacterium tuberculosis.
Microbiology (Reading, England).
2008 Mar; 154(Pt 3):736-743. doi:
10.1099/mic.0.2007/013532-0. [PMID: 18310020] - Hairong Huang, Michael S Scherman, Wim D'Haeze, Danny Vereecke, Marcelle Holsters, Dean C Crick, Michael R McNeil. Identification and active expression of the Mycobacterium tuberculosis gene encoding 5-phospho-{alpha}-d-ribose-1-diphosphate: decaprenyl-phosphate 5-phosphoribosyltransferase, the first enzyme committed to decaprenylphosphoryl-d-arabinose synthesis.
The Journal of biological chemistry.
2005 Jul; 280(26):24539-43. doi:
10.1074/jbc.m504068200. [PMID: 15878857] - Frederic D Sigoillot, David R Evans, Hedeel I Guy. Growth-dependent regulation of mammalian pyrimidine biosynthesis by the protein kinase A and MAPK signaling cascades.
The Journal of biological chemistry.
2002 May; 277(18):15745-51. doi:
10.1074/jbc.m201112200. [PMID: 11872754] - Roger Schneiter, Andrew T Carter, Yolanda Hernando, Günther Zellnig, Lilian M Schweizer, Michael Schweizer. The importance of the five phosphoribosyl-pyrophosphate synthetase (Prs) gene products of Saccharomyces cerevisiae in the maintenance of cell integrity and the subcellular localization of Prs1p.
Microbiology (Reading, England).
2000 Dec; 146 Pt 12(?):3269-3278. doi:
10.1099/00221287-146-12-3269. [PMID: 11101685] - E Zoref-Shani, S Feinstein, Y Frishberg, Y Bromberg, O Sperling. Kelley-Seegmiller syndrome due to a unique variant of hypoxanthine-guanine phosphoribosyltransferase: reduced affinity for 5-phosphoribosyl-1-pyrophosphate manifested only at low, physiological substrate concentrations.
Biochimica et biophysica acta.
2000 Feb; 1500(2):197-203. doi:
10.1016/s0925-4439(99)00103-9. [PMID: 10657589] - R Curto, E O Voit, A Sorribas, M Cascante. Validation and steady-state analysis of a power-law model of purine metabolism in man.
The Biochemical journal.
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Biochemistry and molecular biology international.
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1993 Apr; 45(8):1695-701. doi:
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Diabetes.
1992 Nov; 41(11):1429-35. doi:
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Biochemical medicine and metabolic biology.
1991 Oct; 46(2):215-25. doi:
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European journal of haematology.
1991 Sep; 47(3):213-8. doi:
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Advances in experimental medicine and biology.
1991; 309B(?):341-3. doi:
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Pharmaceutical research.
1989 Oct; 6(10):863-6. doi:
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Journal of developmental physiology.
1989 Sep; 12(3):135-43. doi:
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Cardiovascular research.
1989 Aug; 23(8):702-8. doi:
10.1093/cvr/23.8.702. [PMID: 2480849] - M Tatibana, S Ishijima, K Kita, T Ishizuka, N Suzuki. Early mitogenic stimulation of metabolic flux through phosphoribosyl pyrophosphate into nucleotides in Swiss 3T3 cells and requirement of external magnesium for the response.
Advances in enzyme regulation.
1989; 28(?):147-66. doi:
10.1016/0065-2571(89)90069-1. [PMID: 2483026] - Y M Choy, W P Lam, K P Fung. Intracellular phosphoribosyl diphosphate level and glucose carrier in Ehrlich ascites tumour cells during tumour growth and diabetes in tumour-bearing mice.
Cancer letters.
1988 Sep; 42(1-2):43-8. doi:
10.1016/0304-3835(88)90237-6. [PMID: 2460217] - K A Steer, M Sochor, S Kunjara, W Doepfner, P McLean. The effect of a somatostatin analogue (SMS 201-995, Sandostatin) on the concentration of phosphoribosyl pyrophosphate and the activity of the pentose phosphate pathway in the early renal hypertrophy of experimental diabetes in the rat.
Biochemical medicine and metabolic biology.
1988 Apr; 39(2):226-33. doi:
10.1016/0885-4505(88)90080-1. [PMID: 2454125] - M A Kane, E Roth, G Raptis, C Schreiber, S Waxman. Effect of intracellular folate concentration on the modulation of 5-fluorouracil cytotoxicity by the elevation of phosphoribosylpyrophosphate in cultured human KB cells.
Cancer research.
1987 Dec; 47(24 Pt 1):6444-50. doi:
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Cell biochemistry and function.
1987 Oct; 5(4):289-300. doi:
10.1002/cbf.290050408. [PMID: 2445500] - J Ghitis, C Schreiber, S Waxman. Phosphate-induced phosphoribosylpyrophosphate elevations to assess deranged folate and purine nucleotide metabolism.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.).
1987 Oct; 186(1):90-5. doi:
10.3181/00379727-186-42590. [PMID: 2442765] - K K Harden, J L Robinson. Deficiency of UMP synthase in dairy cattle: a model for hereditary orotic aciduria.
Journal of inherited metabolic disease.
1987; 10(3):201-9. doi:
10.1007/bf01800062. [PMID: 2448544] - S Kunjara, M Sochor, A L Greenbaum, P McLean. Concentration of phosphoribosyl pyrophosphate in renal hypertrophy. Contrasting effects of early diabetes and unilateral nephrectomy.
The Biochemical journal.
1986 Oct; 239(1):241-4. doi:
10.1042/bj2390241. [PMID: 2432888] - S Kunjara, M Sochor, A Adeoya, P McLean, A L Greenbaum. Concentration of phosphoribosyl pyrophosphate in the kidney during development and in experimental diabetic hypertrophy.
The Biochemical journal.
1986 Mar; 234(3):579-85. doi:
10.1042/bj2340579. [PMID: 2424432] - A C Foster, R Schwarcz. Characterization of quinolinic acid phosphoribosyltransferase in human blood and observations in Huntington's disease.
Journal of neurochemistry.
1985 Jul; 45(1):199-205. doi:
10.1111/j.1471-4159.1985.tb05493.x. [PMID: 2582090] - A H Chalmers, T Rotstein, M Mohan Rao, V R Marshall, M Coleman. Studies on the mechanism of immunosuppression with adenine.
International journal of immunopharmacology.
1985; 7(4):433-42. doi:
10.1016/0192-0561(85)90061-x. [PMID: 2412971] - D E Wisner, P A Simkin. Management of gout and hyperuricemia.
Primary care.
1984 Jun; 11(2):283-94. doi:
10.1016/s0095-4543(21)01190-8. [PMID: 6206519] - M A Becker, P Dicker, E Rozengurt. Mitogenic enhancement of purine base phosphoribosylation in Swiss mouse 3T3 cells.
The American journal of physiology.
1983 Mar; 244(3):C288-96. doi:
10.1152/ajpcell.1983.244.3.c288. [PMID: 6187219] - Y Nishida, I Akaoka, E Hayashi, T Miyamoto. Elevated erythrocyte phosphoribosylpyrophosphate and ATP concentrations in Japanese sumo wrestlers.
The British journal of nutrition.
1983 Jan; 49(1):3-7. doi:
10.1079/bjn19830004. [PMID: 6185138] - P Cortes, F Dumler, K K Venkatachalam, N W Levin. Effect of diabetes mellitus on renal metabolism.
Mineral and electrolyte metabolism.
1983; 9(4-6):306-16. doi:
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Cancer research.
1982 May; 42(5):2081-6. doi:
NULL. [PMID: 6175406] - A M Glasgow. A new method for measuring urinary orotic acid.
American journal of clinical pathology.
1982 Apr; 77(4):452-5. doi:
10.1093/ajcp/77.4.452. [PMID: 6176117] - M A Becker, M J Losman, P Itkin, P A Simkin. Gout with superactive phosphoribosylpyrophosphate synthetase due to increased enzyme catalytic rate.
The Journal of laboratory and clinical medicine.
1982 Apr; 99(4):495-511. doi:
NULL. [PMID: 6174658] - J M Buchanan, M L Smith, R J Smith. Regulation of nucleotide and pentose synthesis in resting and stimulated 3T6 fibroblasts.
Advances in enzyme regulation.
1982; 20(?):135-52. doi:
10.1016/0065-2571(82)90013-9. [PMID: 6180605] - A Leyva, H Nederbragt, J Lankelma, H M Pinedo. Methotrexate cytotoxicity: studies on its reversal by folates and nucleosides.
Cancer treatment reports.
1981; 65 Suppl 1(?):45-50. doi:
NULL. [PMID: 6173122] - P Cortes, C P Verghese, K K Venkatachalam, A M Schoenberger, N W Levin. Phosphoribosylpyrophosphate bioavailability in diabetic rat renal cortex in vivo.
The American journal of physiology.
1980 Apr; 238(4):E341-8. doi:
10.1152/ajpendo.1980.238.4.e341. [PMID: 6155074] - H G Zimmer. Restitution of myocardial adenine nucleotides: acceleration by administration of ribose.
Journal de physiologie.
1980; 76(7):769-75. doi:
NULL. [PMID: 6163849] - N Prajda, H P Morris, G Weber. Glutamine-phosphoribosylpyrophosphate amidotransferase (amidophosphoribosyltransferase, EC 2.4.2.14) activity in normal, differentiating, and neoplastic kidney.
Cancer research.
1979 Oct; 39(10):3909-14. doi:
NULL. [PMID: 476627] - R B Gordon, L Thompson, L A Johnson, B T Emmerson. Regulation of purine de novo synthesis in cultured human fibroblasts: the role of P-ribose-PP.
Biochimica et biophysica acta.
1979 Mar; 562(1):162-76. doi:
10.1016/0005-2787(79)90135-7. [PMID: 435498] - O Sperling, S Brosh, P Boer, B Kupfer, B Benjamin, A Weinberger, J Pinkhas. De novo synthesis of purine nucleotides and metabolic availability of phosphoribosylpyrophosphate in leukemic leukocytes.
Biomedicine / [publiee pour l'A.A.I.C.I.G.].
1979 Feb; 31(1):20-3. doi:
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Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952).
1979; 79(10):1379-85. doi:
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Clinica chimica acta; international journal of clinical chemistry.
1978 Dec; 90(3):217-23. doi:
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Pflugers Archiv : European journal of physiology.
1978 Sep; 376(3):223-7. doi:
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1978 Mar; 54(5):420-4. doi:
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1978; ?(35):65-79. doi:
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Journal of cellular physiology.
1977 Aug; 92(2):275-83. doi:
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In vitro.
1977 Jul; 13(7):429-33. doi:
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Annals of the rheumatic diseases.
1977 Jun; 36(3):261-3. doi:
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1977; 76A(?):270-9. doi:
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The New England journal of medicine.
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The Journal of clinical investigation.
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1974 Oct; 1(7):548-50. doi:
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. [PMID: 4620886]
