1H-Indole-2,3-dione (BioDeep_00000003332)

 

Secondary id: BioDeep_00000858436

human metabolite PANOMIX_OTCML-2023


代谢物信息卡片


Indoline-2,3-dione;2,3-Dioxo-2,3-dihydroindole; Isatic acid lactam; Isotin

化学式: C8H5NO2 (147.032)
中文名称: 吲哚-2,3-二酮, 靛红
谱图信息: 最多检出来源 Homo sapiens(blood) 6.08%

分子结构信息

SMILES: C1=CC=C2C(=C1)C(=O)C(=O)N2
InChI: InChI=1S/C8H5NO2/c10-7-5-3-1-2-4-6(5)9-8(7)11/h1-4H,(H,9,10,11)

描述信息

Isatin is an indoledione that is the 2,3-diketo derivative of indole. It has a role as an EC 1.4.3.4 (monoamine oxidase) inhibitor and a plant metabolite.
Isatin is an indole derivative first obtained by Erdman and Laurent in 1841 as an oxidation product of Indigo dye with nitric acid and chromic acids. The compound is found in many plants and Schiff bases of Isatin are have been investigated for pharmaceutical applications.
Isatin is a natural product found in Isatis tinctoria, Alteromonas, and other organisms with data available.
An indole-dione that is obtained by oxidation of indigo blue. It is a MONOAMINE OXIDASE INHIBITOR and high levels have been found in urine of PARKINSONISM patients.
1H-Indole-2,3-dione belongs to the class of organic compounds known as indolines. These are compounds containing an indole moiety, which consists of pyrrolidine ring fused to benzene to form 2,3-dihydroindole.
An indoledione that is the 2,3-diketo derivative of indole.
COVID info from PDB, Protein Data Bank
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
[Raw Data] CB237_Isatin_pos_20eV_rep000005.txt
[Raw Data] CB237_Isatin_pos_50eV_rep000005.txt
[Raw Data] CB237_Isatin_pos_30eV_rep000005.txt
[Raw Data] CB237_Isatin_pos_40eV_rep000005.txt
[Raw Data] CB237_Isatin_pos_10eV_rep000005.txt
KEIO_ID I019
Isatin (Indoline-2,3-dione) is a potent inhibitor of monoamine oxidase (MAO) with an IC50 of 3 μM. Also binds to central benzodiazepine receptors (IC50 against clonazepam, 123 μM)[1]. Also acts as an antagonist of both atrial natriuretic peptide stimulated and nitric oxide-stimulated guanylate cyclase activity[2]. Shows effect on the serotonergic system[3].
Isatin (Indoline-2,3-dione) is a potent inhibitor of monoamine oxidase (MAO) with an IC50 of 3 μM. Also binds to central benzodiazepine receptors (IC50 against clonazepam, 123 μM)[1]. Also acts as an antagonist of both atrial natriuretic peptide stimulated and nitric oxide-stimulated guanylate cyclase activity[2]. Shows effect on the serotonergic system[3].

同义名列表

45 个代谢物同义名

Indoline-2,3-dione;2,3-Dioxo-2,3-dihydroindole; Isatic acid lactam; Isotin; Isatin, for spectrophotometric det. of proline and thiophene, >=99.0\\%; InChI=1/C8H5NO2/c10-7-5-3-1-2-4-6(5)9-8(7)11/h1-4H,(H,9,10,11; 5-21-10-00221 (Beilstein Handbook Reference); (R)-3-Hydroxymethylmorpholine hydrochloride; 2,3-dihydro-1H-indole-2,3-dione; 2,3-dihydro-1H-indol-2,3-dione; o-Aminobenzoylformic anhydride; 2,3-Dihydro-indole-2,3-dione; 2,3-dihydroindole-2,3-dione; 2,3-Dioxo-2,3-dihydroindole; Isatin, technical grade; Isatinic acid anhydride; 3-hydroxy-2-indolone; 1H-Indole-2,3-dione; Isatin (Compound 1); 2H-indole-2,3-dione; hydroxy-3-indolone; Isatic acid lactam; Indoline-2,3-dione; 2,3-Diketoindoline; 2,3-Indolinedione; 2,3 Dioxoindoline; 2,3-Dioxoindoline; 2,3-Ketoindoline; INDOLE-2,3-DIONE; UNII-82X95S7M06; 3-Indolinedione; WLN: T56 BMVVJ; ISATIN [INCI]; Tox21_202876; Pseudoisatin; Isatin, p.a.; CAS-91-56-5; ISATIN [MI]; 82X95S7M06; AI3-03111; Indole-2; Tribulin; indol-2; Isatine; Isatin; Isotin; Isatin; Isatin



数据库引用编号

39 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(0)

代谢反应

1 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(1)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

8 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 13 AKT1, ANXA5, BCL2, CASP3, CDK1, EGFR, GAPDH, MSMP, NPPA, PTGS2, SGCB, TP53, TUBB4B
Peripheral membrane protein 3 ACHE, ANXA5, PTGS2
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 4 BCL2, CDK1, EGFR, PTGS2
Mitochondrion membrane 1 MAOA
Nucleus 9 ACHE, AKT1, BCL2, CASP3, CDK1, EGFR, GAPDH, TP53, TUBB4B
cytosol 9 AKT1, ANXA5, BCL2, CASP3, CDK1, GAPDH, MAOA, TP53, TUBB4B
dendrite 1 MAOB
centrosome 2 CDK1, TP53
nucleoplasm 4 AKT1, CASP3, CDK1, TP53
Cell membrane 5 ACHE, AKT1, EGFR, PROKR2, TNF
Cytoplasmic side 2 MAOA, MAOB
lamellipodium 1 AKT1
ruffle membrane 1 EGFR
Early endosome membrane 1 EGFR
Multi-pass membrane protein 1 PROKR2
Synapse 1 ACHE
cell cortex 1 AKT1
cell junction 1 EGFR
cell surface 3 ACHE, EGFR, TNF
glutamatergic synapse 3 AKT1, CASP3, EGFR
Golgi apparatus 1 ACHE
Golgi membrane 1 EGFR
lysosomal membrane 1 GAA
neuromuscular junction 1 ACHE
neuronal cell body 3 CASP3, MAOB, TNF
postsynapse 1 AKT1
sarcolemma 2 ANXA5, SGCB
Cytoplasm, cytosol 1 GAPDH
Lysosome 1 GAA
endosome 1 EGFR
plasma membrane 9 ACHE, AKT1, BCHE, EGFR, GAA, GAPDH, PROKR2, SGCB, TNF
Membrane 10 ACHE, AKT1, ANXA5, BCL2, CDK1, EGFR, GAA, GAPDH, MAOA, TP53
apical plasma membrane 1 EGFR
basolateral plasma membrane 1 EGFR
caveola 1 PTGS2
extracellular exosome 5 ANXA5, CDK1, GAA, GAPDH, TUBB4B
Lysosome membrane 1 GAA
endoplasmic reticulum 3 BCL2, PTGS2, TP53
extracellular space 6 ACHE, BCHE, EGFR, MSMP, NPPA, TNF
lysosomal lumen 1 GAA
perinuclear region of cytoplasm 3 ACHE, EGFR, GAPDH
mitochondrion 5 BCL2, CDK1, MAOA, MAOB, TP53
protein-containing complex 6 AKT1, BCL2, EGFR, NPPA, PTGS2, TP53
intracellular membrane-bounded organelle 2 GAA, GAPDH
Microsome membrane 1 PTGS2
postsynaptic density 1 CASP3
Single-pass type I membrane protein 1 EGFR
Secreted 5 ACHE, BCHE, GAA, MSMP, NPPA
extracellular region 7 ACHE, ANXA5, BCHE, GAA, NPPA, TNF, TUBB4B
Mitochondrion outer membrane 3 BCL2, MAOA, MAOB
Single-pass membrane protein 2 BCL2, MAOA
mitochondrial outer membrane 3 BCL2, MAOA, MAOB
Mitochondrion matrix 1 TP53
mitochondrial matrix 2 CDK1, TP53
Extracellular side 1 ACHE
transcription regulator complex 1 TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 2 CDK1, TP53
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 3 BCL2, EGFR, GAPDH
external side of plasma membrane 2 ANXA5, TNF
Extracellular vesicle 1 TUBB4B
perikaryon 1 NPPA
microtubule cytoskeleton 3 AKT1, GAPDH, TUBB4B
nucleolus 1 TP53
midbody 1 CDK1
cell-cell junction 1 AKT1
recycling endosome 1 TNF
Single-pass type II membrane protein 2 SGCB, TNF
vesicle 2 AKT1, GAPDH
Cell membrane, sarcolemma 1 SGCB
Cytoplasm, perinuclear region 1 GAPDH
Membrane raft 2 EGFR, TNF
pore complex 1 BCL2
Cytoplasm, cytoskeleton 4 GAPDH, SGCB, TP53, TUBB4B
focal adhesion 2 ANXA5, EGFR
microtubule 1 TUBB4B
spindle 1 AKT1
basement membrane 1 ACHE
intracellular vesicle 1 EGFR
Nucleus, PML body 1 TP53
PML body 1 TP53
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 2 ANXA5, NPPA
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
receptor complex 1 EGFR
Zymogen granule membrane 1 ANXA5
neuron projection 1 PTGS2
ciliary basal body 1 AKT1
chromatin 1 TP53
cell projection 1 NPPA
phagocytic cup 1 TNF
mitotic spindle 2 CDK1, TUBB4B
cytoskeleton 3 GAPDH, SGCB, TUBB4B
chromosome, telomeric region 1 CDK1
blood microparticle 1 BCHE
Lipid-anchor, GPI-anchor 1 ACHE
site of double-strand break 1 TP53
intercellular bridge 1 TUBB4B
Cytoplasm, cytoskeleton, flagellum axoneme 1 TUBB4B
sperm flagellum 1 TUBB4B
Lipid droplet 1 GAPDH
axonemal microtubule 1 TUBB4B
tertiary granule membrane 1 GAA
side of membrane 1 ACHE
germ cell nucleus 1 TP53
replication fork 1 TP53
myelin sheath 1 BCL2
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
endoplasmic reticulum lumen 2 BCHE, PTGS2
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
azurophil granule membrane 1 GAA
azurophil granule lumen 1 TUBB4B
mitochondrial envelope 1 MAOB
Single-pass type IV membrane protein 2 MAOA, MAOB
nuclear envelope lumen 1 BCHE
vesicle membrane 1 ANXA5
clathrin-coated endocytic vesicle membrane 1 EGFR
ribonucleoprotein complex 1 GAPDH
[Isoform 1]: Nucleus 1 TP53
synaptic cleft 1 ACHE
ficolin-1-rich granule membrane 1 GAA
spindle microtubule 1 CDK1
death-inducing signaling complex 1 CASP3
dystrophin-associated glycoprotein complex 1 SGCB
sarcoglycan complex 1 SGCB
GAIT complex 1 GAPDH
cyclin-dependent protein kinase holoenzyme complex 1 CDK1
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
[Long-acting natriuretic peptide]: Secreted 1 NPPA
[Vessel dilator]: Secreted 1 NPPA
[Kaliuretic peptide]: Secreted 1 NPPA
[Urodilatin]: Secreted 1 NPPA
[Atrial natriuretic peptide]: Secreted 1 NPPA
[Atriopeptin-3]: Secreted 1 NPPA
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
cyclin A1-CDK1 complex 1 CDK1
cyclin A2-CDK1 complex 1 CDK1
cyclin B1-CDK1 complex 1 CDK1
endothelial microparticle 1 ANXA5
autolysosome lumen 1 GAA
BAD-BCL-2 complex 1 BCL2
[Isoform H]: Cell membrane 1 ACHE
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Mohammad Altamimi, Saeed Ali Syed, Burak Tuzun, Mohammad Rashid Alhazani, Osamah Alnemer, Ahmed Bari. Synthesis biological evaluation and molecular docking of isatin hybrids as anti-cancer and anti-microbial agents. Journal of enzyme inhibition and medicinal chemistry. 2024 Dec; 39(1):2288548. doi: 10.1080/14756366.2023.2288548. [PMID: 38073431]
  • Heba E Saad, Gaber M Abu El-Reash, Mohamed Gaber, Mohamed A Hashem, Yasmeen G Abou El-Reash, Nuha Y Elamin, Mohamed R Elamin, Yusif S El-Sayed. A novel isatin Schiff based cerium complex: synthesis, characterization, antimicrobial activity and molecular docking studies. BMC genomics. 2024 Feb; 25(1):162. doi: 10.1186/s12864-024-10037-3. [PMID: 38331729]
  • Weihuan Zeng, Jun Qian, Yue Wang, Minyu Shou, Guoyin Kai. Bletilla Striata polysaccharides thermosensitive gel for photothermal treatment of bacterial infection. International journal of biological macromolecules. 2023 Oct; ?(?):127430. doi: 10.1016/j.ijbiomac.2023.127430. [PMID: 37838114]
  • Andrei V Bogdanov, Margarita Neganova, Alexandra Voloshina, Anna Lyubina, Syumbelya Amerhanova, Igor A Litvinov, Olga Tsivileva, Nurgali Akylbekov, Rakhmetulla Zhapparbergenov, Zulfiia Valiullina, Alexandr V Samorodov, Igor Alabugin. Anticancer and Antiphytopathogenic Activity of Fluorinated Isatins and Their Water-Soluble Hydrazone Derivatives. International journal of molecular sciences. 2023 Oct; 24(20):. doi: 10.3390/ijms242015119. [PMID: 37894799]
  • Shaohuan Liu, Shu Wang, Dan Xu, Bowen Pan, Linzhi Chen, Shijia Zhao, Zhi Xu, Wei Zhou. Novel ester tethered dihydroartemisinin-3-(oxime/thiosemicarbazide)isatin hybrids as potential anti-breast cancer agents: Synthesis, in vitro cytotoxicity and structure-activity relationship. Drug development research. 2023 May; ?(?):. doi: 10.1002/ddr.22078. [PMID: 37165798]
  • Zhi Xu, Bowen Pan, Linzhi Chen, Dan Xu. Design, synthesis, and in vitro cytotoxicity evaluation of novel dihydroartemisinin-isatin hybrids tethered via different length of esters as potential anti-breast cancer agents. Fitoterapia. 2023 Apr; 166(?):105436. doi: 10.1016/j.fitote.2023.105436. [PMID: 36693438]
  • Zhi Xu, Xiaoyan Zhang, Jie Liu, Shijia Zhao, Junna Liu, Wei Zhou. Design, Synthesis, and Biological Evaluation of Novel Amyl Ester Tethered Dihydroartemisinin-Isatin Hybrids as Potent Anti-Breast Cancer Agents. Chemistry & biodiversity. 2023 Mar; 20(3):e202201257. doi: 10.1002/cbdv.202201257. [PMID: 36808231]
  • Vishnu Nayak Badavath, Akhil Kumar, Pralok K Samanta, Siddhartha Maji, Anik Das, Galia Blum, Anjali Jha, Anik Sen. Determination of potential inhibitors based on isatin derivatives against SARS-CoV-2 main protease (mpro): a molecular docking, molecular dynamics and structure-activity relationship studies. Journal of biomolecular structure & dynamics. 2022 04; 40(7):3110-3128. doi: 10.1080/07391102.2020.1845800. [PMID: 33200681]
  • Nasima Arshad, Muhammad Ismail Mir, Fouzia Perveen, Aneela Javed, Memona Javaid, Aamer Saeed, Pervaiz Ali Channar, Shahid Iqbal Farooqi, Saad Alkahtani, Jamshed Anwar. Investigations on Anticancer Potentials by DNA Binding and Cytotoxicity Studies for Newly Synthesized and Characterized Imidazolidine and Thiazolidine-Based Isatin Derivatives. Molecules (Basel, Switzerland). 2022 Jan; 27(2):. doi: 10.3390/molecules27020354. [PMID: 35056668]
  • Divya Utreja, Komalpreet Kaur, Narpinderjeet K Dhillon, Rajesh K Pathak. 3-Hydroxy-3-alkylindolin-2-ones: regioselective synthesis, molecular docking and nematicidal studies against Meloidogyne incognita. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. 2022; 57(8):657-669. doi: 10.1080/03601234.2022.2097504. [PMID: 35930393]
  • Matt D Johansen, Shalini, Sumit Kumar, Clément Raynaud, Diana H Quan, Warwick J Britton, Philip M Hansbro, Vipan Kumar, Laurent Kremer. Biological and Biochemical Evaluation of Isatin-Isoniazid Hybrids as Bactericidal Candidates against Mycobacterium tuberculosis. Antimicrobial agents and chemotherapy. 2021 07; 65(8):e0001121. doi: 10.1128/aac.00011-21. [PMID: 33972252]
  • Paul Awolade, Nosipho Cele, Oluwakemi Ebenezer, Nagaraju Kerru, Lalitha Gummidi, Liang Gu, Gabriella Palma, Mandeep Kaur, Parvesh Singh. Synthesis of 1H-1,2,3-Triazole-Linked Quinoline-Isatin Molecular Hybrids as Anti-Breast Cancer and Anti-Methicillin-Resistant Staphylococcus aureus (MRSA) Agents. Anti-cancer agents in medicinal chemistry. 2021; 21(10):1228-1239. doi: 10.2174/1871520620666200929153138. [PMID: 32990543]
  • Konda Swathi, K Sowjanya, Lavanya Sara, P Naveena. Design, Characterization, and Docking Studies of Some Novel Isatin Derivatives for Anticonvulsant and Antidepressant Activity. Advances in experimental medicine and biology. 2021; 1339(?):359-369. doi: 10.1007/978-3-030-78787-5_44. [PMID: 35023126]
  • Komalpreet Kaur, Divya Utreja, Narpinderjeet K Dhillon, Rajesh K Pathak, Kamaljit Singh. N-alkyl isatin derivatives: Synthesis, nematicidal evaluation and protein target identifications for their mode of action. Pesticide biochemistry and physiology. 2021 Jan; 171(?):104736. doi: 10.1016/j.pestbp.2020.104736. [PMID: 33357558]
  • Pei Liu, Hongbo Liu, Qi Sun, Hao Liang, Chunmei Li, Xiaobing Deng, Ying Liu, Luhua Lai. Potent inhibitors of SARS-CoV-2 3C-like protease derived from N-substituted isatin compounds. European journal of medicinal chemistry. 2020 Nov; 206(?):112702. doi: 10.1016/j.ejmech.2020.112702. [PMID: 32798789]
  • Anne Suély Pinto Savall, Eduarda Monteiro Fidélis, Maria Eduarda Ziani Gutierrez, Bianca Barreto Martins, Vanessa Carratú Gervini, Robson Luiz Puntel, Daniel Henrique Roos, Daiana Silva Ávila, Simone Pinton. Pre-clinical evidence of safety and protective effect of isatin and oxime derivatives against malathion-induced toxicity. Basic & clinical pharmacology & toxicology. 2020 Apr; 126(4):399-410. doi: 10.1111/bcpt.13359. [PMID: 31694074]
  • Yong Wang, Wing-Lam Cheong, Zhiguang Liang, Lok-Yan So, Kin-Fai Chan, Pui-Kin So, Yu Wai Chen, Wing-Leung Wong, Kwok-Yin Wong. Hydrophobic substituents on isatin derivatives enhance their inhibition against bacterial peptidoglycan glycosyltransferase activity. Bioorganic chemistry. 2020 04; 97(?):103710. doi: 10.1016/j.bioorg.2020.103710. [PMID: 32146179]
  • Ya-Zhou Zhang, Hong-Zhi Du, Hai-Lin Liu, Qian-Song He, Zhi Xu. Isatin dimers and their biological activities. Archiv der Pharmazie. 2020 Mar; 353(3):e1900299. doi: 10.1002/ardp.201900299. [PMID: 31985855]
  • Mingli Yang, Hailin Liu, Yazhou Zhang, Xiujun Wang, Zhi Xu. Moxifloxacin-isatin Hybrids Tethered by 1,2,3-triazole and their Anticancer Activities. Current topics in medicinal chemistry. 2020; 20(16):1461-1467. doi: 10.2174/1568026620666200128144825. [PMID: 31994464]
  • L L S F R Dantas, A G Fonseca, J R Pereira, A A Furtado, P A T M Gomes, M F Fernandes-Pedrosa, A C L Leite, M J B M Rêgo, M G R Pitta, T M A M Lemos. Anti-inflammatory and antinociceptive effects of the isatin derivative (Z)-2-(5-chloro-2-oxoindolin-3-ylidene)-N-phenyl-hydrazinecarbothioamide in mice. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. 2020; 53(10):e10204. doi: 10.1590/1414-431x202010204. [PMID: 32901685]
  • Govindasami Periyasami, Paulrayer Antonisamy, Karthikeyan Perumal, Antony Stalin, Mostafizur Rahaman, Asma A Alothman. A competent synthesis and efficient anti-inflammatory responses of isatinimino acridinedione moiety via suppression of in vivo NF-κB, COX-2 and iNOS signaling. Bioorganic chemistry. 2019 09; 90(?):103047. doi: 10.1016/j.bioorg.2019.103047. [PMID: 31234130]
  • Sara Zeeshan, Muhammad Naveed, Adnan Khan, Ayesha Atiq, Maryam Arif, Muhammad Naeem Ahmed, Yeong Shik Kim, Salman Khan. N-Pyrazoloyl and N-thiopheneacetyl hydrazone of isatin exhibited potent anti-inflammatory and anti-nociceptive properties through suppression of NF-κB, MAPK and oxidative stress signaling in animal models of inflammation. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 2019 Jul; 68(7):613-632. doi: 10.1007/s00011-019-01245-9. [PMID: 31079165]
  • Satoshi Endo, Namiki Miyagi, Toshiyuki Matsunaga, Akira Ikari. Rabbit dehydrogenase/reductase SDR family member 11 (DHRS11): Its identity with acetohexamide reductase with broad substrate specificity and inhibitor sensitivity, different from human DHRS11. Chemico-biological interactions. 2019 May; 305(?):12-20. doi: 10.1016/j.cbi.2019.03.026. [PMID: 30926317]
  • Babita Aneja, Nashrah Sharif Khan, Parvez Khan, Aarfa Queen, Afzal Hussain, Md Tabish Rehman, Mohamed F Alajmi, Hesham R El-Seedi, Sher Ali, Md Imtaiyaz Hassan, Mohammad Abid. Design and development of Isatin-triazole hydrazones as potential inhibitors of microtubule affinity-regulating kinase 4 for the therapeutic management of cell proliferation and metastasis. European journal of medicinal chemistry. 2019 Feb; 163(?):840-852. doi: 10.1016/j.ejmech.2018.12.026. [PMID: 30579124]
  • Wenyan Gao, Luding Zhang, Xiaoqian Wang, Li Yu, Changhong Wang, Yang Gong. The combination of indirubin and isatin attenuates dextran sodium sulfate induced ulcerative colitis in mice. Biochemistry and cell biology = Biochimie et biologie cellulaire. 2018 10; 96(5):636-645. doi: 10.1139/bcb-2018-0041. [PMID: 29671340]
  • Qiaomei Jin, Jian Zhang, Cuihua Jiang, Dongjian Zhang, Meng Gao, Shihe Hu. Self [3 + 4] Cycloadditions of Isatin N, N'-Cyclic Azomethine Imine 1,3-Dipole with N-( o-Chloromethyl)aryl Amides. The Journal of organic chemistry. 2018 08; 83(15):8410-8416. doi: 10.1021/acs.joc.8b01055. [PMID: 29846070]
  • Xiaoze Bao, Shiqiang Wei, Xingkai Qian, Jingping Qu, Baomin Wang, Liwei Zou, Guangbo Ge. Asymmetric Construction of a Multi-Pharmacophore-Containing Dispirotriheterocyclic Scaffold and Identification of a Human Carboxylesterase 1 Inhibitor. Organic letters. 2018 06; 20(11):3394-3398. doi: 10.1021/acs.orglett.8b01316. [PMID: 29786435]
  • Anirban Ganguly, Hari Krishna Reddy Rachamalla, Dwaipayan Bhattacharya, Keerti Bhamidipati, Abhishek Pal, Halley Gora Ravuri, Sumana Chakravarty, Susanta Sekhar Adhikari, Rajkumar Banerjee. Oestrogen receptor-mediated liposomal drug delivery for treating melanoma. Journal of drug targeting. 2018 Jun; 26(5-6):481-493. doi: 10.1080/1061186x.2018.1433679. [PMID: 29376759]
  • Bence Szilágyi, Péter Kovács, György G Ferenczy, Anita Rácz, Krisztina Németh, Júlia Visy, Pál Szabó, Janez Ilas, György T Balogh, Katalin Monostory, István Vincze, Tamás Tábi, Éva Szökő, György M Keserű. Discovery of isatin and 1H-indazol-3-ol derivatives as d-amino acid oxidase (DAAO) inhibitors. Bioorganic & medicinal chemistry. 2018 05; 26(8):1579-1587. doi: 10.1016/j.bmc.2018.02.004. [PMID: 29472125]
  • Mary Ensch, Vanessa Y Maldonado, Greg M Swain, Robert Rechenberg, Michael F Becker, Thomas Schuelke, Cory A Rusinek. Isatin Detection Using a Boron-Doped Diamond 3-in-1 Sensing Platform. Analytical chemistry. 2018 02; 90(3):1951-1958. doi: 10.1021/acs.analchem.7b04045. [PMID: 29298039]
  • Manoela Viar Fogaça, Priscila de Matos Cândido-Bacani, Lucas Milanez Benicio, Lara Martinelli Zapata, Priscilla de Freitas Cardoso, Marcelo Tempesta de Oliveira, Tamara Regina Calvo, Eliana Aparecida Varanda, Wagner Vilegas, Ilce Mara de Syllos Cólus. Effects of indirubin and isatin on cell viability, mutagenicity, genotoxicity and BAX/ERCC1 gene expression. Pharmaceutical biology. 2017 Dec; 55(1):2005-2014. doi: 10.1080/13880209.2017.1354387. [PMID: 28738722]
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