FA 15:0 (BioDeep_00000003956)

Secondary id: BioDeep_00000017451, BioDeep_00000265266, BioDeep_00000862761

PANOMIX_OTCML-2023 Antitumor activity

代谢物信息卡片

Dodecanoic acid, 3,7,11-trimethyl-

化学式: C15H30O2 (242.224568)
中文名称: 13-甲基十四烷酸, 12-甲基十四烷酸
谱图信息: 最多检出来源 Homo sapiens(lipidomics) 32.89%

分子结构信息

SMILES: C(C(C)CCC)CCCCCCCCC(=O)O
InChI: InChI=1S/C15H30O2/c1-15(2,3)13-11-9-7-5-4-6-8-10-12-14(16)17/h4-13H2,1-3H3,(H,16,17)

描述信息

A branched-chain saturated fatty acid comprising tetradecanoic acid carrying a 12-methyl substituent.
CONFIDENCE standard compound; INTERNAL_ID 246
CONFIDENCE standard compound; INTERNAL_ID 247
13-Methyltetradecanoic acid (13-MTD), a saturated branched-chain fatty acid with potent anticancer effects. 13-Methyltetradecanoic acid induces apoptosis in many types of human cancer cells[1][2].
13-Methyltetradecanoic acid (13-MTD), a saturated branched-chain fatty acid with potent anticancer effects. 13-Methyltetradecanoic acid induces apoptosis in many types of human cancer cells[1][2].

同义名列表

27 个代谢物同义名

12-methyl-tetradecanoic acid; 12-Methyltetradecanoic acid; Anteisopentadecanoic acid; 12-methyl myristic acid; Sarcinic acid; FA 15:0; 3,5-Dimethyltridecanoic acid; 12,12-dimethyl-tridecanoic acid; 13:0(12Me,12Me); Dodecanoic acid, 3,7,11-trimethyl-; 3,7,11-trimethyl-dodecanoic acid; 3,7,11-Trimethyldodecanoic acid; Farnesylic acid, hexahydro-; Farnesanoic acid; Farnesylic acid; 11-methyl-tetradecanoic acid; 3-methyl-tetradecanoic acid; 2-methyl-tetradecanoic acid; 4,12-dimethyl-tridecanoic acid; 13-methyl-tetradecanoic acid; 13-Methyltetradecanoic acid; Subtilopentadecanoic acid; 13-methylmyristic acid; Isopentadecanoic acid; Isopentadecylic acid; (+)-12-methyl myristic acid; 13-MTD

数据库引用编号

46 个数据库交叉引用编号

ChEBI: CHEBI:39251
ChEBI: CHEBI:196026
ChEBI: CHEBI:196025
ChEBI: CHEBI:196024
ChEBI: CHEBI:196022
ChEBI: CHEBI:196012
ChEBI: CHEBI:39250
KEGG: C16665
PubChem: 56935802
PubChem: 22251831
PubChem: 192736
PubChem: 5282692
PubChem: 5282618
PubChem: 151014
PubChem: 21672
Metlin: METLIN4287
ChEMBL: CHEMBL495851
ChEMBL: CHEMBL495852
LipidMAPS: LMFA01020008
LipidMAPS: LMFA01020389
LipidMAPS: LMFA01020348
LipidMAPS: LMFA01020248
LipidMAPS: LMFA01020163
LipidMAPS: LMFA01020162
LipidMAPS: LMFA01020091
LipidMAPS: LMFA01020037
LipidMAPS: LMFA01020009
CAS: 63237-52-5
CAS: 1190-55-2
CAS: 70641-57-5
CAS: 2485-71-4
CAS: 5502-94-3
MoNA: RP024603
MoNA: RP024602
MoNA: RP024601
MoNA: RP024701
MoNA: RP024702
MoNA: RP024703
PMhub: MS000013789
MetaboLights: MTBLC39251
PubChem: 51090989
NIKKAJI: J387.978J
medchemexpress: HY-131503
HERB: HBIN000906
HERB: HBIN001261
HERB: HBIN001265

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

23 个相关的物种来源信息

72714 - Agelas: 10.1007/BF02536001
295242 - Agelas conifera: 10.1007/BF02536002
178514 - Amphimedon compressa: 10.1021/NP50081A009
469326 - Callyspongia fallax: 10.1021/NP000537Q
3824 - Canavalia gladiata (Jacq.)DC.: -
68574 - Chondrosia reniformis: 10.1021/NP50100A032
942164 - Erylus formosus: 10.1021/NP50073A041
3879 - Medicago sativa: 10.1016/S0031-9422(00)88688-4
5098 - Monascus purpureus: 10.1016/0031-9422(96)00236-1
698782 - Mycale laevis: 10.1021/NP50081A009
1336873 - Myrmekioderma rea: 10.1021/NP50100A032
35924 - Paeonia lactiflora: 10.1016/J.JPBA.2014.10.020
35924 - Paeonia lactiflora Pall.: -
2849249 - Petrosia pellasarca: 10.1021/NP50070A010
33090 - Plants: -
283540 - Pseudosuberites: 10.1021/NP50102A012
4081 - Solanum lycopersicum: 10.3390/MOLECULES23123330
1883 - Streptomyces: 10.1007/BF02976766
714166 - Streptomyces endophyticus: 10.1099/IJS.0.035725-0
417292 - Streptomyces indicus: 10.1099/IJS.0.029389-0
1077945 - Streptomyces manipurensis: 10.1007/S10482-012-9720-4
279590 - Suberites massa: 10.1021/NP50102A012
178552 - Xestospongia muta: 10.1007/BF02535668

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Hiromu Kameoka, Ippo Tsutsui, Katsuharu Saito, Yusuke Kikuchi, Yoshihiro Handa, Tatsuhiro Ezawa, Hideo Hayashi, Masayoshi Kawaguchi, Kohki Akiyama. Stimulation of asymbiotic sporulation in arbuscular mycorrhizal fungi by fatty acids. Nature microbiology. 2019 10; 4(10):1654-1660. doi: 10.1038/s41564-019-0485-7. [PMID: 31235957]
Jonathan D Nickels, Sneha Chatterjee, Christopher B Stanley, Shuo Qian, Xiaolin Cheng, Dean A A Myles, Robert F Standaert, James G Elkins, John Katsaras. The in vivo structure of biological membranes and evidence for lipid domains. PLoS biology. 2017 05; 15(5):e2002214. doi: 10.1371/journal.pbio.2002214. [PMID: 28542493]
Jing Jin, Jiping Chen, Yuzeng Tian, Lili Zou, Longxing Wang, Fang Li. [Determination of undecanoic acid and 13-methyl-tetradecanoic acid connected to the glyceride with internal standard method and its application to the identification of adulteration of illegal cooking oil]. Se pu = Chinese journal of chromatography. 2013 Jun; 31(6):556-60. doi: 10.3724/sp.j.1123.2012.12036. [PMID: 24063195]
Tianxin Lin, XinBao Yin, Qingqing Cai, Xinlan Fan, Kewei Xu, Li Huang, Junhua Luo, Jianping Zheng, Jian Huang. 13-Methyltetradecanoic acid induces mitochondrial-mediated apoptosis in human bladder cancer cells. Urologic oncology. 2012 May; 30(3):339-45. doi: 10.1016/j.urolonc.2010.04.011. [PMID: 20843711]
Yan Zheng, Wen Huang, Jae-Gil Yoo, Jeffrey L Ebersole, Chifu Brad Huang. Antibacterial compounds from Siraitia grosvenorii leaves. Natural product research. 2011 May; 25(9):890-7. doi: 10.1080/14786419.2010.490212. [PMID: 21547839]
Rinat R Ran-Ressler, Ludmila Khailova, Kelly M Arganbright, Camille K Adkins-Rieck, Zeina E Jouni, Omry Koren, Ruth E Ley, J Thomas Brenna, Bohuslav Dvorak. Branched chain fatty acids reduce the incidence of necrotizing enterocolitis and alter gastrointestinal microbial ecology in a neonatal rat model. PloS one. 2011; 6(12):e29032. doi: 10.1371/journal.pone.0029032. [PMID: 22194981]
Ya-Wen He, Ji'en Wu, Jae-Soon Cha, Lian-Hui Zhang. Rice bacterial blight pathogen Xanthomonas oryzae pv. oryzae produces multiple DSF-family signals in regulation of virulence factor production. BMC microbiology. 2010 Jul; 10(?):187. doi: 10.1186/1471-2180-10-187. [PMID: 20615263]
V J Galani, B G Patel, N B Patel. Argyreia speciosa (Linn. f.) sweet: A comprehensive review. Pharmacognosy reviews. 2010 Jul; 4(8):172-8. doi: 10.4103/0973-7847.70913. [PMID: 22228958]
Simone Hauff, Georg Hottinger, Walter Vetter. Enantioselective analysis of chiral anteiso fatty acids in the polar and neutral lipids of food. Lipids. 2010 Apr; 45(4):357-65. doi: 10.1007/s11745-010-3400-9. [PMID: 20221853]
Kyleann K Brooks, Bin Liang, Jennifer L Watts. The influence of bacterial diet on fat storage in C. elegans. PloS one. 2009 Oct; 4(10):e7545. doi: 10.1371/journal.pone.0007545. [PMID: 19844570]
Zoey P Zahorodny Duggan, Heather N Koopman, Suzanne M Budge. Distribution and development of the highly specialized lipids in the sound reception systems of dolphins. Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology. 2009 Aug; 179(6):783-98. doi: 10.1007/s00360-009-0360-6. [PMID: 19373476]
Ana Valéria Colnaghi Simionato, Denise Santos da Silva, Marcio Rodrigues Lambais, Emanuel Carrilho. Characterization of a putative Xylella fastidiosa diffusible signal factor by HRGC-EI-MS. Journal of mass spectrometry : JMS. 2007 Oct; 42(10):1375-81. doi: 10.1002/jms.1325. [PMID: 17902112]
Ana Valéria Colnaghi Simionato, Denise Santos da Silva, Marcio Rodrigues Lambais, Emanuel Carrilho. Characterization of a putative Xylella fastidiosa diffusible signal factor by HRGC-EI-MS. Journal of mass spectrometry : JMS. 2007 Apr; 42(4):490-6. doi: 10.1002/jms.1181. [PMID: 17295415]
Fredrick Lindström, Saskia Thurnhofer, Walter Vetter, Gerhard Gröbner. Impact on lipid membrane organization by free branched-chain fatty acids. Physical chemistry chemical physics : PCCP. 2006 Nov; 8(41):4792-7. doi: 10.1039/b607460j. [PMID: 17043723]
Myung Soo Park, Se Ra Jung, Kang Hyun Lee, Myung-Sook Lee, Jin Ok Do, Seung Bum Kim, Kyung Sook Bae. Chryseobacterium soldanellicola sp. nov. and Chryseobacterium taeanense sp. nov., isolated from roots of sand-dune plants. International journal of systematic and evolutionary microbiology. 2006 Feb; 56(Pt 2):433-438. doi: 10.1099/ijs.0.63825-0. [PMID: 16449453]
Sawitree Wongtangtintharn, Hirosuke Oku, Hironori Iwasaki, Masashi Inafuku, Takayoshi Toda, Teruyoshi Yanagita. Incorporation of branched-chain fatty acid into cellular lipids and caspase-independent apoptosis in human breast cancer cell line, SKBR-3. Lipids in health and disease. 2005 Nov; 4(?):29. doi: 10.1186/1476-511x-4-29. [PMID: 16305741]
Takashi Naka, Nagatoshi Fujiwara, Ikuya Yano, Shinji Maeda, Matsumi Doe, Miki Minamino, Norikazu Ikeda, Yoshiko Kato, Kazuhito Watabe, Yoshio Kumazawa, Ikuko Tomiyasu, Kazuo Kobayashi. Structural analysis of sphingophospholipids derived from Sphingobacterium spiritivorum, the type species of genus Sphingobacterium. Biochimica et biophysica acta. 2003 Dec; 1635(2-3):83-92. doi: 10.1016/j.bbalip.2003.10.010. [PMID: 14729071]
M R Edgcomb, S Sirimanne, B J Wilkinson, P Drouin, R D Morse. Electron paramagnetic resonance studies of the membrane fluidity of the foodborne pathogenic psychrotroph Listeria monocytogenes. Biochimica et biophysica acta. 2000 Jan; 1463(1):31-42. doi: 10.1016/s0005-2736(99)00179-0. [PMID: 10631292]
N Kadri-Hassani, C L Léger, B Descomps. The fatty acid bimodal action on superoxide anion production by human adherent monocytes under phorbol 12-myristate 13-acetate or diacylglycerol activation can be explained by the modulation of protein kinase C and p47phox translocation. The Journal of biological chemistry. 1995 Jun; 270(25):15111-8. doi: 10.1074/jbc.270.25.15111. [PMID: 7797495]
T GERSON, F B SHORLAND, Y ADAMS, M E BELL. Further studies on the metabolism of the (plus)-anteiso-acids, (plus)-12-methyltetradecanoic acid and (plus)-14-methyl-hexadecanoic acid, in the rat. The Biochemical journal. 1959 Dec; 73(?):594-6. doi: 10.1042/bj0730594. [PMID: 13827622]