Diosmin (BioDeep_00000000373)

 

Secondary id: BioDeep_00000270488

natural product human metabolite PANOMIX_OTCML-2023 Endogenous BioNovoGene_Lab2019


代谢物信息卡片


5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-((((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one

化学式: C28H32O15 (608.1741)
中文名称: 地奥司明
谱图信息: 最多检出来源 Viridiplantae(plant) 40.94%

分子结构信息

SMILES: c(O)(c3)c(C(=O)2)c(cc3O[C@H](O4)[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@H](O5)[C@H](O)[C@@H]([C@H]([C@@H]5C)O)O)4)OC(=C2)c(c1)ccc(c1O)OC
InChI: InChI=1/C28H32O15/c1-10-21(32)23(34)25(36)27(40-10)39-9-19-22(33)24(35)26(37)28(43-19)41-12-6-14(30)20-15(31)8-17(42-18(20)7-12)11-3-4-16(38-2)13(29)5-11/h3-8,10,19,21-30,32-37H,9H2,1-2H3/t10-,19+,21-,22+,23+,24-,25+,26+,27+,28+/m0/s1

描述信息

Isolated from parsley. Diosmetin 7-rutinoside is found in many foods, some of which are sweet orange, spearmint, rosemary, and peppermint.
C - Cardiovascular system > C05 - Vasoprotectives > C05C - Capillary stabilizing agents > C05CA - Bioflavonoids
Diosmin is found in green vegetables. Diosmin is isolated from parsle
C26170 - Protective Agent > C275 - Antioxidant > C306 - Bioflavonoid
Diosmin is a disaccharide derivative that consists of diosmetin substituted by a 6-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage. It has a role as an antioxidant and an anti-inflammatory agent. It is a glycosyloxyflavone, a rutinoside, a disaccharide derivative, a monomethoxyflavone and a dihydroxyflavanone. It is functionally related to a diosmetin.
Chronic venous insufficiency is a common condition the western population. Compression and pharmacotherapy are frequently used to manage chronic venous insufficiency, improving circulation and symptoms of venous disease. Diosmin is a bioflavonoid isolated from various plants or synthesized from [hesperidin]. It is used for the improvement of capillary fragility or venous insufficiency, including chronic venous insufficiency (CVI) and hemorrhoids. Diosmin is widely available over-the-counter and demonstrates a favourable a favorable safety profile.
Diosmin is a natural product found in Asyneuma argutum, Citrus hystrix, and other organisms with data available.
A bioflavonoid that strengthens vascular walls.
See also: Agathosma betulina leaf (part of).
[Raw Data] CBA89_Diosmin_neg_50eV.txt
[Raw Data] CBA89_Diosmin_pos_10eV.txt
[Raw Data] CBA89_Diosmin_neg_20eV.txt
[Raw Data] CBA89_Diosmin_pos_50eV.txt
[Raw Data] CBA89_Diosmin_neg_30eV.txt
[Raw Data] CBA89_Diosmin_neg_40eV.txt
[Raw Data] CBA89_Diosmin_pos_30eV.txt
[Raw Data] CBA89_Diosmin_neg_10eV.txt
[Raw Data] CBA89_Diosmin_pos_20eV.txt
[Raw Data] CBA89_Diosmin_pos_40eV.txt
Diosmin is a flavonoid found in a variety of citrus fruits and also an agonist of the aryl hydrocarbon receptor (AhR).
Diosmin is a flavonoid found in a variety of citrus fruits and also an agonist of the aryl hydrocarbon receptor (AhR).

同义名列表

89 个代谢物同义名

5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-[(3,4,5-trihydroxy-6-{[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy]methyl}oxan-2-yl)oxy]-4H-chromen-4-one; 5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-[3,4,5-trihydroxy-6-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxymethyl]oxan-2-yl]oxychromen-4-one; 5,7,3-Trihydroxy-4-methoxyflavone 7-O-rutinoside; Luteolin 4-methyl ether 7-rutinoside; Diosmetinidin O-rutinoside; Diosmetin-7-O-rutinoside; Salinigricoflavonoloside; Diosmetin 7-O-rutinoside; Diosmetin 7-rutinoside; Diosmin, ban, inn; Ven-Detrex; Flebosten; Venosmine; Diosminum; Diosmine; Barosmin; Diovenor; Diosmin; Diosmil; Rioven; Daflon; Veno-V; Tovene; 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-((((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one; 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yloxy)methyl)tetrahydro-2H-pyran-2-yloxy)-4H-chromen-4-one; 5-hydroxy-2-(3-hydroxy-4-methoxy-phenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-tetrahydropyran-2-yl]oxymethyl]tetrahydropyran-2-yl]oxy-chromen-4-one; 5-HYDROXY-2-(3-HYDROXY-4-METHOXYPHENYL)-7-{[(2S,3R,4S,5S,6R)-3,4,5-TRIHYDROXY-6-({[(2R,3R,4R,5R,6S)-3,4,5-TRIHYDROXY-6-METHYLOXAN-2-YL]OXY}METHYL)OXAN-2-YL]OXY}-4H-CHROMEN-4-ONE; 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one; 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one; 4H-1-Benzopyran-4-one, 7-((6-O-(6-deoxy-.alpha.-L-mannopyranosyl)-.beta.-D-glucopyranosyl)oxy)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-; 4H-1-Benzopyran-4-one, 7-[[6-O-(6-deoxy-.alpha.-L-mannopyranosyl)-.beta.-D-glucopyranosyl]oxy]-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-; 4H-1-Benzopyran-4-one, 7-((6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-; 7-((6-O-(6-DEOXY-GA-L-MANNOPYRANOSYL)-.BETA.-D-GLUCOPYRANOSYL)OXY)-5-HYDROXY-2-(3-HYDROXY-4-METHOXYPHENYL)-4H-1-BENZOPYRAN-4-ONE; 7-((6-O-(6-Deoxy-ga-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one; 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-oxo-4H-1-benzopyran-7-yl 6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside; 4H-1-Benzopyran-4-one,7-[[6-O-(6-deoxy-a-L-mannopyranosyl)-b-D-glucopyranosyl]oxy]-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-; 5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-((6-O-alpha-L-rhamnopyranosyl-beta-D-glycopyranosyl)oxy)-4-chromenon; 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-(O6-alpha-L-rhamnopyranosyl-beta-D-glucopyranosyloxy)chromen-4-one; 3,5,7-Trihydroxy-4-methoxyflavone-7-(6-O-(-deoxy-alpha-L-mannopyraonsyl)-beta-D-glucopyranoside; Diosmin for system suitability, European Pharmacopoeia (EP) Reference Standard; 3,5-Dihydroxy-4-methoxy-4-oxo-4H-chromen-7-ylrutosid (IUPAC); Diosmin, United States Pharmacopeia (USP) Reference Standard; 3,5-Dihydroxy-4-methoxy-4-oxo-4H-chromen-7-ylrutosid [IUPAC]; Diosmin, European Pharmacopoeia (EP) Reference Standard; 3,5-Dihydroxy-4-methoxy-4-oxo-4H-chromen-7-ylrutosid; 3,5,7-trihydroxy-4-methoxyflavone 7-rhamnoglucoside; 3,5,7-Trihydroxy-4-methoxyflavone 7-rutinoside;; 3,5,7-trihydroxy-4-methoxy flavone-7-rutinoside; 3,5,7-trihydroxy-4-methoxyflavone-7-rutinoside; 3,5,7-Trihydroxy-4-methoxyflavone 7-rutinoside; Diosmin, analytical standard; DIOSMIN [EP MONOGRAPH]; DIOSMIN (EP MONOGRAPH); Diosmine [INN-French]; Diosminum [INN-Latin]; Diosmin [INN-Spanish]; Diosmin [INN:BAN]; DIOSMIN (USP-RS); DIOSMIN [WHO-DD]; DIOSMIN [USP-RS]; DIOSMINE [INCI]; UNII-7QM776WJ5N; DIOSMIN [MART.]; DIOSMIN (MART.); Tox21_111392_1; Diosmin [INN]; Diosmin (INN); DIOSMIN [DSC]; Tox21_111392; DIOSMIN [MI]; Resin, Buchu; Diosmin (8); SMP1_000183; Daflon (TN); Buchu Resin; 7QM776WJ5N; Flebavena; flebosmil; Diosmina; Litosmil; Flebaven; Diosimin; Hemerven; Insuven; Varinon; Diosven; C05CA03; Dioven; Diosmin



数据库引用编号

48 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

119 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 ABCB1, AKT1, ALB, BCL2, CASP3, CAT, CYP1A1, HPGDS, PIK3CA, PTGS2, VEGFA
Peripheral membrane protein 4 ACHE, CYP1A1, GORASP1, PTGS2
Endoplasmic reticulum membrane 3 BCL2, CYP1A1, PTGS2
Nucleus 7 ACHE, AKT1, ALB, BCL2, CASP3, MPO, VEGFA
cytosol 9 AKT1, ALB, BCL2, CASP3, CAT, GPT, GSR, HPGDS, PIK3CA
centrosome 1 ALB
nucleoplasm 4 AKT1, CASP3, HPGDS, MPO
Cell membrane 4 ABCB1, ACHE, AKT1, TNF
Cytoplasmic side 1 GORASP1
lamellipodium 2 AKT1, PIK3CA
Multi-pass membrane protein 1 ABCB1
Golgi apparatus membrane 1 GORASP1
Synapse 1 ACHE
cell cortex 1 AKT1
cell surface 4 ABCB1, ACHE, TNF, VEGFA
glutamatergic synapse 2 AKT1, CASP3
Golgi apparatus 4 ACHE, ALB, GORASP1, VEGFA
Golgi membrane 2 GORASP1, INS
mitochondrial inner membrane 1 CYP1A1
neuromuscular junction 1 ACHE
neuronal cell body 2 CASP3, TNF
postsynapse 1 AKT1
Lysosome 1 MPO
plasma membrane 6 ABCB1, ACHE, AKT1, KNG1, PIK3CA, TNF
Membrane 6 ABCB1, ACHE, AKT1, BCL2, CAT, VEGFA
apical plasma membrane 1 ABCB1
caveola 1 PTGS2
extracellular exosome 7 ABCB1, ALB, CAT, GPT, GSR, KNG1, MPO
endoplasmic reticulum 4 ALB, BCL2, PTGS2, VEGFA
extracellular space 8 ACHE, ALB, IL6, INS, KNG1, MPO, TNF, VEGFA
perinuclear region of cytoplasm 2 ACHE, PIK3CA
adherens junction 1 VEGFA
intercalated disc 1 PIK3CA
mitochondrion 4 BCL2, CAT, CYP1A1, GSR
protein-containing complex 5 AKT1, ALB, BCL2, CAT, PTGS2
intracellular membrane-bounded organelle 4 CAT, CYP1A1, HPGDS, MPO
Microsome membrane 2 CYP1A1, PTGS2
postsynaptic density 1 CASP3
Secreted 5 ACHE, ALB, IL6, INS, VEGFA
extracellular region 9 ACHE, ALB, CAT, IL6, INS, KNG1, MPO, TNF, VEGFA
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
mitochondrial matrix 2 CAT, GSR
Extracellular side 1 ACHE
anchoring junction 1 ALB
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 2 GSR, TNF
Secreted, extracellular space, extracellular matrix 1 VEGFA
microtubule cytoskeleton 1 AKT1
cell-cell junction 1 AKT1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
Apical cell membrane 1 ABCB1
Mitochondrion inner membrane 1 CYP1A1
Membrane raft 1 TNF
pore complex 1 BCL2
focal adhesion 1 CAT
spindle 1 AKT1
cis-Golgi network 1 GORASP1
extracellular matrix 1 VEGFA
Peroxisome 1 CAT
basement membrane 1 ACHE
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 1 KNG1
secretory granule 2 MPO, VEGFA
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
neuron projection 1 PTGS2
ciliary basal body 2 AKT1, ALB
phagocytic cup 1 TNF
centriole 1 ALB
Secreted, extracellular space 1 KNG1
spindle pole 1 ALB
blood microparticle 2 ALB, KNG1
Lipid-anchor, GPI-anchor 1 ACHE
endosome lumen 1 INS
side of membrane 1 ACHE
myelin sheath 1 BCL2
azurophil granule 1 MPO
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 2 CAT, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 5 ALB, IL6, INS, KNG1, PTGS2
platelet alpha granule lumen 3 ALB, KNG1, VEGFA
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
transport vesicle 1 INS
azurophil granule lumen 1 MPO
Endoplasmic reticulum-Golgi intermediate compartment membrane 2 GORASP1, INS
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
phagocytic vesicle lumen 1 MPO
synaptic cleft 1 ACHE
external side of apical plasma membrane 1 ABCB1
death-inducing signaling complex 1 CASP3
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
catalase complex 1 CAT
interleukin-6 receptor complex 1 IL6
BAD-BCL-2 complex 1 BCL2
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
[Isoform H]: Cell membrane 1 ACHE
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
ciliary transition fiber 1 ALB
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Yinai Deng, Peng Yang, Qianle Zhang, Qingwen Wu, Lingfang Feng, Wenjing Shi, Qian Peng, Li Ding, Xukai Tan, Ruoting Zhan, Dongming Ma. Genomic insights into the evolution of flavonoid biosynthesis and O-methyltransferase and glucosyltransferase in Chrysanthemum indicum. Cell reports. 2024 Jan; 43(2):113725. doi: 10.1016/j.celrep.2024.113725. [PMID: 38300800]
  • Kaushal Vyas, Supraja Prabaker, Dhamodharan Prabhu, Meenakumari Sakthivelu, Sundararaj Rajamanikandan, Palaniyandi Velusamy, Chia-Hung Su, Subash C B Gopinath, Raman Pachaiappan. Study of an inhibitory effect of plant polyphenolic compounds against digestive enzymes using bench-working experimental evidence predicted by molecular docking and dynamics. International journal of biological macromolecules. 2024 Jan; 259(Pt 1):129222. doi: 10.1016/j.ijbiomac.2024.129222. [PMID: 38185307]
  • Jingwei Zhao, Mingming Zhang, Huamin Zhang, Ying Wang, Bingyu Chen, Jing Shao. Diosmin ameliorates LPS-induced depression-like behaviors in mice: Inhibition of inflammation and oxidative stress in the prefrontal cortex. Brain research bulletin. 2024 Jan; 206(?):110843. doi: 10.1016/j.brainresbull.2023.110843. [PMID: 38092305]
  • Clare Njoki Kimani, Helmuth Reuter, Sanet Henriët Kotzé, Pieter Venter, Pritika Ramharack, Christo John Frederick Muller. Pancreatic beta cell regenerative potential of Zanthoxylum chalybeum Engl. Aqueous stem bark extract. Journal of ethnopharmacology. 2023 Nov; ?(?):117374. doi: 10.1016/j.jep.2023.117374. [PMID: 37944876]
  • Mehdi Rahimmalek, Antoni Szumny, Shima Gharibi, Natalia Pachura, Mehran Miroliaei, Jacek Łyczko. Chemical Investigations in Kelussia odoratissima Mozaff. Leaves Based on Comprehensive Analytical Methods: LC-MS, SPME, and GC-MS Analyses. Molecules (Basel, Switzerland). 2023 Aug; 28(16):. doi: 10.3390/molecules28166140. [PMID: 37630391]
  • Marcin Feldo, Magdalena Wójciak, Sławomir Dresler, Paweł Sowa, Bartosz J Płachno, Dariusz Samborski, Ireneusz Sowa. Effect of Diosmin on Selected Parameters of Oxygen Homeostasis. International journal of molecular sciences. 2023 Aug; 24(16):. doi: 10.3390/ijms241612917. [PMID: 37629098]
  • K S Kiran, Vivek Hamse Kameshwar, Kiran Kumar Munakudu-Nagaraju, P Nagalambika, R Kavitha, Avathade Karthick, D Guru Kumar, S Nanjunda Swamy, K L Krishna, J R Kumar. Diosmin: A Daboia russelii venom PLA2s inhibitor- purified, and characterized from Oxalis corniculata L medicinal plant. Journal of ethnopharmacology. 2023 Aug; ?(?):116977. doi: 10.1016/j.jep.2023.116977. [PMID: 37544341]
  • Lukasz Gwozdzinski, Joanna Bernasinska-Slomczewska, Anna Wiktorowska-Owczarek, Edward Kowalczyk, Anna Pieniazek. Diosmin and Bromelain Stimulate Glutathione and Total Thiols Production in Red Blood Cells. Molecules (Basel, Switzerland). 2023 Mar; 28(5):. doi: 10.3390/molecules28052291. [PMID: 36903535]
  • Tarique Anwer, Saeed Alshahrani, Ahmad M H Somaili, Abdullah H Khubrani, Rayan A Ahmed, Abdulmajeed M Jali, Ayed Alshamrani, Hina Rashid, Yousra Nomeir, Mohammad Khalid, Mohammad Firoz Alam. Nephroprotective Effect of Diosmin against Cisplatin-Induced Kidney Damage by Modulating IL-1β, IL-6, TNFα and Renal Oxidative Damage. Molecules (Basel, Switzerland). 2023 Jan; 28(3):. doi: 10.3390/molecules28031302. [PMID: 36770968]
  • Seyed Sajad Hossieni Geshnigani, Masoud Mahdavinia, Mojtaba Kalantar, Mehdi Goudarzi, Layasadat Khorsandi, Hadi Kalantar. Diosmin prophylaxis reduces gentamicin-induced kidney damage in rats. Naunyn-Schmiedeberg's archives of pharmacology. 2023 01; 396(1):63-71. doi: 10.1007/s00210-022-02295-3. [PMID: 36121447]
  • Qing-Wen Wu, Min Wei, Ling-Fang Feng, Li Ding, Wu-Ke Wei, Jin-Fen Yang, Xiao-Jing Lin, Hui-Lin Liang, Ruo-Ting Zhan, Dong-Ming Ma. Rhamnosyltransferases involved in the biosynthesis of flavone rutinosides in Chrysanthemum species. Plant physiology. 2022 11; 190(4):2122-2136. doi: 10.1093/plphys/kiac371. [PMID: 35947689]
  • Magdalena Wójciak, Marcin Feldo, Grzegorz Borowski, Tomasz Kubrak, Bartosz J Płachno, Ireneusz Sowa. Antioxidant Potential of Diosmin and Diosmetin against Oxidative Stress in Endothelial Cells. Molecules (Basel, Switzerland). 2022 Nov; 27(23):. doi: 10.3390/molecules27238232. [PMID: 36500323]
  • Johirul Islam, Alpa Shree, Haider Ali Khan, Sarwat Sultana. Chemopreventive potential of Diosmin against benzo[a]pyrene induced lung carcinogenesis in Swiss Albino mice. Journal of biochemical and molecular toxicology. 2022 Nov; 36(11):e23187. doi: 10.1002/jbt.23187. [PMID: 35920545]
  • Piyush Kashyap, Mamta Thakur, Nidhi Singh, Deep Shikha, Shiv Kumar, Poonam Baniwal, Yogender Singh Yadav, Minaxi Sharma, Kandi Sridhar, Baskaran Stephen Inbaraj. In Silico Evaluation of Natural Flavonoids as a Potential Inhibitor of Coronavirus Disease. Molecules (Basel, Switzerland). 2022 Sep; 27(19):. doi: 10.3390/molecules27196374. [PMID: 36234910]
  • Rosa Martha Pérez Gutiérrez, Julio Téllez Gómez, Raúl Borja Urby, José G Contreras Soto, Héctor Romo Parra. Evaluation of Diabetes Effects of Selenium Nanoparticles Synthesized from a Mixture of Luteolin and Diosmin on Streptozotocin-Induced Type 2 Diabetes in Mice. Molecules (Basel, Switzerland). 2022 Sep; 27(17):. doi: 10.3390/molecules27175642. [PMID: 36080407]
  • Hasnaa Osama, Ehdaa O Hamed, Muhammed A Mahmoud, Mohamed E A Abdelrahim. The Effect of Hesperidin and Diosmin Individually or in Combination on Metabolic Profile and Neuropathy among Diabetic Patients with Metabolic Syndrome: A Randomized Controlled Trial. Journal of dietary supplements. 2022 Aug; ?(?):1-14. doi: 10.1080/19390211.2022.2107138. [PMID: 35946912]
  • Marcin Feldo, Magdalena Wójciak, Aleksandra Ziemlewska, Sławomir Dresler, Ireneusz Sowa. Modulatory Effect of Diosmin and Diosmetin on Metalloproteinase Activity and Inflammatory Mediators in Human Skin Fibroblasts Treated with Lipopolysaccharide. Molecules (Basel, Switzerland). 2022 Jul; 27(13):. doi: 10.3390/molecules27134264. [PMID: 35807509]
  • Jiuhong Deng, Chao Zheng, Zhou Hua, Haideng Ci, Guiying Wang, Lijing Chen. Diosmin mitigates high glucose-induced endoplasmic reticulum stress through PI3K/AKT pathway in HK-2 cells. BMC complementary medicine and therapies. 2022 Apr; 22(1):116. doi: 10.1186/s12906-022-03597-y. [PMID: 35477428]
  • Dinesh Kumar, M S Ladaniya, Manju Gurjar, Sunil Kumar. Impact of drying methods on natural antioxidants, phenols and flavanones of immature dropped Citrus sinensis L. Osbeck fruits. Scientific reports. 2022 04; 12(1):6684. doi: 10.1038/s41598-022-10661-7. [PMID: 35461355]
  • Shivani Sharma, Konica Porwal, Chirag Kulkarni, Subhashis Pal, Praveer Sihota, Saroj Kumar, Mahesh Chandra Tiwari, Roshan Katekar, Ashish Kumar, Priya Singh, Swati Rajput, Rajdeep Guha, Navin Kumar, Jiaur R Gayen, Naibedya Chattopadhyay. Diosmin, a citrus fruit-derived phlebotonic bioflavonoid protects rats from chronic kidney disease-induced loss of bone mass and strength without deteriorating the renal function. Food & function. 2022 Feb; 13(4):2184-2199. doi: 10.1039/d1fo03867b. [PMID: 35119062]
  • Samar H Gerges, Sara A Wahdan, Doaa A Elsherbiny, Ebtehal El-Demerdash. Pharmacology of Diosmin, a Citrus Flavone Glycoside: An Updated Review. European journal of drug metabolism and pharmacokinetics. 2022 Jan; 47(1):1-18. doi: 10.1007/s13318-021-00731-y. [PMID: 34687440]
  • Nicolas Monjotin, Guillaume Tenca. Lymphotonic activity of Ruscus extract, hesperidin methyl chalcone and vitamin C in human lymphatic smooth muscle cells. Microvascular research. 2022 01; 139(?):104274. doi: 10.1016/j.mvr.2021.104274. [PMID: 34717967]
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