Hydroxychloroquine (BioDeep_00000004015)
Secondary id: BioDeep_00000409845
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
7-Chloro-4-(4-(N-ethyl-N-beta-hydroxyethylamino)-1-methylbutylamino)quinoline
化学式: C18H26ClN3O (335.1764)
中文名称: 硫酸羟氯喹
谱图信息:
最多检出来源 Rattus norvegicus(blood) 3.12%
分子结构信息
SMILES: CCN(CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl)CCO
InChI: InChI=1S/C18H26ClN3O/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21)
描述信息
Hydroxychloroquine is only found in individuals that have used or taken this drug. It is a chemotherapeutic agent that acts against erythrocytic forms of malarial parasites.Although the exact mechanism of action is unknown, it may be based on ability of hydroxychloroquine to bind to and alter DNA. Hydroxychloroquine has also has been found to be taken up into the acidic food vacuoles of the parasite in the erythrocyte. This increases the pH of the acid vesicles, interfering with vesicle functions and possibly inhibiting phospholipid metabolism. In suppressive treatment, hydroxychloroquine inhibits the erythrocytic stage of development of plasmodia. In acute attacks of malaria, it interrupts erythrocytic schizogony of the parasite. Its ability to concentrate in parasitized erythrocytes may account for their selective toxicity against the erythrocytic stages of plasmodial infection. As an antirheumatic, hydroxychloroquine is thought to act as a mild immunosuppressant, inhibiting the production of rheumatoid factor and acute phase reactants. It also accumulates in white blood cells, stabilizing lysosomal membranes and inhibiting the activity of many enzymes, including collagenase and the proteases that cause cartilage breakdown.
P - Antiparasitic products, insecticides and repellents > P01 - Antiprotozoals > P01B - Antimalarials > P01BA - Aminoquinolines
COVID info from Guide to PHARMACOLOGY, clinicaltrial, clinicaltrials, clinical trial, clinical trials
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C277 - Antiprotozoal Agent
D018501 - Antirheumatic Agents
D004791 - Enzyme Inhibitors
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
27 个代谢物同义名
7-Chloro-4-(4-(N-ethyl-N-beta-hydroxyethylamino)-1-methylbutylamino)quinoline; 7-Chloro-4-[4-(N-ethyl-N-beta-hydroxyethylamino)-1-methylbutylamino]quinoline; 7-Chloro-4-(4-(N-ethyl-N-β-hydroxyethylamino)-1-methylbutylamino)quinoline; 7-Chloro-4-(4-(N-ethyl-N-b-hydroxyethylamino)-1-methylbutylamino)quinoline; 7-Chloro-4-[4-(N-ethyl-N-b-hydroxyethylamino)-1-methylbutylamino]quinoline; 7-Chloro-4-[4-(N-ethyl-N-β-hydroxyethylamino)-1-methylbutylamino]quinoline; 7-Chloro-4-(4-(ethyl(2-hydroxyethyl)amino)-1-methylbutylamino)quinoline; 7-Chloro-4-[5-(N-ethyl-N-2-hydroxyethylamino)-2-pentyl]aminoquinoline; 2-({4-[(7-chloroquinolin-4-yl)amino]pentyl}(ethyl)amino)ethan-1-ol; 2-(N-(4-(7-Chlor-4-chinolylamino)-4-methylbutyl)ethylamino)ethanol; 2-((4-((7-Chloro-4-quinolyl)amino)pentyl)ethylamino)ethanol; Hydroxychloroquine sulfate (1:1) salt; Hydroxychloroquine sulfate; (+-)-Hydroxychloroquine; Hydroxychloroquinum; hydroxychloroquine; Hydroxychlorochin; Hidroxicloroquina; Oxychloroquine; Oxichloroquine; Oxichlorochine; Oxychlorochin; Polirreumin; Plaquenil; NSC4375; HCQ; Hydroxychloroquine
数据库引用编号
17 个数据库交叉引用编号
- ChEBI: CHEBI:5801
- KEGG: C07043
- KEGGdrug: D08050
- PubChem: 3652
- HMDB: HMDB0015549
- Metlin: METLIN3185
- DrugBank: DB01611
- ChEMBL: CHEMBL1535
- Wikipedia: Hydroxychloroquine
- MeSH: Hydroxychloroquine
- chemspider: 3526
- CAS: 118-42-3
- PMhub: MS000014666
- PubChem: 9255
- NIKKAJI: J5.298A
- RefMet: Hydroxychloroquine
- KNApSAcK: 5801
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Lufei Yang, Yuanyuan Liang, Jincheng Pu, Li Cai, Ronglin Gao, Fang Han, Keni Chang, Shengnan Pan, Zhenzhen Wu, Youwei Zhang, Yanqing Wang, Jiamin Song, Huihong Wu, Jianping Tang, Xuan Wang. Dysregulated serum lipid profile is associated with inflammation and disease activity in primary Sjögren's syndrome: a retrospective study in China.
Immunology letters.
2024 Jun; 267(?):106865. doi:
10.1016/j.imlet.2024.106865. [PMID: 38705483] - Ke Ding, Hailong Tian, Lei Li, Zhihan Wang, Shanshan Liu, Ning Ding, Edouard C Nice, Canhua Huang, Jinku Bao, Wei Gao, Zheng Shi. Drug repurposing-based nanoplatform via modulating autophagy to enhance chemo-phototherapy against colorectal cancer.
Journal of nanobiotechnology.
2024 Apr; 22(1):202. doi:
10.1186/s12951-024-02416-5. [PMID: 38658952] - Ji-Peng Peng, Xiao-Yu Yang, Feng Luo, Xue-Mei Yuan, Hong Xiong, Wu-Kai Ma, Xue-Ming Yao. Hydroxychloroquine-induced hyperpigmentation of the skin and bull's-eye maculopathy in rheumatic patients: a case report and literature review.
Frontiers in immunology.
2024; 15(?):1383343. doi:
10.3389/fimmu.2024.1383343. [PMID: 38660312] - Chaochao Wang, Xiaoqiao Cai, Shengfen Lin, Yongqiang Lin. Hydroxychloroquine ameliorates immune functionality and intestinal flora disorders of IgA nephropathy by inhibition of C1GALT1/Cosmc pathway.
Immunopharmacology and immunotoxicology.
2023 Dec; ?(?):1-11. doi:
10.1080/08923973.2023.2300306. [PMID: 38151955] - Feng Luo, Xue-Mei Yuan, Hong Xiong, Chang-Ming Chen, Wu-Kai Ma, Xue-Ming Yao. Acute generalized exanthematous pustulosis caused by hydroxychloroquine in a patient with rheumatoid arthritis and CARD14 mutation: Case report.
Medicine.
2023 Nov; 102(47):e36168. doi:
10.1097/md.0000000000036168. [PMID: 38013380] - Liang Ee Low, Chee Kei Kong, Wei-Hsum Yap, Sangeetaprivya P Siva, Siew Hua Gan, Wei Sheng Siew, Long Chiau Ming, Ashley Sean Lai-Foenander, Sui Kiat Chang, Wai-Leng Lee, Yongjiang Wu, Kooi-Yeong Khaw, Yong Sze Ong, Beng Ti Tey, Sachin Kumar Singh, Kamal Dua, Dinesh Kumar Chellappan, Bey-Hing Goh. Hydroxychloroquine: Key therapeutic advances and emerging nanotechnological landscape for cancer mitigation.
Chemico-biological interactions.
2023 Oct; 386(?):110750. doi:
10.1016/j.cbi.2023.110750. [PMID: 37839513] - Aiping Zhang, Shilei Chen, Riyang Lin. Combined use of total glucosides of paeony and hydroxychloroquine in primary Sjögren's syndrome: A systematic review.
Immunity, inflammation and disease.
2023 10; 11(10):e1044. doi:
10.1002/iid3.1044. [PMID: 37904705] - Narjes Morovati Moez, Seyed Mostafa Hosseini, Fereshte Kalhori, Leili Shokoohizadeh, Mohammad Reza Arabestani. Co-delivery of streptomycin and hydroxychloroquine by labeled solid lipid nanoparticles to treat brucellosis: an animal study.
Scientific reports.
2023 Aug; 13(1):14012. doi:
10.1038/s41598-023-41150-0. [PMID: 37640734] - Damien Barraud, Lonni Besançon, Elisabeth M Bik, Eric Billy, Franck Clarot, Fabrice Frank, Anthony Guihur, David Hajage, Karine Lacombe, Hervé Maisonneuve, Mathieu Molimard, Matthieu Mulot, Alexander Samuel. Why the article that led to the widespread use of hydroxychloroquine in COVID-19 should be retracted.
Therapie.
2023 Jul; 78(4):437-440. doi:
10.1016/j.therap.2023.06.001. [PMID: 37321944] - Xiaohua Yang, Maria Forstner, Christina K Rapp, Ina Rothenaigner, Yang Li, Kamyar Hadian, Matthias Griese. ABCA3 Deficiency-Variant-Specific Response to Hydroxychloroquine.
International journal of molecular sciences.
2023 May; 24(9):. doi:
10.3390/ijms24098179. [PMID: 37175887] - Kyeong-Eon Park, Soo Hee Lee, Sung Il Bae, Yeran Hwang, Seong-Ho Ok, Dawon Kang, Seung Hyun Ahn, Gyujin Sim, Jin Kyeong Park, Ju-Tae Sohn. Chloroquine inhibits vasodilation induced by ATP-sensitive potassium channels in isolated rat aorta.
General physiology and biophysics.
2023 May; 42(3):297-306. doi:
10.4149/gpb_2023008. [PMID: 37098743] - Divya Kanchibhotla, Prateek Harsora, Saumya Subramanian, M Ravi Kumar Reddy, Hari K R Venkatesh. Rate of Recovery and Symptomatic Efficacy of a Polyherbal AYUSH Formulation in the Treatment of SARS-CoV-2 Disease: A Single-arm Trial.
Alternative therapies in health and medicine.
2023 May; 29(4):134-139. doi:
". [PMID: 35951065] - Pravin Phadatare, Jayanta Debnath. Lysosomal lipid peroxidation mediates immunogenic cell death.
The Journal of clinical investigation.
2023 04; 133(8):. doi:
10.1172/jci169240. [PMID: 37066873] - Rakesh C Kukreja, Rui Wang, Saisudha Koka, Anindita Das, Arun Samidurai, Lei Xi. Treating diabetes with combination of phosphodiesterase 5 inhibitors and hydroxychloroquine-a possible prevention strategy for COVID-19?.
Molecular and cellular biochemistry.
2023 Mar; 478(3):679-696. doi:
10.1007/s11010-022-04520-2. [PMID: 36036333] - Sunipa Sarkar, Prashant Chandra Singh. Selective Action of Antimalarial Hydroxychloroquine on the Packing of Phospholipids and Interfacial Water Associated with Lysosomal Model Membranes: A Vibrational Sum Frequency Generation Study.
Langmuir : the ACS journal of surfaces and colloids.
2023 02; 39(6):2435-2443. doi:
10.1021/acs.langmuir.2c03321. [PMID: 36735290] - Ling Shuai, Jiajie She, Ruiying Diao, Huihui Zhao, Xuemin Liu, Qingyu Hu, Dongdong Li, Danna Su, Xiaofeng Ye, Yan Guo, Mei Zhong, Liping Wang. Hydroxychloroquine protects against autoimmune premature ovarian insufficiency by modulating the Treg/Th17 cell ratio in BALB/c mice.
American journal of reproductive immunology (New York, N.Y. : 1989).
2023 Feb; ?(?):e13686. doi:
10.1111/aji.13686. [PMID: 36752682] - Zahra Karimitabar, Zahra Chegini, Leili Shokoohizadeh, Narjes Morovati Moez, Mohammad Reza Arabestani, Seyed Mostafa Hosseini. Use of the quantum dot-labeled solid lipid nanoparticles for delivery of streptomycin and hydroxychloroquine: A new therapeutic approach for treatment of intracellular Brucella abortus infection.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 Feb; 158(?):114116. doi:
10.1016/j.biopha.2022.114116. [PMID: 36527846] - Zhihang Yang, Yufan Du, Lei Lei, Xue Xia, Xiaorong Wang, Fan Tong, Yuan Li, Huile Gao. Co-delivery of ibrutinib and hydroxychloroquine by albumin nanoparticles for enhanced chemotherapy of glioma.
International journal of pharmaceutics.
2023 Jan; 630(?):122436. doi:
10.1016/j.ijpharm.2022.122436. [PMID: 36436742] - Zheng-Ming Liao, Zhong-Min Zhang, Qi Liu. Hydroxychloroquine/chloroquine and the risk of acute kidney injury in COVID-19 patients: a systematic review and meta-analysis.
Renal failure.
2022 Dec; 44(1):415-425. doi:
10.1080/0886022x.2022.2046609. [PMID: 35253579] - Tiantian Cai, Jing Zhao, Yanping Yang, Yanfei Jiang, Jin-An Zhang. Hydroxychloroquine use reduces mortality risk in systemic lupus erythematosus: A systematic review and meta-analysis of cohort studies.
Lupus.
2022 Dec; 31(14):1714-1725. doi:
10.1177/09612033221129774. [PMID: 36325952] - Risa Wakiya, Kiyo Ueeda, Hiromi Shimada, Shusaku Nakashima, Tomohiro Kameda, Nobuyuki Miyatake, Mikiya Kato, Taichi Miyagi, Koichi Sugihara, Mao Mizusaki, Rina Mino, Norimitsu Kadowaki, Hiroaki Dobashi. Supplemental hydroxychloroquine therapy regulates adipokines in patients with systemic lupus erythematosus with stable disease.
Clinical rheumatology.
2022 Nov; 41(11):3345-3353. doi:
10.1007/s10067-022-06282-0. [PMID: 35849246] - Haochen Guan, Huagang Lin, Xiaojun Wang, Ying Xu, Yuqi Zheng, Xun Zhou, Xuehong Diao, Zhibin Ye, Jing Xiao. Autophagy-dependent Na+-K+-ATPase signalling and abnormal urate reabsorption in hyperuricaemia-induced renal tubular injury.
European journal of pharmacology.
2022 Oct; 932(?):175237. doi:
10.1016/j.ejphar.2022.175237. [PMID: 36063871] - Saba Ahmed, Justin Konig, Lora J Kasselman, Heather A Renna, Joshua De Leon, Steven E Carsons, Allison B Reiss. Hydroxychloroquine Effects on THP-1 Macrophage Cholesterol Handling: Cell Culture Studies Corresponding to the TARGET Cardiovascular Trial.
Medicina (Kaunas, Lithuania).
2022 Sep; 58(9):. doi:
10.3390/medicina58091287. [PMID: 36143964] - Zixuan Yuan, Mahmud Arif Pavel, Hao Wang, Jerome C Kwachukwu, Sonia Mediouni, Joseph Anthony Jablonski, Kendall W Nettles, Chakravarthy B Reddy, Susana T Valente, Scott B Hansen. Hydroxychloroquine blocks SARS-CoV-2 entry into the endocytic pathway in mammalian cell culture.
Communications biology.
2022 09; 5(1):958. doi:
10.1038/s42003-022-03841-8. [PMID: 36104427] - Kathryn R Hayden, Matthew Jones, Kyle R Elkin, Michael J Shreve, William Irvin Clees, Shirley Clark, Michael L Mashtare, Tamie L Veith, Herschel A Elliott, John E Watson, Justin Silverman, Thomas L Richard, Andrew F Read, Heather E Preisendanz. Impacts of the COVID-19 pandemic on pharmaceuticals in wastewater treated for beneficial reuse: Two case studies in central Pennsylvania.
Journal of environmental quality.
2022 Sep; 51(5):1066-1082. doi:
10.1002/jeq2.20398. [PMID: 35919971] - Fiona Perelini, Joshua Agnew, Jonathan R Skinner, Dug Yeo Han, Ross Nicholson, Nigel Wilson. Revisiting QT prolongation in acute rheumatic fever - Relevance for hydroxychloroquine treatment.
International journal of cardiology.
2022 Sep; 362(?):93-96. doi:
10.1016/j.ijcard.2022.05.053. [PMID: 35643214] - Fuxiaonan Zhao, Jianhai Wang, Qi Wang, Zhili Hou, Yingchao Zhang, Xue Li, Qi Wu, Huaiyong Chen. Organoid technology and lung injury mouse models evaluating effects of hydroxychloroquine on lung epithelial regeneration.
Experimental animals.
2022 Aug; 71(3):316-328. doi:
10.1538/expanim.21-0168. [PMID: 35197405] - Changsong Lin, Ziyu Wang, Jie Li, Xinyi Xia, Yun Liu, Qianghu Wang. Implications of SARS-CoV-2 infection for patients with rheumatic disease.
Annals of the rheumatic diseases.
2022 Aug; 81(8):e152. doi:
10.1136/annrheumdis-2020-218050. [PMID: 32792333] - Bhagteshwar Singh, Hannah Ryan, Tamara Kredo, Marty Chaplin, Tom Fletcher. Chloroquine or hydroxychloroquine for prevention and treatment of COVID-19.
Emergencias : revista de la Sociedad Espanola de Medicina de Emergencias.
2022 Aug; 34(4):305-307. doi:
NULL. [PMID: 35833770] - Pedro Santos-Moreno, Diana Buitrago-Garcia, Laura Villarreal, Anggie Aza, Michael Cabrera, Wilberto Rivero, Adriana Rojas-Villarraga. Emergency arising from patients' fear of taking antimalarials during these COVID-19 times: are antimalarials as unsafe for cardiovascular health as recent reports suggest?.
Annals of the rheumatic diseases.
2022 Aug; 81(8):e154. doi:
10.1136/annrheumdis-2020-218259. [PMID: 32647029] - Alexis Mathian, Zahir Amoura. Response to 'Impact of COVID-19 pandemic on hospitalisation of patients with systemic lupus erythematosus (SLE): report from a tertiary hospital during the peak of the pandemic' by Chuah et al.
Annals of the rheumatic diseases.
2022 Aug; 81(8):e145. doi:
10.1136/annrheumdis-2020-218487. [PMID: 32883652] - Jean W Liew, Elizabeth R Graef, Jeffrey A Sparks, Alfred Hyoungju Kim. Response to: 'Emergency arising from patients' fear of taking antimalarials during these COVID-19 times: are antimalarials as unsafe for cardiovascular health as recent reports suggest?' by Santos-Moreno et al.
Annals of the rheumatic diseases.
2022 Aug; 81(8):e155. doi:
10.1136/annrheumdis-2020-218432. [PMID: 32647030] - Pawan Kumar Doharey, Vishal Singh, Mallikarjuna Rao Gedda, Amaresh Kumar Sahoo, Pritish Kumar Varadwaj, Bechan Sharma. In silico study indicates antimalarials as direct inhibitors of SARS-CoV-2-RNA dependent RNA polymerase.
Journal of biomolecular structure & dynamics.
2022 Aug; 40(12):5588-5605. doi:
10.1080/07391102.2021.1871956. [PMID: 33475021] - Shihui Li, Rong Ma, Xin-Yue Hu, Hua-Bin Li, Wen-Chao Geng, Xianglei Kong, Chao Zhang, Dong-Sheng Guo. Drug in Drug: A Host-Guest Formulation of Azocalixarene with Hydroxychloroquine for Synergistic Anti-Inflammation.
Advanced materials (Deerfield Beach, Fla.).
2022 Aug; 34(32):e2203765. doi:
10.1002/adma.202203765. [PMID: 35680644] - Alexis Mathian, Zahir Amoura. Response to: 'Implications of SARS-CoV-2 infection for patients with rheumatic disease' by Lin et al.
Annals of the rheumatic diseases.
2022 Aug; 81(8):e153. doi:
10.1136/annrheumdis-2020-218404. [PMID: 32895236] - Lucia Račková, Erika Csekes. Redox aspects of cytotoxicity and anti-neuroinflammatory profile of chloroquine and hydroxychloroquine in serum-starved BV-2 microglia.
Toxicology and applied pharmacology.
2022 07; 447(?):116084. doi:
10.1016/j.taap.2022.116084. [PMID: 35618033] - Jonathan D Casey, Laura M Beskow, Jeremy Brown, Samuel M Brown, Étienne Gayat, Michelle Ng Gong, Michael O Harhay, Samir Jaber, Jacob C Jentzer, Pierre-François Laterre, John C Marshall, Michael A Matthay, Todd W Rice, Yves Rosenberg, Alison E Turnbull, Lorraine B Ware, Wesley H Self, Alexandre Mebazaa, Sean P Collins. Use of pragmatic and explanatory trial designs in acute care research: lessons from COVID-19.
The Lancet. Respiratory medicine.
2022 07; 10(7):700-714. doi:
10.1016/s2213-2600(22)00044-3. [PMID: 35709825] - Marcelo M Pinheiro, Gecilmara S Pileggi, Adriana M Kakehasi, Ana Paula M Gomides Reis, Edgard Torres Reis-Neto, Mirhelen M Abreu, Cleandro P Albuquerque, Nafice C Araújo, Ana Beatriz Bacchiega, Dante V Bianchi, Blanca Bica, Eloisa Bonfa, Eduardo F Borba, Danielle C S Egypto Brito, Debora C Calderaro, Ângela L B Pinto Duarte, Rafaela C Espírito Santo, Paula R Fernandes, Mariana P Guimarães, Kirla W Poti Gomes, Gabriela G Faustino Ilana, Evandro M Klumb, Claudia D L Marques, Ana Karla Guedes de Melo, Odirlei A Monticielo, Licia M H Mota, Gabriela A Munhoz, Eduardo S Paiva, Helena L Alves Pereira, José Roberto Provenza, Sandra L Euzébio Ribeiro, Laurindo F Rocha, Emilia I Sato, Telma Skare, Viviane A de Souza, Valeria Valim, Marcus V G Lacerda, Ricardo M Xavier, Gilda A Ferreira. Incidence and risk factors for moderate/severe COVID-19 in rheumatic diseases patients on hydroxychloroquine: a 24-week prospective cohort.
Clinical and experimental rheumatology.
2022 Jul; 40(7):1258-1266. doi:
10.55563/clinexprheumatol/67oyux. [PMID: 34251312] - Xiuge Gao, Xian Jing, Junqi Wang, Yuling Zheng, Yawei Qiu, Hui Ji, Lin Peng, Shanxiang Jiang, Wenda Wu, Dawei Guo. Safety considerations of chloroquine in the treatment of patients with diabetes and COVID-19.
Chemico-biological interactions.
2022 Jul; 361(?):109954. doi:
10.1016/j.cbi.2022.109954. [PMID: 35469826] - Whitney J Westhoff, Louisa H Smith, Diego F Wyszynski, Sonia Hernandez-Diaz. COVID-19 pharmacotherapy utilization patterns during pregnancy: International Registry of Coronavirus Exposure in Pregnancy.
Pharmacoepidemiology and drug safety.
2022 07; 31(7):804-809. doi:
10.1002/pds.5440. [PMID: 35426202] - Qin Shao, Liang Jin, Chengyin Li, Jing Wang, Miao Wang, Qin Wang, Bin Wu. Comparative analysis of the efficacy and safety of herbal decoction CheReCunJin alone and combined with hydroxychloroquine for treating primary Sjögren's syndrome: A randomized controlled trial.
Explore (New York, N.Y.).
2022 Jul; 18(4):416-422. doi:
10.1016/j.explore.2021.08.002. [PMID: 34417112] - Mert Oztas, Murat Bektas, Ilker Karacan, Numune Aliyeva, Ayten Dag, Sarvan Aghamuradov, Selim Berke Cevirgen, Selma Sari, Murat Bolayirli, Gunay Can, Gulen Hatemi, Emire Seyahi, Huri Ozdogan, Ahmet Gul, Serdal Ugurlu. Frequency and severity of COVID-19 in patients with various rheumatic diseases treated regularly with colchicine or hydroxychloroquine.
Journal of medical virology.
2022 07; 94(7):3431-3437. doi:
10.1002/jmv.27731. [PMID: 35315100] - Majid Ghafoori, Hassan Saadati, Mohammadreza Taghavi, Amir Azimian, Peiman Alesheikh, Mina Sadat Mohajerzadeh, Morteza Behnamfar, Marzieh Pakzad, Maryam Rameshrad. Survival of the hospitalized patients with COVID-19 receiving atorvastatin: A randomized clinical trial.
Journal of medical virology.
2022 Jul; 94(7):3160-3168. doi:
10.1002/jmv.27710. [PMID: 35274326] - Susanna Croci, Mary Anna Venneri, Stefania Mantovani, Chiara Fallerini, Elisa Benetti, Nicola Picchiotti, Federica Campolo, Francesco Imperatore, Maria Palmieri, Sergio Daga, Chiara Gabbi, Francesca Montagnani, Giada Beligni, Ticiana D J Farias, Miriam Lucia Carriero, Laura Di Sarno, Diana Alaverdian, Sigrid Aslaksen, Maria Vittoria Cubellis, Ottavia Spiga, Margherita Baldassarri, Francesca Fava, Paul J Norman, Elisa Frullanti, Andrea M Isidori, Antonio Amoroso, Francesca Mari, Simone Furini, Mario U Mondelli, Gen-Covid Multicenter Study, Mario Chiariello, Alessandra Renieri, Ilaria Meloni. The polymorphism L412F in TLR3 inhibits autophagy and is a marker of severe COVID-19 in males.
Autophagy.
2022 07; 18(7):1662-1672. doi:
10.1080/15548627.2021.1995152. [PMID: 34964709] - A Dubois, A Féral, J-B Pain, J Michot, D Fansi Ndengoue, A Benomar, E Clou, I Debrix. [Treatments for SARS-CoV-2 infection: A retrospective study of drug-drug interactions and safety].
Annales pharmaceutiques francaises.
2022 Jul; 80(4):531-542. doi:
10.1016/j.pharma.2021.11.001. [PMID: 34748737] - M Vitrone, F Mele, E Durante-Mangoni, R Zampino. Drugs and liver injury: a not to be overlooked binomial in COVID-19.
Journal of chemotherapy (Florence, Italy).
2022 Jul; 34(4):207-220. doi:
10.1080/1120009x.2021.1988203. [PMID: 34644236] - Sezin Erarpat, Süleyman Bodur, Miray Öner, Ömer Tahir Günkara, Sezgin Bakırdere. A simple and efficient derivatization strategy combined with switchable solvent liquid-liquid microextraction hydroxychloroquine methyl acetate-d3 -based quadruple isotope dilution gas chromatography mass spectrometry for the determination of hydroxychloroquine sulfate in biological fluids.
Rapid communications in mass spectrometry : RCM.
2022 Jun; 36(12):e9282. doi:
10.1002/rcm.9282. [PMID: 35229402] - Pepa Bruce, Kate Ainscough, Lee Hatter, Irene Braithwaite, Lindsay R Berry, Mark Fitzgerald, Thomas Hills, Kathy Brickell, David Cosgrave, Alex Semprini, Susan Morpeth, Scott Berry, Peter Doran, Paul Young, Richard Beasley, Alistair Nichol. Prophylaxis in healthcare workers during a pandemic: a model for a multi-centre international randomised controlled trial using Bayesian analyses.
Trials.
2022 Jun; 23(1):534. doi:
10.1186/s13063-022-06402-w. [PMID: 35761370] - Dengren Li, Kuipeng Yu, Feng Feng, Yang Zhang, Fang Bai, Yimeng Zhang, Nan Sun, Jiahui Fan, Lei Liu, Huimin Yang, Xiangdong Yang. Hydroxychloroquine alleviates renal interstitial fibrosis by inhibiting the PI3K/Akt signaling pathway.
Biochemical and biophysical research communications.
2022 06; 610(?):154-161. doi:
10.1016/j.bbrc.2022.04.058. [PMID: 35462097] - Risa Wakiya, Kiyo Ueeda, Shusaku Nakashima, Hiromi Shimada, Tomohiro Kameda, Mai Mahmoud Fahmy Mansour, Mikiya Kato, Taichi Miyagi, Koichi Sugihara, Mao Mizusaki, Rina Mino, Norimitsu Kadowaki, Hiroaki Dobashi. Effect of add-on hydroxychloroquine therapy on serum proinflammatory cytokine levels in patients with systemic lupus erythematosus.
Scientific reports.
2022 06; 12(1):10175. doi:
10.1038/s41598-022-14571-6. [PMID: 35715525] - Owen Dyer. Covid-19: Doctor who sold hydroxychloroquine as 'magic bullet' treatment is jailed.
BMJ (Clinical research ed.).
2022 06; 377(?):o1395. doi:
10.1136/bmj.o1395. [PMID: 35667680] - Bharath Kumar Tirupakuzhi Vijayaraghavan, Vivekanand Jha, Dorrilyn Rajbhandari, Sheila Nainan Myatra, Arpita Ghosh, Amritendu Bhattacharya, Sumaiya Arfin, Abhinav Bassi, Lachlan Hugh Donaldson, Naomi E Hammond, Oommen John, Rohina Joshi, Mallikarjuna Kunigari, Cynthia Amrutha, Syed Haider Mehdi Husaini, Subir Ghosh, Santosh Kumar Nag, Hari Krishnan Selvaraj, Viny Kantroo, Kamal D Shah, Balasubramanian Venkatesh. Hydroxychloroquine plus personal protective equipment versus personal protective equipment alone for the prevention of laboratory-confirmed COVID-19 infections among healthcare workers: a multicentre, parallel-group randomised controlled trial from India.
BMJ open.
2022 06; 12(6):e059540. doi:
10.1136/bmjopen-2021-059540. [PMID: 35649613] - Simona De Gregori, Francesco Falaschi, Alessia Ballesio, Alessandra Fusco, Elisa Cremonte, Roberta Canta, Umberto Sabatini, Mariadelfina Molinaro, Carlo Soffiantini, Alba Nardone, Alessandro Vicentini, Annalisa De Silvestri, Antonio Di Sabatino. Hydroxychloroquine Blood Concentrations Can Be Clinically Relevant Also After Drug Discontinuation.
Drugs in R&D.
2022 Jun; 22(2):155-163. doi:
10.1007/s40268-022-00387-2. [PMID: 35553396] - Kebai Ren, Jiao He, Yue Qiu, Zhuping Xu, Xuhui Wang, Jiaxin Li, Shuya Zang, Yiliang Yang, Jiaxin Li, Yang Long, Zhirong Zhang, Man Li, Qin He. A neutrophil-mediated carrier regulates tumor stemness by inhibiting autophagy to prevent postoperative triple-negative breast cancer recurrence and metastasis.
Acta biomaterialia.
2022 06; 145(?):185-199. doi:
10.1016/j.actbio.2022.04.017. [PMID: 35447368] - Clifford TeBay, Jeffrey R McArthur, Melissa Mangala, Nicholas Kerr, Stewart Heitmann, Matthew D Perry, Monique J Windley, Jamie I Vandenberg, Adam P Hill. Pathophysiological metabolic changes associated with disease modify the proarrhythmic risk profile of drugs with potential to prolong repolarisation.
British journal of pharmacology.
2022 06; 179(11):2631-2646. doi:
10.1111/bph.15757. [PMID: 34837219] - Mona E El Sharkasy, Manar M Tolba, Fathalla Belal, Mohamed Walash, Rasha Aboshabana. Quantitative analysis of favipiravir and hydroxychloroquine as FDA-approved drugs for treatment of COVID-19 using synchronous spectrofluorimetry: application to pharmaceutical formulations and biological fluids.
Luminescence : the journal of biological and chemical luminescence.
2022 Jun; 37(6):953-964. doi:
10.1002/bio.4240. [PMID: 35343627] - Antonia Agusti, Elena Guillen, Alfonso Ayora, Andres Anton, Cristina Aguilera, Xavier Vidal, Cristina Andres, Manuel Alonso, Meritxell Espuga, Juliana Esperalba, Mª Queralt Gorgas, Benito Almirante, Esteban Ribera. Efficacy and safety of hydroxychloroquine in healthcare professionals with mild SARS-CoV-2 infection: Prospective, non-randomized trial.
Enfermedades infecciosas y microbiologia clinica (English ed.).
2022 Jun; 40(6):289-295. doi:
10.1016/j.eimce.2020.10.015. [PMID: 35680347] - Wen Zhang, Chenman Qin, Yunyun Fei, Min Shen, Yangzhong Zhou, Yan Zhang, Xiaofeng Zeng, Shuyang Zhang. Anti-inflammatory and immune therapy in severe coronavirus disease 2019 (COVID-19) patients: An update.
Clinical immunology (Orlando, Fla.).
2022 Jun; 239(?):109022. doi:
10.1016/j.clim.2022.109022. [PMID: 35477027] - Maria F Fuentes-Gonzalez, Alberto Ordinola Navarro, Zully Carmona-Aguilera, Carlos A Hernández-Jimenez, Gustavo M Benitez-Altamirano, Luis D Beltran-Ontiveros, Cesar Lopez-Vejar, Juan P Ramirez-Hinojosa, Olga Vera-Lastra, Bruno A Lopez Luis. Outpatient prescription patterns of COVID-19 drugs in the metropolitan area of Mexico City.
Family practice.
2022 05; 39(3):515-518. doi:
10.1093/fampra/cmab167. [PMID: 34910137] - . Remdesivir and three other drugs for hospitalised patients with COVID-19: final results of the WHO Solidarity randomised trial and updated meta-analyses.
Lancet (London, England).
2022 05; 399(10339):1941-1953. doi:
10.1016/s0140-6736(22)00519-0. [PMID: 35512728] - Verónica Martín, Miguel Sanz-Novo, Iker León, Pilar Redondo, Antonio Largo, Carmen Barrientos. Computational study on the affinity of potential drugs to SARS-CoV-2 main protease.
Journal of physics. Condensed matter : an Institute of Physics journal.
2022 05; 34(29):. doi:
10.1088/1361-648x/ac6c6c. [PMID: 35504274] - Anne Caufriez, Andrés Tabernilla, Raf Van Campenhout, Axelle Cooreman, Kaat Leroy, Julen Sanz Serrano, Prashant Kadam, Bruna Dos Santos Rodrigues, Arthur Lamouroux, Steven Ballet, Mathieu Vinken. Effects of Drugs Formerly Suggested for COVID-19 Repurposing on Pannexin1 Channels.
International journal of molecular sciences.
2022 May; 23(10):. doi:
10.3390/ijms23105664. [PMID: 35628472] - Osman Moneer, Garrison Daly, Joshua J Skydel, Kate Nyhan, Peter Lurie, Joseph S Ross, Joshua D Wallach. Agreement of treatment effects from observational studies and randomized controlled trials evaluating hydroxychloroquine, lopinavir-ritonavir, or dexamethasone for covid-19: meta-epidemiological study.
BMJ (Clinical research ed.).
2022 05; 377(?):e069400. doi:
10.1136/bmj-2021-069400. [PMID: 35537738] - Mathieu E Rebeaud, Florian Cova, Valentin Ruggeri, Michaël Rochoy. Raising public awareness about the misuse of predatory journals: One year after the 'hydroxychloroquine and push-scooters accidents' hoax.
Therapie.
2022 May; 77(3):373-375. doi:
10.1016/j.therap.2021.10.009. [PMID: 34819237] - Akshay Rao, Sundar Kumar Veluswamy, Banashankari Gunjiganur Shankarappa, Rithika Manjunatha Reddy, Nethravathi Umesh, Lissy John, Lysamma Mathew, Naresh Shetty. Hydroxychloroquine as pre-exposure prophylaxis against COVID-19 infection among healthcare workers: a prospective cohort study.
Expert review of anti-infective therapy.
2022 05; 20(5):781-787. doi:
10.1080/14787210.2022.2015326. [PMID: 34865592] - Silvia Mancuso, Francesca Romana Spinelli, Luciano Agati, Maria Rosa Ciardi, Cristina Garufi, Francesco Natalucci, Emanuele Molteni, Simona Truglia, Valeria Riccieri, Roberta Priori, Claudio Maria Mastroianni, Fabrizio Conti. Hydroxychloroquine cardiotoxicity: a case-control study comparing patients with COVID-19 and patients with systemic lupus erythematosus.
Clinical and experimental rheumatology.
2022 May; 40(5):890-896. doi:
10.55563/clinexprheumatol/7ullgb. [PMID: 35383554] - Maria G Lang, Carmen Gc Vinagre, Eloisa Bonfa, Fatima R Freitas, Sandra G Pasoto, Tatiane S Brito, Luciana Pc Seguro, Raul C Maranhão, Eduardo F Borba. Hydroxychloroquine increased cholesterol transfer to high-density lipoprotein in systemic lupus erythematosus: A possible mechanism for the reversal of atherosclerosis in the disease.
Lupus.
2022 May; 31(6):659-665. doi:
10.1177/09612033221090127. [PMID: 35332823] - Ernesto Zavala-Flores, Jannin Salcedo-Matienzo, Ana Quiroz-Alva, Alfredo Berrocal-Kasay. Side effects and flares risk after SARS-CoV-2 vaccination in patients with systemic lupus erythematosus.
Clinical rheumatology.
2022 May; 41(5):1349-1357. doi:
10.1007/s10067-021-05980-5. [PMID: 34782941] - Ji-Won Kim, Sang Gyu Kwak, Hwajeong Lee, Seong-Kyu Kim, Jung-Yoon Choe, Sung-Hoon Park. Baseline use of hydroxychloroquine or immunosuppressive drugs and the risk of coronavirus disease 2019.
The Korean journal of internal medicine.
2022 05; 37(3):673-680. doi:
10.3904/kjim.2020.633. [PMID: 33706472] - Mei Nee Chiu, Maitry Bhardwaj, Sangeeta Pilkhwal Sah. Safety profile of COVID-19 drugs in a real clinical setting.
European journal of clinical pharmacology.
2022 May; 78(5):733-753. doi:
10.1007/s00228-021-03270-2. [PMID: 35088108] - Elettra Fallani, Fabio Cevenini, Pietro Enea Lazzerini, Annalisa Verdini, Simona Saponara. Off-Label Use of Hydroxychloroquine in COVID-19: Analysis of Reports of Suspected Adverse Reactions From the Italian National Network of Pharmacovigilance.
Journal of clinical pharmacology.
2022 05; 62(5):646-655. doi:
10.1002/jcph.2006. [PMID: 34802170] - Xue-Lei Fu, Yan Qian, Xiao-Hong Jin, Hai-Rong Yu, Lin Du, Hua Wu, Hong-Lin Chen, Ya-Qin Shi. COVID-19 in patients with systemic lupus erythematosus: A systematic review.
Lupus.
2022 May; 31(6):684-696. doi:
10.1177/09612033221093502. [PMID: 35382637] - Pauline Lory, Jeffrey Lombardi, Clémence Lacroix, Paola Sanchez-Pena, Serena Romani, Aurélie Grandvuillemin. Comparative study of the adverse event profile of hydroxychloroquine before and during the Sars-CoV2 pandemic.
Therapie.
2022 May; 77(3):301-307. doi:
10.1016/j.therap.2021.12.015. [PMID: 35568573] - Antonis Fanouriakis, George Bertsias, Dimitrios T Boumpas. Response to: 'Hydroxychloroquine is neutral in risk of chronic kidney disease in patients with systemic lupus erythematosus' by Wu et al.
Annals of the rheumatic diseases.
2022 05; 81(5):e76. doi:
10.1136/annrheumdis-2020-217804. [PMID: 32434817] - Chia-Ying Wu, Magdalene Tan, Jing-Yang Huang, Jeng-Yuan Chiou, James Cheng-Chung Wei. Hydroxychloroquine is neutral in risk of chronic kidney disease in patients with systemic lupus erythematosus.
Annals of the rheumatic diseases.
2022 05; 81(5):e75. doi:
10.1136/annrheumdis-2020-217728. [PMID: 32434824] - Toussaint Rouamba, Esperance Ouédraogo, Houreratou Barry, Nobila Valentin Yaméogo, Apoline Sondo, Rainatou Boly, Jacques Zoungrana, Abdoul Risgou Ouédraogo, Marc Christian Tahita, Armel Poda, Arnaud Eric Diendéré, Abdoul-Salam Ouedraogo, Innocent Valea, Isidore Traoré, Zekiba Tarnagda, Maxime K Drabo, Halidou Tinto. Assessment of Recovery Time, Worsening, and Death among Inpatients and Outpatients with COVID-19, Treated with Hydroxychloroquine or Chloroquine plus Azithromycin Combination in Burkina Faso.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.
2022 May; 118(?):224-229. doi:
10.1016/j.ijid.2022.02.034. [PMID: 35227869] - Alexander M Kaizer, Jessica Wild, Christopher J Lindsell, Todd W Rice, Wesley H Self, Samuel Brown, B Taylor Thompson, Kimberly W Hart, Clay Smith, Michael S Pulia, Nathan I Shapiro, Adit A Ginde. Trial of Early Antiviral Therapies during Non-hospitalized Outpatient Window (TREAT NOW) for COVID-19: a summary of the protocol and analysis plan for a decentralized randomized controlled trial.
Trials.
2022 Apr; 23(1):273. doi:
10.1186/s13063-022-06213-z. [PMID: 35395957] - Fabio Silvio Taccone, Maya Hites, Nicolas Dauby. From hydroxychloroquine to ivermectin: how unproven 'cures' can go viral.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.
2022 04; 28(4):472-474. doi:
10.1016/j.cmi.2022.01.008. [PMID: 35124262] - Dhaval Patel, Mohd Athar, P C Jha. Computational investigation of binding of chloroquinone and hydroxychloroquinone against PLPro of SARS-CoV-2.
Journal of biomolecular structure & dynamics.
2022 04; 40(7):3071-3081. doi:
10.1080/07391102.2020.1844804. [PMID: 33200683] - Anahita Bajka, Mario Toro, Christoph Kniestedt, Sandrine Zweifel. Decrease in Visual Acuity in a 77-Year-old Woman with Age-Related Macular Degeneration after a SARS-CoV-2 Infection Treated with Hydroxychloroquine.
Klinische Monatsblatter fur Augenheilkunde.
2022 04; 239(4):527-530. doi:
10.1055/a-1766-7035. [PMID: 35472798] - Ismail A Walbi, Hassan A Albarqi, Nayef Saleh Alghanim, Marzooq Abdullah Albadi, Hesham Mohammed Al Maimouni, Saad Ahmed Alkahtani, Ali Mohamed Alshabi, Amer S Alali, Faleh Alqahtani, Amal Hassan Al-Najjar, Mohammad A Hazzazi, Deemah S Alanazi, Abdulrahman Abdulaziz Sabei, Omer S Alsaweed, Rahaf K Alajra, Hussain Alqhtani. Effect of chronic hydroxychloroquine use on COVID-19 risk in patients with rheumatoid arthritis and systemic lupus erythematosus: a multicenter retrospective cohort.
The Journal of international medical research.
2022 Apr; 50(4):3000605221090363. doi:
10.1177/03000605221090363. [PMID: 35387504] - D Dutta, R Jindal, D Mehta, M Kumar, M Sharma. Efficacy and safety of hydroxychloroquine for managing glycemia in type-2 diabetes: A systematic review and meta-analysis.
Journal of postgraduate medicine.
2022 Apr; 68(2):85-92. doi:
10.4103/jpgm.jpgm_301_21. [PMID: 35466661] - Manaf AlQahtani, Nitya Kumar, Dhuha Aljawder, Abdulkarim Abdulrahman, Mohammed Wael Mohamed, Fatema Alnashaba, Mohammed Abu Fayyad, Faisal Alshaikh, Fatima Alsahaf, Sawsan Saeed, Amal Almahroos, Zainab Abdulrahim, Sameer Otoom, Stephen L Atkin. Randomized controlled trial of favipiravir, hydroxychloroquine, and standard care in patients with mild/moderate COVID-19 disease.
Scientific reports.
2022 03; 12(1):4925. doi:
10.1038/s41598-022-08794-w. [PMID: 35322077] - Ariel Izcovich, Reed Alexander Siemieniuk, Jessica Julia Bartoszko, Long Ge, Dena Zeraatkar, Elena Kum, Anila Qasim, Assem M Khamis, Bram Rochwerg, Thomas Agoritsas, Derek K Chu, Shelley L McLeod, Reem A Mustafa, Per Vandvik, Romina Brignardello-Petersen. Adverse effects of remdesivir, hydroxychloroquine and lopinavir/ritonavir when used for COVID-19: systematic review and meta-analysis of randomised trials.
BMJ open.
2022 03; 12(3):e048502. doi:
10.1136/bmjopen-2020-048502. [PMID: 35236729] - Marco Schiavone, Alessio Gasperetti, Elisa Gherbesi, Luca Bergamaschi, Roberto Arosio, Gianfranco Mitacchione, Maurizio Viecca, Giovanni B Forleo. Arrhythmogenic Risk and Mechanisms of QT-Prolonging Drugs to Treat COVID-19.
Cardiac electrophysiology clinics.
2022 03; 14(1):95-104. doi:
10.1016/j.ccep.2021.10.009. [PMID: 35221089] - Serena Fasano, Michele Iudici, Melania Alessia Coscia, Valentina Messiniti, Alessia Borgia, Rosella Tirri, Francesco Ciccia. Influence of hydroxychloroquine blood levels on adhesion molecules associated with endothelial dysfunction in patients with systemic lupus erythematosus.
Lupus science & medicine.
2022 03; 9(1):. doi:
10.1136/lupus-2022-000681. [PMID: 35332100] - Boukje C Eveleens Maarse, Claus Graff, Jørgen K Kanters, Michiel J van Esdonk, Michiel J B Kemme, Aliede E In 't Veld, Manon A A Jansen, Matthijs Moerland, Pim Gal. Effect of hydroxychloroquine on the cardiac ventricular repolarization: A randomized clinical trial.
British journal of clinical pharmacology.
2022 03; 88(3):1054-1062. doi:
10.1111/bcp.15013. [PMID: 34327732] - Shini Rubina S K, Anuba P A, Swetha B, Kavya Priya Kalala, Aishwarya Pm, Sarvesh Sabarathinam. Drug interaction risk between cardioprotective drugs and drugs used in treatment of COVID-19: A evidence-based review from six databases.
Diabetes & metabolic syndrome.
2022 Mar; 16(3):102451. doi:
10.1016/j.dsx.2022.102451. [PMID: 35279008] - Roger Esmel-Vilomara, Paola Dolader, Anna Sabaté-Rotes, Antoni Soriano-Arandes, Ferran Gran, Ferran Rosés-Noguer. QTc interval prolongation in patients infected with SARS-CoV-2 and treated with antiviral drugs.
Anales de pediatria.
2022 Mar; 96(3):213-220. doi:
10.1016/j.anpede.2021.04.006. [PMID: 35193834] - Ananta S Bangdiwala, David R Boulware. Technical procedures and REDCap tools for internet-based clinical trials.
Contemporary clinical trials.
2022 03; 114(?):106660. doi:
10.1016/j.cct.2021.106660. [PMID: 35085832] - Chen Tang, Ji-Cheng Lv, Su-Fang Shi, Yu-Qing Chen, Li-Jun Liu, Hong Zhang. Long-term safety and efficacy of hydroxychloroquine in patients with IgA nephropathy: a single-center experience.
Journal of nephrology.
2022 Mar; 35(2):429-440. doi:
10.1007/s40620-021-00988-1. [PMID: 33591553] - Pinky Kotecha, Alexander Light, Enrico Checcucci, Daniele Amparore, Cristian Fiori, Francesco Porpiglia, Prokar Dasgupta, Oussama Elhage. Repurposing of drugs for COVID-19: a systematic review and meta-analysis.
Panminerva medica.
2022 Mar; 64(1):96-114. doi:
10.23736/s0031-0808.20.04024-0. [PMID: 33073552] - Kabir Sardana, Sinu Rose Mathachan, Desh Deepak, Ananta Khurana, Surabhi Sinha. Cutaneous side effects of hydroxychloroquine in health care workers in a COVID referral hospital - implications for clinical practice.
The Journal of dermatological treatment.
2022 Mar; 33(2):1104-1106. doi:
10.1080/09546634.2020.1781041. [PMID: 32571115] - Deniz Demircioğlu, Nilsun Karabıyık, Emel Öztürk Durmaz, Cüyan Demirkesen, Sedef Şahin. AGEP sine pustulosis induced by hydroxychloroquine used for COVID-19 infection.
Dermatologic therapy.
2022 Mar; 35(3):e15263. doi:
10.1111/dth.15263. [PMID: 34907646] - Mohammad Albanghali, Saleh Alghamdi, Mohammed Alzahrani, Bassant Barakat, Abdul Haseeb, Jonaid Ahmad Malik, Sakeel Ahmed, Sirajudheen Anwar. Clinical Characteristics and Treatment Outcomes of Mild to Moderate COVID-19 Patients at Tertiary Care Hospital, Al Baha, Saudi Arabia: A Single Centre Study.
Journal of infection and public health.
2022 Mar; 15(3):331-337. doi:
10.1016/j.jiph.2022.02.001. [PMID: 35151012] - Maryam Khoubnasabjafari, Abolghasem Jouyban, Aida Malek Mahdavi, Leila Namvar, Kamal Esalatmanesh, Mehrzad Hajialilo, Saeed Dastgiri, Mohsen Soroush, Saeid Safiri, Alireza Khabbazi. Prevalence of COVID-19 in patients with rheumatoid arthritis (RA) already treated with hydroxychloroquine (HCQ) compared with HCQ-naive patients with RA: a multicentre cross-sectional study.
Postgraduate medical journal.
2022 03; 98(e2):e92-e93. doi:
10.1136/postgradmedj-2020-139561. [PMID: 35232849] - John E McKinnon, Dee Dee Wang, Marcus Zervos, Matt Saval, Laurie Marshall-Nightengale, Paul Kilgore, Pardeep Pabla, Ed Szandzik, Kathleen Maksimowicz-McKinnon, William W O'Neill. Safety and tolerability of hydroxychloroquine in health care workers and first responders for the prevention of COVID-19: WHIP COVID-19 Study.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.
2022 Mar; 116(?):167-173. doi:
10.1016/j.ijid.2021.12.343. [PMID: 34954095] - Priya Srihari, Alicia B Minns, Han T Gao, Allyson A Kreshak. Massive Nonfatal Hydroxychloroquine Ingestion in a Pediatric Patient.
The Journal of emergency medicine.
2022 03; 62(3):332-336. doi:
10.1016/j.jemermed.2021.10.043. [PMID: 35065861] - Tejpal Gupta, Prafulla Thakkar, Babusha Kalra, Sadhana Kannan. Hydroxychloroquine in the treatment of coronavirus disease 2019: Rapid updated systematic review and meta-analysis.
Reviews in medical virology.
2022 03; 32(2):e2276. doi:
10.1002/rmv.2276. [PMID: 34245622]
