alpha-Hydroxyisobutyric acid (BioDeep_00000003200)

 

Secondary id: BioDeep_00000171435, BioDeep_00000398021, BioDeep_00000398294, BioDeep_00000419029

human metabolite PANOMIX_OTCML-2023 blood metabolite BioNovoGene_Lab2019


代谢物信息卡片


alpha-Hydroxy-alpha-methylpropanoic acid

化学式: C4H8O3 (104.0473)
中文名称: 2-甲基-2-羟基丙酸, α-羟基异丁酸, 2-羟基异丁酸
谱图信息: 最多检出来源 Homo sapiens(plant) 11.06%

Reviewed

Last reviewed on 2024-09-13.

Cite this Page

alpha-Hydroxyisobutyric acid. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/alpha-hydroxyisobutyric_acid (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000003200). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CC(C)(C(=O)O)O
InChI: InChI=1S/C4H8O3/c1-4(2,7)3(5)6/h7H,1-2H3,(H,5,6)

描述信息

Alpha-Hydroxyisobutyric acid is a metabolite of methyl tert-butyl ether (MTBE). MTBE may be obtained through environmental exposure. MTBE is rapidly eliminated from the body, mainly through expired air as the unchanged compound. MTBE is to some extent metabolised to t-butyl alcohol (TBA) and formaldehyde and oxidised to 2-methyl-1,2-propanediol and a-hydroxy isobuturic acid. Alpha-Hydroxyisobutyric acid has been used as an arial bactericide. [HMDB]
alpha-Hydroxyisobutyric acid is a metabolite of methyl tert-butyl ether (MTBE). MTBE may be obtained through environmental exposure. MTBE is rapidly eliminated from the body, mainly through expired air as the unchanged compound. MTBE is to some extent metabolized to t-butyl alcohol (TBA) and formaldehyde and oxidized to 2-methyl-1,2-propanediol and alpha-hydroxyisobutyric acid. alpha-Hydroxyisobutyric acid has been used as an aerial bactericide.
2-Hydroxyisobutyric acid is an endogenous metabolite.

同义名列表

58 个代谢物同义名

alpha-Hydroxy-alpha-methylpropanoic acid; alpha-Hydroxy-alpha-methylpropionic acid; alpha-Hydroxy-alpha-methylpropanoate; alpha-Hydroxy-alpha-methylpropionate; 2-Hydroxyisobutyric acid, lead salt; Acide 2-hydroxy-2-methylpropanoique; Acido 2-hidroxi-2-metilpropionico; a-Hydroxy-a-methylpropionic acid; 2-Hydroxy-2-methylpropionic acid; Α-hydroxy-α-methylpropanoic acid; a-Hydroxy-a-methylpropanoic acid; 2-Methyl-2-hydroxypropanoic acid; Α-hydroxy-α-methylpropionic acid; 2-Hydroxy-2-methylpropanoic acid; 2-Hydroxy-2-methylpropionsaeure; 2-Methyl-2-hydroxypropionsaeure; Lead 2-hydroxyisobutyric acid; alpha-Hydroxyisobutanoic acid; a-Hydroxy-a-methylpropanoate; Α-hydroxy-α-methylpropanoate; Α-hydroxy-α-methylpropionate; a-Hydroxy-a-methylpropionate; 2-Methyl-2-hydroxypropanoate; 2-Hydroxy-2-methylpropanoate; alpha-Hydroxyisobutyric acid; 2-Hydroxy-2-methylpropionate; Hydroxydimethylacetic acid; alpha-Hydroxyisobutanoate; Α-hydroxyisobutanoic acid; a-Hydroxy-isobutyric acid; alpha-Hydroxy-isobutyrate; a-Hydroxyisobutanoic acid; Α-hydroxy-isobutyric acid; Α-hydroxyisobutyric acid; 2-HYDROXYISOBUTYRIC ACID; alpha-Hydroxyisobutyrate; a-Hydroxyisobutyric acid; Hydroxydimethylacetate; Α-hydroxy-isobutyrate; a-Hydroxyisobutanoate; L-2-Methyllactic acid; a-Hydroxy-isobutyrate; Α-hydroxyisobutanoate; Α-hydroxyisobutyrate; 2-Hydroxyisobutyrate; a-Hydroxyisobutyrate; 2-Methyllactic acid; Hydroxyisobutyrate; L-2-Methyllactate; 2-Methyllactate; Acetonic acid; (CH3)2cohcooh; alpha-HIB; Acetonate; a-HIB; HIBA; 2-Hydroxyisobutyric acid; Alpha-Hydroxyisobutyric acid



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

7 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 ADIG, APOE, BCL2, CST3, MAPK14, MMUT, NLRP3, NPM1, SRMS, TBP, TXNIP, VIM
Peripheral membrane protein 1 RDX
Endosome membrane 1 TF
Endoplasmic reticulum membrane 1 BCL2
Nucleus 7 ADIG, APOE, BCL2, MAPK14, NLRP3, NPM1, TBP
cytosol 7 BCL2, MAPK14, NLRP3, NPM1, SRMS, TXNIP, VIM
dendrite 1 APOE
phagocytic vesicle 1 VIM
centrosome 1 NPM1
nucleoplasm 4 CD2, MAPK14, NPM1, TBP
Cell membrane 3 CD2, RDX, VIM
Cytoplasmic side 1 RDX
Cleavage furrow 1 RDX
lamellipodium 1 RDX
Multi-pass membrane protein 1 CACNA1I
Golgi apparatus membrane 1 NLRP3
cell surface 2 CD2, TF
glutamatergic synapse 2 APOE, MAPK14
Golgi apparatus 4 APOE, CD2, CST3, STC2
Golgi membrane 2 INS, NLRP3
neuronal cell body 1 APOE
Cytoplasm, cytosol 1 NLRP3
plasma membrane 9 APOE, CACNA1I, CD2, CST3, RDX, SRMS, TF, TNFRSF17, VIM
Membrane 8 ADIG, APOE, BCL2, CACNA1I, NLRP3, NPM1, RDX, TNFRSF17
apical plasma membrane 2 RDX, TF
axon 1 VIM
extracellular exosome 6 APOE, BMP3, CST3, RDX, TF, VIM
endoplasmic reticulum 5 APOE, BCL2, CST3, NLRP3, STC2
extracellular space 7 APOE, BMP3, CST3, INS, RDX, STC2, TF
perinuclear region of cytoplasm 2 STC2, TF
adherens junction 1 RDX
mitochondrion 4 BCL2, MAPK14, MMUT, NLRP3
protein-containing complex 4 BCL2, CD2, NPM1, TBP
filopodium 1 RDX
Single-pass type I membrane protein 1 CD2
Secreted 8 ADIG, APOE, BMP3, CST3, INS, NLRP3, STC2, TF
extracellular region 9 ADIG, APOE, BMP3, CD2, CST3, INS, MAPK14, NLRP3, TF
cytoplasmic side of plasma membrane 1 CD2
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 2 ADIG, BCL2
mitochondrial outer membrane 1 BCL2
basal part of cell 1 TF
Mitochondrion matrix 1 MMUT
mitochondrial matrix 1 MMUT
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 NPM1
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 1 CD2
Endosome, multivesicular body 1 APOE
Extracellular vesicle 1 APOE
Secreted, extracellular space, extracellular matrix 1 APOE
chylomicron 1 APOE
high-density lipoprotein particle 1 APOE
low-density lipoprotein particle 1 APOE
multivesicular body 1 APOE
very-low-density lipoprotein particle 1 APOE
T-tubule 1 RDX
cytoplasmic vesicle 1 TF
nucleolus 1 NPM1
midbody 1 RDX
Early endosome 2 APOE, TF
apical part of cell 1 RDX
cell-cell junction 1 CD2
clathrin-coated pit 1 TF
recycling endosome 1 TF
vesicle 2 CST3, TF
pore complex 1 BCL2
Cytoplasm, cytoskeleton 2 RDX, VIM
focal adhesion 3 NPM1, RDX, VIM
extracellular matrix 1 APOE
Peroxisome 1 VIM
collagen-containing extracellular matrix 1 APOE
intermediate filament 1 VIM
nuclear speck 1 MAPK14
Cytoplasm, cytoskeleton, microtubule organizing center 1 NLRP3
Inflammasome 1 NLRP3
interphase microtubule organizing center 1 NLRP3
NLRP3 inflammasome complex 1 NLRP3
Late endosome 1 TF
neuron projection 1 VIM
chromatin 1 TBP
cell leading edge 1 VIM
cell projection 1 RDX
cell periphery 1 RDX
cytoskeleton 2 RDX, VIM
Secreted, extracellular space 1 APOE
Nucleus, nucleolus 1 NPM1
spindle pole 1 MAPK14
blood microparticle 2 APOE, TF
Endomembrane system 2 NLRP3, TNFRSF17
endosome lumen 1 INS
microvillus 1 RDX
Lipid droplet 1 ADIG
microtubule organizing center 2 NLRP3, VIM
Cell projection, stereocilium 1 RDX
Cell projection, microvillus 1 RDX
female germ cell nucleus 1 TBP
Nucleus, nucleoplasm 1 NPM1
Melanosome 1 APOE
euchromatin 1 TBP
myelin sheath 1 BCL2
intermediate filament cytoskeleton 1 VIM
basal plasma membrane 1 TF
ficolin-1-rich granule lumen 2 CST3, MAPK14
secretory granule lumen 3 INS, MAPK14, TF
HFE-transferrin receptor complex 1 TF
Golgi lumen 1 INS
endoplasmic reticulum lumen 5 APOE, CST3, INS, STC2, TF
nuclear matrix 1 VIM
male germ cell nucleus 1 TBP
transcription factor TFIID complex 1 TBP
cortical actin cytoskeleton 1 RDX
voltage-gated calcium channel complex 1 CACNA1I
tertiary granule lumen 1 CST3
endocytic vesicle 1 TF
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
Nucleus matrix 1 VIM
cell tip 1 RDX
clathrin-coated endocytic vesicle membrane 2 APOE, TF
spindle pole centrosome 1 NPM1
ribonucleoprotein complex 1 NPM1
synaptic cleft 1 APOE
protein-DNA complex 1 NPM1
female pronucleus 1 TBP
male pronucleus 1 TBP
granular component 1 NPM1
vesicle coat 1 TF
discoidal high-density lipoprotein particle 1 APOE
endocytic vesicle lumen 1 APOE
chylomicron remnant 1 APOE
intermediate-density lipoprotein particle 1 APOE
lipoprotein particle 1 APOE
multivesicular body, internal vesicle 1 APOE
BAD-BCL-2 complex 1 BCL2
RNA polymerase transcription factor SL1 complex 1 TBP
transcription factor TFIIA complex 1 TBP
stereocilium base 1 RDX
dense body 1 TF


文献列表

  • Xiaoyang Chen, Xiabing Li, Pingping Li, Xiaolin Chen, Hao Liu, Junbin Huang, Chaoxi Luo, Tom Hsiang, Lu Zheng. Comprehensive identification of lysine 2-hydroxyisobutyrylated proteins in Ustilaginoidea virens reveals the involvement of lysine 2-hydroxyisobutyrylation in fungal virulence. Journal of integrative plant biology. 2021 Feb; 63(2):409-425. doi: 10.1111/jipb.13066. [PMID: 33427395]
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