Puerarin (BioDeep_00000398478)
Main id: BioDeep_00000002636
natural product PANOMIX_OTCML-2023
代谢物信息卡片
7-hydroxy-3-(4-hydroxyphenyl)-8-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-tetrahydropyranyl]-4-chromenone
化学式: C21H20O9 (416.110727)
中文名称: 葛根素
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC(=CC=C1C2=COC3=C(C2=O)C=CC(=C3C4C(C(C(C(O4)CO)O)O)O)O)O
InChI: InChI=1S/C21H20O9/c22-7-14-17(26)18(27)19(28)21(30-14)15-13(24)6-5-11-16(25)12(8-29-20(11)15)9-1-3-10(23)4-2-9/h1-6,8,14,17-19,21-24,26-28H,7H2
描述信息
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
Puerarin, an isoflavone extracted from Radix puerariae, is a 5-HT2C receptor antagonist.
Puerarin, an isoflavone extracted from Radix puerariae, is a 5-HT2C receptor antagonist.
Puerarin, an isoflavone extracted from Radix puerariae, is a 5-HT2C receptor antagonist.
同义名列表
13 个代谢物同义名
7-Hydroxy-3-(4-hydroxyphenyl)-8-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]chromen-4-one; Puerarin; 7-hydroxy-3-(4-hydroxyphenyl)-8-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-tetrahydropyranyl]-4-chromenone; 7-hydroxy-3-(4-hydroxyphenyl)-8-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]chromen-4-one; 7-hydroxy-3-(4-hydroxyphenyl)-8-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]chromen-4-one; 7-hydroxy-3-(4-hydroxyphenyl)-8-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-methylol-tetrahydropyran-2-yl]chromone; 8-(beta-D-Glucopyranosyl-7-hydroxy-3- (4-hydroxyphenyl)-4H-1-benzopyran-4-one; 82435_FLUKA; P5555_SIGMA; 3681-99-0; NPI-31G; C10524; 8-Glucosyldaidzein
数据库引用编号
22 个数据库交叉引用编号
- ChEBI: CHEBI:182286
- ChEBI: CHEBI:8633
- PubChem: 5385074
- PubChem: 5281807
- PubChem: 5538727 CID:5571772 CID:6915832 CID:15068212 CID:5281807 CID:5486172 CID:5385074
- DrugBank: DB12290
- ChEMBL: CHEMBL1319403
- ChEMBL: CHEMBL486386
- CAS: 3681-99-0
- MoNA: MetaboBASE0338
- MoNA: MetaboBASE0337
- MoNA: MetaboBASE0336
- MoNA: MetaboBASE0335
- MoNA: MetaboBASE0334
- MoNA: MetaboBASE0333
- MoNA: PT204300
- MoNA: PT104300
- MoNA: TY000117
- MoNA: TY000039
- MoNA: TY000030
- RefMet: Puerarin
- medchemexpress: HY-N0145
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
36 个相关的物种来源信息
- 33090 川牛膝: -
- 33090 萱草根: -
- 33090 葛根: -
- 33090 柴胡: -
- 33090 葛花: -
- 52451 Bupleurum chinense: 10.1016/J.BSE.2007.03.023
- 3893 Pueraria montana var. lobata:
- 861244 Pueraria candollei var. mirifica:
- 326968 Ziziphus jujuba: 10.1016/S0040-4020(00)00842-5
- 1770154 Sorbus cuspidata: 10.1016/J.PHYTOCHEM.2010.08.015
- 174171 Clematis hexapetala: 10.1515/ZNB-2007-0615
- 457826 Pueraria tuberosa: 10.1016/S0021-9673(01)95520-7
- 3892 Pueraria:
- 1888384 Pueraria edulis: 10.1016/J.JCHROMB.2014.12.014
- 109224 Neustanthus phaseoloides: 10.1016/J.JCHROMB.2014.12.014
- 1888383 Pueraria calycina: 10.1016/J.JCHROMB.2014.12.014
- 714492 Toxicopueraria peduncularis: 10.1016/J.JCHROMB.2014.12.014
- 3803 Fabaceae: 10.1016/J.TAAP.2009.12.023
- 174648 Pueraria montana var. thomsonii:
- 691243 Thomsonaria thomsonii: 10.1016/J.PHYTOCHEM.2010.08.015
- 52451 Bupleurum chinense: 10.1016/J.BSE.2007.03.023
- 3893 Pueraria montana var. lobata:
- 861244 Pueraria candollei var. mirifica:
- 326968 Ziziphus jujuba: 10.1016/S0040-4020(00)00842-5
- 1770154 Sorbus cuspidata: 10.1016/J.PHYTOCHEM.2010.08.015
- 174171 Clematis hexapetala: 10.1515/ZNB-2007-0615
- 457826 Pueraria tuberosa: 10.1016/S0021-9673(01)95520-7
- 3892 Pueraria:
- 1888384 Pueraria edulis: 10.1016/J.JCHROMB.2014.12.014
- 109224 Neustanthus phaseoloides: 10.1016/J.JCHROMB.2014.12.014
- 1888383 Pueraria calycina: 10.1016/J.JCHROMB.2014.12.014
- 714492 Toxicopueraria peduncularis: 10.1016/J.JCHROMB.2014.12.014
- 3803 Fabaceae: 10.1016/J.TAAP.2009.12.023
- 174648 Pueraria montana var. thomsonii:
- 691243 Thomsonaria thomsonii: 10.1016/J.PHYTOCHEM.2010.08.015
- 33090 Plants: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yingying Lai, Ningning Yang, Donghao Shi, Xianhui Ma, Yingying Huang, Jingzhou Lu, Xuzi Zhang, Hui Zhou, Weiyang Gao, Cong Mao, Long Wang. Puerarin enhances TFEB-mediated autophagy and attenuates ROS-induced pyroptosis after ischemic injury of random-pattern skin flaps.
European journal of pharmacology.
2024 Jul; 974(?):176621. doi:
10.1016/j.ejphar.2024.176621. [PMID: 38679118] - Qing Tao, Yu Chen, Qiao Liang, Jianfeng Shi, Zhiguo Wang, Haiyan Min, Qian Gao, Xiaoming Yao, Lei Wang. Puerarin Alleviates Experimental Autoimmune Thyroiditis by Regulating Macrophages.
Journal of immunology (Baltimore, Md. : 1950).
2024 Jun; 212(11):1670-1679. doi:
10.4049/jimmunol.2300779. [PMID: 38668725] - Tian-Ci Zhang, Yi-Can Lin, Ning-Ning Sun, Shan Liu, Wen-Zhu Hu, Yan Zhao, Xian-Hui Dong, Xiao-Ping He. Icariin, astragaloside a and puerarin mixture attenuates cognitive impairment in APP/PS1 mice via inhibition of ferroptosis-lipid peroxidation.
Neurochemistry international.
2024 May; 175(?):105705. doi:
10.1016/j.neuint.2024.105705. [PMID: 38412923] - Huizhen Wei, Mengru Sun, Ruixuan Wang, Hairong Zeng, Bei Zhao, Shenyi Jin. Puerarin mitigated LPS-ATP or HG-primed endothelial cells damage and diabetes-associated cardiovascular disease via ROS-NLRP3 signalling.
Journal of cellular and molecular medicine.
2024 May; 28(10):e18239. doi:
10.1111/jcmm.18239. [PMID: 38774996] - Yu Mu, Yalin Yang, Shuang Jiang, Chilu Liu, Yanxing Han, Jiandong Jiang, Yuhong Wang. Benefits of Puerarin on Metabolic Syndrome and Its Associated Cardiovascular Diseases in Rats Fed a High-Fat/High-Sucrose Diet.
Nutrients.
2024 Apr; 16(9):. doi:
10.3390/nu16091273. [PMID: 38732519] - Shiyan Yue, Yunxiang Liu, Rongrong Zhou, Zhilai Zhan, Liping Kang, Luqi Huang, Yuan Yuan, Tiegui Nan. A Highly Sensitive and Rapid Colloidal Gold Immunoassay for Puerarin Detection.
Journal of agricultural and food chemistry.
2024 Apr; 72(15):8817-8822. doi:
10.1021/acs.jafc.4c00644. [PMID: 38578981] - Xin Wang, Yufeng Jin, Can Di, Yupeng Zeng, Yuqing Zhou, Yu Chen, Zhijun Pan, Zhongxia Li, Wenhua Ling. Supplementation of Silymarin Alone or in Combination with Salvianolic Acids B and Puerarin Regulates Gut Microbiota and Its Metabolism to Improve High-Fat Diet-Induced NAFLD in Mice.
Nutrients.
2024 Apr; 16(8):. doi:
10.3390/nu16081169. [PMID: 38674860] - Xiaoxue Fang, Xintian Lan, Ming Zhu, Min He, Mengmeng Sun, Yiming Cao, Difu Zhu, Dean Guo, Haoming Luo. Puerarin Induces Macrophage M2 Polarization to Exert Antinonalcoholic Steatohepatitis Pharmacological Activity via the Activation of Autophagy.
Journal of agricultural and food chemistry.
2024 Apr; 72(13):7187-7202. doi:
10.1021/acs.jafc.3c09601. [PMID: 38515289] - Yuhan Lin, Rui Liang, Kairong Xie, Tingting Ma, Jigui Zhang, Tao Xu, Aimei Wang, Shuangyue Liu. Puerarin inhibits cisplatin-induced ototoxicity in mice through regulation of TRPV1-dependent calcium overload.
Biochemical pharmacology.
2024 Feb; 220(?):115962. doi:
10.1016/j.bcp.2023.115962. [PMID: 38043717] - L I Xi, Lin Xiangquan, Chen Dongdong, Liu Hui. B-cell lymphoma-2 phosphorylation at Ser70 site-related autophagy mediates puerarin-inhibited the apoptosis of MC3T3-E1 cells during osteoblastogenesis.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2024 Feb; 44(1):27-34. doi:
10.19852/j.cnki.jtcm.20231024.002. [PMID: 38213236] - Changxuan Li, Yu Liu. Puerarin reduces cell damage from cerebral ischemia-reperfusion by inhibiting ferroptosis.
Biochemical and biophysical research communications.
2024 Jan; 693(?):149324. doi:
10.1016/j.bbrc.2023.149324. [PMID: 38101001] - Wenjing Ta, Jie Wang, Jihong Song, Xingyue Li, Jianxiang Wang, Wen Lu. Elucidation the mechanism of the active ingredient imperatorin promoting drug absorption in cell model.
The Journal of pharmacy and pharmacology.
2024 Jan; ?(?):. doi:
10.1093/jpp/rgad127. [PMID: 38215001] - Xueling Li, Jue Wang, Jiayi Yan, John Cijiang He, Yi Li, Yifei Zhong. Additive renal protective effects between arctigenin and puerarin in diabetic kidney disease.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2024 Jan; 171(?):116107. doi:
10.1016/j.biopha.2023.116107. [PMID: 38215692] - Qiongtao Song, Wenyuan Jian, Yuanyuan Zhang, Qiang Li, Ying Zhao, Rong Liu, Yan Zeng, Fuwen Zhang, Junguo Duan. Puerarin Attenuates Iron Overload-Induced Ferroptosis in Retina through a Nrf2-Mediated Mechanism.
Molecular nutrition & food research.
2024 Jan; ?(?):e2300123. doi:
10.1002/mnfr.202300123. [PMID: 38196088] - Seungmee Lee, Hyeonmi Shin, Jihyun Bae, Taek Lee, Minji Kim, Heung Bae Jeon, Kang Hyun Lee, Hah Young Yoo, Chulhwan Park. Enhanced Enzymatic Synthesis of Puerarin Palmitate with Different Acyl Donors for Lipid Solubility Improvement.
International journal of molecular sciences.
2024 Jan; 25(2):. doi:
10.3390/ijms25020709. [PMID: 38255784] - Jing Yang, Baochao Li, Jiangming Wang, Wenxing Fan. Inhibition of Pyroptosis of Renal Tubular Epithelial Cells by Puerarin via Regulation of lncRNA NEAT1 Ameliorating Chronic Renal Failure.
Iranian journal of kidney diseases.
2024 Jan; 1(1):18-26. doi:
. [PMID: 38308547] - Jianpeng Li, Yanan Li, Xiangke Yuan, Dengfeng Yao, Zongyue Gao, Zhaoyang Niu, Zheng Wang, Yue Zhang. The effective constituent puerarin, from Pueraria lobata, inhibits the proliferation and inflammation of vascular smooth muscle in atherosclerosis through the miR-29b-3p/IGF1 pathway.
Pharmaceutical biology.
2023 Dec; 61(1):1-11. doi:
10.1080/13880209.2022.2099430. [PMID: 36537316] - Yu Lu, Shihao Ge, Haili Zhang, Wen Lu, Xiangli Bao, Shiling Pan, Quanhai Pang. Metabolomic and microbiome analysis of the protective effects of Puerarin against Salmonella Enteritidis Infection in chicks.
BMC veterinary research.
2023 Nov; 19(1):242. doi:
10.1186/s12917-023-03806-x. [PMID: 37990191] - Da-He Qi, Hua Ma, Yuan-Yuan Chen, Ke-Xin Wang, Meng-Meng Ding, Yun-Long Hao, Ye Guo, Ling-Bo Kong. [Research progress in mechanism of puerarin in treating vascular dementia].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2023 Nov; 48(22):5993-6002. doi:
10.19540/j.cnki.cjcmm.20230718.401. [PMID: 38114205] - Biyu Hou, Peng Ma, Xinyu Yang, Xiaoyue Zhao, Li Zhang, Yuerong Zhao, Ping He, Li Zhang, Guanhua Du, Guifen Qiang. In silico prediction and experimental validation to reveal the protective mechanism of Puerarin against excessive extracellular matrix accumulation through inhibiting ferroptosis in diabetic nephropathy.
Journal of ethnopharmacology.
2023 Oct; ?(?):117281. doi:
10.1016/j.jep.2023.117281. [PMID: 37797872] - Si-Hui Li, Yan-Fei Li, Di Wu, Yu Xu, Hui-Jia Yan, Jiang-Ning Hu. Metal-polyphenol microgels for oral delivery of puerarin to alleviate the onset of diabetes.
Drug delivery and translational research.
2023 Sep; ?(?):. doi:
10.1007/s13346-023-01428-2. [PMID: 37768531] - Jongkeun Choi, Yongho Kim, Bekir Engin Eser, Jaehong Han. Theoretical study on the glycosidic C-C bond cleavage of 3''-oxo-puerarin.
Scientific reports.
2023 09; 13(1):16282. doi:
10.1038/s41598-023-43379-1. [PMID: 37770535] - Wenxiang Deng, Wenan Zhang, Qinghu He. Study on the mechanism of puerarin against osteoarthritis from ferroptosis based on network pharmacology and bioinformatics.
Naunyn-Schmiedeberg's archives of pharmacology.
2023 Aug; ?(?):. doi:
10.1007/s00210-023-02653-9. [PMID: 37548663] - Peiyan Jiang, Lianyu Zhou, Linyang Zhao, Xinghang Fei, Zhifei Wang, Tianyao Liu, Yexi Tang, Dabing Li, Hong Gong, Yi Luo, Song Li, Hui Yang, Huiling Liao, Xiaotang Fan. Puerarin attenuates valproate-induced features of ASD in male mice via regulating Slc7a11-dependent ferroptosis.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2023 Jul; ?(?):. doi:
10.1038/s41386-023-01659-4. [PMID: 37491673] - Chunjing Guo, Min Cao, Ningning Diao, Wenxin Wang, Hongxu Geng, Yanguo Su, Tianying Sun, Xinyue Lu, Ming Kong, Daquan Chen. Novel pH-responsive E-selectin targeting natural polysaccharides hybrid micelles for diabetic nephropathy.
Nanomedicine : nanotechnology, biology, and medicine.
2023 Jul; 52(?):102696. doi:
10.1016/j.nano.2023.102696. [PMID: 37394108] - Guo Lian, Xi-Xi Huang, Yan Zeng. Puerarin Induces Ferroptosis in Colorectal Cancer Cells via Triggering NCOA4 Upregulation.
Nutrition and cancer.
2023 Jun; ?(?):1-8. doi:
10.1080/01635581.2023.2216922. [PMID: 37260353] - Jingwen Xu, Zhenhua Tian, Zhe Li, Xiaoshi Du, Yansong Cui, Jiangrong Wang, Mei Gao, Yinglong Hou. Puerarin-Tanshinone IIA Suppresses atherosclerosis inflammatory plaque via targeting succinate/HIF-1α/IL-1β axis.
Journal of ethnopharmacology.
2023 May; ?(?):116675. doi:
10.1016/j.jep.2023.116675. [PMID: 37257708] - Li Wang, Tao Wang, Shuangquan Wen, Ruilong Song, Hui Zou, Jianhong Gu, Xuezhong Liu, Jianchun Bian, Zongping Liu, Yan Yuan. Puerarin Prevents Cadmium-Induced Neuronal Injury by Alleviating Autophagic Dysfunction in Rat Cerebral Cortical Neurons.
International journal of molecular sciences.
2023 May; 24(9):. doi:
10.3390/ijms24098328. [PMID: 37176033] - Tian Liu, Kai Su, Weiye Cai, Hui Ao, Mingxiu Li. Therapeutic potential of puerarin against cerebral diseases: From bench to bedside.
European journal of pharmacology.
2023 Mar; ?(?):175695. doi:
10.1016/j.ejphar.2023.175695. [PMID: 36977450] - Zhengdan Wu, Wendan Zeng, Changfu Li, Jihua Wang, Xiaohong Shang, Liang Xiao, Sheng Cao, Yansheng Zhang, Shiqiang Xu, Huabing Yan. Genome-wide identification and expression pattern analysis of R2R3-MYB transcription factor gene family involved in puerarin biosynthesis and response to hormone in Pueraria lobata var. thomsonii.
BMC plant biology.
2023 Feb; 23(1):107. doi:
10.1186/s12870-023-04115-z. [PMID: 36814206] - Huiting Xi, Yaru Zhu, Wenwen Sun, Nan Tang, Zhengqin Xu, Xiaohong Shang, Yansheng Zhang, Huabing Yan, Changfu Li. Comparative Transcriptome Analysis of Pueraria lobata Provides Candidate Genes Involved in Puerarin Biosynthesis and Its Regulation.
Biomolecules.
2023 01; 13(1):. doi:
10.3390/biom13010170. [PMID: 36671554] - Xue-Mei Wan, Chuan Zheng, Xue-Lei Zhou. Puerarin prevents cadmium-induced mitochondrial fission in AML-12 cells via Sirt1-dependent pathway.
Ecotoxicology and environmental safety.
2022 Dec; 248(?):114302. doi:
10.1016/j.ecoenv.2022.114302. [PMID: 36399995] - Fan Meng, Bin Guo, Yi-Qing Ma, Kun-Wei Li, Feng-Ju Niu. Puerarin: A review of its mechanisms of action and clinical studies in ophthalmology.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2022 Dec; 107(?):154465. doi:
10.1016/j.phymed.2022.154465. [PMID: 36166943] - Wenhua Zhang, Mingchang Xu, Shuangquan Wen, Li Wang, Kanglei Zhang, Chaofan Zhang, Hui Zou, Jianhong Gu, Xuezhong Liu, Jianchun Bian, Zongping Liu, Yan Yuan. Puerarin alleviates cadmium-induced rat neurocyte injury by alleviating Nrf2-mediated oxidative stress and inhibiting mitochondrial unfolded protein response.
Ecotoxicology and environmental safety.
2022 Dec; 247(?):114239. doi:
10.1016/j.ecoenv.2022.114239. [PMID: 36326556] - Hua Cheng, Xiaohua Huang, Shuai Wu, Shiyan Wang, Shen Rao, Li Li, Shuiyuan Cheng, Linling Li. Chromosome-Level Genome Assembly and Multi-Omics Dataset Provide Insights into Isoflavone and Puerarin Biosynthesis in Pueraria lobata (Wild.) Ohwi.
Biomolecules.
2022 11; 12(12):. doi:
10.3390/biom12121731. [PMID: 36551157] - Qiuting Mo, Shuping Li, Shiquan You, Dongdong Wang, Jiachan Zhang, Meng Li, Changtao Wang. Puerarin Reduces Oxidative Damage and Photoaging Caused by UVA Radiation in Human Fibroblasts by Regulating Nrf2 and MAPK Signaling Pathways.
Nutrients.
2022 Nov; 14(22):. doi:
10.3390/nu14224724. [PMID: 36432411] - Xia-Xia Zhang, Yan-Fei Lang, Xin Li, Zheng Li, You-Qing Xu, Hong-Qian Chu. The protective effect of puerarin-loaded mesoporous silicon nanoparticles on alcoholic hepatitis through mTOR-mediated autophagy pathway.
Biomedical microdevices.
2022 10; 24(4):37. doi:
10.1007/s10544-022-00622-2. [PMID: 36308627] - Zhen Li, Shengguang Wang, Xinyu Wang, Peng Gao, Shiming Zhang, Yingning Mo, Dongsheng Zhao, Long Dai. Pharmacodynamic Interactions between Puerarin and Metformin in Type-2 Diabetic Rats.
Molecules (Basel, Switzerland).
2022 Oct; 27(21):. doi:
10.3390/molecules27217197. [PMID: 36364022] - Xiao Chang, Yanhong He, Ling Wang, Chuanjin Luo, Yuntao Liu, Rong Li. Puerarin Alleviates LPS-Induced H9C2 Cell Injury by Inducing Mitochondrial Autophagy.
Journal of cardiovascular pharmacology.
2022 10; 80(4):600-608. doi:
10.1097/fjc.0000000000001315. [PMID: 35881898] - Xiaoying Wang, Kai He, Linlin Ma, Lan Wu, Yan Yang, Yanfei Li. Puerarin attenuates isoproterenol‑induced myocardial hypertrophy via inhibition of the Wnt/β‑catenin signaling pathway.
Molecular medicine reports.
2022 10; 26(4):. doi:
10.3892/mmr.2022.12822. [PMID: 35946454] - Zhenzhen Xu, Zakir Hussain Talpur, Wuye Yang, Yinran Xiong, Ting Wu, Yuqi Zhang, Xinyi Shen, Yiping Du. Dual-spectrum online monitoring of puerarin and total flavonoids contents during the extraction process of Pueraria lobata.
Talanta.
2022 Oct; 248(?):123608. doi:
10.1016/j.talanta.2022.123608. [PMID: 35661845] - Jiayang Xu, Xiaoyue Zhang, Lili Yan, Zhichao Zhang, Jing Wei, Luqi Li, Qiang Zhang. Insight into Lotusine and Puerarin in Repairing Alcohol-Induced Metabolic Disorder Based on UPLC-MS/MS.
International journal of molecular sciences.
2022 Sep; 23(18):. doi:
10.3390/ijms231810385. [PMID: 36142292] - Thi Hoa Pham, Gi Ho Lee, Sun Woo Jin, Seung Yeon Lee, Eun Hee Han, Nam Doo Kim, Hye Gwang Jeong. Puerarin attenuates hepatic steatosis via G-protein-coupled estrogen receptor-mediated calcium and SIRT1 signaling pathways.
Phytotherapy research : PTR.
2022 Sep; 36(9):3601-3618. doi:
10.1002/ptr.7526. [PMID: 35871535] - Man Ki Kwok, Gabriel Matthew Leung, Lin Xu, Hung Fat Tse, Tai Hing Lam, C Mary Schooling. Effect of puerarin supplementation on cardiovascular disease risk factors: A randomized, double-blind, placebo-controlled, 2-way crossover trial.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Sep; 153(?):113472. doi:
10.1016/j.biopha.2022.113472. [PMID: 36076498] - Yumin Liu, Ziqi Hu, Jing Wang, Yanjun Liao, Luan Shu. Puerarin alleviates depressive-like behaviors in high-fat diet-induced diabetic mice via modulating hippocampal GLP-1R/BDNF/TrkB signaling.
Nutritional neuroscience.
2022 Aug; ?(?):1-14. doi:
10.1080/1028415x.2022.2112439. [PMID: 36039913] - Lijun Du, Li Zhang, Fei Sun. Puerarin Inhibits the Progression of Bladder Cancer by Regulating circ_0020394/miR-328-3p/NRBP1 Axis.
Cancer biotherapy & radiopharmaceuticals.
2022 Aug; 37(6):435-450. doi:
10.1089/cbr.2019.3382. [PMID: 33016781] - Bo Li, Yu Wang, Shiqiang Gong, Weifan Yao, Hua Gao, Mingyan Liu, Minjie Wei. Puerarin improves OVX-induced osteoporosis by regulating phospholipid metabolism and biosynthesis of unsaturated fatty acids based on serum metabolomics.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2022 Jul; 102(?):154198. doi:
10.1016/j.phymed.2022.154198. [PMID: 35636175] - Zeliha Keskin Alkaç, Fatih Ahmet Korkak, Gürdal Dağoğlu, Canan Akdeniz İncili, Betül Dağoğlu Hark, Sadettin Tanyıldızı. Puerarin mitigates oxidative injuries, opening of mitochondrial permeability transition pores and pathological damage associated with liver and kidney in Xanthium strumarium-intoxicated rats.
Toxicon : official journal of the International Society on Toxinology.
2022 Jul; 213(?):13-22. doi:
10.1016/j.toxicon.2022.04.004. [PMID: 35427636] - Qingqing Zhu, Shumin Yang, Chengguo Wei, Geming Lu, Kyung Lee, John Cijiang He, Ruijie Liu, Yifei Zhong. Puerarin attenuates diabetic kidney injury through interaction with Guanidine nucleotide-binding protein Gi subunit alpha-1 (Gnai1) subunit.
Journal of cellular and molecular medicine.
2022 07; 26(14):3816-3827. doi:
10.1111/jcmm.17414. [PMID: 35678269] - Zhiheng Lin, Xiaohui Sui, Wenjian Jiao, Ying Wang, Junde Zhao. Exploring the mechanism and experimental verification of puerarin in the treatment of endometrial carcinoma based on network pharmacology and bioinformatics analysis.
BMC complementary medicine and therapies.
2022 Jun; 22(1):150. doi:
10.1186/s12906-022-03623-z. [PMID: 35672846] - Zi-Tan Peng, Hui Liu. Puerarin attenuates LPS-induced inflammatory injury in gastric epithelial cells by repressing NLRP3 inflammasome-mediated apoptosis.
Toxicology in vitro : an international journal published in association with BIBRA.
2022 Jun; 81(?):105350. doi:
10.1016/j.tiv.2022.105350. [PMID: 35331853] - Huixin Tang, Lingchun Kong, Yuqin Yang, Jingjing Li, Hong Zou. Puerarin suppresses hypoxia-induced vascular endothelial growth factor upregulation in human retinal pigmented epithelial cells by blocking JAK2/STAT3 pathway.
Bioengineered.
2022 05; 13(5):11636-11645. doi:
10.1080/21655979.2022.2070586. [PMID: 35510332] - Xishuai Tong, Gengsheng Yu, Qingyang Liu, Xueqing Zhang, Jianchun Bian, Zongping Liu, Jianhong Gu. Puerarin alleviates cadmium-induced oxidative damage to bone by reducing autophagy in rats.
Environmental toxicology.
2022 Apr; 37(4):720-729. doi:
10.1002/tox.23437. [PMID: 34897960] - Jiayu Lv, Shuqing Shi, Bingxuan Zhang, Xia Xu, Haoran Zheng, Yumeng Li, Xiangning Cui, Huaqin Wu, Qingqiao Song. Role of puerarin in pathological cardiac remodeling: A review.
Pharmacological research.
2022 04; 178(?):106152. doi:
10.1016/j.phrs.2022.106152. [PMID: 35248700] - Shuwen Sun, Chuanbo Ding, Xinglong Liu, Yingchun Zhao, Jinping Zhang, Qiteng Ding, Yiwen Zhang, Yue Zhang, Mingqian Hao, Yinan Zheng, Wencong Liu, Min Yang. Silk protein/polyvinylpyrrolidone nanofiber membranes loaded with puerarin accelerate wound healing in mice by reducing the inflammatory response.
Biomaterials advances.
2022 Apr; 135(?):212734. doi:
10.1016/j.bioadv.2022.212734. [PMID: 35929209] - Ruren Li, Gaibo Yuan, Denghui Li, Chen Xu, Mingying Du, Shuyu Tan, Zhifu Liu, Qing He, Liangyan Rong, Jianrong Li. Enhancing the bioaccessibility of puerarin through the collaboration of high internal phase Pickering emulsions with β-carotene.
Food & function.
2022 Mar; 13(5):2534-2544. doi:
10.1039/d1fo03697a. [PMID: 35156977] - Zhilin Jiang, Xiangning Cui, Peirong Qu, Chang Shang, Mi Xiang, Jie Wang. Roles and mechanisms of puerarin on cardiovascular disease：A review.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Mar; 147(?):112655. doi:
10.1016/j.biopha.2022.112655. [PMID: 35066299] - Lan Mo, Guang-Lei Zhao, Xiao-Feng Li, Ning He, Xing-Long Xiao, Hai-Xia Xu, Yi-Gang Yu. Biocatalytical Acyl-Modification of Puerarin: Shape Gut Microbiota Profile and Improve Short Chain Fatty Acids Production in Rats.
Plant foods for human nutrition (Dordrecht, Netherlands).
2022 Mar; 77(1):44-50. doi:
10.1007/s11130-021-00936-1. [PMID: 34822099] - Bing-Qian Jiang, Guo-Liang Cheng, Yue Zhang, Hui Kong, Jie Zhao, Yifan Zhang, Tong Wu, Yan Zhao, Hui-Hua Qu. Development of a Quantum Dot-Based Fluorescence-Linked Immunosorbent Assay for Puerarin.
Journal of biomedical nanotechnology.
2022 Mar; 18(3):917-921. doi:
10.1166/jbn.2022.3285. [PMID: 35715906] - Li Jiang, Yanling Xiong, Yu Tu, Wentong Zhang, Qiyun Zhang, Peng Nie, Xiaojun Yan, Hongning Liu, Ronghua Liu, Guoliang Xu. Elucidation of the Transport Mechanism of Puerarin and Gastrodin and Their Interaction on the Absorption in a Caco-2 Cell Monolayer Model.
Molecules (Basel, Switzerland).
2022 Feb; 27(4):. doi:
10.3390/molecules27041230. [PMID: 35209020] - Li Wang, Weizhou Jiang, Jing Wang, Yuanyuan Xie, Weisi Wang. Puerarin inhibits FUNDC1-mediated mitochondrial autophagy and CSE-induced apoptosis of human bronchial epithelial cells by activating the PI3K/AKT/mTOR signaling pathway.
Aging.
2022 02; 14(3):1253-1264. doi:
10.18632/aging.203317. [PMID: 35134750] - Ruishuang Ma, Lucy Zhao, Yuming Zhao, Yue Li. Puerarin action on stem cell proliferation, differentiation and apoptosis: Therapeutic implications for geriatric diseases.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2022 Feb; 96(?):153915. doi:
10.1016/j.phymed.2021.153915. [PMID: 35026503] - Laci M Adolfo, Xiaolan Rao, Richard A Dixon. Identification of Pueraria spp. through DNA barcoding and comparative transcriptomics.
BMC plant biology.
2022 Jan; 22(1):10. doi:
10.1186/s12870-021-03383-x. [PMID: 34979934] - Weizheng Liang, Xiushen Li, Hao Wang, Kechao Nie, Qingxue Meng, Junli He, Chunfu Zheng. Puerarin: A Potential Therapeutic for SARS-CoV-2 and Hantavirus Co-Infection.
Frontiers in immunology.
2022; 13(?):892350. doi:
10.3389/fimmu.2022.892350. [PMID: 35663983] - Jingxuan Zhou, Nanhai Zhang, Adil Aldhahrani, Mohamed Mohamed Soliman, Liebing Zhang, Feng Zhou. Puerarin ameliorates nonalcoholic fatty liver in rats by regulating hepatic lipid accumulation, oxidative stress, and inflammation.
Frontiers in immunology.
2022; 13(?):956688. doi:
10.3389/fimmu.2022.956688. [PMID: 35958617] - Lixiu Hu, Yong Xu, Hui Meng. Development and Evaluation of Puerarin Loaded-Albumin Nanoparticles Thermoresponsive in situ Gel for Ophthalmic Delivery.
Drug design, development and therapy.
2022; 16(?):3315-3326. doi:
10.2147/dddt.s374061. [PMID: 36193285] - Yongju Ye, Yang Gao, Yuan Fang, Lixia Xu, Fule He. Anticancer Effect of Puerarin on Ovarian Cancer Progression Contributes to the Tumor Suppressor Gene Expression and Gut Microbiota Modulation.
Journal of immunology research.
2022; 2022(?):4472509. doi:
10.1155/2022/4472509. [PMID: 35935578] - Wen-Bin Wei, Shi-Yan Yue, Rong-Rong Zhou, Tie-Gui Nan, Min Chen, Yuan Yuan. [A monoclonal antibody-based icELISA for puerarin].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2022 Jan; 47(1):48-53. doi:
10.19540/j.cnki.cjcmm.20211025.101. [PMID: 35178910] - Hengyue Zhu, Yanyi Xiao, Hangcheng Guo, Yangyang Guo, Youze Huang, Yunfeng Shan, Yongheng Bai, Xiangyang Lin, Hong Lu. The isoflavone puerarin exerts anti-tumor activity in pancreatic ductal adenocarcinoma by suppressing mTOR-mediated glucose metabolism.
Aging.
2021 12; 13(23):25089-25105. doi:
10.18632/aging.203725. [PMID: 34863080] - Jianjun Li, Chuan Xiong, Pan Xu, Qiang Luo, Ronggui Zhang. Puerarin induces apoptosis in prostate cancer cells via inactivation of the Keap1/Nrf2/ARE signaling pathway.
Bioengineered.
2021 12; 12(1):402-413. doi:
10.1080/21655979.2020.1868733. [PMID: 33356808] - Liang Wang, Baohui Song, Yan Hu, Jun Chen, Shuaishuai Zhang, Dapeng Chen, Jingyu Wang. Puerarin Ameliorates 5-Fluorouracil-Induced Intestinal Mucositis in Mice by Inhibiting JAKs.
The Journal of pharmacology and experimental therapeutics.
2021 11; 379(2):147-155. doi:
10.1124/jpet.121.000677. [PMID: 34400527] - Quanli Liu, Yi Liu, Gang Li, Otto Savolainen, Yun Chen, Jens Nielsen. De novo biosynthesis of bioactive isoflavonoids by engineered yeast cell factories.
Nature communications.
2021 10; 12(1):6085. doi:
10.1038/s41467-021-26361-1. [PMID: 34667183] - Zhifeng Xue, Fangzhe Zhao, Xiaoqing Sang, Yuchuan Qiao, Rui Shao, Yuanyuan Wang, Shan Gao, Guanwei Fan, Yan Zhu, Jian Yang. Combination therapy of tanshinone IIA and puerarin for pulmonary fibrosis via targeting IL6-JAK2-STAT3/STAT1 signaling pathways.
Phytotherapy research : PTR.
2021 Oct; 35(10):5883-5898. doi:
10.1002/ptr.7253. [PMID: 34427348] - Xue-Mei Wan, Jing Chen, Min Wang, Chuan Zheng, Xue-Lei Zhou. Puerarin attenuates cadmium-induced hepatic lipid metabolism disorder by inhibiting oxidative stress and inflammation in mice.
Journal of inorganic biochemistry.
2021 09; 222(?):111521. doi:
10.1016/j.jinorgbio.2021.111521. [PMID: 34171769] - Dawei Lian, Jiaying Liu, Ruifang Han, Jiaqi Jin, Li Zhu, Yanhong Zhang, Yi Huang, Xiao Wang, Shaoxiang Xian, Yang Chen. Kakonein restores diabetes-induced endothelial junction dysfunction via promoting autophagy-mediated NLRP3 inflammasome degradation.
Journal of cellular and molecular medicine.
2021 08; 25(15):7169-7180. doi:
10.1111/jcmm.16747. [PMID: 34180143] - Dan Gao, Jin Hyeok Kim, Cheong Taek Kim, Won Seok Jeong, Hyung Min Kim, Jaehoon Sim, Jong Seong Kang. Evaluation of Anti-Melanogenesis Activity of Enriched Pueraria lobata Stem Extracts and Characterization of Its Phytochemical Components Using HPLC-PDA-ESI-MS/MS.
International journal of molecular sciences.
2021 Jul; 22(15):. doi:
10.3390/ijms22158105. [PMID: 34360871] - Lan Mo, Guang-Lei Zhao, Xiao-Feng Li, Xing-Long Xiao, Ning He, Juan-Juan Ma, Yi-Gang Yu. Evaluation of the digestion and transport profiles and potential immunocompetence of puerarin and its acylated derivatives.
Food & function.
2021 Jul; 12(13):5949-5958. doi:
10.1039/d1fo00555c. [PMID: 34031685] - Lin Zhang, De-Yu Fang, Chun Liu, Dan-Yu Zhao, Yan-Jie Wang, Wen-Na Chen, Yong Cui, Jun-Fu Guo, Pei-Wei Cong, Xiao-Fan Feng, Yun-Ting Zhang. [Mechanism of puerarin reversing SH-SY5Y cell injury induced by Aβ_(1-42) based on proteomics].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2021 Jul; 46(14):3650-3659. doi:
10.19540/j.cnki.cjcmm.20210201.403. [PMID: 34402289] - Xin Jiang, Wenjing Chen, Hang Su, Fuguo Shen, Wenlong Xiao, Wencai Sun. Puerarin facilitates osteogenesis in steroid-induced necrosis of rabbit femoral head and osteogenesis of steroid-induced osteocytes via miR-34a upregulation.
Cytokine.
2021 07; 143(?):155512. doi:
10.1016/j.cyto.2021.155512. [PMID: 33824083] - Xujiao Song, Weihao Wang, Shanshan Ding, Xingyue Liu, Yan Wang, Hao Ma. Puerarin ameliorates depression-like behaviors of with chronic unpredictable mild stress mice by remodeling their gut microbiota.
Journal of affective disorders.
2021 07; 290(?):353-363. doi:
10.1016/j.jad.2021.04.037. [PMID: 34049088] - J Gao, M Liu, Z Guo, C Hu, Z Feng, J Yan. [Puerarin alleviates insulin resistance in type 2 diabetic mice by modulating fetuin B-AMPK/ACC signaling pathway in the liver].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University.
2021 Jun; 41(6):839-846. doi:
10.12122/j.issn.1673-4254.2021.06.05. [PMID: 34238735] - Wenxuan Dong, Kanglei Zhang, Gang Liu, Yun Tan, Hui Zou, Yan Yuan, Jianhong Gu, Ruilong Song, Jiaqiao Zhu, Zongping Liu. Puerarin prevents cadmium-induced disorder of testicular lactic acid metabolism in rats by activating 5' AMP-activated protein kinase (AMPK)/sirtuin 1 (SIRT1) signaling pathway.
Environmental toxicology.
2021 May; 36(5):945-957. doi:
10.1002/tox.23096. [PMID: 33404196] - Yahua Liu, Yan Qiu, Qingguang Chen, Xu Han, Mengjie Cai, Lu Hao. Puerarin suppresses the hepatic gluconeogenesis via activation of PI3K/Akt signaling pathway in diabetic rats and HepG2 cells.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 May; 137(?):111325. doi:
10.1016/j.biopha.2021.111325. [PMID: 33761593] - Meng-Juan Gong, Cai-Yan Zhu, Zhong-Jie Zou, Bin Han, Ping Huang. Therapeutic potential of puerarin against methionine-choline-deficient diet-induced non-alcoholic steatohepatitis determined by combination of 1H NMR spectroscopy-based metabonomics and 16S rRNA gene sequencing.
Journal of pharmaceutical and biomedical analysis.
2021 Apr; 197(?):113964. doi:
10.1016/j.jpba.2021.113964. [PMID: 33601157] - Sureerat Namken, Phanit Songvut, Nitra Nuengchamnong, Taratorn Kemthong, Phisit Khemawoot, Suchinda Malaivijitnond. Comparative Pharmacokinetics of Puerarin Alone and in Pueraria mirifica Extract in Female Cynomolgus Monkeys.
Planta medica.
2021 Apr; 87(5):395-403. doi:
10.1055/a-1271-7092. [PMID: 33063303] - Yan-Hua Wang, Xin Ye, Fan-Jing Meng, Tao Yi, Ji-Fen Zhang. [Study on oral absorption mechanisms of puerarin in nanocrystals self-stabilized pickering emulsion].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2021 Apr; 46(8):2051-2060. doi:
10.19540/j.cnki.cjcmm.20210129.304. [PMID: 33982519] - Zhao-Ming Yu, Xue-Mei Wan, Min Xiao, Chuan Zheng, Xue-Lei Zhou. Puerarin induces Nrf2 as a cytoprotective mechanism to prevent cadmium-induced autophagy inhibition and NLRP3 inflammasome activation in AML12 hepatic cells.
Journal of inorganic biochemistry.
2021 04; 217(?):111389. doi:
10.1016/j.jinorgbio.2021.111389. [PMID: 33607539] - Yuexing Chang, Ailing Guo, Yanlin Jing, Junjie Lin, Yuanyuan Sun, Lulu Kong, Haohang Zheng, Yun Deng. Immunomodulatory activity of puerarin in RAW264.7 macrophages and cyclophosphamide-induced immunosuppression mice.
Immunopharmacology and immunotoxicology.
2021 Apr; 43(2):223-229. doi:
10.1080/08923973.2021.1885043. [PMID: 33583301] - Mengjun Wu, Dan Yi, Qian Zhang, Tao Wu, Kui Yu, Meng Peng, Lei Wang, Di Zhao, Yongqing Hou, Guoyao Wu. Puerarin enhances intestinal function in piglets infected with porcine epidemic diarrhea virus.
Scientific reports.
2021 03; 11(1):6552. doi:
10.1038/s41598-021-85880-5. [PMID: 33753826] - Dong-Xue Xu, Xiao-Xuan Guo, Zhu Zeng, Yong Wang, Jing Qiu. Puerarin improves hepatic glucose and lipid homeostasis in vitro and in vivo by regulating the AMPK pathway.
Food & function.
2021 Mar; 12(6):2726-2740. doi:
10.1039/d0fo02761h. [PMID: 33681875] - Qiang-Song Wang, Yi-Lun Wang, Wen-Yan Zhang, Kuang-Dai Li, Xiong-Fei Luo, Yuan-Lu Cui. Puerarin from Pueraria lobata alleviates the symptoms of irritable bowel syndrome-diarrhea.
Food & function.
2021 Mar; 12(5):2211-2224. doi:
10.1039/d0fo02848g. [PMID: 33595580] - Zunting Pang, Yuanfeng Wei, Hui Chen, Runze Wang, Xin Gao, Jianjun Zhang, Yuan Gao, Shuai Qian. Thermodynamic and kinetic studies on the polymorphic transformations of puerarin hydrates.
International journal of pharmaceutics.
2021 Mar; 597(?):120374. doi:
10.1016/j.ijpharm.2021.120374. [PMID: 33581272] - Liangping Zhao, Li Wang, Daimin Zhang, Yuqi Chen, Fulu Jin. Puerarin alleviates coronary heart disease via suppressing inflammation in a rat model.
Gene.
2021 Mar; 771(?):145354. doi:
10.1016/j.gene.2020.145354. [PMID: 33333215] - Song Liu, Tong Zhou, Dan Chen, Rong Liu, Huan-Huan Qin, Zhen-Li Min, Guang-Qi Liu, Xiao-Lu Cao. In silico-determined compound from the root of Pueraria lobate alleviates synaptic plasticity injury induced by Alzheimer's disease via the p38MAPK-CREB signaling pathway.
Food & function.
2021 Feb; 12(3):1039-1050. doi:
10.1039/d0fo02388d. [PMID: 33433542] - Yu-Shi Liu, Ming-Hao Yuan, Cun-Yan Zhang, Hong-Mei Liu, Juan-Ru Liu, Ai-Ling Wei, Qiang Ye, Bin Zeng, Mei-Feng Li, Yi-Ping Guo, Li Guo. Puerariae Lobatae radix flavonoids and puerarin alleviate alcoholic liver injury in zebrafish by regulating alcohol and lipid metabolism.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Feb; 134(?):111121. doi:
10.1016/j.biopha.2020.111121. [PMID: 33341668] - Muhammad Inam, Lu Liu, Jian-Wei Wang, Ka-Xi Yu, Chi-Uyen Phan, Jie Shen, Wen-Hua Zhang, Guping Tang, Xiurong Hu. Enhancing the Physiochemical Properties of Puerarin via L-Proline Co-Crystallization: Synthesis, Characterization, and Dissolution Studies of Two Phases of Pharmaceutical Co-Crystals.
International journal of molecular sciences.
2021 Jan; 22(2):. doi:
10.3390/ijms22020928. [PMID: 33477727] - Tao Peng, Hanle Shang, Mingrui Yang, Yanjiao Li, Junrong Luo, Mingren Qu, Xinyu Zhang, Xiaozhen Song. Puerarin improved growth performance and postmortem meat quality by regulating lipid metabolism of cattle under hot environment.
Animal science journal = Nihon chikusan Gakkaiho.
2021 Jan; 92(1):e13543. doi:
10.1111/asj.13543. [PMID: 33738872] - Xingyue Qin, Chen Huang, Ka Wu, Yu Li, Xiao Liang, Min Su, Rong Li. Anti-coronavirus disease 2019 (COVID-19) targets and mechanisms of puerarin.
Journal of cellular and molecular medicine.
2021 01; 25(2):677-685. doi:
10.1111/jcmm.16117. [PMID: 33241658] - Jingyu Wang, Shuke Ge, Yaqing Wang, Yi Liu, Lihua Qiu, Junying Li, Xin Huang, Li Sun. Puerarin Alleviates UUO-Induced Inflammation and Fibrosis by Regulating the NF-κB P65/STAT3 and TGFβ1/Smads Signaling Pathways.
Drug design, development and therapy.
2021; 15(?):3697-3708. doi:
10.2147/dddt.s321879. [PMID: 34465981]