glycocyamine (BioDeep_00000400352)
Main id: BioDeep_00000001348
natural product PANOMIX_OTCML-2023
代谢物信息卡片
2-Guanidinoacetic acid
化学式: C3H7N3O2 (117.0538242)
中文名称: 胍基乙酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(C(=O)O)N=C(N)N
InChI: InChI=1S/C3H7N3O2/c4-3(5)6-1-2(7)8/h1H2,(H,7,8)(H4,4,5,6)
描述信息
D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents > D000345 - Affinity Labels
MS2 deconvoluted using MS2Dec from all ion fragmentation data, MetaboLights identifier MTBLS1040; BPMFZUMJYQTVII-UHFFFAOYSA-N_STSL_0241_Glycocyamine_1000fmol_190403_S2_LC02MS02_057; Spectrum acquired as described in Naz et al 2017 PMID 28641411. Preparation and submission to MassBank of North America by Chaleckis R. and Tada I.
MS2 deconvoluted using CorrDec from all ion fragmentation data, MetaboLights identifier MTBLS1040; Spectrum acquired as described in Naz et al 2017 PMID 28641411. Preparation and submission to MassBank of North America by Chaleckis R. and Tada I.
同义名列表
2 个代谢物同义名
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:16344
- KEGG: C00581
- PubChem: 763
- DrugBank: DB02751
- ChEMBL: CHEMBL281593
- CAS: 352-97-6
- MoNA: MoNA016714
- MoNA: MoNA010668
- MoNA: MoNA010667
- MoNA: MoNA010666
- MoNA: MoNA010665
- MoNA: MoNA010664
- MoNA: MoNA010663
- MoNA: PT110250
- PubChem: 3860
- PDB-CCD: NMG
- 3DMET: B00139
- NIKKAJI: J4.504G
分类词条
相关代谢途径
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- J Dayan, Z Uni, F Soglia, M Zampiga, M Bordini, M Petracci, F Sirri. Dietary guanidinoacetate reduces spaghetti meat myopathy risk in the breast muscle of broiler chickens.
Animal : an international journal of animal bioscience.
2024 May; 18(5):101144. doi:
10.1016/j.animal.2024.101144. [PMID: 38642412] - Yuan Su, Xinrui Li, Jiamin Zhao, Bingzhen Ji, Xiaoyi Zhao, Jinxin Feng, Junxing Zhao. Guanidinoacetic acid ameliorates hepatic steatosis and inflammation and promotes white adipose tissue browning in middle-aged mice with high-fat-diet-induced obesity.
Food & function.
2024 Apr; 15(8):4515-4526. doi:
10.1039/d3fo05201j. [PMID: 38567805] - Douglas Janes, Blaine Suehs, Delbert M Gatlin. Dietary creatine and guanidinoacetic acid supplementation have limited effects on hybrid striped bass.
Fish physiology and biochemistry.
2023 Apr; ?(?):. doi:
10.1007/s10695-023-01196-3. [PMID: 37069332] - M Majdeddin, U Braun, A Lemme, A Golian, H Kermanshahi, S De Smet, J Michiels. Effects of feeding guanidinoacetic acid on oxidative status and creatine metabolism in broilers subjected to chronic cyclic heat stress in the finisher phase.
Poultry science.
2023 Mar; 102(6):102653. doi:
10.1016/j.psj.2023.102653. [PMID: 37030259] - Sergej M Ostojic. Cataloguing guanidinoacetic acid content in various foods.
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition.
2022 Jul; 92(3-4):158-160. doi:
10.1024/0300-9831/a000753. [PMID: 35291874] - Shiqi Zhang, Changjiang Zang, Jun Pan, Chen Ma, Caidie Wang, Xiaobin Li, Wenjie Cai, Kailun Yang. Effects of dietary guanidinoacetic acid on growth performance, guanidinoacetic acid absorption and creatine metabolism of lambs.
PloS one.
2022; 17(3):e0264864. doi:
10.1371/journal.pone.0264864. [PMID: 35275964] - Bahram Miri, Hossein Ali Ghasemi, Iman Hajkhodadadi, Amir Hossein Khaltabadi Farahani. Effects of low eggshell temperatures during incubation, in ovo feeding of L-arginine, and post-hatch dietary guanidinoacetic acid on hatching traits, performance, and physiological responses of broilers reared at low ambient temperature.
Poultry science.
2022 Jan; 101(1):101548. doi:
10.1016/j.psj.2021.101548. [PMID: 34823169] - Sergej M Ostojic. Safety of Dietary Guanidinoacetic Acid: A Villain of a Good Guy?.
Nutrients.
2021 Dec; 14(1):. doi:
10.3390/nu14010075. [PMID: 35010949] - Mehrnaz Ardalan, Matt D Miesner, Christopher D Reinhardt, Daniel U Thomson, Cheryl K Armendariz, J Scott Smith, Evan C Titgemeyer. Effects of guanidinoacetic acid supplementation on nitrogen retention and methionine flux in cattle.
Journal of animal science.
2021 Jun; 99(6):. doi:
10.1093/jas/skab172. [PMID: 34165572] - O Chandani Dinesh, Thillayampalam Kankayaliyan, Meike Rademacher, Christopher Tomlinson, Robert F Bertolo, Janet A Brunton. Neonatal Piglets Can Synthesize Adequate Creatine, but Only with Sufficient Dietary Arginine and Methionine, or with Guanidinoacetate and Excess Methionine.
The Journal of nutrition.
2021 03; 151(3):531-539. doi:
10.1093/jn/nxaa369. [PMID: 33437999] - Sophia N Verouti, Delphine Lambert, Déborah Mathis, Ganesh Pathare, Geneviève Escher, Bruno Vogt, Daniel G Fuster. Solute carrier SLC16A12 is critical for creatine and guanidinoacetate handling in the kidney.
American journal of physiology. Renal physiology.
2021 03; 320(3):F351-F358. doi:
10.1152/ajprenal.00475.2020. [PMID: 33459166] - Sergej M Ostojic, Nikola Todorovic, Valdemar Stajer. Effect of Creatine and Guanidinoacetate Supplementation on Plasma Homocysteine in Metabolically Healthy Men and Women.
Annals of nutrition & metabolism.
2021; 77(5):307-308. doi:
10.1159/000518126. [PMID: 34515059] - Dandan Jiang, Limei Duan, Qiong Jia, Jinghai Liu. Glycocyamine functionalized magnetic layered double hydroxides with multiple affinity sites for trace phosphopeptides enrichment.
Analytica chimica acta.
2020 Nov; 1136(?):25-33. doi:
10.1016/j.aca.2020.07.057. [PMID: 33081946] - Ryuta Jomura, Yu Tanno, Shin-Ichi Akanuma, Yoshiyuki Kubo, Masanori Tachikawa, Ken-Ichi Hosoya. Monocarboxylate transporter 12 as a guanidinoacetate efflux transporter in renal proximal tubular epithelial cells.
Biochimica et biophysica acta. Biomembranes.
2020 11; 1862(11):183434. doi:
10.1016/j.bbamem.2020.183434. [PMID: 32781157] - Hannah F Speer, Kimberly A Pearl, Evan C Titgemeyer. Relative bioavailability of guanidinoacetic acid delivered ruminally or abomasally to cattle.
Journal of animal science.
2020 Sep; 98(9):. doi:
10.1093/jas/skaa282. [PMID: 32845973] - M Majdeddin, U Braun, A Lemme, A Golian, H Kermanshahi, S De Smet, J Michiels. Guanidinoacetic acid supplementation improves feed conversion in broilers subjected to heat stress associated with muscle creatine loading and arginine sparing.
Poultry science.
2020 Sep; 99(9):4442-4453. doi:
10.1016/j.psj.2020.05.023. [PMID: 32867988] - Sergej M Ostojic. Human gut microbiota as a source of guanidinoacetic acid.
Medical hypotheses.
2020 Sep; 142(?):109745. doi:
10.1016/j.mehy.2020.109745. [PMID: 32344286] - Yiwen Zhang, Hang Zhou, Yong Tao, Baixue Lin. Reconstitution of the Ornithine Cycle with Arginine:Glycine Amidinotransferase to Engineer Escherichia coli into an Efficient Whole-Cell Catalyst of Guanidinoacetate.
ACS synthetic biology.
2020 08; 9(8):2066-2075. doi:
10.1021/acssynbio.0c00138. [PMID: 32702969] - A A Çenesiz, İ Yavaş, İ Çiftci, N Ceylan, H O Taşkesen. Guanidinoacetic acid supplementation is favourable to broiler diets even containing poultry by-product meal.
British poultry science.
2020 Jun; 61(3):311-319. doi:
10.1080/00071668.2020.1720909. [PMID: 32019332] - Trevor Kirby, Dana C Walters, Madalyn Brown, Erwin Jansen, Gajja S Salomons, Coleman Turgeon, Piero Rinaldo, Erland Arning, Paula Ashcraft, Teodoro Bottiglieri, Jean-Baptiste Roullet, K Michael Gibson. Post-mortem tissue analyses in a patient with succinic semialdehyde dehydrogenase deficiency (SSADHD). I. Metabolomic outcomes.
Metabolic brain disease.
2020 04; 35(4):601-614. doi:
10.1007/s11011-020-00550-1. [PMID: 32172518] - O Chandani Dinesh, Janet A Brunton, Robert F Bertolo. The Kidneys Are Quantitatively More Important than Pancreas and Gut as a Source of Guanidinoacetic Acid for Hepatic Creatine Synthesis in Sow-Reared Yucatan Miniature Piglets.
The Journal of nutrition.
2020 03; 150(3):443-449. doi:
10.1093/jn/nxz266. [PMID: 31687740] - Mehrnaz Ardalan, Erick D Batista, Evan C Titgemeyer. Effect of post-ruminal guanidinoacetic acid supplementation on creatine synthesis and plasma homocysteine concentrations in cattle.
Journal of animal science.
2020 Mar; 98(3):. doi:
10.1093/jas/skaa072. [PMID: 32152623] - Juan C Marini. Channeling of Citrulline for the Renal Synthesis of Guanidino Acetate.
The Journal of nutrition.
2020 03; 150(3):423-424. doi:
10.1093/jn/nxz310. [PMID: 31868220] - Abeer Aziza, Rania Mahmoud, Eman Zahran, Hossam Gadalla. Dietary supplementation of guanidinoacetic acid improves growth, biochemical parameters, antioxidant capacity and cytokine responses in Nile tilapia (Oreochromis niloticus).
Fish & shellfish immunology.
2020 Feb; 97(?):367-374. doi:
10.1016/j.fsi.2019.12.052. [PMID: 31866449] - Sergej M Ostojic, Laszlo Ratgeber, Andras Olah, Jozsef Betlehem, Pongras Acs. Guanidinoacetic acid deficiency: a new entity in clinical medicine?.
International journal of medical sciences.
2020; 17(16):2544-2550. doi:
10.7150/ijms.47757. [PMID: 33029096] - A Olah, V Stajer, L Ratgeber, J Betlehem, S M Ostojic. Age-Related Changes in Serum Guanidinoacetic Acid in Women.
Physiological research.
2019 12; 68(6):1033-1036. doi:
10.33549/physiolres.934189. [PMID: 31647299] - Erik Hanff, Mohammad Yusof Said, Arslan Arinc Kayacelebi, Adrian Post, Isidor Minovic, Else van den Berg, Martin H de Borst, Harry van Goor, Stephan J L Bakker, Dimitrios Tsikas. High plasma guanidinoacetate-to-homoarginine ratio is associated with high all-cause and cardiovascular mortality rate in adult renal transplant recipients.
Amino acids.
2019 Nov; 51(10-12):1485-1499. doi:
10.1007/s00726-019-02783-6. [PMID: 31535220] - L Zhang, J L Li, X F Wang, X D Zhu, F Gao, G H Zhou. Attenuating effects of guanidinoacetic acid on preslaughter transport-induced muscle energy expenditure and rapid glycolysis of broilers.
Poultry science.
2019 Aug; 98(8):3223-3232. doi:
10.3382/ps/pez052. [PMID: 30789221] - Rucheton Benoit, Mesli Samir, Julian Boutin, Amintas Samuel, Colombies Brigitte, Ducint Dominique, Redonnet-Vernhet Isabelle. LC-MS/MS measurements of urinary guanidinoacetic acid and creatine: Method optimization by deleting derivatization step.
Clinica chimica acta; international journal of clinical chemistry.
2019 Jun; 493(?):148-155. doi:
10.1016/j.cca.2019.03.007. [PMID: 30858092] - Dongting He, Libin Yang, Juntao Li, Bing Dong, Wenqing Lai, Liying Zhang. Effects of guanidinoacetic acid on growth performance, creatine metabolism and plasma amino acid profile in broilers.
Journal of animal physiology and animal nutrition.
2019 May; 103(3):766-773. doi:
10.1111/jpn.13081. [PMID: 30941826] - S S Ale Saheb Fosoul, A Azarfar, A Gheisari, H Khosravinia. Performance and physiological responses of broiler chickens to supplemental guanidinoacetic acid in arginine-deficient diets.
British poultry science.
2019 Apr; 60(2):161-168. doi:
10.1080/00071668.2018.1562156. [PMID: 30595031] - Sasa Semeredi, Valdemar Stajer, Jelena Ostojic, Milan Vranes, Sergej M Ostojic. Guanidinoacetic acid with creatine compared with creatine alone for tissue creatine content, hyperhomocysteinemia, and exercise performance: A randomized, double-blind superiority trial.
Nutrition (Burbank, Los Angeles County, Calif.).
2019 01; 57(?):162-166. doi:
10.1016/j.nut.2018.04.009. [PMID: 30170305] - Pavle Jovanov, Milan Vraneš, Marijana Sakač, Slobodan Gadžurić, Jovana Panić, Aleksandar Marić, Sergej Ostojić. Hydrophilic interaction chromatography coupled to tandem mass spectrometry as a method for simultaneous determination of guanidinoacetate and creatine.
Analytica chimica acta.
2018 Oct; 1028(?):96-103. doi:
10.1016/j.aca.2018.03.038. [PMID: 29884358] - Erik Hanff, Patricia Hafner, Alexander Bollenbach, Ulrike Bonati, Arslan Arinc Kayacelebi, Dirk Fischer, Dimitrios Tsikas. Effects of single and combined metformin and L-citrulline supplementation on L-arginine-related pathways in Becker muscular dystrophy patients: possible biochemical and clinical implications.
Amino acids.
2018 Oct; 50(10):1391-1406. doi:
10.1007/s00726-018-2614-7. [PMID: 30003335] - Jiaolong Li, Lin Zhang, Yanan Fu, Yanjiao Li, Yun Jiang, Guanghong Zhou, Feng Gao. Creatine Monohydrate and Guanidinoacetic Acid Supplementation Affects the Growth Performance, Meat Quality, and Creatine Metabolism of Finishing Pigs.
Journal of agricultural and food chemistry.
2018 Sep; 66(38):9952-9959. doi:
10.1021/acs.jafc.8b02534. [PMID: 30173511] - Zhenzhao Wang, Rui Xu, Guiping Shen, Jianghua Feng. Metabolic Response in Rabbit Urine to Occurrence and Relief of Unilateral Ureteral Obstruction.
Journal of proteome research.
2018 09; 17(9):3184-3194. doi:
10.1021/acs.jproteome.8b00304. [PMID: 30024170] - D T He, X R Gai, L B Yang, J T Li, W Q Lai, X L Sun, L Y Zhang. Effects of guanidinoacetic acid on growth performance, creatine and energy metabolism, and carcass characteristics in growing-finishing pigs.
Journal of animal science.
2018 Jul; 96(8):3264-3273. doi:
10.1093/jas/sky186. [PMID: 29741632] - Sayed Sadra Ale Saheb Fosoul, Arash Azarfar, Abbasali Gheisari, Heshmatollah Khosravinia. Energy utilisation of broiler chickens in response to guanidinoacetic acid supplementation in diets with various energy contents.
The British journal of nutrition.
2018 07; 120(2):131-140. doi:
10.1017/s0007114517003701. [PMID: 29690949] - Valdemar Stajer, Milan Vranes, Vladan Kocic, Sergej M Ostojic. Serum creatine is not a reliable marker of muscular fitness in young adults.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.
2018 Jul; 23(5):422-424. doi:
10.1080/1354750x.2018.1438514. [PMID: 29409353] - H A Córdova-Noboa, E O Oviedo-Rondón, A H Sarsour, J Barnes, D Sapcota, D López, L Gross, M Rademacher-Heilshorn, U Braun. Effect of guanidinoacetic acid supplementation on live performance, meat quality, pectoral myopathies and blood parameters of male broilers fed corn-based diets with or without poultry by-products.
Poultry science.
2018 Jul; 97(7):2494-2505. doi:
10.3382/ps/pey097. [PMID: 29669035] - Behnam Ahmadipour, Mohammadreza Sharifi, Fariborz Khajali. Pulmonary hypertensive response of broiler chickens to arginine and guanidinoacetic acid under high-altitude hypoxia.
Acta veterinaria Hungarica.
2018 03; 66(1):116-124. doi:
10.1556/004.2018.011. [PMID: 29580081] - A A DeGroot, U Braun, R N Dilger. Efficacy of guanidinoacetic acid on growth and muscle energy metabolism in broiler chicks receiving arginine-deficient diets.
Poultry science.
2018 Mar; 97(3):890-900. doi:
10.3382/ps/pex378. [PMID: 29294127] - Masanori Tachikawa, Ayane Yashiki, Shin-Ichi Akanuma, Haruka Matsukawa, Soichiro Ide, Masabumi Minami, Ken-Ichi Hosoya. Astrocytic γ-aminobutyric acid (GABA) transporters mediate guanidinoacetate transport in rat brain.
Neurochemistry international.
2018 02; 113(?):1-7. doi:
10.1016/j.neuint.2017.11.013. [PMID: 29175673] - Sergej M Ostojic, Milan Vranes, Davor Loncar, Natasa Zenic, Damir Sekulic. Guanidinoacetic Acid and Creatine are Associated with Cardiometabolic Risk Factors in Healthy Men and Women: A Cross-Sectional Study.
Nutrients.
2018 Jan; 10(1):. doi:
10.3390/nu10010087. [PMID: 29342866] - O Chandani Dinesh, Robert F Bertolo, Janet A Brunton. Creatine supplementation to total parenteral nutrition improves creatine status and supports greater liver and kidney protein synthesis in neonatal piglets.
Pediatric research.
2018 01; 83(1-1):135-141. doi:
10.1038/pr.2017.208. [PMID: 28846669] - Duygu Naile Günes, Arslan Arinc Kayacelebi, Erik Hanff, Joel Lundgren, Björn Redfors, Dimitrios Tsikas. Metabolism and distribution of pharmacological homoarginine in plasma and main organs of the anesthetized rat.
Amino acids.
2017 Dec; 49(12):2033-2044. doi:
10.1007/s00726-017-2465-7. [PMID: 28710553] - Xiaofei Yin, Helena Gibbons, Milena Rundle, Gary Frost, Breige A McNulty, Anne P Nugent, Janette Walton, Albert Flynn, Michael J Gibney, Lorraine Brennan. Estimation of Chicken Intake by Adults Using Metabolomics-Derived Markers.
The Journal of nutrition.
2017 Oct; 147(10):1850-1857. doi:
10.3945/jn.117.252197. [PMID: 28794208] - Syed Baharom, Robert De Matteo, Stacey Ellery, Paul Della Gatta, Clinton R Bruce, Greg M Kowalski, Nadia Hale, Hayley Dickinson, Richard Harding, David Walker, Rodney J Snow. Does maternal-fetal transfer of creatine occur in pregnant sheep?.
American journal of physiology. Endocrinology and metabolism.
2017 07; 313(1):E75-E83. doi:
10.1152/ajpendo.00450.2016. [PMID: 28325734] - Ramin Shahabi Tapeh, Mahdi Zhandi, Mojtaba Zaghari, Amir Akhlaghi. Effects of guanidinoacetic acid diet supplementation on semen quality and fertility of broiler breeder roosters.
Theriogenology.
2017 Feb; 89(?):178-182. doi:
10.1016/j.theriogenology.2016.11.012. [PMID: 28043349] - Sergej M Ostojic. Tackling guanidinoacetic acid for advanced cellular bioenergetics.
Nutrition (Burbank, Los Angeles County, Calif.).
2017 Feb; 34(?):55-57. doi:
10.1016/j.nut.2016.09.010. [PMID: 28063512] - Sergej M Ostojic, Jelena Ostojic, Patrik Drid, Milan Vranes, Pavle Jovanov. Dietary guanidinoacetic acid increases brain creatine levels in healthy men.
Nutrition (Burbank, Los Angeles County, Calif.).
2017 Jan; 33(?):149-156. doi:
10.1016/j.nut.2016.06.001. [PMID: 27497517] - J Tossenberger, M Rademacher, K Németh, V Halas, A Lemme. Digestibility and metabolism of dietary guanidino acetic acid fed to broilers.
Poultry science.
2016 Sep; 95(9):2058-67. doi:
10.3382/ps/pew083. [PMID: 26994189] - Mette Schmedes, Eli Kristin Aadland, Ulrik Kraemer Sundekilde, Hélène Jacques, Charles Lavigne, Ingvild Eide Graff, Øyvin Eng, Asle Holthe, Gunnar Mellgren, Jette Feveile Young, Hanne Christine Bertram, Bjørn Liaset, Morten Rahr Clausen. Lean-seafood intake decreases urinary markers of mitochondrial lipid and energy metabolism in healthy subjects: Metabolomics results from a randomized crossover intervention study.
Molecular nutrition & food research.
2016 07; 60(7):1661-72. doi:
10.1002/mnfr.201500785. [PMID: 26873789] - Nasser Dhayat, Alexandre Simonin, Manuel Anderegg, Ganesh Pathare, Benjamin P Lüscher, Christine Deisl, Giuseppe Albano, David Mordasini, Matthias A Hediger, Daniel V Surbek, Bruno Vogt, Jörn Oliver Sass, Barbara Kloeckener-Gruissem, Daniel G Fuster. Mutation in the Monocarboxylate Transporter 12 Gene Affects Guanidinoacetate Excretion but Does Not Cause Glucosuria.
Journal of the American Society of Nephrology : JASN.
2016 05; 27(5):1426-36. doi:
10.1681/asn.2015040411. [PMID: 26376857] - Martina Huemer, Daniel R Carvalho, Jaime M Brum, Özlem Ünal, Turgay Coskun, James D Weisfeld-Adams, Nina L Schrager, Sabine Scholl-Bürgi, Andrea Schlune, Markus G Donner, Martin Hersberger, Claudio Gemperle, Brunhilde Riesner, Hanno Ulmer, Johannes Häberle, Daniela Karall. Clinical phenotype, biochemical profile, and treatment in 19 patients with arginase 1 deficiency.
Journal of inherited metabolic disease.
2016 05; 39(3):331-340. doi:
10.1007/s10545-016-9928-y. [PMID: 27038030] - Lidia D Martínez, Miriam Bezard, Mabel Brunotto, Raquel Dodelson de Kremer. Creatine metabolism: detection of creatine and guanidinoacetate in saliva of healthy subjects.
Acta odontologica latinoamericana : AOL.
2016 Apr; 29(1):49-53. doi:
NULL. [PMID: 27701498] - Erik Hanff, Arslan Arinc Kayacelebi, Georgi Radoslavov Yanchev, Norbert Maassen, Arash Haghikia, Dimitrios Tsikas. Simultaneous stable-isotope dilution GC-MS measurement of homoarginine, guanidinoacetate and their common precursor arginine in plasma and their interrelationships in healthy and diseased humans.
Amino acids.
2016 Mar; 48(3):721-732. doi:
10.1007/s00726-015-2120-0. [PMID: 26573540] - Rizwan Ali Zounr, Mumammad Yar Khuhawar, Taj Muhammad Jahangir, Malik Alamgir. Improved Gas Chromatographic Determination of Guanidino Compounds Using Isovaleroylacetone and Ethyl Chloroformate as Derivatizing Reagents.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.
2016; 32(2):141-6. doi:
10.2116/analsci.32.141. [PMID: 26860556] - Sylvia Stockler-Ipsiroglu, Delia Apatean, Roberta Battini, Suzanne DeBrosse, Kimberley Dessoffy, Simon Edvardson, Florian Eichler, Katherine Johnston, David M Koeller, Sonia Nouioua, Meriem Tazir, Ashok Verma, Monica D Dowling, Klaas J Wierenga, Andrea M Wierenga, Victor Zhang, Lee-Jun C Wong. Arginine:glycine amidinotransferase (AGAT) deficiency: Clinical features and long term outcomes in 16 patients diagnosed worldwide.
Molecular genetics and metabolism.
2015 Dec; 116(4):252-9. doi:
10.1016/j.ymgme.2015.10.003. [PMID: 26490222] - Brandilyn A Peters, Megan N Hall, Xinhua Liu, Faruque Parvez, Abu B Siddique, Hasan Shahriar, Mohammad Nasir Uddin, Tariqul Islam, Vesna Ilievski, Joseph H Graziano, Mary V Gamble. Low-Dose Creatine Supplementation Lowers Plasma Guanidinoacetate, but Not Plasma Homocysteine, in a Double-Blind, Randomized, Placebo-Controlled Trial.
The Journal of nutrition.
2015 Oct; 145(10):2245-52. doi:
10.3945/jn.115.216739. [PMID: 26311810] - Stefan Pilz, Andreas Meinitzer, Martin Gaksch, Martin Grübler, Nicolas Verheyen, Christiane Drechsler, Bríain Ó Hartaigh, Florian Lang, Ioana Alesutan, Jakob Voelkl, Winfried März, Andreas Tomaschitz. Homoarginine in the renal and cardiovascular systems.
Amino acids.
2015 Sep; 47(9):1703-13. doi:
10.1007/s00726-015-1993-2. [PMID: 25929587] - Sergej M Ostojic, Marko Stojanovic. Guanidinoacetic acid loading affects plasma γ-aminobutyric acid in healthy men.
European journal of nutrition.
2015 Aug; 54(5):855-8. doi:
10.1007/s00394-015-0858-5. [PMID: 25680689] - Sergej M Ostojic, Aleksandra Vojvodic-Ostojic. Single-dose oral guanidinoacetic acid exhibits dose-dependent pharmacokinetics in healthy volunteers.
Nutrition research (New York, N.Y.).
2015 Mar; 35(3):198-205. doi:
10.1016/j.nutres.2014.12.010. [PMID: 25622538] - Sergej M Ostojic, Marko D Stojanovic, Guillermo Olcina. Oxidant-Antioxidant Capacity of Dietary Guanidinoacetic Acid.
Annals of nutrition & metabolism.
2015; 67(4):243-6. doi:
10.1159/000441198. [PMID: 26485404] - Sergej M Ostojic. An alternative mechanism for guanidinoacetic acid to affect methylation cycle.
Medical hypotheses.
2014 Dec; 83(6):847-8. doi:
10.1016/j.mehy.2014.11.001. [PMID: 25468046] - Sergej M Ostojic, Marko Stojanovic, Patrik Drid, Jay R Hoffman. Dose-response effects of oral guanidinoacetic acid on serum creatine, homocysteine and B vitamins levels.
European journal of nutrition.
2014 Dec; 53(8):1637-43. doi:
10.1007/s00394-014-0669-0. [PMID: 24535415] - Wajdi Amayreh, Uta Meyer, Anibh M Das. Treatment of arginase deficiency revisited: guanidinoacetate as a therapeutic target and biomarker for therapeutic monitoring.
Developmental medicine and child neurology.
2014 Oct; 56(10):1021-4. doi:
10.1111/dmcn.12488. [PMID: 24814679] - Christiane Auray-Blais, Bruno Maranda, Pamela Lavoie. High-throughput tandem mass spectrometry multiplex analysis for newborn urinary screening of creatine synthesis and transport disorders, Triple H syndrome and OTC deficiency.
Clinica chimica acta; international journal of clinical chemistry.
2014 Sep; 436(?):249-55. doi:
10.1016/j.cca.2014.05.024. [PMID: 24909877] - Rafael Deminice, Flávia Troncon Rosa, Gabriel Silveira Franco, Selma Freirede Carvalho da Cunha, Ellen Cristini de Freitas, Alceu Afonso Jordao. Short-term creatine supplementation does not reduce increased homocysteine concentration induced by acute exercise in humans.
European journal of nutrition.
2014 Sep; 53(6):1355-61. doi:
10.1007/s00394-013-0636-1. [PMID: 24318038] - Liqiang Gu, Xiaofan Wang, Yuanyuan Zhang, Yu Jiang, Huan Lu, Kaishun Bi, Xiaohui Chen. Determination of 12 potential nephrotoxicity biomarkers in rat serum and urine by liquid chromatography with mass spectrometry and its application to renal failure induced by Semen Strychni.
Journal of separation science.
2014 May; 37(9-10):1058-66. doi:
10.1002/jssc.201400053. [PMID: 24610835] - Dorothea Haas, Hongying Gan-Schreier, Claus-Dieter Langhans, Alexandros Anninos, Gisela Haege, Peter Burgard, Andreas Schulze, Georg F Hoffmann, Jürgen G Okun. Diagnosis and therapeutic monitoring of inborn errors of creatine metabolism and transport using liquid chromatography-tandem mass spectrometry in urine, plasma and CSF.
Gene.
2014 Mar; 538(1):188-94. doi:
10.1016/j.gene.2014.01.019. [PMID: 24440240] - Kusum K Kharbanda, Sandra L Todero, Jordan C Moats, Ryan M Harris, Natalia A Osna, Paul G Thomes, Dean J Tuma. Alcohol consumption decreases rat hepatic creatine biosynthesis via altered guanidinoacetate methyltransferase activity.
Alcoholism, clinical and experimental research.
2014 Mar; 38(3):641-8. doi:
10.1111/acer.12306. [PMID: 24256608] - Robin P da Silva, Kathy Clow, John T Brosnan, Margaret E Brosnan. Synthesis of guanidinoacetate and creatine from amino acids by rat pancreas.
The British journal of nutrition.
2014 Feb; 111(4):571-7. doi:
10.1017/s0007114513003012. [PMID: 24103317] - Yi-Qun Liu, Zheng Jia, Feng Han, Takahiro Inakuma, Tatsuya Miyashita, Kimio Sugiyama, Li-Cui Sun, Xue-Song Xiang, Zhen-Wu Huang. Suppression effects of betaine-enriched spinach on hyperhomocysteinemia induced by guanidinoacetic acid and choline deficiency in rats.
TheScientificWorldJournal.
2014; 2014(?):904501. doi:
10.1155/2014/904501. [PMID: 25250392] - Sylvia Stockler-Ipsiroglu, Clara van Karnebeek, Nicola Longo, G Christoph Korenke, Saadet Mercimek-Mahmutoglu, Iris Marquart, Bruce Barshop, Christiane Grolik, Andrea Schlune, Brad Angle, Helena Caldeira Araújo, Turgay Coskun, Luisa Diogo, Michael Geraghty, Goknur Haliloglu, Vassiliki Konstantopoulou, Vincenzo Leuzzi, Alina Levtova, Jennifer Mackenzie, Bruno Maranda, Aizeddin A Mhanni, Grant Mitchell, Andrew Morris, Theresa Newlove, Deborah Renaud, Fernando Scaglia, Vassili Valayannopoulos, Francjan J van Spronsen, Krijn T Verbruggen, Nataliya Yuskiv, William Nyhan, Andreas Schulze. Guanidinoacetate methyltransferase (GAMT) deficiency: outcomes in 48 individuals and recommendations for diagnosis, treatment and monitoring.
Molecular genetics and metabolism.
2014 Jan; 111(1):16-25. doi:
10.1016/j.ymgme.2013.10.018. [PMID: 24268530] - Takafumi Saito, Masahiro Sugimoto, Kaori Igarashi, Kaori Saito, Li Shao, Tomohiro Katsumi, Kyoko Tomita, Chikako Sato, Kazuo Okumoto, Yuko Nishise, Hisayoshi Watanabe, Masaru Tomita, Yoshiyuki Ueno, Tomoyoshi Soga. Dynamics of serum metabolites in patients with chronic hepatitis C receiving pegylated interferon plus ribavirin: a metabolomics analysis.
Metabolism: clinical and experimental.
2013 Nov; 62(11):1577-86. doi:
10.1016/j.metabol.2013.07.002. [PMID: 23953890] - Marie Joncquel-Chevalier Curt, David Cheillan, Gilbert Briand, Gajja S Salomons, Karine Mention-Mulliez, Dries Dobbelaere, Jean-Marie Cuisset, Laurence Lion-François, Vincent Des Portes, Allel Chabli, Vassili Valayannopoulos, Jean-François Benoist, Jean-Marc Pinard, Gilles Simard, Olivier Douay, Kumaran Deiva, Marc Tardieu, Alexandra Afenjar, Delphine Héron, François Rivier, Brigitte Chabrol, Fabienne Prieur, François Cartault, Gaëlle Pitelet, Alice Goldenberg, Soumeya Bekri, Marion Gerard, Richard Delorme, Nicole Porchet, Christine Vianey-Saban, Joseph Vamecq. Creatine and guanidinoacetate reference values in a French population.
Molecular genetics and metabolism.
2013 Nov; 110(3):263-7. doi:
10.1016/j.ymgme.2013.09.005. [PMID: 24090707] - Sergej M Ostojic, Barbara Niess, Marko Stojanovic, Milos Obrenovic. Co-administration of methyl donors along with guanidinoacetic acid reduces the incidence of hyperhomocysteinaemia compared with guanidinoacetic acid administration alone.
The British journal of nutrition.
2013 Sep; 110(5):865-70. doi:
10.1017/s0007114512005879. [PMID: 23351309] - S Nouioua, D Cheillan, S Zaouidi, G S Salomons, N Amedjout, F Kessaci, N Boulahdour, T Hamadouche, M Tazir. Creatine deficiency syndrome. A treatable myopathy due to arginine-glycine amidinotransferase (AGAT) deficiency.
Neuromuscular disorders : NMD.
2013 Aug; 23(8):670-4. doi:
10.1016/j.nmd.2013.04.011. [PMID: 23770102] - Laetitia Van Noolen, Denis Monneret, Véronique Ducros, Christelle Corne, Joël Lunardi, Patrice Faure. [Simultaneous determination of guanidinoacetate, creatine and creatinine by liquid chromatography-tandem mass spectrometry: a diagnostic tool for creatine deficiency syndromes in body fluids and a perspective use on cultured fibroblasts].
Annales de biologie clinique.
2013 Jul; 71(4):429-37. doi:
10.1684/abc.2013.0871. [PMID: 23906570] - Laura E McBreairty, Ross A McGowan, Janet A Brunton, Robert F Bertolo. Partitioning of [methyl-3H]methionine to methylated products and protein is altered during high methyl demand conditions in young Yucatan miniature pigs.
The Journal of nutrition.
2013 Jun; 143(6):804-9. doi:
10.3945/jn.112.172593. [PMID: 23616507] - Sergej M Ostojic, Barbara Niess, Marko Stojanovic, Milos Obrenovic. Creatine metabolism and safety profiles after six-week oral guanidinoacetic acid administration in healthy humans.
International journal of medical sciences.
2013; 10(2):141-7. doi:
10.7150/ijms.5125. [PMID: 23329885] - Sergio Lage, Fernando Andrade, José Angel Prieto, Izaskun Asla, Amaya Rodríguez, Nerea Ruiz, Juncal Echeverría, María Luz Couce, Pablo Sanjurjo, Luis Aldámiz-Echevarría. Arginine-guanidinoacetate-creatine pathway in preterm newborns: creatine biosynthesis in newborns.
Journal of pediatric endocrinology & metabolism : JPEM.
2013; 26(1-2):53-60. doi:
10.1515/jpem-2012-0293. [PMID: 23457310] - R N Dilger, K Bryant-Angeloni, R L Payne, A Lemme, C M Parsons. Dietary guanidino acetic acid is an efficacious replacement for arginine for young chicks.
Poultry science.
2013 Jan; 92(1):171-7. doi:
10.3382/ps.2012-02425. [PMID: 23243244] - David Cheillan, Marie Joncquel-Chevalier Curt, Gilbert Briand, Gajja S Salomons, Karine Mention-Mulliez, Dries Dobbelaere, Jean-Marie Cuisset, Laurence Lion-François, Vincent Des Portes, Allel Chabli, Vassili Valayannopoulos, Jean-François Benoist, Jean-Marc Pinard, Gilles Simard, Olivier Douay, Kumaran Deiva, Alexandra Afenjar, Delphine Héron, François Rivier, Brigitte Chabrol, Fabienne Prieur, François Cartault, Gaëlle Pitelet, Alice Goldenberg, Soumeya Bekri, Marion Gerard, Richard Delorme, Marc Tardieu, Nicole Porchet, Christine Vianey-Saban, Joseph Vamecq. Screening for primary creatine deficiencies in French patients with unexplained neurological symptoms.
Orphanet journal of rare diseases.
2012 Dec; 7(?):96. doi:
10.1186/1750-1172-7-96. [PMID: 23234264] - Isabel Garcia-Perez, Alma Villaseñor, Anisha Wijeyesekera, Joram M Posma, Zhirong Jiang, Jeremiah Stamler, Peter Aronson, Robert Unwin, Coral Barbas, Paul Elliott, Jeremy Nicholson, Elaine Holmes. Urinary metabolic phenotyping the slc26a6 (chloride-oxalate exchanger) null mouse model.
Journal of proteome research.
2012 Sep; 11(9):4425-35. doi:
10.1021/pr2012544. [PMID: 22594923] - Takahito Wada, Hiroko Shimbo, Hitoshi Osaka. A simple screening method using ion chromatography for the diagnosis of cerebral creatine deficiency syndromes.
Amino acids.
2012 Aug; 43(2):993-7. doi:
10.1007/s00726-011-1146-1. [PMID: 22080216] - Joseph D T Ndika, Kathreen Johnston, James A Barkovich, Michael D Wirt, Patricia O'Neill, Ofir T Betsalel, Cornelis Jakobs, Gajja S Salomons. Developmental progress and creatine restoration upon long-term creatine supplementation of a patient with arginine:glycine amidinotransferase deficiency.
Molecular genetics and metabolism.
2012 May; 106(1):48-54. doi:
10.1016/j.ymgme.2012.01.017. [PMID: 22386973] - S A Majidano, M Y Khuhawar. Gas chromatographic determination of guanidino compounds in uremic patients using glyoxal as derivatizing reagent.
Journal of chromatographic science.
2012 May; 50(5):380-6. doi:
10.1093/chromsci/bms013. [PMID: 22392369] - Olivier Levillain. Expression and function of arginine-producing and consuming-enzymes in the kidney.
Amino acids.
2012 Apr; 42(4):1237-52. doi:
10.1007/s00726-011-0897-z. [PMID: 21567240] - Zhongzan Cao, Zongxi Han, Yuhao Shao, Xiaoli Liu, Junfeng Sun, Demin Yu, Xiangang Kong, Shengwang Liu. Proteomics analysis of differentially expressed proteins in chicken trachea and kidney after infection with the highly virulent and attenuated coronavirus infectious bronchitis virus in vivo.
Proteome science.
2012 Mar; 10(?):24. doi:
10.1186/1477-5956-10-24. [PMID: 22463732] - J Michiels, L Maertens, J Buyse, A Lemme, M Rademacher, N A Dierick, S De Smet. Supplementation of guanidinoacetic acid to broiler diets: effects on performance, carcass characteristics, meat quality, and energy metabolism.
Poultry science.
2012 Feb; 91(2):402-12. doi:
10.3382/ps.2011-01585. [PMID: 22252354] - Saadet Mercimek-Mahmutoglu, Mary Dunbar, Andrea Friesen, Susan Garret, Carol Hartnett, Linda Huh, Graham Sinclair, Sylvia Stockler, Stephen Wellington, Petra J W Pouwels, Gajja S Salomons, Cornelis Jakobs. Evaluation of two year treatment outcome and limited impact of arginine restriction in a patient with GAMT deficiency.
Molecular genetics and metabolism.
2012 Jan; 105(1):155-8. doi:
10.1016/j.ymgme.2011.09.037. [PMID: 22019491] - Fahmi Nasrallah, Ichraf Kraoua, Marie Joncquel-Chevalier Curt, Marie-Adelaïde Bout, Sameh Hadj Taieb, Moncef Feki, Néziha Khouja, Gilbert Briand, Naziha Kaabachi. Guanidinoacetate methyltransferase (GAMT) deficiency in two Tunisian siblings: clinical and biochemical features.
Clinical laboratory.
2012; 58(5-6):427-32. doi:
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PloS one.
2012; 7(2):e32557. doi:
10.1371/journal.pone.0032557. [PMID: 22384273] - Aaron Kaplan, Moshe Harel, Ruth N Kaplan-Levy, Ora Hadas, Assaf Sukenik, Elke Dittmann. The languages spoken in the water body (or the biological role of cyanobacterial toxins).
Frontiers in microbiology.
2012; 3(?):138. doi:
10.3389/fmicb.2012.00138. [PMID: 22529842] - Sara Boenzi, Cristiano Rizzo, Vincenzo Maria Di Ciommo, Diego Martinelli, Bianca Maria Goffredo, Giancarlo la Marca, Carlo Dionisi-Vici. Simultaneous determination of creatine and guanidinoacetate in plasma by liquid chromatography-tandem mass spectrometry (LC-MS/MS).
Journal of pharmaceutical and biomedical analysis.
2011 Dec; 56(4):792-8. doi:
10.1016/j.jpba.2011.06.006. [PMID: 21742455] - Rafael Deminice, Robin P da Silva, Simon G Lamarre, Colin Brown, George N Furey, Shannon A McCarter, Alceu Afonso Jordao, Karen B Kelly, Kirst King-Jones, René L Jacobs, Margaret E Brosnan, John T Brosnan. Creatine supplementation prevents the accumulation of fat in the livers of rats fed a high-fat diet.
The Journal of nutrition.
2011 Oct; 141(10):1799-804. doi:
10.3945/jn.111.144857. [PMID: 21880953] - Maria Antonietta Mencarelli, Maria Tassini, Marzia Pollazzon, Antonio Vivi, Marco Calderisi, Michele Falco, Marco Fichera, Lucia Monti, Sabrina Buoni, Francesca Mari, Udo Engelke, Ron A Wevers, Joussef Hayek, Alessandra Renieri. Creatine transporter defect diagnosed by proton NMR spectroscopy in males with intellectual disability.
American journal of medical genetics. Part A.
2011 Oct; 155A(10):2446-52. doi:
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