Puerarin (BioDeep_00000398478)

Main id: BioDeep_00000002636

 

natural product PANOMIX_OTCML-2023 BioNovoGene_Lab2019


代谢物信息卡片


7-hydroxy-3-(4-hydroxyphenyl)-8-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-tetrahydropyranyl]-4-chromenone

化学式: C21H20O9 (416.1107)
中文名称: 葛根素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=CC=C1C2=COC3=C(C2=O)C=CC(=C3C4C(C(C(C(O4)CO)O)O)O)O)O
InChI: InChI=1S/C21H20O9/c22-7-14-17(26)18(27)19(28)21(30-14)15-13(24)6-5-11-16(25)12(8-29-20(11)15)9-1-3-10(23)4-2-9/h1-6,8,14,17-19,21-24,26-28H,7H2

描述信息

D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
Puerarin, an isoflavone extracted from Radix puerariae, is a 5-HT2C receptor antagonist.
Puerarin, an isoflavone extracted from Radix puerariae, is a 5-HT2C receptor antagonist.
Puerarin, an isoflavone extracted from Radix puerariae, is a 5-HT2C receptor antagonist.

同义名列表

14 个代谢物同义名

7-Hydroxy-3-(4-hydroxyphenyl)-8-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]chromen-4-one; Puerarin; 7-hydroxy-3-(4-hydroxyphenyl)-8-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-tetrahydropyranyl]-4-chromenone; 7-hydroxy-3-(4-hydroxyphenyl)-8-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]chromen-4-one; 7-hydroxy-3-(4-hydroxyphenyl)-8-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]chromen-4-one; 7-hydroxy-3-(4-hydroxyphenyl)-8-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-methylol-tetrahydropyran-2-yl]chromone; 8-(beta-D-Glucopyranosyl-7-hydroxy-3- (4-hydroxyphenyl)-4H-1-benzopyran-4-one; 82435_FLUKA; P5555_SIGMA; 3681-99-0; NPI-31G; C10524; 8-Glucosyldaidzein; Puerarin



数据库引用编号

28 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

109 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 CAT, MAPK3, MAPK8, MTOR, NOS3, PIK3C3, PIK3CA, PPARG, PRKAA2, RB1, SQSTM1, STAT3
Peripheral membrane protein 1 MTOR
Endoplasmic reticulum membrane 1 MTOR
Cytoplasmic vesicle, autophagosome 2 PIK3C3, SQSTM1
Nucleus 11 FOS, MAPK3, MAPK8, MTOR, NOS3, PPARA, PPARG, PRKAA2, RB1, SQSTM1, STAT3
autophagosome 2 PIK3C3, SQSTM1
cytosol 14 CAT, FOS, GPT, MAPK3, MAPK8, MTOR, NOS3, PIK3C3, PIK3CA, PPARG, PRKAA2, RB1, SQSTM1, STAT3
dendrite 2 MTOR, PRKAA2
phagocytic vesicle 1 MTOR
phosphatidylinositol 3-kinase complex, class III 1 PIK3C3
nucleoplasm 11 FOS, MAPK3, MAPK8, MTOR, NOS3, PPARA, PPARG, PRKAA2, RB1, SQSTM1, STAT3
RNA polymerase II transcription regulator complex 3 FOS, PPARG, STAT3
Cell membrane 1 P2RX3
Cytoplasmic side 1 MTOR
lamellipodium 1 PIK3CA
Multi-pass membrane protein 1 P2RX3
Golgi apparatus membrane 1 MTOR
Synapse 1 MAPK8
cell surface 1 ICAM1
glutamatergic synapse 3 MAPK3, PIK3C3, SQSTM1
Golgi apparatus 3 MAPK3, NOS3, PRKAA2
Golgi membrane 3 INS, MTOR, NOS3
lysosomal membrane 1 MTOR
neuronal cell body 1 PRKAA2
postsynapse 1 P2RX3
Cytoplasm, cytosol 1 SQSTM1
Lysosome 2 MTOR, SQSTM1
endosome 1 PIK3C3
plasma membrane 6 ICAM1, MAPK3, NOS3, P2RX3, PIK3CA, STAT3
Membrane 6 CAT, ICAM1, MTOR, P2RX3, PIK3C3, PRKAA2
axon 3 MAPK8, P2RX3, PRKAA2
caveola 2 MAPK3, NOS3
extracellular exosome 5 CAT, GPT, ICAM1, MMP9, SQSTM1
Lysosome membrane 1 MTOR
endoplasmic reticulum 2 FOS, SQSTM1
extracellular space 4 ICAM1, IL17A, INS, MMP9
perinuclear region of cytoplasm 3 NOS3, PIK3CA, PPARG
Schaffer collateral - CA1 synapse 1 P2RX3
intercalated disc 1 PIK3CA
mitochondrion 3 CAT, MAPK3, SQSTM1
protein-containing complex 1 CAT
intracellular membrane-bounded organelle 3 CAT, PPARG, SQSTM1
Microsome membrane 1 MTOR
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 1 ICAM1
Secreted 2 IL17A, INS
extracellular region 4 CAT, IL17A, INS, MMP9
Mitochondrion outer membrane 1 MTOR
mitochondrial outer membrane 1 MTOR
hippocampal mossy fiber to CA3 synapse 1 P2RX3
mitochondrial matrix 1 CAT
transcription regulator complex 1 STAT3
external side of plasma membrane 2 ICAM1, IL17A
Secreted, extracellular space, extracellular matrix 1 MMP9
cytoplasmic vesicle 1 SQSTM1
midbody 1 PIK3C3
Cytoplasm, P-body 1 NOS3
P-body 2 NOS3, SQSTM1
Early endosome 1 MAPK3
Membrane raft 1 ICAM1
Cell junction, focal adhesion 1 MAPK3
focal adhesion 3 CAT, ICAM1, MAPK3
spindle 1 RB1
GABA-ergic synapse 1 PIK3C3
Peroxisome 2 CAT, PIK3C3
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
Nucleus, PML body 2 MTOR, SQSTM1
PML body 3 MTOR, RB1, SQSTM1
collagen-containing extracellular matrix 2 ICAM1, MMP9
axoneme 1 PIK3C3
nuclear speck 1 PRKAA2
Cytoplasm, myofibril, sarcomere 1 SQSTM1
Late endosome 3 MAPK3, PIK3C3, SQSTM1
sarcomere 1 SQSTM1
receptor complex 2 P2RX3, PPARG
chromatin 5 FOS, PPARA, PPARG, RB1, STAT3
phagocytic vesicle membrane 1 PIK3C3
cytoskeleton 2 MAPK3, NOS3
sperm midpiece 1 SQSTM1
nuclear envelope 2 MAPK3, MTOR
Endomembrane system 1 MTOR
endosome lumen 1 INS
Membrane, caveola 1 MAPK3
phagophore assembly site 2 PIK3C3, SQSTM1
phosphatidylinositol 3-kinase complex, class III, type I 1 PIK3C3
phosphatidylinositol 3-kinase complex, class III, type II 1 PIK3C3
Cytoplasm, Stress granule 1 NOS3
cytoplasmic stress granule 2 NOS3, PRKAA2
pseudopodium 1 MAPK3
ficolin-1-rich granule lumen 2 CAT, MMP9
secretory granule lumen 2 CAT, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 INS, MAPK3
nuclear matrix 1 FOS
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
tertiary granule lumen 1 MMP9
endocytic vesicle membrane 1 NOS3
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
SWI/SNF complex 1 RB1
immunological synapse 1 ICAM1
presynaptic endosome 1 PIK3C3
aggresome 1 SQSTM1
protein-DNA complex 1 FOS
basal dendrite 1 MAPK8
intracellular non-membrane-bounded organelle 1 SQSTM1
nucleotide-activated protein kinase complex 1 PRKAA2
Lewy body 1 SQSTM1
Cytoplasmic vesicle, phagosome 1 MTOR
Preautophagosomal structure 1 SQSTM1
postsynaptic endosome 1 PIK3C3
transcription factor AP-1 complex 1 FOS
Autolysosome 2 PIK3C3, SQSTM1
catalase complex 1 CAT
inclusion body 1 SQSTM1
chromatin lock complex 1 RB1
Rb-E2F complex 1 RB1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
amphisome 1 SQSTM1


文献列表

  • Yingying Lai, Ningning Yang, Donghao Shi, Xianhui Ma, Yingying Huang, Jingzhou Lu, Xuzi Zhang, Hui Zhou, Weiyang Gao, Cong Mao, Long Wang. Puerarin enhances TFEB-mediated autophagy and attenuates ROS-induced pyroptosis after ischemic injury of random-pattern skin flaps. European journal of pharmacology. 2024 Jul; 974(?):176621. doi: 10.1016/j.ejphar.2024.176621. [PMID: 38679118]
  • Qing Tao, Yu Chen, Qiao Liang, Jianfeng Shi, Zhiguo Wang, Haiyan Min, Qian Gao, Xiaoming Yao, Lei Wang. Puerarin Alleviates Experimental Autoimmune Thyroiditis by Regulating Macrophages. Journal of immunology (Baltimore, Md. : 1950). 2024 Jun; 212(11):1670-1679. doi: 10.4049/jimmunol.2300779. [PMID: 38668725]
  • Tian-Ci Zhang, Yi-Can Lin, Ning-Ning Sun, Shan Liu, Wen-Zhu Hu, Yan Zhao, Xian-Hui Dong, Xiao-Ping He. Icariin, astragaloside a and puerarin mixture attenuates cognitive impairment in APP/PS1 mice via inhibition of ferroptosis-lipid peroxidation. Neurochemistry international. 2024 May; 175(?):105705. doi: 10.1016/j.neuint.2024.105705. [PMID: 38412923]
  • Huizhen Wei, Mengru Sun, Ruixuan Wang, Hairong Zeng, Bei Zhao, Shenyi Jin. Puerarin mitigated LPS-ATP or HG-primed endothelial cells damage and diabetes-associated cardiovascular disease via ROS-NLRP3 signalling. Journal of cellular and molecular medicine. 2024 May; 28(10):e18239. doi: 10.1111/jcmm.18239. [PMID: 38774996]
  • Yu Mu, Yalin Yang, Shuang Jiang, Chilu Liu, Yanxing Han, Jiandong Jiang, Yuhong Wang. Benefits of Puerarin on Metabolic Syndrome and Its Associated Cardiovascular Diseases in Rats Fed a High-Fat/High-Sucrose Diet. Nutrients. 2024 Apr; 16(9):. doi: 10.3390/nu16091273. [PMID: 38732519]
  • Shiyan Yue, Yunxiang Liu, Rongrong Zhou, Zhilai Zhan, Liping Kang, Luqi Huang, Yuan Yuan, Tiegui Nan. A Highly Sensitive and Rapid Colloidal Gold Immunoassay for Puerarin Detection. Journal of agricultural and food chemistry. 2024 Apr; 72(15):8817-8822. doi: 10.1021/acs.jafc.4c00644. [PMID: 38578981]
  • Xin Wang, Yufeng Jin, Can Di, Yupeng Zeng, Yuqing Zhou, Yu Chen, Zhijun Pan, Zhongxia Li, Wenhua Ling. Supplementation of Silymarin Alone or in Combination with Salvianolic Acids B and Puerarin Regulates Gut Microbiota and Its Metabolism to Improve High-Fat Diet-Induced NAFLD in Mice. Nutrients. 2024 Apr; 16(8):. doi: 10.3390/nu16081169. [PMID: 38674860]
  • Xiaoxue Fang, Xintian Lan, Ming Zhu, Min He, Mengmeng Sun, Yiming Cao, Difu Zhu, Dean Guo, Haoming Luo. Puerarin Induces Macrophage M2 Polarization to Exert Antinonalcoholic Steatohepatitis Pharmacological Activity via the Activation of Autophagy. Journal of agricultural and food chemistry. 2024 Apr; 72(13):7187-7202. doi: 10.1021/acs.jafc.3c09601. [PMID: 38515289]
  • Yuhan Lin, Rui Liang, Kairong Xie, Tingting Ma, Jigui Zhang, Tao Xu, Aimei Wang, Shuangyue Liu. Puerarin inhibits cisplatin-induced ototoxicity in mice through regulation of TRPV1-dependent calcium overload. Biochemical pharmacology. 2024 Feb; 220(?):115962. doi: 10.1016/j.bcp.2023.115962. [PMID: 38043717]
  • L I Xi, Lin Xiangquan, Chen Dongdong, Liu Hui. B-cell lymphoma-2 phosphorylation at Ser70 site-related autophagy mediates puerarin-inhibited the apoptosis of MC3T3-E1 cells during osteoblastogenesis. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2024 Feb; 44(1):27-34. doi: 10.19852/j.cnki.jtcm.20231024.002. [PMID: 38213236]
  • Changxuan Li, Yu Liu. Puerarin reduces cell damage from cerebral ischemia-reperfusion by inhibiting ferroptosis. Biochemical and biophysical research communications. 2024 Jan; 693(?):149324. doi: 10.1016/j.bbrc.2023.149324. [PMID: 38101001]
  • Wenjing Ta, Jie Wang, Jihong Song, Xingyue Li, Jianxiang Wang, Wen Lu. Elucidation the mechanism of the active ingredient imperatorin promoting drug absorption in cell model. The Journal of pharmacy and pharmacology. 2024 Jan; ?(?):. doi: 10.1093/jpp/rgad127. [PMID: 38215001]
  • Xueling Li, Jue Wang, Jiayi Yan, John Cijiang He, Yi Li, Yifei Zhong. Additive renal protective effects between arctigenin and puerarin in diabetic kidney disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024 Jan; 171(?):116107. doi: 10.1016/j.biopha.2023.116107. [PMID: 38215692]
  • Qiongtao Song, Wenyuan Jian, Yuanyuan Zhang, Qiang Li, Ying Zhao, Rong Liu, Yan Zeng, Fuwen Zhang, Junguo Duan. Puerarin Attenuates Iron Overload-Induced Ferroptosis in Retina through a Nrf2-Mediated Mechanism. Molecular nutrition & food research. 2024 Jan; ?(?):e2300123. doi: 10.1002/mnfr.202300123. [PMID: 38196088]
  • Seungmee Lee, Hyeonmi Shin, Jihyun Bae, Taek Lee, Minji Kim, Heung Bae Jeon, Kang Hyun Lee, Hah Young Yoo, Chulhwan Park. Enhanced Enzymatic Synthesis of Puerarin Palmitate with Different Acyl Donors for Lipid Solubility Improvement. International journal of molecular sciences. 2024 Jan; 25(2):. doi: 10.3390/ijms25020709. [PMID: 38255784]
  • Jing Yang, Baochao Li, Jiangming Wang, Wenxing Fan. Inhibition of Pyroptosis of Renal Tubular Epithelial Cells by Puerarin via Regulation of lncRNA NEAT1 Ameliorating Chronic Renal Failure. Iranian journal of kidney diseases. 2024 Jan; 1(1):18-26. doi: . [PMID: 38308547]
  • Jianpeng Li, Yanan Li, Xiangke Yuan, Dengfeng Yao, Zongyue Gao, Zhaoyang Niu, Zheng Wang, Yue Zhang. The effective constituent puerarin, from Pueraria lobata, inhibits the proliferation and inflammation of vascular smooth muscle in atherosclerosis through the miR-29b-3p/IGF1 pathway. Pharmaceutical biology. 2023 Dec; 61(1):1-11. doi: 10.1080/13880209.2022.2099430. [PMID: 36537316]
  • Yu Lu, Shihao Ge, Haili Zhang, Wen Lu, Xiangli Bao, Shiling Pan, Quanhai Pang. Metabolomic and microbiome analysis of the protective effects of Puerarin against Salmonella Enteritidis Infection in chicks. BMC veterinary research. 2023 Nov; 19(1):242. doi: 10.1186/s12917-023-03806-x. [PMID: 37990191]
  • Da-He Qi, Hua Ma, Yuan-Yuan Chen, Ke-Xin Wang, Meng-Meng Ding, Yun-Long Hao, Ye Guo, Ling-Bo Kong. [Research progress in mechanism of puerarin in treating vascular dementia]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2023 Nov; 48(22):5993-6002. doi: 10.19540/j.cnki.cjcmm.20230718.401. [PMID: 38114205]
  • Biyu Hou, Peng Ma, Xinyu Yang, Xiaoyue Zhao, Li Zhang, Yuerong Zhao, Ping He, Li Zhang, Guanhua Du, Guifen Qiang. In silico prediction and experimental validation to reveal the protective mechanism of Puerarin against excessive extracellular matrix accumulation through inhibiting ferroptosis in diabetic nephropathy. Journal of ethnopharmacology. 2023 Oct; ?(?):117281. doi: 10.1016/j.jep.2023.117281. [PMID: 37797872]
  • Si-Hui Li, Yan-Fei Li, Di Wu, Yu Xu, Hui-Jia Yan, Jiang-Ning Hu. Metal-polyphenol microgels for oral delivery of puerarin to alleviate the onset of diabetes. Drug delivery and translational research. 2023 Sep; ?(?):. doi: 10.1007/s13346-023-01428-2. [PMID: 37768531]
  • Jongkeun Choi, Yongho Kim, Bekir Engin Eser, Jaehong Han. Theoretical study on the glycosidic C-C bond cleavage of 3''-oxo-puerarin. Scientific reports. 2023 09; 13(1):16282. doi: 10.1038/s41598-023-43379-1. [PMID: 37770535]
  • Wenxiang Deng, Wenan Zhang, Qinghu He. Study on the mechanism of puerarin against osteoarthritis from ferroptosis based on network pharmacology and bioinformatics. Naunyn-Schmiedeberg's archives of pharmacology. 2023 Aug; ?(?):. doi: 10.1007/s00210-023-02653-9. [PMID: 37548663]
  • Peiyan Jiang, Lianyu Zhou, Linyang Zhao, Xinghang Fei, Zhifei Wang, Tianyao Liu, Yexi Tang, Dabing Li, Hong Gong, Yi Luo, Song Li, Hui Yang, Huiling Liao, Xiaotang Fan. Puerarin attenuates valproate-induced features of ASD in male mice via regulating Slc7a11-dependent ferroptosis. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2023 Jul; ?(?):. doi: 10.1038/s41386-023-01659-4. [PMID: 37491673]
  • Chunjing Guo, Min Cao, Ningning Diao, Wenxin Wang, Hongxu Geng, Yanguo Su, Tianying Sun, Xinyue Lu, Ming Kong, Daquan Chen. Novel pH-responsive E-selectin targeting natural polysaccharides hybrid micelles for diabetic nephropathy. Nanomedicine : nanotechnology, biology, and medicine. 2023 Jul; 52(?):102696. doi: 10.1016/j.nano.2023.102696. [PMID: 37394108]
  • Guo Lian, Xi-Xi Huang, Yan Zeng. Puerarin Induces Ferroptosis in Colorectal Cancer Cells via Triggering NCOA4 Upregulation. Nutrition and cancer. 2023 Jun; ?(?):1-8. doi: 10.1080/01635581.2023.2216922. [PMID: 37260353]
  • Jingwen Xu, Zhenhua Tian, Zhe Li, Xiaoshi Du, Yansong Cui, Jiangrong Wang, Mei Gao, Yinglong Hou. Puerarin-Tanshinone IIA Suppresses atherosclerosis inflammatory plaque via targeting succinate/HIF-1α/IL-1β axis. Journal of ethnopharmacology. 2023 May; ?(?):116675. doi: 10.1016/j.jep.2023.116675. [PMID: 37257708]
  • Li Wang, Tao Wang, Shuangquan Wen, Ruilong Song, Hui Zou, Jianhong Gu, Xuezhong Liu, Jianchun Bian, Zongping Liu, Yan Yuan. Puerarin Prevents Cadmium-Induced Neuronal Injury by Alleviating Autophagic Dysfunction in Rat Cerebral Cortical Neurons. International journal of molecular sciences. 2023 May; 24(9):. doi: 10.3390/ijms24098328. [PMID: 37176033]
  • Tian Liu, Kai Su, Weiye Cai, Hui Ao, Mingxiu Li. Therapeutic potential of puerarin against cerebral diseases: From bench to bedside. European journal of pharmacology. 2023 Mar; ?(?):175695. doi: 10.1016/j.ejphar.2023.175695. [PMID: 36977450]
  • Zhengdan Wu, Wendan Zeng, Changfu Li, Jihua Wang, Xiaohong Shang, Liang Xiao, Sheng Cao, Yansheng Zhang, Shiqiang Xu, Huabing Yan. Genome-wide identification and expression pattern analysis of R2R3-MYB transcription factor gene family involved in puerarin biosynthesis and response to hormone in Pueraria lobata var. thomsonii. BMC plant biology. 2023 Feb; 23(1):107. doi: 10.1186/s12870-023-04115-z. [PMID: 36814206]
  • Huiting Xi, Yaru Zhu, Wenwen Sun, Nan Tang, Zhengqin Xu, Xiaohong Shang, Yansheng Zhang, Huabing Yan, Changfu Li. Comparative Transcriptome Analysis of Pueraria lobata Provides Candidate Genes Involved in Puerarin Biosynthesis and Its Regulation. Biomolecules. 2023 01; 13(1):. doi: 10.3390/biom13010170. [PMID: 36671554]
  • Xue-Mei Wan, Chuan Zheng, Xue-Lei Zhou. Puerarin prevents cadmium-induced mitochondrial fission in AML-12 cells via Sirt1-dependent pathway. Ecotoxicology and environmental safety. 2022 Dec; 248(?):114302. doi: 10.1016/j.ecoenv.2022.114302. [PMID: 36399995]
  • Fan Meng, Bin Guo, Yi-Qing Ma, Kun-Wei Li, Feng-Ju Niu. Puerarin: A review of its mechanisms of action and clinical studies in ophthalmology. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Dec; 107(?):154465. doi: 10.1016/j.phymed.2022.154465. [PMID: 36166943]
  • Wenhua Zhang, Mingchang Xu, Shuangquan Wen, Li Wang, Kanglei Zhang, Chaofan Zhang, Hui Zou, Jianhong Gu, Xuezhong Liu, Jianchun Bian, Zongping Liu, Yan Yuan. Puerarin alleviates cadmium-induced rat neurocyte injury by alleviating Nrf2-mediated oxidative stress and inhibiting mitochondrial unfolded protein response. Ecotoxicology and environmental safety. 2022 Dec; 247(?):114239. doi: 10.1016/j.ecoenv.2022.114239. [PMID: 36326556]
  • Hua Cheng, Xiaohua Huang, Shuai Wu, Shiyan Wang, Shen Rao, Li Li, Shuiyuan Cheng, Linling Li. Chromosome-Level Genome Assembly and Multi-Omics Dataset Provide Insights into Isoflavone and Puerarin Biosynthesis in Pueraria lobata (Wild.) Ohwi. Biomolecules. 2022 11; 12(12):. doi: 10.3390/biom12121731. [PMID: 36551157]
  • Qiuting Mo, Shuping Li, Shiquan You, Dongdong Wang, Jiachan Zhang, Meng Li, Changtao Wang. Puerarin Reduces Oxidative Damage and Photoaging Caused by UVA Radiation in Human Fibroblasts by Regulating Nrf2 and MAPK Signaling Pathways. Nutrients. 2022 Nov; 14(22):. doi: 10.3390/nu14224724. [PMID: 36432411]
  • Xia-Xia Zhang, Yan-Fei Lang, Xin Li, Zheng Li, You-Qing Xu, Hong-Qian Chu. The protective effect of puerarin-loaded mesoporous silicon nanoparticles on alcoholic hepatitis through mTOR-mediated autophagy pathway. Biomedical microdevices. 2022 10; 24(4):37. doi: 10.1007/s10544-022-00622-2. [PMID: 36308627]
  • Zhen Li, Shengguang Wang, Xinyu Wang, Peng Gao, Shiming Zhang, Yingning Mo, Dongsheng Zhao, Long Dai. Pharmacodynamic Interactions between Puerarin and Metformin in Type-2 Diabetic Rats. Molecules (Basel, Switzerland). 2022 Oct; 27(21):. doi: 10.3390/molecules27217197. [PMID: 36364022]
  • Xiao Chang, Yanhong He, Ling Wang, Chuanjin Luo, Yuntao Liu, Rong Li. Puerarin Alleviates LPS-Induced H9C2 Cell Injury by Inducing Mitochondrial Autophagy. Journal of cardiovascular pharmacology. 2022 10; 80(4):600-608. doi: 10.1097/fjc.0000000000001315. [PMID: 35881898]
  • Xiaoying Wang, Kai He, Linlin Ma, Lan Wu, Yan Yang, Yanfei Li. Puerarin attenuates isoproterenol‑induced myocardial hypertrophy via inhibition of the Wnt/β‑catenin signaling pathway. Molecular medicine reports. 2022 10; 26(4):. doi: 10.3892/mmr.2022.12822. [PMID: 35946454]
  • Zhenzhen Xu, Zakir Hussain Talpur, Wuye Yang, Yinran Xiong, Ting Wu, Yuqi Zhang, Xinyi Shen, Yiping Du. Dual-spectrum online monitoring of puerarin and total flavonoids contents during the extraction process of Pueraria lobata. Talanta. 2022 Oct; 248(?):123608. doi: 10.1016/j.talanta.2022.123608. [PMID: 35661845]
  • Jiayang Xu, Xiaoyue Zhang, Lili Yan, Zhichao Zhang, Jing Wei, Luqi Li, Qiang Zhang. Insight into Lotusine and Puerarin in Repairing Alcohol-Induced Metabolic Disorder Based on UPLC-MS/MS. International journal of molecular sciences. 2022 Sep; 23(18):. doi: 10.3390/ijms231810385. [PMID: 36142292]
  • Thi Hoa Pham, Gi Ho Lee, Sun Woo Jin, Seung Yeon Lee, Eun Hee Han, Nam Doo Kim, Hye Gwang Jeong. Puerarin attenuates hepatic steatosis via G-protein-coupled estrogen receptor-mediated calcium and SIRT1 signaling pathways. Phytotherapy research : PTR. 2022 Sep; 36(9):3601-3618. doi: 10.1002/ptr.7526. [PMID: 35871535]
  • Man Ki Kwok, Gabriel Matthew Leung, Lin Xu, Hung Fat Tse, Tai Hing Lam, C Mary Schooling. Effect of puerarin supplementation on cardiovascular disease risk factors: A randomized, double-blind, placebo-controlled, 2-way crossover trial. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Sep; 153(?):113472. doi: 10.1016/j.biopha.2022.113472. [PMID: 36076498]
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