hydroxychloroquine (BioDeep_00000409845)

Main id: BioDeep_00000004015

 


代谢物信息卡片


hydroxychloroquine

化学式: C18H26ClN3O (335.1764296)
中文名称: 硫酸羟氯喹
谱图信息: 最多检出来源 Homo sapiens(urine) 7.69%

分子结构信息

SMILES: CCN(CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl)CCO
InChI: InChI=1S/C18H26ClN3O/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21)

描述信息

P - Antiparasitic products, insecticides and repellents > P01 - Antiprotozoals > P01B - Antimalarials > P01BA - Aminoquinolines
COVID info from Guide to PHARMACOLOGY, clinicaltrial, clinicaltrials, clinical trial, clinical trials
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C277 - Antiprotozoal Agent
D018501 - Antirheumatic Agents
D004791 - Enzyme Inhibitors
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
CONFIDENCE standard compound; INTERNAL_ID 2741

同义名列表

1 个代谢物同义名

hydroxychloroquine



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Lufei Yang, Yuanyuan Liang, Jincheng Pu, Li Cai, Ronglin Gao, Fang Han, Keni Chang, Shengnan Pan, Zhenzhen Wu, Youwei Zhang, Yanqing Wang, Jiamin Song, Huihong Wu, Jianping Tang, Xuan Wang. Dysregulated serum lipid profile is associated with inflammation and disease activity in primary Sjögren's syndrome: a retrospective study in China. Immunology letters. 2024 Jun; 267(?):106865. doi: 10.1016/j.imlet.2024.106865. [PMID: 38705483]
  • Ke Ding, Hailong Tian, Lei Li, Zhihan Wang, Shanshan Liu, Ning Ding, Edouard C Nice, Canhua Huang, Jinku Bao, Wei Gao, Zheng Shi. Drug repurposing-based nanoplatform via modulating autophagy to enhance chemo-phototherapy against colorectal cancer. Journal of nanobiotechnology. 2024 Apr; 22(1):202. doi: 10.1186/s12951-024-02416-5. [PMID: 38658952]
  • Ji-Peng Peng, Xiao-Yu Yang, Feng Luo, Xue-Mei Yuan, Hong Xiong, Wu-Kai Ma, Xue-Ming Yao. Hydroxychloroquine-induced hyperpigmentation of the skin and bull's-eye maculopathy in rheumatic patients: a case report and literature review. Frontiers in immunology. 2024; 15(?):1383343. doi: 10.3389/fimmu.2024.1383343. [PMID: 38660312]
  • Chaochao Wang, Xiaoqiao Cai, Shengfen Lin, Yongqiang Lin. Hydroxychloroquine ameliorates immune functionality and intestinal flora disorders of IgA nephropathy by inhibition of C1GALT1/Cosmc pathway. Immunopharmacology and immunotoxicology. 2023 Dec; ?(?):1-11. doi: 10.1080/08923973.2023.2300306. [PMID: 38151955]
  • Feng Luo, Xue-Mei Yuan, Hong Xiong, Chang-Ming Chen, Wu-Kai Ma, Xue-Ming Yao. Acute generalized exanthematous pustulosis caused by hydroxychloroquine in a patient with rheumatoid arthritis and CARD14 mutation: Case report. Medicine. 2023 Nov; 102(47):e36168. doi: 10.1097/md.0000000000036168. [PMID: 38013380]
  • Liang Ee Low, Chee Kei Kong, Wei-Hsum Yap, Sangeetaprivya P Siva, Siew Hua Gan, Wei Sheng Siew, Long Chiau Ming, Ashley Sean Lai-Foenander, Sui Kiat Chang, Wai-Leng Lee, Yongjiang Wu, Kooi-Yeong Khaw, Yong Sze Ong, Beng Ti Tey, Sachin Kumar Singh, Kamal Dua, Dinesh Kumar Chellappan, Bey-Hing Goh. Hydroxychloroquine: Key therapeutic advances and emerging nanotechnological landscape for cancer mitigation. Chemico-biological interactions. 2023 Oct; 386(?):110750. doi: 10.1016/j.cbi.2023.110750. [PMID: 37839513]
  • Aiping Zhang, Shilei Chen, Riyang Lin. Combined use of total glucosides of paeony and hydroxychloroquine in primary Sjögren's syndrome: A systematic review. Immunity, inflammation and disease. 2023 10; 11(10):e1044. doi: 10.1002/iid3.1044. [PMID: 37904705]
  • Narjes Morovati Moez, Seyed Mostafa Hosseini, Fereshte Kalhori, Leili Shokoohizadeh, Mohammad Reza Arabestani. Co-delivery of streptomycin and hydroxychloroquine by labeled solid lipid nanoparticles to treat brucellosis: an animal study. Scientific reports. 2023 Aug; 13(1):14012. doi: 10.1038/s41598-023-41150-0. [PMID: 37640734]
  • Damien Barraud, Lonni Besançon, Elisabeth M Bik, Eric Billy, Franck Clarot, Fabrice Frank, Anthony Guihur, David Hajage, Karine Lacombe, Hervé Maisonneuve, Mathieu Molimard, Matthieu Mulot, Alexander Samuel. Why the article that led to the widespread use of hydroxychloroquine in COVID-19 should be retracted. Therapie. 2023 Jul; 78(4):437-440. doi: 10.1016/j.therap.2023.06.001. [PMID: 37321944]
  • Xiaohua Yang, Maria Forstner, Christina K Rapp, Ina Rothenaigner, Yang Li, Kamyar Hadian, Matthias Griese. ABCA3 Deficiency-Variant-Specific Response to Hydroxychloroquine. International journal of molecular sciences. 2023 May; 24(9):. doi: 10.3390/ijms24098179. [PMID: 37175887]
  • Kyeong-Eon Park, Soo Hee Lee, Sung Il Bae, Yeran Hwang, Seong-Ho Ok, Dawon Kang, Seung Hyun Ahn, Gyujin Sim, Jin Kyeong Park, Ju-Tae Sohn. Chloroquine inhibits vasodilation induced by ATP-sensitive potassium channels in isolated rat aorta. General physiology and biophysics. 2023 May; 42(3):297-306. doi: 10.4149/gpb_2023008. [PMID: 37098743]
  • Divya Kanchibhotla, Prateek Harsora, Saumya Subramanian, M Ravi Kumar Reddy, Hari K R Venkatesh. Rate of Recovery and Symptomatic Efficacy of a Polyherbal AYUSH Formulation in the Treatment of SARS-CoV-2 Disease: A Single-arm Trial. Alternative therapies in health and medicine. 2023 May; 29(4):134-139. doi: ". [PMID: 35951065]
  • Pravin Phadatare, Jayanta Debnath. Lysosomal lipid peroxidation mediates immunogenic cell death. The Journal of clinical investigation. 2023 04; 133(8):. doi: 10.1172/jci169240. [PMID: 37066873]
  • Rakesh C Kukreja, Rui Wang, Saisudha Koka, Anindita Das, Arun Samidurai, Lei Xi. Treating diabetes with combination of phosphodiesterase 5 inhibitors and hydroxychloroquine-a possible prevention strategy for COVID-19?. Molecular and cellular biochemistry. 2023 Mar; 478(3):679-696. doi: 10.1007/s11010-022-04520-2. [PMID: 36036333]
  • Sunipa Sarkar, Prashant Chandra Singh. Selective Action of Antimalarial Hydroxychloroquine on the Packing of Phospholipids and Interfacial Water Associated with Lysosomal Model Membranes: A Vibrational Sum Frequency Generation Study. Langmuir : the ACS journal of surfaces and colloids. 2023 02; 39(6):2435-2443. doi: 10.1021/acs.langmuir.2c03321. [PMID: 36735290]
  • Ling Shuai, Jiajie She, Ruiying Diao, Huihui Zhao, Xuemin Liu, Qingyu Hu, Dongdong Li, Danna Su, Xiaofeng Ye, Yan Guo, Mei Zhong, Liping Wang. Hydroxychloroquine protects against autoimmune premature ovarian insufficiency by modulating the Treg/Th17 cell ratio in BALB/c mice. American journal of reproductive immunology (New York, N.Y. : 1989). 2023 Feb; ?(?):e13686. doi: 10.1111/aji.13686. [PMID: 36752682]
  • Zahra Karimitabar, Zahra Chegini, Leili Shokoohizadeh, Narjes Morovati Moez, Mohammad Reza Arabestani, Seyed Mostafa Hosseini. Use of the quantum dot-labeled solid lipid nanoparticles for delivery of streptomycin and hydroxychloroquine: A new therapeutic approach for treatment of intracellular Brucella abortus infection. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Feb; 158(?):114116. doi: 10.1016/j.biopha.2022.114116. [PMID: 36527846]
  • Zhihang Yang, Yufan Du, Lei Lei, Xue Xia, Xiaorong Wang, Fan Tong, Yuan Li, Huile Gao. Co-delivery of ibrutinib and hydroxychloroquine by albumin nanoparticles for enhanced chemotherapy of glioma. International journal of pharmaceutics. 2023 Jan; 630(?):122436. doi: 10.1016/j.ijpharm.2022.122436. [PMID: 36436742]
  • Zheng-Ming Liao, Zhong-Min Zhang, Qi Liu. Hydroxychloroquine/chloroquine and the risk of acute kidney injury in COVID-19 patients: a systematic review and meta-analysis. Renal failure. 2022 Dec; 44(1):415-425. doi: 10.1080/0886022x.2022.2046609. [PMID: 35253579]
  • Tiantian Cai, Jing Zhao, Yanping Yang, Yanfei Jiang, Jin-An Zhang. Hydroxychloroquine use reduces mortality risk in systemic lupus erythematosus: A systematic review and meta-analysis of cohort studies. Lupus. 2022 Dec; 31(14):1714-1725. doi: 10.1177/09612033221129774. [PMID: 36325952]
  • Risa Wakiya, Kiyo Ueeda, Hiromi Shimada, Shusaku Nakashima, Tomohiro Kameda, Nobuyuki Miyatake, Mikiya Kato, Taichi Miyagi, Koichi Sugihara, Mao Mizusaki, Rina Mino, Norimitsu Kadowaki, Hiroaki Dobashi. Supplemental hydroxychloroquine therapy regulates adipokines in patients with systemic lupus erythematosus with stable disease. Clinical rheumatology. 2022 Nov; 41(11):3345-3353. doi: 10.1007/s10067-022-06282-0. [PMID: 35849246]
  • Haochen Guan, Huagang Lin, Xiaojun Wang, Ying Xu, Yuqi Zheng, Xun Zhou, Xuehong Diao, Zhibin Ye, Jing Xiao. Autophagy-dependent Na+-K+-ATPase signalling and abnormal urate reabsorption in hyperuricaemia-induced renal tubular injury. European journal of pharmacology. 2022 Oct; 932(?):175237. doi: 10.1016/j.ejphar.2022.175237. [PMID: 36063871]
  • Saba Ahmed, Justin Konig, Lora J Kasselman, Heather A Renna, Joshua De Leon, Steven E Carsons, Allison B Reiss. Hydroxychloroquine Effects on THP-1 Macrophage Cholesterol Handling: Cell Culture Studies Corresponding to the TARGET Cardiovascular Trial. Medicina (Kaunas, Lithuania). 2022 Sep; 58(9):. doi: 10.3390/medicina58091287. [PMID: 36143964]
  • Zixuan Yuan, Mahmud Arif Pavel, Hao Wang, Jerome C Kwachukwu, Sonia Mediouni, Joseph Anthony Jablonski, Kendall W Nettles, Chakravarthy B Reddy, Susana T Valente, Scott B Hansen. Hydroxychloroquine blocks SARS-CoV-2 entry into the endocytic pathway in mammalian cell culture. Communications biology. 2022 09; 5(1):958. doi: 10.1038/s42003-022-03841-8. [PMID: 36104427]
  • Kathryn R Hayden, Matthew Jones, Kyle R Elkin, Michael J Shreve, William Irvin Clees, Shirley Clark, Michael L Mashtare, Tamie L Veith, Herschel A Elliott, John E Watson, Justin Silverman, Thomas L Richard, Andrew F Read, Heather E Preisendanz. Impacts of the COVID-19 pandemic on pharmaceuticals in wastewater treated for beneficial reuse: Two case studies in central Pennsylvania. Journal of environmental quality. 2022 Sep; 51(5):1066-1082. doi: 10.1002/jeq2.20398. [PMID: 35919971]
  • Fiona Perelini, Joshua Agnew, Jonathan R Skinner, Dug Yeo Han, Ross Nicholson, Nigel Wilson. Revisiting QT prolongation in acute rheumatic fever - Relevance for hydroxychloroquine treatment. International journal of cardiology. 2022 Sep; 362(?):93-96. doi: 10.1016/j.ijcard.2022.05.053. [PMID: 35643214]
  • Fuxiaonan Zhao, Jianhai Wang, Qi Wang, Zhili Hou, Yingchao Zhang, Xue Li, Qi Wu, Huaiyong Chen. Organoid technology and lung injury mouse models evaluating effects of hydroxychloroquine on lung epithelial regeneration. Experimental animals. 2022 Aug; 71(3):316-328. doi: 10.1538/expanim.21-0168. [PMID: 35197405]
  • Changsong Lin, Ziyu Wang, Jie Li, Xinyi Xia, Yun Liu, Qianghu Wang. Implications of SARS-CoV-2 infection for patients with rheumatic disease. Annals of the rheumatic diseases. 2022 Aug; 81(8):e152. doi: 10.1136/annrheumdis-2020-218050. [PMID: 32792333]
  • Bhagteshwar Singh, Hannah Ryan, Tamara Kredo, Marty Chaplin, Tom Fletcher. Chloroquine or hydroxychloroquine for prevention and treatment of COVID-19. Emergencias : revista de la Sociedad Espanola de Medicina de Emergencias. 2022 Aug; 34(4):305-307. doi: NULL. [PMID: 35833770]
  • Pedro Santos-Moreno, Diana Buitrago-Garcia, Laura Villarreal, Anggie Aza, Michael Cabrera, Wilberto Rivero, Adriana Rojas-Villarraga. Emergency arising from patients' fear of taking antimalarials during these COVID-19 times: are antimalarials as unsafe for cardiovascular health as recent reports suggest?. Annals of the rheumatic diseases. 2022 Aug; 81(8):e154. doi: 10.1136/annrheumdis-2020-218259. [PMID: 32647029]
  • Alexis Mathian, Zahir Amoura. Response to 'Impact of COVID-19 pandemic on hospitalisation of patients with systemic lupus erythematosus (SLE): report from a tertiary hospital during the peak of the pandemic' by Chuah et al. Annals of the rheumatic diseases. 2022 Aug; 81(8):e145. doi: 10.1136/annrheumdis-2020-218487. [PMID: 32883652]
  • Jean W Liew, Elizabeth R Graef, Jeffrey A Sparks, Alfred Hyoungju Kim. Response to: 'Emergency arising from patients' fear of taking antimalarials during these COVID-19 times: are antimalarials as unsafe for cardiovascular health as recent reports suggest?' by Santos-Moreno et al. Annals of the rheumatic diseases. 2022 Aug; 81(8):e155. doi: 10.1136/annrheumdis-2020-218432. [PMID: 32647030]
  • Pawan Kumar Doharey, Vishal Singh, Mallikarjuna Rao Gedda, Amaresh Kumar Sahoo, Pritish Kumar Varadwaj, Bechan Sharma. In silico study indicates antimalarials as direct inhibitors of SARS-CoV-2-RNA dependent RNA polymerase. Journal of biomolecular structure & dynamics. 2022 Aug; 40(12):5588-5605. doi: 10.1080/07391102.2021.1871956. [PMID: 33475021]
  • Shihui Li, Rong Ma, Xin-Yue Hu, Hua-Bin Li, Wen-Chao Geng, Xianglei Kong, Chao Zhang, Dong-Sheng Guo. Drug in Drug: A Host-Guest Formulation of Azocalixarene with Hydroxychloroquine for Synergistic Anti-Inflammation. Advanced materials (Deerfield Beach, Fla.). 2022 Aug; 34(32):e2203765. doi: 10.1002/adma.202203765. [PMID: 35680644]
  • Alexis Mathian, Zahir Amoura. Response to: 'Implications of SARS-CoV-2 infection for patients with rheumatic disease' by Lin et al. Annals of the rheumatic diseases. 2022 Aug; 81(8):e153. doi: 10.1136/annrheumdis-2020-218404. [PMID: 32895236]
  • Lucia Račková, Erika Csekes. Redox aspects of cytotoxicity and anti-neuroinflammatory profile of chloroquine and hydroxychloroquine in serum-starved BV-2 microglia. Toxicology and applied pharmacology. 2022 07; 447(?):116084. doi: 10.1016/j.taap.2022.116084. [PMID: 35618033]
  • Jonathan D Casey, Laura M Beskow, Jeremy Brown, Samuel M Brown, Étienne Gayat, Michelle Ng Gong, Michael O Harhay, Samir Jaber, Jacob C Jentzer, Pierre-François Laterre, John C Marshall, Michael A Matthay, Todd W Rice, Yves Rosenberg, Alison E Turnbull, Lorraine B Ware, Wesley H Self, Alexandre Mebazaa, Sean P Collins. Use of pragmatic and explanatory trial designs in acute care research: lessons from COVID-19. The Lancet. Respiratory medicine. 2022 07; 10(7):700-714. doi: 10.1016/s2213-2600(22)00044-3. [PMID: 35709825]
  • Marcelo M Pinheiro, Gecilmara S Pileggi, Adriana M Kakehasi, Ana Paula M Gomides Reis, Edgard Torres Reis-Neto, Mirhelen M Abreu, Cleandro P Albuquerque, Nafice C Araújo, Ana Beatriz Bacchiega, Dante V Bianchi, Blanca Bica, Eloisa Bonfa, Eduardo F Borba, Danielle C S Egypto Brito, Debora C Calderaro, Ângela L B Pinto Duarte, Rafaela C Espírito Santo, Paula R Fernandes, Mariana P Guimarães, Kirla W Poti Gomes, Gabriela G Faustino Ilana, Evandro M Klumb, Claudia D L Marques, Ana Karla Guedes de Melo, Odirlei A Monticielo, Licia M H Mota, Gabriela A Munhoz, Eduardo S Paiva, Helena L Alves Pereira, José Roberto Provenza, Sandra L Euzébio Ribeiro, Laurindo F Rocha, Emilia I Sato, Telma Skare, Viviane A de Souza, Valeria Valim, Marcus V G Lacerda, Ricardo M Xavier, Gilda A Ferreira. Incidence and risk factors for moderate/severe COVID-19 in rheumatic diseases patients on hydroxychloroquine: a 24-week prospective cohort. Clinical and experimental rheumatology. 2022 Jul; 40(7):1258-1266. doi: 10.55563/clinexprheumatol/67oyux. [PMID: 34251312]
  • Xiuge Gao, Xian Jing, Junqi Wang, Yuling Zheng, Yawei Qiu, Hui Ji, Lin Peng, Shanxiang Jiang, Wenda Wu, Dawei Guo. Safety considerations of chloroquine in the treatment of patients with diabetes and COVID-19. Chemico-biological interactions. 2022 Jul; 361(?):109954. doi: 10.1016/j.cbi.2022.109954. [PMID: 35469826]
  • Whitney J Westhoff, Louisa H Smith, Diego F Wyszynski, Sonia Hernandez-Diaz. COVID-19 pharmacotherapy utilization patterns during pregnancy: International Registry of Coronavirus Exposure in Pregnancy. Pharmacoepidemiology and drug safety. 2022 07; 31(7):804-809. doi: 10.1002/pds.5440. [PMID: 35426202]
  • Qin Shao, Liang Jin, Chengyin Li, Jing Wang, Miao Wang, Qin Wang, Bin Wu. Comparative analysis of the efficacy and safety of herbal decoction CheReCunJin alone and combined with hydroxychloroquine for treating primary Sjögren's syndrome: A randomized controlled trial. Explore (New York, N.Y.). 2022 Jul; 18(4):416-422. doi: 10.1016/j.explore.2021.08.002. [PMID: 34417112]
  • Mert Oztas, Murat Bektas, Ilker Karacan, Numune Aliyeva, Ayten Dag, Sarvan Aghamuradov, Selim Berke Cevirgen, Selma Sari, Murat Bolayirli, Gunay Can, Gulen Hatemi, Emire Seyahi, Huri Ozdogan, Ahmet Gul, Serdal Ugurlu. Frequency and severity of COVID-19 in patients with various rheumatic diseases treated regularly with colchicine or hydroxychloroquine. Journal of medical virology. 2022 07; 94(7):3431-3437. doi: 10.1002/jmv.27731. [PMID: 35315100]
  • Majid Ghafoori, Hassan Saadati, Mohammadreza Taghavi, Amir Azimian, Peiman Alesheikh, Mina Sadat Mohajerzadeh, Morteza Behnamfar, Marzieh Pakzad, Maryam Rameshrad. Survival of the hospitalized patients with COVID-19 receiving atorvastatin: A randomized clinical trial. Journal of medical virology. 2022 Jul; 94(7):3160-3168. doi: 10.1002/jmv.27710. [PMID: 35274326]
  • Susanna Croci, Mary Anna Venneri, Stefania Mantovani, Chiara Fallerini, Elisa Benetti, Nicola Picchiotti, Federica Campolo, Francesco Imperatore, Maria Palmieri, Sergio Daga, Chiara Gabbi, Francesca Montagnani, Giada Beligni, Ticiana D J Farias, Miriam Lucia Carriero, Laura Di Sarno, Diana Alaverdian, Sigrid Aslaksen, Maria Vittoria Cubellis, Ottavia Spiga, Margherita Baldassarri, Francesca Fava, Paul J Norman, Elisa Frullanti, Andrea M Isidori, Antonio Amoroso, Francesca Mari, Simone Furini, Mario U Mondelli, Gen-Covid Multicenter Study, Mario Chiariello, Alessandra Renieri, Ilaria Meloni. The polymorphism L412F in TLR3 inhibits autophagy and is a marker of severe COVID-19 in males. Autophagy. 2022 07; 18(7):1662-1672. doi: 10.1080/15548627.2021.1995152. [PMID: 34964709]
  • A Dubois, A Féral, J-B Pain, J Michot, D Fansi Ndengoue, A Benomar, E Clou, I Debrix. [Treatments for SARS-CoV-2 infection: A retrospective study of drug-drug interactions and safety]. Annales pharmaceutiques francaises. 2022 Jul; 80(4):531-542. doi: 10.1016/j.pharma.2021.11.001. [PMID: 34748737]
  • M Vitrone, F Mele, E Durante-Mangoni, R Zampino. Drugs and liver injury: a not to be overlooked binomial in COVID-19. Journal of chemotherapy (Florence, Italy). 2022 Jul; 34(4):207-220. doi: 10.1080/1120009x.2021.1988203. [PMID: 34644236]
  • Sezin Erarpat, Süleyman Bodur, Miray Öner, Ömer Tahir Günkara, Sezgin Bakırdere. A simple and efficient derivatization strategy combined with switchable solvent liquid-liquid microextraction hydroxychloroquine methyl acetate-d3 -based quadruple isotope dilution gas chromatography mass spectrometry for the determination of hydroxychloroquine sulfate in biological fluids. Rapid communications in mass spectrometry : RCM. 2022 Jun; 36(12):e9282. doi: 10.1002/rcm.9282. [PMID: 35229402]
  • Pepa Bruce, Kate Ainscough, Lee Hatter, Irene Braithwaite, Lindsay R Berry, Mark Fitzgerald, Thomas Hills, Kathy Brickell, David Cosgrave, Alex Semprini, Susan Morpeth, Scott Berry, Peter Doran, Paul Young, Richard Beasley, Alistair Nichol. Prophylaxis in healthcare workers during a pandemic: a model for a multi-centre international randomised controlled trial using Bayesian analyses. Trials. 2022 Jun; 23(1):534. doi: 10.1186/s13063-022-06402-w. [PMID: 35761370]
  • Dengren Li, Kuipeng Yu, Feng Feng, Yang Zhang, Fang Bai, Yimeng Zhang, Nan Sun, Jiahui Fan, Lei Liu, Huimin Yang, Xiangdong Yang. Hydroxychloroquine alleviates renal interstitial fibrosis by inhibiting the PI3K/Akt signaling pathway. Biochemical and biophysical research communications. 2022 06; 610(?):154-161. doi: 10.1016/j.bbrc.2022.04.058. [PMID: 35462097]
  • Risa Wakiya, Kiyo Ueeda, Shusaku Nakashima, Hiromi Shimada, Tomohiro Kameda, Mai Mahmoud Fahmy Mansour, Mikiya Kato, Taichi Miyagi, Koichi Sugihara, Mao Mizusaki, Rina Mino, Norimitsu Kadowaki, Hiroaki Dobashi. Effect of add-on hydroxychloroquine therapy on serum proinflammatory cytokine levels in patients with systemic lupus erythematosus. Scientific reports. 2022 06; 12(1):10175. doi: 10.1038/s41598-022-14571-6. [PMID: 35715525]
  • Owen Dyer. Covid-19: Doctor who sold hydroxychloroquine as 'magic bullet' treatment is jailed. BMJ (Clinical research ed.). 2022 06; 377(?):o1395. doi: 10.1136/bmj.o1395. [PMID: 35667680]
  • Bharath Kumar Tirupakuzhi Vijayaraghavan, Vivekanand Jha, Dorrilyn Rajbhandari, Sheila Nainan Myatra, Arpita Ghosh, Amritendu Bhattacharya, Sumaiya Arfin, Abhinav Bassi, Lachlan Hugh Donaldson, Naomi E Hammond, Oommen John, Rohina Joshi, Mallikarjuna Kunigari, Cynthia Amrutha, Syed Haider Mehdi Husaini, Subir Ghosh, Santosh Kumar Nag, Hari Krishnan Selvaraj, Viny Kantroo, Kamal D Shah, Balasubramanian Venkatesh. Hydroxychloroquine plus personal protective equipment versus personal protective equipment alone for the prevention of laboratory-confirmed COVID-19 infections among healthcare workers: a multicentre, parallel-group randomised controlled trial from India. BMJ open. 2022 06; 12(6):e059540. doi: 10.1136/bmjopen-2021-059540. [PMID: 35649613]
  • Simona De Gregori, Francesco Falaschi, Alessia Ballesio, Alessandra Fusco, Elisa Cremonte, Roberta Canta, Umberto Sabatini, Mariadelfina Molinaro, Carlo Soffiantini, Alba Nardone, Alessandro Vicentini, Annalisa De Silvestri, Antonio Di Sabatino. Hydroxychloroquine Blood Concentrations Can Be Clinically Relevant Also After Drug Discontinuation. Drugs in R&D. 2022 Jun; 22(2):155-163. doi: 10.1007/s40268-022-00387-2. [PMID: 35553396]
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