(R)-Glabridin (BioDeep_00000003700)

Main id: BioDeep_00000229958

 

human metabolite PANOMIX_OTCML-2023


代谢物信息卡片


4-{8,8-dimethyl-2H,3H,4H,8H-pyrano[2,3-f]chromen-3-yl}benzene-1,3-diol

化学式: C20H20O4 (324.13615200000004)
中文名称: 光甘草定
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C12OC(C)(C)C=CC1=C1OC[C@@]([H])(C3C(O)=CC(O)=CC=3)CC1=CC=2
InChI: InChI=1S/C20H20O4/c1-20(2)8-7-16-18(24-20)6-3-12-9-13(11-23-19(12)16)15-5-4-14(21)10-17(15)22/h3-8,10,13,21-22H,9,11H2,1-2H3

描述信息

(R)-Glabridin is found in herbs and spices. (R)-Glabridin is isolated from Glycyrrhiza glabra (licorice).
Isolated from Glycyrrhiza glabra (licorice). (R)-Glabridin is found in tea and herbs and spices.
C26170 - Protective Agent > C275 - Antioxidant > C306 - Bioflavonoid
Glabridin is a natural isoflavan from Glycyrrhiza uralensis, binds to and activates PPARγ, with an EC50 of 6115 nM. Glabridin exhibits antioxidant, anti-bacterial, anti-nephritic, anti-diabetic, anti-fungal, antitumor, anti-inflammatory, antiosteoporotic, cardiovascular protective, neuroprotective and radical scavenging activities[1][2].
Glabridin is a natural isoflavan from Glycyrrhiza uralensis, binds to and activates PPARγ, with an EC50 of 6115 nM. Glabridin exhibits antioxidant, anti-bacterial, anti-nephritic, anti-diabetic, anti-fungal, antitumor, anti-inflammatory, antiosteoporotic, cardiovascular protective, neuroprotective and radical scavenging activities[1][2].
Glabridin is a natural isoflavan from Glycyrrhiza uralensis, binds to and activates PPARγ, with an EC50 of 6115 nM. Glabridin exhibits antioxidant, anti-bacterial, anti-nephritic, anti-diabetic, anti-fungal, antitumor, anti-inflammatory, antiosteoporotic, cardiovascular protective, neuroprotective and radical scavenging activities[1][2].

同义名列表

4 个代谢物同义名

4-{8,8-dimethyl-2H,3H,4H,8H-pyrano[2,3-f]chromen-3-yl}benzene-1,3-diol; 4-{8,8-dimethyl-2H,3H,4H-pyrano[2,3-f]chromen-3-yl}benzene-1,3-diol; (R)-Glabridin; Glabridin



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Guanjie Peng, Yangsi Li, Yiyan Zeng, Bowen Sun, Lanyue Zhang, Qingqing Liu. Effect of glabridin combined with bakuchiol on UVB-induced skin damage and its underlying mechanism: An experimental study. Journal of cosmetic dermatology. 2024 Jun; 23(6):2256-2269. doi: 10.1111/jocd.16259. [PMID: 38497297]
  • Jiyu Weng, Ying Wang, Zekai Tan, Yanghe Yuan, Shiyuan Huang, Zexi Li, Yiming Li, Lanyue Zhang, Zhiyun Du. Glabridin reduces neuroinflammation by modulating inflammatory signals in LPS-induced in vitro and in vivo models. Inflammopharmacology. 2024 Apr; 32(2):1159-1169. doi: 10.1007/s10787-023-01424-5. [PMID: 38372849]
  • Jincai Wen, Wenqing Mu, Hui Li, Yulu Yan, Xiaoyan Zhan, Wei Luo, Zhongxia Wang, Wen Kan, Jia Zhao, Siwen Hui, Ping He, Shuanglin Qin, Yingjie Xu, Ping Zhang, Xiaohe Xiao, Guang Xu, Zhaofang Bai. Glabridin improves autoimmune disease in Trex1-deficient mice by reducing type I interferon production. Molecular medicine (Cambridge, Mass.). 2023 Dec; 29(1):167. doi: 10.1186/s10020-023-00754-y. [PMID: 38066431]
  • Xinshu Zou, Shuang Cai, Tingting Wang, Sidi Zheng, Xilong Cui, Jingyou Hao, Xueying Chen, Yanyan Liu, Zhiyun Zhang, Yanhua Li. Natural Antibacterial Agent-based Nanoparticles for Effective Treatment of Intracellular MRSA Infection. Acta biomaterialia. 2023 Aug; ?(?):. doi: 10.1016/j.actbio.2023.08.004. [PMID: 37557944]
  • Sylvia Kalli, Cindy Vallieres, Joseph Violet, Jan-Willem Sanders, John Chapman, Jean-Paul Vincken, Simon V Avery, Carla Araya-Cloutier. Cellular Responses and Targets in Food Spoilage Yeasts Exposed to Antifungal Prenylated Isoflavonoids. Microbiology spectrum. 2023 Jul; ?(?):e0132723. doi: 10.1128/spectrum.01327-23. [PMID: 37428107]
  • Supaluk Krittanai, Rattanathorn Choonong, Khunkhang Butdapheng, Jakkrit Jabsanthia, Seiichi Sakamoto, Waraporn Putalun. Construction of a monoclonal antibody against glabridin (2G4) and development of an enzyme-linked immunosorbent assay. Phytochemical analysis : PCA. 2023 May; ?(?):. doi: 10.1002/pca.3237. [PMID: 37188651]
  • Mengyao Wang, Feng Zhang, Jie Zhou, Ke Gong, Shasha Chen, Xinran Zhu, Mengxue Zhang, Yajun Duan, Chenzhong Liao, Jihong Han, Zequn Yin. Glabridin Ameliorates Alcohol-Caused Liver Damage by Reducing Oxidative Stress and Inflammation via p38 MAPK/Nrf2/NF-κB Pathway. Nutrients. 2023 Apr; 15(9):. doi: 10.3390/nu15092157. [PMID: 37432306]
  • Saya Yamano, Yuka Tsukuda, Naoko Mizuhara, Yoshihiro Yamaguchi, Akira Ogita, Ken-Ichi Fujita. Dehydrozingerone enhances the fungicidal activity of glabridin against Saccharomyces cerevisiae and Candida albicans. Letters in applied microbiology. 2023 Apr; 76(4):. doi: 10.1093/lambio/ovad040. [PMID: 36990694]
  • Navid Jamali, Ehsan Heidari Soureshjani, Gholam-Reza Mobini, Mohammad Samare-Najaf, Cain C T Clark, Javad Saffari-Chaleshtori. Medicinal plant compounds as promising inhibitors of coronavirus (COVID-19) main protease: an in silico study. Journal of biomolecular structure & dynamics. 2022 10; 40(17):8073-8084. doi: 10.1080/07391102.2021.1906749. [PMID: 33970805]
  • Qing Zhang, Die Qian, Dan-Dan Tang, Jia Liu, Lin-Yu Wang, Wenwen Chen, Chun-Jie Wu, Wei Peng. Glabridin from Glycyrrhiza glabra Possesses a Therapeutic Role against Keloid via Attenuating PI3K/Akt and Transforming Growth Factor-β1/SMAD Signaling Pathways. Journal of agricultural and food chemistry. 2022 Sep; 70(35):10782-10793. doi: 10.1021/acs.jafc.2c02045. [PMID: 36005946]
  • Shipra Bhatt, Ankita Sharma, Ashish Dogra, Priyanka Sharma, Amit Kumar, Pankul Kotwal, Swarnendu Bag, Prashant Misra, Gurdarshan Singh, Ajay Kumar, Payare Lal Sangwan, Utpal Nandi. Glabridin attenuates paracetamol-induced liver injury in mice via CYP2E1-mediated inhibition of oxidative stress. Drug and chemical toxicology. 2022 Sep; 45(5):2352-2360. doi: 10.1080/01480545.2021.1945004. [PMID: 34233566]
  • Hongtao Tan, Junxian Chen, Yicong Li, Yingshan Li, Yunchang Zhong, Guangzhao Li, Lingling Liu, Yiqun Li. Glabridin, a bioactive component of licorice, ameliorates diabetic nephropathy by regulating ferroptosis and the VEGF/Akt/ERK pathways. Molecular medicine (Cambridge, Mass.). 2022 05; 28(1):58. doi: 10.1186/s10020-022-00481-w. [PMID: 35596156]
  • Qingquan Guo, Shaojuan Wu, Wenyao Liang, Jianhua Tan, Xiangmei Liu, Yuxi Yuan, Xiaohong Li, Haishan Zhao. Glabrol impurity exacerbates glabridin toxicity in zebrafish embryos by increasing myofibril disorganization. Journal of ethnopharmacology. 2022 Apr; 287(?):114963. doi: 10.1016/j.jep.2021.114963. [PMID: 34971733]
  • Xier Pan, Yushu Li, Weilin Pang, Yaqi Xue, Zhuxian Wang, Cuiping Jiang, Chunyan Shen, Qiang Liu, Li Liu. Preparation, characterisation and comparison of glabridin-loaded hydrogel-forming microneedles by chemical and physical cross-linking. International journal of pharmaceutics. 2022 Apr; 617(?):121612. doi: 10.1016/j.ijpharm.2022.121612. [PMID: 35218899]
  • Mona H Haron, Bharathi Avula, Zulfiqar Ali, Amar G Chittiboyina, Ikhlas A Khan, Jing Li, Vivian Wang, Charles Wu, Shabana I Khan. Assessment of Herb-Drug Interaction Potential of Five Common Species of Licorice and Their Phytochemical Constituents. Journal of dietary supplements. 2022 Mar; ?(?):1-20. doi: 10.1080/19390211.2022.2050875. [PMID: 35302913]
  • Chen Xing, Wen-Qiang Cui, Yue Zhang, Xin-Shu Zou, Jing-You Hao, Si-Di Zheng, Ting-Ting Wang, Xiao-Zhen Wang, Tong Wu, Yan-Yan Liu, Xue-Ying Chen, Shu-Guang Yuan, Zhi-Yun Zhang, Yan-Hua Li. Ultrasound-assisted deep eutectic solvents extraction of glabridin and isoliquiritigenin from Glycyrrhiza glabra: Optimization, extraction mechanism and in vitro bioactivities. Ultrasonics sonochemistry. 2022 Feb; 83(?):105946. doi: 10.1016/j.ultsonch.2022.105946. [PMID: 35151194]
  • Tadayuki Tsukatani, Rieko Kuroda, Tomoaki Kawaguchi. Screening biofilm eradication activity of ethanol extracts from foodstuffs: potent biofilm eradication activity of glabridin, a major flavonoid from licorice (Glycyrrhiza glabra), alone and in combination with ɛ-poly-L-lysine. World journal of microbiology & biotechnology. 2022 Jan; 38(2):24. doi: 10.1007/s11274-021-03206-z. [PMID: 34989883]
  • Vigyasa Singh, Anirban Pal, Mahendra P Darokar. Glabridin synergy with norfloxacin induces ROS in multidrug resistant Staphylococcus aureus. The Journal of general and applied microbiology. 2021 Dec; 67(6):269-272. doi: 10.2323/jgam.2021.06.002. [PMID: 34690227]
  • Chunping Yang, Linjun Xie, Yuqing Ma, Xuewei Cai, Guizhou Yue, Guangwei Qin, Min Zhang, Guoshu Gong, Xiaoli Chang, Xiaoyan Qiu, Liya Luo, Huabao Chen. Study on the fungicidal mechanism of glabridin against Fusarium graminearum. Pesticide biochemistry and physiology. 2021 Nov; 179(?):104963. doi: 10.1016/j.pestbp.2021.104963. [PMID: 34802513]
  • Anping Li, Zhongmin Zhao, Shaoyong Zhang, Zhijun Zhang, Yanping Shi. Fungicidal Activity and Mechanism of Action of Glabridin from Glycyrrhiza glabra L. International journal of molecular sciences. 2021 Oct; 22(20):. doi: 10.3390/ijms222010966. [PMID: 34681623]
  • Jing Chang, Lin Wang, Minna Zhang, Zengjiao Lai. Glabridin attenuates atopic dermatitis progression through downregulating the TLR4/MyD88/NF-κB signaling pathway. Genes & genomics. 2021 08; 43(8):847-855. doi: 10.1007/s13258-021-01081-4. [PMID: 34021857]
  • Shipra Bhatt, Vinay Kumar, Ashish Dogra, Probir Kumar Ojha, Priya Wazir, Payare Lal Sangwan, Gurdarshan Singh, Utpal Nandi. Amalgamation of in-silico, in-vitro and in-vivo approach to establish glabridin as a potential CYP2E1 inhibitor. Xenobiotica; the fate of foreign compounds in biological systems. 2021 Jun; 51(6):625-635. doi: 10.1080/00498254.2021.1883769. [PMID: 33539218]
  • Muhammed Fatih Dogan, Ali Parlar, Saliha Aysenur Cam, Elif Merve Tosun, Fatma Uysal, Seyfullah Oktay Arslan. Glabridin attenuates airway inflammation and hyperresponsiveness in a mice model of ovalbumin-induced asthma. Pulmonary pharmacology & therapeutics. 2020 08; 63(?):101936. doi: 10.1016/j.pupt.2020.101936. [PMID: 32783990]
  • Yasukiyo Yoshioka, Yumi Samukawa, Yoko Yamashita, Hitoshi Ashida. 4-Hydroxyderricin and xanthoangelol isolated from Angelica keiskei prevent dexamethasone-induced muscle loss. Food & function. 2020 Jun; 11(6):5498-5512. doi: 10.1039/d0fo00720j. [PMID: 32510085]
  • Deepak Singh Kapkoti, Shilpi Singh, Sarfaraz Alam, Feroz Khan, Suaib Luqman, Rajendra Singh Bhakuni. In vitro antiproliferative activity of glabridin derivatives and their in silico target identification. Natural product research. 2020 Jun; 34(12):1735-1742. doi: 10.1080/14786419.2018.1530228. [PMID: 30580626]
  • Ali Parlar, Seyfullah Oktay Arslan, Saliha Ayşenur Çam. Glabridin Alleviates Inflammation and Nociception in Rodents by Activating BKCa Channels and Reducing NO Levels. Biological & pharmaceutical bulletin. 2020 May; 43(5):884-897. doi: 10.1248/bpb.b20-00038. [PMID: 32147624]
  • Lu-Jia Li, Guo-Wen Li, Yan Xie. [Regulatory effects of glabridin and quercetin on energy metabolism of breast cancer cells]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2019 Sep; 44(17):3786-3791. doi: 10.19540/j.cnki.cjcmm.20190505.401. [PMID: 31602954]
  • Jin Qian, Mengxin Xia, Wei Liu, Lujia Li, Jun Yang, Ye Mei, Qianchao Meng, Yan Xie. Glabridin resensitizes p-glycoprotein-overexpressing multidrug-resistant cancer cells to conventional chemotherapeutic agents. European journal of pharmacology. 2019 Jun; 852(?):231-243. doi: 10.1016/j.ejphar.2019.04.002. [PMID: 30959046]
  • Eun Mi Choi, Kwang Sik Suh, Woon-Won Jung, So Young Park, Sang Ouk Chin, Sang Youl Rhee, Youngmi Kim Pak, Suk Chon. Glabridin attenuates antiadipogenic activity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in murine 3T3-L1 adipocytes. Journal of applied toxicology : JAT. 2018 11; 38(11):1426-1436. doi: 10.1002/jat.3664. [PMID: 30051472]
  • Penghui Li, Yonglian Li, Hong Jiang, Yuting Xu, Xiaoying Liu, Biao Che, Jian Tang, Guangrong Liu, Yadong Tang, Wei Zhou, Langyue Zhang, Changzhi Dong, Huixiong Chen, Kun Zhang, Zhiyun Du. Glabridin, an isoflavan from licorice root, ameliorates imiquimod-induced psoriasis-like inflammation of BALB/c mice. International immunopharmacology. 2018 Jun; 59(?):243-251. doi: 10.1016/j.intimp.2018.04.018. [PMID: 29665498]
  • Yan Wang, Mi-Mi Hao, Ying Sun, Li-Feng Wang, Hao Wang, Yan-Jun Zhang, Hong-Yan Li, Peng-Wei Zhuang, Zhen Yang. Synergistic Promotion on Tyrosinase Inhibition by Antioxidants. Molecules (Basel, Switzerland). 2018 Jan; 23(1):. doi: 10.3390/molecules23010106. [PMID: 29300356]
  • Yi Kuang, Bin Li, Jingran Fan, Xue Qiao, Min Ye. Antitussive and expectorant activities of licorice and its major compounds. Bioorganic & medicinal chemistry. 2018 01; 26(1):278-284. doi: 10.1016/j.bmc.2017.11.046. [PMID: 29224994]
  • Rajni Sharma, Linda Gatchie, Ibidapo S Williams, Shreyans K Jain, Ram A Vishwakarma, Bhabatosh Chaudhuri, Sandip B Bharate. Glycyrrhiza glabra extract and quercetin reverses cisplatin resistance in triple-negative MDA-MB-468 breast cancer cells via inhibition of cytochrome P450 1B1 enzyme. Bioorganic & medicinal chemistry letters. 2017 12; 27(24):5400-5403. doi: 10.1016/j.bmcl.2017.11.013. [PMID: 29150398]
  • Yan Lin, Yi Kuang, Kai Li, Shuang Wang, Shuai Ji, Kuan Chen, Wei Song, Xue Qiao, Min Ye. Nrf2 activators from Glycyrrhiza inflata and their hepatoprotective activities against CCl4-induced liver injury in mice. Bioorganic & medicinal chemistry. 2017 10; 25(20):5522-5530. doi: 10.1016/j.bmc.2017.08.018. [PMID: 28835349]
  • Kaiqin Liu, Fuwei Pi, Hongxia Zhang, Jian Ji, Shuang Xia, Fangchao Cui, Jiadi Sun, Xiulan Sun. Metabolomics Analysis To Evaluate the Anti-Inflammatory Effects of Polyphenols: Glabridin Reversed Metabolism Change Caused by LPS in RAW 264.7 Cells. Journal of agricultural and food chemistry. 2017 Jul; 65(29):6070-6079. doi: 10.1021/acs.jafc.7b01692. [PMID: 28644019]
  • Yan Lin, Yi Kuang, Kai Li, Shuang Wang, Wei Song, Xue Qiao, Gulnar Sabir, Min Ye. Screening for bioactive natural products from a 67-compound library of Glycyrrhiza inflata. Bioorganic & medicinal chemistry. 2017 07; 25(14):3706-3713. doi: 10.1016/j.bmc.2017.05.009. [PMID: 28522265]
  • Y Zhao, Z N Lu. [Glabridin attenuates MPTP-induced parkinson disease by inhibiting extracellular regulated protein kinases signaling pathway]. Zhonghua yi xue za zhi. 2017 Jul; 97(26):2050-2054. doi: 10.3760/cma.j.issn.0376-2491.2017.26.008. [PMID: 28763878]
  • Ankita Singh Chakotiya, Ankit Tanwar, Pranay Srivastava, Alka Narula, Rakesh Kumar Sharma. Effect of aquo-alchoholic extract of Glycyrrhiza glabra against Pseudomonas aeruginosa in Mice Lung Infection Model. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2017 Jun; 90(?):171-178. doi: 10.1016/j.biopha.2017.03.055. [PMID: 28355591]
  • Li-Peng Zhang, Yan Zhao, Guo-Juan Liu, Da-Gang Yang, Yi-Huan Dong, Li-Hua Zhou. Glabridin attenuates lipopolysaccharide-induced acute lung injury by inhibiting p38MAPK/ERK signaling pathway. Oncotarget. 2017 Mar; 8(12):18935-18942. doi: 10.18632/oncotarget.14277. [PMID: 28039487]
  • Kai Li, Shuai Ji, Wei Song, Yi Kuang, Yan Lin, Shunan Tang, Zexu Cui, Xue Qiao, Siwang Yu, Min Ye. Glycybridins A-K, Bioactive Phenolic Compounds from Glycyrrhiza glabra. Journal of natural products. 2017 02; 80(2):334-346. doi: 10.1021/acs.jnatprod.6b00783. [PMID: 28140583]
  • L P Zhang, J G Li. [Glabridin reduces lipopolysaccharide-induced lung injury in rats by inhibiting p38 mitogen activated protein kinase/extracellular regulated protein kinases signaling pathway]. Zhonghua yi xue za zhi. 2016 Dec; 96(48):3893-3897. doi: 10.3760/cma.j.issn.0376-2491.2016.48.009. [PMID: 28057160]
  • Debrabata Chanda, Jesus Prieto-Lloret, Arjun Singh, Hina Iqbal, Pankaj Yadav, Vladimir Snetkov, Philip I Aaronson. Glabridin-induced vasorelaxation: Evidence for a role of BKCa channels and cyclic GMP. Life sciences. 2016 Nov; 165(?):26-34. doi: 10.1016/j.lfs.2016.09.018. [PMID: 27686831]
  • Jianmin Chen, Xiaojing Yu, Yufeng Huang. Inhibitory mechanisms of glabridin on tyrosinase. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2016 Nov; 168(?):111-117. doi: 10.1016/j.saa.2016.06.008. [PMID: 27288962]
  • Ming-Ju Hsieh, Mu-Kuan Chen, Chih-Jung Chen, Ming-Chang Hsieh, Yu-Sheng Lo, Yi-Ching Chuang, Hui-Ling Chiou, Shun-Fa Yang. Glabridin induces apoptosis and autophagy through JNK1/2 pathway in human hepatoma cells. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2016 Apr; 23(4):359-66. doi: 10.1016/j.phymed.2016.01.005. [PMID: 27002406]
  • Sylwia Klasik-Ciszewska, Ilona Kaczmarczyk-Sedlak, Weronika Wojnar. EFFECT OF GLABRIDIN AND GLYCYRRHIZIC ACID ON HISTOMORPHOMETRIC PARAMETERS OF BONES IN OVARIECTOMIZED RATS. Acta poloniae pharmaceutica. 2016 Mar; 73(2):517-27. doi: . [PMID: 27180445]
  • Vivek Viswanathan, Alka P Mukne. Development and Validation of HPLC and HPTLC Methods for Estimation of Glabridin in Extracts of Glycyrrhiza glabra. Journal of AOAC International. 2016 Mar; 99(2):374-9. doi: 10.5740/jaoacint.15-0239. [PMID: 27103104]
  • Shuai Ji, Ziwei Li, Wei Song, Yongrui Wang, Wenfei Liang, Kai Li, Shunan Tang, Qi Wang, Xue Qiao, Demin Zhou, Siwang Yu, Min Ye. Bioactive Constituents of Glycyrrhiza uralensis (Licorice): Discovery of the Effective Components of a Traditional Herbal Medicine. Journal of natural products. 2016 Feb; 79(2):281-92. doi: 10.1021/acs.jnatprod.5b00877. [PMID: 26841168]
  • Itamar Yehuda, Zecharia Madar, Alicia Leikin-Frenkel, Andrea Szuchman-Sapir, Faiga Magzal, Gilad Markman, Snait Tamir. Glabridin, an isoflavan from licorice root, upregulates paraoxonase 2 expression under hyperglycemia and protects it from oxidation. Molecular nutrition & food research. 2016 Feb; 60(2):287-99. doi: 10.1002/mnfr.201500441. [PMID: 26455358]
  • Dana Atrahimovich, Soliman Khatib, Shifra Sela, Jacob Vaya, Abraham O Samson. Punicalagin Induces Serum Low-Density Lipoprotein Influx to Macrophages. Oxidative medicine and cellular longevity. 2016; 2016(?):7124251. doi: 10.1155/2016/7124251. [PMID: 27516832]
  • John F Rebhun, Kelly M Glynn, Stephen R Missler. Identification of glabridin as a bioactive compound in licorice (Glycyrrhiza glabra L.) extract that activates human peroxisome proliferator-activated receptor gamma (PPARγ). Fitoterapia. 2015 Oct; 106(?):55-61. doi: 10.1016/j.fitote.2015.08.004. [PMID: 26297329]
  • Vigyasa Singh, Anirban Pal, Mahendra P Darokar. A polyphenolic flavonoid glabridin: Oxidative stress response in multidrug-resistant Staphylococcus aureus. Free radical biology & medicine. 2015 Oct; 87(?):48-57. doi: 10.1016/j.freeradbiomed.2015.06.016. [PMID: 26117328]
  • Itamar Yehuda, Zecharia Madar, Alicia Leikin-Frenkel, Snait Tamir. Glabridin, an isoflavan from licorice root, downregulates iNOS expression and activity under high-glucose stress and inflammation. Molecular nutrition & food research. 2015 Jun; 59(6):1041-52. doi: 10.1002/mnfr.201400876. [PMID: 25737160]
  • Atsuko Tada, Kyoko Ishizuki, Naoki Sugimoto, Kayo Yoshimatsu, Nobuo Kawahara, Takako Suematsu, Kazunori Arifuku, Toshio Fukai, Yukiyoshi Tamura, Takashi Ohtsuki, Maiko Tahara, Takeshi Yamazaki, Hiroshi Akiyama. [Determination of the Plant Origin of Licorice Oil Extract, a Natural Food Additive, by Principal Component Analysis Based on Chemical Components]. Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan. 2015; 56(5):217-27. doi: 10.3358/shokueishi.56.217. [PMID: 26537652]
  • Lingxiao Chen, Wenhua Ji, Wenjuan Duan, Xiao Wang, Qianshan Gao, Yanling Geng, Luqi Huang. Effectively designed molecularly imprinted polymers for selective extraction of glabridin from Glycyrrhiza glabra L. residues by screening the library of non-imprinted polymers. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2014 Aug; 965(?):1-6. doi: 10.1016/j.jchromb.2014.05.052. [PMID: 24973770]
  • Keisuke Sawada, Yoko Yamashita, Tianshun Zhang, Kaku Nakagawa, Hitoshi Ashida. Glabridin induces glucose uptake via the AMP-activated protein kinase pathway in muscle cells. Molecular and cellular endocrinology. 2014 Aug; 393(1-2):99-108. doi: 10.1016/j.mce.2014.06.009. [PMID: 24953974]
  • Myrna Adianti, Chie Aoki, Mari Komoto, Lin Deng, Ikuo Shoji, Tutik Sri Wahyuni, Maria Inge Lusida, Soetjipto, Hiroyuki Fuchino, Nobuo Kawahara, Hak Hotta. Anti-hepatitis C virus compounds obtained from Glycyrrhiza uralensis and other Glycyrrhiza species. Microbiology and immunology. 2014 Mar; 58(3):180-7. doi: 10.1111/1348-0421.12127. [PMID: 24397541]
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