trans-Piceid (BioDeep_00000003245)

Main id: BioDeep_00000230980

 

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite


代谢物信息卡片


(2S,3R,4S,5S,6R)-2-{3-hydroxy-5-[(E)-2-(4-hydroxyphenyl)ethenyl]phenoxy}-6-(hydroxymethyl)oxane-3,4,5-triol

化学式: C20H22O8 (390.1315)
中文名称: 虎杖苷, 白藜芦醇苷
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=C(O)C=C(/C=C/C2=CC=C(O)C=C2)C=C1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1
InChI: InChI=1S/C20H22O8/c21-10-16-17(24)18(25)19(26)20(28-16)27-15-8-12(7-14(23)9-15)2-1-11-3-5-13(22)6-4-11/h1-9,16-26H,10H2/b2-1+/t16-,17+,18+,19-,20-/m1/s1

描述信息

trans-Piceid is found in alcoholic beverages. trans-Piceid is present in grapeskins and red wine. It is isolated from Polygonum cuspidatum (Japanese knotweed).Piceid is a stilbenoid glucoside and is a major resveratrol derivative in grape juices
(E/Z)-Polydatin ((E/Z)-Piceid) is a monocrystalline compound originally isolated from the root and rhizome of Polygonum cuspidatum. (E/Z)-Polydatin has anti-platelet aggregation, anti-oxidative action of low-density lipoprotein (LDL), cardioprotective activity, anti-inflammatory and immune-regulating functions[1].
(E/Z)-Polydatin ((E/Z)-Piceid) is a monocrystalline compound originally isolated from the root and rhizome of Polygonum cuspidatum. (E/Z)-Polydatin has anti-platelet aggregation, anti-oxidative action of low-density lipoprotein (LDL), cardioprotective activity, anti-inflammatory and immune-regulating functions[1].
(E/Z)-Polydatin ((E/Z)-Piceid) is a monocrystalline compound originally isolated from the root and rhizome of Polygonum cuspidatum. (E/Z)-Polydatin has anti-platelet aggregation, anti-oxidative action of low-density lipoprotein (LDL), cardioprotective activity, anti-inflammatory and immune-regulating functions[1].
Polydatin (Piceid), extracted from the roots of Reynoutria japonica, a widely used traditional Chinese remedies, possesses anti-inflammatory activity in several experimental models. Polydatin (Piceid) inhibits G6PD and induces oxidative and ER stresses.
Polydatin (Piceid), extracted from the roots of Reynoutria japonica, a widely used traditional Chinese remedies, possesses anti-inflammatory activity in several experimental models. Polydatin (Piceid) inhibits G6PD and induces oxidative and ER stresses.
Polydatin (Standard) is the analytical standard of Polydatin. This product is intended for research and analytical applications. Polydatin (Piceid), extracted from the roots of Reynoutria japonica, a widely used traditional Chinese remedies, possesses anti-inflammatory activity in several experimental models. Polydatin (Piceid) inhibits G6PD and induces oxidative and ER stresses.

同义名列表

80 个代谢物同义名

(2S,3R,4S,5S,6R)-2-{3-hydroxy-5-[(E)-2-(4-hydroxyphenyl)ethenyl]phenoxy}-6-(hydroxymethyl)oxane-3,4,5-triol; 3-Hydroxy-5-[(1E)-2-(4-hydroxyphenyl)ethenyl]phenyl beta-D-glucopyranoside; 3-Hydroxy-5-[(1E)-2-(4-hydroxyphenyl)ethenyl]phenyl β-D-glucopyranoside; 3-hydroxy-5-(2-(4-hydroxyphenyl)ethenyl)phenyl-beta-D-glucoside; 3,3,4,5-Tetrahydroxystilbene 3-O-beta-D-glucopyranoside; trans-3,5,4-Trihydroxystilbene 3-O-beta-glucopyranoside; trans-3,5,4’-Trihydroxystilbene 3-O-β-glucopyranoside; trans-3,5,4-Trihydroxystilbene 3-O-β-glucopyranoside; 3-Hydroxy-5-(p-hydroxystyryl)phenyl beta-D-glucoside; trans-3,5,4-Trihydroxystilbene 3-O-beta-glucoside; 3,4-5-Trihydroxystilbene-3-beta-D-glucopyranoside; (-)-trans-Resveratrol 13-O-beta-D-glucopyranoside; 3-Hydroxy-5-(p-hydroxystyryl)phenyl β-D-glucoside; 3,5,4-Trihydroxystilbene 3-O-beta-glucopyranoside; 3,5,4’-Trihydroxystilbene 3-O-β-glucopyranoside; trans-3,5,4’-Trihydroxystilbene 3-O-β-glucoside; 3,5,4-Trihydroxystilbene 3-O-β-glucopyranoside; (-)-trans-Resveratrol 13-O-β-D-glucopyranoside; trans-3,5,4-Trihydroxystilbene 3-O-β-glucoside; trans-3,5,4’-Trihydroxystilbene 3-O-glucoside; 3,4,5-trihydroxystilbene-3-beta-monoglucoside; trans-3,5,4-Trihydroxystilbene 3-O-glucoside; trans-3,5,4’-Trihydroxystilbene 3-glucoside; 3,4,5-trihydroxystilbene-3-beta-D-glucoside; 3,5,4-Trihydroxystilbene 3-O-beta-glucoside; 3,4,5-Trihydroxystilbene-3-β-monoglucoside; trans-3,5,4-Trihydroxystilbene 3-glucoside; (E)-Resveratrol 3-O-beta-D-glucopyranoside; 3,4,5-Trihydroxystilbene-3-b-monoglucoside; 3,5,4’-Trihydroxystilbene 3-O-β-glucoside; 3,5,4-Trihydroxystilbene 3-O-β-glucoside; 3,4,5-Trihydroxystilbene-3-b-D-glucoside; 3,4,5-Trihydroxystilbene-3-β-D-glucoside; (E)-Resveratrol 3-O-β-D-glucopyranoside; 3,5,4’-Trihydroxystilbene 3-O-glucoside; 3,5,4-Trihydroxystilbene 3-O-glucoside; trans-resveratrol 3-O-beta-D-glucoside; 5,4-dihydroxystilbene-3-O-beta-D-Glcp; 3,5,4’-Trihydroxystilbene 3-glucoside; Resveratrol 3-O-beta-glucopyranoside; 3,5,4-Trihydroxystilbene 3-glucoside; trans-resveratrol 3-beta-D-glucoside; trans-Resveratrol 3-O-β-D-glucoside; Resveratrol 3-beta-mono-D-glucoside; trans-Resveratrol 3-O-b-D-glucoside; trans-resveratrol 3-beta-glucoside; trans-Resveratrol 3-β-D-glucoside; Resveratrol 3-O-β-glucopyranoside; trans-Resveratrol 3-b-D-glucoside; resveratrol 3-O-beta-D-glucoside; trans-Resveratrol 3-b-glucoside; trans-Resveratrol 3-β-glucoside; trans-Resveratrol 3-O-glucoside; Resveratrol 3-beta-D-glucoside; Resveratrol 3-O-β-D-glucoside; trans-Resveratrol 3-glucoside; Resveratrol beta-D-glucoside; Resveratrol beta-glucoside; Resveratrol β-D-glucoside; Resveratrol 3-O-glucoside; Resveratrol 5-O-glucoside; 3-O-Glucosyl-resveratrol; Resveratrol 3-Glucoside; Resveratrol β-glucoside; polydatin, (E)-isomer; Resveratrol glucoside; Polydotin peceid; trans-Polydatin; (E/Z)-Polydatin; (E)-Polydatin; (E/Z)-Piceid; Trans-Piceid; (E)-Piceid; 3,4,5-Tsg; Polydatin; Pieceid; piceid; Piceid (Standard); Polydatin (Standard); Piceid



数据库引用编号

22 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

89 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 CASP3, CASP7, CAT, MAPK7, MITF, TTN, TYR, TYRP1
Peripheral membrane protein 1 GBA1
Endosome membrane 1 TYRP1
Endoplasmic reticulum membrane 2 MLANA, UGT1A1
Nucleus 8 CASP3, CASP7, ESR2, GABPA, MAPK7, MITF, MYB, TTN
cytosol 8 CASP3, CASP7, CAT, MAPK7, MITF, MYB, SCLY, TTN
trans-Golgi network 2 GBA1, MLANA
nucleoplasm 7 CASP3, CASP7, ESR2, GABPA, MAPK7, MITF, MYB
RNA polymerase II transcription regulator complex 1 MYB
Cell membrane 1 TNF
Multi-pass membrane protein 1 SLC5A1
cell surface 2 F3, TNF
glutamatergic synapse 1 CASP3
Golgi apparatus 3 GBA1, MLANA, SCLY
lysosomal membrane 3 GAA, GBA1, MITF
neuronal cell body 2 CASP3, TNF
Cytoplasm, cytosol 2 CASP7, SCLY
Lysosome 3 GAA, GBA1, TYR
plasma membrane 7 F3, GAA, LCT, MLANA, SLC5A1, TNF, UGT1A1
Membrane 5 CAT, F3, GAA, MYB, UGT1A1
apical plasma membrane 1 SLC5A1
extracellular exosome 5 CAT, GAA, GBA1, SLC5A1, TTN
Lysosome membrane 3 GAA, GBA1, MITF
Lumenal side 1 GBA1
endoplasmic reticulum 2 GBA1, UGT1A1
extracellular space 3 CASP7, F3, TNF
lysosomal lumen 2 GAA, GBA1
perinuclear region of cytoplasm 3 SLC5A1, TYR, UGT1A1
mitochondrion 2 CAT, ESR2
protein-containing complex 2 CAT, MITF
intracellular membrane-bounded organelle 4 CAT, ESR2, GAA, TYR
postsynaptic density 1 CASP3
Single-pass type I membrane protein 4 F3, LCT, TYR, TYRP1
Secreted 1 GAA
extracellular region 4 CAT, GAA, TNF, TTN
Single-pass membrane protein 1 UGT1A1
[Isoform 1]: Membrane 1 F3
[Isoform 2]: Secreted 1 F3
mitochondrial matrix 1 CAT
external side of plasma membrane 2 F3, TNF
Z disc 1 TTN
Melanosome membrane 3 MLANA, TYR, TYRP1
Early endosome 1 SLC5A1
Golgi-associated vesicle 1 TYR
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Apical cell membrane 2 LCT, SLC5A1
Cytoplasm, perinuclear region 1 UGT1A1
Membrane raft 1 TNF
focal adhesion 1 CAT
Peroxisome 1 CAT
intracellular vesicle 2 SLC5A1, TYRP1
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
PML body 1 MAPK7
collagen-containing extracellular matrix 1 F3
chromatin 3 ESR2, GABPA, MITF
phagocytic cup 1 TNF
Secreted, extracellular space 1 CASP7
brush border membrane 1 SLC5A1
I band 1 TTN
M band 1 TTN
tertiary granule membrane 1 GAA
Melanosome 3 MLANA, TYR, TYRP1
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 1 CAT
nuclear matrix 1 MYB
azurophil granule membrane 1 GAA
condensed nuclear chromosome 1 TTN
clathrin-coated endocytic vesicle membrane 1 TYRP1
ficolin-1-rich granule membrane 1 GAA
external side of apical plasma membrane 1 LCT
death-inducing signaling complex 1 CASP3
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
catalase complex 1 CAT
catalytic complex 1 SCLY
endoplasmic reticulum chaperone complex 1 UGT1A1
serine-type peptidase complex 1 F3
autolysosome lumen 1 GAA
intracellular organelle 1 SLC5A1
cytochrome complex 1 UGT1A1
striated muscle thin filament 1 TTN
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
organelle 1 TTN


文献列表

  • Ke Liu, Jiaxi Liu, Anjian Xu, Junying Ding. The role of polydatin in inhibiting oxidative stress through SIRT1 activation: A comprehensive review of molecular targets. Journal of ethnopharmacology. 2024 Sep; 331(?):118322. doi: 10.1016/j.jep.2024.118322. [PMID: 38729537]
  • Thanh Dat Mai, Hyun Min Kim, Seo Young Park, Sang Hoon Ma, Ju Hui Do, Won Choi, Hye Min Jang, Hyeon Bae Hwang, Eun Gyeong Song, Jae Sung Shim, Young Hee Joung. Metabolism of phenolic compounds catalyzed by Tomato CYP736A61. Enzyme and microbial technology. 2024 May; 176(?):110425. doi: 10.1016/j.enzmictec.2024.110425. [PMID: 38479200]
  • Tao Liu, Rui Han, Yiqi Yan. Preliminary study on molecular mechanism of COVID-19 intervention by Polygonum cuspidatum through computer bioinformatics. Medicine. 2024 Jan; 103(2):e36918. doi: 10.1097/md.0000000000036918. [PMID: 38215091]
  • Soykan Agar, Barbaros Akkurt, Engin Ulukaya. The Inhibition Mechanism of Pancreatic Ductal Adenocarcinoma via LXR Receptors: A Multifaceted Approach Integrating Molecular Docking, Molecular Dynamics and Post-MD Inter-Molecular Contact Analysis. Asian Pacific journal of cancer prevention : APJCP. 2023 Dec; 24(12):4103-4109. doi: 10.31557/apjcp.2023.24.12.4103. [PMID: 38156844]
  • Jie Tang, Lixiang Wang, Mengge Shi, Shuaixia Feng, Tong Zhang, Han Han. Study on the mechanism of Shuganzhi Tablet against nonalcoholic fatty liver disease and lipid regulation effects of its main substances in vitro. Journal of ethnopharmacology. 2023 Nov; 316(?):116780. doi: 10.1016/j.jep.2023.116780. [PMID: 37311504]
  • Jiannan Liu, Jianlin Huang, Bo Gong, Songtao Cheng, Yadong Liu, Yaodong Chen, Qiang Feng, Jun Li, Mingxing Qiu, Gui Yu, Yong Liao. Polydatin protects against calcium oxalate crystal-induced renal injury through the cytoplasmic/mitochondrial reactive oxygen species-NLRP3 inflammasome pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Nov; 167(?):115621. doi: 10.1016/j.biopha.2023.115621. [PMID: 37793278]
  • Yongli Liu, Fang Xie, Changhuai Lu, Zongbo Zhou, Shudong Li, Jia Zhong, Qian Li, Xianfang Shao. Polydatin inhibited TNF-α-induced apoptosis of skeletal muscle cells through AKT-mediated p38 MAPK and NF-κB pathways. General physiology and biophysics. 2023 Nov; 42(6):521-529. doi: 10.4149/gpb_2023027. [PMID: 37994428]
  • Xiaodan Guan, Liang Jin, Huifen Zhou, Jing Chen, Haofang Wan, Yida Bao, Jiehong Yang, Daojun Yu, Haitong Wan. Polydatin prevent lung epithelial cell from Carbapenem-resistant Klebsiella pneumoniae injury by inhibiting biofilm formation and oxidative stress. Scientific reports. 2023 10; 13(1):17736. doi: 10.1038/s41598-023-44836-7. [PMID: 37853059]
  • Ruimin Wang, Ruyan Fan, Tingyu Meng, Lu Wang. Exploration of the inhibitory mechanisms of trans-polydatin/resveratrol on α-glucosidase by multi-spectroscopic analysis, in silico docking and molecular dynamics simulation. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2023 Oct; 299(?):122866. doi: 10.1016/j.saa.2023.122866. [PMID: 37201332]
  • Yiliu Chen, Yonghong Jiang, Xiuxiu Liu, Xiufeng Chen, Qiuyue Fan, Zhen Xiao. Polydatin alleviates mycoplasma pneumoniae-induced injury via inhibition of Caspase-1/GSDMD-dependent pyroptosis. International journal of medical microbiology : IJMM. 2023 Sep; 313(5):151586. doi: 10.1016/j.ijmm.2023.151586. [PMID: 37776814]
  • Jingxiao Yang, Yuanqing Wang, Xiong Cai, Binqing Qu, Ye Zhang, Zhicheng Sun, Jianye Yan. Comparative pharmacokinetics and tissue distribution of polydatin, resveratrol, and emodin after oral administration of Huzhang and Huzhang-Guizhi herb-pair extracts to rats. Journal of ethnopharmacology. 2023 Aug; ?(?):117010. doi: 10.1016/j.jep.2023.117010. [PMID: 37557937]
  • Zhengju Zhang, Xinqi Deng, Wen Gu, Yang Jiao, Canyu Su, Hui Liu, Weiguo Ma, Honghong Zhang, Ruiyang Xiang, Dali Wang, Yanan Wang, Wang Chunguo, Fengxian Meng. Jianghu decoction and its active component polydatin inhibit inflammation and fibrotic lesions in the lungs of ILD mice via the AMPK signaling pathway. Journal of ethnopharmacology. 2023 Aug; 318(Pt B):117003. doi: 10.1016/j.jep.2023.117003. [PMID: 37543150]
  • Zhengming Xu, Shuang Liu, Huining Lai, Lijun You, Zhengang Zhao. Green-Efficient Enzymatic Synthesis and Characterization of Liposoluble 6'/6″-O-Lauryl Phenolic Glycosides with Enhanced Intestinal Permeability. Journal of agricultural and food chemistry. 2023 May; 71(20):7689-7702. doi: 10.1021/acs.jafc.3c00527. [PMID: 37167604]
  • Liqing Wang, Menghan Chen, Qihui Sun, Yong Yang, Rong Rong. Discovery of the potential neuraminidase inhibitors from Polygonum cuspidatum by ultrafiltration combined with mass spectrometry guided by molecular docking. Journal of separation science. 2023 May; 46(10):e2200937. doi: 10.1002/jssc.202200937. [PMID: 36905353]
  • Xiaonan Zhang, Zeping Wang, Xiaoya Li, Jiye Che, Zongliang Yu, Xin Li, Changxin Sun, Lanqing Hu, Min Wu, Longtao Liu. Polydatin protects against atherosclerosis by activating autophagy and inhibiting pyroptosis mediated by the NLRP3 inflammasome. Journal of ethnopharmacology. 2023 Mar; ?(?):116304. doi: 10.1016/j.jep.2023.116304. [PMID: 36870461]
  • Y P Hai, A C H Lee, K Chen, G J Kahaly. Traditional Chinese medicine in thyroid-associated orbitopathy. Journal of endocrinological investigation. 2023 Feb; ?(?):. doi: 10.1007/s40618-023-02024-4. [PMID: 36781592]
  • Huajie Tian, Yi Fang, Wei Liu, Jun Wang, Jianan Zhao, Hao Tang, Yixiao Yin, Yiyang Hu, Jinghua Peng. Inhibition on XBP1s-driven lipogenesis by Qushi Huayu Decoction contributes to amelioration of hepatic steatosis induced by fructose. Journal of ethnopharmacology. 2023 Jan; 301(?):115806. doi: 10.1016/j.jep.2022.115806. [PMID: 36216198]
  • Qin Li, Peng Zhao, Yu Wen, Zhimin Zou, Xihe Qin, Hongping Tan, Jian Gong, Qihua Wu, Chen Zheng, Kun Zhang, Qiaobing Huang, Marc Maegele, Zhengtao Gu, Li Li. Polydatin ameliorates TBI induced secondary brain injury by inhibiting NLRP3-induced neuroinflammation associated with SOD2 acetylation. Shock (Augusta, Ga.). 2022 Dec; ?(?):. doi: 10.1097/shk.0000000000002066. [PMID: 36477654]
  • Wenqi Jin, Meiling Fan, Yuxin Zhang, Qi Zhang, Chenxu Jing, Rui Jiang, Chunli Piao, Liwei Sun. Polydatin prevents lipotoxicity-induced dysfunction in pancreatic β-cells by inhibiting endoplasmic reticulum stress and excessive autophagy. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Nov; 106(?):154410. doi: 10.1016/j.phymed.2022.154410. [PMID: 36030747]
  • Muhammad Ajmal Shah, Ayesha Hamid, Hafiza Ishmal Faheem, Azhar Rasul, Tourki A S Baokbah, Muhammad Haris, Rimsha Yousaf, Uzma Saleem, Shabnoor Iqbal, Maria Silvana Alves, Zahid Khan, Ghulam Hussain, Ifat Alsharfi, Haroon Khan, Philippe Jeandet. Uncovering the Anticancer Potential of Polydatin: A Mechanistic Insight. Molecules (Basel, Switzerland). 2022 Oct; 27(21):. doi: 10.3390/molecules27217175. [PMID: 36364001]
  • Dajie Wang, Zhaofeng Zhou, Liang Yuan. Polydatin reverses oxidation low lipoprotein (oxLDL)-induced apoptosis of human umbilical vein endothelial cells via regulating the miR-26a-5p/BID axis. European journal of histochemistry : EJH. 2022 Sep; 66(4):. doi: 10.4081/ejh.2022.3505. [PMID: 36128773]
  • Yao-Jun Liu, Wei-Heng Xu, Li-Ming Fan, Yu-Qin Zhang, Wen Xu, Ya-Ping Chen, Lin-Lin Chen, Li Chen, Wei Xu, Yan Wang, Ke-Dan Chu, Jun-Ping Zhang. Polydatin alleviates DSS- and TNBS-induced colitis by suppressing Th17 cell differentiation via directly inhibiting STAT3. Phytotherapy research : PTR. 2022 Sep; 36(9):3662-3671. doi: 10.1002/ptr.7533. [PMID: 35766233]
  • Rong-Hong Zhang, Dan Yang, Xiang-Ming Liao, Hong Zhang, Guo-Qi Chen, Wen-Li Zhang, Yu-Chan Wang, Cong Wang, Shang-Gao Liao, Meng Zhou, Yong-Lin Wang, Yong-Jun Li. Design, synthesis, and in vitro protective effect evaluation of α-carboline derivatives against H2O2-induced cardiomyocyte injury. European journal of medicinal chemistry. 2022 Aug; 238(?):114469. doi: 10.1016/j.ejmech.2022.114469. [PMID: 35605360]
  • Lin Huang, Jiawei Chen, Xiaojie Li, Mingxin Huang, Jilou Liu, Na Qin, Zhenhua Zeng, Xingmin Wang, Fen Li, Hong Yang. Polydatin Improves Sepsis-Associated Encephalopathy by Activating Sirt1 and Reducing p38 Phosphorylation. The Journal of surgical research. 2022 08; 276(?):379-393. doi: 10.1016/j.jss.2022.03.008. [PMID: 35447391]
  • Jinli Luo, Shuo Chen, Li Wang, Xiaohua Zhao, Chunli Piao. Pharmacological effects of polydatin in the treatment of metabolic diseases: A review. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Jul; 102(?):154161. doi: 10.1016/j.phymed.2022.154161. [PMID: 35636169]
  • Y Yuan, G Feng, J Yang, C Yang, Y-H Tu. Polydatin alleviates osteoporosis by enhancing the osteogenic differentiation of osteoblasts. European review for medical and pharmacological sciences. 2022 Jun; 26(12):4392-4402. doi: 10.26355/eurrev_202206_29078. [PMID: 35776040]
  • Xuemei Xue, Fei Deng, Zhenkai Ge, Jingwen Meng, Xiya Liu, Yongheng Zhao, Yanggen Hu, Xu Ling. Conductive polymer sorbent for extraction and determination of resveratrol and polydatin in Polygonum cuspidatum root samples. Phytochemical analysis : PCA. 2022 Jun; 33(4):590-598. doi: 10.1002/pca.3112. [PMID: 35098595]
  • Can Liu, Wenyi Wang, Kaixin Zhang, Qiudi Liu, Tongyao Ma, Li Tan, Lanqing Ma. Protective Effects of Polydatin from Grapes and Reynoutria japonica Houtt. on Damaged Macrophages Treated with Acetaminophen. Nutrients. 2022 May; 14(10):. doi: 10.3390/nu14102077. [PMID: 35631218]
  • Jie Zhou, Meng Liang, Yu Lin, Hao Pang, Yutuo Wei, Ribo Huang, Liqin Du. Application of β-Glucosidase in a Biphasic System for the Efficient Conversion of Polydatin to Resveratrol. Molecules (Basel, Switzerland). 2022 Feb; 27(5):. doi: 10.3390/molecules27051514. [PMID: 35268615]
  • N Qin, L Huang, R Dong, F Li, X Tang, Z Zeng, X Wang, H Yang. [Polydatin improves intestinal barrier injury after traumatic brain injury in rats by reducing oxidative stress and inflammatory response via activating SIRT1-mediated deacetylation of SOD2 and HMGB1]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. 2022 Jan; 42(1):93-100. doi: 10.12122/j.issn.1673-4254.2022.01.11. [PMID: 35249875]
  • Dandan Tang, Qing Zhang, Huxinyue Duan, Xun Ye, Jia Liu, Wei Peng, Chunjie Wu. Polydatin: A Critical Promising Natural Agent for Liver Protection via Antioxidative Stress. Oxidative medicine and cellular longevity. 2022; 2022(?):9218738. doi: 10.1155/2022/9218738. [PMID: 35186191]
  • Penghui Ye, Hefei Wu, Yinxiao Jiang, Xiaolin Xiao, Dan Song, Nuo Xu, Xiao Ma, Jinhao Zeng, Yaoguang Guo. Old dog, new tricks: Polydatin as a multitarget agent for current diseases. Phytotherapy research : PTR. 2022 Jan; 36(1):214-230. doi: 10.1002/ptr.7306. [PMID: 34936712]
  • Huihui Zhang, Yadan Li, Yu Xun, Hui Liu, Chenxi Wei, Hao Wang, Xiaoping Yang, Shishan Yuan, Ning Liu, Shuanglin Xiang. Polydatin protects neuronal cells from hydrogen peroxide damage by activating CREB/Ngb signaling. Molecular medicine reports. 2022 01; 25(1):. doi: 10.3892/mmr.2021.12525. [PMID: 34751416]
  • Lu Zhou, Peng Yu, Ting-Ting Wang, Yi-Wei Du, Yang Chen, Zhen Li, Man-Lin He, Lan Feng, Hui-Rong Li, Xiao Han, Heng Ma, Hong-Bao Liu. Polydatin Attenuates Cisplatin-Induced Acute Kidney Injury by Inhibiting Ferroptosis. Oxidative medicine and cellular longevity. 2022; 2022(?):9947191. doi: 10.1155/2022/9947191. [PMID: 35075382]
  • Ziwei Li, Xiaoman Chen, Guo Liu, Jun Li, Jinglin Zhang, Yong Cao, Jianyin Miao. Antioxidant Activity and Mechanism of Resveratrol and Polydatin Isolated from Mulberry (Morus alba L.). Molecules (Basel, Switzerland). 2021 Dec; 26(24):. doi: 10.3390/molecules26247574. [PMID: 34946655]
  • Robin Sunsong, Ting Du, Imoh Etim, Yun Zhang, Dong Liang, Song Gao. Development of a novel UPLC-MS/MS method for the simultaneously quantification of polydatin and resveratrol in plasma: Application to a pharmacokinetic study in rats. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2021 Nov; 1185(?):123000. doi: 10.1016/j.jchromb.2021.123000. [PMID: 34710805]
  • Huan Xu, Jing Li, Shidong Song, Zhen Xiao, Xuanqing Chen, Boxuan Huang, Mengsi Sun, Guoqing Su, Demin Zhou, Guanyu Wang, Ran Hao, Na Wang. Effective inhibition of coronavirus replication by Polygonum cuspidatum. Frontiers in bioscience (Landmark edition). 2021 10; 26(10):789-798. doi: 10.52586/4988. [PMID: 34719206]
  • Sajad Fakhri, Mohammad Mehdi Gravandi, Sadaf Abdian, Esra Küpeli Akkol, Mohammad Hosein Farzaei, Eduardo Sobarzo-Sánchez. The Neuroprotective Role of Polydatin: Neuropharmacological Mechanisms, Molecular Targets, Therapeutic Potentials, and Clinical Perspective. Molecules (Basel, Switzerland). 2021 Oct; 26(19):. doi: 10.3390/molecules26195985. [PMID: 34641529]
  • Yijie Lou, Kaxi Yu, Xiajun Wu, Zhaojun Wang, Yusheng Cui, Hanxiao Bao, Jianwei Wang, Xiurong Hu, Yunxi Ji, Guping Tang. Co-Crystals of Resveratrol and Polydatin with L-Proline: Crystal Structures, Dissolution Properties, and In Vitro Cytotoxicities. Molecules (Basel, Switzerland). 2021 Sep; 26(18):. doi: 10.3390/molecules26185722. [PMID: 34577193]
  • Jie Cao, Baojian Guo, Sai Li, Xaojing Zhang, Xiaoqi Zhang, Gaoxiao Zhang, Yewei Sun, Yuqiang Wang, Xiubao Song, Zaijun Zhang. Neuroprotection against 1-Methyl-4-phenylpyridinium-induced cytotoxicity by naturally occurring polydatin through activation of transcription factor MEF2D. Neuroreport. 2021 08; 32(12):1065-1072. doi: 10.1097/wnr.0000000000001696. [PMID: 34232128]
  • Fulvio Perrella, Federico Coppola, Alessio Petrone, Chiara Platella, Daniela Montesarchio, Annarita Stringaro, Giampietro Ravagnan, Maria Pia Fuggetta, Nadia Rega, Domenica Musumeci. Interference of Polydatin/Resveratrol in the ACE2:Spike Recognition during COVID-19 Infection. A Focus on Their Potential Mechanism of Action through Computational and Biochemical Assays. Biomolecules. 2021 07; 11(7):. doi: 10.3390/biom11071048. [PMID: 34356672]
  • Tian Liu, Yuqian Liu, Lan Li, Xiaonan Liu, Zhaokuan Guo, Jian Cheng, Xiaoxi Zhu, Lina Lu, Junlin Zhang, Guanwei Fan, Nengzhong Xie, Jian Lu, Huifeng Jiang. De Novo Biosynthesis of Polydatin in Saccharomyces cerevisiae. Journal of agricultural and food chemistry. 2021 Jun; 69(21):5917-5925. doi: 10.1021/acs.jafc.1c01557. [PMID: 34018734]
  • Amir Hossein Doustimotlagh, Mahdieh Eftekhari. Glucose-6-phosphate dehydrogenase inhibitor for treatment of severe COVID-19: Polydatin. Clinical nutrition ESPEN. 2021 06; 43(?):197-199. doi: 10.1016/j.clnesp.2021.02.021. [PMID: 34024514]
  • S Montanari, L Davani, V Tumiatti, M Dimilta, A V Gaddi, A De Simone, V Andrisano. Development of an UHPLC-diode arrays detector (DAD) method for the analysis of polydatin in human plasma. Journal of pharmaceutical and biomedical analysis. 2021 May; 198(?):113985. doi: 10.1016/j.jpba.2021.113985. [PMID: 33667833]
  • Bo Sun, Yun-Long Zheng, Sheng-Kuan Yang, Jia-Ru Zhang, Xin-Yue Cheng, Reza Ghiladi, Zhuo Ma, Jun Wang, Wen-Wen Deng. One-pot method based on deep eutectic solvent for extraction and conversion of polydatin to resveratrol from Polygonum cuspidatum. Food chemistry. 2021 May; 343(?):128498. doi: 10.1016/j.foodchem.2020.128498. [PMID: 33229156]
  • Shengyu Sun, Yourui Zou, Shaocai Hao, Zhanfeng Niu, Liang Wu. Polydatin inhibits LPS-induced inflammatory response in BV2 microglia by disrupting the formation of lipid rafts. Immunopharmacology and immunotoxicology. 2021 Apr; 43(2):138-144. doi: 10.1080/08923973.2020.1867999. [PMID: 33509007]
  • Fatma Mostafa, Adel Abdel-Moneim, Manal Abdul-Hamid, Sanaa R Galaly, Hanaa M Mohamed. Polydatin and polydatin-loaded chitosan nanoparticles attenuate diabetic cardiomyopathy in rats. Journal of molecular histology. 2021 Apr; 52(2):135-152. doi: 10.1007/s10735-020-09930-4. [PMID: 33389430]
  • Zhiya Deng, Maomao Sun, Jie Wu, Haihong Fang, Shumin Cai, Sheng An, Qiaobing Huang, Zhenfeng Chen, Chenglun Wu, Ziwei Zhou, Haoran Hu, Zhenhua Zeng. SIRT1 attenuates sepsis-induced acute kidney injury via Beclin1 deacetylation-mediated autophagy activation. Cell death & disease. 2021 02; 12(2):217. doi: 10.1038/s41419-021-03508-y. [PMID: 33637691]
  • Abeer M Abd El-Hameed, Ahmed I Yousef, Sanaa M Abd El-Twab, Ahmed A G El-Shahawy, Adel Abdel-Moneim. Hepatoprotective Effects of Polydatin-Loaded Chitosan Nanoparticles in Diabetic Rats: Modulation of Glucose Metabolism, Oxidative Stress, and Inflammation Biomarkers. Biochemistry. Biokhimiia. 2021 Feb; 86(2):179-189. doi: 10.1134/s0006297921020061. [PMID: 33832416]
  • Ting-Ting Gu, Dong-Mei Zhang, Zi-Yan Wan, Tu-Shuai Li, Rui-Qing Jiao, Tian-Yu Chen, Xiao-Juan Zhao, Ling-Dong Kong. Polydatin enhances glomerular podocyte autophagy homeostasis by improving Nrf2-dependent antioxidant capacity in fructose-fed rats. Molecular and cellular endocrinology. 2021 01; 520(?):111079. doi: 10.1016/j.mce.2020.111079. [PMID: 33189863]
  • Hasnaa Ali Ebrahim, Dalia Mahmoud Abdelmonem Elsherbini. Renovation of Intestinal Barrier by Polydatin in Experimentally Induced Ulcerative Colitis: Comparative Ultrastructural Study with L-Carnosine. Cells, tissues, organs. 2021; 210(4):275-292. doi: 10.1159/000516191. [PMID: 34461611]
  • Amalia Luce, Stefania Lama, Pilar Chacon Millan, Annalisa Itro, Angelo Sangiovanni, Carlo Caputo, Pasquale Ferranti, Salvatore Cappabianca, Michele Caraglia, Paola Stiuso. Polydatin Induces Differentiation and Radiation Sensitivity in Human Osteosarcoma Cells and Parallel Secretion through Lipid Metabolite Secretion. Oxidative medicine and cellular longevity. 2021; 2021(?):3337013. doi: 10.1155/2021/3337013. [PMID: 34336090]
  • Ahmed I Yousef, Hossam H Shawki, Ahmed A El-Shahawy, Sanaa M Abd El-Twab, Adel Abdel-Moneim, Hisashi Oishi. Polydatin mitigates pancreatic β-cell damage through its antioxidant activity. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Jan; 133(?):111027. doi: 10.1016/j.biopha.2020.111027. [PMID: 33249283]
  • Zhi-Quan Chen, Xiao-Hong Sun, Xue-Juan Li, Zhan-Chi Xu, Yan Yang, Ze-Yuan Lin, Hai-Ming Xiao, Meng Zhang, Shi-Jian Quan, He-Qing Huang. Polydatin attenuates renal fibrosis in diabetic mice through regulating the Cx32-Nox4 signaling pathway. Acta pharmacologica Sinica. 2020 Dec; 41(12):1587-1596. doi: 10.1038/s41401-020-0475-6. [PMID: 32724174]
  • Massimo Bonucci, Roberto Raggi, Rosa Anna Vacca. Polydatin and its potential protective effect on COVID-19. Clinical nutrition (Edinburgh, Scotland). 2020 12; 39(12):3850-3851. doi: 10.1016/j.clnu.2020.09.052. [PMID: 33097304]
  • Osman Mutluhan Ugurel, Ozal Mutlu, Emrah Sariyer, Sinem Kocer, Erennur Ugurel, Tugba Gul Inci, Oguz Ata, Dilek Turgut-Balik. Evaluation of the potency of FDA-approved drugs on wild type and mutant SARS-CoV-2 helicase (Nsp13). International journal of biological macromolecules. 2020 Nov; 163(?):1687-1696. doi: 10.1016/j.ijbiomac.2020.09.138. [PMID: 32980406]
  • Xiaojuan Zhao, Yanzi Yang, Hanwen Yu, Wenyuan Wu, Yang Sun, Ying Pan, Lingdong Kong. Polydatin inhibits ZEB1-invoked epithelial-mesenchymal transition in fructose-induced liver fibrosis. Journal of cellular and molecular medicine. 2020 11; 24(22):13208-13222. doi: 10.1111/jcmm.15933. [PMID: 33058500]
  • Dandan Wang, Xinxin Luo, Min Wang, Kai Zhou, Zhining Xia. Selective separation and purification of polydatin by molecularly imprinted polymers from the extract of Polygoni Cuspidati Rhizoma et Radix, rats' plasma and urine. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2020 Nov; 1156(?):122307. doi: 10.1016/j.jchromb.2020.122307. [PMID: 32835909]
  • Priscilla Biswas, Cinzia Dellanoce, Alessandra Vezzoli, Simona Mrakic-Sposta, Mauro Malnati, Alberto Beretta, Roberto Accinni. Antioxidant Activity with Increased Endogenous Levels of Vitamin C, E and A Following Dietary Supplementation with a Combination of Glutathione and Resveratrol Precursors. Nutrients. 2020 Oct; 12(11):. doi: 10.3390/nu12113224. [PMID: 33105552]
  • Peng Chen, Lei Wang, Shutao Sun, Qingbing Zhou, Zehua Zeng, Mingliang Hu, Muhammad Hussain, Cheng Lu, Hongwu Du. High-throughput screening suggests glutathione synthetase as an anti-tumor target of polydatin using human proteome chip. International journal of biological macromolecules. 2020 Oct; 161(?):1230-1239. doi: 10.1016/j.ijbiomac.2020.06.061. [PMID: 32544581]
  • Luce M Mattio, Giorgia Catinella, Andrea Pinto, Sabrina Dallavalle. Natural and nature-inspired stilbenoids as antiviral agents. European journal of medicinal chemistry. 2020 Sep; 202(?):112541. doi: 10.1016/j.ejmech.2020.112541. [PMID: 32652408]
  • Peng Chen, Zehua Zeng, Hongwu Du. Establishment and validation of a drug-target microarray for SARS-CoV-2. Biochemical and biophysical research communications. 2020 09; 530(1):4-9. doi: 10.1016/j.bbrc.2020.05.217. [PMID: 32828312]
  • Parvej Ahmad, Sahir Sultan Alvi, Danish Iqbal, M Salman Khan. Insights into pharmacological mechanisms of polydatin in targeting risk factors-mediated atherosclerosis. Life sciences. 2020 Aug; 254(?):117756. doi: 10.1016/j.lfs.2020.117756. [PMID: 32389832]
  • Min Wu, Xiaoya Li, Songzi Wang, Shengjie Yang, Ran Zhao, Yanwei Xing, Longtao Liu. Polydatin for treating atherosclerotic diseases: A functional and mechanistic overview. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2020 Aug; 128(?):110308. doi: 10.1016/j.biopha.2020.110308. [PMID: 32480216]
  • Ching-Yi Cheng, Yin-Ku Lin, Shih-Chun Yang, Ahmed Alalaiwe, Chia-Jung Lin, Jia-You Fang, Chwan-Fwu Lin. Percutaneous absorption of resveratrol and its oligomers to relieve psoriasiform lesions: In silico, in vitro and in vivo evaluations. International journal of pharmaceutics. 2020 Jul; 585(?):119507. doi: 10.1016/j.ijpharm.2020.119507. [PMID: 32512223]
  • Xiaoyan Yuan, Guo Chen, Dongfeng Guo, Lei Xu, Yongfeng Gu. Polydatin Alleviates Septic Myocardial Injury by Promoting SIRT6-Mediated Autophagy. Inflammation. 2020 Jun; 43(3):785-795. doi: 10.1007/s10753-019-01153-4. [PMID: 32394287]
  • Mustafa Evcimen, Recep Aslan, Mehmet Sukru Gulay. Protective effects of polydatin and grape seed extract in rats exposed to cadmium. Drug and chemical toxicology. 2020 May; 43(3):225-233. doi: 10.1080/01480545.2018.1480629. [PMID: 29927664]
  • Manh Tuan Ha, Minji Kim, Chung Sub Kim, Se-Eun Park, Jeong Ah Kim, Mi Hee Woo, Jae Sue Choi, Byung Sun Min. Tetra-aryl cyclobutane and stilbenes from the rhizomes of Rheum undulatum and their α-glucosidase inhibitory activity: Biological evaluation, kinetic analysis, and molecular docking simulation. Bioorganic & medicinal chemistry letters. 2020 04; 30(8):127049. doi: 10.1016/j.bmcl.2020.127049. [PMID: 32111435]
  • Youguang Gao, Xingui Dai, Yunfeng Li, Guicheng Li, Xianzhong Lin, Chenmu Ai, Yuanyuan Cao, Tao Li, Bo Lin. Role of Parkin-mediated mitophagy in the protective effect of polydatin in sepsis-induced acute kidney injury. Journal of translational medicine. 2020 03; 18(1):114. doi: 10.1186/s12967-020-02283-2. [PMID: 32131850]
  • Malgorzata Latos-Brozio, Anna Masek. The Application of (+)-Catechin and Polydatin as Functional Additives for Biodegradable Polyesters. International journal of molecular sciences. 2020 Jan; 21(2):. doi: 10.3390/ijms21020414. [PMID: 31936484]
  • Hong Li, Jie Min, Yuting Chen, Hongyan Li, Yali Zhang. Polydatin attenuates orbital oxidative stress in Graves' orbitopathy through the NRF2 pathway. Chemico-biological interactions. 2020 Jan; 315(?):108894. doi: 10.1016/j.cbi.2019.108894. [PMID: 31705858]
  • Shao-Yu Guan, Kun Zhang, Xin-Shang Wang, Le Yang, Bin Feng, Dan-Dan Tian, Mei-Rong Gao, Shui-Bing Liu, An Liu, Ming-Gao Zhao. Anxiolytic effects of polydatin through the blockade of neuroinflammation in a chronic pain mouse model. Molecular pain. 2020 Jan; 16(?):1744806919900717. doi: 10.1177/1744806919900717. [PMID: 31964240]
  • Bin Han, Mengjuan Gong, Zhong Li, Yuqin Qiu, Zhongjie Zou. NMR-Based Metabonomic Study Reveals Intervention Effects of Polydatin on Potassium Oxonate-Induced Hyperuricemia in Rats. Oxidative medicine and cellular longevity. 2020; 2020(?):6943860. doi: 10.1155/2020/6943860. [PMID: 32695259]
  • Zhicheng Sun, Xiyang Wang. Protective effects of polydatin on multiple organ ischemia-reperfusion injury. Bioorganic chemistry. 2020 01; 94(?):103485. doi: 10.1016/j.bioorg.2019.103485. [PMID: 31836186]
  • Bettina Rainer, Silvia Revoltella, Fabian Mayr, Julia Moesslacher, Valentina Scalfari, Roland Kohl, Birgit Waltenberger, Konrad Pagitz, Bianka Siewert, Stefan Schwaiger, Hermann Stuppner. From bench to counter: Discovery and validation of a peony extract as tyrosinase inhibiting cosmeceutical. European journal of medicinal chemistry. 2019 Dec; 184(?):111738. doi: 10.1016/j.ejmech.2019.111738. [PMID: 31655335]
  • Taiwo O Akanbi, Susan N Marshall, Colin J Barrow. Polydatin-fatty acid conjugates are effective antioxidants for stabilizing omega 3-containing bulk fish oil and fish oil emulsions. Food chemistry. 2019 Dec; 301(?):125297. doi: 10.1016/j.foodchem.2019.125297. [PMID: 31394336]
  • Lina Gu, Jingyao Liu, Dan Xu, Ying Lu. Polydatin prevents LPS-induced acute kidney injury through inhibiting inflammatory and oxidative responses. Microbial pathogenesis. 2019 Dec; 137(?):103688. doi: 10.1016/j.micpath.2019.103688. [PMID: 31445125]
  • Bongkyun Park, Kyuhyung Jo, Tae Gu Lee, Soo-Wang Hyun, Jin Sook Kim, Chan-Sik Kim. Polydatin Inhibits NLRP3 Inflammasome in Dry Eye Disease by Attenuating Oxidative Stress and Inhibiting the NF-κB Pathway. Nutrients. 2019 Nov; 11(11):. doi: 10.3390/nu11112792. [PMID: 31731792]
  • Seyed Ali Andi, Mansour Gholami, Christopher M Ford, Fereshteh Maskani. The effect of light, phenylalanine and methyl jasmonate, alone or in combination, on growth and secondary metabolism in cell suspension cultures of Vitis vinifera. Journal of photochemistry and photobiology. B, Biology. 2019 Oct; 199(?):111625. doi: 10.1016/j.jphotobiol.2019.111625. [PMID: 31610430]
  • Weijia Zhao, Zonghan Chen, Meng Guan. Polydatin enhances the chemosensitivity of osteosarcoma cells to paclitaxel. Journal of cellular biochemistry. 2019 10; 120(10):17481-17490. doi: 10.1002/jcb.29012. [PMID: 31106479]
  • Lijuan Wang, Liji Huang, Nan Li, Junjun Miao, Wei Liu, Jiangyi Yu. Ameliorative effect of polydatin on hyperglycemia and renal injury in streptozotocin-induced diabetic rats. Cellular and molecular biology (Noisy-le-Grand, France). 2019 Sep; 65(7):55-59. doi: . [PMID: 31880518]
  • Yi Peng, Jin Xu, Yi Zeng, Long Chen, Xiao Le Xu. Polydatin attenuates atherosclerosis in apolipoprotein E-deficient mice: Role of reverse cholesterol transport. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2019 Sep; 62(?):152935. doi: 10.1016/j.phymed.2019.152935. [PMID: 31085374]
  • Raju Naini, P Pavankumar, S Prabhakar, Rama Krishna Kancha, Khareedu Venkateswara Rao, Vudem Dashavantha Reddy. Evolvement of nutraceutical onion plants engineered for resveratrol biosynthetic pathway. Plant cell reports. 2019 Sep; 38(9):1127-1137. doi: 10.1007/s00299-019-02432-y. [PMID: 31154513]
  • Xiaoting Chen, Hung Chan, Lin Zhang, Xiaodong Liu, Idy H T Ho, Xiang Zhang, Jeffery Ho, Wei Hu, Yuanyuan Tian, Shanglong Kou, Chee Sam Chan, Jun Yu, Sunny H Wong, Tony Gin, Matthew T V Chan, Xuegang Sun, William K K Wu. The phytochemical polydatin ameliorates non-alcoholic steatohepatitis by restoring lysosomal function and autophagic flux. Journal of cellular and molecular medicine. 2019 06; 23(6):4290-4300. doi: 10.1111/jcmm.14320. [PMID: 30973211]
  • Jin Tang, Yungai Li, Jianqiang Wang, Qiong Wu, Hongli Yan. Polydatin suppresses the development of lung inflammation and fibrosis by inhibiting activation of the NACHT domain-, leucine-rich repeat-, and pyd-containing protein 3 inflammasome and the nuclear factor-κB pathway after Mycoplasma pneumoniae infection. Journal of cellular biochemistry. 2019 06; 120(6):10137-10144. doi: 10.1002/jcb.28297. [PMID: 30548648]
  • Xiaodan Mei, Yuqi Wang, Jie Li, Zihan Liu, Shuang Lang, Wenzhu Ouyang, Jiayu Zhang. Comprehensive metabolism study of polydatin in rat plasma and urine using ultra-high performance liquid chromatography coupled with high-resolution mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2019 Jun; 1117(?):22-35. doi: 10.1016/j.jchromb.2019.04.005. [PMID: 30991203]
  • Dina A Hanna, Marwa M Khalaf, Ali A Abo-Saif. Polydatin protects against ovalbumin-induced bronchial asthma in rats; involvement of urocortin and surfactant-D expression. Immunopharmacology and immunotoxicology. 2019 Jun; 41(3):403-412. doi: 10.1080/08923973.2018.1536985. [PMID: 30422021]
  • Jungeun Kim, Jisun Oh, Janice N Averilla, Hyo Jung Kim, Jae-Sik Kim, Jong-Sang Kim. Grape Peel Extract and Resveratrol Inhibit Wrinkle Formation in Mice Model Through Activation of Nrf2/HO-1 Signaling Pathway. Journal of food science. 2019 Jun; 84(6):1600-1608. doi: 10.1111/1750-3841.14643. [PMID: 31132143]
  • R Yao, C B Wong, K Nakamura, E Mitsuyama, A Tanaka, T Kuhara, T Odamaki, J-Z Xiao. Bifidobacterium breve MCC1274 with glycosidic activity enhances in vivo isoflavone bioavailability. Beneficial microbes. 2019 May; 10(5):521-531. doi: 10.3920/bm2018.0179. [PMID: 31090459]
  • Tao Zhang, Xinying Zhu, Haichong Wu, Kangfeng Jiang, Gan Zhao, Aftab Shaukat, Ganzhen Deng, Changwei Qiu. Targeting the ROS/PI3K/AKT/HIF-1α/HK2 axis of breast cancer cells: Combined administration of Polydatin and 2-Deoxy-d-glucose. Journal of cellular and molecular medicine. 2019 05; 23(5):3711-3723. doi: 10.1111/jcmm.14276. [PMID: 30920152]
  • Suat Sari, Burak Barut, Arzu Özel, Ayşe Kuruüzüm-Uz, Didem Şöhretoğlu. Tyrosinase and α-glucosidase inhibitory potential of compounds isolated from Quercus coccifera bark: In vitro and in silico perspectives. Bioorganic chemistry. 2019 05; 86(?):296-304. doi: 10.1016/j.bioorg.2019.02.015. [PMID: 30738329]
  • Meiying Su, Chao Dong, Jiyun Wan, Maojin Zhou. Pharmacokinetics, tissue distribution and excretion study of trans-resveratrol-3-O-glucoside and its two metabolites in rats. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2019 May; 58(?):152882. doi: 10.1016/j.phymed.2019.152882. [PMID: 30901659]
  • Xiao-Jun Chen, Ying-Shan Shen, Min-Cong He, Fan Yang, Peng Yang, Feng-Xiang Pang, Wei He, Yan-Ming Cao, Qiu-Shi Wei. Polydatin promotes the osteogenic differentiation of human bone mesenchymal stem cells by activating the BMP2-Wnt/β-catenin signaling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2019 Apr; 112(?):108746. doi: 10.1016/j.biopha.2019.108746. [PMID: 30970530]
  • Hao Zhang, Yongchun Chen, Zhipeng Pei, Huanhuan Gao, Wenwen Shi, Mingxue Sun, Qingqiang Xu, Jie Zhao, Wenqi Meng, Kai Xiao. Protective effects of polydatin against sulfur mustard-induced hepatic injury. Toxicology and applied pharmacology. 2019 03; 367(?):1-11. doi: 10.1016/j.taap.2019.01.013. [PMID: 30677423]
  • Guo Chen, Guorong Liu, Dawei Cao, Mingming Jin, Dongfeng Guo, Xiaoyan Yuan. Polydatin protects against acute myocardial infarction-induced cardiac damage by activation of Nrf2/HO-1 signaling. Journal of natural medicines. 2019 Jan; 73(1):85-92. doi: 10.1007/s11418-018-1241-7. [PMID: 30191382]
  • Li Zheng, Jiayuan Wu, Juanfen Mo, Li Guo, Xiaoyan Wu, Yi Bao. Polydatin Inhibits Adipose Tissue Inflammation and Ameliorates Lipid Metabolism in High-Fat-Fed Mice. BioMed research international. 2019; 2019(?):7196535. doi: 10.1155/2019/7196535. [PMID: 31828124]
  • Cong Ma, Bo Wen, Qin Zhang, Peipei Shao, Wen Gu, Kun Qu, Yang Shi, Bei Wang. Polydatin Regulates the Apoptosis and Autophagy of Fibroblasts Obtained from Patients with Ankylosing Spondylitis. Biological & pharmaceutical bulletin. 2019 Jan; 42(1):50-56. doi: 10.1248/bpb.b18-00522. [PMID: 30333377]
  • Pan Liao, Yi He, Fangyuan Yang, Guihu Luo, Jian Zhuang, Zeqing Zhai, Lili Zhuang, Zhuomiao Lin, Jiehuang Zheng, Erwei Sun. Polydatin effectively attenuates disease activity in lupus-prone mouse models by blocking ROS-mediated NET formation. Arthritis research & therapy. 2018 Nov; 20(1):254. doi: 10.1186/s13075-018-1749-y. [PMID: 30419963]
  • Li Li, Chen Shen, Ya-Xuan Huang, Ya-Nan Li, Xiu-Feng Liu, Xu-Ming Liu, Ji-Hua Liu. A New Strategy for Rapidly Screening Natural Inhibitors Targeting the PCSK9/LDLR Interaction In Vitro. Molecules (Basel, Switzerland). 2018 Sep; 23(9):. doi: 10.3390/molecules23092397. [PMID: 30235833]