phenothrin (BioDeep_00000413016)

   


代谢物信息卡片


phenothrin

化学式: C23H26O3 (350.1882)
中文名称: 右旋苯醚菊酯, 苯醚菊酯
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=CC1C(C1(C)C)C(=O)OCC2=CC(=CC=C2)OC3=CC=CC=C3)C
InChI: InChI=1S/C23H26O3/c1-16(2)13-20-21(23(20,3)4)22(24)25-15-17-9-8-12-19(14-17)26-18-10-6-5-7-11-18/h5-14,20-21H,15H2,1-4H3

描述信息

P - Antiparasitic products, insecticides and repellents > P03 - Ectoparasiticides, incl. scabicides, insecticides and repellents > P03A - Ectoparasiticides, incl. scabicides > P03AC - Pyrethrines, incl. synthetic compounds
D010575 - Pesticides > D007306 - Insecticides > D011722 - Pyrethrins
D016573 - Agrochemicals
CONFIDENCE standard compound; INTERNAL_ID 672; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5809; ORIGINAL_PRECURSOR_SCAN_NO 5806
CONFIDENCE standard compound; INTERNAL_ID 672; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5831; ORIGINAL_PRECURSOR_SCAN_NO 5829
CONFIDENCE standard compound; INTERNAL_ID 672; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5837; ORIGINAL_PRECURSOR_SCAN_NO 5834
CONFIDENCE standard compound; INTERNAL_ID 672; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5839; ORIGINAL_PRECURSOR_SCAN_NO 5837
CONFIDENCE standard compound; INTERNAL_ID 672; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 10868; ORIGINAL_PRECURSOR_SCAN_NO 10863
CONFIDENCE standard compound; INTERNAL_ID 672; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 10984; ORIGINAL_PRECURSOR_SCAN_NO 10980

同义名列表

3 个代谢物同义名

phenothrin; Phenothrin; Sumithrin



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 CDR2, CTNNB1, HPGDS, NR1I3, TNKS, TNKS2
Peripheral membrane protein 3 ACHE, ERVW-1, TNKS
Nucleus 8 ACHE, CTNNB1, KDR, NR1I2, NR1I3, PPARA, TNKS, TNKS2
cytosol 5 CTNNB1, HPGDS, NR1I3, TNKS, TNKS2
nuclear body 2 NR1I2, TNKS
centrosome 1 CTNNB1
nucleoplasm 7 CTNNB1, HPGDS, NR1I2, NR1I3, PPARA, SCNN1G, TNKS
Cell membrane 4 ACHE, CTNNB1, GP2, KDR
lamellipodium 1 CTNNB1
Multi-pass membrane protein 1 SCNN1G
Golgi apparatus membrane 1 TNKS
Synapse 2 ACHE, CTNNB1
cell cortex 1 CTNNB1
cell junction 2 CTNNB1, KDR
cell surface 2 ACHE, GP2
glutamatergic synapse 1 CTNNB1
Golgi apparatus 3 ACHE, KDR, TNKS
Golgi membrane 2 TNKS, TNKS2
neuromuscular junction 1 ACHE
presynaptic membrane 1 CTNNB1
endosome 2 GP2, KDR
plasma membrane 7 ACHE, BCHE, CTNNB1, ERVW-1, GP2, KDR, SCNN1G
Membrane 2 ACHE, CTNNB1
apical plasma membrane 2 GP2, SCNN1G
basolateral plasma membrane 1 CTNNB1
extracellular exosome 3 CTNNB1, GP2, SCNN1G
endoplasmic reticulum 1 KDR
extracellular space 5 ACHE, BCHE, GP2, TG, WNT10B
perinuclear region of cytoplasm 3 ACHE, CTNNB1, TNKS2
Schaffer collateral - CA1 synapse 1 CTNNB1
adherens junction 1 CTNNB1
apicolateral plasma membrane 1 CTNNB1
bicellular tight junction 1 CTNNB1
protein-containing complex 1 CTNNB1
intracellular membrane-bounded organelle 1 HPGDS
Single-pass type I membrane protein 1 ERVW-1
Secreted 5 ACHE, BCHE, GP2, TG, WNT10B
extracellular region 6 ACHE, BCHE, GP2, KDR, TG, WNT10B
[Isoform 2]: Secreted 1 KDR
Extracellular side 1 ACHE
anchoring junction 1 KDR
transcription regulator complex 2 CTNNB1, NR1I2
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TNKS
nuclear membrane 1 TNKS
external side of plasma membrane 3 GP2, KDR, SCNN1G
Secreted, extracellular space, extracellular matrix 1 WNT10B
Z disc 1 CTNNB1
beta-catenin destruction complex 1 CTNNB1
Wnt signalosome 1 CTNNB1
Early endosome 1 KDR
apical part of cell 1 CTNNB1
cell-cell junction 1 CTNNB1
postsynaptic membrane 1 CTNNB1
Apical cell membrane 2 GP2, SCNN1G
Membrane raft 2 GP2, KDR
Cytoplasm, cytoskeleton 2 CTNNB1, NR1I3
focal adhesion 1 CTNNB1
Cell junction, adherens junction 1 CTNNB1
flotillin complex 1 CTNNB1
basement membrane 1 ACHE
fascia adherens 1 CTNNB1
lateral plasma membrane 1 CTNNB1
receptor complex 1 KDR
Zymogen granule membrane 1 GP2
chromatin 3 NR1I2, NR1I3, PPARA
cell periphery 1 CTNNB1
cytoskeleton 1 NR1I3
Cytoplasm, cytoskeleton, cilium basal body 1 CTNNB1
spindle pole 1 CTNNB1
Chromosome, telomere 2 TNKS, TNKS2
chromosome, telomeric region 2 TNKS, TNKS2
blood microparticle 1 BCHE
postsynaptic density, intracellular component 1 CTNNB1
Lipid-anchor, GPI-anchor 2 ACHE, GP2
microvillus membrane 1 CTNNB1
Cytoplasm, cytoskeleton, spindle pole 1 TNKS
Nucleus, nuclear pore complex 1 TNKS
nuclear envelope 1 TNKS2
nuclear pore 1 TNKS
Endomembrane system 1 CTNNB1
sorting endosome 1 KDR
sodium channel complex 1 SCNN1G
euchromatin 1 CTNNB1
side of membrane 1 ACHE
intermediate filament cytoskeleton 1 NR1I2
endoplasmic reticulum lumen 1 BCHE
mitotic spindle pole 1 TNKS
beta-catenin-TCF complex 1 CTNNB1
nuclear envelope lumen 1 BCHE
presynaptic active zone cytoplasmic component 1 CTNNB1
synaptic cleft 1 ACHE
protein-DNA complex 1 CTNNB1
[Transmembrane protein]: Cell membrane 1 ERVW-1
[Surface protein]: Cell membrane 1 ERVW-1
pericentriolar material 2 TNKS, TNKS2
catenin complex 1 CTNNB1
beta-catenin-TCF7L2 complex 1 CTNNB1
[Isoform H]: Cell membrane 1 ACHE
beta-catenin-ICAT complex 1 CTNNB1
Scrib-APC-beta-catenin complex 1 CTNNB1
[Syncytin-1]: Virion 1 ERVW-1


文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Cláudio E T Parente, Julliana Lestayo, Yago S Guida, Claudio E Azevedo-Silva, João Paulo M Torres, Rodrigo O Meire, Olaf Malm. Pyrethroids in chicken eggs from commercial farms and home production in Rio de Janeiro: Estimated daily intake and diastereomeric selectivity. Chemosphere. 2017 Oct; 184(?):1261-1269. doi: 10.1016/j.chemosphere.2017.06.109. [PMID: 28672725]
  • Enes Atmaca, Abdurrahman Aksoy. d-Phenothrin-induced oxidative DNA damage in rat liver and kidney determined by HPLC-ECD/DAD. Environmental toxicology. 2015 May; 30(5):607-13. doi: 10.1002/tox.21938. [PMID: 24339023]
  • Chia-Wen Hsu, Jinghua Zhao, Ruili Huang, Jui-Hua Hsieh, Jon Hamm, Xiaoqing Chang, Keith Houck, Menghang Xia. Quantitative high-throughput profiling of environmental chemicals and drugs that modulate farnesoid X receptor. Scientific reports. 2014 Sep; 4(?):6437. doi: 10.1038/srep06437. [PMID: 25257666]
  • Yoshie Hata, Stefanie Zimmermann, Melanie Quitschau, Marcel Kaiser, Matthias Hamburger, Michael Adams. Antiplasmodial and antitrypanosomal activity of pyrethrins and pyrethroids. Journal of agricultural and food chemistry. 2011 Sep; 59(17):9172-6. doi: 10.1021/jf201776z. [PMID: 21786822]
  • Chiu-Hwa Lin, Cheing-Tong Yan, Ponnusamy Vinoth Kumar, Hong-Ping Li, Jen-Fon Jen. Determination of pyrethroid metabolites in human urine using liquid phase microextraction coupled in-syringe derivatization followed by gas chromatography/electron capture detection. Analytical and bioanalytical chemistry. 2011 Aug; 401(3):927-37. doi: 10.1007/s00216-011-5122-0. [PMID: 21667061]
  • Marc Tebruegge, Anastasia Pantazidou, Nigel Curtis. What's bugging you? An update on the treatment of head lice infestation. Archives of disease in childhood. Education and practice edition. 2011 Feb; 96(1):2-8. doi: 10.1136/adc.2009.178038. [PMID: 20688849]
  • Peter B Key, Katy W Chung, Jennifer Hoguet, Yelena Sapozhnikova, Marie E Delorenzo. Toxicity of the mosquito control insecticide phenothrin to three life stages of the grass shrimp (Palaemonetes pugio). Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. 2011; 46(5):426-31. doi: 10.1080/03601234.2011.572519. [PMID: 21614717]
  • Miriam F Cooperband, Frances V Golden, Gary G Clark, William Jany, Sandra A Allan. Prallethrin-induced excitation increases contact between sprayed ultralow volume droplets and flying mosquitoes (Diptera: Culicidae) in a wind tunnel. Journal of medical entomology. 2010 Nov; 47(6):1099-106. doi: 10.1603/me10021. [PMID: 21175059]
  • Han-Young Choi, Young-Cheol Yang, Si Hyeock Lee, J Marshall Clark, Young-Joon Ahn. Efficacy of spray formulations containing binary mixtures of clove and eucalyptus oils against susceptible and pyrethroid/ malathion-resistant head lice (Anoplura: Pediculidae). Journal of medical entomology. 2010 May; 47(3):387-91. doi: 10.1603/me09119. [PMID: 20496586]
  • Edith Berger-Preiss, Wolfgang Koch, Susanne Gerling, Heiko Kock, Klaus E Appel. Use of biocidal products (insect sprays and electro-vaporizer) in indoor areas--exposure scenarios and exposure modeling. International journal of hygiene and environmental health. 2009 Sep; 212(5):505-18. doi: 10.1016/j.ijheh.2009.02.001. [PMID: 19345645]
  • A O J Amoo, Rui-De Xue, W A Qualls, B P Quinn, U R Bernier. Residual efficacy of field-applied permethrin, d-phenothrin, and resmethrin on plant foliage against adult mosquitoes. Journal of the American Mosquito Control Association. 2008 Dec; 24(4):543-9. doi: 10.2987/08-5783.1. [PMID: 19181063]
  • Gabriele Leng, Wolfgang Gries, Sami Selim. Biomarker of pyrethrum exposure. Toxicology letters. 2006 Apr; 162(2-3):195-201. doi: 10.1016/j.toxlet.2005.09.030. [PMID: 16257148]
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  • Tomoya Yamada, Shinji Ueda, Kaoru Yoshioka, Satoshi Kawamura, Takaki Seki, Yasuyoshi Okuno, Nobuyoshi Mikami. Lack of estrogenic or (anti-)androgenic effects of d-phenothrin in the uterotrophic and Hershberger assays. Toxicology. 2003 Apr; 186(3):227-39. doi: 10.1016/s0300-483x(02)00750-3. [PMID: 12628315]
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