Sarsasapogenin (BioDeep_00000000033)

   

natural product human metabolite PANOMIX_OTCML-2023 Endogenous Chemicals and Drugs


代谢物信息卡片


(2aR,4S,5S,6aS,6bS,8aS,8bR,9S,10R,11aS,12aS,12bR)-5,6a,8a,9-tetramethyldocosahydrospiro[naphtho[2,1:4,5]indeno[2,1-b]furan-10,2-pyran]-4-ol

化学式: C27H44O3 (416.3290274)
中文名称: 菝葜皂苷元, 菝葜皂苷元
谱图信息: 最多检出来源 Viridiplantae(plant) 0.58%

分子结构信息

SMILES: C1[C@]2(C)[C@@]3([H])CC[C@]4(C)[C@H]5[C@@H]([C@]6(O[C@H]5C[C@@]4([H])[C@]3([H])CC[C@]2([H])C[C@@H](O)C1)CC[C@H](C)CO6)C
InChI: InChI=1/C27H44O3/c1-16-7-12-27(29-15-16)17(2)24-23(30-27)14-22-20-6-5-18-13-19(28)8-10-25(18,3)21(20)9-11-26(22,24)4/h16-24,28H,5-15H2,1-4H3/t16-,17-,18+,19-,20+,21-,22-,23-,24-,25-,26-,27+/m0/s1

描述信息

(25S)-5beta-spirostan-3beta-ol is a sapogenin.
Sarsasapogenin is a natural product found in Yucca gloriosa, Narthecium ossifragum, and other organisms with data available.
Constituent of Radix sarsaparilla (sarsaparilla root). Sarsasapogenin is found in asparagus, herbs and spices, and fenugreek.
Sarsasapogenin is found in asparagus. Sarsasapogenin is a constituent of Radix sarsaparilla (sarsaparilla root)
C274 - Antineoplastic Agent > C1931 - Antineoplastic Plant Product > C823 - Saponin
C1907 - Drug, Natural Product
Sarsasapogenin is a sapogenin from the Chinese medical herb Anemarrhena asphodeloides Bunge, with antidiabetic, anti-oxidative, anticancer and anti-inflamatory activities.
Sarsasapogenin is a sapogenin from the Chinese medical herb Anemarrhena asphodeloides Bunge, with antidiabetic, anti-oxidative, anticancer and anti-inflamatory activities.

同义名列表

50 个代谢物同义名

(2aR,4S,5S,6aS,6bS,8aS,8bR,9S,10R,11aS,12aS,12bR)-5,6a,8a,9-tetramethyldocosahydrospiro[naphtho[2,1:4,5]indeno[2,1-b]furan-10,2-pyran]-4-ol; (1R,2R,2S,4S,5S,7S,8R,9S,12S,13S,16S,18R)-5,7,9,13-tetramethyl-5-oxaspiro[oxane-2,6-pentacyclo[10.8.0.0?,?.0?,?.0??,??]icosane]-16-ol; (1R,2R,2S,4S,5S,7S,8R,9S,12S,13S,16S,18R)-5,7,9,13-tetramethyl-5-oxaspiro[oxane-2,6-pentacyclo[10.8.0.0²,⁹.0⁴,⁸.0¹³,¹⁸]icosane]-16-ol; (1R,2S,4S,5S,6R,7S,8R,9S,12S,13S,16S,18R)-5,7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icosane-6,2-oxane]-16-ol; sarsasapogenin, (3beta,5alpha,25S)-isomer; sarsasapogenin, (3beta,5alpha,25R)-isomer; Spirostan-3-ol, (3beta,5beta,25S)- (9CI); sarsasapogenin, (3beta,5beta,25S)-isomer; sarsasapogenin, (3beta,5beta,25R)-isomer; Spirostan-3-ol, (3.beta.,5.beta.,25S)-; sarsasapogenin, (3beta,5beta)-isomer; (3.BETA.,5.BETA.,25S)-SPIROSTAN-3-OL; Spirostan-3-ol, (3beta,5beta,25S)-; (25S)-5-beta-spirostan-3-beta-ol; (3beta,5beta,25S)-spirostan-3-ol; 5beta-Spirostan-3beta-ol, (25S)-; Spirostan-3-ol, (3ss,5ss,25S)-; (25S)-5beta-Spirostan-3beta-ol; Sarsapogenin (Sarsasapogenin); Spirostan-3-ol, (3b,5b,25S)-; GMBQZIIUCVWOCD-WWASVFFGSA-N; (3b,5b,25S)-Spirostan-3-ol; (3Β,5β,25S)-spirostan-3-ol; (25S)-5b-Spirostan-3b-ol; (25S)-5Β-spirostan-3β-ol; Sarsasapogenin, >=98\\%; SARSASAPOGENIN [INCI]; Sarsasapogenin, 95\\%; Parigenin;Sarsagenin; PURE SARSASAPOGENIN; SARSASAPOGENIN [MI]; epi-sarsasapogenin; Sarsagenin [INN]; Sarsasapogenenin; Sarsasapogenine; Sasarasapogenin; Sarsasapogenin; sarsasopogenin; epismilagenin; Sarsapogenine; sarsapogenin; Sarsagenin; smilagenin; ST 27:2;O3; sarsaponin; tigogenin; Parigenin; cogan; (25S)-5beta-Spirostan-3beta-ol;(25S)-5beta-spirostan-3beta-ol;(3beta,5beta,25S)-spirostan-3-ol; Spirostan-3-ol



数据库引用编号

25 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

146 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Shuangshuang Yang, Lei Fan, Rui Zhang, Chenghuan Song, Jiyun Shi, Jing Wang, Pingao Zhang, Hao Wang, Yongfang Zhang. Smilagenin induces expression and epigenetic remodeling of BDNF in alzheimer's disease. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Sep; 118(?):154956. doi: 10.1016/j.phymed.2023.154956. [PMID: 37499345]
  • Yuan Dai, Panwang Liu, Wen Wen, Ping Li, Chen Yang, Ping Wang, Shijun Xu. Sarsasapogenin, a principal active component absorbed into blood of total saponins of Anemarrhena, attenuates proliferation and invasion in rheumatoid arthritis fibroblast-like synoviocytes through downregulating PKM2 inhibited pathological glycolysis. Phytotherapy research : PTR. 2023 Jan; ?(?):. doi: 10.1002/ptr.7712. [PMID: 36631974]
  • Deepa S Mandlik, Satish K Mandlik, Snehal Patel. Protective effect of sarsasapogenin in TNBS induced ulcerative colitis in rats associated with downregulation of pro-inflammatory mediators and oxidative stress. Immunopharmacology and immunotoxicology. 2021 Oct; 43(5):571-583. doi: 10.1080/08923973.2021.1955919. [PMID: 34338577]
  • Xi-Zhi Li, Hong Jiang, Liu Xu, Yi-Qi Liu, Jia-Wei Tang, Jia-Sen Shi, Xiu-Juan Yu, Xue Wang, Lei Du, Qian Lu, Cheng-Lin Li, Yao-Wu Liu, Xiao-Xing Yin. Sarsasapogenin restores podocyte autophagy in diabetic nephropathy by targeting GSK3β signaling pathway. Biochemical pharmacology. 2021 10; 192(?):114675. doi: 10.1016/j.bcp.2021.114675. [PMID: 34252407]
  • Zuzana Bednarikova, Miroslav Gancar, Rui Wang, Lulu Zheng, Yun Tang, Yating Luo, Yan Huang, Barbora Spodniakova, Lei Ma, Zuzana Gazova. Extracts from Chinese herbs with anti-amyloid and neuroprotective activities. International journal of biological macromolecules. 2021 May; 179(?):475-484. doi: 10.1016/j.ijbiomac.2021.03.013. [PMID: 33675837]
  • Zhuang-Zhuang Tang, Yu-Meng Zhang, Ting Zheng, Ting-Ting Huang, Teng-Fei Ma, Yao-Wu Liu. Sarsasapogenin alleviates diabetic nephropathy through suppression of chronic inflammation by down-regulating PAR-1: In vivo and in vitro study. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2020 Nov; 78(?):153314. doi: 10.1016/j.phymed.2020.153314. [PMID: 32882582]
  • Yue Liu, Zhuang-Zhuang Tang, Yu-Meng Zhang, Li Kong, Wei-Fen Xiao, Teng-Fei Ma, Yao-Wu Liu. Thrombin/PAR-1 activation induces endothelial damages via NLRP1 inflammasome in gestational diabetes. Biochemical pharmacology. 2020 05; 175(?):113849. doi: 10.1016/j.bcp.2020.113849. [PMID: 32059841]
  • Deepa K Ingawale, Satish K Mandlik, Snehal S Patel. Combination of Sarsasapogenin and Fluticasone attenuates ovalbumin-induced airway inflammation in a mouse asthma model. Immunopharmacology and immunotoxicology. 2020 Apr; 42(2):128-137. doi: 10.1080/08923973.2020.1728541. [PMID: 32070162]
  • Lixia Pei, Yiyi Ye, Wenshu Zhao, Qun Ye, Songlan Ge, Zi-Wei Jiang, Xiao-Qiang Liang, Hai-Xian Gan, Lei Ma. A validated UPLC-MS/MS method for quantitative determination of a potent neuroprotective agent Sarsasapogenin-AA13 in rat plasma: Application to pharmacokinetic studies. Biomedical chromatography : BMC. 2020 Mar; 34(3):e4775. doi: 10.1002/bmc.4775. [PMID: 31845362]
  • Priya Kashyap, Kalaivani Muthusamy, Manisha Niranjan, Shweta Trikha, Suresh Kumar. Sarsasapogenin: A steroidal saponin from Asparagus racemosus as multi target directed ligand in Alzheimer's disease. Steroids. 2020 01; 153(?):108529. doi: 10.1016/j.steroids.2019.108529. [PMID: 31672628]
  • Shu Wang, Mengqi Liu, Wenbao Wang, Ting Li, Mengsuo Cui, Wenliang Sun, Xinggang Yang, Shaojiang Song. Preparation and Evaluation of mPEG-PLGA Block Copolymer Micelles Loaded with a Sarsasapogenin Derivative. AAPS PharmSciTech. 2019 Aug; 20(7):280. doi: 10.1208/s12249-019-1491-z. [PMID: 31399832]
  • Lixia Pei, Songlan Ge, Yiyi Ye, Ziwei Jiang, Xiaoqiang Liang, Wenshu Zhao, Lei Ma. Development and validation of a UPLC-MS/MS method for determination of Sarsasapogenin-AA22 in rat plasma and its application to a pharmacokinetic study. Biomedical chromatography : BMC. 2018 Oct; 32(10):e4295. doi: 10.1002/bmc.4295. [PMID: 29797524]
  • Yao-Wu Liu, Yun-Chao Hao, Ya-Jing Chen, Shen-Yuan Yin, Meng-Ya Zhang, Li Kong, Tao-Yun Wang. Protective effects of sarsasapogenin against early stage of diabetic nephropathy in rats. Phytotherapy research : PTR. 2018 Aug; 32(8):1574-1582. doi: 10.1002/ptr.6088. [PMID: 29682805]
  • Yi Zhang, Lijun Jin, Jinchang Liu, Wei Wang, Haiyang Yu, Jian Li, Qian Chen, Tao Wang. Effect and mechanism of dioscin from Dioscorea spongiosa on uric acid excretion in animal model of hyperuricemia. Journal of ethnopharmacology. 2018 Mar; 214(?):29-36. doi: 10.1016/j.jep.2017.12.004. [PMID: 29233733]
  • Bo Yang, Zhirui Liu, Jing Hu, Xiaodan Lai, Peiyuan Xia. Quantitative determination of sarsasapogenin in rat plasma using liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2016 Jun; 1022(?):213-219. doi: 10.1016/j.jchromb.2016.04.020. [PMID: 27107248]
  • Rajarshi Sengupta, Amy Barone, Jayne Marasa, Sara Taylor, Erin Jackson, Nicole M Warrington, Shyam Rao, Albert H Kim, Jeffrey R Leonard, David Piwnica-Worms, Joshua B Rubin. Novel chemical library screen identifies naturally occurring plant products that specifically disrupt glioblastoma-endothelial cell interactions. Oncotarget. 2015 Jul; 6(21):18282-92. doi: 10.18632/oncotarget.4957. [PMID: 26286961]
  • Guo-long Li, Jie Yang, Jin-ao Duan, Hong-bo Liu, Zhen-hua Zhu, Da-wei Qian, Zhi-shu Tang. [Quality Analysis and Evaluation of Anemarrhena asphodeloides Rhizome from Different Habitats]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2015 Jun; 38(6):1148-52. doi: . [PMID: 26762052]
  • R Zhang, Z Wang, P A Howson, Z Xia, S Zhou, E Wu, Z Xia, Y Hu. Smilagenin attenuates beta amyloid (25-35)-induced degeneration of neuronal cells via stimulating the gene expression of brain-derived neurotrophic factor. Neuroscience. 2012 May; 210(?):275-85. doi: 10.1016/j.neuroscience.2012.03.017. [PMID: 22441042]
  • Christo Paul Preethy, Ramamoorthy Padmapriya, Vaiyapuri Subbarayan Periasamy, Anvarbatcha Riyasdeen, Suresh Srinag, Hanumanthappa Krishnamurthy, Ali Abdullah Alshatwi, Mohammad Abdulkader Akbarsha. Antiproliferative property of n-hexane and chloroform extracts of Anisomeles malabarica (L). R. Br. in HPV16-positive human cervical cancer cells. Journal of pharmacology & pharmacotherapeutics. 2012 Jan; 3(1):26-34. doi: 10.4103/0976-500x.92500. [PMID: 22368413]
  • Shi-Fu Xiao, Hai-Bo Xue, Xia Li, Chao Chen, Guan-Jun Li, Cheng-Mei Yuan, Ming-Yuan Zhang. A double-blind, placebo-controlled study of traditional Chinese medicine sarsasapogenin added to risperidone in patients with negative symptoms dominated schizophrenia. Neuroscience bulletin. 2011 Aug; 27(4):258-68. doi: 10.1007/s12264-011-1417-6. [PMID: 21788997]
  • Jagmohan S Negi, Pramod Singh, Geeta Joshi Nee Pant, M S M Rawat. High-performance liquid chromatography analysis of plant saponins: An update 2005-2010. Pharmacognosy reviews. 2011 Jul; 5(10):155-8. doi: 10.4103/0973-7847.91109. [PMID: 22303089]
  • M B Botura, G D Silva, H G Lima, J V A Oliveira, T S Souza, J D G Santos, A Branco, E L T Moreira, M A O Almeida, M J M Batatinha. In vivo anthelmintic activity of an aqueous extract from sisal waste (Agave sisalana Perr.) against gastrointestinal nematodes in goats. Veterinary parasitology. 2011 Apr; 177(1-2):104-10. doi: 10.1016/j.vetpar.2010.11.039. [PMID: 21156340]
  • Tabasum Sidiq, Anamika Khajuria, Pankaj Suden, Surjeet Singh, N K Satti, K A Suri, V K Srinivas, E Krishna, R K Johri. A novel sarsasapogenin glycoside from Asparagus racemosus elicits protective immune responses against HBsAg. Immunology letters. 2011 Mar; 135(1-2):129-35. doi: 10.1016/j.imlet.2010.10.013. [PMID: 21035507]
  • Liwei Wang, Xiaodong Wang, Xiaofan Yuan, Bing Zhao. Simultaneous analysis of diosgenin and sarsasapogenin in Asparagus officinalis byproduct by thin-layer chromatography. Phytochemical analysis : PCA. 2011 Jan; 22(1):14-7. doi: 10.1002/pca.1244. [PMID: 20799270]
  • Jing Wang, Ji-hua Liu, Xu Guo, Jian Zhang, Bo-yang Yu. A sensitive indirect competitive enzyme-linked immunosorbent assay for the detection of sarsasapogenin in rat plasma. Acta pharmacologica Sinica. 2010 Aug; 31(8):984-9. doi: 10.1038/aps.2010.85. [PMID: 20686523]
  • Nai-Dong Chen, Lei Yue, Jian Zhang, Jun-Ping Kou, Bo-Yang Yu. One unique steroidal sapogenin obtained through the microbial transformation of ruscogenin by Phytophthora cactorum ATCC 32134 and its potential inhibitory effect on tissue factor (TF) procoagulant activity. Bioorganic & medicinal chemistry letters. 2010 Jul; 20(14):4015-7. doi: 10.1016/j.bmcl.2010.05.103. [PMID: 20561785]
  • J S Negi, P Singh, G P Joshi, M S Rawat, V K Bisht. Chemical constituents of Asparagus. Pharmacognosy reviews. 2010 Jul; 4(8):215-20. doi: 10.4103/0973-7847.70921. [PMID: 22228964]
  • Ydia M Valadares, Geraldo C Brandão'a, Erna G Kroon, José D Souza Filho, Alaņņde B Oliveira, Fernão C Braga. Antiviral activity of Solanum paniculatum extract and constituents. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2009 Nov; 64(11-12):813-8. doi: 10.1515/znc-2009-11-1210. [PMID: 20158151]
  • Frank W King, Sylvia Fong, Chandi Griffin, Mark Shoemaker, Rick Staub, Yan-Ling Zhang, Isaac Cohen, Emma Shtivelman. Timosaponin AIII is preferentially cytotoxic to tumor cells through inhibition of mTOR and induction of ER stress. PloS one. 2009 Sep; 4(9):e7283. doi: 10.1371/journal.pone.0007283. [PMID: 19789631]
  • Bomi Lee, Kangsik Jung, Dong-Hyun Kim. Timosaponin AIII, a saponin isolated from Anemarrhena asphodeloides, ameliorates learning and memory deficits in mice. Pharmacology, biochemistry, and behavior. 2009 Aug; 93(2):121-7. doi: 10.1016/j.pbb.2009.04.021. [PMID: 19426756]
  • I Hakki Cigerci, A Fatih Fidan, Muhsin Konuk, Hayati Yuksel, Ismail Kucukkurt, Abdullah Eryavuz, Nalan Baysu Sozbilir. The protective potential of Yucca schidigera (Sarsaponin 30) against nitrite-induced oxidative stress in rats. Journal of natural medicines. 2009 Jul; 63(3):311-7. doi: 10.1007/s11418-009-0338-4. [PMID: 19434470]
  • Li Yang, Feng Feng, Yuan Gao. [Chemical constituents from herb of Solanum lyratum]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2009 Jul; 34(14):1805-8. doi: . [PMID: 19894512]
  • Nishant P Visavadiya, A V R L Narasimhacharya. Asparagus root regulates cholesterol metabolism and improves antioxidant status in hypercholesteremic rats. Evidence-based complementary and alternative medicine : eCAM. 2009 Jun; 6(2):219-26. doi: 10.1093/ecam/nem091. [PMID: 18955232]
  • Lina Xu, Yuetao Liu, Tie Wang, Yan Qi, Xu Han, Youwei Xu, Jinyong Peng, Xinqiang Tang. Development and validation of a sensitive and rapid non-aqueous LC-ESI-MS/MS method for measurement of diosgenin in the plasma of normal and hyperlipidemic rats: a comparative study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2009 May; 877(14-15):1530-6. doi: 10.1016/j.jchromb.2009.03.039. [PMID: 19372064]
  • Sang Hee Shim, Eun Ju Lee, Ju Sun Kim, Sam Sik Kang, Hyekyung Ha, Ho Young Lee, Chungsook Kim, Je-Hyun Lee, Kun Ho Son. Rat growth-hormone release stimulators from fenugreek seeds. Chemistry & biodiversity. 2008 Sep; 5(9):1753-61. doi: 10.1002/cbdv.200890164. [PMID: 18816528]
  • Xue-Feng Huang, Yu-Ying Lin, Ling-Yi Kong. Steroids from the roots of Asparagus officinalis and their cytotoxic activity. Journal of integrative plant biology. 2008 Jun; 50(6):717-22. doi: 10.1111/j.1744-7909.2008.00651.x. [PMID: 18713412]
  • Fei Sa, Jian-Li Gao, Kwok-Pui Fung, Ying Zheng, Simon Ming-Yuen Lee, Yi-Tao Wang. Anti-proliferative and pro-apoptotic effect of Smilax glabra Roxb. extract on hepatoma cell lines. Chemico-biological interactions. 2008 Jan; 171(1):1-14. doi: 10.1016/j.cbi.2007.08.012. [PMID: 17996228]
  • Bertrand Liagre, Pascale Vergne-Salle, David Y Leger, Jean-Louis Beneytout. Inhibition of human rheumatoid arthritis synovial cell survival by hecogenin and tigogenin is associated with increased apoptosis, p38 mitogen-activated protein kinase activity and upregulation of cyclooxygenase-2. International journal of molecular medicine. 2007 Oct; 20(4):451-60. doi: . [PMID: 17786275]
  • Juan Chen, Chong-jun Yang, Yu-hai Guo. [Studies on accumulation of active ingredients, N, P and K in Anemarrhena asphodeloides]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2007 Aug; 32(15):1504-7. doi: ". [PMID: 17972573]
  • Silvio Uhlig, Helene Wisløff, Dirk Petersen. Identification of cytotoxic constituents of Narthecium ossifragum using bioassay-guided fractionation. Journal of agricultural and food chemistry. 2007 Jul; 55(15):6018-26. doi: 10.1021/jf070776k. [PMID: 17602497]
  • Hua Zhou, Xi Yang, Naili Wang, Yaou Zhang, Guoping Cai. Tigogenin inhibits adipocytic differentiation and induces osteoblastic differentiation in mouse bone marrow stromal cells. Molecular and cellular endocrinology. 2007 May; 270(1-2):17-22. doi: 10.1016/j.mce.2007.01.017. [PMID: 17363141]
  • Shen Song, Tu-lin Lu, De Ji. [Investigation on the technology of processing Anemarrhena asphodeloides Bge. without hair by water]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2007 Mar; 30(3):335-8. doi: . [PMID: 17634045]
  • Han Yan, Lin Li, Xi Can Tang. Treating senile dementia with traditional Chinese medicine. Clinical interventions in aging. 2007; 2(2):201-8. doi: ". [PMID: 18044136]
  • Li-Xiang Ren, Yi-Fan Luo, Xia Li, Dai-Ying Zuo, Ying-Liang Wu. Antidepressant-like effects of sarsasapogenin from Anemarrhena asphodeloides BUNGE (Liliaceae). Biological & pharmaceutical bulletin. 2006 Nov; 29(11):2304-6. doi: 10.1248/bpb.29.2304. [PMID: 17077534]
  • Nan Liu, Xingbing Wen, Jihua Liu, Ming Liang, Huajin Zeng, Yining Lin, Boyang Yu. Determination of ruscogenin in crude Chinese medicines and biological samples by immunoassay. Analytical and bioanalytical chemistry. 2006 Nov; 386(6):1727-33. doi: 10.1007/s00216-006-0767-9. [PMID: 16957914]
  • Xuefeng Huang, Lingyi Kong. Steroidal saponins from roots of Asparagus officinalis. Steroids. 2006 Feb; 71(2):171-6. doi: 10.1016/j.steroids.2005.09.005. [PMID: 16280142]
  • Atsuko Kohara, Chiharu Nakajima, Kimiko Hashimoto, Toshihiko Ikenaga, Hiroyuki Tanaka, Yukihiro Shoyama, Shigeo Yoshida, Toshiya Muranaka. A novel glucosyltransferase involved in steroid saponin biosynthesis in Solanum aculeatissimum. Plant molecular biology. 2005 Jan; 57(2):225-39. doi: 10.1007/s11103-004-7204-2. [PMID: 15821879]
  • C Corbière, S Battu, B Liagre, P J P Cardot, J L Beneytout. SdFFF monitoring of cellular apoptosis induction by diosgenin and different inducers in the human 1547 osteosarcoma cell line. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2004 Sep; 808(2):255-62. doi: 10.1016/j.jchromb.2004.05.026. [PMID: 15261819]
  • Yoko Uematsu, Keiko Hirata, Kumi Suzuki, Kenji Iida, Kunihiro Kamata. Investigation of spectrophotometrically determined substances in Yucca extract by GC/MS, TLC and on-column injection GC. Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan. 2004 Jun; 45(3):141-5. doi: 10.3358/shokueishi.45.141. [PMID: 15468933]
  • Bertrand Liagre, Pascale Vergne-Salle, Cecile Corbiere, Jean L Charissoux, Jean L Beneytout. Diosgenin, a plant steroid, induces apoptosis in human rheumatoid arthritis synoviocytes with cyclooxygenase-2 overexpression. Arthritis research & therapy. 2004; 6(4):R373-83. doi: 10.1186/ar1199. [PMID: 15225373]
  • Jared I Loader, Alistair L Wilkins, Arne Flåøyen, Evrind Ryste, Knut Hove. Ovine metabolism of lithogenic sapogenins. Synthesis of [2,2,4,4-(2)h(4)]sarsasapogenone, [2,2,4,4-(2)h(4)]sarsasapogenin, and [2,2,4,4-(2)h(4)]episarsasapogenin and evaluation of deuterium retention in a sheep-dosing trial. Journal of agricultural and food chemistry. 2003 Apr; 51(9):2641-5. doi: 10.1021/jf026075z. [PMID: 12696951]
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