Fumitremorgin C (BioDeep_00000002789)

 

Secondary id: BioDeep_00000614768

human metabolite natural product


代谢物信息卡片


(1S,12S,15S)-7-methoxy-12-(2-methylprop-1-en-1-yl)-10,13,19-triazapentacyclo[11.7.0.0³,¹¹.0⁴,⁹.0¹⁵,¹⁹]icosa-3(11),4,6,8-tetraene-14,20-dione

化学式: C22H25N3O3 (379.189582)
中文名称: 烟曲霉毒素C
谱图信息: 最多检出来源 Homo sapiens(natural_products) 1.99%

Reviewed

Last reviewed on 2024-08-26.

Cite this Page

Fumitremorgin C. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/fumitremorgin_c (retrieved 2024-09-17) (BioDeep RN: BioDeep_00000002789). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CC(=CC1C2=C(CC3N1C(=O)C4CCCN4C3=O)C5=C(N2)C=C(C=C5)OC)C
InChI: InChI=1S/C22H25N3O3/c1-12(2)9-18-20-15(14-7-6-13(28-3)10-16(14)23-20)11-19-21(26)24-8-4-5-17(24)22(27)25(18)19/h6-7,9-10,17-19,23H,4-5,8,11H2,1-3H3

描述信息

Fumitremorgin C is produced by Aspergillus fumigatus and Neosartorya fischeri.
Production by Aspergillus fumigatus and Neosartorya fischeri

Fumitremorgin C. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=118974-02-0 (retrieved 2024-08-26) (CAS RN: 118974-02-0). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

同义名列表

11 个代谢物同义名

(1S,12S,15S)-7-methoxy-12-(2-methylprop-1-en-1-yl)-10,13,19-triazapentacyclo[11.7.0.0³,¹¹.0⁴,⁹.0¹⁵,¹⁹]icosa-3(11),4,6,8-tetraene-14,20-dione; Tryproquivaline m (2s-(2alpha,9alpha(4S*(s*)),9abeta))-isomer; Tryproquivaline D (2s-(2alpha,9alpha(4R*(s*)),9abeta))-isomer; Tryproquivaline m (2s-(2alpha,9alpha(4R*(s*)),9abeta))-isomer; Tryproquivaline N (2s-(2alpha,9alpha(r*),9abeta))-isomer; Tryproquivaline L (9r-(9alpha(s*),9abeta))-isomer; Tryproquivaline L (9r-(9alpha(r*),9abeta))-isomer; 12alpha-Fumitremorgin C; Fumitremorgin C; Tryptoquivaline; SM-Q



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(2)

PlantCyc(0)

代谢反应

3 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(3)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

13 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

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  • Scott M Jackson, Ioannis Manolaridis, Julia Kowal, Melanie Zechner, Nicholas M I Taylor, Manuel Bause, Stefanie Bauer, Ruben Bartholomaeus, Guenther Bernhardt, Burkhard Koenig, Armin Buschauer, Henning Stahlberg, Karl-Heinz Altmann, Kaspar P Locher. Structural basis of small-molecule inhibition of human multidrug transporter ABCG2. Nature structural & molecular biology. 2018 04; 25(4):333-340. doi: 10.1038/s41594-018-0049-1. [PMID: 29610494]
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  • T S Garimella, D D Ross, J L Eiseman, J T Mondick, E Joseph, T Nakanishi, S E Bates, K S Bauer. Plasma pharmacokinetics and tissue distribution of the breast cancer resistance protein (BCRP/ABCG2) inhibitor fumitremorgin C in SCID mice bearing T8 tumors. Cancer chemotherapy and pharmacology. 2005 Feb; 55(2):101-9. doi: 10.1007/s00280-004-0866-2. [PMID: 15580504]
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  • Zhe-Sheng Chen, Robert W Robey, Martin G Belinsky, Irina Shchaveleva, Xiao-Qin Ren, Yoshikazu Sugimoto, Douglas D Ross, Susan E Bates, Gary D Kruh. Transport of methotrexate, methotrexate polyglutamates, and 17beta-estradiol 17-(beta-D-glucuronide) by ABCG2: effects of acquired mutations at R482 on methotrexate transport. Cancer research. 2003 Jul; 63(14):4048-54. doi: . [PMID: 12874005]