Tangeretin (BioDeep_00000270753)

Main id: BioDeep_00000230075

 

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


4H-1-Benzopyran-4-one, 5,6,7,8-tetra-methoxy-2-(4-methoxyphenyl)-

化学式: C20H20O7 (372.1209)
中文名称: 桔皮素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: c1(c(c(c2c(c1OC)oc(cc2=O)c1ccc(cc1)OC)OC)OC)OC
InChI: InChI=1S/C20H20O7/c1-22-12-8-6-11(7-9-12)14-10-13(21)15-16(23-2)18(24-3)20(26-5)19(25-4)17(15)27-14/h6-10H,1-5H3

描述信息

Tangeretin (Tangeritin), a flavonoid from citrus fruit peels, has been proven to play an important role in anti-inflammatory responses and neuroprotective effects in several disease models, and is a Notch-1 inhibitor.
Tangeretin (Tangeritin), a flavonoid from citrus fruit peels, has been proven to play an important role in anti-inflammatory responses and neuroprotective effects in several disease models, and is a Notch-1 inhibitor.

同义名列表

46 个代谢物同义名

4H-1-Benzopyran-4-one, 5,6,7,8-tetra-methoxy-2-(4-methoxyphenyl)-; 4H-1-Benzopyran-4-one, 5,6,7,8-tetramethoxy-2-(p-methoxyphenyl)-; 4H-1-Benzopyran-4-one, 5,6,7,8-tetramethoxy-2-(4-methoxyphenyl)-; 4H-1-Benzopyran-4-one, 2-(4-methoxyphenyl)-5,6,7,8-tetramethoxy-; 2-(4-Methoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one; 5,6,7,8-tetramethoxy-2-(4-methoxyphenyl)-4H-chromen-4-one; 5,6,7,8-Tetramethoxy-2-(4-methoxyphenyl)-4-benzopyrone; 5,6,7,8-tetramethoxy-2-(4-methoxyphenyl)-4-chromenone; 5,6,7,8-tetramethoxy-2-(4-methoxyphenyl)chromen-4-one; 5,6,7,8-tetramethoxy-2-(4-methoxyphenyl)chromone; 5-18-05-00491 (Beilstein Handbook Reference); Flavone, 4,5,6,7,8-pentamethoxy- (7CI,8CI); Flavone, 4,5,6,7,8-pentamethoxy-; Flavone, 5,6,7,8,4-pentamethoxy; 4,5,6,7,8-pentamethoxyflavone; 5,6,7,8,4-Pentamethoxyflavone; SDCCGMLS-0066766.P001; Pentamethoxyflavone; EINECS 207-570-1; Tangeretin (6CI); Spectrum2_001698; Spectrum4_001019; Spectrum3_000920; NCGC00095850-01; SPECTRUM1505269; MEGxp0_001011; KBioGR_001517; KBio3_001900; ACon1_001263; SPBio_001656; NCI60_004330; AIDS-035256; BRN 0351695; CHEBI:9400; Tangeretin; Ponkanetin; tangeritin; AIDS035256; NSC618905; AI3-23869; NSC 53909; NSC53909; 481-53-8; C10190; 5,6,7,8-Tetramethoxy-2- (4-methoxyphenyl) -4H-1-benzopyran-4-one; Tangeretin



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

192 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 13 ABCB1, AKT1, BCL2, CASP3, EGFR, MAPK14, MTOR, NFE2L2, PIK3CA, PIK3R6, PTGS2, TP53, VEGFA
Peripheral membrane protein 4 CYP1B1, MTOR, PIK3R6, PTGS2
Endosome membrane 2 EGFR, NOTCH1
Endoplasmic reticulum membrane 7 BCL2, CYP1B1, EGFR, HMOX1, MTOR, NOTCH1, PTGS2
Nucleus 11 AKT1, BCL2, CASP3, EGFR, HMOX1, MAPK14, MTOR, NFE2L2, NOTCH1, TP53, VEGFA
cytosol 11 AKT1, BCL2, CASP3, HMOX1, MAPK14, MTOR, NFE2L2, NOTCH1, PIK3CA, PIK3R6, TP53
dendrite 1 MTOR
phagocytic vesicle 1 MTOR
centrosome 2 NFE2L2, TP53
nucleoplasm 8 AKT1, CASP3, HMOX1, MAPK14, MTOR, NFE2L2, NOTCH1, TP53
RNA polymerase II transcription regulator complex 1 NFE2L2
Cell membrane 6 ABCB1, AKT1, EGFR, NOTCH1, PIK3R6, TNF
Cytoplasmic side 2 HMOX1, MTOR
lamellipodium 2 AKT1, PIK3CA
ruffle membrane 1 EGFR
Early endosome membrane 1 EGFR
Multi-pass membrane protein 1 ABCB1
Golgi apparatus membrane 1 MTOR
cell cortex 1 AKT1
cell junction 1 EGFR
cell surface 5 ABCB1, EGFR, NOTCH1, TNF, VEGFA
glutamatergic synapse 5 AKT1, CASP3, EGFR, MAPK14, NOTCH1
Golgi apparatus 2 NFE2L2, VEGFA
Golgi membrane 4 EGFR, INS, MTOR, NOTCH1
lysosomal membrane 1 MTOR
neuronal cell body 2 CASP3, TNF
postsynapse 1 AKT1
Cytoplasm, cytosol 1 NFE2L2
Lysosome 1 MTOR
acrosomal vesicle 1 NOTCH1
endosome 1 EGFR
plasma membrane 8 ABCB1, AKT1, EGFR, NFE2L2, NOTCH1, PIK3CA, PIK3R6, TNF
Membrane 11 ABCB1, AKT1, BCL2, CYP1B1, EGFR, HMOX1, MTOR, NOTCH1, PIK3R6, TP53, VEGFA
apical plasma membrane 3 ABCB1, EGFR, NOTCH1
basolateral plasma membrane 1 EGFR
caveola 1 PTGS2
extracellular exosome 1 ABCB1
Lysosome membrane 1 MTOR
endoplasmic reticulum 6 BCL2, HMOX1, NOTCH1, PTGS2, TP53, VEGFA
extracellular space 7 EGFR, HMOX1, IL10, IL6, INS, TNF, VEGFA
perinuclear region of cytoplasm 3 EGFR, HMOX1, PIK3CA
Schaffer collateral - CA1 synapse 1 NOTCH1
adherens junction 2 NOTCH1, VEGFA
intercalated disc 1 PIK3CA
mitochondrion 4 BCL2, CYP1B1, MAPK14, TP53
protein-containing complex 5 AKT1, BCL2, EGFR, PTGS2, TP53
intracellular membrane-bounded organelle 1 CYP1B1
Microsome membrane 3 CYP1B1, MTOR, PTGS2
postsynaptic density 1 CASP3
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 2 EGFR, NOTCH1
Secreted 4 IL10, IL6, INS, VEGFA
extracellular region 7 IL10, IL6, INS, MAPK14, NOTCH1, TNF, VEGFA
Mitochondrion outer membrane 2 BCL2, MTOR
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 3 BCL2, HMOX1, MTOR
Mitochondrion matrix 1 TP53
mitochondrial matrix 1 TP53
transcription regulator complex 1 TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 2 BCL2, EGFR
external side of plasma membrane 1 TNF
Secreted, extracellular space, extracellular matrix 1 VEGFA
microtubule cytoskeleton 1 AKT1
nucleolus 1 TP53
cell-cell junction 1 AKT1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
Apical cell membrane 1 ABCB1
Membrane raft 2 EGFR, TNF
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 TP53
focal adhesion 1 EGFR
spindle 1 AKT1
extracellular matrix 1 VEGFA
intracellular vesicle 1 EGFR
Nucleus, PML body 2 MTOR, TP53
PML body 2 MTOR, TP53
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
secretory granule 1 VEGFA
nuclear speck 1 MAPK14
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
receptor complex 2 EGFR, NOTCH1
neuron projection 1 PTGS2
ciliary basal body 1 AKT1
chromatin 2 NFE2L2, TP53
mediator complex 1 NFE2L2
Late endosome membrane 1 NOTCH1
phagocytic cup 1 TNF
spindle pole 1 MAPK14
site of double-strand break 1 TP53
nuclear envelope 1 MTOR
Endomembrane system 1 MTOR
endosome lumen 1 INS
germ cell nucleus 1 TP53
replication fork 1 TP53
myelin sheath 1 BCL2
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 2 INS, MAPK14
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 IL6, INS, PTGS2
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
platelet alpha granule lumen 1 VEGFA
phosphatidylinositol 3-kinase complex 2 PIK3CA, PIK3R6
phosphatidylinositol 3-kinase complex, class IA 2 PIK3CA, PIK3R6
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
postsynaptic density membrane 1 NOTCH1
Single-pass type IV membrane protein 1 HMOX1
clathrin-coated endocytic vesicle membrane 1 EGFR
[Isoform 1]: Nucleus 1 TP53
protein-DNA complex 1 NFE2L2
external side of apical plasma membrane 1 ABCB1
death-inducing signaling complex 1 CASP3
Cytoplasmic vesicle, phagosome 1 MTOR
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
interleukin-6 receptor complex 1 IL6
BAD-BCL-2 complex 1 BCL2
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
phosphatidylinositol 3-kinase complex, class IB 2 PIK3CA, PIK3R6
[Notch 1 intracellular domain]: Nucleus 1 NOTCH1
MAML1-RBP-Jkappa- ICN1 complex 1 NOTCH1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Yuntao Liu, Yuting Zhang, Guoxing You, Danwen Zheng, Zhipeng He, Wenjie Guo, Kim Antonina, Ziyadullaev Shukhrat, Banghan Ding, Jie Zan, Zhongde Zhang. Tangeretin attenuates acute lung injury in septic mice by inhibiting ROS-mediated NLRP3 inflammasome activation via regulating PLK1/AMPK/DRP1 signaling axis. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 2024 Jan; 73(1):47-63. doi: 10.1007/s00011-023-01819-8. [PMID: 38147126]
  • Guoxing You, Linbo Zheng, Yuanyuan Zhang, Yuting Zhang, Yupeng Wang, Wenjie Guo, Hao Liu, Philipovich Tatiana, Kulchitsky Vladimir, Jie Zan. Tangeretin Attenuates Cerebral Ischemia-Reperfusion-Induced Neuronal Pyroptosis by Inhibiting AIM2 Inflammasome Activation via Regulating NRF2. Inflammation. 2023 Sep; ?(?):. doi: 10.1007/s10753-023-01900-8. [PMID: 37725272]
  • Zunli Ke, Si Tan, Haiyang Li, Shanshan Jiang, Yuping Li, Rui Chen, Mingxia Li. Tangeretin improves hepatic steatosis and oxidative stress through the Nrf2 pathway in high fat diet-induced nonalcoholic fatty liver disease mice. Food & function. 2022 Mar; 13(5):2782-2790. doi: 10.1039/d1fo02989d. [PMID: 35171164]
  • Qiyang Chen, Dan Wang, Yue Gu, Zixiao Jiang, Zhiqin Zhou. Tangeretin prevents obesity by modulating systemic inflammation, fat browning, and gut microbiota in high-fat diet-induced obese C57BL/6 mice. The Journal of nutritional biochemistry. 2022 03; 101(?):108943. doi: 10.1016/j.jnutbio.2022.108943. [PMID: 35017003]
  • Yalei Liu, Zhenyu Zhou, Liufang Yin, Mengnan Zhu, Fei Wang, Lijun Zhang, Hongqing Wang, Zhiqin Zhou, Huanhu Zhu, Cheng Huang, Shengjie Fan. Tangeretin promotes lifespan associated with insulin/insulin-like growth factor-1 signaling pathway and heat resistance in Caenorhabditis elegans. BioFactors (Oxford, England). 2022 Mar; 48(2):442-453. doi: 10.1002/biof.1788. [PMID: 34580918]
  • Yue Wang, Rong Jin, Jiebiao Chen, Jinping Cao, Jianbo Xiao, Xian Li, Chongde Sun. Tangeretin maintains antioxidant activity by reducing CUL3 mediated NRF2 ubiquitination. Food chemistry. 2021 Dec; 365(?):130470. doi: 10.1016/j.foodchem.2021.130470. [PMID: 34237577]
  • Meiling Liang, Huijuan Ye, Qing Shen, Xianya Jiang, Guobing Cui, Wenxiang Gu, Lian-Hui Zhang, Naweed I Naqvi, Yi Zhen Deng. Tangeretin inhibits fungal ferroptosis to suppress rice blast. Journal of integrative plant biology. 2021 Dec; 63(12):2136-2149. doi: 10.1111/jipb.13175. [PMID: 34570416]
  • Meng Liu, Shi-Wei Mo, Chun-Li Qin, Bing-Qiang Lyu, Zhi-Qin Zhou, Bing-Hong Gao. [Effects of the combination of tangeretin and whey protein on testosterone and cortisol in sprinters at winter training season]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. 2021 Nov; 37(6):678-682. doi: 10.12047/j.cjap.6100.2021.062. [PMID: 34821105]
  • Ahmed A Al-Karmalawy, Mai M Farid, Ahmed Mostafa, Alia Y Ragheb, Sara H Mahmoud, Mahmoud Shehata, Noura M Abo Shama, Mohamed GabAllah, Gomaa Mostafa-Hedeab, Mona M Marzouk. Naturally Available Flavonoid Aglycones as Potential Antiviral Drug Candidates against SARS-CoV-2. Molecules (Basel, Switzerland). 2021 Oct; 26(21):. doi: 10.3390/molecules26216559. [PMID: 34770969]
  • Pei-Yi Chen, Tzu-Ya Chao, Hao-Jen Hsu, Chih-Yang Wang, Ching-Yen Lin, Wan-Yun Gao, Ming-Jiuan Wu, Jui-Hung Yen. The Lipid-Modulating Effect of Tangeretin on the Inhibition of Angiopoietin-like 3 (ANGPTL3) Gene Expression through Regulation of LXRα Activation in Hepatic Cells. International journal of molecular sciences. 2021 Sep; 22(18):. doi: 10.3390/ijms22189853. [PMID: 34576019]
  • Shuo Lv, Qiyang Chen, Zhenqing Li, Zhiqin Zhou. An evidence update on the protective mechanism of tangeretin against neuroinflammation based on network pharmacology prediction and transcriptomic analysis. European journal of pharmacology. 2021 Sep; 906(?):174094. doi: 10.1016/j.ejphar.2021.174094. [PMID: 34087222]
  • Meng Liu, Shi-Wei Mo, Zhi-Qin Zhou, Bing-Hong Gao. [Effects of Tangeretin on cortisol stress response induced by high-intensity resistance exercise]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. 2021 Sep; 37(5):523-528. doi: 10.12047/j.cjap.6166.2021.055. [PMID: 34816666]
  • Huseyin Fatih Gul, Necip Ilhan, Nevin Ilhan, Ibrahim Hanifi Ozercan, Tuncay Kuloglu. The combined effect of pomegranate extract and tangeretin on the DMBA-induced breast cancer model. The Journal of nutritional biochemistry. 2021 03; 89(?):108566. doi: 10.1016/j.jnutbio.2020.108566. [PMID: 33326843]
  • Yan Hu, Fei Liu, Junxiao Pang, David Julian McClements, Zhiqin Zhou, Bin Li, Yan Li. Biopolymer Additives Enhance Tangeretin Bioavailability in Emulsion-Based Delivery Systems: An In Vitro and In Vivo Study. Journal of agricultural and food chemistry. 2021 Jan; 69(2):730-740. doi: 10.1021/acs.jafc.0c03635. [PMID: 33356230]
  • Sukkum Ngullie Chang, Debasish Kumar Dey, Seong Taek Oh, Won Ho Kong, Kiu Hyung Cho, Ebtesam M Al-Olayan, Buyng Su Hwang, Sun Chul Kang, Jae Gyu Park. Phorbol 12-Myristate 13-Acetate Induced Toxicity Study and the Role of Tangeretin in Abrogating HIF-1α-NF-κB Crosstalk In Vitro and In Vivo. International journal of molecular sciences. 2020 Dec; 21(23):. doi: 10.3390/ijms21239261. [PMID: 33291656]
  • Yue Wang, Yunyi Chen, He Zhang, Jiebiao Chen, Jinping Cao, Qingjun Chen, Xian Li, Chongde Sun. Polymethoxyflavones from citrus inhibited gastric cancer cell proliferation through inducing apoptosis by upregulating RARβ, both in vitro and in vivo. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2020 Dec; 146(?):111811. doi: 10.1016/j.fct.2020.111811. [PMID: 33058988]
  • Xin Huang, Junxiang Zhu, Li Wang, Huijuan Jing, Chaoyang Ma, Xingran Kou, Hongxin Wang. Inhibitory mechanisms and interaction of tangeretin, 5-demethyltangeretin, nobiletin, and 5-demethylnobiletin from citrus peels on pancreatic lipase: Kinetics, spectroscopies, and molecular dynamics simulation. International journal of biological macromolecules. 2020 Dec; 164(?):1927-1938. doi: 10.1016/j.ijbiomac.2020.07.305. [PMID: 32795575]
  • Predeepkumar Narayanappa Shiroorkar, Obaid Afzal, Imran Kazmi, Fahad A Al-Abbasi, Abdulmalik Saleh Alfawaz Altamimi, Kumar Shiva Gubbiyappa, Nagaraja Sreeharsha. Cardioprotective Effect of Tangeretin by Inhibiting PTEN/AKT/mTOR Axis in Experimental Sepsis-Induced Myocardial Dysfunction. Molecules (Basel, Switzerland). 2020 Nov; 25(23):. doi: 10.3390/molecules25235622. [PMID: 33260422]
  • Min-Kyung Kang, Soo-Il Kim, Su Yeon Oh, Woojin Na, Young-Hee Kang. Tangeretin Ameliorates Glucose-Induced Podocyte Injury through Blocking Epithelial to Mesenchymal Transition Caused by Oxidative Stress and Hypoxia. International journal of molecular sciences. 2020 Nov; 21(22):. doi: 10.3390/ijms21228577. [PMID: 33202982]
  • Gopalsamy Rajiv Gandhi, Alan Bruno Silva Vasconcelos, Ding-Tao Wu, Hua-Bin Li, Poovathumkal James Antony, Hang Li, Fang Geng, Ricardo Queiroz Gurgel, Narendra Narain, Ren-You Gan. Citrus Flavonoids as Promising Phytochemicals Targeting Diabetes and Related Complications: A Systematic Review of In Vitro and In Vivo Studies. Nutrients. 2020 Sep; 12(10):. doi: 10.3390/nu12102907. [PMID: 32977511]
  • Petcharat Chiangsaen, Putcharawipa Maneesai, Upa Kukongviriyapan, Terdthai Tong-Un, Wannapa Ishida, Parichat Prachaney, Poungrat Pakdeechote. Tangeretin ameliorates erectile and testicular dysfunction in a rat model of hypertension. Reproductive toxicology (Elmsford, N.Y.). 2020 09; 96(?):1-10. doi: 10.1016/j.reprotox.2020.05.012. [PMID: 32479886]
  • Jianjin Guo, Jinfeng Chen, Wei Ren, Yikun Zhu, Qian Zhao, Kaini Zhang, Dongming Su, Chen Qiu, Wei Zhang, Kai Li. Citrus flavone tangeretin is a potential insulin sensitizer targeting hepatocytes through suppressing MEK-ERK1/2 pathway. Biochemical and biophysical research communications. 2020 08; 529(2):277-282. doi: 10.1016/j.bbrc.2020.05.212. [PMID: 32703423]
  • Akira Nakajima, Kiyomitsu Nemoto, Yasushi Ohizumi. An evaluation of the genotoxicity and subchronic toxicity of the peel extract of Ponkan cultivar 'Ohta ponkan' (Citrus reticulata Blanco) that is rich in nobiletin and tangeretin with anti-dementia activity. Regulatory toxicology and pharmacology : RTP. 2020 Jul; 114(?):104670. doi: 10.1016/j.yrtph.2020.104670. [PMID: 32371103]
  • Konglong Feng, Yaqi Lan, Xiaoai Zhu, Jun Li, Tong Chen, Qingrong Huang, Chi-Tang Ho, Yunjiao Chen, Yong Cao. Hepatic Lipidomics Analysis Reveals the Antiobesity and Cholesterol-Lowering Effects of Tangeretin in High-Fat Diet-Fed Rats. Journal of agricultural and food chemistry. 2020 Jun; 68(22):6142-6153. doi: 10.1021/acs.jafc.0c01778. [PMID: 32394707]
  • Balwinder Singh, Jatinder Pal Singh, Amritpal Kaur, Narpinder Singh. Phenolic composition, antioxidant potential and health benefits of citrus peel. Food research international (Ottawa, Ont.). 2020 06; 132(?):109114. doi: 10.1016/j.foodres.2020.109114. [PMID: 32331689]
  • Milad Ashrafizadeh, Zahra Ahmadi, Reza Mohammadinejad, Elham Ghasemipour Afshar. Tangeretin: a mechanistic review of its pharmacological and therapeutic effects. Journal of basic and clinical physiology and pharmacology. 2020 Apr; 31(4):. doi: 10.1515/jbcpp-2019-0191. [PMID: 32329752]
  • Chutamas Wunpathe, Putcharawipa Maneesai, Siwayu Rattanakanokchai, Sarawoot Bunbupha, Upa Kukongviriyapan, Terdthai Tong-Un, Poungrat Pakdeechote. Tangeretin mitigates l-NAME-induced ventricular dysfunction and remodeling through the AT1R/pERK1/2/pJNK signaling pathway in rats. Food & function. 2020 Feb; 11(2):1322-1333. doi: 10.1039/c9fo02365h. [PMID: 32031202]
  • Rinkiko Suguro, Xiao-Cong Pang, Zhong-Wen Yuan, Si-Yao Chen, Yi-Zhun Zhu, Ying Xie. Combinational applicaton of silybin and tangeretin attenuates the progression of non-alcoholic steatohepatitis (NASH) in mice via modulating lipid metabolism. Pharmacological research. 2020 01; 151(?):104519. doi: 10.1016/j.phrs.2019.104519. [PMID: 31706011]
  • He Bao, Nanbo Zheng, Zhuanting Li, Yuan Zhi. Synergistic Effect of Tangeretin and Atorvastatin for Colon Cancer Combination Therapy: Targeted Delivery of These Dual Drugs Using RGD Peptide Decorated Nanocarriers. Drug design, development and therapy. 2020; 14(?):3057-3068. doi: 10.2147/dddt.s256636. [PMID: 32801644]
  • Mengqin Li, Yan Zhao, Di Qi, Jing He, Daoxin Wang. Tangeretin attenuates lipopolysaccharide-induced acute lung injury through Notch signaling pathway via suppressing Th17 cell response in mice. Microbial pathogenesis. 2020 Jan; 138(?):103826. doi: 10.1016/j.micpath.2019.103826. [PMID: 31676364]
  • Yin Xu, Xiaojian Lv, Guliang Yang, Jianfeng Zhan, Ming Li, Tao Long, Chi-Tang Ho, Shiming Li. Simultaneous separation of six pure polymethoxyflavones from sweet orange peel extract by high performance counter current chromatography. Food chemistry. 2019 Sep; 292(?):160-165. doi: 10.1016/j.foodchem.2019.04.031. [PMID: 31054661]
  • Huijuan Zhang, Guifang Tian, Chengying Zhao, Yanhui Han, Christina DiMarco-Crook, Chang Lu, Yuming Bao, Chengxiu Li, Hang Xiao, Jinkai Zheng. Characterization of polymethoxyflavone demethylation during drying processes of citrus peels. Food & function. 2019 Sep; 10(9):5707-5717. doi: 10.1039/c9fo01053j. [PMID: 31436765]
  • Jie Bai, Shengyu Zhao, Xiaoqing Fan, Yonghui Chen, Xiaowen Zou, Minwan Hu, Baolian Wang, Jing Jin, Xiaojian Wang, Jinping Hu, Dan Zhang, Yan Li. Inhibitory effects of flavonoids on P-glycoprotein in vitro and in vivo: Food/herb-drug interactions and structure-activity relationships. Toxicology and applied pharmacology. 2019 04; 369(?):49-59. doi: 10.1016/j.taap.2019.02.010. [PMID: 30790579]
  • Yue Wang, Wenjing Zang, Shiyu Ji, Jinping Cao, Chongde Sun. Three Polymethoxyflavones Purified from Ougan (Citrus reticulata Cv. Suavissima) Inhibited LPS-Induced NO Elevation in the Neuroglia BV-2 Cell Line via the JAK2/STAT3 Pathway. Nutrients. 2019 Apr; 11(4):. doi: 10.3390/nu11040791. [PMID: 30959824]
  • Yang Liu, Jiakai Han, Zhenyu Zhou, Dandan Li. Tangeretin inhibits streptozotocin-induced cell apoptosis via regulating NF-κB pathway in INS-1 cells. Journal of cellular biochemistry. 2019 03; 120(3):3286-3293. doi: 10.1002/jcb.27596. [PMID: 30216514]
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