Cytidine (BioDeep_00000398587)

Main id: BioDeep_00000000364

 

natural product PANOMIX_OTCML-2023


代谢物信息卡片


Cytidine,cell culture tested

化学式: C9H13N3O5 (243.0855168)
中文名称: 胞嘧啶核苷
谱图信息: 最多检出来源 Homo sapiens(blood) 0.09%

分子结构信息

SMILES: C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)O
InChI: InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)

描述信息

MS2 deconvoluted using MS2Dec from all ion fragmentation data, MetaboLights identifier MTBLS1040; UHDGCWIWMRVCDJ_STSL_0155_Cytidine_8000fmol_180506_S2_LC02_MS02_107; Spectrum acquired as described in Naz et al 2017 PMID 28641411. Preparation and submission to MassBank of North America by Chaleckis R. and Tada I.
MS2 deconvoluted using CorrDec from all ion fragmentation data, MetaboLights identifier MTBLS1040; Spectrum acquired as described in Naz et al 2017 PMID 28641411. Preparation and submission to MassBank of North America by Chaleckis R. and Tada I.
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.054
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.051
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.053
Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function[1][2][3].
Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function[1][2][3].
Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function[1][2][3].

同义名列表

5 个代谢物同义名

Cytidine; Cytidine,cell culture tested; Cyd; Cytosine β-D-riboside; Cytosine-1-β-D-ribofuranoside



数据库引用编号

70 个数据库交叉引用编号

分类词条

27 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Bei Zheng, Qinqin Zhao, Wenjuan Yang, Pinpin Feng, Chuanwei Xin, Yin Ying, Bo Yang, Bing Han, Jun Zhu, Meiling Zhang, Gonghua Li. Small-molecule antiviral treatments for COVID-19: A systematic review and network meta-analysis. International journal of antimicrobial agents. 2024 Mar; 63(3):107096. doi: 10.1016/j.ijantimicag.2024.107096. [PMID: 38244811]
  • Nagi M El-Shafai, Yasser S Mostafa, Mohamed S Ramadan, Ibrahim M El-Mehasseb. Enhancement efficiency delivery of antiviral Molnupiravir-drug via the loading with self-assembly nanoparticles of pycnogenol and cellulose which are decorated by zinc oxide nanoparticles for COVID-19 therapy. Bioorganic chemistry. 2024 Feb; 143(?):107028. doi: 10.1016/j.bioorg.2023.107028. [PMID: 38086240]
  • Elena Lesch, Maike Simone Stempel, Vanessa Dressnandt, Bastian Oldenkott, Volker Knoop, Mareike Schallenberg-Rüdinger. Conservation of the moss RNA editing factor PPR78 despite the loss of its known C-to-U editing sites is explained by a hidden extra target. The Plant cell. 2023 Nov; ?(?):. doi: 10.1093/plcell/koad292. [PMID: 38000897]
  • Chen Wang, Guangming Ma, Shanqi Zhang, Kunhong Zhao, Xiangyang Li. Study on the binding of ningnanmycin to the helicase of Tobamovirus virus. Pesticide biochemistry and physiology. 2023 Aug; 194(?):105494. doi: 10.1016/j.pestbp.2023.105494. [PMID: 37532353]
  • Wenlei Wang, Huijie Liu, Feifei Wang, Xiaoye Liu, Yu Sun, Jie Zhao, Changhua Zhu, Lijun Gan, Jinping Yu, Claus-Peter Witte, Mingjia Chen. N4-acetylation of cytidine in (m)RNA plays essential roles in plants. The Plant cell. 2023 Jun; ?(?):. doi: 10.1093/plcell/koad189. [PMID: 37367221]
  • Bin Li, Donghao Li, Linjun Cai, Qiting Zhou, Cong Liu, Jianzhong Lin, Yixing Li, Xiaoying Zhao, Li Li, Xuanming Liu, Chongsheng He. Transcriptome-wide profiling of RNA N4-cytidine acetylation in Arabidopsis thaliana and Oryza sativa. Molecular plant. 2023 06; 16(6):1082-1098. doi: 10.1016/j.molp.2023.04.009. [PMID: 37073130]
  • Kaixia Niu, Pengpeng Bai, Junyang Zhang, Xinchi Feng, Feng Qiu. Cytidine Alleviates Dyslipidemia and Modulates the Gut Microbiota Composition in ob/ob Mice. Nutrients. 2023 Feb; 15(5):. doi: 10.3390/nu15051147. [PMID: 36904146]
  • Wen Wen, Chen Chen, Jiake Tang, Chunyi Wang, Mengyun Zhou, Yongran Cheng, Xiang Zhou, Qi Wu, Xingwei Zhang, Zhanhui Feng, Mingwei Wang, Qin Mao. Efficacy and safety of three new oral antiviral treatment (molnupiravir, fluvoxamine and Paxlovid) for COVID-19：a meta-analysis. Annals of medicine. 2022 12; 54(1):516-523. doi: 10.1080/07853890.2022.2034936. [PMID: 35118917]
  • Muhammad Jawad Akbar Awan, Komal Pervaiz, Awais Rasheed, Imran Amin, Nasir A Saeed, Kanwarpal S Dhugga, Shahid Mansoor. Genome edited wheat- current advances for the second green revolution. Biotechnology advances. 2022 11; 60(?):108006. doi: 10.1016/j.biotechadv.2022.108006. [PMID: 35732256]
  • Husheem Michael, Vishal Srivastava, Loic Deblais, Joshua O Amimo, Juliet Chepngeno, Linda J Saif, Gireesh Rajashekara, Anastasia N Vlasova. The Combined Escherichia coli Nissle 1917 and Tryptophan Treatment Modulates Immune and Metabolome Responses to Human Rotavirus Infection in a Human Infant Fecal Microbiota-Transplanted Malnourished Gnotobiotic Pig Model. mSphere. 2022 Oct; 7(5):e0027022. doi: 10.1128/msphere.00270-22. [PMID: 36073800]
  • Elena Lesch, Maximilian T Schilling, Sarah Brenner, Yingying Yang, Oliver J Gruss, Volker Knoop, Mareike Schallenberg-Rüdinger. Plant mitochondrial RNA editing factors can perform targeted C-to-U editing of nuclear transcripts in human cells. Nucleic acids research. 2022 09; 50(17):9966-9983. doi: 10.1093/nar/gkac752. [PMID: 36107771]
  • Mizuho Ichinose, Masuyo Kawabata, Yumi Akaiwa, Yasuka Shimajiri, Izumi Nakamura, Takayuki Tamai, Takahiro Nakamura, Yusuke Yagi, Bernard Gutmann. U-to-C RNA editing by synthetic PPR-DYW proteins in bacteria and human culture cells. Communications biology. 2022 09; 5(1):968. doi: 10.1038/s42003-022-03927-3. [PMID: 36109586]
  • Mahmood Hassan Dalhat, Mohammed Razeeth Shait Mohammed, Hind Ali Alkhatabi, Mohd Rehan, Aamir Ahmad, Hani Choudhry, Mohammad Imran Khan. NAT10: An RNA cytidine transferase regulates fatty acid metabolism in cancer cells. Clinical and translational medicine. 2022 09; 12(9):e1045. doi: 10.1002/ctm2.1045. [PMID: 36149760]
  • Pal Maliga. Engineering the plastid and mitochondrial genomes of flowering plants. Nature plants. 2022 09; 8(9):996-1006. doi: 10.1038/s41477-022-01227-6. [PMID: 36038655]
  • Ayako Maeda, Sachi Takenaka, Tenghua Wang, Brody Frink, Toshiharu Shikanai, Mizuki Takenaka. DYW deaminase domain has a distinct preference for neighboring nucleotides of the target RNA editing sites. The Plant journal : for cell and molecular biology. 2022 08; 111(3):756-767. doi: 10.1111/tpj.15850. [PMID: 35652245]
  • Junhua Kong, Virginie Garcia, Enric Zehraoui, Linda Stammitti, Ghislaine Hilbert, Christel Renaud, Stéphane Maury, Alain Delaunay, Stéphanie Cluzet, Fatma Lecourieux, David Lecourieux, Emeline Teyssier, Philippe Gallusci. Zebularine, a DNA Methylation Inhibitor, Activates Anthocyanin Accumulation in Grapevine Cells. Genes. 2022 07; 13(7):. doi: 10.3390/genes13071256. [PMID: 35886036]
  • Kyle Rosenke, Atsushi Okumura, Matthew C Lewis, Friederike Feldmann, Kimberly Meade-White, W Forrest Bohler, Amanda Griffin, Rebecca Rosenke, Carl Shaia, Michael A Jarvis, Heinz Feldmann. Molnupiravir inhibits SARS-CoV-2 variants including Omicron in the hamster model. JCI insight. 2022 Jul; 7(13):. doi: 10.1172/jci.insight.160108. [PMID: 35579953]
  • Hardik Goswami, Adnan Alsumali, Yiling Jiang, Matthias Schindler, Elizabeth R Duke, Joshua Cohen, Andrew Briggs, Amy Puenpatom. Cost-Effectiveness Analysis of Molnupiravir Versus Best Supportive Care for the Treatment of Outpatient COVID-19 in Adults in the US. PharmacoEconomics. 2022 Jul; 40(7):699-714. doi: 10.1007/s40273-022-01168-0. [PMID: 35779197]
  • Prajakta Kulkarni, Sriram Padmanabhan. A novel property of hexokinase inhibition by Favipiravir and proposed advantages over Molnupiravir and 2 Deoxy D glucose in treating COVID-19. Biotechnology letters. 2022 Jul; 44(7):831-843. doi: 10.1007/s10529-022-03259-6. [PMID: 35608787]
  • Ryuta Uraki, Maki Kiso, Shun Iida, Masaki Imai, Emi Takashita, Makoto Kuroda, Peter J Halfmann, Samantha Loeber, Tadashi Maemura, Seiya Yamayoshi, Seiichiro Fujisaki, Zhongde Wang, Mutsumi Ito, Michiko Ujie, Kiyoko Iwatsuki-Horimoto, Yuri Furusawa, Ryan Wright, Zhenlu Chong, Seiya Ozono, Atsuhiro Yasuhara, Hiroshi Ueki, Yuko Sakai-Tagawa, Rong Li, Yanan Liu, Deanna Larson, Michiko Koga, Takeya Tsutsumi, Eisuke Adachi, Makoto Saito, Shinya Yamamoto, Masao Hagihara, Keiko Mitamura, Tetsuro Sato, Masayuki Hojo, Shin-Ichiro Hattori, Kenji Maeda, Riccardo Valdez, Moe Okuda, Jurika Murakami, Calvin Duong, Sucheta Godbole, Daniel C Douek, Ken Maeda, Shinji Watanabe, Aubree Gordon, Norio Ohmagari, Hiroshi Yotsuyanagi, Michael S Diamond, Hideki Hasegawa, Hiroaki Mitsuya, Tadaki Suzuki, Yoshihiro Kawaoka. Characterization and antiviral susceptibility of SARS-CoV-2 Omicron BA.2. Nature. 2022 07; 607(7917):119-127. doi: 10.1038/s41586-022-04856-1. [PMID: 35576972]
  • Sri Masyeni, Muhammad Iqhrammullah, Andri Frediansyah, Firzan Nainu, Trina Tallei, Talha Bin Emran, Youdiil Ophinni, Kuldeep Dhama, Harapan Harapan. Molnupiravir: A lethal mutagenic drug against rapidly mutating severe acute respiratory syndrome coronavirus 2-A narrative review. Journal of medical virology. 2022 Jul; 94(7):3006-3016. doi: 10.1002/jmv.27730. [PMID: 35315098]
  • Ashley Jia Wen Yip, Zheng Yao Low, Vincent T K Chow, Sunil K Lal. Repurposing Molnupiravir for COVID-19: The Mechanisms of Antiviral Activity. Viruses. 2022 06; 14(6):. doi: 10.3390/v14061345. [PMID: 35746815]
  • Hulda R Jonsdottir, Denise Siegrist, Thomas Julien, Blandine Padey, Mendy Bouveret, Olivier Terrier, Andres Pizzorno, Song Huang, Kirandeep Samby, Timothy N C Wells, Bernadett Boda, Manuel Rosa-Calatrava, Olivier B Engler, Samuel Constant. Molnupiravir combined with different repurposed drugs further inhibits SARS-CoV-2 infection in human nasal epithelium in vitro. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Jun; 150(?):113058. doi: 10.1016/j.biopha.2022.113058. [PMID: 35658229]
  • Anmar Al-Taie, Fatma Rana Denkdemir, Zaineb Sharief, Ayse Seyma Buyuk, Semra Şardaş. The Long View on COVID-19 Theranostics and Oral Antivirals: Living with Endemic Disease and Lessons from Molnupiravir. Omics : a journal of integrative biology. 2022 Jun; 26(6):324-328. doi: 10.1089/omi.2022.0045. [PMID: 35580151]
  • Fatima Kayali, Marco Shiu Tsun Leung, Wilson Wong, Kara Pittendrigh Morgan, Amer Harky. What impact can molnupiravir have on the treatment of SARS-CoV-2 infection?. Expert opinion on pharmacotherapy. 2022 06; 23(8):865-868. doi: 10.1080/14656566.2022.2057795. [PMID: 35341442]
  • Tuba Reçber, Selin Seda Timur, Sevilay Erdoğan Kablan, Fatma Yalçın, Tutku Ceren Karabulut, R Neslihan Gürsoy, Hakan Eroğlu, Sedef Kır, Emirhan Nemutlu. A stability indicating RP-HPLC method for determination of the COVID-19 drug molnupiravir applied using nanoformulations in permeability studies. Journal of pharmaceutical and biomedical analysis. 2022 May; 214(?):114693. doi: 10.1016/j.jpba.2022.114693. [PMID: 35276385]
  • Wendong Jia, Chengzhen Hu, Yuqin Wang, Panke Zhang, Hong-Yuan Chen, Shuo Huang. A Nanopore Based Molnupiravir Sensor. ACS sensors. 2022 05; 7(5):1564-1571. doi: 10.1021/acssensors.2c00447. [PMID: 35427117]
  • Yuexiang Li, Miaomiao Liu, Yunzheng Yan, Zhuang Wang, Qingsong Dai, Xiaotong Yang, Xiaojia Guo, Wei Li, Xingjuan Chen, Ruiyuan Cao, Wu Zhong. Molnupiravir and Its Active Form, EIDD-1931, Show Potent Antiviral Activity against Enterovirus Infections In Vitro and In Vivo. Viruses. 2022 05; 14(6):. doi: 10.3390/v14061142. [PMID: 35746614]
  • K B Wallace, J A Bjork. Molnupiravir; molecular and functional descriptors of mitochondrial safety. Toxicology and applied pharmacology. 2022 05; 442(?):116003. doi: 10.1016/j.taap.2022.116003. [PMID: 35358570]
  • Andy Extance. Covid-19: What is the evidence for the antiviral molnupiravir?. BMJ (Clinical research ed.). 2022 04; 377(?):o926. doi: 10.1136/bmj.o926. [PMID: 35418477]
  • Yuan Bai, Mingwang Shen, Lei Zhang. Antiviral Efficacy of Molnupiravir for COVID-19 Treatment. Viruses. 2022 04; 14(4):. doi: 10.3390/v14040763. [PMID: 35458493]
  • Yasmine Ahmed Sharaf, Sami El Deeb, Adel Ehab Ibrahim, Ahmed Al-Harrasi, Rania Adel Sayed. Two Green Micellar HPLC and Mathematically Assisted UV Spectroscopic Methods for the Simultaneous Determination of Molnupiravir and Favipiravir as a Novel Combined COVID-19 Antiviral Regimen. Molecules (Basel, Switzerland). 2022 Apr; 27(7):. doi: 10.3390/molecules27072330. [PMID: 35408729]
  • David C Schultz, Robert M Johnson, Kasirajan Ayyanathan, Jesse Miller, Kanupriya Whig, Brinda Kamalia, Mark Dittmar, Stuart Weston, Holly L Hammond, Carly Dillen, Jeremy Ardanuy, Louis Taylor, Jae Seung Lee, Minghua Li, Emily Lee, Clarissa Shoffler, Christopher Petucci, Samuel Constant, Marc Ferrer, Christoph A Thaiss, Matthew B Frieman, Sara Cherry. Pyrimidine inhibitors synergize with nucleoside analogues to block SARS-CoV-2. Nature. 2022 04; 604(7904):134-140. doi: 10.1038/s41586-022-04482-x. [PMID: 35130559]
  • Henry S Sacks. In nonhospitalized, unvaccinated adults with COVID-19, molnupiravir reduced hospitalization or death at 29 d. Annals of internal medicine. 2022 04; 175(4):JC40. doi: 10.7326/j22-0017. [PMID: 35377719]
  • Ismail Celik, Trina E Tallei. A computational comparative analysis of the binding mechanism of molnupiravir's active metabolite to RNA-dependent RNA polymerase of wild-type and Delta subvariant AY.4 of SARS-CoV-2. Journal of cellular biochemistry. 2022 04; 123(4):807-818. doi: 10.1002/jcb.30226. [PMID: 35132671]
  • Dominique Roberfroid, Vicky Jespers, Frank Hulstaert. Molnupiravir for Covid-19 in Nonhospitalized Patients. The New England journal of medicine. 2022 03; 386(13):e32. doi: 10.1056/nejmc2201612. [PMID: 35294807]
  • Carisa De Anda, Matthew G Johnson, Alison Pedley. Molnupiravir for Covid-19 in Nonhospitalized Patients. Reply. The New England journal of medicine. 2022 03; 386(13):e32. doi: 10.1056/nejmc2201612. [PMID: 35294808]
  • Pablo Selvi-Sabater, Juan Abellon-Ruiz. Molnupiravir for Covid-19 in Nonhospitalized Patients. The New England journal of medicine. 2022 03; 386(13):e32. doi: 10.1056/nejmc2201612. [PMID: 35294805]
  • Kristian Thorlund, Kyle Sheldrick, Edward Mills. Molnupiravir for Covid-19 in Nonhospitalized Patients. The New England journal of medicine. 2022 03; 386(13):e32. doi: 10.1056/nejmc2201612. [PMID: 35294804]
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  • Ravi Mehta, Elena Chekmeneva, Heather Jackson, Caroline Sands, Ewurabena Mills, Dominique Arancon, Ho Kwong Li, Paul Arkell, Timothy M Rawson, Robert Hammond, Maisarah Amran, Anna Haber, Graham S Cooke, Mahdad Noursadeghi, Myrsini Kaforou, Matthew R Lewis, Zoltan Takats, Shiranee Sriskandan. Antiviral metabolite 3'-deoxy-3',4'-didehydro-cytidine is detectable in serum and identifies acute viral infections including COVID-19. Med (New York, N.Y.). 2022 Mar; 3(3):204-215.e6. doi: 10.1016/j.medj.2022.01.009. [PMID: 35128501]
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