1-Methylhistamine (BioDeep_00000003010)

 

Secondary id: BioDeep_00000398679

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite


代谢物信息卡片


2-(1-methyl-1H-imidazol-4-yl)ethan-1-amine

化学式: C6H11N3 (125.0953)
中文名称: 2-(1-甲基-1H-咪唑-4-基)乙-1-胺
谱图信息: 最多检出来源 Homo sapiens(blood) 30.9%

Reviewed

Last reviewed on 2024-09-13.

Cite this Page

1-Methylhistamine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/1-methylhistamine (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000003010). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CN1C=C(N=C1)CCN
InChI: InChI=1/C6H11N3/c1-9-4-6(2-3-7)8-5-9/h4-5H,2-3,7H2,1H3

描述信息

1-Methylhistamine, also known as H137, belongs to the class of organic compounds known as 2-arylethylamines. These are primary amines that have the general formula RCCNH2, where R is an organic group. 1-Methylhistamine exists in all living organisms, ranging from bacteria to humans. Within humans, 1-methylhistamine participates in a number of enzymatic reactions. In particular, S-adenosylhomocysteine and 1-methylhistamine can be biosynthesized from S-adenosylmethionine and histamine; which is mediated by the enzyme histamine N-methyltransferase. In addition, 1-methylhistamine can be converted into methylimidazole acetaldehyde through its interaction with the enzyme amine oxidase [flavin-containing] a. In humans, 1-methylhistamine is involved in histidine metabolism. 1-Methylhistamine is a potentially toxic compound.
1-Methylhistamine is a histamine metabolite. It is a product of histamine 1-methyltransferase [EC 2.1.1.8] in the pathway histidine metabolism (KEGG). [HMDB]
Acquisition and generation of the data is financially supported in part by CREST/JST.
D004791 - Enzyme Inhibitors

同义名列表

32 个代谢物同义名

2-(1-methyl-1H-imidazol-4-yl)ethan-1-amine; 2-(1-Methyl-1H-imidazol-4-yl)ethylamine; 2-(1-Methyl-1H-imidazol-4-yl)ethanamine; 4-(1-Aminoethyl)-1-methyl-1H-imidazole; 1-Methyl-4-(beta-aminoethyl)imidazole; tele-Methylhistamine dihydrochloride; 4-(2-Aminoethyl)-1-methyl-imidazole; 1-Methyl-4-(2-aminoethyl)imidazole; 1-Methyl-4-(b-aminoethyl)imidazole; 4-(2-Aminoethyl)-1-methylimidazole; 1-Methyl-1H-imidazole-4-ethanamine; 1-Methylhistamine dihydrochloride; N-Telle-methylhistamine; N-tele-Methylhistamine; N-tele Methylhistamine; N( 1)-Methylhistamine; Ntau-methylhistamine; tele-Methylhistamine; N(1)-Methylhistamine; N(T)-Methylhistamine; 1-Methyl-4-histamine; 1,4-Methylhistamine; N1-Methylhistamine; NT-Methylhistamine; Nτ-methylhistamine; N-Methylhistamine; 3-Methylhistamine; 1-Methylhistamine; Methylhistamine; H137; N-Methylhistamine; 1-Methylhistamine



数据库引用编号

23 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(4)

BioCyc(0)

PlantCyc(0)

代谢反应

17 个相关的代谢反应过程信息。

Reactome(8)

BioCyc(0)

WikiPathways(1)

Plant Reactome(0)

INOH(1)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(7)

PharmGKB(0)

21 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 3 HDC, HNMT, HTT
Peripheral membrane protein 1 AOC1
Endosome membrane 2 CD63, HTT
Nucleus 2 HDC, HTT
autophagosome 2 HTT, MAP1LC3A
cytosol 5 HDC, HNMT, HTT, LEP, MAP1LC3A
dendrite 3 HRH2, HTT, MAOB
centrosome 1 HNMT
nucleoplasm 4 ATP2B1, CD63, HNMT, HTT
Cell membrane 6 AOC1, ATP2B1, CD63, ENPP3, HRH2, HTT
Lipid-anchor 1 MAP1LC3A
Cytoplasmic side 1 MAOB
Multi-pass membrane protein 4 ATP2B1, CD63, HRH2, HTT
Synapse 5 ATP2B1, CRH, HCRT, HRH2, HTT
cell surface 1 CD63
glutamatergic synapse 2 ATP2B1, MAP1LC3A
Golgi apparatus 1 HTT
Golgi membrane 1 INS
lysosomal membrane 1 CD63
neuronal cell body 1 MAOB
postsynapse 1 HCRT
presynaptic membrane 2 ATP2B1, HTT
synaptic vesicle 1 HCRT
plasma membrane 8 AOC1, ATP2B1, CD63, ENPP3, HRH2, HTT, IFNLR1, IGHE
synaptic vesicle membrane 1 ATP2B1
Membrane 4 ATP2B1, CD63, HDC, IFNLR1
apical plasma membrane 1 ENPP3
axon 1 HTT
basolateral plasma membrane 1 ATP2B1
extracellular exosome 5 AOC1, ATP2B1, CD63, ENPP3, HNMT
Lysosome membrane 1 CD63
endoplasmic reticulum 1 HTT
extracellular space 10 AOC1, CD63, CRH, IFNA1, IGHE, IL4, IL6, INS, LEP, TPSAB1
perinuclear region of cytoplasm 3 ENPP3, HCRT, HTT
bicellular tight junction 1 AOC1
mitochondrion 1 MAOB
protein-containing complex 1 HTT
intracellular membrane-bounded organelle 3 ATP2B1, CD63, MAP1LC3A
Single-pass type I membrane protein 2 IFNLR1, IGHE
Secreted 7 CRH, ENPP3, IFNA1, IL4, IL6, INS, LEP
extracellular region 10 AOC1, CD63, CRH, HCRT, IGHE, IL4, IL6, INS, LEP, TPSAB1
Mitochondrion outer membrane 1 MAOB
mitochondrial outer membrane 1 MAOB
Extracellular side 1 AOC1
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
external side of plasma membrane 1 ENPP3
varicosity 1 CRH
Endosome, multivesicular body 1 CD63
multivesicular body 1 CD63
neuronal dense core vesicle lumen 2 CRH, HCRT
perikaryon 1 CRH
cytoplasmic vesicle 1 HCRT
Early endosome 1 HTT
Single-pass type II membrane protein 1 ENPP3
postsynaptic membrane 1 HTT
Apical cell membrane 1 ENPP3
Membrane raft 1 HTT
Cell junction, focal adhesion 1 HTT
Cytoplasm, cytoskeleton 1 MAP1LC3A
focal adhesion 1 HTT
microtubule 1 MAP1LC3A
Peroxisome 1 AOC1
lateral plasma membrane 1 ATP2B1
Late endosome 2 HTT, MAP1LC3A
Cell projection, neuron projection 1 HTT
neuron projection 1 HTT
IgE immunoglobulin complex 1 IGHE
Cytoplasmic vesicle, autophagosome membrane 1 MAP1LC3A
Late endosome membrane 1 CD63
autophagosome membrane 1 MAP1LC3A
cell projection 1 ATP2B1
centriole 1 HTT
Secreted, extracellular space 1 AOC1
Basolateral cell membrane 1 ATP2B1
[Isoform 2]: Cell membrane 1 IGHE
organelle membrane 1 MAP1LC3A
Endomembrane system 2 HTT, MAP1LC3A
endosome lumen 2 CD63, INS
Cytoplasmic vesicle membrane 1 HTT
Melanosome 1 CD63
Presynaptic cell membrane 1 ATP2B1
multivesicular body membrane 1 CD63
platelet dense granule membrane 1 CD63
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 IL6, INS
specific granule lumen 1 AOC1
transport vesicle 1 INS
azurophil granule membrane 1 CD63
Secreted, extracellular exosome 1 CD63
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
mitochondrial envelope 1 MAOB
immunological synapse 1 ATP2B1
Single-pass type IV membrane protein 1 MAOB
Rough endoplasmic reticulum 1 HCRT
postsynaptic cytosol 1 HTT
presynaptic cytosol 1 HTT
[Isoform 3]: Cell membrane 1 IGHE
[Isoform 1]: Secreted 1 IGHE
IgE B cell receptor complex 1 IGHE
immunoglobulin complex, circulating 1 IGHE
multivesicular body, internal vesicle 1 CD63
Autolysosome 1 MAP1LC3A
inclusion body 1 HTT
interleukin-6 receptor complex 1 IL6
photoreceptor ribbon synapse 1 ATP2B1
serotonergic synapse 1 HTT
[Huntingtin]: Cytoplasm 1 HTT
[Huntingtin, myristoylated N-terminal fragment]: Cytoplasmic vesicle, autophagosome 1 HTT
interleukin-28 receptor complex 1 IFNLR1


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