Biochanin B (BioDeep_00000270229)

PANOMIX_OTCML-2023

代谢物信息卡片

4H-1-Benzopyran-4-one, 7-hydroxy-3-(4-methoxyphenyl)- (9CI)

化学式: C16H12O4 (268.0735552)
中文名称: 刺芒柄花素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: c1(ccc2c(c1)occ(c2=O)c1ccc(cc1)OC)O
InChI: InChI=1S/C16H12O4/c1-19-12-5-2-10(3-6-12)14-9-20-15-8-11(17)4-7-13(15)16(14)18/h2-9,17H,1H3

描述信息

D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D004967 - Estrogens
Formononetin is a potent FGFR2 inhibitor with an IC50 of ~4.31 μM. Formononetin potently inhibits angiogenesis and tumor growth[1].
Formononetin is a potent FGFR2 inhibitor with an IC50 of ~4.31 μM. Formononetin potently inhibits angiogenesis and tumor growth[1].

同义名列表

54 个代谢物同义名

4H-1-Benzopyran-4-one, 7-hydroxy-3-(4-methoxyphenyl)- (9CI); 4H-1-Benzopyran-4-one, 7-hydroxy-3-(4-methoxyphenyl)-; 7-Hydroxy-3-(4′-methoxyphenyl)-4H-benzopyran-4-one; 7-hydroxy-3-(4-methoxyphenyl)-4H-benzopyran-4-one; 7-hydroxy-3-(4-methoxyphenyl)-4H-chromen-4-one; 7-Hydroxy-3-(4-methoxyphenyl)-4-benzopyrone; Isoflavone, 7-hydroxy-4-methoxy- (8CI); 7-Hydroxy-3-(4-methoxyphenyl)chromone; Isoflavone, 7-hydroxy-4-methoxy-; 7-Hydroxy-4-methoxyisoflavone; SDCCGMLS-0066428.P001; Spectrum4_001429; Spectrum2_000560; Spectrum5_000258; EINECS 207-623-9; Spectrum3_000660; Spectrum_000373; NCGC00095207-03; NCGC00017269-01; SpecPlus_000223; NCGC00095207-02; NCGC00095207-01; NCIOpen2_005983; SPECTRUM102007; KBioGR_001878; BSPBio_002299; Oprea1_139748; Oprea1_815287; DivK1c_006319; KBioSS_000853; ZINC00113304; KBio2_003421; Formononetol; KBio1_001263; SPBio_000639; Formononetin; KBio2_005989; NCI60_042081; KBio3_001519; KBio2_000853; AIDS-027672; CHEBI:18088; 47752_FLUKA; Biochanin B; AIDS027672; SBB016445; NSC 93360; NSC93360; TNP00176; 485-72-3; C00858; 7-Hydroxy-3- (4-methoxyphenyl) -4H-1-benzopyran-4-one; Daidzein 4-methyl ether; Flavosil

数据库引用编号

13 个数据库交叉引用编号

ChEBI: CHEBI:18088
KEGG: C00858
PubChem: 5280378
DrugBank: DB15335
ChEMBL: CHEMBL242341
KNApSAcK: C00002525
CAS: 485-72-3
Flavonoid: FLIA1ANS0001
PubChem: 4115
LipidMAPS: LMPK12050037
3DMET: B00192
NIKKAJI: J12.525C
medchemexpress: HY-N0183

分类词条

黄酮

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

365 个相关的物种来源信息

33090 灯盏细辛: -
33090 鸡血藤: -
33090 沙苑子: -
33090 胡芦巴: -
33090 土荆皮: -
3252 伸筋草: -
33090 枸骨叶: -
33090 山豆根: -
4609 三棱: -
33090 葛根: -
33090 黄芪: -
33090 红芪: -
33090 甘草: -
33090 苦参: -
33090 百部: -
33090 白果: -
33090 降香: -
33090 葛花: -
256638 Euchresta formosana:
1279044 Melilotus messanensis: 10.1016/S0031-9422(98)00453-1
74613 Glycyrrhiza uralensis:
58890 Ononis spinosa:
798039 Ononis speciosa:
147456 Genista sessilifolia: 10.1007/S10600-009-9248-7
3847 Glycine max:
648866 Grona styracifolia: 10.1016/J.PHYTOCHEM.2007.02.015
119829 Astragalus mongholicus:
649199 Astragalus membranaceus:
3827 Cicer arietinum:
242872 Cicer pungens:
242877 Cicer tragacanthoides: 10.1007/BF00629810
242867 Cicer flexuosum:
3897 Styphnolobium japonicum:
242873 Cicer songaricum:
384038 Cyclopia intermedia: 10.1021/JF980258X
149639 Dermatophyllum secundiflorum:
49840 Sophora flavescens:
256637 Sophora tomentosa:
64040 Actaea racemosa:
2507847 Dalbergia sissoides: 10.3906/KIM-1206-45
3860 Lathyrus sativus: 10.1007/BF00630331
361972 Trifolium polyphyllum: 10.1007/BF00577206
49827 Glycyrrhiza glabra:
126911 Ammopiptanthus mongolicus:
37501 Maackia amurensis:
54894 Tipuana tipu:
3880 Medicago truncatula:
3899 Trifolium repens:
57577 Trifolium pratense:
3879 Medicago sativa:
3900 Trifolium subterraneum:
3846 Glycine: 10.1207/S15327914NC5402_5
480422 Butea superba: 10.3987/COM-05-10350
3893 Pueraria montana var. lobata:
149633 Baptisia australis:
60916 Trifolium incarnatum:
47088 Cicer pinnatifidum:
92719 Cicer judaicum:
107682 Cicer chorassanicum:
90897 Cicer echinospermum:
224826 Cicer microphyllum:
92718 Cicer yamashitae:
90898 Cicer reticulatum:
242870 Cicer nuristanicum:
200949 Cicer macracanthum:
90899 Cicer bijugum:
242879 Cicer montbretii:
242878 Cicer anatolicum: 10.1016/S0031-9422(97)00798-X
200948 Cicer canariense:
380786 Cicer rechingeri:
92720 Cicer cuneatum:
242871 Cicer oxyodon:
334483 Syzygium jambos: 10.1002/(SICI)1099-1565(199707)8:4<176::AID-PCA351>3.0.CO;2-K
500182 Centrolobium tomentosum:
500180 Centrolobium robustum:
500181 Centrolobium sclerophyllum:
1929974 Pericopsis laxiflora: 10.1039/P19760000186
499988 Dalbergia odorifera:
450027 Dalbergia monetaria:
1966414 Dalbergia stevensonii:
1353443 Dalbergia candenatensis:
450024 Dalbergia ecastaphyllum:
1353446 Dalbergia cearensis:
1544813 Dalbergia volubilis:
1353466 Dalbergia parviflora:
1353457 Dalbergia inundata:
1225666 Dalbergia lanceolaria:
1353437 Dalbergia baronii:
450026 Dalbergia frutescens:
1353472 Dalbergia spruceana:
1265830 Dalbergia nitidula:
1225674 Derris cuneifolia:
220690 Caragana microphylla: 10.1007/S10600-007-0083-4
132443 Fordia cauliflora: 10.1016/J.CCLET.2010.03.021
339489 Astragalus glaux: 10.1007/978-1-4615-3476-1_53
1460044 Astragalus clusii: 10.1007/978-1-4615-3476-1_53
185975 Wisteria brachybotrys:
119828 Hedysarum polybotrys: 10.1248/CPB.32.3267
56060 Butea monosperma:
450031 Machaerium brasiliense:
2654228 Machaerium aristulatum:
107308 Dalbergia sissoo: 10.1021/NP070478H
1231576 Zollernia paraensis: 10.1016/0031-9422(83)80106-X
167663 Gliricidia sepium: 10.1016/S0031-9422(97)00517-7
119386 Trigonella spicata: 10.1016/0305-1978(82)90048-5
78534 Trigonella foenum-graecum:
70936 Medicago arabica: 10.1016/0305-1978(82)90048-5
70968 Medicago radiata: 10.1016/0305-1978(82)90048-5
390135 Trigonella anguina: 10.1016/0305-1978(82)90048-5
1210111 Trigonella maritima:
1479707 Oxytropis falcata: 10.1021/NP100339U
74614 Glycyrrhiza inflata:
74859 Glycyrrhiza pallidiflora:
46348 Glycyrrhiza echinata:
2785040 Tephrosia maxima: 10.1021/NP50042A015
56065 Pongamia pinnata: 10.1016/J.BMCL.2014.11.015
224910 Virola surinamensis:
53906 Myroxylon balsamum: 10.1016/S0031-9422(00)89391-7
49797 Baptisia tinctoria:
1969224 Baptisia simplicifolia:
1871516 Baptisia perfoliata:
1969220 Baptisia calycosa:
1969221 Baptisia lanceolata:
1969223 Baptisia megacarpa:
313912 Baptisia bracteata:
313914 Baptisia sphaerocarpa:
313911 Baptisia alba:
1969222 Baptisia lecontei:
313913 Baptisia cinerea:
114320 Thermopsis lanceolata: 10.1248/CPB.28.3686
49853 Thermopsis fabacea: 10.1248/CPB.28.3686
3916 Vigna radiata var. radiata: 10.1007/BF00633405
157791 Vigna radiata: 10.1007/BF00633405
318068 Xanthium strumarium: 10.1007/S10600-006-0215-2
58847 Virgilia oroboides:
1712206 Millettia leucantha:
62119 Millettia dura:
1505188 Callerya dielsiana:
185709 Callerya cinerea:
1071200 Pterocarpus soyauxii:
100170 Pterocarpus indicus:
1071187 Pterocarpus marsupium:
862910 Dalbergia cultrata: 10.1021/NP0302450
298683 Dalbergia nigrescens: 10.1021/NP0302450
149628 Amburana cearensis: 10.1590/S0103-50532010000900022
1030150 Dalbergia oliveri: 10.1016/J.PHYTOCHEM.2003.08.010
53825 Andira inermis:
1009002 Ardisia paniculata: 10.1016/J.BMC.2008.12.033
2419554 Hedysarum theinum:
1210108 Trigonella cylindracea: 10.1016/S0305-1978(96)00101-9
119380 Trigonella arabica: 10.1016/S0305-1978(96)00101-9
119388 Trigonella stellata: 10.1016/S0305-1978(96)00101-9
70952 Medicago laciniata: 10.1016/S0305-1978(96)00101-9
70963 Medicago orthoceras: 10.1016/S0305-1978(96)00101-9
390136 Trigonella glabra: 10.1016/S0305-1978(96)00101-9
70965 Medicago polyceratia: 10.1016/S0305-1978(96)00101-9
2805045 Thermopsis mollis: 10.1016/S0031-9422(00)88458-7
114322 Thermopsis macrophylla: 10.1016/S0031-9422(00)88458-7
114325 Thermopsis villosa: 10.1016/S0031-9422(00)88458-7
61122 Thermopsis rhombifolia: 10.1016/S0031-9422(00)88458-7
3888 Pisum sativum: 10.1016/0031-9422(81)80130-6
48131 Amorpha fruticosa:
224864 Pycnanthus angolensis: 10.1021/NP9007393
97032 Trifolium pannonicum: 10.1016/J.TALANTA.2009.03.011
361560 Trifolium arvense: 10.1016/J.TALANTA.2009.03.011
97028 Trifolium medium: 10.1016/J.TALANTA.2009.03.011
97007 Trifolium alpestre:
97037 Trifolium rubens: 10.1016/J.TALANTA.2009.03.011
74522 Trifolium montanum: 10.1021/JF00049A020
97023 Trifolium fragiferum: 10.1021/JF00049A020
53896 Maackia floribunda: 10.1248/CPB.20.2488
238419 Echinospartum horridum: 10.1016/S0031-9422(00)94255-9
54882 Wisteriopsis reticulata: 10.1021/JF903216R
185703 Centrosema pubescens: 10.1515/ZNC-1980-11-1208
167617 Centrosema virginianum: 10.1515/ZNC-1980-11-1208
337842 Cyclopia sessiliflora: 10.1533/9781845698188.5.242
626677 Caragana conferta: 10.1007/S10600-010-9725-Z
97036 Trifolium resupinatum: 10.1007/S10600-007-0206-Y
754915 Taverniera abyssinica: 10.1016/S0031-9422(98)00066-1
455371 Spatholobus suberectus: 10.1016/J.PHYTOCHEM.2006.05.008
3818 Arachis hypogaea: 10.1111/J.1365-3059.1995.TB01679.X
38412 Cladrastis kentukea: 10.1016/S0040-4020(01)82920-3
53857 Cladrastis sikokiana: 10.1016/S0040-4020(01)82920-3
450104 Swartzia polyphylla: 10.1248/CPB.40.2970
3882 Onobrychis viciifolia: 10.1016/S0031-9422(00)91022-7
200959 Trifolium willdenovii: 10.1007/BF00564617
457900 Eysenhardtia polystachya: 10.1300/J044V07N02_03
24962 Castanospermum australe: 10.1071/CH9630188
256638 Euchresta formosana:
1279044 Melilotus messanensis: 10.1016/S0031-9422(98)00453-1
74613 Glycyrrhiza uralensis:
58890 Ononis spinosa:
798039 Ononis speciosa:
147456 Genista sessilifolia: 10.1007/S10600-009-9248-7
3847 Glycine max:
648866 Grona styracifolia: 10.1016/J.PHYTOCHEM.2007.02.015
119829 Astragalus mongholicus:
649199 Astragalus membranaceus:
3827 Cicer arietinum:
242872 Cicer pungens:
242877 Cicer tragacanthoides: 10.1007/BF00629810
242867 Cicer flexuosum:
3897 Styphnolobium japonicum:
242873 Cicer songaricum:
384038 Cyclopia intermedia: 10.1021/JF980258X
149639 Dermatophyllum secundiflorum:
49840 Sophora flavescens:
256637 Sophora tomentosa:
64040 Actaea racemosa:
2507847 Dalbergia sissoides: 10.3906/KIM-1206-45
3860 Lathyrus sativus: 10.1007/BF00630331
361972 Trifolium polyphyllum: 10.1007/BF00577206
49827 Glycyrrhiza glabra:
126911 Ammopiptanthus mongolicus:
37501 Maackia amurensis:
54894 Tipuana tipu:
3880 Medicago truncatula:
3899 Trifolium repens:
57577 Trifolium pratense:
3879 Medicago sativa:
3900 Trifolium subterraneum:
3846 Glycine: 10.1207/S15327914NC5402_5
480422 Butea superba: 10.3987/COM-05-10350
3893 Pueraria montana var. lobata:
149633 Baptisia australis:
60916 Trifolium incarnatum:
47088 Cicer pinnatifidum:
92719 Cicer judaicum:
107682 Cicer chorassanicum:
90897 Cicer echinospermum:
224826 Cicer microphyllum:
92718 Cicer yamashitae:
90898 Cicer reticulatum:
242870 Cicer nuristanicum:
200949 Cicer macracanthum:
90899 Cicer bijugum:
242879 Cicer montbretii:
242878 Cicer anatolicum: 10.1016/S0031-9422(97)00798-X
200948 Cicer canariense:
380786 Cicer rechingeri:
92720 Cicer cuneatum:
242871 Cicer oxyodon:
334483 Syzygium jambos: 10.1002/(SICI)1099-1565(199707)8:4<176::AID-PCA351>3.0.CO;2-K
500182 Centrolobium tomentosum:
500180 Centrolobium robustum:
500181 Centrolobium sclerophyllum:
1929974 Pericopsis laxiflora: 10.1039/P19760000186
499988 Dalbergia odorifera:
450027 Dalbergia monetaria:
1966414 Dalbergia stevensonii:
1353443 Dalbergia candenatensis:
450024 Dalbergia ecastaphyllum:
1353446 Dalbergia cearensis:
1544813 Dalbergia volubilis:
1353466 Dalbergia parviflora:
1353457 Dalbergia inundata:
1225666 Dalbergia lanceolaria:
1353437 Dalbergia baronii:
450026 Dalbergia frutescens:
1353472 Dalbergia spruceana:
1265830 Dalbergia nitidula:
1225674 Derris cuneifolia:
220690 Caragana microphylla: 10.1007/S10600-007-0083-4
132443 Fordia cauliflora: 10.1016/J.CCLET.2010.03.021
339489 Astragalus glaux: 10.1007/978-1-4615-3476-1_53
1460044 Astragalus clusii: 10.1007/978-1-4615-3476-1_53
185975 Wisteria brachybotrys:
119828 Hedysarum polybotrys: 10.1248/CPB.32.3267
56060 Butea monosperma:
450031 Machaerium brasiliense:
2654228 Machaerium aristulatum:
107308 Dalbergia sissoo: 10.1021/NP070478H
1231576 Zollernia paraensis: 10.1016/0031-9422(83)80106-X
167663 Gliricidia sepium: 10.1016/S0031-9422(97)00517-7
119386 Trigonella spicata: 10.1016/0305-1978(82)90048-5
78534 Trigonella foenum-graecum:
70936 Medicago arabica: 10.1016/0305-1978(82)90048-5
70968 Medicago radiata: 10.1016/0305-1978(82)90048-5
390135 Trigonella anguina: 10.1016/0305-1978(82)90048-5
1210111 Trigonella maritima:
1479707 Oxytropis falcata: 10.1021/NP100339U
74614 Glycyrrhiza inflata:
74859 Glycyrrhiza pallidiflora:
46348 Glycyrrhiza echinata:
2785040 Tephrosia maxima: 10.1021/NP50042A015
56065 Pongamia pinnata: 10.1016/J.BMCL.2014.11.015
224910 Virola surinamensis:
53906 Myroxylon balsamum: 10.1016/S0031-9422(00)89391-7
49797 Baptisia tinctoria:
1969224 Baptisia simplicifolia:
1871516 Baptisia perfoliata:
1969220 Baptisia calycosa:
1969221 Baptisia lanceolata:
1969223 Baptisia megacarpa:
313912 Baptisia bracteata:
313914 Baptisia sphaerocarpa:
313911 Baptisia alba:
1969222 Baptisia lecontei:
313913 Baptisia cinerea:
114320 Thermopsis lanceolata: 10.1248/CPB.28.3686
49853 Thermopsis fabacea: 10.1248/CPB.28.3686
3916 Vigna radiata var. radiata: 10.1007/BF00633405
157791 Vigna radiata: 10.1007/BF00633405
318068 Xanthium strumarium: 10.1007/S10600-006-0215-2
58847 Virgilia oroboides:
1712206 Millettia leucantha:
62119 Millettia dura:
1505188 Callerya dielsiana:
185709 Callerya cinerea:
1071200 Pterocarpus soyauxii:
100170 Pterocarpus indicus:
1071187 Pterocarpus marsupium:
862910 Dalbergia cultrata: 10.1021/NP0302450
298683 Dalbergia nigrescens: 10.1021/NP0302450
149628 Amburana cearensis: 10.1590/S0103-50532010000900022
1030150 Dalbergia oliveri: 10.1016/J.PHYTOCHEM.2003.08.010
53825 Andira inermis:
1009002 Ardisia paniculata: 10.1016/J.BMC.2008.12.033
2419554 Hedysarum theinum:
1210108 Trigonella cylindracea: 10.1016/S0305-1978(96)00101-9
119380 Trigonella arabica: 10.1016/S0305-1978(96)00101-9
119388 Trigonella stellata: 10.1016/S0305-1978(96)00101-9
70952 Medicago laciniata: 10.1016/S0305-1978(96)00101-9
70963 Medicago orthoceras: 10.1016/S0305-1978(96)00101-9
390136 Trigonella glabra: 10.1016/S0305-1978(96)00101-9
70965 Medicago polyceratia: 10.1016/S0305-1978(96)00101-9
2805045 Thermopsis mollis: 10.1016/S0031-9422(00)88458-7
114322 Thermopsis macrophylla: 10.1016/S0031-9422(00)88458-7
114325 Thermopsis villosa: 10.1016/S0031-9422(00)88458-7
61122 Thermopsis rhombifolia: 10.1016/S0031-9422(00)88458-7
3888 Pisum sativum: 10.1016/0031-9422(81)80130-6
48131 Amorpha fruticosa:
224864 Pycnanthus angolensis: 10.1021/NP9007393
97032 Trifolium pannonicum: 10.1016/J.TALANTA.2009.03.011
361560 Trifolium arvense: 10.1016/J.TALANTA.2009.03.011
97028 Trifolium medium: 10.1016/J.TALANTA.2009.03.011
97007 Trifolium alpestre:
97037 Trifolium rubens: 10.1016/J.TALANTA.2009.03.011
74522 Trifolium montanum: 10.1021/JF00049A020
97023 Trifolium fragiferum: 10.1021/JF00049A020
53896 Maackia floribunda: 10.1248/CPB.20.2488
238419 Echinospartum horridum: 10.1016/S0031-9422(00)94255-9
54882 Wisteriopsis reticulata: 10.1021/JF903216R
185703 Centrosema pubescens: 10.1515/ZNC-1980-11-1208
167617 Centrosema virginianum: 10.1515/ZNC-1980-11-1208
337842 Cyclopia sessiliflora: 10.1533/9781845698188.5.242
626677 Caragana conferta: 10.1007/S10600-010-9725-Z
97036 Trifolium resupinatum: 10.1007/S10600-007-0206-Y
754915 Taverniera abyssinica: 10.1016/S0031-9422(98)00066-1
455371 Spatholobus suberectus: 10.1016/J.PHYTOCHEM.2006.05.008
3818 Arachis hypogaea: 10.1111/J.1365-3059.1995.TB01679.X
38412 Cladrastis kentukea: 10.1016/S0040-4020(01)82920-3
53857 Cladrastis sikokiana: 10.1016/S0040-4020(01)82920-3
450104 Swartzia polyphylla: 10.1248/CPB.40.2970
3882 Onobrychis viciifolia: 10.1016/S0031-9422(00)91022-7
200959 Trifolium willdenovii: 10.1007/BF00564617
457900 Eysenhardtia polystachya: 10.1300/J044V07N02_03
24962 Castanospermum australe: 10.1071/CH9630188
455371 Spatholobus Suberectus Dunn: -
244311 Erigeron Breviscapus: -
74613 Glycyrrhiza uralensis Fisch.: -
74614 Glycyrrhiza inflata Bat.: -
49827 Glycyrrhiza glabra L.: -
49840 SophorA flavescens Ait.: -
33090 Plants: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Hao-Tian Xu, Qi Zheng, Zong-Guang Tai, Wen-Cheng Jiang, Shao-Qiong Xie, Yue Luo, Xiao-Ya Fei, Ying Luo, Xin Ma, Le Kuai, Ying Zhang, Rui-Ping Wang, Bin Li, Quan-Gang Zhu, Jian-Kun Song. Formononetin attenuates psoriasiform inflammation by regulating interferon signaling pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jun; 128(?):155412. doi: 10.1016/j.phymed.2024.155412. [PMID: 38579666]
Palash Mandal, David A Mortensen, André F Brito, Anna K Wallingford, Marta R M Lima, Nicholas D Warren, Richard G Smith. Water Stress Influences Phytoestrogen Levels in Red Clover (Trifolium pratense) but Not Kura Clover (T. ambiguum). Journal of agricultural and food chemistry. 2024 May; 72(18):10247-10256. doi: 10.1021/acs.jafc.4c00300. [PMID: 38683760]
Jie Luo, Youde Cai, Dingling Wei, Liping Cao, Qiansong He, Yuanhua Wu. Formononetin alleviates cerebral ischemia-reperfusion injury in rats by targeting the PARP-1/PARG/Iduna signaling pathway. Brain research. 2024 Apr; 1829(?):148845. doi: 10.1016/j.brainres.2024.148845. [PMID: 38452845]
Haipeng Chen, Yanmei Lou, Senyi Lin, Xuanjing Tan, Yuting Zheng, Hong Yu, Ruidi Jiang, Yijie Wei, Huijie Huang, Xiaoxiao Qi, Rong Zhang, Zhongqiu Liu, Jinjun Wu. Formononetin, a bioactive isoflavonoid constituent from Astragalus membranaceus (Fisch.) Bunge, ameliorates type 1 diabetes mellitus via activation of Keap1/Nrf2 signaling pathway: An integrated study supported by network pharmacology and experimental validation. Journal of ethnopharmacology. 2024 Mar; 322(?):117576. doi: 10.1016/j.jep.2023.117576. [PMID: 38104880]
Ying He, Youde Cai, Dingling Wei, Liping Cao, Qiansong He, Yazhou Zhang. Elucidating the mechanisms of formononetin in modulating atherosclerotic plaque formation in ApoE-/- mice. BMC cardiovascular disorders. 2024 Feb; 24(1):121. doi: 10.1186/s12872-024-03774-6. [PMID: 38388385]
Jiabao Liao, Xuehua Xie, Ning Wang, Yuming Wang, Jie Zhao, Feng Chen, Fei Qu, Weibo Wen, Jing Miao, Huantian Cui. Formononetin promotes fatty acid β-oxidation to treat non-alcoholic steatohepatitis through SIRT1/PGC-1α/PPARα pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Feb; 124(?):155285. doi: 10.1016/j.phymed.2023.155285. [PMID: 38185065]
Xiaomei Li, Xianhan Jiang, Runhao Zeng, Xiujuan Lai, Jing Wang, Hao Liu, Huihui Wu, Jiaxun He, Lian Liu, Zhiying Zhu, Jingpei Li, Xue Liang. Formononetin attenuates cigarette smoke-induced COPD in mice by suppressing inflammation, endoplasmic reticulum stress, and apoptosis in bronchial epithelial cells via AhR/CYP1A1 and AKT/mTOR signaling pathways. Phytotherapy research : PTR. 2024 Jan; ?(?):. doi: 10.1002/ptr.8104. [PMID: 38191199]
Mi Li, Chengzhi Jiang, Jianting Chen, Junyan Wang. [Formononetin enhances the antitumor effect of H22 hepatoma transplanted mice]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. 2023 Dec; 39(12):1063-1068. doi: . [PMID: 38140864]
Liang Zhang, Qian Wu, Yuying Huang, Jun Zheng, Sheng Guo, Li He. Formononetin ameliorates airway inflammation by suppressing ESR1/NLRP3/Caspase-1 signaling in asthma. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Dec; 168(?):115799. doi: 10.1016/j.biopha.2023.115799. [PMID: 37922653]
Wen Jiang, Ting Hu, Chen Ye, Man Hu, Qingqing Yu, Lijuan Sun, Jichao Liang, Yong Chen. Formononetin attenuates high glucose-induced neurotoxicity by negatively regulating oxidative stress and mitochondrial dysfunction in Schwann cells via activation of SIRT3. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023 Nov; 182(?):114156. doi: 10.1016/j.fct.2023.114156. [PMID: 37944786]
Yu-Zhu Yang, Tao Wang, Qi-Lei Chen, Hu-Biao Chen, Qian-Song He, Ya-Zhou Zhang. Identification of the Metabolites of Both Formononetin in Rat Hepatic S9 and Ononin in Rat Urine Samples and Preliminary Network Pharmacology Evaluation of Their Main Metabolites. Molecules (Basel, Switzerland). 2023 Nov; 28(21):. doi: 10.3390/molecules28217451. [PMID: 37959870]
Zhijing Zhou, Peng Zhang. Formononetin ameliorates the LPS-induced inflammatory response and apoptosis of neuronal cells via NF-κB/NLRP3 signaling pathway. Functional & integrative genomics. 2023 Oct; 23(4):321. doi: 10.1007/s10142-023-01247-1. [PMID: 37847432]
Chun Li, Yuxin Xie, Shaoyu Hu, Hong Yu, Yunke Xu, Hongping Shen, Yuan Yuan, Long Gu, Bangming Pu. Identification of formononetin as the active compound of CR-SR in hepatocellular carcinoma treatment: An integrated approach combining network pharmacology and weighted gene co-expression networks. Chemical biology & drug design. 2023 Oct; ?(?):. doi: 10.1111/cbdd.14363. [PMID: 37793997]
Zi-Wen Zhou, Xue-Yan Zhu, Shu-Ying Li, Si-En Lin, Yu-Han Zhu, Kunmei Ji, Jia-Jie Chen. Formononetin Inhibits Mast Cell Degranulation to Ameliorate Compound 48/80-Induced Pseudoallergic Reactions. Molecules (Basel, Switzerland). 2023 Jul; 28(13):. doi: 10.3390/molecules28135271. [PMID: 37446928]
Tanvi Dayanand Pingale, Girdhari Lal Gupta. Acute & sub-acute toxicity study reveals no dentrimental effect of formononetin in mice upon repeated i.p. dosing. Toxicology mechanisms and methods. 2023 Jul; ?(?):1-17. doi: 10.1080/15376516.2023.2234026. [PMID: 37415263]
Chunhua Zhang, Lingyun Hu, Yun Xie, Jing Wen, Yadi Chen. [Formononetin improves cognitive behavior in aging rats with chronic unpredictable mild in hippocampal tissue stress by blocking the NF-κB pathway and inhibiting the release of inflammatory factors]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. 2023 Jul; 39(7):610-616. doi: . [PMID: 37403720]
Xin Yu, Binkui Yang, Bin Chen, Qi Wu, Zhengrong Ren, Dongsheng Wang, Tao Yuan, Hao Ding, Chao Ding, Yang Liu, Lei Zhang, Zhongyang Sun, Jianning Zhao. Inhibitory effects of Formononetin on CoCrMo particle-induced osteoclast activation and bone loss through downregulating NF-κB and MAPK signaling. Cellular signalling. 2023 Jun; 106(?):110651. doi: 10.1016/j.cellsig.2023.110651. [PMID: 36894124]
Lan-Fang Zhang, Xiao-Yan Zhang, Ai-Cheng Wang, Yi-Jia Feng, Xiao-Ming Qi, Yuan-Lin Zhang, Qing-Fang Li, Yuan-Biao Qiao, Qing-Shan Li. Bidirectional crosstalk of the cAMP/ROS-dependent signaling pathways in inflammatory macrophage: An activation of formononetin. Toxicology and applied pharmacology. 2023 Jun; ?(?):116571. doi: 10.1016/j.taap.2023.116571. [PMID: 37269934]
Adam Yasgar, Danielle Bougie, Richard T Eastman, Ruili Huang, Misha Itkin, Jennifer Kouznetsova, Caitlin Lynch, Crystal McKnight, Mitch Miller, Deborah K Ngan, Tyler Peryea, Pranav Shah, Paul Shinn, Menghang Xia, Xin Xu, Alexey V Zakharov, Anton Simeonov. Quantitative Bioactivity Signatures of Dietary Supplements and Natural Products. ACS pharmacology & translational science. 2023 May; 6(5):683-701. doi: 10.1021/acsptsci.2c00194. [PMID: 37200814]
Gereltsetseg Enkhbat, Kevin J Foster, Phillip G H Nichols, William Erskine, Yoshiaki Inukai, Megan H Ryan. Leaf formononetin content of Trifolium subterraneum increases in response to waterlogging but its proportion of total isoflavones is little changed. Functional plant biology : FPB. 2023 May; ?(?):. doi: 10.1071/fp22151. [PMID: 37142401]
Bingwen Zhu, Yufang Ni, Yi Gong, Xiaoshuang Kang, Huaiying Guo, Xiaoheng Liu, Jianchun Li, Li Wang. Formononetin ameliorates ferroptosis-associated fibrosis in renal tubular epithelial cells and in mice with chronic kidney disease by suppressing the Smad3/ATF3/SLC7A11 signaling. Life sciences. 2023 Feb; 315(?):121331. doi: 10.1016/j.lfs.2022.121331. [PMID: 36586573]
Sandra Yu, Francesco Caruso, Stuart Belli, Miriam Rossi. Scavenging of Superoxide in Aprotic Solvents of Four Isoflavones That Mimic Superoxide Dismutase. International journal of molecular sciences. 2023 Feb; 24(4):. doi: 10.3390/ijms24043815. [PMID: 36835226]
Faryal Rubab, Hira Ijaz, Shah Hussain, Ans Munir, Stefan Stuppner, Thomas Jakschitz, Günther K Bonn, Saiqa Ishtiaq. Gastroprotective effects of Caragana ambigua stocks on ethanol-induced gastric ulcer in rats supported by LC-MS/MS characterization of formononetin and biochanin A. Journal of the science of food and agriculture. 2022 Dec; 102(15):7030-7038. doi: 10.1002/jsfa.12064. [PMID: 35689485]
Jia-Yu Li, Jin-Xin Wang, Qiu-Hao Li, Xiao-Feng Li, Jun-Ping Xiao, Shan-Shan Li, Xiu-Ping Shen, Wei-Dong Zhang, Yun-Heng Shen. Natural borneol enhances the anti-cerebral ischaemia efficacy of formononetin in MCAO/R rats by promoting its delivery in the brain. The Journal of pharmacy and pharmacology. 2022 Nov; 74(11):1598-1608. doi: 10.1093/jpp/rgac070. [PMID: 36106815]
Xinru Zhang-Peng, Hong Wei, Jing Ma, Yuanyuan Li, Yan Chen, Fang Cui, Fangdi Hu, Yongling Du. Molecularly imprinted flexible sensor based on nitrogen-doped graphene for selective determination of formononetin. Journal of pharmaceutical and biomedical analysis. 2022 Aug; 217(?):114805. doi: 10.1016/j.jpba.2022.114805. [PMID: 35580480]
Changjing Zhang, Leilei Zhu, Shuaifei Lu, Mengyuan Li, Ming Bai, Yucheng Li, Erping Xu. The antidepressant-like effect of formononetin on chronic corticosterone-treated mice. Brain research. 2022 05; 1783(?):147844. doi: 10.1016/j.brainres.2022.147844. [PMID: 35218705]
Li Yu, Yangyang Zhang, Qianqian Chen, Yu He, Huifen Zhou, Haitong Wan, Jiehong Yang. Formononetin protects against inflammation associated with cerebral ischemia-reperfusion injury in rats by targeting the JAK2/STAT3 signaling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 May; 149(?):112836. doi: 10.1016/j.biopha.2022.112836. [PMID: 35339827]
Jing Ying Wang, Ming Wen Jiang, Ming Yue Li, Zhi Hong Zhang, Yue Xing, MyongHak Ri, Cheng Hua Jin, Guang Hua Xu, Lian Xun Piao, Hong Lan Jin, Juan Ma, Yong Jin, Hong Xiang Zuo, Xuejun Jin. Formononetin represses cervical tumorigenesis by interfering with the activation of PD-L1 through MYC and STAT3 downregulation. The Journal of nutritional biochemistry. 2022 02; 100(?):108899. doi: 10.1016/j.jnutbio.2021.108899. [PMID: 34748924]
Lanjie Yi, Yan Lu, Shun Yu, Qian Cheng, Lanjuan Yi. Formononetin inhibits inflammation and promotes gastric mucosal angiogenesis in gastric ulcer rats through regulating NF-κB signaling pathway. Journal of receptor and signal transduction research. 2022 Feb; 42(1):16-22. doi: 10.1080/10799893.2020.1837873. [PMID: 33100111]
Zhongxiao Zhou, Haimeng Zhou, Xin Zou, Xiaowei Wang, Mengjun Yan. Formononetin regulates endothelial nitric oxide synthase to protect vascular endothelium in deep vein thrombosis rats. International journal of immunopathology and pharmacology. 2022 Jan; 36(?):3946320221111117. doi: 10.1177/03946320221111117. [PMID: 35731855]
Mahrukh Naudhani, Kiran Thakur, Zhi-Jing Ni, Jian-Guo Zhang, Zhao-Jun Wei. Formononetin reshapes the gut microbiota, prevents progression of obesity and improves host metabolism. Food & function. 2021 Dec; 12(24):12303-12324. doi: 10.1039/d1fo02942h. [PMID: 34821251]
Juanjuan Huang, Xianfeng Chen, Aihua Xie. Formononetin ameliorates IL‑13‑induced inflammation and mucus formation in human nasal epithelial cells by activating the SIRT1/Nrf2 signaling pathway. Molecular medicine reports. 2021 Dec; 24(6):. doi: 10.3892/mmr.2021.12472. [PMID: 34590155]
Baohua Zhang, Zhongwei Hao, Wenli Zhou, Shan Zhang, Mingyan Sun, Honglei Li, Naijing Hou, Cui Jing, Mingxing Zhao. Formononetin protects against ox-LDL-induced endothelial dysfunction by activating PPAR-γ signaling based on network pharmacology and experimental validation. Bioengineered. 2021 12; 12(1):4887-4898. doi: 10.1080/21655979.2021.1959493. [PMID: 34369277]
Shaza H Aly, Ahmed M Elissawy, Ahmed M Fayez, Omayma A Eldahshan, Mohamed A Elshanawany, Abdel Nasser B Singab. Neuroprotective effects of Sophora secundiflora, Sophora tomentosa leaves and formononetin on scopolamine-induced dementia. Natural product research. 2021 Dec; 35(24):5848-5852. doi: 10.1080/14786419.2020.1795853. [PMID: 32696670]
Zhanding Cui, Qian Wang, Dengliang Li, Shihui Zhao, Qian Zhang, Yuxin Tan, Qianwen Gong, Ting Liu, Jiang Shao, Shuang Zhang, Hailong Huang, Junzheng Wang, Zhihua Pei, Hao Dong, Kai Wang, Guixue Hu, Zhiyong Li. Icariin, Formononetin and Caffeic Acid Phenethyl Ester Inhibit Feline Calicivirus Replication In Vitro. Archives of virology. 2021 Sep; 166(9):2443-2450. doi: 10.1007/s00705-021-05107-w. [PMID: 34173062]
Jingjing Wu, Wen Xu, Lina Ma, Jiayu Sheng, Meina Ye, Hao Chen, Yuzhu Zhang, Bing Wang, Mingjuan Liao, Tian Meng, Yue Zhou, Hongfeng Chen. Formononetin relieves the facilitating effect of lncRNA AFAP1-AS1-miR-195/miR-545 axis on progression and chemo-resistance of triple-negative breast cancer. Aging. 2021 07; 13(14):18191-18222. doi: 10.18632/aging.203156. [PMID: 34289449]
Young-A Lee, Yu-Jeong Kim, Ju Sung Lee, Sanghyun Lee, Yukiori Goto. Imbalance between dopamine and serotonin caused by neonatal habenula lesion. Behavioural brain research. 2021 07; 409(?):113316. doi: 10.1016/j.bbr.2021.113316. [PMID: 33901435]
Ling Li, Xiao-Jie Jin, Jia-Wei Li, Cheng-Hao Li, Shuang-Yan Zhou, Jun-Jie Li, Cai-Qin Feng, Dong-Ling Liu, Yong-Qi Liu. Systematic insight into the active constituents and mechanism of Guiqi Baizhu for the treatment of gastric cancer. Cancer science. 2021 May; 112(5):1772-1784. doi: 10.1111/cas.14851. [PMID: 33682294]
Randy D Dinkins, Julie Hancock, Brenda L Coe, John B May, Jack P Goodman, William T Bass, Jinge Liu, Yinglun Fan, Qiaolin Zheng, Hongyan Zhu. Isoflavone levels, nodulation and gene expression profiles of a CRISPR/Cas9 deletion mutant in the isoflavone synthase gene of red clover. Plant cell reports. 2021 Mar; 40(3):517-528. doi: 10.1007/s00299-020-02647-4. [PMID: 33389047]
Weiyuan Yuan, Yanyan Chen, Yijing Zhou, Kaifan Bao, Xuerui Yu, Yifan Xu, Yuheng Zhang, Jie Zheng, Guorong Jiang, Min Hong. Formononetin attenuates atopic dermatitis by upregulating A20 expression via activation of G protein-coupled estrogen receptor. Journal of ethnopharmacology. 2021 Feb; 266(?):113397. doi: 10.1016/j.jep.2020.113397. [PMID: 32971159]
Lingyu Liu, Rong Hu, Haiyan You, Jingjing Li, Yangyang Liu, Qiang Li, Xiaohui Wu, Jiawen Huang, Xiangsheng Cai, Mingqing Wang, Lianbo Wei. Formononetin ameliorates muscle atrophy by regulating myostatin-mediated PI3K/Akt/FoxO3a pathway and satellite cell function in chronic kidney disease. Journal of cellular and molecular medicine. 2021 02; 25(3):1493-1506. doi: 10.1111/jcmm.16238. [PMID: 33405354]
Yan Hao, Jie Miao, Wenjia Liu, Li Peng, Yue Chen, Qing Zhong. Formononetin protects against cisplatin‑induced acute kidney injury through activation of the PPARα/Nrf2/HO‑1/NQO1 pathway. International journal of molecular medicine. 2021 02; 47(2):511-522. doi: 10.3892/ijmm.2020.4805. [PMID: 33416097]
Mutaib M Mashraqi, Navaneet Chaturvedi, Qamre Alam, Saleh Alshamrani, Mosa M Bahnass, Khurshid Ahmad, Amany I Alqosaibi, Mashael M Alnamshan, Syed Sayeed Ahmad, Mirza Masroor Ali Beg, Abha Mishra, Sibhghatulla Shaikh, Syed Mohd Danish Rizvi. Biocomputational Prediction Approach Targeting FimH by Natural SGLT2 Inhibitors: A Possible Way to Overcome the Uropathogenic Effect of SGLT2 Inhibitor Drugs. Molecules (Basel, Switzerland). 2021 Jan; 26(3):. doi: 10.3390/molecules26030582. [PMID: 33499241]
Yin Chen, Dong Wei, Jin Zhao, Xiangnan Xu, Jingyu Chen. Reduction of hyperoxic acute lung injury in mice by Formononetin. PloS one. 2021; 16(1):e0245050. doi: 10.1371/journal.pone.0245050. [PMID: 33411783]
Yuan Fang, Juan Ye, Bing Zhao, Jinbing Sun, Na Gu, Xi Chen, Lingli Ren, Jiao Chen, Xueting Cai, Wenjuan Zhang, Yang Yang, Peng Cao. Formononetin ameliorates oxaliplatin-induced peripheral neuropathy via the KEAP1-NRF2-GSTP1 axis. Redox biology. 2020 09; 36(?):101677. doi: 10.1016/j.redox.2020.101677. [PMID: 32823168]
Peng Zhang, Han Ma, Xiaolan Lin, Feng Qiu. Simultaneous quantification and rat pharmacokinetics of formononetin-7-O-β-d-glucoside and its metabolite formononetin by high-performance liquid chromatography-tandem mass spectrometry. Journal of separation science. 2020 Aug; 43(15):2996-3005. doi: 10.1002/jssc.202000291. [PMID: 32431050]
Wei-Yuan Yuan, Lian-Qu Li, Yan-Yan Chen, Yi-Jing Zhou, Kai-Fan Bao, Jie Zheng, Yong-Qing Hua, Guo-Rong Jiang, Min Hong. Frontline Science: Two flavonoid compounds attenuate allergic asthma by regulating epithelial barrier via G protein-coupled estrogen receptor: Probing a possible target for allergic inflammation. Journal of leukocyte biology. 2020 07; 108(1):59-71. doi: 10.1002/jlb.3hi0220-342rr. [PMID: 32303124]
Weie Zhou, Hanqiu Wu, Qian Wang, Xuefeng Zhou, Yuan Zhang, Wenjie Wu, Yuyang Wang, Zhiqin Ren, Hongna Li, Yun Ling, Feng Zhang, Ping Li. Simultaneous determination of formononetin, biochanin A and their active metabolites in human breast milk, saliva and urine using salting-out assisted liquid-liquid extraction and ultra high performance liquid chromatography-electrospray ionization tandem mass spectrum. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2020 May; 1145(?):122108. doi: 10.1016/j.jchromb.2020.122108. [PMID: 32305709]
Gari Vidal Ccana-Ccapatinta, Jennyfer Andrea Aldana Mejía, Matheus Hikaru Tanimoto, Milton Groppo, Jean Carlos Andrade Sarmento de Carvalho, Jairo Kenupp Bastos. Dalbergia ecastaphyllum (L.) Taub. and Symphonia globulifera L.f.: The Botanical Sources of Isoflavonoids and Benzophenones in Brazilian Red Propolis. Molecules (Basel, Switzerland). 2020 Apr; 25(9):. doi: 10.3390/molecules25092060. [PMID: 32354180]
Wei-Chen Xiong, He-Zhen Wu, Yi-Yi Xiong, Bo Liu, Zhou-Tao Xie, Song-Tao Wu, Yun-Feng Yao, Yan-Fang Yang. Network Pharmacology-based Research of Active Components of Albiziae Flos and Mechanisms of Its Antidepressant Effect. Current medical science. 2020 Feb; 40(1):123-129. doi: 10.1007/s11596-020-2155-7. [PMID: 32166674]
Yi-Bo Hong, Hong Jiang, Jian-Wei Wang, Peng-Fei Yu, Wu-Lin You. [Experimental study on the inhibition of Formononetin on the differentiation of osteoclasts induced by RANKL]. Zhongguo gu shang = China journal of orthopaedics and traumatology. 2020 Jan; 33(1):64-70. doi: 10.3969/j.issn.1003-0034.2020.01.012. [PMID: 32115927]
Xiangsheng Zhao, Shihui Zhang, Dan Liu, Meihua Yang, Jianhe Wei. Analysis of Flavonoids in Dalbergia odorifera by Ultra-Performance Liquid Chromatography with Tandem Mass Spectrometry. Molecules (Basel, Switzerland). 2020 Jan; 25(2):. doi: 10.3390/molecules25020389. [PMID: 31963485]
Liuting Wei, Pingchuan Zhu, Xiaoqing Chen, Yilin Wang, Yuanjin Xu. An ultra high performance liquid chromatography with tandem mass spectrometry method for simultaneous determination of thirteen components extracted from Radix Puerariae in rat plasma and tissues: Application to pharmacokinetic and tissue distribution study. Journal of separation science. 2020 Jan; 43(2):418-437. doi: 10.1002/jssc.201900824. [PMID: 31650695]
Chuanrui Ma, Ronglin Xia, Shu Yang, Lipei Liu, Jing Zhang, Ke Feng, Yuna Shang, Jingtian Qu, Lingwei Li, Ning Chen, Shixin Xu, Wenwen Zhang, Jingyuan Mao, Jihong Han, Yuanli Chen, Xiaoxiao Yang, Yajun Duan, Guanwei Fan. Formononetin attenuates atherosclerosis via regulating interaction between KLF4 and SRA in apoE-/- mice. Theranostics. 2020; 10(3):1090-1106. doi: 10.7150/thno.38115. [PMID: 31938053]
Shin-Ichiro Yokoyama, Miyuki Kodera, Akiko Hirai, Mitsuhiko Nakada, Yuki Ueno, Toshihiko Osawa. Red Clover (Trifolium pratense L.) Sprout Prevents Metabolic Syndrome. Journal of nutritional science and vitaminology. 2020; 66(1):48-53. doi: 10.3177/jnsv.66.48. [PMID: 32115453]
Jessé V Dos Santos, Paula R A Ribeiro, Maria Angélica B Carneiro, Isaac C Soares, Ivan V A Fiorini, Leandro L Cancellier, Adriano D Veiga, Carlos Juliano B Albuquerque, Renzo G VON Pinho, Fatima M S Moreira. Formononetin accelerates mycorrhization and increases maize production at low phosphorus application rates. Anais da Academia Brasileira de Ciencias. 2020; 92 Suppl 1(?):e20181371. doi: 10.1590/0001-3765202020181371. [PMID: 32491139]
Xin Li, Chen Huang, Cheng Liang Sui, Chun Mei Liang, Guang Ying Qi, Qian Yao Ren, Jian Chen, Zhao Quan Huang. Formononetin, J1 and J2 have different effects on endothelial cells via EWSAT1-TRAF6 and its downstream pathway. Journal of cellular and molecular medicine. 2020 01; 24(1):875-885. doi: 10.1111/jcmm.14797. [PMID: 31742893]
Liyu Luo, Junyi Zhou, Haiyu Zhao, Miaoxuan Fan, Wenyuan Gao. The anti-inflammatory effects of formononetin and ononin on lipopolysaccharide-induced zebrafish models based on lipidomics and targeted transcriptomics. Metabolomics : Official journal of the Metabolomic Society. 2019 11; 15(12):153. doi: 10.1007/s11306-019-1614-2. [PMID: 31768751]
Gonzalo R Malca Garcia, J Brent Friesen, Yang Liu, Dejan Nikolić, David C Lankin, James B McAlpine, Shao-Nong Chen, Guido F Pauli. Preparation of DESIGNER extracts of red clover (Trifolium pratense L.) by centrifugal partition chromatography. Journal of chromatography. A. 2019 Nov; 1605(?):360277. doi: 10.1016/j.chroma.2019.05.057. [PMID: 31307793]
Yan Wang, Hailing Zhao, Xin Li, Qian Wang, Meihua Yan, Haojun Zhang, Tingting Zhao, Nannan Zhang, Pan Zhang, Liang Peng, Ping Li. Formononetin alleviates hepatic steatosis by facilitating TFEB-mediated lysosome biogenesis and lipophagy. The Journal of nutritional biochemistry. 2019 11; 73(?):108214. doi: 10.1016/j.jnutbio.2019.07.005. [PMID: 31520816]
Kanumuri Siva Rama Raju, Mamunur Rashid, Manoj Gundeti, Isha Taneja, Mohd Yaseen Malik, Sandeep Kumar Singh, Swati Chaturvedi, Muralikrishna Challagundla, Sheelendra Pratap Singh, J R Gayen, Muhammad Wahajuddin. LC-ESI-MS/MS method for the simultaneous determination of isoformononetin, daidzein, and equol in rat plasma: Application to a preclinical pharmacokinetic study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2019 Oct; 1129(?):121776. doi: 10.1016/j.jchromb.2019.121776. [PMID: 31629309]
Mingya Ding, Wenfang Ma, Xiaoyan Wang, Shujing Chen, Shuhan Zou, Jinna Wei, Yuqiao Yang, Jin Li, Xuejing Yang, Hui Wang, Yuhong Li, Qilong Wang, Haoping Mao, Xiu-Mei Gao, Yan-Xu Chang. A network pharmacology integrated pharmacokinetics strategy for uncovering pharmacological mechanism of compounds absorbed into the blood of Dan-Lou tablet on coronary heart disease. Journal of ethnopharmacology. 2019 Oct; 242(?):112055. doi: 10.1016/j.jep.2019.112055. [PMID: 31276751]
Qi Ni, Yani Fan, Xiong Zhang, Hongwei Fan, Yingbin Li. In vitro and in vivo Study on Glioma Treatment Enhancement by Combining Temozolomide with Calycosin and Formononetin. Journal of ethnopharmacology. 2019 Oct; 242(?):111699. doi: 10.1016/j.jep.2019.01.023. [PMID: 31005632]
Tai Rao, Yu-Feng Gong, Jing-Bo Peng, Yi-Cheng Wang, Kang He, Hong-Hao Zhou, Zhi-Rong Tan, Li-Zhi Lv. Comparative pharmacokinetic study on three formulations of Astragali Radix by an LC-MS/MS method for determination of formononetin in human plasma. Biomedical chromatography : BMC. 2019 Sep; 33(9):e4563. doi: 10.1002/bmc.4563. [PMID: 31025385]
Kuan Chen, Zhi-Min Hu, Wei Song, Zi-Long Wang, Jun-Bin He, Xiao-Meng Shi, Qing-Hua Cui, Xue Qiao, Min Ye. Diversity of O-Glycosyltransferases Contributes to the Biosynthesis of Flavonoid and Triterpenoid Glycosides in Glycyrrhiza uralensis. ACS synthetic biology. 2019 08; 8(8):1858-1866. doi: 10.1021/acssynbio.9b00171. [PMID: 31284719]
Qing-Yan Gai, Jiao Jiao, Xin Wang, Jing Liu, Zi-Ying Wang, Yu-Jie Fu. Chitosan promoting formononetin and calycosin accumulation in Astragalus membranaceus hairy root cultures via mitogen-activated protein kinase signaling cascades. Scientific reports. 2019 07; 9(1):10367. doi: 10.1038/s41598-019-46820-6. [PMID: 31316129]
Hai Xiao, Xinyue Qin, Jinping Wan, Rong Li. Pharmacological Targets and the Biological Mechanisms of Formononetin for Alzheimer's Disease: A Network Analysis. Medical science monitor : international medical journal of experimental and clinical research. 2019 Jun; 25(?):4273-4277. doi: 10.12659/msm.916662. [PMID: 31175839]
Shu Yang, Lingling Wei, Ronglin Xia, Lipei Liu, Yuanli Chen, Wenwen Zhang, Qi Li, Ke Feng, Miao Yu, Wei Zhang, Jingtian Qu, Shixin Xu, Jingyuan Mao, Guanwei Fan, Chuanrui Ma. Formononetin ameliorates cholestasis by regulating hepatic SIRT1 and PPARα. Biochemical and biophysical research communications. 2019 05; 512(4):770-778. doi: 10.1016/j.bbrc.2019.03.131. [PMID: 30928103]
Wei Hu, Xianpei Wu, Jiandong Tang, Guoping Zhao, Niansu Xiao, Li Zhang, Sen Li. Anti-cancer targets of formononetin and molecular mechanisms in osteosarcoma: Findings of bioinformatic and experimental assays. Journal of cellular and molecular medicine. 2019 05; 23(5):3505-3511. doi: 10.1111/jcmm.14248. [PMID: 30873755]
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