D-Glucosamine (BioDeep_00000412599)
Main id: BioDeep_00000001863
PANOMIX_OTCML-2023 BioNovoGene_Lab2019
代谢物信息卡片
2-Amino-2-deoxyhexopyranose
化学式: C6H13NO5 (179.0794)
中文名称: 2-氨基-2-脱氧-D-吡喃葡萄糖, D-(+)-葡萄糖胺 盐酸盐, β-D-葡糖胺
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(C1C(C(C(C(O1)O)N)O)O)O
InChI: InChI=1S/C6H13NO5/c7-3-5(10)4(9)2(1-8)12-6(3)11/h2-6,8-11H,1,7H2/t2-,3-,4-,5-,6?/m1/s1
描述信息
M - Musculo-skeletal system > M01 - Antiinflammatory and antirheumatic products > M01A - Antiinflammatory and antirheumatic products, non-steroids
Glucosamine (D-Glucosamine) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes[1].
Glucosamine (D-Glucosamine) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes[1].
Glucosamine (D-Glucosamine) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes[1].
同义名列表
数据库引用编号
23 个数据库交叉引用编号
- ChEBI: CHEBI:47977
- ChEBI: CHEBI:17315
- ChEBI: CHEBI:5417
- KEGG: C00329
- KEGGdrug: D04334
- PubChem: 439213
- DrugBank: DB01296
- ChEMBL: CHEMBL493287
- MeSH: Glucosamine
- CAS: 90-77-7
- MoNA: MoNA016859
- MoNA: MoNA016687
- MoNA: MoNA016603
- MoNA: MoNA016588
- PubChem: 3623
- CAS: 3416-24-8
- PDB-CCD: GCS
- PDB-CCD: PA1
- 3DMET: B04670
- NIKKAJI: J10.582A
- medchemexpress: HY-B1125
- BioNovoGene_Lab2019: BioNovoGene_Lab2019-120
- KNApSAcK: 47977
分类词条
相关代谢途径
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
5 个相关的物种来源信息
- 3483 - Cannabis sativa: 10.1021/NP50008A001
- 6669 - Daphnia pulex: 10.1038/SREP25125
- 879918 - Juncus roemerianus: 10.18785/GRR.0602.07
- 157169 - Ramalina fraxinea: 10.5586/ASBP.1979.002
- 5691 - Trypanosoma brucei: 10.1371/JOURNAL.PNTD.0001618
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yuan Zhang, Line A Borch, Niklas H Fischer, Morten Meldal. Hydrodynamic Control of Alzheimer Aβ Fibrillation with Glucosaminic Acid Containing Click-Cyclized β-Bodies.
Journal of the American Chemical Society.
2024 Jan; 146(4):2654-2662. doi:
10.1021/jacs.3c12118. [PMID: 38126710] - Sang-Min Kim, Dong Yeol Kim, Jiwon Park, Young-Ah Moon, Inn-Oc Han. Glucosamine increases macrophage lipid accumulation by regulating the mammalian target of rapamycin signaling pathway.
BMB reports.
2023 Nov; ?(?):. doi:
. [PMID: 37964636] - Akshayaa Venkataraghavan, Julian G Schwerdt, Stephen D Tyerman, Maria Hrmova. Barley Nodulin 26-like Intrinsic Protein permeates water, metalloids, saccharides, and ion pairs due to structural plasticity and diversification.
The Journal of biological chemistry.
2023 Oct; ?(?):105410. doi:
10.1016/j.jbc.2023.105410. [PMID: 37913906] - Feng Li, Zhengyan Zhang, Yan Bai, Qishi Che, Hua Cao, Jiao Guo, Zhengquan Su. Glucosamine Improves Non-Alcoholic Fatty Liver Disease Induced by High-Fat and High-Sugar Diet through Regulating Intestinal Barrier Function, Liver Inflammation, and Lipid Metabolism.
Molecules (Basel, Switzerland).
2023 Oct; 28(19):. doi:
10.3390/molecules28196918. [PMID: 37836761] - Yihao Liu, Zhen Qin, Chunling Wang, Zhengqiang Jiang. N-acetyl-d-glucosamine-based oligosaccharides from chitin: Enzymatic production, characterization and biological activities.
Carbohydrate polymers.
2023 Sep; 315(?):121019. doi:
10.1016/j.carbpol.2023.121019. [PMID: 37230627] - Zeqi Li, Bo Fu, Aili Wei, Yanchen Wu, Ming Huang, Enhao Zhang, Bo Cui, Bo Wang, Hui Peng. d-Glucosamine induces circadian phase delay by promoting BMAL1 degradation through AMPK/mTOR pathway.
Life sciences.
2023 Jul; 325(?):121765. doi:
10.1016/j.lfs.2023.121765. [PMID: 37169147] - Giorgia Della Rocca, Carlo Schievano, Alessandra Di Salvo, Maria Beatrice Conti, Maria Federica Della Valle. Palmitoyl-glucosamine co-micronized with curcumin for maintenance of meloxicam-induced pain relief in dogs with osteoarthritis pain.
BMC veterinary research.
2023 Feb; 19(1):37. doi:
10.1186/s12917-023-03594-4. [PMID: 36747264] - Yingde Xu, Liangjie Sun, Xiaodan Gao, Jingkuan Wang. Contrasting response of fungal versus bacterial residue accumulation within soil aggregates to long-term fertilization.
Scientific reports.
2022 10; 12(1):17834. doi:
10.1038/s41598-022-22064-9. [PMID: 36284223] - G Zhou, M W Zhao, Y P Cao, J H Lin, W G Wang, A Guo, H Tian. [A multicenter cross-sectional study of quality of life and nonsurgical treatment in patients with knee osteoarthritis].
Zhonghua yi xue za zhi.
2022 Sep; 102(35):2799-2805. doi:
10.3760/cma.j.cn112137-20220406-00719. [PMID: 36124353] - Ying Chen, Xiaoming Liao, Pei Jing, Liangkui Hu, Zengqiu Yang, Yongchao Yao, Chunyan Liao, Shiyong Zhang. Linoleic Acid-Glucosamine Hybrid for Endogenous Iron-Activated Ferroptosis Therapy in High-Grade Serous Ovarian Cancer.
Molecular pharmaceutics.
2022 09; 19(9):3187-3198. doi:
10.1021/acs.molpharmaceut.2c00333. [PMID: 35939328] - Kun Gao, Yukun Qin, Linsong Wang, Xin Li, Song Liu, Ronge Xing, HuaHua Yu, Xiaolin Chen, Pengcheng Li. Design, Synthesis, and Antifungal Activities of Hymexazol Glycosides Based on a Biomimetic Strategy.
Journal of agricultural and food chemistry.
2022 Aug; 70(30):9520-9535. doi:
10.1021/acs.jafc.2c02507. [PMID: 35877994] - Jing Chen, Li-Na Huo, Yuan Gao, Yun-Li Zhang, Ye Chen. Two new N-acetyl-ᴅ-glucosamine derivatives from the medical algae-derived endophytic fungus Penicillium chrysogenum.
Natural product research.
2022 Aug; 36(15):3988-3991. doi:
10.1080/14786419.2021.1889543. [PMID: 33957817] - Venkanna Babu Mullapudi, Kendall C Craig, Zhongwu Guo. Design and Synthesis of a Doubly Functionalized Core Structure of a Glycosylphosphatidylinositol Anchor Containing Photoreactive and Clickable Functional Groups.
The Journal of organic chemistry.
2022 07; 87(14):9419-9425. doi:
10.1021/acs.joc.2c00901. [PMID: 35766889] - Bojian Chen, Lei Fang, Liangzhuo Lin, Yang Lv, Zexin Huang, Xiaodong Lin, Xin Wang. Aerobic exercise combined with glucosamine hydrochloride capsules inhibited the apoptosis of chondrocytes in rabbit knee osteoarthritis by affecting TRPV5 expression.
Gene.
2022 Jul; 830(?):146465. doi:
10.1016/j.gene.2022.146465. [PMID: 35427733] - Alexandre de Fátima Cobre, Monica Surek, Dile Pontarolo Stremel, Mariana Millan Fachi, Helena Hiemisch Lobo Borba, Fernanda Stumpf Tonin, Roberto Pontarolo. Diagnosis and prognosis of COVID-19 employing analysis of patients' plasma and serum via LC-MS and machine learning.
Computers in biology and medicine.
2022 Jul; 146(?):105659. doi:
10.1016/j.compbiomed.2022.105659. [PMID: 35751188] - Janeala J Morsby, Bradley D Smith. Advances in Optical Sensors of N-Acetyl-β-d-hexosaminidase (N-Acetyl-β-d-glucosaminidase).
Bioconjugate chemistry.
2022 04; 33(4):544-554. doi:
10.1021/acs.bioconjchem.2c00057. [PMID: 35302753] - Peipei Han, Yingying Wei, Shu Jiang, Yi Chen, Feng Xu, Hongfei Wang, Xingfeng Shao. N-Acetyl-d-glucosamine Inhibition of Hexokinase Results in Downregulation of the Phenylpropanoid Metabolic Pathway and Decreased Resistance to Brown Rot in Peach Fruit.
Journal of agricultural and food chemistry.
2022 Mar; 70(12):3917-3928. doi:
10.1021/acs.jafc.1c06573. [PMID: 35298175] - Salim Cerig, Fatime Geyikoglu. Oxidative stress and cyto-genotoxicity induced by poly-d-glucosamine in human blood cells in vitro.
Zeitschrift fur Naturforschung. C, Journal of biosciences.
2022 Jan; 77(1-2):43-55. doi:
10.1515/znc-2021-0080. [PMID: 34036758] - Rebecca A Bova, Angela Melton-Celsa. Shiga toxin (Stx) type 2-induced increase in O-linked N-acetyl glucosamine protein modification: a new therapeutic target?.
EMBO molecular medicine.
2022 01; 14(1):e15389. doi:
10.15252/emmm.202115389. [PMID: 34935281] - Sekhu Ansari, Dharmendra Nath Bhatt, Chandni Sood, Asis Datta. Functional characterization of the LdNAGD gene in Leishmania donovani.
Microbiological research.
2021 Oct; 251(?):126830. doi:
10.1016/j.micres.2021.126830. [PMID: 34385082] - Congcong Zhang, Yongjie Niu, Zhixian Wang, Xin Xu, Yan Li, Lifang Ma, Jiayi Wang, Yongchun Yu. Corosolic acid inhibits cancer progression by decreasing the level of CDK19-mediated O-GlcNAcylation in liver cancer cells.
Cell death & disease.
2021 09; 12(10):889. doi:
10.1038/s41419-021-04164-y. [PMID: 34588426] - Fabio A Facchini, Alberto Minotti, Andrea Luraghi, Alessio Romerio, Nicole Gotri, Alejandra Matamoros-Recio, Andrea Iannucci, Charys Palmer, Guanbo Wang, Rebecca Ingram, Sonsoles Martin-Santamaria, Grisha Pirianov, Marco De Andrea, Miguel A Valvano, Francesco Peri. Synthetic Glycolipids as Molecular Vaccine Adjuvants: Mechanism of Action in Human Cells and In Vivo Activity.
Journal of medicinal chemistry.
2021 08; 64(16):12261-12272. doi:
10.1021/acs.jmedchem.1c00896. [PMID: 34382796] - Seyedeh Fatemeh Mirpoor, Odile Francesca Restaino, Chiara Schiraldi, Concetta Valeria L Giosafatto, Francesco Ruffo, Raffaele Porta. Lignin/Carbohydrate Complex Isolated from Posidonia oceanica Sea Balls (Egagropili): Characterization and Antioxidant Reinforcement of Protein-Based Films.
International journal of molecular sciences.
2021 Aug; 22(17):. doi:
10.3390/ijms22179147. [PMID: 34502058] - Speranta Avram, Ana Maria Udrea, Diana Camelia Nuta, Carmen Limban, Adrian Cosmin Balea, Miron Teodor Caproiu, Florea Dumitrascu, Cătălin Buiu, Alexandra Teodora Bordei. Synthesis and Bioinformatic Characterization of New Schiff Bases with Possible Applicability in Brain Disorders.
Molecules (Basel, Switzerland).
2021 Jul; 26(14):. doi:
10.3390/molecules26144160. [PMID: 34299440] - Jessica M Moon, Peter Finnegan, Richard A Stecker, Hanna Lee, Kayla M Ratliff, Ralf Jäger, Martin Purpura, Carolyn M Slupsky, Maria L Marco, Craig J Wissent, Jason Theodosakis, Chad M Kerksick. Impact of Glucosamine Supplementation on Gut Health.
Nutrients.
2021 Jun; 13(7):. doi:
10.3390/nu13072180. [PMID: 34202877] - Lei Fang, Liangzhuo Lin, Yang Lv, Zexin Huang, Xiaodong Lin, Xin Wang, Bojian Chen. The mechanism of aerobic exercise combined with glucosamine therapy and circUNK in improving knee osteoarthritis in rabbits.
Life sciences.
2021 Jun; 275(?):119375. doi:
10.1016/j.lfs.2021.119375. [PMID: 33737085] - William M Moore, Candace Chan, Toshiki Ishikawa, Emilie A Rennie, Heidi M-L Wipf, Veronica Benites, Maki Kawai-Yamada, Jenny C Mortimer, Henrik V Scheller. Reprogramming sphingolipid glycosylation is required for endosymbiont persistence in Medicago truncatula.
Current biology : CB.
2021 06; 31(11):2374-2385.e4. doi:
10.1016/j.cub.2021.03.067. [PMID: 33857428] - Cornelio Barrientos, Angélica Pérez, Jorge Vázquez. Ameliorative Effects of Oral Glucosamine on Insulin Resistance and Pancreatic Tissue Damage in Experimental Wistar rats on a High-fat Diet.
Comparative medicine.
2021 06; 71(3):215-221. doi:
10.30802/aalas-cm-21-000009. [PMID: 34082859] - Raushan Kumar, Komal Saraswat, Syed Ibrahim Rizvi. Glucosamine Displays a Potent Caloric Restriction Mimetic Effect in Senescent Rats by Activating Mitohormosis.
Rejuvenation research.
2021 Jun; 24(3):220-226. doi:
10.1089/rej.2020.2399. [PMID: 33478352] - Jin Zhang, Ruiyi Ge, Ziquan Yang. Effect of celecoxib combined with glucosamine hydrochloride in promoting the functional recovery and decreasing the inflammatory factor levels in patients with knee osteoarthritis.
Pakistan journal of pharmaceutical sciences.
2021 May; 34(3(Special)):1277-1282. doi:
NULL. [PMID: 34602400] - Boon Hooi Tan, Nafees Ahemad, Yan Pan, Uma Devi Palanisamy, Iekhsan Othman, Chin Eng Ong. In vitro inhibitory effects of glucosamine, chondroitin and diacerein on human hepatic CYP2D6.
Drug metabolism and personalized therapy.
2021 04; 36(4):259-270. doi:
10.1515/dmpt-2020-0182. [PMID: 34821124] - Chhavi Asthana, Gregory M Peterson, Madhur D Shastri, Rahul P Patel. Variation in the pharmacokinetics of glucosamine in healthy individuals.
Rheumatology (Oxford, England).
2021 03; 60(3):1205-1209. doi:
10.1093/rheumatology/keaa418. [PMID: 32901283] - Mingxing Luo, Fangfang Xu, Qingze Wang, Wenli Luo. The inhibiting effect of glucosamine sulfate combined with loxoprofen sodium on chondrocyte apoptosis in rats with knee osteoarthritis.
Journal of musculoskeletal & neuronal interactions.
2021 03; 21(1):113-120. doi:
NULL. [PMID: 33657761] - Waliul Islam, Yoshitaka Matsumoto, Jun Fang, Ayaka Harada, Takuro Niidome, Katsuhiko Ono, Hiroyasu Tsutsuki, Tomohiro Sawa, Takahisa Imamura, Kazuo Sakurai, Nobuyoshi Fukumitsu, Hirofumi Yamamoto, Hiroshi Maeda. Polymer-conjugated glucosamine complexed with boric acid shows tumor-selective accumulation and simultaneous inhibition of glycolysis.
Biomaterials.
2021 02; 269(?):120631. doi:
10.1016/j.biomaterials.2020.120631. [PMID: 33450582] - Julian E A Leakey, A Afshan Ali, Amy R Babb, Heidi L Badgley, Kelly J Davis, Beth E Juliar, Tatiana I Leakey, Sherry M Lewis, Ralph E Patton, John E Seng. Subchronic toxicity evaluation of glucosamine and glucosamine in combination with chondroitin sulfate in obese Zucker rats.
Toxicology and applied pharmacology.
2021 02; 412(?):115371. doi:
10.1016/j.taap.2020.115371. [PMID: 33345901] - Yi Chen, Wenquan Hu, Qi Li, Shiwei Zhao, Dan Zhao, Shuang Zhang, Zhuo Wei, Xiaoxiao Yang, Yuanli Chen, Xiaoju Li, Chenzhong Liao, Jihong Han, Qing Robert Miao, Yajun Duan. NGBR is required to ameliorate type 2 diabetes in mice by enhancing insulin sensitivity.
The Journal of biological chemistry.
2021 Jan; 296(?):100624. doi:
10.1016/j.jbc.2021.100624. [PMID: 33812996] - Chiara Caterino, Federica Aragosa, Giovanni Della Valle, Dario Costanza, Francesco Lamagna, Alfonso Piscitelli, Annalisa Nieddu, Gerardo Fatone. Clinical efficacy of Curcuvet and Boswellic acid combined with conventional nutraceutical product: An aid to canine osteoarthritis.
PloS one.
2021; 16(5):e0252279. doi:
10.1371/journal.pone.0252279. [PMID: 34048452] - Jingsheng Liu, Xiaoli Dong, Yining Liu, Kai Wang, Shuanhu Lei, Mingxuan Yang, Haiyuan Yue, Haijun Feng, Kai Feng, Kang Li, Jianwei Zhou, Yanqiang Chen, Wenjia Du, Xuewen Kang, Yayi Xia. The Identified Hub Gene GlcN in Osteoarthritis Progression and Treatment.
Computational and mathematical methods in medicine.
2021; 2021(?):5499450. doi:
10.1155/2021/5499450. [PMID: 34754325] - Zbigniew Żęgota, Joanna Goździk, Joanna Głogowska-Szeląg. EFFICACY OF HERBAL AND NATURALLY-DERIVED DIETARY SUPPLEMENTS FOR THE MANAGEMENT OF KNEE OSTEOARTHRITIS: A MINI-REVIEW.
Wiadomosci lekarskie (Warsaw, Poland : 1960).
2021; 74(8):1975-1983. doi:
. [PMID: 34537753] - Anna Starzyńska-Janiszewska, Robert Duliński, Bożena Stodolak. Fermentation with Edible Rhizopus Strains to Enhance the Bioactive Potential of Hull-Less Pumpkin Oil Cake.
Molecules (Basel, Switzerland).
2020 Dec; 25(24):. doi:
10.3390/molecules25245782. [PMID: 33302391] - Rianne A G Harmsen, Berit Bjugan Aam, Jogi Madhuprakash, Anne Grethe Hamre, Ethan D Goddard-Borger, Stephen G Withers, Vincent G H Eijsink, Morten Sørlie. Chemoenzymatic Synthesis of Chito-oligosaccharides with Alternating N-d-Acetylglucosamine and d-Glucosamine.
Biochemistry.
2020 12; 59(48):4581-4590. doi:
10.1021/acs.biochem.0c00839. [PMID: 33213137] - Ping Lin, Jia-Cheng Zeng, Ji-Guang Chen, Xu-Liang Nie, En Yuan, Xiao-Qiang Wang, Da-Yong Peng, Zhong-Ping Yin. Synthesis, in vitro inhibitory activity, kinetic study and molecular docking of novel N-alkyl-deoxynojirimycin derivatives as potential α-glucosidase inhibitors.
Journal of enzyme inhibition and medicinal chemistry.
2020 Dec; 35(1):1879-1890. doi:
10.1080/14756366.2020.1826941. [PMID: 33003963] - Yoshihiro Seto, Takuya Yoshihashi, Mari Tomonari, Hideto To. Absorption of glucosamine is improved by considering circadian rhythm and feeding time in rats.
Chronobiology international.
2020 11; 37(11):1528-1537. doi:
10.1080/07420528.2020.1784189. [PMID: 32576047] - Niels R M Reintjens, Elena Tondini, Ana R de Jong, Nico J Meeuwenoord, Fabrizio Chiodo, Evert Peterse, Herman S Overkleeft, Dmitri V Filippov, Gijsbert A van der Marel, Ferry Ossendorp, Jeroen D C Codée. Self-Adjuvanting Cancer Vaccines from Conjugation-Ready Lipid A Analogues and Synthetic Long Peptides.
Journal of medicinal chemistry.
2020 10; 63(20):11691-11706. doi:
10.1021/acs.jmedchem.0c00851. [PMID: 32960056] - Aman Khanna, Sivadasan Syam Das, Thozhuthum Parambil Smina, Jestin V Thomas, Ajaikumar B Kunnumakkara, Balu Maliakel, Illathu Madhavamenon Krishnakumar, Ratheesh Mohanan. Curcumagalactomannoside/Glucosamine Combination Improved Joint Health Among Osteoarthritic Subjects as Compared to Chondroitin Sulfate/Glucosamine: Double-Blinded, Randomized Controlled Study.
Journal of alternative and complementary medicine (New York, N.Y.).
2020 Oct; 26(10):945-955. doi:
10.1089/acm.2020.0128. [PMID: 32678677] - Jiwon Park, Yunkyoung Lee, Eun-Hye Jung, Sang-Min Kim, Hyeongjin Cho, Inn-Oc Han. Glucosamine regulates hepatic lipid accumulation by sensing glucose levels or feeding states of normal and excess.
Biochimica et biophysica acta. Molecular and cell biology of lipids.
2020 10; 1865(10):158764. doi:
10.1016/j.bbalip.2020.158764. [PMID: 32663610] - Hardik Naik Jinal, Natrajan Amaresan. In Silico and In Vitro Analyses of Glucosamine and Indole Acetaldehyde Inhibit Pathogenic Regulator Gene phcA of Ralstonia solanacearum, a Causative Agent of Bacterial Wilt of Tomato.
Applied biochemistry and biotechnology.
2020 Sep; 192(1):230-242. doi:
10.1007/s12010-020-03328-4. [PMID: 32367442] - Atanasio Pandiella-Alonso, Elena Díaz-Rodríguez, Eduardo Sanz. Antitumoral Properties of the Nutritional Supplement Ocoxin Oral Solution: A Comprehensive Review.
Nutrients.
2020 Aug; 12(9):. doi:
10.3390/nu12092661. [PMID: 32878230] - Chhavi Asthana, Gregory M Peterson, Madhur D Shastri, Graeme Jones, Rahul P Patel. Variation in Plasma Levels of Glucosamine With Chronic Dosing: A Possible Reason for Inconsistent Clinical Outcomes in Osteoarthritis.
Clinical therapeutics.
2020 08; 42(8):e140-e149. doi:
10.1016/j.clinthera.2020.06.009. [PMID: 32713600] - Nazafarin Satari, Somayeh Taymouri, Jaleh Varshosaz, Mahboubeh Rostami, Mina Mirian. Preparation and evaluation of inhalable dry powder containing glucosamine-conjugated gefitinib SLNs for lung cancer therapy.
Drug development and industrial pharmacy.
2020 Aug; 46(8):1265-1277. doi:
10.1080/03639045.2020.1788063. [PMID: 32594775] - S M Heffernan, C McCarthy, S Eustace, R E FitzPatrick, E Delahunt, G De Vito. Mineral rich algae with pine bark improved pain, physical function and analgesic use in mild-knee joint osteoarthritis, compared to Glucosamine: A randomized controlled pilot trial.
Complementary therapies in medicine.
2020 May; 50(?):102349. doi:
10.1016/j.ctim.2020.102349. [PMID: 32444040] - Yong Sun, Changde Wang, Chunzhu Gong. Repairing effects of glucosamine sulfate in combination with etoricoxib on articular cartilages of patients with knee osteoarthritis.
Journal of orthopaedic surgery and research.
2020 Apr; 15(1):150. doi:
10.1186/s13018-020-01648-z. [PMID: 32299482] - Yu Fu, Jing Liu, Wei Zhang, Sandra S Wæhrens, Marie Tøstesen, Erik T Hansen, Wender L P Bredie, René Lametsch. Exopeptidase treatment combined with Maillard reaction modification of protein hydrolysates derived from porcine muscle and plasma: Structure-taste relationship.
Food chemistry.
2020 Feb; 306(?):125613. doi:
10.1016/j.foodchem.2019.125613. [PMID: 31610331] - Mark W Grzanna, Rebecca Y Au, Angela Y Au, Ann M Rashmir, Carmelita G Frondoza. Avocado/Soybean Unsaponifiables, Glucosamine and Chondroitin Sulfate Combination Inhibits Proinflammatory COX-2 Expression and Prostaglandin E2 Production in Tendon-Derived Cells.
Journal of medicinal food.
2020 Feb; 23(2):139-146. doi:
10.1089/jmf.2019.0022. [PMID: 31486703] - Chhavi Asthana, Gregory M Peterson, Madhur D Shastri, Rahul P Patel. A novel and sensitive HILIC-CAD method for glucosamine quantification in plasma and its application to a human pharmacokinetic study.
Journal of pharmaceutical and biomedical analysis.
2020 Jan; 178(?):112954. doi:
10.1016/j.jpba.2019.112954. [PMID: 31704130] - Sven Basa, Malathi Nampally, Talita Honorato, Subha N Das, Appa R Podile, Nour E El Gueddari, Bruno M Moerschbacher. The Pattern of Acetylation Defines the Priming Activity of Chitosan Tetramers.
Journal of the American Chemical Society.
2020 01; 142(4):1975-1986. doi:
10.1021/jacs.9b11466. [PMID: 31895979] - Weiwei Wang, Junting Fan, Guang Zhu, Jing Wang, Yumei Qian, Hongxia Li, Jianming Ju, Lingling Shan. Targeted Prodrug-Based Self-Assembled Nanoparticles for Cancer Therapy.
International journal of nanomedicine.
2020; 15(?):2921-2933. doi:
10.2147/ijn.s247443. [PMID: 32425524] - Sandi L Navarro, Marta Herrero, Helena Martinez, Yuzheng Zhang, Jon Ladd, Edward Lo, David Shelley, Timothy W Randolph, Johanna W Lampe, Paul D Lampe. Differences in Serum Biomarkers Between Combined Glucosamine and Chondroitin Versus Celecoxib in a Randomized, Double-blind Trial in Osteoarthritis Patients.
Anti-inflammatory & anti-allergy agents in medicinal chemistry.
2020; 19(2):190-201. doi:
10.2174/1871523018666190115094512. [PMID: 30648524] - Marika Cordaro, Rosalba Siracusa, Daniela Impellizzeri, Ramona D' Amico, Alessio Filippo Peritore, Rosalia Crupi, Enrico Gugliandolo, Roberta Fusco, Rosanna Di Paola, Carlo Schievano, Salvatore Cuzzocrea. Safety and efficacy of a new micronized formulation of the ALIAmide palmitoylglucosamine in preclinical models of inflammation and osteoarthritis pain.
Arthritis research & therapy.
2019 11; 21(1):254. doi:
10.1186/s13075-019-2048-y. [PMID: 31779692] - Antonietta Stellavato, Odile Francesca Restaino, Valentina Vassallo, Rosario Finamore, Carlo Ruosi, Elisabetta Cassese, Mario De Rosa, Chiara Schiraldi. Comparative Analyses of Pharmaceuticals or Food Supplements Containing Chondroitin Sulfate: Are Their Bioactivities Equivalent?.
Advances in therapy.
2019 11; 36(11):3221-3237. doi:
10.1007/s12325-019-01064-8. [PMID: 31494830] - Qinyuan Ma, Xiuzhen Gao. Categories and biomanufacturing methods of glucosamine.
Applied microbiology and biotechnology.
2019 Oct; 103(19):7883-7889. doi:
10.1007/s00253-019-10084-x. [PMID: 31440792] - Hanke van der Wel, Elisabet Gas-Pascual, Christopher M West. Skp1 isoforms are differentially modified by a dual function prolyl 4-hydroxylase/N-acety lglucosaminyltransferase in a plant pathogen.
Glycobiology.
2019 09; 29(10):705-714. doi:
10.1093/glycob/cwz049. [PMID: 31281925] - Adriana C Casabuono, Federico Sisti, Julieta Fernández, Daniela Hozbor, Alicia S Couto. Bordetella bronchiseptica Glycosyltransferase Core Mutants Trigger Changes in Lipid A Structure.
Journal of the American Society for Mass Spectrometry.
2019 Sep; 30(9):1679-1689. doi:
10.1007/s13361-019-02233-3. [PMID: 31190311] - Yichen Ge, Nina Zheng, Xushen Chen, Jinqiu Zhu, Wei Sun, James R Olson, Diana S Aga, Wei Hu, Xiaojiang Tang, Xuefeng Ren. GMDTC Chelating Agent Attenuates Cisplatin-Induced Systemic Toxicity without Affecting Antitumor Efficacy.
Chemical research in toxicology.
2019 08; 32(8):1572-1582. doi:
10.1021/acs.chemrestox.9b00097. [PMID: 31240907] - Vu Van Loi, Nguyen Thi Thu Huyen, Tobias Busche, Quach Ngoc Tung, Martin Clemens Horst Gruhlke, Jörn Kalinowski, Jörg Bernhardt, Alan John Slusarenko, Haike Antelmann. Staphylococcus aureus responds to allicin by global S-thioallylation - Role of the Brx/BSH/YpdA pathway and the disulfide reductase MerA to overcome allicin stress.
Free radical biology & medicine.
2019 08; 139(?):55-69. doi:
10.1016/j.freeradbiomed.2019.05.018. [PMID: 31121222] - Shoko Kashiuchi, Rikako Miyazawa, Honoka Nagata, Mayu Shirai, Muneshige Shimizu, Hideyuki Sone, Shin Kamiyama. Effects of administration of glucosamine and chicken cartilage hydrolysate on rheumatoid arthritis in SKG mice.
Food & function.
2019 Aug; 10(8):5008-5017. doi:
10.1039/c9fo00981g. [PMID: 31355395] - Isao Nagaoka, Akifumi Tsuruta, Masafumi Yoshimura. Chondroprotective action of glucosamine, a chitosan monomer, on the joint health of athletes.
International journal of biological macromolecules.
2019 Jul; 132(?):795-800. doi:
10.1016/j.ijbiomac.2019.03.234. [PMID: 30940583] - Osvaldo Daniel Messina, Maritza Vidal Wilman, Luis F Vidal Neira. Nutrition, osteoarthritis and cartilage metabolism.
Aging clinical and experimental research.
2019 Jun; 31(6):807-813. doi:
10.1007/s40520-019-01191-w. [PMID: 30982220] - Desirée Josefine Artmann, Werner Amrain, Adele Murauer, Markus Ganzera, Pamela Vrabl, Christoph Walter Schinagl, Wolfgang Burgstaller. Critical evaluation of a putative glucosamine excretion by Aspergillus niger CBS120.49 and Penicillium ochrochloron CBS123.824 under citric acid producing conditions.
Scientific reports.
2019 05; 9(1):7496. doi:
10.1038/s41598-019-43976-z. [PMID: 31097735] - Mona Doshi, Daniel A Nierenberg, Orielyz Flores-Fernandez, Pragney Deme, Edilu Becerra, Annette R Khaled, Sampath Parthasarathy. Cypate and Cypate-Glucosamine as Near-Infrared Fluorescent Probes for In Vivo Tumor Imaging.
Molecular pharmacology.
2019 05; 95(5):475-489. doi:
10.1124/mol.118.114199. [PMID: 30842252] - Chun-Man Huang, Syue-Yi Lyu, Kuan-Hung Lin, Chun-Liang Chen, Mei-Hua Chen, Hao-Wei Shih, Ning-Shian Hsu, I-Wen Lo, Yung-Lin Wang, Yi-Shan Li, Chang-Jer Wu, Tsung-Lin Li. Teicoplanin Reprogrammed with the N-Acyl-Glucosamine Pharmacophore at the Penultimate Residue of Aglycone Acquires Broad-Spectrum Antimicrobial Activities Effectively Killing Gram-Positive and -Negative Pathogens.
ACS infectious diseases.
2019 03; 5(3):430-442. doi:
10.1021/acsinfecdis.8b00317. [PMID: 30599088] - Sukit Saengnipanthkul, Saranatra Waikakul, Sattaya Rojanasthien, Kitti Totemchokchyakarn, Attarit Srinkapaibulaya, Tai Cheh Chin, Nguyen Mai Hong, Olivier Bruyère, Cyrus Cooper, Jean-Yves Reginster, Myat Lwin. Differentiation of patented crystalline glucosamine sulfate from other glucosamine preparations will optimize osteoarthritis treatment.
International journal of rheumatic diseases.
2019 Mar; 22(3):376-385. doi:
10.1111/1756-185x.13068. [PMID: 28332780] - Qian Guo, Hailong Hu, Ying Zhou, Yuheng Yan, Xiangjuan Wei, Xingpei Fan, Daqian Yang, Hongjuan He, Yuri Oh, Kun Chen, Qiong Wu, Chuanpeng Liu, Ning Gu. Glucosamine induces increased musclin gene expression through endoplasmic reticulum stress-induced unfolding protein response signaling pathways in mouse skeletal muscle cells.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2019 Mar; 125(?):95-105. doi:
10.1016/j.fct.2018.12.051. [PMID: 30602124] - Ashley N Stewart, Stefanie Y Tan, David J Clark, Hui Zhang, G William Wong. N-Linked Glycosylation-Dependent and -Independent Mechanisms Regulating CTRP12 Cleavage, Secretion, and Stability.
Biochemistry.
2019 02; 58(6):727-741. doi:
10.1021/acs.biochem.8b00528. [PMID: 30566828] - Nuraniye Eruygur, Emrah Dural. Determination of 1-Deoxynojirimycin by a developed and validated HPLC-FLD method and assessment of In-vitro antioxidant, α-Amylase and α-Glucosidase inhibitory activity in mulberry varieties from Turkey.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2019 Feb; 53(?):234-242. doi:
10.1016/j.phymed.2018.09.016. [PMID: 30668403] - Gracjana Klein, Satish Raina. Regulated Assembly of LPS, Its Structural Alterations and Cellular Response to LPS Defects.
International journal of molecular sciences.
2019 Jan; 20(2):. doi:
10.3390/ijms20020356. [PMID: 30654491] - Chika Suzukamo, Kotomi Ishimaru, Ryuji Ochiai, Noriko Osaki, Tatsuya Kato. Milk-Fat Globule Membrane Plus Glucosamine Improves Joint Function and Physical Performance: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study.
Journal of nutritional science and vitaminology.
2019; 65(3):242-250. doi:
10.3177/jnsv.65.242. [PMID: 31257264] - Mark F McCarty, James H O'Keefe, James J DiNicolantonio. Glucosamine for the Treatment of Osteoarthritis: The Time Has Come for Higher-Dose Trials.
Journal of dietary supplements.
2019; 16(2):179-192. doi:
10.1080/19390211.2018.1448920. [PMID: 29667462] - Kyrylo V Makolinets, Vasyl I Makolinets, Dmytro V Morozenko, Kateryna V Gliebova, Svitlana I Danylchenko. Dynamics of biochemical markers of connective tissue metabolism in patients with knee osteoarthritis during conservative treatment with laser therapy.
Wiadomosci lekarskie (Warsaw, Poland : 1960).
2019; 72(5 cz 1):802-806. doi:
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Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology.
2019; 21(4):190-195. doi:
10.1080/14764172.2018.1502454. [PMID: 30040516] - Jaromir Jarecki. [Cartilage ageing and treatment possibilities].
Wiadomosci lekarskie (Warsaw, Poland : 1960).
2019; 72(9 cz 1):1671-1675. doi:
10.36740/wlek201909112. [PMID: 31586981] - Azidah Abdul Kadir, Arifah Abdul Kadir, Roslida Abd Hamid, Abdul Manan Mat Jais, Julia Omar, Abdul Nawfar Sadagatullah, Salziyan Badrin, Thin Thin Win, K N S Sirajudeen, Annas Salleh. Evaluation of Chondroprotective Activity of Channa striatus in Rabbit Osteoarthritis Model.
BioMed research international.
2019; 2019(?):6979585. doi:
10.1155/2019/6979585. [PMID: 31355276] - Imen Abbes, Christophe Rihouey, Julie Hardouin, Thierry Jouenne, Emmanuelle De, Stéphane Alexandre. Identification by mass spectrometry of glucosaminylphosphatidylglycerol, a phosphatidylglycerol derivative, produced by Pseudomonas aeruginosa.
Rapid communications in mass spectrometry : RCM.
2018 Dec; 32(24):2113-2121. doi:
10.1002/rcm.8277. [PMID: 30171632] - Ki Eun Pyo, Chang Rok Kim, Minkyoung Lee, Jong-Seo Kim, Keun Il Kim, Sung Hee Baek. ULK1 O-GlcNAcylation Is Crucial for Activating VPS34 via ATG14L during Autophagy Initiation.
Cell reports.
2018 12; 25(10):2878-2890.e4. doi:
10.1016/j.celrep.2018.11.042. [PMID: 30517873] - Akifumi Tsuruta, Takumi Horiike, Masafumi Yoshimura, Isao Nagaoka. Evaluation of the effect of the administration of a glucosamine‑containing supplement on biomarkers for cartilage metabolism in soccer players: A randomized double‑blind placebo‑controlled study.
Molecular medicine reports.
2018 Oct; 18(4):3941-3948. doi:
10.3892/mmr.2018.9396. [PMID: 30132529] - Yves Henrotin, Ali Mobasheri. Natural Products for Promoting Joint Health and Managing Osteoarthritis.
Current rheumatology reports.
2018 09; 20(11):72. doi:
10.1007/s11926-018-0782-9. [PMID: 30232562] - Wei Dai, Chang Qi, Shasha Wang. Synergistic effect of glucosamine and vitamin E against experimental rheumatoid arthritis in neonatal rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Sep; 105(?):835-840. doi:
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European review for medical and pharmacological sciences.
2018 09; 22(17):5424-5428. doi:
10.26355/eurrev_201809_15801. [PMID: 30229812] - Xuran Zhang, Qing Ruan, Xiaojiang Duan, Qianqian Gan, Xiaoqing Song, Sian Fang, Xiao Lin, Jin Du, Junbo Zhang. Novel 99mTc-Labeled Glucose Derivative for Single Photon Emission Computed Tomography: A Promising Tumor Imaging Agent.
Molecular pharmaceutics.
2018 08; 15(8):3417-3424. doi:
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American heart journal.
2018 08; 202(?):27-32. doi:
10.1016/j.ahj.2018.04.003. [PMID: 29803983] - Vi T Dang, Lexy H Zhong, Aric Huang, Arlinda Deng, Geoff H Werstuck. Glycosphingolipids promote pro-atherogenic pathways in the pathogenesis of hyperglycemia-induced accelerated atherosclerosis.
Metabolomics : Official journal of the Metabolomic Society.
2018 07; 14(7):92. doi:
10.1007/s11306-018-1392-2. [PMID: 30830446] - Yuhuan Ma, Wenwei Zheng, Houhuang Chen, Xiang Shao, Pingdong Lin, Xianxiang Liu, Xihai Li, Hongzhi Ye. Glucosamine promotes chondrocyte proliferation via the Wnt/β‑catenin signaling pathway.
International journal of molecular medicine.
2018 Jul; 42(1):61-70. doi:
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Scientific reports.
2018 06; 8(1):9046. doi:
10.1038/s41598-018-27418-w. [PMID: 29899359] - Yali Li, Liang Chen, Yangyang Liu, Yong Zhang, Yunxiang Liang, Yuxia Mei. Anti-inflammatory effects in a mouse osteoarthritis model of a mixture of glucosamine and chitooligosaccharides produced by bi-enzyme single-step hydrolysis.
Scientific reports.
2018 04; 8(1):5624. doi:
10.1038/s41598-018-24050-6. [PMID: 29618773] - Charles A Chang, Babatope Akinbobuyi, Jeremy M Quintana, Gumpei Yoshimatsu, Bashoo Naziruddin, Robert R Kane. Ex-vivo generation of drug-eluting islets improves transplant outcomes by inhibiting TLR4-Mediated NFkB upregulation.
Biomaterials.
2018 03; 159(?):13-24. doi:
10.1016/j.biomaterials.2017.12.020. [PMID: 29309990] - Chun-Lu Yan, Sheng-Hua Li, Fang-Yu An, Yong-Qi Liu, Peng-Fei Xia, Zheng-Min Ma, Yan-Qiang Niu, Peng-Yao Liu. [The therapeutic effects of Yougui pill on knee osteoarthritis and the expression of Wnt signal pathway related factors in rats].
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology.
2018 Feb; 34(2):177-181. doi:
10.12047/j.cjap.5603.2018.043. [PMID: 29926686] - Olivier Bruyère, Cyrus Cooper, Nasser M Al-Daghri, Elaine M Dennison, René Rizzoli, Jean-Yves Reginster. Inappropriate claims from non-equivalent medications in osteoarthritis: a position paper endorsed by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO).
Aging clinical and experimental research.
2018 Feb; 30(2):111-117. doi:
10.1007/s40520-017-0861-1. [PMID: 29177637] - Robert J Nash, Boris Kg Azantsa, Hazel Sharp, Velmurugan Shanmugham. Effectiveness of Cucumis sativus extract versus glucosamine-chondroitin in the management of moderate osteoarthritis: a randomized controlled trial.
Clinical interventions in aging.
2018; 13(?):2119-2126. doi:
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Drug design, development and therapy.
2018; 12(?):3071-3084. doi:
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