Shikimic acid (BioDeep_00000000282)

 

Secondary id: BioDeep_00000398591, BioDeep_00000413238

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite BioNovoGene_Lab2019


代谢物信息卡片


Shikimic acid [3R-(3alpha,4alpha,5beta)]-3,4,5-Trihydroxy-1-cyclohexene-1-carboxylic acid

化学式: C7H10O5 (174.0528)
中文名称: 莽草酸, (-)-莽草酸
谱图信息: 最多检出来源 Homo sapiens(blood) 19.75%

分子结构信息

SMILES: C1=C(C[C@H]([C@@H]([C@@H]1O)O)O)C(=O)O
InChI: InChI=1S/C7H10O5/c8-4-1-3(7(11)12)2-5(9)6(4)10/h1,4-6,8-10H,2H2,(H,11,12)/t4-,5-,6-/m1/s1

描述信息

Shikimic acid is a cyclohexenecarboxylic acid that is cyclohex-1-ene-1-carboxylic acid substituted by hydroxy groups at positions 3, 4 and 5 (the 3R,4S,5R stereoisomer). It is an intermediate metabolite in plants and microorganisms. It has a role as an Escherichia coli metabolite, a Saccharomyces cerevisiae metabolite and a plant metabolite. It is a cyclohexenecarboxylic acid, a hydroxy monocarboxylic acid and an alpha,beta-unsaturated monocarboxylic acid. It is a conjugate acid of a shikimate.
Shikimic acid is a metabolite found in or produced by Escherichia coli (strain K12, MG1655).
Shikimic acid is a natural product found in Quercus mongolica, Populus tremula, and other organisms with data available.
Shikimic acid is a metabolite found in or produced by Saccharomyces cerevisiae.
A tri-hydroxy cyclohexene carboxylic acid important in biosynthesis of so many compounds that the shikimate pathway is named after it.
Shikimic acid, more commonly known as its anionic form shikimate, is a cyclohexene, a cyclitol and a cyclohexanecarboxylic acid. It is an important biochemical intermediate in plants and microorganisms. Its name comes from the Japanese flower shikimi (the Japanese star anise, Illicium anisatum), from which it was first isolated. Shikimic acid is a precursor for: the aromatic amino acids phenylalanine and tyrosine; indole, indole derivatives and tryptophan; many alkaloids and other aromatic metabolites; tannins; and lignin. In pharmaceutical industry, shikimic acid from chinese star anise is used as a base material for production of Tamiflu (oseltamivir). Although shikimic acid is present in most autotrophic organisms, it is a biosynthetic intermediate and generally found in very low concentrations.
A cyclohexenecarboxylic acid that is cyclohex-1-ene-1-carboxylic acid substituted by hydroxy groups at positions 3, 4 and 5 (the 3R,4S,5R stereoisomer). It is an intermediate metabolite in plants and microorganisms.
Acquisition and generation of the data is financially supported in part by CREST/JST.
CONFIDENCE standard compound; INTERNAL_ID 175
KEIO_ID S012
Shikimic acid is a key metabolic intermediate of the aromatic amino acid biosynthesis pathway, found in microbes and plants.
Shikimic acid is a key metabolic intermediate of the aromatic amino acid biosynthesis pathway, found in microbes and plants.

同义名列表

81 个代谢物同义名

Shikimic acid [3R-(3alpha,4alpha,5beta)]-3,4,5-Trihydroxy-1-cyclohexene-1-carboxylic acid; InChI=1/C7H10O5/c8-4-1-3(7(11)12)2-5(9)6(4)10/h1,4-6,8-10H,2H2,(H,11,12)/t4-,5-,6-/m1/s; 1-Cyclohexene-1-carboxylic acid, 3,4,5-trihydroxy-, (3R-(3alpha,4alpha,5beta))- (9CI); 1-Cyclohexene-1-carboxylic acid, 3,4,5-trihydroxy-, (3R-(3alpha,4alpha,5beta))-; 1-Cyclohexene-1-carboxylic acid, 3,4,5-trihydroxy-, (3R-(3alpha,4alpha,5beta)); [3R-(3 alpha,4 alpha,5 beta)]-3,4,5-Trihydroxy-1-cyclohexene-1-carboxylic acid; [3R-(3alpha,4alpha,5beta)]-3,4,5-Trihydroxy-1-cyclohexene-1-carboxylic acid; [3R-(3alpha,4alpha,5beta)]-3,4,5-Trihydroxy-1-cyclohexene-1-carboxylate; 1-Cyclohexene-1-carboxylic acid, 3,4,5-trihydroxy-, (3R,4S,5R)- (9CI); SHIKIMIC ACID (CONSTITUENT OF CRANBERRY LIQUID PREPARATION) [DSC]; [3R-(3Α,4α,5β)]-3,4,5-trihydroxy-1-cyclohexene-1-carboxylic acid; [3R-(3a,4a,5b)]-3,4,5-Trihydroxy-1-cyclohexene-1-carboxylic acid; 1-cyclohexene-1-carboxylic acid, 3,4,5-trihydroxy-, (3R,4S,5R)-; (3R,4S,5R)-(-)-3,4,5-Trihydroxy-1-cyclohexene-1-carboxylic Acid; 3alpha,4alpha,5beta-Trihydroxy-1-cyclohexene-1-carboxylic acid; [3R-(3a,4a,5b)]-3,4,5-Trihydroxy-1-cyclohexene-1-carboxylate; [3R-(3Α,4α,5β)]-3,4,5-trihydroxy-1-cyclohexene-1-carboxylate; (3R,4S,5R)-(-)-3,4,5-Trihydroxy-1-cyclohexenecarboxylic acid; (3r,4s,5r)-3,4,5-trihydroxy-1-cyclohexene-1-carboxylic acid; (3R,4S,5R)-3,4,5-TRIHYDROXYCYCLOHEX-1-ENE-1-CARBOXYLIC ACID; 3alpha,4alpha,5beta-Trihydroxy-1-cyclohexene-1-carboxylate; (3R,4S,5R)-3,4,5-trihydroxycyclohexene-1-carboxylic acid; (4S,3R,5R)-3,4,5-trihydroxycyclohex-1-enecarboxylic acid; (3R,4S,5R)-3,4,5-Trihydroxycyclohex-1-enecarboxylic acid; (3R,4S,5R)-3,4,5-trihydroxycyclohexene-1-carboxylicacid; (-)-3,4,5-Trihydroxy-1-cyclohexene-1-carboxylic acid; HYDROTRIS(3-PHENYLPYRAZOL-1-YL)BORATE THALLIUM SALT; 3Α,4α,5β-trihydroxy-1-cyclohexene-1-carboxylic acid; 3a,4a,5b-Trihydroxy-1-cyclohexene-1-carboxylic acid; 1-cyclohexene-1-carboxylic acid, 3,4,5-trihydroxy-; 3Α,4α,5β-trihydroxy-1-cyclohexene-1-carboxylate; 3a,4a,5b-Trihydroxy-1-cyclohexene-1-carboxylate; 3,4,5-Trihydroxycyclohex-1-enecarboxylic acid; 3,4,5-Trihydroxy-1-cyclohexenecarboxylic acid; 3,4,5-Trihydroxy-1-cyclohexenecarboxylate; B1A53F8A-8664-405D-8370-A9785ADD2D0B; Shikimic acid, analytical standard; Bracken fern toxic component; Shikimic acid, >=99\\%; SHIKIMIC ACID [IARC]; SHIKIMIC ACID [HSDB]; SHIKIMIC ACID [INCI]; L-(-)-SHIKIMIC ACID; SHIKIMIC ACID [MI]; (-)-Shikimic acid; Spectrum3_001541; Spectrum5_000386; Spectrum4_001853; Spectrum2_001508; Shikimatic acid; L-Shikimic acid; UNII-29MS2WI2NU; Acid, Shikimic; (-)-Shikimate; DivK1c_006584; MEGxp0_001939; Shikimic acid; Skikimic acid; Shicimic Acid; KBio2_004280; KBio3_002482; KBio1_001528; ShikimicAcid; KBio2_006848; KBio2_001712; L-Shikimate; SMP1_000326; 29MS2WI2NU; Skikimate; shikimate; VEROCHIC; Shikimic; C7H10O5; 2aay; 1we2; 2aa9; 4guj; (-)Shikimic acid; Shikimic acid; Shikimic acid; Shikimate



数据库引用编号

42 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(2)

BioCyc(0)

PlantCyc(0)

代谢反应

483 个相关的代谢反应过程信息。

Reactome(2)

BioCyc(0)

WikiPathways(0)

Plant Reactome(474)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(7)

PharmGKB(0)

90 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 ARHGAP45, CAT, G6PD, PKM, TYR, XDH
Peripheral membrane protein 4 CYP1B1, G6PD, HSD17B6, SDHA
Endoplasmic reticulum membrane 3 CYP1B1, SFTPD, TKT
Nucleus 2 MYB, PKM
cytosol 8 ARHGAP45, CAT, G6PD, MYB, PKM, TAT, TKT, XDH
nuclear body 1 TKT
nucleoplasm 2 MYB, TKT
RNA polymerase II transcription regulator complex 1 MYB
Cell membrane 2 TKT, TNF
ruffle membrane 1 ARHGAP45
Early endosome membrane 1 HSD17B6
Multi-pass membrane protein 1 SLC45A2
cell surface 1 TNF
lysosomal membrane 1 GAA
mitochondrial inner membrane 1 SDHA
neuronal cell body 1 TNF
Cytoplasm, cytosol 1 G6PD
Cytoplasmic vesicle, secretory vesicle 1 NTS
Lysosome 3 GAA, SFTPD, TYR
plasma membrane 4 ARHGAP45, GAA, TKT, TNF
Membrane 7 ARHGAP45, CAT, CYP1B1, G6PD, GAA, MYB, SLC45A2
apical plasma membrane 1 TKT
extracellular exosome 5 CAT, G6PD, GAA, PKM, TKT
Lysosome membrane 1 GAA
Lumenal side 1 HSD17B6
endoplasmic reticulum 1 HSD17B6
extracellular space 3 SFTPD, TNF, XDH
lysosomal lumen 1 GAA
perinuclear region of cytoplasm 1 TYR
mitochondrion 4 CAT, CYP1B1, PKM, SDHA
protein-containing complex 1 CAT
intracellular membrane-bounded organelle 7 CAT, CYP1B1, G6PD, GAA, HSD17B6, NTS, TYR
Microsome membrane 2 CYP1B1, HSD17B6
Single-pass type I membrane protein 2 TKT, TYR
Secreted 2 GAA, NTS
extracellular region 8 ARHGAP45, CAT, GAA, GALP, NTS, PKM, SFTPD, TNF
cytoplasmic side of plasma membrane 1 G6PD
mitochondrial matrix 2 CAT, SDHA
centriolar satellite 1 G6PD
external side of plasma membrane 1 TNF
Extracellular vesicle 1 PKM
multivesicular body 1 SFTPD
actin cytoskeleton 1 TKT
nucleolus 1 SDHA
Melanosome membrane 2 SLC45A2, TYR
Golgi-associated vesicle 1 TYR
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 2 PKM, TKT
Cell projection, ruffle membrane 1 ARHGAP45
Mitochondrion inner membrane 1 SDHA
Matrix side 1 SDHA
Membrane raft 1 TNF
focal adhesion 2 CAT, TKT
Peroxisome 3 CAT, TKT, XDH
collagen trimer 1 SFTPD
sarcoplasmic reticulum 1 XDH
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 1 PKM
receptor complex 1 TKT
cilium 1 PKM
phagocytic cup 1 TNF
tertiary granule membrane 1 GAA
Melanosome 1 TYR
ficolin-1-rich granule lumen 2 CAT, PKM
secretory granule lumen 3 ARHGAP45, CAT, PKM
nuclear matrix 1 MYB
axon terminus 1 NTS
endocytic vesicle 1 SFTPD
transport vesicle 1 NTS
azurophil granule membrane 1 GAA
azurophil granule lumen 1 ARHGAP45
respiratory chain complex II (succinate dehydrogenase) 1 SDHA
clathrin-coated endocytic vesicle 1 SFTPD
ficolin-1-rich granule membrane 1 GAA
Rough endoplasmic reticulum 1 PKM
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
catalase complex 1 CAT
autolysosome lumen 1 GAA
[Isoform M2]: Cytoplasm 1 PKM
[Isoform M1]: Cytoplasm 1 PKM
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Jiahui Yu, Jingchen Xie, Miao Sun, Suhui Xiong, Chunfang Xu, Zhimin Zhang, Minjie Li, Chun Li, Limei Lin. Plant-Derived Caffeic Acid and Its Derivatives: An Overview of Their NMR Data and Biosynthetic Pathways. Molecules (Basel, Switzerland). 2024 Apr; 29(7):. doi: 10.3390/molecules29071625. [PMID: 38611904]
  • Yang Gu, Yaru Jiang, Changfan Li, Jiang Zhu, Xueyao Lu, Jianyue Ge, Mengchen Hu, Jieying Deng, Jingbo Ma, Zhiliang Yang, Xiaoman Sun, Feng Xue, Guocheng Du, Peng Xu, He Huang. High titer production of gastrodin enabled by systematic refactoring of yeast genome and an antisense-transcriptional regulation toolkit. Metabolic engineering. 2024 Mar; 82(?):250-261. doi: 10.1016/j.ymben.2024.02.016. [PMID: 38428728]
  • Zimin Xiao, Jian Cai, Ting Chen, Yilin Wang, Yixin Chen, Yongyan Zhu, Chunmei Chen, Bin Yang, Xuefeng Zhou, Huaming Tao. Two New Sesquiterpenoids and a New Shikimic Acid Metabolite from Mangrove Sediment-Derived Fungus Roussoella sp. SCSIO 41427. Marine drugs. 2024 Feb; 22(3):. doi: 10.3390/md22030103. [PMID: 38535444]
  • Kateryna Kukil, Pia Lindberg. Metabolic engineering of Synechocystis sp. PCC 6803 for the improved production of phenylpropanoids. Microbial cell factories. 2024 Feb; 23(1):57. doi: 10.1186/s12934-024-02330-3. [PMID: 38369470]
  • Noah P Winters, Eric K Wafula, Benjamin J Knollenberg, Tuomas Hämälä, Prakash R Timilsena, Melanie Perryman, Dapeng Zhang, Lena L Sheaffer, Craig A Praul, Paula E Ralph, Sarah Prewitt, Mariela E Leandro-Muñoz, Diego A Delgadillo-Duran, Naomi S Altman, Peter Tiffin, Siela N Maximova, Claude W dePamphilis, James H Marden, Mark J Guiltinan. A combination of conserved and diverged responses underlies Theobroma cacao's defense response to Phytophthora palmivora. BMC biology. 2024 Feb; 22(1):38. doi: 10.1186/s12915-024-01831-2. [PMID: 38360697]
  • Vlastimil Novak, Peter F Andeer, Benjamin P Bowen, Yezhang Ding, Kateryna Zhalnina, Kirsten S Hofmockel, Connor Tomaka, Thomas V Harwood, Michelle C M van Winden, Amber N Golini, Suzanne M Kosina, Trent R Northen. Reproducible growth of Brachypodium in EcoFAB 2.0 reveals that nitrogen form and starvation modulate root exudation. Science advances. 2024 Jan; 10(1):eadg7888. doi: 10.1126/sciadv.adg7888. [PMID: 38170767]
  • Lars H Kruse, Frederick G Sunstrum, Daniela Garcia, Guillermo López Pérez, Sharon Jancsik, Joerg Bohlmann, Sandra Irmisch. Improved production of the antidiabetic metabolite montbretin A in Nicotiana benthamiana: discovery, characterization, and use of Crocosmia shikimate shunt genes. The Plant journal : for cell and molecular biology. 2023 Nov; ?(?):. doi: 10.1111/tpj.16528. [PMID: 37960967]
  • Xiao-Xia Zhu, Wan-Qiu Liu, Zhao-Xia Shi, Huang-Yao Zhu, Si-Qi Fan, Jie Zhang, Wen-Yuan Liu, Li-Jun Xu, Qing-Jia Ren, Feng Feng, Jian Xu. Meroterpenoids with divers' rings systems from Phyllosticta capitalensis and their anti-inflammatory activity. Phytochemistry. 2023 Nov; ?(?):113918. doi: 10.1016/j.phytochem.2023.113918. [PMID: 37952710]
  • Qiyuan Zou, Yuanyuan Huang, Wenyan Zhang, Chen Lu, Jingquan Yuan. A Comprehensive Review of the Pharmacology, Chemistry, Traditional Uses and Quality Control of Star Anise (Illicium verum Hook. F.): An Aromatic Medicinal Plant. Molecules (Basel, Switzerland). 2023 Nov; 28(21):. doi: 10.3390/molecules28217378. [PMID: 37959797]
  • Abigail Loren Tung Uy, Atsushi Yamamoto, Mami Matsuda, Toshihiro Arae, Tomohisa Hasunuma, Taku Demura, Misato Ohtani. The Carbon Flow Shifts from Primary to Secondary Metabolism during Xylem Vessel Cell Differentiation in Arabidopsis thaliana. Plant & cell physiology. 2023 Oct; ?(?):. doi: 10.1093/pcp/pcad130. [PMID: 37875012]
  • Inge Schwedt, Kerstin Schöne, Maike Eckert, Manon Pizzinato, Laura Winkler, Barbora Knotkova, Björn Richts, Jann-Louis Hau, Julia Steuber, Raul Mireles, Lianet Noda-Garcia, Günter Fritz, Carolin Mittelstädt, Robert Hertel, Fabian M Commichau. The low mutational flexibility of the EPSP synthase in Bacillus subtilis is due to a higher demand for shikimate pathway intermediates. Environmental microbiology. 2023 Oct; ?(?):. doi: 10.1111/1462-2920.16518. [PMID: 37822042]
  • Christodoulos Anagnostou, Stavros Beteinakis, Anastasia Papachristodoulou, Vasiliki K Pachi, Mariangela Dionysopoulou, Sofia Dimou, George Diallinas, Leandros A Skaltsounis, Maria Halabalaki. Phytochemical investigation of Pistacia lentiscus L. var. Chia leaves: A byproduct with antimicrobial potential. Fitoterapia. 2023 Aug; ?(?):105648. doi: 10.1016/j.fitote.2023.105648. [PMID: 37562489]
  • Zimin Wei, Yue Zhao, Li Zhao, Liqin Wang, Junqiu Wu. The contribution of microbial shikimic acid to humus formation during organic wastes composting: a review. World journal of microbiology & biotechnology. 2023 Jul; 39(9):240. doi: 10.1007/s11274-023-03674-5. [PMID: 37392253]
  • Xin Li, Kaibin Mo, Ge Tian, Jiaxin Zhou, Jiongzhou Gong, Li Li, Xianhui Huang. Shikimic Acid Regulates the NF-κB/MAPK Signaling Pathway and Gut Microbiota to Ameliorate DSS-Induced Ulcerative Colitis. Journal of agricultural and food chemistry. 2023 May; ?(?):. doi: 10.1021/acs.jafc.3c00283. [PMID: 37257042]
  • Anam Amin Shami, Muhammad Tayyab Akhtar, Muhammad Waseem Mumtaz, Hamid Mukhtar, Amna Tahir, Syed Shahzad-Ul-Hussan, Safee Ullah Chaudhary, Bushra Muneer, Hafsa Iftikhar, Marios Neophytou. NMR-Based Metabolomics: A New Paradigm to Unravel Defense-Related Metabolites in Insect-Resistant Cotton Variety through Different Multivariate Data Analysis Approaches. Molecules (Basel, Switzerland). 2023 Feb; 28(4):. doi: 10.3390/molecules28041763. [PMID: 36838756]
  • ZhiHao Dong, XiaoDong Liu, Anoop Kumar Srivastava, QiLing Tan, Wei Low, Xiang Yan, SongWei Wu, XueCheng Sun, ChengXiao Hu. Boron deficiency mediates plant-insect (Diaphorima citri) interaction by disturbing leaf volatile organic compounds and cell wall functions. Tree physiology. 2023 Jan; ?(?):. doi: 10.1093/treephys/tpac140. [PMID: 36611002]
  • Md Rafi Uz Zama Khan, Emiko Yanase, Vishal Trivedi. Extraction, phytochemical characterization and anti-cancer mechanism of Haritaki churna: An ayurvedic formulation. PloS one. 2023; 18(5):e0286274. doi: 10.1371/journal.pone.0286274. [PMID: 37256897]
  • Rodrigo Martinelli, Luiz Renato Rufino, Ana Caroline de Melo, Ricardo Alcántara-de la Cruz, Maria Fátima das Graças Fernandes da Silva, Jefferson Rangel da Silva, Rodrigo Marcelli Boaretto, Patricia Andrea Monquero, Dirceu Mattos, Fernando Alves de Azevedo. Glyphosate excessive use chronically disrupts the shikimate pathway and can affect photosynthesis and yield in citrus trees. Chemosphere. 2022 Dec; 308(Pt 3):136468. doi: 10.1016/j.chemosphere.2022.136468. [PMID: 36116622]
  • Amaranatha Reddy Vennapusa, Subham Agarwal, Hanumanth Rao Hm, Thiagarayaselvam Aarthy, K C Babitha, Hirekodathakallu V Thulasiram, Mahesh J Kulkarni, Kalpalatha Melmaiee, Chinta Sudhakar, M Udayakumar, Ramu S Vemanna. Stacking herbicide detoxification and resistant genes improves glyphosate tolerance and reduces phytotoxicity in tobacco (Nicotiana tabacum L.) and rice (Oryza sativa L.). Plant physiology and biochemistry : PPB. 2022 Oct; 189(?):126-138. doi: 10.1016/j.plaphy.2022.08.025. [PMID: 36084528]
  • Xuerui Lu, Shixi Shi, Chong Wu, Xueao Zheng, Chenkun Yang, Jie Luo, Shunping Yan. The shikimate pathway regulates programmed cell death. Journal of genetics and genomics = Yi chuan xue bao. 2022 10; 49(10):943-951. doi: 10.1016/j.jgg.2022.02.001. [PMID: 35167982]
  • Kazuya Koyama, Atsushi Kono, Yusuke Ban, Sharon Marie Bahena-Garrido, Tomoko Ohama, Kazuhiro Iwashita, Hisashi Fukuda, Nami Goto-Yamamoto. Genetic architecture of berry aroma compounds in a QTL (quantitative trait loci) mapping population of interspecific hybrid grapes (Vitis labruscana × Vitis vinifera). BMC plant biology. 2022 Sep; 22(1):458. doi: 10.1186/s12870-022-03842-z. [PMID: 36151514]
  • Shudh Kirti Dolma, S G Eswara Reddy. Characterization of Triadica sebifera (L.) Small Extracts, Antifeedant Activities of Extracts, Fractions, Seed Oil and Isolated Compounds against Plutella xylostella (L.) and Their Effect on Detoxification Enzymes. Molecules (Basel, Switzerland). 2022 Sep; 27(19):. doi: 10.3390/molecules27196239. [PMID: 36234776]
  • Zhong Zhang, Yang Yang, Qun Sun, Weicai Zeng, Yuqing Li. Inhibition of Biofilm Formation and Virulence Factors of Cariogenic Oral Pathogen Streptococcus mutans by Shikimic Acid. Microbiology spectrum. 2022 08; 10(4):e0119922. doi: 10.1128/spectrum.01199-22. [PMID: 35880891]
  • Di Dong, Zhuoxiong Yang, Yuan Ma, Shuwen Li, Mengdi Wang, Yinruizhi Li, Zhuocheng Liu, Chenyan Jia, Liebao Han, Yuehui Chao. Expression of a Hydroxycinnamoyl-CoA Shikimate/Quinate Hydroxycinnamoyl Transferase 4 Gene from Zoysia japonica (ZjHCT4) Causes Excessive Elongation and Lignin Composition Changes in Agrostis stolonifera. International journal of molecular sciences. 2022 Aug; 23(16):. doi: 10.3390/ijms23169500. [PMID: 36012757]
  • Sijia Wu, Wenjuan Chen, Sujuan Lu, Hailing Zhang, Lianghong Yin. Metabolic Engineering of Shikimic Acid Biosynthesis Pathway for the Production of Shikimic Acid and Its Branched Products in Microorganisms: Advances and Prospects. Molecules (Basel, Switzerland). 2022 Jul; 27(15):. doi: 10.3390/molecules27154779. [PMID: 35897952]
  • Yongbo Yu, Yang Yu, Na Cui, Lifeng Ma, Ran Tao, Zhangtong Ma, Xiangnan Meng, Haiyan Fan. Lignin biosynthesis regulated by CsCSE1 is required for Cucumis sativus defence to Podosphaera xanthii. Plant physiology and biochemistry : PPB. 2022 Jul; 186(?):88-98. doi: 10.1016/j.plaphy.2022.06.030. [PMID: 35830761]
  • Luis Orduña, Miaomiao Li, David Navarro-Payá, Chen Zhang, Antonio Santiago, Pablo Romero, Živa Ramšak, Gabriele Magon, Janine Höll, Patrick Merz, Kristina Gruden, Alessandro Vannozzi, Dario Cantu, Jochen Bogs, Darren C J Wong, Shao-Shan Carol Huang, José Tomás Matus. Direct regulation of shikimate, early phenylpropanoid, and stilbenoid pathways by Subgroup 2 R2R3-MYBs in grapevine. The Plant journal : for cell and molecular biology. 2022 04; 110(2):529-547. doi: 10.1111/tpj.15686. [PMID: 35092714]
  • Kaoutar Benrahou, Hanae Naceiri Mrabti, Saad Fettach, Mohamed Reda Kachmar, Mostafa Kouach, Jean-François Goossens, Latifa Doudach, Shafi Mahmud, Mohammed Merae Alshahrani, Ahmed Abdullah Al Awadh, Abdelhakim Bouyahya, My El Abbes Faouzi. Mineral and Phenolic Composition of Erodium guttatum Extracts and Investigation of Their Antioxidant Properties in Diabetic Mice. Oxidative medicine and cellular longevity. 2022; 2022(?):4229981. doi: 10.1155/2022/4229981. [PMID: 36193070]
  • Han-Na Lee, Seung-Yeul Seo, Hey-Jin Kim, Ji-Hoon Park, Eunhwi Park, Si-Sun Choi, Sang Joung Lee, Eung-Soo Kim. Artificial cell factory design for shikimate production in Escherichia coli. Journal of industrial microbiology & biotechnology. 2021 Dec; 48(9-10):. doi: 10.1093/jimb/kuab043. [PMID: 34227672]
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