Phosphoribosyl pyrophosphate (BioDeep_00000001269)

 

Secondary id: BioDeep_00000415791

human metabolite Endogenous blood metabolite


代谢物信息卡片


[({[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl]oxy}(hydroxy)phosphoryl)oxy]phosphonic acid

化学式: C5H13O14P3 (389.9518)
中文名称: 磷酸核糖焦磷酸
谱图信息: 最多检出来源 Homo sapiens(blood) 32.68%

分子结构信息

SMILES: C(C1C(C(C(O1)OP(=O)(O)OP(=O)(O)O)O)O)OP(=O)(O)O
InChI: InChI=1S/C5H13O14P3/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13)/t2-,3-,4-,5+/m1/s1

描述信息

Phosphoribosyl pyrophosphate, also known as PRPP or PRib-PP, belongs to the class of organic compounds known as pentose phosphates. These are carbohydrate derivatives containing a pentose substituted by one or more phosphate groups. Phosphoribosyl pyrophosphate is an extremely weak basic (essentially neutral) compound (based on its pKa). Phosphoribosyl pyrophosphate exists in all living species, ranging from bacteria to humans. Within humans, phosphoribosyl pyrophosphate participates in a number of enzymatic reactions. In particular, guanine and phosphoribosyl pyrophosphate can be biosynthesized from guanosine monophosphate through its interaction with the enzyme adenine phosphoribosyltransferase. In addition, guanine and phosphoribosyl pyrophosphate can be biosynthesized from guanosine monophosphate; which is catalyzed by the enzyme hypoxanthine-guanine phosphoribosyltransferase. In humans, phosphoribosyl pyrophosphate is involved in adenosine deaminase deficiency. Phosphoribosyl pyrophosphate is a pentosephosphate and it is the key substance in the biosynthesis of histidine, tryptophan, and purine and pyrimidine nucleotides. It is formed from ribose 5-phosphate by the enzyme ribose-phosphate diphosphokinase. It plays a role in transferring phosphate groups in several reactions.
Phosphoribosyl pyrophosphate (PRPP) is a pentosephosphate. The key substance in the biosynthesis of histidine, tryptophan, and purine and pyrimidine nucleotides.
COVID info from COVID-19 Disease Map
KEIO_ID P023
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS

同义名列表

63 个代谢物同义名

[({[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl]oxy}(hydroxy)phosphoryl)oxy]phosphonic acid; alpha-D-Ribofuranose 5-(dihydrogen phosphoric acid) 1-(trihydrogen diphosphoric acid); a-D-Ribofuranose 5-(dihydrogen phosphoric acid) 1-(trihydrogen diphosphoric acid); Α-D-ribofuranose 5-(dihydrogen phosphoric acid) 1-(trihydrogen diphosphoric acid); alpha-D-5-(Dihydrogen phosphate) 1-(trihydrogen pyrophosphate) ribofuranose; alpha-D-Ribofuranose, 5-(dihydrogen phosphate) 1-(trihydrogen diphosphate); alpha-D-Ribofuranose 5-(dihydrogen phosphate) 1-(trihydrogen diphosphate); a-D-5-(Dihydrogen phosphate) 1-(trihydrogen pyrophosphate) ribofuranose; a-D-Ribofuranose, 5-(dihydrogen phosphate) 1-(trihydrogen diphosphate); Α-D-ribofuranose 5-(dihydrogen phosphate) 1-(trihydrogen diphosphate); a-D-Ribofuranose 5-(dihydrogen phosphate) 1-(trihydrogen diphosphate); alpha-D-Ribofuranose 5-phosphate 1-pyrophosphate; a-D-Ribofuranose 5-phosphate 1-pyrophosphate; 5-Phospho-alpha-D-ribose 1-diphosphoric acid; 5-Phospho-a-D-ribose 1-diphosphoric acid; alpha-D-5-Phosphoribosyl 1-pyrophosphate; 5-Phospho-α-D-ribose 1-diphosphoric acid; 5-Phospho-alpha-D-ribosyl pyrophosphate; ALPHA-PHOSPHORIBOSYLPYROphosphORIC ACID; 5-Phospho-alpha-D-ribose-1-diphosphate; 5-Phosphoribosyl 1-pyrophosphoric acid; 5-Phosphorylribose 1-alpha-diphosphate; 5-Phosphoribosyl alpha-1-pyrophosphate; 5-Phospho-alpha-D-ribose 1-diphosphate; a-D-5-Phosphoribosyl 1-pyrophosphate; Α-D-5-phosphoribosyl 1-pyrophosphate; a-PHOSPHORIBOSYLPYROphosphoric acid; 5-Phospho-a-D-ribosyl pyrophosphate; 5-Phosphorylribosyl 1-pyrophosphate; Α-phosphoribosylpyrophosphoric acid; 5-Phospho-α-D-ribosyl pyrophosphate; 5-Phosphoribosyl diphosphoric acid; 5-Phosphoribosyl a-1-pyrophosphate; 5-Phosphoribosyl α-1-pyrophosphate; 5-Phospho-a-D-ribose 1-diphosphate; 5-Phosphorylribose 1-a-diphosphate; 5-Phosphorylribose 1-α-diphosphate; 5-Phosphorylribose 1-pyrophosphate; 5-Phospho-α-D-ribose 1-diphosphate; Phosphoribosyl pyrophosphoric acid; 5-Phospho-α-D-ribose-1-diphosphate; 5-Phospho-a-D-ribose-1-diphosphate; alpha-PHOSPHORIBOSYLPYROphosphate; Phosphoribosylpyrophosphoric acid; 5-Phosphoribosyl 1-pyrophosphate; 5-Phospho-D-ribose 1-diphosphate; 5-Phosphoribosyl-1-pyrophosphate; 5-Phosphoribose 1-pyrophosphate; 5-Phosphoribosyl pyrophosphate; Phosphoribosyl-1-pyrophosphate; 5-phosphoribosyl-1-diphosphate; 5-Phosphoribosyl 1-diphosphate; a-PHOSPHORIBOSYLPYROphosphate; Phosphoribosylpyrophosphorate; Α-phosphoribosylpyrophosphate; Pyrophosphate, phosphoribosyl; Phosphoribosyl-pyrophosphate; 5-Phosphoribosyl diphosphate; Phosphoribosyl pyrophosphate; Phosphoribosylpyrophosphate; PP-Ribose-p; PRib-PP; PRPP



数据库引用编号

25 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(1)

BioCyc(13)

PlantCyc(0)

代谢反应

950 个相关的代谢反应过程信息。

Reactome(43)

BioCyc(37)

WikiPathways(3)

Plant Reactome(714)

INOH(14)

PlantCyc(0)

COVID-19 Disease Map(1)

PathBank(137)

PharmGKB(1)

4 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 13 ADA, APRT, EMP2, G6PD, NAMPT, PKM, PNP, PRPS1, PRPS2, PRPSAP1, PURA, QPRT, XDH
Peripheral membrane protein 2 ADA, G6PD
Endoplasmic reticulum membrane 1 TKT
Nucleus 6 ADK, EMP2, NAMPT, OMP, PKM, PURA
cytosol 15 ADA, ADK, APRT, G6PD, GLS, NAMPT, OMP, PKM, PNP, PPAT, PRPS1, PRPS2, QPRT, TKT, XDH
dendrite 1 PURA
nuclear body 1 TKT
nucleoplasm 3 ADK, APRT, TKT
Cell membrane 3 ADA, EMP2, TKT
Multi-pass membrane protein 1 EMP2
Golgi apparatus membrane 1 EMP2
Synapse 2 GLS, OMP
cell junction 2 ADA, NAMPT
cell surface 2 ADA, EMP2
glutamatergic synapse 1 PURA
Golgi apparatus 1 EMP2
Golgi membrane 2 EMP2, INS
neuronal cell body 2 OMP, PURA
postsynapse 1 PURA
Cytoplasm, cytosol 2 G6PD, GLS
Lysosome 1 ADA
plasma membrane 5 ADA, ADK, EMP2, GCG, TKT
Membrane 4 ADA, EMP2, G6PD, PRPS1
apical plasma membrane 2 EMP2, TKT
axon 1 OMP
extracellular exosome 7 APRT, G6PD, NAMPT, PKM, PNP, QPRT, TKT
extracellular space 5 GCG, INS, NAMPT, PNP, XDH
perinuclear region of cytoplasm 1 EMP2
mitochondrion 2 GLS, PKM
intracellular membrane-bounded organelle 1 G6PD
Single-pass type I membrane protein 1 TKT
Secreted 4 GCG, INS, NAMPT, PNP
extracellular region 5 APRT, GCG, INS, PKM, PNP
cytoplasmic side of plasma membrane 1 G6PD
mitochondrial matrix 1 GLS
Extracellular side 1 ADA
Cytoplasmic vesicle lumen 1 ADA
anchoring junction 1 ADA
centriolar satellite 1 G6PD
external side of plasma membrane 1 ADA
Extracellular vesicle 1 PKM
actin cytoskeleton 1 TKT
cytoplasmic vesicle 1 EMP2
apical part of cell 1 EMP2
vesicle 2 PKM, TKT
Apical cell membrane 1 EMP2
Cytoplasm, perinuclear region 1 EMP2
Membrane raft 1 EMP2
focal adhesion 1 TKT
Peroxisome 2 TKT, XDH
sarcoplasmic reticulum 1 XDH
collagen-containing extracellular matrix 1 PKM
nuclear speck 1 NAMPT
receptor complex 1 TKT
cilium 1 PKM
[Isoform 1]: Mitochondrion 1 GLS
chromosome, telomeric region 1 PURA
endosome lumen 1 INS
ficolin-1-rich granule lumen 2 PKM, PNP
secretory granule lumen 5 APRT, GCG, INS, PKM, PNP
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 GCG, INS
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
[Isoform 2]: Cytoplasm 1 ADK
[Isoform 1]: Nucleus 1 ADK
Rough endoplasmic reticulum 1 PKM
ribose phosphate diphosphokinase complex 3 PRPS1, PRPS2, PRPSAP1
[Isoform 3]: Mitochondrion 1 GLS
[Glutaminase kidney isoform, mitochondrial 68 kDa chain]: Mitochondrion matrix 1 GLS
[Glutaminase kidney isoform, mitochondrial 65 kDa chain]: Mitochondrion matrix 1 GLS
[Glucagon-like peptide 1]: Secreted 1 GCG
catalytic complex 1 QPRT
[Isoform M2]: Cytoplasm 1 PKM
[Isoform M1]: Cytoplasm 1 PKM


文献列表

  • Eziuche A Ugbogu, Lilian M Schweizer, Michael Schweizer. Contribution of Model Organisms to Investigating the Far-Reaching Consequences of PRPP Metabolism on Human Health and Well-Being. Cells. 2022 06; 11(12):. doi: 10.3390/cells11121909. [PMID: 35741038]
  • Qianqian Tian, Wanbo Li, Jiacheng Li, Yao Xiao, Baolan Wu, Zhiyong Wang, Fang Han. Towards Understanding PRPS1 as a Molecular Player in Immune Response in Yellow Drum (Nibea albiflora). International journal of molecular sciences. 2022 Jun; 23(12):. doi: 10.3390/ijms23126475. [PMID: 35742917]
  • Piero L Ipata, Marcella Camici, Vanna Micheli, Maria G Tozz. Metabolic network of nucleosides in the brain. Current topics in medicinal chemistry. 2011; 11(8):909-22. doi: 10.2174/156802611795347555. [PMID: 21401502]
  • Beata A Wolucka. Biosynthesis of D-arabinose in mycobacteria - a novel bacterial pathway with implications for antimycobacterial therapy. The FEBS journal. 2008 Jun; 275(11):2691-711. doi: 10.1111/j.1742-4658.2008.06395.x. [PMID: 18422659]
  • Hairong Huang, Stefan Berg, John S Spencer, Danny Vereecke, Wim D'Haeze, Marcelle Holsters, Michael R McNeil. Identification of amino acids and domains required for catalytic activity of DPPR synthase, a cell wall biosynthetic enzyme of Mycobacterium tuberculosis. Microbiology (Reading, England). 2008 Mar; 154(Pt 3):736-743. doi: 10.1099/mic.0.2007/013532-0. [PMID: 18310020]
  • Hairong Huang, Michael S Scherman, Wim D'Haeze, Danny Vereecke, Marcelle Holsters, Dean C Crick, Michael R McNeil. Identification and active expression of the Mycobacterium tuberculosis gene encoding 5-phospho-{alpha}-d-ribose-1-diphosphate: decaprenyl-phosphate 5-phosphoribosyltransferase, the first enzyme committed to decaprenylphosphoryl-d-arabinose synthesis. The Journal of biological chemistry. 2005 Jul; 280(26):24539-43. doi: 10.1074/jbc.m504068200. [PMID: 15878857]
  • Frederic D Sigoillot, David R Evans, Hedeel I Guy. Growth-dependent regulation of mammalian pyrimidine biosynthesis by the protein kinase A and MAPK signaling cascades. The Journal of biological chemistry. 2002 May; 277(18):15745-51. doi: 10.1074/jbc.m201112200. [PMID: 11872754]
  • Roger Schneiter, Andrew T Carter, Yolanda Hernando, Günther Zellnig, Lilian M Schweizer, Michael Schweizer. The importance of the five phosphoribosyl-pyrophosphate synthetase (Prs) gene products of Saccharomyces cerevisiae in the maintenance of cell integrity and the subcellular localization of Prs1p. Microbiology (Reading, England). 2000 Dec; 146 Pt 12(?):3269-3278. doi: 10.1099/00221287-146-12-3269. [PMID: 11101685]
  • E Zoref-Shani, S Feinstein, Y Frishberg, Y Bromberg, O Sperling. Kelley-Seegmiller syndrome due to a unique variant of hypoxanthine-guanine phosphoribosyltransferase: reduced affinity for 5-phosphoribosyl-1-pyrophosphate manifested only at low, physiological substrate concentrations. Biochimica et biophysica acta. 2000 Feb; 1500(2):197-203. doi: 10.1016/s0925-4439(99)00103-9. [PMID: 10657589]
  • R Curto, E O Voit, A Sorribas, M Cascante. Validation and steady-state analysis of a power-law model of purine metabolism in man. The Biochemical journal. 1997 Jun; 324 ( Pt 3)(?):761-75. doi: 10.1042/bj3240761. [PMID: 9210399]
  • C C Whitehead, H A McCormack, J S Rennie, M Frigg. Folic acid requirements of broilers. British poultry science. 1995 Mar; 36(1):113-21. doi: 10.1080/00071669508417757. [PMID: 7542146]
  • C T Tan, N Wollner, T Trippett, E Goker, W P Tong, A Kheradpour, P A Meyers, K M VanSyckle, L Guarino, Y Elisseyeff. Pharmacologic-guided trial of sequential methotrexate and thioguanine in children with advanced malignancies. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 1994 Sep; 12(9):1955-62. doi: 10.1200/jco.1994.12.9.1955. [PMID: 7521908]
  • N Z Baquer, M Sochor, S Kunjara, P McLean. Effect of oestradiol on the carbohydrate metabolism of immature rat uterus: the role of fructose-2, 6-bis-phosphate and of phosphoribosyl pyrophosphate. Biochemistry and molecular biology international. 1993 Nov; 31(3):509-19. doi: ". [PMID: 7509681]
  • S Hirai, Y Hayashi, T Koizumi, N Nakanishi, T Fukui, A Ichikawa. Fibroblast growth factor-dependent metabolism of hypoxanthine via the salvage pathway for purine synthesis in porcine aortic endothelial cells. Biochemical pharmacology. 1993 Apr; 45(8):1695-701. doi: 10.1016/0006-2952(93)90311-j. [PMID: 7683470]
  • S Kunjara, M Sochor, S Ahmed, A L Greenbaum, P McLean. Phosphoribosyl pyrophosphate formation in the rat adrenal gland in relation to adrenal growth in experimental diabetes. Diabetes. 1992 Nov; 41(11):1429-35. doi: 10.2337/diab.41.11.1429. [PMID: 1383069]
  • S Kunjara, M Sochor, M Ali, A Drake, A L Greenbaum, P McLean. Pyrimidine nucleotide synthesis in the rat kidney in early diabetes. Biochemical medicine and metabolic biology. 1991 Oct; 46(2):215-25. doi: 10.1016/0885-4505(91)90069-w. [PMID: 1723607]
  • M B van Der Weyden, I S Rose, P Newitt. Folate-deficient human lymphoblasts: changes in de novo purine and pyrimidine synthesis and phosphoribosylpyrophosphate. European journal of haematology. 1991 Sep; 47(3):213-8. doi: 10.1111/j.1600-0609.1991.tb01557.x. [PMID: 1717312]
  • E Harley, D Black, P Cole, T Marinaki, R Hickman. Applications of PRPP metabolism in human erythrocytes. Advances in experimental medicine and biology. 1991; 309B(?):341-3. doi: 10.1007/978-1-4615-7703-4_76. [PMID: 1723571]
  • J R Colofiore, R C Sawyer, M E Balis, D S Martin. Effect of uridine diphosphoglucose on levels of 5-phosphoribosyl pyrophosphate and uridine triphosphate in murine tissues. Pharmaceutical research. 1989 Oct; 6(10):863-6. doi: 10.1023/a:1015908505351. [PMID: 2481854]
  • M Sochor, S Kunjara, A L Greenbaum, P McLean. Changes in pathways of pentose phosphate formation in relation to phosphoribosyl pyrophosphate synthesis in the developing rat kidney. Effects of glucose concentration and electron acceptors. Journal of developmental physiology. 1989 Sep; 12(3):135-43. doi: . [PMID: 2483165]
  • S Lortet, H G Zimmer. Functional and metabolic effects of ribose in combination with prazosin, verapamil and metoprolol in rats in vivo. Cardiovascular research. 1989 Aug; 23(8):702-8. doi: 10.1093/cvr/23.8.702. [PMID: 2480849]
  • M Tatibana, S Ishijima, K Kita, T Ishizuka, N Suzuki. Early mitogenic stimulation of metabolic flux through phosphoribosyl pyrophosphate into nucleotides in Swiss 3T3 cells and requirement of external magnesium for the response. Advances in enzyme regulation. 1989; 28(?):147-66. doi: 10.1016/0065-2571(89)90069-1. [PMID: 2483026]
  • Y M Choy, W P Lam, K P Fung. Intracellular phosphoribosyl diphosphate level and glucose carrier in Ehrlich ascites tumour cells during tumour growth and diabetes in tumour-bearing mice. Cancer letters. 1988 Sep; 42(1-2):43-8. doi: 10.1016/0304-3835(88)90237-6. [PMID: 2460217]
  • K A Steer, M Sochor, S Kunjara, W Doepfner, P McLean. The effect of a somatostatin analogue (SMS 201-995, Sandostatin) on the concentration of phosphoribosyl pyrophosphate and the activity of the pentose phosphate pathway in the early renal hypertrophy of experimental diabetes in the rat. Biochemical medicine and metabolic biology. 1988 Apr; 39(2):226-33. doi: 10.1016/0885-4505(88)90080-1. [PMID: 2454125]
  • M A Kane, E Roth, G Raptis, C Schreiber, S Waxman. Effect of intracellular folate concentration on the modulation of 5-fluorouracil cytotoxicity by the elevation of phosphoribosylpyrophosphate in cultured human KB cells. Cancer research. 1987 Dec; 47(24 Pt 1):6444-50. doi: . [PMID: 2445472]
  • K K Arora, J F Williams. Introduction and metabolism of pentose and hexose phosphates in permeabilized Morris hepatoma 5123TC cells. Cell biochemistry and function. 1987 Oct; 5(4):289-300. doi: 10.1002/cbf.290050408. [PMID: 2445500]
  • J Ghitis, C Schreiber, S Waxman. Phosphate-induced phosphoribosylpyrophosphate elevations to assess deranged folate and purine nucleotide metabolism. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 1987 Oct; 186(1):90-5. doi: 10.3181/00379727-186-42590. [PMID: 2442765]
  • K K Harden, J L Robinson. Deficiency of UMP synthase in dairy cattle: a model for hereditary orotic aciduria. Journal of inherited metabolic disease. 1987; 10(3):201-9. doi: 10.1007/bf01800062. [PMID: 2448544]
  • S Kunjara, M Sochor, A L Greenbaum, P McLean. Concentration of phosphoribosyl pyrophosphate in renal hypertrophy. Contrasting effects of early diabetes and unilateral nephrectomy. The Biochemical journal. 1986 Oct; 239(1):241-4. doi: 10.1042/bj2390241. [PMID: 2432888]
  • S Kunjara, M Sochor, A Adeoya, P McLean, A L Greenbaum. Concentration of phosphoribosyl pyrophosphate in the kidney during development and in experimental diabetic hypertrophy. The Biochemical journal. 1986 Mar; 234(3):579-85. doi: 10.1042/bj2340579. [PMID: 2424432]
  • A C Foster, R Schwarcz. Characterization of quinolinic acid phosphoribosyltransferase in human blood and observations in Huntington's disease. Journal of neurochemistry. 1985 Jul; 45(1):199-205. doi: 10.1111/j.1471-4159.1985.tb05493.x. [PMID: 2582090]
  • A H Chalmers, T Rotstein, M Mohan Rao, V R Marshall, M Coleman. Studies on the mechanism of immunosuppression with adenine. International journal of immunopharmacology. 1985; 7(4):433-42. doi: 10.1016/0192-0561(85)90061-x. [PMID: 2412971]
  • D E Wisner, P A Simkin. Management of gout and hyperuricemia. Primary care. 1984 Jun; 11(2):283-94. doi: 10.1016/s0095-4543(21)01190-8. [PMID: 6206519]
  • M A Becker, P Dicker, E Rozengurt. Mitogenic enhancement of purine base phosphoribosylation in Swiss mouse 3T3 cells. The American journal of physiology. 1983 Mar; 244(3):C288-96. doi: 10.1152/ajpcell.1983.244.3.c288. [PMID: 6187219]
  • Y Nishida, I Akaoka, E Hayashi, T Miyamoto. Elevated erythrocyte phosphoribosylpyrophosphate and ATP concentrations in Japanese sumo wrestlers. The British journal of nutrition. 1983 Jan; 49(1):3-7. doi: 10.1079/bjn19830004. [PMID: 6185138]
  • P Cortes, F Dumler, K K Venkatachalam, N W Levin. Effect of diabetes mellitus on renal metabolism. Mineral and electrolyte metabolism. 1983; 9(4-6):306-16. doi: NULL. [PMID: 6197619]
  • C Benz, T Tillis, E Tattelman, E Cadman. Optimal schedule of methotrexate and 5-fluorouracil in human breast cancer. Cancer research. 1982 May; 42(5):2081-6. doi: NULL. [PMID: 6175406]
  • A M Glasgow. A new method for measuring urinary orotic acid. American journal of clinical pathology. 1982 Apr; 77(4):452-5. doi: 10.1093/ajcp/77.4.452. [PMID: 6176117]
  • M A Becker, M J Losman, P Itkin, P A Simkin. Gout with superactive phosphoribosylpyrophosphate synthetase due to increased enzyme catalytic rate. The Journal of laboratory and clinical medicine. 1982 Apr; 99(4):495-511. doi: NULL. [PMID: 6174658]
  • J M Buchanan, M L Smith, R J Smith. Regulation of nucleotide and pentose synthesis in resting and stimulated 3T6 fibroblasts. Advances in enzyme regulation. 1982; 20(?):135-52. doi: 10.1016/0065-2571(82)90013-9. [PMID: 6180605]
  • A Leyva, H Nederbragt, J Lankelma, H M Pinedo. Methotrexate cytotoxicity: studies on its reversal by folates and nucleosides. Cancer treatment reports. 1981; 65 Suppl 1(?):45-50. doi: NULL. [PMID: 6173122]
  • P Cortes, C P Verghese, K K Venkatachalam, A M Schoenberger, N W Levin. Phosphoribosylpyrophosphate bioavailability in diabetic rat renal cortex in vivo. The American journal of physiology. 1980 Apr; 238(4):E341-8. doi: 10.1152/ajpendo.1980.238.4.e341. [PMID: 6155074]
  • H G Zimmer. Restitution of myocardial adenine nucleotides: acceleration by administration of ribose. Journal de physiologie. 1980; 76(7):769-75. doi: NULL. [PMID: 6163849]
  • N Prajda, H P Morris, G Weber. Glutamine-phosphoribosylpyrophosphate amidotransferase (amidophosphoribosyltransferase, EC 2.4.2.14) activity in normal, differentiating, and neoplastic kidney. Cancer research. 1979 Oct; 39(10):3909-14. doi: NULL. [PMID: 476627]
  • R B Gordon, L Thompson, L A Johnson, B T Emmerson. Regulation of purine de novo synthesis in cultured human fibroblasts: the role of P-ribose-PP. Biochimica et biophysica acta. 1979 Mar; 562(1):162-76. doi: 10.1016/0005-2787(79)90135-7. [PMID: 435498]
  • O Sperling, S Brosh, P Boer, B Kupfer, B Benjamin, A Weinberger, J Pinkhas. De novo synthesis of purine nucleotides and metabolic availability of phosphoribosylpyrophosphate in leukemic leukocytes. Biomedicine / [publiee pour l'A.A.I.C.I.G.]. 1979 Feb; 31(1):20-3. doi: . [PMID: 289423]
  • A M Shaposhnikov, L A Aleksandrova. [Clinical and biochemical heterogeneity of the Lesch-Nyhan syndrome]. Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952). 1979; 79(10):1379-85. doi: NULL. [PMID: 227197]
  • W J Tax, J H Veerkamp, E D Schretlen. The urinary excretion of orotic acid and orotidine, measured by an isotope dilution assay. Clinica chimica acta; international journal of clinical chemistry. 1978 Dec; 90(3):217-23. doi: 10.1016/0009-8981(78)90260-7. [PMID: 365397]
  • H G Zimmer, E Gerlach. Stimulation of myocardial adenine nucleotide biosynthesis by pentoses and pentitols. Pflugers Archiv : European journal of physiology. 1978 Sep; 376(3):223-7. doi: 10.1007/bf00584954. [PMID: 568251]
  • M Pizzichini, V Micheli, R Marcolongo, E Marinello. [Ribose metabolism in man]. Bollettino della Societa italiana di biologia sperimentale. 1978 Mar; 54(5):420-4. doi: NULL. [PMID: 737070]
  • D Paul, H J Ristow, H T Rupniak, T O Messmer. Growth control by serum factors and hormones in mammalian cells in culture. The ... Symposium. Society for Developmental Biology. Symposium. 1978; ?(35):65-79. doi: 10.1016/b978-0-12-612981-6.50009-0. [PMID: 205968]
  • S D Skaper, E B Spector, J E Seegmiller. Reversion in expression of hypoxanthine-guanine phosphoribosyltransferase in 6-thioguanine resistant neuroblastoma: evidence for reduced enzyme levels associated with unaltered catalytic activity. Journal of cellular physiology. 1977 Aug; 92(2):275-83. doi: 10.1002/jcp.1040920216. [PMID: 18484]
  • C W Long, R DelGiudice, R S Gardella, M Hatanaka. Uracil phosphoribosyl transferase activity of mycoplasma and infected cell cultures. In vitro. 1977 Jul; 13(7):429-33. doi: 10.1007/bf02615103. [PMID: 560353]
  • Y Nishida, I Akaoka, T Nishizawa, M Maruki, K Maruki. Synthesis and concentration of 5-phosphoribosyl-1-pyrophosphate in erythrocytes from patients with Down's syndrome. Annals of the rheumatic diseases. 1977 Jun; 36(3):261-3. doi: 10.1136/ard.36.3.261. [PMID: 141914]
  • L H Siegenbeek Van Heukelom, J W Akkerman, G E Staal, C H De Bruyn, J W Stoop, B J Zegers, P K De Bree, S K Wadman. A patient with purine nucleoside phosphorylase deficiency: enzymological and metabolic aspects. Clinica chimica acta; international journal of clinical chemistry. 1977 Feb; 74(3):271-9. doi: 10.1016/0009-8981(77)90294-7. [PMID: 401697]
  • T Hovi, A C Allison, K Raivio, A Vaheri. Purine metabolism and control of cell proliferation. Ciba Foundation symposium. 1977; ?(48):225-48. doi: 10.1002/9780470720301.ch14. [PMID: 204461]
  • M A Becker. Fibroblast phosphoribosylpyrophosphate and ribose-5-phosphate concentration and generation in gout with purine overproduction. Advances in experimental medicine and biology. 1977; 76A(?):270-9. doi: 10.1007/978-1-4613-4223-6_33. [PMID: 193370]
  • R Marcolongo, G Pompucci, V Micheli. Familial distribution of increased erythrocyte PP-ribose-P levels. Advances in experimental medicine and biology. 1977; 76A(?):280-6. doi: 10.1007/978-1-4613-4223-6_34. [PMID: 193371]
  • A Cohen, D Doyle, D W Martin, A J Ammann. Abnormal purine metabolism and purine overproduction in a patient deficient in purine nucleoside phosphorylase. The New England journal of medicine. 1976 Dec; 295(26):1449-54. doi: 10.1056/nejm197612232952603. [PMID: 825775]
  • P Badenoch-Jones, P J Buttery. The effects of added purines on urate and purine synthesis de novo by isolated chick liver, kidney and lymphoid cells. The Biochemical journal. 1976 Sep; 158(3):549-56. doi: 10.1042/bj1580549. [PMID: 985448]
  • D Stormont, C Davies, B T Emmerson. Urate production in heterozygotes for glucose-6-phosphatase deficiency. Clinica chimica acta; international journal of clinical chemistry. 1976 Sep; 71(2):303-8. doi: 10.1016/0009-8981(76)90544-1. [PMID: 183920]
  • M E Balis. Uric acid metabolism in man. Advances in clinical chemistry. 1976; 18(?):213-46. doi: 10.1016/s0065-2423(08)60299-1. [PMID: 176879]
  • E Zoref, A De Vries, O Sperling. Mutant feedback-resistant phosphoribosylpyrophosphate synthetase associated with purine overproduction and gout. Phosphoribosylpyrophosphate and purine metabolism in cultured fibroblasts. The Journal of clinical investigation. 1975 Nov; 56(5):1093-9. doi: 10.1172/jci108183. [PMID: 171280]
  • D P Mertz. [Theory of pathogenesis in primary hyperuricamia]. Medizinische Klinik. 1975 Jul; 70(28-29):1187-98. doi: NULL. [PMID: 170496]
  • L B Sorensen, D J Levinson. Origin and extrarenal elimination of uric acid in man. Nephron. 1975; 14(1):7-20. doi: 10.1159/000180432. [PMID: 1124137]
  • W Kaiser, K Stocker, P U Heuckenkamp. [Mechanism of serum uric acid increase during continuous xylitol infusions]. Die Infusionstherapie. 1974 Oct; 1(7):548-50. doi: NULL. [PMID: 4219390]
  • W Kaiser, K Stocker, P U Heuckenkamp. [Studies of the mechanism of serum uric acid elevation during continuous infusion of xylitol]. Die Infusionstherapie. 1974 Oct; 1(7):548-50. doi: NULL. [PMID: 4219391]
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