5-Keto-D-gluconate (BioDeep_00000003264)

 

Secondary id: BioDeep_00001869571

human metabolite Endogenous


代谢物信息卡片


2,3,4,6-tetrahydroxy-5-oxohexanoic acid

化学式: C6H10O7 (194.0427)
中文名称: 5-酮-D-葡糖酸
谱图信息: 最多检出来源 Homo sapiens(plant) 16.76%

分子结构信息

SMILES: C(C(=O)C(C(C(C(=O)O)O)O)O)O
InChI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h3-5,7,9-11H,1H2,(H,12,13)

描述信息

5-Keto-D-gluconate is metabolized from glucose in certain bacterial species. It is an intermediate in L-idonate degradation and ketogluconate metabolism. 5-Keto-D-gluconate 5-reductase catalyzes the reversible reduction of 5-ketogluconate to D-gluconate. This is the second reaction of the L-idonate catabolic pathway after uptake of L-idonate into the cell. The enzyme specifically reduces 5-ketogluconate using either NADH or NADPH. The enzyme is also specific for D-gluconate oxidation using NADP as the coenzyme, NAD does not serve as a coenzyme. 5-Keto-D-gluconate has also been found to be a metabolite of Gluconobacter (https://www.sciencedirect.com/science/article/pii/S138111779800112X).
5-Keto-D-gluconate is metabolized from glucose in certain bacterial species. It is an intermediate in L-idonate degradation and ketogluconate metabolism. 5-Keto-D-gluconate 5-reductase catalyzes the reversible reduction of 5-ketogluconate to D-gluconate. This is the second reaction of the L-idonate catabolic pathway after uptake of L-idonate into the cell. The enzyme specifically reduces 5-ketogluconate using either NADH or NADPH. The enzyme is also specific for D-gluconate oxidation using NADP as the coenzyme, NAD does not serve as a coenzyme. [HMDB]

同义名列表

16 个代谢物同义名

2,3,4,6-tetrahydroxy-5-oxohexanoic acid; D-xylo-5-hexulosonic acid; D-Lyxo-5-hexulosonic acid; 5-Dehydrogluconic acid; 5-Keto-D-gluconic acid; 5-dehydro-D-Gluconate; hex-5-ulosonic acid; D-tagaturonic acid; 5-Dehydrogluconate; 5-Keto-D-gluconate; 5-Ketogluconate; D-Tagaturonate; 5-K-Gluconate; Tagaturonate; 5K-Gluconate; 5-Keto-D-gluconic acid



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

3 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(1)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(2)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 4 CAT, GGPS1, PURA, SYK
Peripheral membrane protein 2 HSD17B6, SORD
Endoplasmic reticulum membrane 1 TKT
Mitochondrion membrane 1 SORD
Nucleus 3 FEN1, PURA, SYK
cytosol 7 CAT, GGPS1, PHYH, SORD, STX1A, SYK, TKT
dendrite 1 PURA
mitochondrial membrane 1 SORD
nuclear body 1 TKT
nucleoplasm 3 FEN1, GGPS1, TKT
Cell membrane 3 STX1A, SYK, TKT
Early endosome membrane 1 HSD17B6
Golgi apparatus membrane 1 MGAT1
glutamatergic synapse 1 PURA
Golgi apparatus 1 MGAT1
Golgi membrane 1 MGAT1
neuronal cell body 1 PURA
postsynapse 1 PURA
synaptic vesicle 1 STX1A
Cytoplasm, cytosol 1 SYK
plasma membrane 3 STX1A, SYK, TKT
synaptic vesicle membrane 1 STX1A
Membrane 4 CAT, FEN1, MGAT1, SORD
apical plasma membrane 1 TKT
axon 1 STX1A
extracellular exosome 4 CAT, MGAT1, SORD, TKT
Lumenal side 1 HSD17B6
endoplasmic reticulum 1 HSD17B6
extracellular space 1 SORD
perinuclear region of cytoplasm 2 GGPS1, MGAT1
mitochondrion 2 CAT, FEN1
protein-containing complex 3 CAT, FEN1, SYK
intracellular membrane-bounded organelle 2 CAT, HSD17B6
Microsome membrane 1 HSD17B6
Single-pass type I membrane protein 1 TKT
extracellular region 2 CAT, STX1A
[Isoform 2]: Secreted 1 STX1A
mitochondrial matrix 1 CAT
motile cilium 1 SORD
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 STX1A
nuclear membrane 1 STX1A
Extracellular vesicle 1 MGAT1
actin cytoskeleton 1 TKT
Z disc 1 GGPS1
nucleolus 1 FEN1
Single-pass type II membrane protein 1 MGAT1
vesicle 1 TKT
presynaptic active zone membrane 1 STX1A
Cytoplasm, perinuclear region 2 GGPS1, MGAT1
focal adhesion 2 CAT, TKT
Peroxisome 3 CAT, PHYH, TKT
Peroxisome matrix 1 CAT
peroxisomal matrix 2 CAT, PHYH
peroxisomal membrane 1 CAT
receptor complex 1 TKT
neuron projection 1 STX1A
Nucleus, nucleolus 1 FEN1
chromosome, telomeric region 2 FEN1, PURA
Cell projection, cilium, flagellum 1 SORD
Endomembrane system 1 STX1A
Nucleus, nucleoplasm 1 FEN1
Cytoplasm, myofibril, sarcomere, Z line 1 GGPS1
SNARE complex 1 STX1A
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 1 CAT
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 MGAT1
Single-pass type IV membrane protein 1 STX1A
9+0 non-motile cilium 1 PHYH
Synapse, synaptosome 1 STX1A
early phagosome 1 SYK
T cell receptor complex 1 SYK
catalase complex 1 CAT
B cell receptor complex 1 SYK
[Isoform FENMIT]: Mitochondrion 1 FEN1
synaptobrevin 2-SNAP-25-syntaxin-1a complex 1 STX1A


文献列表

  • V S Saravanan, P Kalaiarasan, M Madhaiyan, M Thangaraju. Solubilization of insoluble zinc compounds by Gluconacetobacter diazotrophicus and the detrimental action of zinc ion (Zn2+) and zinc chelates on root knot nematode Meloidogyne incognita. Letters in applied microbiology. 2007 Mar; 44(3):235-41. doi: 10.1111/j.1472-765x.2006.02079.x. [PMID: 17309498]
  • V S Saravanan, M Madhaiyan, M Thangaraju. Solubilization of zinc compounds by the diazotrophic, plant growth promoting bacterium Gluconacetobacter diazotrophicus. Chemosphere. 2007 Jan; 66(9):1794-8. doi: 10.1016/j.chemosphere.2006.07.067. [PMID: 16956644]
  • M K Samson, R L Stephens, S Rivkin, M Opipari, T Maloney, C W Groppe, R Fisher. Vinblastine, bleomycin, and cis-dichlorodiammineplatinum(II) in disseminated testicular cancer: preliminary report of a Southwest Oncology Group Study. Cancer treatment reports. 1979 Sep; 63(9-10):1663-7. doi: . [PMID: 91435]