Rhein (BioDeep_00000002810)

 

Secondary id: BioDeep_00000398588

human metabolite PANOMIX_OTCML-2023 Volatile Flavor Compounds


代谢物信息卡片


4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid

化学式: C15H8O6 (284.0320868)
中文名称: 大黄酸
谱图信息: 最多检出来源 Viridiplantae(plant) 2.25%

Reviewed

Last reviewed on 2024-10-24.

Cite this Page

Rhein. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/rhein (retrieved 2024-11-25) (BioDeep RN: BioDeep_00000002810). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C12C(O)=CC(C(=O)O)=CC=1C(=O)C1=C(C(O)=CC=C1)C2=O
InChI: InChI=1S/C15H8O6/c16-9-3-1-2-7-11(9)14(19)12-8(13(7)18)4-6(15(20)21)5-10(12)17/h1-5,16-17H,(H,20,21)

描述信息

Rhein appears as yellow needles (from methanol) or yellow-brown powder. (NTP, 1992)
Rhein is a dihydroxyanthraquinone.
Rhein is an anthraquinone metabolite of rheinanthrone and senna glycoside is present in many medicinal plants including Rheum palmatum, Cassia tora, Polygonum multiflorum, and Aloe barbadensis. It is known to have hepatoprotective, nephroprotective, anti-cancer, anti-inflammatory, and several other protective effects.
Rhein is a natural product found in Cassia renigera, Rheum compactum, and other organisms with data available.
Present in Rheum palmatum (Chinese rhubarb). Rhein is found in dock, green vegetables, and garden rhubarb.
Rhein is found in dock. Rhein is present in Rheum palmatum (Chinese rhubarb
D004791 - Enzyme Inhibitors
KEIO_ID R037

同义名列表

58 个代谢物同义名

9,10-Dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylic acid, 9CI; 4,5-bis(oxidanyl)-9,10-bis(oxidanylidene)anthracene-2-carboxylic acid; 2-Anthracenecarboxylic acid, 9,10-dihydro-4,5-dihydroxy-9,10-dioxo-; 4,5-Dihydroxy-9,10-dioxo-9,10-dihydro-2-anthracenecarboxylic acid #; 9,10-Dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracene carboxylic acid; 9,10-Dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylic acid; 4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid; 9,10-Dihydro-4,5-dihydroxy-9,10-dioxoanthracene-2-carboxylic acid; 4,5-Dihydroxy-9,10-dioxo-9,10-dihydro-2-anthracenecarboxylic acid; 2-Anthracenecarboxylic acid,10-dihydro-4,5-dihydroxy-9,10-dioxo-; 4,5-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylicacid; 2-Anthroic acid, 9,10-dihydro-4,5-dihydroxy-9,10-dioxo-; 4,5-dihydroxy-9,10-diketo-anthracene-2-carboxylic acid; 9,10-Dihydro-4,5-dihydroxy-9,10-dioxo-2-anthroic acid; 4,5-dihydroxy-9,10-dioxo-anthracene-2-carboxylic acid; 4,5-dihydroxy-9,10-dioxoanthracene-2-carboxylic acid; 4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylic acid; 2-Anthroic acid,10-dihydro-4,5-dihydroxy-9,10-dioxo-; 4,5-dihydroxy-9,10-dioxoanthracene-2-carboxylicacid; Rhein (1,8-dihydroxy-3-carboxyl anthraquinone); 2-Anthraquinonecarboxylic acid, 4,5-dihydroxy-; 4, 5-Dihydroxyanthraquinone-2-carboxylic acid; 4-10-00-04088 (Beilstein Handbook Reference); 4,5-Dihydroxy-2-anthraquinonecarboxylic acid; 4,5-dihydroxyanthraquinone-2-carboxylic acid; 1,8-Dihydroxyanthraquinone-3-carboxylic acid; 1,8-dihydroxy-3-carboxyl-9,10-anthraquinone; DIHYDROXY-3-CARBOXYLANTHRAQUINONE, 1,8-; 1,8-DIHYDROXY-3-CARBOXYL ANTHRAQUINONE; 1,8-Dihydroxy-3-carboxyanthraquinone; 4,5-DiOH-anthraquinone-2-COOH; Chrysazin-3-carboxylic acid; Rhein, analytical standard; Rhein, technical grade; Rhein; Rhubarb Yellow; dipropionyl rhein; Rhein(Monorhein); UNII-YM64C2P6UX; Rhubarb Yellow; MEGxp0_001866; Parietic acid; RHEIN [INCI]; Tox21_201098; ACon1_000217; Rheinic acid; Cassic acid; RHEIN [MI]; YM64C2P6UX; Rheic acid; Monorhein; Rhein,(S); C15H8O6; Rhein; Rheic; 4ie7; RHN; Rhein; Rhein



数据库引用编号

31 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

45 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Huang-Fei Jin, Qian-Xue Shen, Ying Shi, Fang-Ming Liu, Bin Wang, Jun Cao, Li-Hong Ye. Magnetic-stirring-enhanced mechanical amorphous dispersion extraction for the hydrophobic phytochemical constituents using an aqueous solution from a medicinal plant. Journal of pharmaceutical and biomedical analysis. 2024 Aug; 245(?):116191. doi: 10.1016/j.jpba.2024.116191. [PMID: 38728950]
  • Shujun Xu, Shuang Zheng, Ninghui Ma, Hongyan Zhang, Jingbin Shi, Jingyi Huang, Ninghchao Luo, Menglin Wang, Yang Xiong. Rhein potentiates doxorubicin in treating triple negative breast cancer by inhibiting cancer-associated fibroblasts. Biochemical pharmacology. 2024 May; 223(?):116139. doi: 10.1016/j.bcp.2024.116139. [PMID: 38499109]
  • Tianyi Zhao, Shiyi Lun, Maoying Yan, JongPil Park, Shumin Wang, Changbao Chen. 6,7-Dimethoxycoumarin, Gardenoside and Rhein combination improves non-alcoholic fatty liver disease in rats. Journal of ethnopharmacology. 2024 Mar; 322(?):117646. doi: 10.1016/j.jep.2023.117646. [PMID: 38135236]
  • Bi Wang, Jingjing Yang, Xingzeng Zhao, Xu Feng, Shu Xu, Pirui Li, Linwei Li, Yu Chen. Antifungal activity of the botanical compound rhein against Phytophthora capsici and the underlying mechanisms. Pest management science. 2024 Mar; 80(3):1228-1239. doi: 10.1002/ps.7852. [PMID: 37897133]
  • Lifang Wang, Haijao Wang, Jingjing Niu, Honggang Chen, Meng Wang, Zhigang Yang, Shaohua Wang, Xiuxia Sun, Yanbin Shi. Cholesterol-lowering effects of rhubarb free anthraquinones and their mechanism of action. European journal of pharmacology. 2024 Jan; ?(?):176348. doi: 10.1016/j.ejphar.2024.176348. [PMID: 38286356]
  • Qiang Huang, Meiling Fan, Fenglan Ji, Yuqi Wang, Hongyue Ding, Jie Xu, Xin Wang, Bo Liu, Bei Wang, Xinmiao Yu, Zhidong Qiu, Fan Yao. The safety evaluation of Shenze Shugan capsule and mechanism of apoptosis induced by five potentially nephrotoxic components. Journal of ethnopharmacology. 2024 Jan; 324(?):117777. doi: 10.1016/j.jep.2024.117777. [PMID: 38219879]
  • Xu Zhang, Mingyang Xue, Lei Liu, Huan Wang, Tianxiu Qiu, Yan Zhou, Lipeng Shan, Zixuan Wang, Guanglu Liu, Yang Hu, Jiong Chen. Rhein: A potent immunomodulator empowering largemouth bass against MSRV infection. Fish & shellfish immunology. 2024 Jan; 144(?):109284. doi: 10.1016/j.fsi.2023.109284. [PMID: 38092092]
  • Jiao Wang, Jin Zhang, Zeyu Guo, Hui Hua, Hongying Zhang, Yongliang Liu, Yangfu Jiang. Targeting HSP70 chaperones by rhein sensitizes liver cancer to artemisinin derivatives. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jan; 122(?):155156. doi: 10.1016/j.phymed.2023.155156. [PMID: 37897861]
  • Fang Zhang, Rui Wu, Yanfang Liu, Shu Dai, Xinyan Xue, Xiaohong Gong, Yunxia Li. Comparative Pharmacokinetic Study of Rhubarb Anthraquinones in Normal and Nonalcoholic Fatty Liver Disease Rats. European journal of drug metabolism and pharmacokinetics. 2024 Jan; 49(1):111-121. doi: 10.1007/s13318-023-00875-z. [PMID: 38112917]
  • Yanli Wang, Siwei Zhong, Ke Yang, Ruifeng Luo, Linxin Dai, Wenzhen Zhong, Yan Ye, Chaomei Fu, Dasheng Lin, Nan Li, Jianping Chen, Chuan Zheng, Shu Fu, Fei Gao. β-1,3-d-glucan particles-based "nest" protected co-loaded Rhein and Emodin regulates microbiota and intestinal immunity for ulcerative colitis treatment. International journal of biological macromolecules. 2023 Dec; 260(Pt 2):128818. doi: 10.1016/j.ijbiomac.2023.128818. [PMID: 38103669]
  • Wessam M El-Refaie, Mostafa S Ghazy, Fady A Ateyya, Eman Sheta, Mohanad Y Shafek, Mahmoud S Ibrahim, Mahmoud Ma Ismail, Mennatallah A Gowayed. Rhein methotrexate-decorated solid lipid nanoparticles altering adjuvant arthritis progression through endoplasmic reticulum stress-mediated apoptosis. Inflammopharmacology. 2023 Dec; 31(6):3127-3142. doi: 10.1007/s10787-023-01295-w. [PMID: 37526838]
  • Huijuan Lv, Jingjing Niu, Wenhao Pan, Yudong Wang, Lifang Wang, Meng Wang, Yali Shi, Guifang Zhang, Bandar Al Hamyari, Shaohua Wang, Xuefeng Li, Yanbin Shi. Stool-softening effect and action mechanism of free anthraquinones extracted from Rheum palmatum L. on water deficit-induced constipation in rats. Journal of ethnopharmacology. 2023 Oct; 319(Pt 3):117336. doi: 10.1016/j.jep.2023.117336. [PMID: 37907143]
  • Zebu Song, Yang Chen, Hao Chang, Yanchen Guo, Qi Gao, Zhi Wei, Lang Gong, Guihong Zhang, ZeZhong Zheng. Rhein suppresses African swine fever virus replication in vitro via activating the caspase-dependent mitochondrial apoptosis pathway. Virus research. 2023 Oct; ?(?):199238. doi: 10.1016/j.virusres.2023.199238. [PMID: 37827302]
  • Xi Mao, Ding-Qiao Xu, Shi-Jun Yue, Rui-Jia Fu, Sai Zhang, Yu-Ping Tang. Potential Medicinal Value of Rhein for Diabetic Kidney Disease. Chinese journal of integrative medicine. 2023 Oct; 29(10):951-960. doi: 10.1007/s11655-022-3591-y. [PMID: 36607584]
  • Hua Liu, Tian-Ai Zhang, Wen-Yue Zhang, Si-Rui Huang, Yue Hu, Jia Sun. Rhein attenuates cerebral ischemia-reperfusion injury via inhibition of ferroptosis through NRF2/SLC7A11/GPX4 pathway. Experimental neurology. 2023 Sep; ?(?):114541. doi: 10.1016/j.expneurol.2023.114541. [PMID: 37714424]
  • Pablo Zambrano, Malgorzata Jemiola-Rzeminska, Diego Muñoz-Torrero, Mario Suwalsky, Kazimierz Strzalka. A rhein-huprine hybrid protects erythrocyte membrane integrity against Alzheimer's disease related Aβ(1-42) peptide. Biophysical chemistry. 2023 09; 300(?):107061. doi: 10.1016/j.bpc.2023.107061. [PMID: 37307659]
  • Yahui Hu, Shasha He, Xiaolong Xu, Xuran Cui, Yiming Wei, Chunxia Zhao, Haoran Ye, Jingxia Zhao, Qingquan Liu. Shenhuangdan decoction alleviates sepsis-induced lung injury through inhibition of GSDMD-mediated pyroptosis. Journal of ethnopharmacology. 2023 Aug; 318(Pt B):117047. doi: 10.1016/j.jep.2023.117047. [PMID: 37586442]
  • ShengHao Chen, YanLan Liang, YuanYuan Li, Yue Sun, Yang He. Determination of rhein and physcion in rhubarb by microchip capillary electrophoresis in mixed hydro-organic solvent combined with laser-induced fluorescence detection. Journal of separation science. 2023 Jul; ?(?):e2300192. doi: 10.1002/jssc.202300192. [PMID: 37507831]
  • Fei Cao, Jie Xiang, Yaodong Wang, Xijie Chen, Xirong Lu, Xingmeng Xu, Lin Chen, Yinghong Fan, Chenchen Yuan, Xiaowu Dong, Qingtian Zhu, Chenxia Han, Guotao Lu, Qing Xia, Weiwei Chen. Chaiqin chengqi decoction alleviates acute pancreatitis by targeting gasdermin D-mediated pyroptosis. Journal of ethnopharmacology. 2023 Jul; 318(Pt A):116920. doi: 10.1016/j.jep.2023.116920. [PMID: 37480969]
  • Jianhang Bao, Wenshuo Gao, Wei Zhang, Dong Wang, Hao Pan. Fibrin glue delivery system containing rhein ameliorates intervertebral disc degeneration by anti-inflammatory efficacy. Journal of orthopaedic surgery and research. 2023 Jul; 18(1):485. doi: 10.1186/s13018-023-03961-9. [PMID: 37415165]
  • Yudan Mei, Xiaoyu Tong, Yumei Hu, Wenjun Liu, Jiajia Wang, Kaihong Lv, Xu Li, Liang Cao, Zhenzhong Wang, Wei Xiao, Xia Gao. Comparative pharmacokinetics of six bioactive components of Shen-Wu-Yi-Shen tablets in normal and chronic renal failure rats based on UPLC-TSQ-MS/MS. Journal of ethnopharmacology. 2023 Jun; 317(?):116818. doi: 10.1016/j.jep.2023.116818. [PMID: 37348793]
  • Xinqiu Li, Zixiang Lin, Penglong Wang, Chaoyu Zhou, Jiawei Xu, Jiahao Lin, Degui Lin, Di Zhang. Tetramethylpyrazine-Rhein Derivative inhibits the migration of canine inflammatory mammary carcinoma cells by mitochondrial damage-mediated apoptosis and cadherins downregulation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Jun; 162(?):114731. doi: 10.1016/j.biopha.2023.114731. [PMID: 37086510]
  • H Wang, M Li, S Li, J Shi, L Huang, S Cheng, C Zou, H Yan. [Spectrum-effect relationship of total anthraquinone extract of Cassia seeds against fluorouracil-induced liver injury in mice]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. 2023 May; 43(5):825-831. doi: 10.12122/j.issn.1673-4254.2023.05.19. [PMID: 37313825]
  • Haibo Zhang, Lei Ma, Eungyung Kim, Junkoo Yi, Hai Huang, Hyeonjin Kim, Muhammad Atif Raza, Sijun Park, Soyoung Jang, Kirim Kim, Sung-Hyun Kim, Youngkyun Lee, Eunkyong Kim, Zae Young Ryoo, Myoung Ok Kim. Rhein Induces Oral Cancer Cell Apoptosis and ROS via Suppresse AKT/mTOR Signaling Pathway In Vitro and In Vivo. International journal of molecular sciences. 2023 May; 24(10):. doi: 10.3390/ijms24108507. [PMID: 37239855]
  • Song Liu, Lei Shu, Jiayao Yang, Yi Liu, Shu Zhang, Nian Wang, Zhaohong Shi. Rhein Exhibits Anti-Inflammatory Effects in Chronic Atrophic Gastritis via Nrf2 and MAPK Signaling. The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology. 2023 05; 34(5):525-532. doi: 10.5152/tjg.2023.22251. [PMID: 36789982]
  • Si Li, Xi Wu, Yue Ma, Hua Zhang, Wen Chen. Prediction and verification of the active ingredients and potential targets of Erhuang Quzhi Granules on non-alcoholic fatty liver disease based on network pharmacology. Journal of ethnopharmacology. 2023 Apr; ?(?):116435. doi: 10.1016/j.jep.2023.116435. [PMID: 37023836]
  • Fan Wu, Ting Zhao, Yu Zhang, Yan Wang, Guoxin Liao, Baojing Zhang, Chao Wang, Xiangge Tian, Lei Feng, Bangjiang Fang, Xiaokui Huo, Xiaochi Ma. Beneficial herb-drug interaction of rhein in Jinhongtang and Imipenem/Cilastatin mediated by organic anion transporters. Journal of ethnopharmacology. 2023 Apr; ?(?):116449. doi: 10.1016/j.jep.2023.116449. [PMID: 37023835]
  • Fan Wu, Yan Wang, Quanxi Mei, Qinhua Chen, Chengpeng Sun, Xia Lv, Lei Feng, Chao Wang, Yanyan Zhang, Bangjiang Fang, Xiaokui Huo, Xiangge Tian, Xiaochi Ma. UGTs-mediated metabolic interactions contribute to enhanced anti-inflammation activity of Jinhongtang. Journal of ethnopharmacology. 2023 Mar; 304(?):116016. doi: 10.1016/j.jep.2022.116016. [PMID: 36535328]
  • Dongpeng Wang, Jufeng Duan, Xiao-Jing Chen, Kaiqi Liu, Yingying Guo, Run Shi, Sha Li, Ming Liu, Lijun Zhao, Bei Li, Hongtao Liu, Minglun Li, Yibin Feng, Hongliang Li, Xuanbin Wang. Pharmacokinetic characteristics of emodin in polygoni Multiflori Radix Praeparata. Journal of ethnopharmacology. 2023 Mar; 303(?):115945. doi: 10.1016/j.jep.2022.115945. [PMID: 36435407]
  • Wenting Su, Congyan Liu, Xi Jiang, Yanli Lv, Qin Chen, Jiachen Shi, Huangqin Zhang, Qiuling Ma, Chang Ge, Fei Kong, Xiaoqi Li, Yuping Liu, Yan Chen, Ding Qu. An intravitreal-injectable hydrogel depot doped borneol-decorated dual-drug-coloaded microemulsions for long-lasting retina delivery and synergistic therapy of wAMD. Journal of nanobiotechnology. 2023 Mar; 21(1):71. doi: 10.1186/s12951-023-01829-y. [PMID: 36859261]
  • Shunshun Chen, Meimei Wang, Linhua Yu, Jinchao Shi, Yong Zhang, Yao Tian, Li Li, Xiang Zhu, Junkai Li. Rhein-Amino Acid Ester Conjugates as Potential Antifungal Agents: Synthesis and Biological Evaluation. Molecules (Basel, Switzerland). 2023 Feb; 28(5):. doi: 10.3390/molecules28052074. [PMID: 36903319]
  • Lingling Wang, Guoying Zhou, Shuo Zhao, Yang Yang. Soluble protein content, bioactive compounds and the antioxidant activity in seeds of ten Rheum tanguticum lines from Qinghai-Tibet Plateau. Chemistry & biodiversity. 2023 Feb; ?(?):e202200901. doi: 10.1002/cbdv.202200901. [PMID: 36788177]
  • Chuankui Fu, Yiheng Zhang, Wen Jie Xi, Kejia Xu, Fansheng Meng, Tianle Ma, Weidong Li, Li Wu, Zhipeng Chen. Dahuang Zhechong pill attenuates hepatic sinusoidal capillarization in liver cirrhosis and hepatocellular carcinoma rat model via the MK/integrin signaling pathway. Journal of ethnopharmacology. 2023 Jan; 308(?):116191. doi: 10.1016/j.jep.2023.116191. [PMID: 36731809]
  • Qili Wang, Shunping Han, Yongqin Zhu, Guowei Wang, Danfei Chen. Poly-γ-glutamic acid coating polymeric nanoparticles enhance renal drug distribution and cellular uptake for diabetic nephropathy therapy. Journal of drug targeting. 2023 01; 31(1):89-99. doi: 10.1080/1061186x.2022.2106488. [PMID: 35880399]
  • Jijia Sun, Qinghua Ni, Fengyan Jiang, Baocheng Liu, Jianying Wang, Lei Zhang, Jihan Huang. Discovery and Validation of Traditional Chinese and Western Medicine Combination Antirheumatoid Arthritis Drugs Based on Machine Learning (Random Forest Model). BioMed research international. 2023; 2023(?):6086388. doi: 10.1155/2023/6086388. [PMID: 36845640]
  • Heba M K Ebada, Maha M A Nasra, Rasha A Nassra, Ossama Y Abdallah. Chondroitin sulfate-functionalized lipid nanoreservoirs: a novel cartilage-targeting approach for intra-articular delivery of cassic acid for osteoarthritis treatment. Drug delivery. 2022 Dec; 29(1):652-663. doi: 10.1080/10717544.2022.2041130. [PMID: 35188017]
  • Shanshan Qi, Ruifeng Luo, Xiaoqin Han, Wenbiao Nie, Naijing Ye, Chaomei Fu, Fei Gao. pH/ROS Dual-Sensitive Natural Polysaccharide Nanoparticles Enhance "One Stone Four Birds" Effect of Rhein on Ulcerative Colitis. ACS applied materials & interfaces. 2022 Nov; 14(45):50692-50709. doi: 10.1021/acsami.2c17827. [PMID: 36326017]
  • Ya Zhao, Jinqiu Wang, Lijuan Liu, Yayun Wu, Qiaohong Hu, Ruizhi Zhao. Vinegar-baked Radix Bupleuri enhances the liver-targeting effect of rhein on liver injury rats by regulating transporters. The Journal of pharmacy and pharmacology. 2022 Nov; 74(11):1588-1597. doi: 10.1093/jpp/rgac062. [PMID: 36181768]
  • Yanna Zhu, Shilei Yang, Linlin Lv, Xiaohan Zhai, Guoyu Wu, Xiaolin Qi, Deshi Dong, Xufeng Tao. Research Progress on the Positive and Negative Regulatory Effects of Rhein on the Kidney: A Review of Its Molecular Targets. Molecules (Basel, Switzerland). 2022 Oct; 27(19):. doi: 10.3390/molecules27196572. [PMID: 36235108]
  • Ning Xu, Yuanran Chen, Dongjie Guo, Yu Deng, Wanjun Guo, Xin Liu, Yi Wang, Hanzhi Lu, Aijun Liu, Jianyong Zhu, Fulun Li. Rhein promotes the proliferation of keratinocytes by targeting oestrogen receptors for skin ulcer treatment. BMC complementary medicine and therapies. 2022 Aug; 22(1):209. doi: 10.1186/s12906-022-03691-1. [PMID: 35932049]
  • Veronica Folliero, Federica Dell'Annunziata, Emanuela Roscetto, Alessandra Amato, Roberta Gasparro, Carla Zannella, Vincenzo Casolaro, Anna De Filippis, Maria Rosaria Catania, Gianluigi Franci, Massimiliano Galdiero. Rhein: A novel antibacterial compound against Streptococcus mutans infection. Microbiological research. 2022 Aug; 261(?):127062. doi: 10.1016/j.micres.2022.127062. [PMID: 35597077]
  • Fan Wu, Baojing Zhang, Yu Zhang, Ting Zhao, Yan Wang, Xiangge Tian, Chengpeng Sun, Bangjiang Fang, Xiaokui Huo, Xiaochi Ma. Simultaneous Determination of Ten Active Components From Jinhongtang Granule in Rat Plasma by LC-MS/MS and its Application to a Comparative Pharmacokinetic Study in Normal and Sepsis Rats In Vivo and In Vitro. Journal of chromatographic science. 2022 Aug; ?(?):. doi: 10.1093/chromsci/bmac043. [PMID: 35913259]
  • Fei Gao, Hui-Yun Zhong, Ke-Xi Chen, Ling-Ling Dong, Mei-Si Lin, Hong-Ling DU. [Mechanism of combined treatment of rhein and emodin in Rhubarb for ulcerative colitis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Aug; 47(15):4148-4155. doi: 10.19540/j.cnki.cjcmm.20220509.702. [PMID: 36046905]
  • Qiming Xiao, Xixi Yu, Xinwei Yu, Shundi Liu, Jianping Jiang, Yu Cheng, Hao Lin, Yuzhen Wang, Xiaoshan Zhang, Xiaoxia Ye, Zheng Xiang. An integrated network pharmacology and cell metabolomics approach to reveal the role of rhein, a novel PPARα agonist, against renal fibrosis by activating the PPARα-CPT1A axis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Jul; 102(?):154147. doi: 10.1016/j.phymed.2022.154147. [PMID: 35567992]
  • Gang Min Li, Jun Ren Chen, Hui Qiong Zhang, Chen Sun, Guan Ru Chen, Qiu Yun Xiong, Xiao Yu Cao, Lei Yu, Zi Wei Lin, Jun Yuan Qin, Liu Jun Wu, Jing Li, Lin Pu, Fu Peng, Xiao Fang Xie, Cheng Peng. Rhein activated Fas-induced apoptosis pathway causing cardiotoxicity in vitro and in vivo. Toxicology letters. 2022 Jun; 363(?):67-76. doi: 10.1016/j.toxlet.2022.04.006. [PMID: 35589017]
  • Dong Yang, Wan-Yi Huang, Yan-Qiao Li, Shi-Yu Chen, Si-Yu Su, Yue Gao, Xian-Li Meng, Ping Wang. Acute and subchronic toxicity studies of rhein in immature and d-galactose-induced aged mice and its potential hepatotoxicity mechanisms. Drug and chemical toxicology. 2022 May; 45(3):1119-1130. doi: 10.1080/01480545.2020.1809670. [PMID: 32842782]
  • Lingling Dong, Hongling Du, Minyue Zhang, Haiting Xu, Xiulan Pu, Qiyan Chen, Ruifeng Luo, Yichen Hu, Yitao Wang, He Tu, Jinming Zhang, Fei Gao. Anti-inflammatory effect of Rhein on ulcerative colitis via inhibiting PI3K/Akt/mTOR signaling pathway and regulating gut microbiota. Phytotherapy research : PTR. 2022 May; 36(5):2081-2094. doi: 10.1002/ptr.7429. [PMID: 35229916]
  • Xianrui Song, Zesen Du, Zhenqi Yao, Xiaoyan Tang, Mian Zhang. Rhein Improves Renal Fibrosis by Restoring Cpt1a-Mediated Fatty Acid Oxidation through SirT1/STAT3/twist1 Pathway. Molecules (Basel, Switzerland). 2022 Apr; 27(7):. doi: 10.3390/molecules27072344. [PMID: 35408745]
  • Feng Junfang, Chen Ou, Wang Yibiao. Anti-inflammatory mechanism of rhein in treating asthma based on network pharmacology. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2022 04; 42(2):296-303. doi: 10.19852/j.cnki.jtcm.20220225.003. [PMID: 35473352]
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