Tomatine (BioDeep_00000003868)
Secondary id: BioDeep_00000230727
human metabolite PANOMIX_OTCML-2023 Endogenous
代谢物信息卡片
化学式: C50H83NO21 (1033.5457308)
中文名称: 番茄碱 (来自番茄)
谱图信息:
最多检出来源 Viridiplantae(plant) 9.09%
分子结构信息
SMILES: CC1C2C(CC3C4CCC5CC(CCC5(C)C4CCC23C)OC2OC(CO)C(OC3OC(CO)C(O)C(OC4OCC(O)C(O)C4O)C3OC3OC(CO)C(O)C(O)C3O)C(O)C2O)OC11CCC(C)CN1
InChI: InChI=1S/C50H83NO21/c1-20-7-12-50(51-15-20)21(2)32-28(72-50)14-26-24-6-5-22-13-23(8-10-48(22,3)25(24)9-11-49(26,32)4)65-45-40(63)37(60)41(31(18-54)68-45)69-47-43(71-46-39(62)36(59)34(57)29(16-52)66-46)42(35(58)30(17-53)67-47)70-44-38(61)33(56)27(55)19-64-44/h20-47,51-63H,5-19H2,1-4H3
描述信息
Tomatine is a mildly toxic glycoalkaloid or glycospirosolane (steroidal alkaloids whose structure contains a spirosolane skeleton) found in the stems and leaves of tomato plants as well as in the fruit of unripened (green) tomatoes (up to 500 mg/kg). Red, ripe tomatoes have somewhat reduced amounts of tomatine. A toxic dose of tomatine for an adult human would appear to require the consumption of at least 500 g of tomato leaves in one sitting (“Toxic Plants of North America” (Iowa State University Press, 2001)). Tomatine is known to have fungicidal and antimicrobial properties and is likely produced by tomato plants as a defense against bacteria, fungi, viruses, and insects (PMID: 19514731). Some microbes produce an enzyme called tomatinase which can degrade tomatine, rendering it ineffective as an antimicrobial (PMID: 18835993).Tomatine has historically been used as a reagent in analytical chemistry for precipitating cholesterol from solution (PMID: 4362143). When lab animals ingest tomatine, essentially all of it passes through the animal unabsorbed. Tomatine apparently binds to cholesterol in the digestive tract, and the largely insoluble combination is excreted — ridding the body of both the alkaloid and cholesterol. Experiments with hamsters have shown that both tomatine-rich green tomatoes and purified tomatine can substantially lower the levels of undesirable LDL cholesterol while maintaining normal levels of HDL (PMID: 10942315). Experiments with high-tomatine green tomato extracts were recently shown to strongly inhibit the growth of a number of human cancer cell lines including breast (MCF-7), colon (HT-29), gastric (AGS), and hepatoma (liver) (HepG2), as well as normal human liver cells (PMID: 19514731). Other studies have found that purified tomatine is an outstanding immunoadjuvant capable of stimulating potent antigen-specific humoral and cellular immune responses that contribute to protection against malaria, Francisella tularensis and regression of experimental tumors (PMID: 15193398).
Tomatine is a mildly toxic glycoalkaloid or glycospirosolane (steroidal alkaloids whose structure contains a spirosolane skeleton) found in the stems and leaves of tomato plants as well as in the fruit of unripened (green) tomatoes (up to 500 mg/kg). Red, ripe tomatoes have somewhat reduced amounts of tomatine. A toxic dose of tomatine for an adult human would appear to require the consumption of at least 500 g of tomato leaves in one sitting (“Toxic Plants of North America” (Iowa State University Press, 2001)). Tomatine is known to have fungicidal and antimicrobial properties and is likely produced by tomato plants as a defense against bacteria, fungi, viruses, and insects (PMID: 19514731). Some microbes produce an enzyme called tomatinase which can degrade tomatine, rendering it ineffective as an antimicrobial (PMID: 18835993).Tomatine has historically been used as a reagent in analytical chemistry for precipitating cholesterol from solution (PMID: 4362143). When lab animals ingest tomatine, essentially all of it passes through the animal unabsorbed. Tomatine apparently binds to cholesterol in the digestive tract, and the largely insoluble combination is excreted — ridding the body of both the alkaloid and cholesterol. Experiments with hamsters have shown that both tomatine-rich green tomatoes and purified tomatine can substantially lower the levels of undesirable LDL cholesterol while maintaining norma
D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents
D000890 - Anti-Infective Agents > D000935 - Antifungal Agents
Tomatine is a glycoalkaloid, found in the tomato plant (Lycopersicon esculentum Mill.). Tomatine elicits neurotoxicity in RIP1 kinase and caspase-independent manner. Tomatine promotes the upregulation of nuclear apoptosis inducing factor (AIF) in neuroblastoma cells. Tomatine also inhibits 20S proteasome activity[1].
Tomatine is a glycoalkaloid, found in the tomato plant (Lycopersicon esculentum Mill.). Tomatine elicits neurotoxicity in RIP1 kinase and caspase-independent manner. Tomatine promotes the upregulation of nuclear apoptosis inducing factor (AIF) in neuroblastoma cells. Tomatine also inhibits 20S proteasome activity[1].
同义名列表
12 个代谢物同义名
2-[(2-{[4,5-dihydroxy-2-(hydroxymethyl)-6-{5,7,9,13-tetramethyl-5-oxaspiro[pentacyclo[10.8.0.0²,⁹.0⁴,⁸.0¹³,¹⁸]icosane-6,2-piperidine]oxy}oxan-3-yl]oxy}-5-hydroxy-6-(hydroxymethyl)-4-[(3,4,5-trihydroxyoxan-2-yl)oxy]oxan-3-yl)oxy]-6-(hydroxymethyl)oxane-3,4,5-triol; (3beta,5alpha,22beta,25S)-spirosolan-3-yl O-beta-D-glucopyranosyl-(1->2)-O-(beta-D-xylopyranosyl)-(1->3)-O-beta-D-glucopyranosyl-(1->4)-beta-D-galactopyranoside; (22S,25S)-5alpha-spirosolan-3beta-yl beta-D-glucopyranosyl-(1-2)-[beta-D-xylopyranosyl-(1-3)]-beta-D-glucopyranosyl-(1-4)-beta-D-galactopyranoside; Tomatidine, glycoside; alpha -Tomatine; alpha-Tomatine; Lycopersicin; A-Tomatidine; a-Tomatine; Tomatine; Tomatin; α-Tomatine
数据库引用编号
20 个数据库交叉引用编号
- ChEBI: CHEBI:9630
- KEGG: C10827
- PubChem: 28523
- PubChem: 5513
- HMDB: HMDB0034103
- Metlin: METLIN3709
- ChEMBL: CHEMBL525778
- Wikipedia: Tomatine
- LipidMAPS: LMST01150015
- MeSH: Tomatine
- MetaCyc: CPD-17696
- KNApSAcK: C00002268
- foodb: FDB012367
- chemspider: 5312
- CAS: 17406-45-0
- PMhub: MS000012838
- PubChem: 13010
- 3DMET: B04161
- NIKKAJI: J9.099I
- medchemexpress: HY-N2166
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
3 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(3)
- α-tomatine biosynthesis:
cholesterol ⟶ dehydrotomatidine
- α-tomatine biosynthesis:
cholesterol ⟶ dehydrotomatidine
- superpathway of glycoalkaloid metabolism (Solanaceae):
NADP+ + solasodine ⟶ H+ + NADPH + solasod-4-en-3-one
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
25 个相关的物种来源信息
- 7461 - Apis cerana: 10.1371/JOURNAL.PONE.0175573
- 9606 - Homo sapiens: -
- 33090 - Plants: -
- 103871 - Solanum acaule: 10.1021/JF00108A028
- 47970 - Solanum berthaultii: 10.1021/JF00108A028
- 317820 - Solanum chomatophilum: 10.1007/BF02848648
- 315335 - Solanum clarum: 10.1007/BF02848648
- 4109 - Solanum commersonii: 10.1021/JF00108A028
- 50514 - Solanum demissum:
- 50514 - Solanum demissum: -
- 45834 - Solanum dulcamara:
- 200525 - Solanum etuberosum: 10.1007/BF02848648
- 172793 - Solanum jamesii: 10.1007/BF02848648
- 2589398 - Solanum kieseritzkii: 10.1007/BF00565378
- 142760 - Solanum lycopersicoides: 10.5586/ASBP.1986.054
- 4081 - Solanum lycopersicum:
- 4081 - Solanum lycopersicum: 10.1016/S0031-9422(96)00396-2
- 154974 - Solanum ochranthum: 10.1007/BF02848648
- 73575 - Solanum okadae: 10.1007/BF02848648
- 317831 - Solanum oxycarpum: 10.1007/BF02848648
- 4115 - Solanum palustre: 10.1007/BF02848648
- 50273 - Solanum pinnatisectum: 10.1021/JF00108A028
- 62893 - Solanum polyadenium:
- 4113 - Solanum tuberosum: 10.1021/JF60199A001
- 569774 - 金线莲: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Li-Hao Wang, De-Hong Tan, Xue-Song Zhong, Mei-Qi Jia, Xue Ke, Yu-Mei Zhang, Tong Cui, Lin Shi. Review on toxicology and activity of tomato glycoalkaloids in immature tomatoes.
Food chemistry.
2024 Jul; 447(?):138937. doi:
10.1016/j.foodchem.2024.138937
. [PMID: 38492295] - Wesam H Abdulaal, Ulfat M Omar, Mustafa Zeyadi, Dina S El-Agamy, Nabil A Alhakamy, Sabrin R M Ibrahim, Naif A R Almalki, Hani Z Asfour, Mohammed W Al-Rabia, Gamal A Mohamed, Mahmoud Elshal. Modulation of the crosstalk between Keap1/Nrf2/HO-1 and NF-κB signaling pathways by Tomatidine protects against inflammation/oxidative stress-driven fulminant hepatic failure in mice.
International immunopharmacology.
2024 Mar; 130(?):111732. doi:
10.1016/j.intimp.2024.111732
. [PMID: 38402834] - Bo Xu, Min Huang, Hang Qi, Hongzhou Xu, Liang Cai. Tomatidine activates autophagy to improve lung injury and inflammation in sepsis by inhibiting NF-κB and MAPK pathways.
Molecular genetics and genomics : MGG.
2024 Feb; 299(1):14. doi:
10.1007/s00438-024-02109-6
. [PMID: 38400847] - Catarina Faria-Silva, Miriam de Sousa, Manuela Colla Carvalheiro, Pedro Simões, Sandra Simões. Alpha-tomatine and the two sides of the same coin: An anti-nutritional glycoalkaloid with potential in human health.
Food chemistry.
2022 Oct; 391(?):133261. doi:
10.1016/j.foodchem.2022.133261
. [PMID: 35640336] - Junya Fujimaki, Neo Sayama, Shigenobu Shiotani, Takanori Suzuki, Miki Nonaka, Yasuhito Uezono, Mamoru Oyabu, Yasutomi Kamei, Haruo Nukaya, Keiji Wakabayashi, Akihito Morita, Tomoki Sato, Shinji Miura. The Steroidal Alkaloid Tomatidine and Tomatidine-Rich Tomato Leaf Extract Suppress the Human Gastric Cancer-Derived 85As2 Cells In Vitro and In Vivo via Modulation of Interferon-Stimulated Genes.
Nutrients.
2022 Feb; 14(5):. doi:
10.3390/nu14051023
. [PMID: 35267998] - Christian Bailly. The steroidal alkaloids α-tomatine and tomatidine: Panorama of their mode of action and pharmacological properties.
Steroids.
2021 12; 176(?):108933. doi:
10.1016/j.steroids.2021.108933
. [PMID: 34695457] - Rafat Zrieq, Iqrar Ahmad, Mejdi Snoussi, Emira Noumi, Marcello Iriti, Fahad D Algahtani, Harun Patel, Mohd Saeed, Munazzah Tasleem, Shadi Sulaiman, Kaïss Aouadi, Adel Kadri. Tomatidine and Patchouli Alcohol as Inhibitors of SARS-CoV-2 Enzymes (3CLpro, PLpro and NSP15) by Molecular Docking and Molecular Dynamics Simulations.
International journal of molecular sciences.
2021 Oct; 22(19):. doi:
10.3390/ijms221910693
. [PMID: 34639036] - Ryota Akiyama, Masaru Nakayasu, Naoyuki Umemoto, Junpei Kato, Midori Kobayashi, Hyoung Jae Lee, Yukihiro Sugimoto, Yoko Iijima, Kazuki Saito, Toshiya Muranaka, Masaharu Mizutani. Tomato E8 Encodes a C-27 Hydroxylase in Metabolic Detoxification of α-Tomatine during Fruit Ripening.
Plant & cell physiology.
2021 Oct; 62(5):775-783. doi:
10.1093/pcp/pcab080
. [PMID: 34100555] - Masaru Nakayasu, Kohei Ohno, Kyoko Takamatsu, Yuichi Aoki, Shinichi Yamazaki, Hisabumi Takase, Tsubasa Shoji, Kazufumi Yazaki, Akifumi Sugiyama. Tomato roots secrete tomatine to modulate the bacterial assemblage of the rhizosphere.
Plant physiology.
2021 05; 186(1):270-284. doi:
10.1093/plphys/kiab069
. [PMID: 33619554] - Shu-Ju Wu, Wen-Chung Huang, Ming-Chin Yu, Ya-Ling Chen, Szu-Chuan Shen, Kuo-Wei Yeh, Chian-Jiun Liou. Tomatidine ameliorates obesity-induced nonalcoholic fatty liver disease in mice.
The Journal of nutritional biochemistry.
2021 05; 91(?):108602. doi:
10.1016/j.jnutbio.2021.108602
. [PMID: 33548473] - Yaohua You, Jan A L van Kan. Bitter and sweet make tomato hard to (b)eat.
The New phytologist.
2021 04; 230(1):90-100. doi:
10.1111/nph.17104
. [PMID: 33220068] - Ryota Akiyama, Bunta Watanabe, Masaru Nakayasu, Hyoung Jae Lee, Junpei Kato, Naoyuki Umemoto, Toshiya Muranaka, Kazuki Saito, Yukihiro Sugimoto, Masaharu Mizutani. The biosynthetic pathway of potato solanidanes diverged from that of spirosolanes due to evolution of a dioxygenase.
Nature communications.
2021 02; 12(1):1300. doi:
10.1038/s41467-021-21546-0
. [PMID: 33637735] - Marianne Rocha-Hasler, Gabriel Melo de Oliveira, Aline Nefertiti da Gama, Ludmila Ferreira de Almeida Fiuza, Anna Frieda Fesser, Monica Cal, Romina Rocchetti, Raiza Brandão Peres, Xue Li Guan, Marcel Kaiser, Maria de Nazaré Correia Soeiro, Pascal Mäser. Combination With Tomatidine Improves the Potency of Posaconazole Against Trypanosoma cruzi.
Frontiers in cellular and infection microbiology.
2021; 11(?):617917. doi:
10.3389/fcimb.2021.617917
. [PMID: 33747979] - Pengcheng Wang, Juan Bai, Xuewei Liu, Mi Wang, Xianwei Wang, Ping Jiang. Tomatidine inhibits porcine epidemic diarrhea virus replication by targeting 3CL protease.
Veterinary research.
2020 Nov; 51(1):136. doi:
10.1186/s13567-020-00865-y
. [PMID: 33176871] - Farida S Nirmala, Hyunjung Lee, Ji-Sun Kim, Taeyoul Ha, Chang Hwa Jung, Jiyun Ahn. Green Tomato Extract Prevents Bone Loss in Ovariectomized Rats, a Model of Osteoporosis.
Nutrients.
2020 Oct; 12(10):. doi:
10.3390/nu12103210
. [PMID: 33096661] - Anil Ahsan, Yanrong Zheng, Shijia Ma, Mengru Liu, Ming Cao, Yue Li, Wanqing Zheng, Xinyu Zhou, Minhang Xin, Wei-Wei Hu, Zhong Chen, Xiangnan Zhang. Tomatidine protects against ischemic neuronal injury by improving lysosomal function.
European journal of pharmacology.
2020 Sep; 882(?):173280. doi:
10.1016/j.ejphar.2020.173280
. [PMID: 32580039] - Dedong Min, Fujun Li, Xixi Cui, Jingxiang Zhou, Jiaozhuo Li, Wen Ai, Pan Shu, Xinhua Zhang, Xiaoan Li, Demei Meng, Yanyin Guo, Jian Li. SlMYC2 are required for methyl jasmonate-induced tomato fruit resistance to Botrytis cinerea.
Food chemistry.
2020 Apr; 310(?):125901. doi:
10.1016/j.foodchem.2019.125901
. [PMID: 31816533] - Masaru Nakayasu, Ryota Akiyama, Midori Kobayashi, Hyoung Jae Lee, Takashi Kawasaki, Bunta Watanabe, Shingo Urakawa, Junpei Kato, Yukihiro Sugimoto, Yoko Iijima, Kazuki Saito, Toshiya Muranaka, Naoyuki Umemoto, Masaharu Mizutani. Identification of α-Tomatine 23-Hydroxylase Involved in the Detoxification of a Bitter Glycoalkaloid.
Plant & cell physiology.
2020 Jan; 61(1):21-28. doi:
10.1093/pcp/pcz224
. [PMID: 31816045] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964
. [PMID: 31515284] - Hikari Kusu, Hiroki Yoshida, Michiko Kudo, Mai Okuyama, Naoki Harada, Kentaro Tsuji-Naito, Mitsugu Akagawa. Tomatidine Reduces Palmitate-Induced Lipid Accumulation by Activating AMPK via Vitamin D Receptor-Mediated Signaling in Human HepG2 Hepatocytes.
Molecular nutrition & food research.
2019 11; 63(22):e1801377. doi:
10.1002/mnfr.201801377
. [PMID: 31454158] - Marcel René Schumann, Ulrike Brandt, Christian Adis, Lisa Hartung, André Fleißner. Plasma Membrane Integrity During Cell-Cell Fusion and in Response to Pore-Forming Drugs Is Promoted by the Penta-EF-Hand Protein PEF1 in Neurospora crassa.
Genetics.
2019 09; 213(1):195-211. doi:
10.1534/genetics.119.302363
. [PMID: 31270133] - Hyoung Jae Lee, Masaru Nakayasu, Ryota Akiyama, Midori Kobayashi, Haruka Miyachi, Yukihiro Sugimoto, Naoyuki Umemoto, Kazuki Saito, Toshiya Muranaka, Masaharu Mizutani. Identification of a 3β-Hydroxysteroid Dehydrogenase/ 3-Ketosteroid Reductase Involved in α-Tomatine Biosynthesis in Tomato.
Plant & cell physiology.
2019 Jun; 60(6):1304-1315. doi:
10.1093/pcp/pcz049
. [PMID: 30892648] - Zhongxiang Sun, Qi Shi, Qilin Li, Rumeng Wang, Cuicui Xu, Huanhuan Wang, Chunxia Ran, Yuanyuan Song, Rensen Zeng. Identification of a cytochrome P450 CYP6AB60 gene associated with tolerance to multi-plant allelochemicals from a polyphagous caterpillar tobacco cutworm (Spodoptera litura).
Pesticide biochemistry and physiology.
2019 Feb; 154(?):60-66. doi:
10.1016/j.pestbp.2018.12.006
. [PMID: 30765057] - Vignesh K Rangasami, Brijesh Lohchania, Chandrashekhar Voshavar, Harikrishna R Rachamalla, Rajkumar Banerjee, Ashish Dhayani, Saravanabhavan Thangavel, Praveen K Vemula, Srujan Marepally. Exploring membrane permeability of Tomatidine to enhance lipid mediated nucleic acid transfections.
Biochimica et biophysica acta. Biomembranes.
2019 01; 1861(1):327-334. doi:
10.1016/j.bbamem.2018.06.006
. [PMID: 29902420] - Prashant D Sonawane, Uwe Heinig, Sayantan Panda, Netta Segal Gilboa, Meital Yona, S Pradeep Kumar, Noam Alkan, Tamar Unger, Samuel Bocobza, Margarita Pliner, Sergey Malitsky, Maria Tkachev, Sagit Meir, Ilana Rogachev, Asaph Aharoni. Short-chain dehydrogenase/reductase governs steroidal specialized metabolites structural diversity and toxicity in the genus Solanum.
Proceedings of the National Academy of Sciences of the United States of America.
2018 06; 115(23):E5419-E5428. doi:
10.1073/pnas.1804835115
. [PMID: 29784829] - Carlos Rial, Elisabeth Gómez, Rosa M Varela, José M G Molinillo, Francisco A Macías. Ecological Relevance of the Major Allelochemicals in Lycopersicon esculentum Roots and Exudates.
Journal of agricultural and food chemistry.
2018 May; 66(18):4638-4644. doi:
10.1021/acs.jafc.8b01501
. [PMID: 29673247] - Mattia P Arena, Coen Govers, Concetta Lotti, Luigi Ricciardi, Harry J Wichers, Jurriaan J Mes. The Effect of Tomatine on Gene Expression and Cell Monolayer Integrity in Caco-2.
Molecules (Basel, Switzerland).
2018 Mar; 23(3):. doi:
10.3390/molecules23030644
. [PMID: 29533987] - Isabelle Guay, Simon Boulanger, Charles Isabelle, Eric Brouillette, Félix Chagnon, Kamal Bouarab, Eric Marsault, François Malouin. Tomatidine and analog FC04-100 possess bactericidal activities against Listeria, Bacillus and Staphylococcus spp.
BMC pharmacology & toxicology.
2018 02; 19(1):7. doi:
10.1186/s40360-018-0197-2
. [PMID: 29439722] - Morgan J Cichon, Ken M Riedl, Lei Wan, Jennifer M Thomas-Ahner, David M Francis, Steven K Clinton, Steven J Schwartz. Plasma Metabolomics Reveals Steroidal Alkaloids as Novel Biomarkers of Tomato Intake in Mice.
Molecular nutrition & food research.
2017 12; 61(12):. doi:
10.1002/mnfr.201700241
. [PMID: 28795489] - Stéphane Dorsaz, Tiia Snäkä, Quentin Favre-Godal, Pierre Maudens, Nathalie Boulens, Pascal Furrer, Samad Nejad Ebrahimi, Matthias Hamburger, Eric Allémann, Katia Gindro, Emerson Ferreira Queiroz, Howard Riezman, Jean-Luc Wolfender, Dominique Sanglard. Identification and Mode of Action of a Plant Natural Product Targeting Human Fungal Pathogens.
Antimicrobial agents and chemotherapy.
2017 09; 61(9):. doi:
10.1128/aac.00829-17
. [PMID: 28674054] - Daniela Correia da Silva, Paula B Andrade, Patrícia Valentão, David M Pereira. Neurotoxicity of the steroidal alkaloids tomatine and tomatidine is RIP1 kinase- and caspase-independent and involves the eIF2α branch of the endoplasmic reticulum.
The Journal of steroid biochemistry and molecular biology.
2017 07; 171(?):178-186. doi:
10.1016/j.jsbmb.2017.03.009
. [PMID: 28300624] - Jason Carere, Aurélie H Benfield, Mélodie Ollivier, Chunji J Liu, Kemal Kazan, Donald M Gardiner. A tomatinase-like enzyme acts as a virulence factor in the wheat pathogen Fusarium graminearum.
Fungal genetics and biology : FG & B.
2017 03; 100(?):33-41. doi:
10.1016/j.fgb.2017.01.007
. [PMID: 28109774] - Chieh-Ying Kuo, Wen-Chung Huang, Chian-Jiun Liou, Li-Chen Chen, Jiann-Jong Shen, Ming-Ling Kuo. Tomatidine Attenuates Airway Hyperresponsiveness and Inflammation by Suppressing Th2 Cytokines in a Mouse Model of Asthma.
Mediators of inflammation.
2017; 2017(?):5261803. doi:
10.1155/2017/5261803
. [PMID: 29386751] - Jenny Liu, Sierra Kanetake, Yun-Hsuan Wu, Christina Tam, Luisa W Cheng, Kirkwood M Land, Mendel Friedman. Antiprotozoal Effects of the Tomato Tetrasaccharide Glycoalkaloid Tomatine and the Aglycone Tomatidine on Mucosal Trichomonads.
Journal of agricultural and food chemistry.
2016 Nov; 64(46):8806-8810. doi:
10.1021/acs.jafc.6b04030
. [PMID: 27934291] - Jason Carere, Michelle L Colgrave, Jiri Stiller, Chunji Liu, John M Manners, Kemal Kazan, Donald M Gardiner. Enzyme-driven metabolomic screening: a proof-of-principle method for discovery of plant defence compounds targeted by pathogens.
The New phytologist.
2016 Nov; 212(3):770-779. doi:
10.1111/nph.14067
. [PMID: 27353742] - Shiro Yamashoji, Eri Onoda. Detoxification and function of immature tomato.
Food chemistry.
2016 Oct; 209(?):171-6. doi:
10.1016/j.foodchem.2016.04.042
. [PMID: 27173549] - Peng Han, Zhi-Jian Wang, Anne-Violette Lavoir, Thomas Michel, Aurélie Seassau, Wen-Yan Zheng, Chang-Ying Niu, Nicolas Desneux. Increased water salinity applied to tomato plants accelerates the development of the leaf miner Tuta absoluta through bottom-up effects.
Scientific reports.
2016 09; 6(?):32403. doi:
10.1038/srep32403
. [PMID: 27619473] - Emanuela Ventrella, Zbigniew Adamski, Ewa Chudzińska, Mariola Miądowicz-Kobielska, Paweł Marciniak, Ender Büyükgüzel, Kemal Büyükgüzel, Meltem Erdem, Patrizia Falabella, Laura Scrano, Sabino Aurelio Bufo. Solanum tuberosum and Lycopersicon esculentum Leaf Extracts and Single Metabolites Affect Development and Reproduction of Drosophila melanogaster.
PloS one.
2016; 11(5):e0155958. doi:
10.1371/journal.pone.0155958
. [PMID: 27213896] - Simon Boulanger, Gabriel Mitchell, Kamal Bouarab, Éric Marsault, André Cantin, Eric H Frost, Eric Déziel, François Malouin. Bactericidal Effect of Tomatidine-Tobramycin Combination against Methicillin-Resistant Staphylococcus aureus and Pseudomonas aeruginosa Is Enhanced by Interspecific Small-Molecule Interactions.
Antimicrobial agents and chemotherapy.
2015 Dec; 59(12):7458-64. doi:
10.1128/aac.01711-15
. [PMID: 26392496] - Mendel Friedman. Chemistry and anticarcinogenic mechanisms of glycoalkaloids produced by eggplants, potatoes, and tomatoes.
Journal of agricultural and food chemistry.
2015 Apr; 63(13):3323-37. doi:
10.1021/acs.jafc.5b00818
. [PMID: 25821990] - Giovanni Caprioli, Michael Cahill, Serena Logrippo, Kevin James. Elucidation of the mass fragmentation pathways of tomatidine and β1-hydroxytomatine using orbitrap mass spectrometry.
Natural product communications.
2015 Apr; 10(4):575-6. doi:
"
. [PMID: 25973479] - Jorge Mansur Medina, Juliany Cola Fernandes Rodrigues, Otacilio C Moreira, Geórgia Atella, Wanderley de Souza, Hector Barrabin. Mechanisms of growth inhibition of Phytomonas serpens by the alkaloids tomatine and tomatidine.
Memorias do Instituto Oswaldo Cruz.
2015 Feb; 110(1):48-55. doi:
10.1590/0074-02760140097
. [PMID: 25742263] - Giovanni Caprioli, Serena Logrippo, Michael G Cahill, Kevin J James. High-performance liquid chromatography LTQ-Orbitrap mass spectrometry method for tomatidine and non-target metabolites quantification in organic and normal tomatoes.
International journal of food sciences and nutrition.
2014 Dec; 65(8):942-7. doi:
10.3109/09637486.2014.950205
. [PMID: 25156359] - Helen H Tai, Kraig Worrall, Yvan Pelletier, David De Koeyer, Larry A Calhoun. Comparative metabolite profiling of Solanum tuberosum against six wild Solanum species with Colorado potato beetle resistance.
Journal of agricultural and food chemistry.
2014 Sep; 62(36):9043-55. doi:
10.1021/jf502508y
. [PMID: 25144460] - Marcos Taveira, Carla Sousa, Patrícia Valentão, Federico Ferreres, João P Teixeira, Paula B Andrade. Neuroprotective effect of steroidal alkaloids on glutamate-induced toxicity by preserving mitochondrial membrane potential and reducing oxidative stress.
The Journal of steroid biochemistry and molecular biology.
2014 Mar; 140(?):106-15. doi:
10.1016/j.jsbmb.2013.12.013
. [PMID: 24373792] - Sui-Ting Lee, Pooi-Fong Wong, John David Hooper, Mohd Rais Mustafa. Alpha-tomatine synergises with paclitaxel to enhance apoptosis of androgen-independent human prostate cancer PC-3 cells in vitro and in vivo.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2013 Nov; 20(14):1297-305. doi:
10.1016/j.phymed.2013.07.002
. [PMID: 23920276] - Bilal Ökmen, Desalegn W Etalo, Matthieu H A J Joosten, Harro J Bouwmeester, Ric C H de Vos, Jérôme Collemare, Pierre J G M de Wit. Detoxification of α-tomatine by Cladosporium fulvum is required for full virulence on tomato.
The New phytologist.
2013 Jun; 198(4):1203-1214. doi:
10.1111/nph.12208
. [PMID: 23448507] - Kyeong-Mi Choi, Youn-Sun Lee, Dong-Mi Shin, Seunghyun Lee, Kwang-Sik Yoo, Mi Kyeong Lee, Jae-Hak Lee, Sun Yeou Kim, Yong-Moon Lee, Jin-Tae Hong, Yeo-Pyo Yun, Hwan-Soo Yoo. Green tomato extract attenuates high-fat-diet-induced obesity through activation of the AMPK pathway in C57BL/6 mice.
The Journal of nutritional biochemistry.
2013 Jan; 24(1):335-42. doi:
10.1016/j.jnutbio.2012.06.018
. [PMID: 22974972] - J M Medina, J C F Rodrigues, W De Souza, G C Atella, H Barrabin. Tomatidine promotes the inhibition of 24-alkylated sterol biosynthesis and mitochondrial dysfunction in Leishmania amazonensis promastigotes.
Parasitology.
2012 Sep; 139(10):1253-65. doi:
10.1017/s0031182012000522
. [PMID: 22716777] - Yandong Shi, Ubiratan Moura, Isabelle Opitz, Alex Soltermann, Hubert Rehrauer, Svenja Thies, Walter Weder, Rolf A Stahel, Emanuela Felley-Bosco. Role of hedgehog signaling in malignant pleural mesothelioma.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2012 Sep; 18(17):4646-56. doi:
10.1158/1078-0432.ccr-12-0599
. [PMID: 22733539] - Suk Hyun Choi, Jun-Bae Ahn, Nobuyuki Kozukue, Hyun-Jeong Kim, Yosuke Nishitani, Ling Zhang, Masashi Mizuno, Carol E Levin, Mendel Friedman. Structure-activity relationships of α-, β(1)-, γ-, and δ-tomatine and tomatidine against human breast (MDA-MB-231), gastric (KATO-III), and prostate (PC3) cancer cells.
Journal of agricultural and food chemistry.
2012 Apr; 60(15):3891-9. doi:
10.1021/jf3003027
. [PMID: 22482398] - Yukio Fujiwara, Naoko Kiyota, Keiichiro Tsurushima, Makiko Yoshitomi, Hasita Horlad, Tsuyoshi Ikeda, Toshihiro Nohara, Motohiro Takeya, Ryoji Nagai. Tomatidine, a tomato sapogenol, ameliorates hyperlipidemia and atherosclerosis in apoE-deficient mice by inhibiting acyl-CoA:cholesterol acyl-transferase (ACAT).
Journal of agricultural and food chemistry.
2012 Mar; 60(10):2472-9. doi:
10.1021/jf204197r
. [PMID: 22224814] - Federico Ferreres, Marcos Taveira, Angel Gil-Izquierdo, Luísa Oliveira, Tânia Teixeira, Patrícia Valentão, Nelson Simões, Paula B Andrade. High-performance liquid chromatography-diode array detection-electrospray ionization multi-stage mass spectrometric screening of an insect/plant system: the case of Spodoptera littoralis/Lycopersicon esculentum phenolics and alkaloids.
Rapid communications in mass spectrometry : RCM.
2011 Jul; 25(14):1972-80. doi:
10.1002/rcm.5077
. [PMID: 21698680] - Gabriel Mitchell, Mariza Gattuso, Gilles Grondin, Éric Marsault, Kamal Bouarab, François Malouin. Tomatidine inhibits replication of Staphylococcus aureus small-colony variants in cystic fibrosis airway epithelial cells.
Antimicrobial agents and chemotherapy.
2011 May; 55(5):1937-45. doi:
10.1128/aac.01468-10
. [PMID: 21357296] - Hideyuki Manabe, Ayumi Takemoto, Hiromichi Maehara, Mizuho Ohno, Yoshihiro Murakami, Shigeru Itoh, Toshihiro Nohara. Efficient improved extraction of tomato saponin using shock waves.
Chemical & pharmaceutical bulletin.
2011; 59(11):1406-8. doi:
10.1248/cpb.59.1406
. [PMID: 22041080] - Pallavi D Rai, Sadhana J Rajput. Biological Evaluation of Polyherbal Ayurvedic Cardiotonic Preparation 'Mahamrutyunjaya rasa'.
Evidence-based complementary and alternative medicine : eCAM.
2011; 2011(?):. doi:
10.1155/2011/801940
. [PMID: 20953393] - Eric T McDowell, Jeremy Kapteyn, Adam Schmidt, Chao Li, Jin-Ho Kang, Anne Descour, Feng Shi, Matthew Larson, Anthony Schilmiller, Lingling An, A Daniel Jones, Eran Pichersky, Carol A Soderlund, David R Gang. Comparative functional genomic analysis of Solanum glandular trichome types.
Plant physiology.
2011 Jan; 155(1):524-39. doi:
10.1104/pp.110.167114
. [PMID: 21098679] - Sau Har Lee, Indu Bala Jaganath, Seok Mui Wang, Shamala Devi Sekaran. Antimetastatic effects of Phyllanthus on human lung (A549) and breast (MCF-7) cancer cell lines.
PloS one.
2011; 6(6):e20994. doi:
10.1371/journal.pone.0020994
. [PMID: 21698198] - Benoît Remenant, Jean-Charles de Cambiaire, Gilles Cellier, Jonathan M Jacobs, Sophie Mangenot, Valérie Barbe, Aurélie Lajus, David Vallenet, Claudine Medigue, Mark Fegan, Caitilyn Allen, Philippe Prior. Ralstonia syzygii, the Blood Disease Bacterium and some Asian R. solanacearum strains form a single genomic species despite divergent lifestyles.
PloS one.
2011; 6(9):e24356. doi:
10.1371/journal.pone.0024356
. [PMID: 21931687] - Jin-Ho Kang, Guanghui Liu, Feng Shi, A Daniel Jones, Randolph M Beaudry, Gregg A Howe. The tomato odorless-2 mutant is defective in trichome-based production of diverse specialized metabolites and broad-spectrum resistance to insect herbivores.
Plant physiology.
2010 Sep; 154(1):262-72. doi:
10.1104/pp.110.160192
. [PMID: 20668059] - Suk-Hyun Choi, Sang-Hwa Lee, Hyun-Jeong Kim, In-Seon Lee, Nobuyuki Kozukue, Carol E Levin, Mendel Friedman. Changes in free amino acid, phenolic, chlorophyll, carotenoid, and glycoalkaloid contents in tomatoes during 11 stages of growth and inhibition of cervical and lung human cancer cells by green tomato extracts.
Journal of agricultural and food chemistry.
2010 Jul; 58(13):7547-56. doi:
10.1021/jf100162j
. [PMID: 20560602] - Anthony Schilmiller, Feng Shi, Jeongwoon Kim, Amanda L Charbonneau, Daniel Holmes, A Daniel Jones, Robert L Last. Mass spectrometry screening reveals widespread diversity in trichome specialized metabolites of tomato chromosomal substitution lines.
The Plant journal : for cell and molecular biology.
2010 May; 62(3):391-403. doi:
10.1111/j.1365-313x.2010.04154.x
. [PMID: 20113441] - Heather C Rowe, Daniel J Kliebenstein. All mold is not alike: the importance of intraspecific diversity in necrotrophic plant pathogens.
PLoS pathogens.
2010 Mar; 6(3):e1000759. doi:
10.1371/journal.ppat.1000759
. [PMID: 20361052] - Jin-Ho Kang, Feng Shi, A Daniel Jones, M David Marks, Gregg A Howe. Distortion of trichome morphology by the hairless mutation of tomato affects leaf surface chemistry.
Journal of experimental botany.
2010 Feb; 61(4):1053-64. doi:
10.1093/jxb/erp370
. [PMID: 20018901] - Cindy E Morris, Marc Bardin, Linda L Kinkel, Benoit Moury, Philippe C Nicot, David C Sands. Expanding the paradigms of plant pathogen life history and evolution of parasitic fitness beyond agricultural boundaries.
PLoS pathogens.
2009 Dec; 5(12):e1000693. doi:
10.1371/journal.ppat.1000693
. [PMID: 20041212] - Marcello Iriti, Franco Faoro. Chemical diversity and defence metabolism: how plants cope with pathogens and ozone pollution.
International journal of molecular sciences.
2009 Jul; 10(8):3371-3399. doi:
10.3390/ijms10083371
. [PMID: 20111684] - Mendel Friedman, Carol E Levin, Seung-Un Lee, Hyun-Jeong Kim, In-Seon Lee, Jae-Oke Byun, Nobuyuki Kozukue. Tomatine-containing green tomato extracts inhibit growth of human breast, colon, liver, and stomach cancer cells.
Journal of agricultural and food chemistry.
2009 Jul; 57(13):5727-33. doi:
10.1021/jf900364j
. [PMID: 19514731] - Cynthia M Rominger, Wei-Lin Tiger Bee, Robert A Copeland, Elizabeth A Davenport, Aidan Gilmartin, Richard Gontarek, Keith R Hornberger, Lorena A Kallal, Zhihong Lai, Kenneth Lawrie, Quinn Lu, Lynette McMillan, Maggie Truong, Peter J Tummino, Brandon Turunen, Matthew Will, William J Zuercher, David H Rominger. Evidence for allosteric interactions of antagonist binding to the smoothened receptor.
The Journal of pharmacology and experimental therapeutics.
2009 Jun; 329(3):995-1005. doi:
10.1124/jpet.109.152090
. [PMID: 19304771] - Nishant P Visavadiya, A V R L Narasimhacharya. Asparagus root regulates cholesterol metabolism and improves antioxidant status in hypercholesteremic rats.
Evidence-based complementary and alternative medicine : eCAM.
2009 Jun; 6(2):219-26. doi:
10.1093/ecam/nem091
. [PMID: 18955232] - Nobuyuki Kozukue, Kyung-Soon Yoon, Gwang-In Byun, Shuji Misoo, Carol E Levin, Mendel Friedman. Distribution of glycoalkaloids in potato tubers of 59 accessions of two wild and five cultivated Solanum species.
Journal of agricultural and food chemistry.
2008 Dec; 56(24):11920-8. doi:
10.1021/jf802631t
. [PMID: 19053181] - Takao Yamanaka, Jean-Paul Vincken, Pieter de Waard, Mark Sanders, Norihisa Takada, Harry Gruppen. Isolation, characterization, and surfactant properties of the major triterpenoid glycosides from unripe tomato fruits.
Journal of agricultural and food chemistry.
2008 Dec; 56(23):11432-40. doi:
10.1021/jf802351c
. [PMID: 18998702] - Ryan F Seipke, Rosemary Loria. Streptomyces scabies 87-22 possesses a functional tomatinase.
Journal of bacteriology.
2008 Dec; 190(23):7684-92. doi:
10.1128/jb.01010-08
. [PMID: 18835993] - Barry W Walker, Nathan Manhanke, Keith J Stine. Comparison of the interaction of tomatine with mixed monolayers containing phospholipid, egg sphingomyelin, and sterols.
Biochimica et biophysica acta.
2008 Oct; 1778(10):2244-57. doi:
10.1016/j.bbamem.2008.06.004
. [PMID: 18616927] - Yolanda Pareja-Jaime, M Isabel G Roncero, M Carmen Ruiz-Roldán. Tomatinase from Fusarium oxysporum f. sp. lycopersici is required for full virulence on tomato plants.
Molecular plant-microbe interactions : MPMI.
2008 Jun; 21(6):728-36. doi:
10.1094/mpmi-21-6-0728
. [PMID: 18624637] - Yoko Iijima, Yukiko Nakamura, Yoshiyuki Ogata, Ken'ichi Tanaka, Nozomu Sakurai, Kunihiro Suda, Tatsuya Suzuki, Hideyuki Suzuki, Koei Okazaki, Masahiko Kitayama, Shigehiko Kanaya, Koh Aoki, Daisuke Shibata. Metabolite annotations based on the integration of mass spectral information.
The Plant journal : for cell and molecular biology.
2008 Jun; 54(5):949-62. doi:
10.1111/j.1365-313x.2008.03434.x
. [PMID: 18266924] - Chun-Te Chiang, Tzong-Der Way, Shang-Jie Tsai, Jen-Kun Lin. Diosgenin, a naturally occurring steroid, suppresses fatty acid synthase expression in HER2-overexpressing breast cancer cells through modulating Akt, mTOR and JNK phosphorylation.
FEBS letters.
2007 Dec; 581(30):5735-42. doi:
10.1016/j.febslet.2007.11.021
. [PMID: 18022396] - Sayaka Matsushita, Yoshihiro Yanai, Asami Fusyuku, Yukio Fujiwara, Tsuyoshi Ikeda, Masateru Ono, Chunguang Han, Makoto Ojika, Toshihiro Nohara. Efficient conversion of tomatidine into neuritogenic pregnane derivative.
Chemical & pharmaceutical bulletin.
2007 Jul; 55(7):1077-8. doi:
10.1248/cpb.55.1077
. [PMID: 17603206] - Junichiro Enya, Hirosuke Shinohara, Shigenobu Yoshida, Takao Tsukiboshi, Hiromitsu Negishi, Kazuo Suyama, Seiya Tsushima. Culturable leaf-associated bacteria on tomato plants and their potential as biological control agents.
Microbial ecology.
2007 May; 53(4):524-36. doi:
10.1007/s00248-006-9085-1
. [PMID: 17356949] - Veronika Simons, John P Morrissey, Maita Latijnhouwers, Michael Csukai, Adam Cleaver, Carol Yarrow, Anne Osbourn. Dual effects of plant steroidal alkaloids on Saccharomyces cerevisiae.
Antimicrobial agents and chemotherapy.
2006 Aug; 50(8):2732-40. doi:
10.1128/aac.00289-06
. [PMID: 16870766] - I V Benilova, V M Arkhypova, S V Dziadevych, N Jaffrezic-Renault, C Martelet, O P Soldatkin. [Kinetic properties of butyrylcholinesterases immobilised on pH-sensitive field-effect transistor surface and inhibitory action of steroidal glycoalkaloids on these enzymes].
Ukrains'kyi biokhimichnyi zhurnal (1999 ).
2006 Mar; 78(2):131-41. doi:
. [PMID: 17100295]
- Giuseppe Leonardo Rotino, Nazareno Acciarri, Emidio Sabatini, Giuseppe Mennella, Roberto Lo Scalzo, Andrea Maestrelli, Barbara Molesini, Tiziana Pandolfini, Jessica Scalzo, Bruno Mezzetti, Angelo Spena. Open field trial of genetically modified parthenocarpic tomato: seedlessness and fruit quality.
BMC biotechnology.
2005 Dec; 5(?):32. doi:
10.1186/1472-6750-5-32
. [PMID: 16371162] - Olaf Kaup, Ines Gräfen, Eva-Maria Zellermann, Rudolf Eichenlaub, Karl-Heinz Gartemann. Identification of a tomatinase in the tomato-pathogenic actinomycete Clavibacter michiganensis subsp. michiganensis NCPPB382.
Molecular plant-microbe interactions : MPMI.
2005 Oct; 18(10):1090-8. doi:
10.1094/mpmi-18-1090
. [PMID: 16255248] - Ihsan Ergün, M Cenk Akbostanci, Başol Canbakan, Bilge Koçer, Arzu Ensari, Gökhan Nergizoglu, Kenan Keven. Minimal change nephrotic syndrome with stiff-person syndrome: is there a link?.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2005 Jul; 46(1):e11-4. doi:
10.1053/j.ajkd.2005.03.009
. [PMID: 15983949] - Tiina Väänänen, Teemu Ikonen, Veli-Matti Rokka, Pirjo Kuronen, Ritva Serimaa, Velimatti Ollilainen. Influence of incorporated wild Solanum genomes on potato properties in terms of starch nanostructure and glycoalkaloid content.
Journal of agricultural and food chemistry.
2005 Jun; 53(13):5313-25. doi:
10.1021/jf0501342
. [PMID: 15969512] - Tommaso R I Cataldi, Filomena Lelario, Sabino A Bufo. Analysis of tomato glycoalkaloids by liquid chromatography coupled with electrospray ionization tandem mass spectrometry.
Rapid communications in mass spectrometry : RCM.
2005; 19(21):3103-10. doi:
10.1002/rcm.2176
. [PMID: 16200652] - Mendel Friedman. Analysis of biologically active compounds in potatoes (Solanum tuberosum), tomatoes (Lycopersicon esculentum), and jimson weed (Datura stramonium) seeds.
Journal of chromatography. A.
2004 Oct; 1054(1-2):143-55. doi:
10.1016/j.chroma.2004.04.049
. [PMID: 15553139] - Katherine Woods, Chris J Hamilton, Robert A Field. Enzymatic liberation of lycotetraose from the Solanum glycoalkaloid alpha-tomatine.
Carbohydrate research.
2004 Sep; 339(13):2325-8. doi:
10.1016/j.carres.2004.07.004
. [PMID: 15337463] - Shin-ichi Ito, Tomomi Eto, Shuhei Tanaka, Naoki Yamauchi, Hiroyuki Takahara, Tsuyoshi Ikeda. Tomatidine and lycotetraose, hydrolysis products of alpha-tomatine by Fusarium oxysporum tomatinase, suppress induced defense responses in tomato cells.
FEBS letters.
2004 Jul; 571(1-3):31-4. doi:
10.1016/j.febslet.2004.06.053
. [PMID: 15280013] - Kap-Rang Lee, Nobuyuki Kozukue, Jae-Sook Han, Joon-Hong Park, Eun-Young Chang, Eun-Jung Baek, Jong-Sun Chang, Mendel Friedman. Glycoalkaloids and metabolites inhibit the growth of human colon (HT29) and liver (HepG2) cancer cells.
Journal of agricultural and food chemistry.
2004 May; 52(10):2832-9. doi:
10.1021/jf030526d
. [PMID: 15137822] - Samuel P Fletcher, Brian C Geyer, Amy Smith, Tama Evron, Lokesh Joshi, Hermona Soreq, Tsafrir S Mor. Tissue distribution of cholinesterases and anticholinesterases in native and transgenic tomato plants.
Plant molecular biology.
2004 May; 55(1):33-43. doi:
10.1007/s11103-004-0394-9
. [PMID: 15604663] - Nobuyuki Kozukue, Jae-Sook Han, Kap-Rang Lee, Mendel Friedman. Dehydrotomatine and alpha-tomatine content in tomato fruits and vegetative plant tissues.
Journal of agricultural and food chemistry.
2004 Apr; 52(7):2079-83. doi:
10.1021/jf0306845
. [PMID: 15053555] - Encarna Alejandre-Durán, Teresa Roldán-Arjona, Rafael R Ariza, Manuel Ruiz-Rubio. The photolyase gene from the plant pathogen Fusarium oxysporum f. sp. lycopersici is induced by visible light and alpha-tomatine from tomato plant.
Fungal genetics and biology : FG & B.
2003 Nov; 40(2):159-65. doi:
10.1016/s1087-1845(03)00089-6
. [PMID: 14516768] - Marta L del Campo, Carol I Miles. Chemosensory tuning to a host recognition cue in the facultative specialist larvae of the moth Manduca sexta.
The Journal of experimental biology.
2003 Nov; 206(Pt 22):3979-90. doi:
10.1242/jeb.00626
. [PMID: 14555738] - Mendel Friedman, P R Henika, B E Mackey. Effect of feeding solanidine, solasodine and tomatidine to non-pregnant and pregnant mice.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2003 Jan; 41(1):61-71. doi:
10.1016/s0278-6915(02)00205-3
. [PMID: 12453729] - Blanca B Landa, Juana M Cachinero-Díaz, Philippe Lemanceau, Rafael M Jiménez-Díaz, Claude Alabouvette. Effect of fusaric acid and phytoanticipins on growth of rhizobacteria and Fusarium oxysporum.
Canadian journal of microbiology.
2002 Nov; 48(11):971-85. doi:
10.1139/w02-094
. [PMID: 12556125] - Mendel Friedman. Tomato glycoalkaloids: role in the plant and in the diet.
Journal of agricultural and food chemistry.
2002 Oct; 50(21):5751-80. doi:
10.1021/jf020560c
. [PMID: 12358437] - Giuliana Bianco, Philippe Schmitt-Kopplin, Giuseppe De Benedetto, Antonius Kettrup, Tommaso R I Cataldi. Determination of glycoalkaloids and relative aglycones by nonaqueous capillary electrophoresis coupled with electrospray ionization-ion trap mass spectrometry.
Electrophoresis.
2002 Sep; 23(17):2904-12. doi:
10.1002/1522-2683(200209)23:17<2904::aid-elps2904>3.0.co;2-1
. [PMID: 12207298] - K Bouarab, R Melton, J Peart, D Baulcombe, A Osbourn. A saponin-detoxifying enzyme mediates suppression of plant defences.
Nature.
2002 Aug; 418(6900):889-92. doi:
10.1038/nature00950
. [PMID: 12192413] - David J Chitwood. Phytochemical based strategies for nematode control.
Annual review of phytopathology.
2002; 40(?):221-49. doi:
10.1146/annurev.phyto.40.032602.130045
. [PMID: 12147760]