Oxymatrine (BioDeep_00000002601)

 

Secondary id: BioDeep_00000893711

PANOMIX_OTCML-2023


代谢物信息卡片


1H,5H,10H-Dipyrido(2,1-f:3,2,1-ij)(1,6)naphthyridin-10-one, dodecahydro-, 4-oxide, (4R,7aS,13aR,13bR,13cS)-

化学式: C15H24N2O2 (264.18376839999996)
中文名称: 氧化苦参碱, 氧化槐定碱, 苦参素, 氧化槐定碱, 氧化苦参碱
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 0.63%

分子结构信息

SMILES: C1CC2C3CCC[N+]4(C3C(CCC4)CN2C(=O)C1)[O-]
InChI: InChI=1S/C15H24N2O2/c18-14-7-1-6-13-12-5-3-9-17(19)8-2-4-11(15(12)17)10-16(13)14/h11-13,15H,1-10H2/t11-,12+,13+,15-,17+/m0/s1

描述信息

Ammothamnine is an alkaloid and a tertiary amine oxide.
Oxymatrine is a natural product found in Sophora pachycarpa, Sophora chrysophylla, and other organisms with data available.
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents
Origin: Plant; SubCategory_DNP: Alkaloids derived from lysine, Quinolizidine alkaloids, Sophora alkaloid
Oxymatrine is under investigation in clinical trial NCT02202473 (Oxymatrine Plus Lamivudine Combination Therapy Versus Lamivudine Monotherapy for Chronic Hepatitis B Infected Subjects).
Matrine oxide is a natural product found in Daphniphyllum oldhamii, Sophora viciifolia, and other organisms with data available.
Oxymatrine, an alkaloid from Sophora flavescens Alt. with anti-inflammatory, antifibrosis, and antitumor effects, inhibits the iNOS expression and TGF-β/Smad pathway. Oxymatrine inhibits bocavirus minute virus of canines (MVC) replication, reduces viral gene expression and decreases apoptosis induced by viral infection.
Oxymatrine, an alkaloid from Sophora flavescens Alt. with anti-inflammatory, antifibrosis, and antitumor effects, inhibits the iNOS expression and TGF-β/Smad pathway. Oxymatrine inhibits bocavirus minute virus of canines (MVC) replication, reduces viral gene expression and decreases apoptosis induced by viral infection.
Oxysophoridine (Sophoridine N-oxide) is a bioactive alkaloid extracted from the Sophora alopecuroides Linn. Oxysophoridine (Sophoridine N-oxide) shows anti inflammatory, anti oxidative stress and anti apoptosis effects[1][2].
Oxysophoridine (Sophoridine N-oxide) is a bioactive alkaloid extracted from the Sophora alopecuroides Linn. Oxysophoridine (Sophoridine N-oxide) shows anti inflammatory, anti oxidative stress and anti apoptosis effects[1][2].

同义名列表

28 个代谢物同义名

1H,5H,10H-Dipyrido[2,1-f:3,2,1-ij][1,6]naphthyridin-10-one,dodecahydro-, 4-oxide, (7aR,13aR,13bR,13cS)-; (7aS,13aR,13bR,13cS)dodecahydro-1H,5H,10H-dipyrido[2,1-f:3,2,1-ij][1,6]naphthyridin-10-one 4-oxide; rel-(41S,7aS,13aR,13bR)-10-Oxohexadecahydrodipyrido[2,1-f:3,2,1-ij][1,6]naphthyridine 4-oxide; rel-(41S,7aS,13aR,13bR)-10-Oxohexadecahydrodipyrido[2,1-f:3,2,1-ij][1,6]naphthyridine4-oxide; (1R,2R,9S,13R,17S)-13-Oxido-7-aza-13-azoniatetracyclo[7.7.1.02,7.013,17]heptadecan-6-one; (1R,2R,9S,17S)-6-oxo-7,13-diazatetracyclo[7.7.1.0?,?.0??,??]heptadecan-13-ium-13-olate; (1R,2R,9S,17S)-13-oxido-7-aza-13-azoniatetracyclo[7.7.1.02,7.013,17]heptadecan-6-one; Oxymatrine (Matrine N-oxide); XVPBINOPNYFXID-LHDUFFHYSA-N; Sophoridine N-oxide; Matrine 1beta-oxide; (+)-Matrine N-oxide; Matrine N-oxide; Pachycarpidine; (+)-oxymatrine; Oxysophoridine; Oxymatrine,(S); Matrine oxide; Ammothamnine; Oxymatrine; 1H,5H,10H-Dipyrido(2,1-f:3,2,1-ij)(1,6)naphthyridin-10-one, dodecahydro-, 4-oxide, (4R,7aS,13aR,13bR,13cS)-; (4R,7AS,13AR,13BR,13CS)-DODECAHYDRO-1H,5H,10H-DIPYRIDO(2,1-F:3,2,1-IJ)(1,6)NAPHTHYRIDIN-10-ONE 4-OXIDE; (7AS,13AR,13BR,13CS)-DODECAHYDRO-1H,5H,10H-DIPYRIDO(2,1-F:3,2,1-IJ)(1,6)NAPHTHYRIDIN-10-ONE 4-OXIDE; Matridin-15-one, 1-oxide, (1-beta)-; OXYMATRINE [WHO-DD]; Matrine, 1-oxide; UNII-85U4C366QS; 85U4C366QS



数据库引用编号

29 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yan Zhi, Xinping Zhao, Zhenyi Liu, Guoyu Shen, Taiming Zhang, Tao Zhang, Ge Hu. Oxymatrine Modulation of TLR3 Signaling: A Dual-Action Mechanism for H9N2 Avian Influenza Virus Defense and Immune Regulation. Molecules (Basel, Switzerland). 2024 Apr; 29(9):. doi: 10.3390/molecules29091945. [PMID: 38731436]
  • Jinying Lu, Jiang Bian, Yutong Wang, Yan Zhao, Xinmin Zhao, Gao Wang, Jing Yang. Oxymatrine protects articular chondrocytes from IL-1β-induced damage through autophagy activation via AKT/mTOR signaling pathway inhibition. Journal of orthopaedic surgery and research. 2024 Mar; 19(1):178. doi: 10.1186/s13018-024-04667-2. [PMID: 38468339]
  • Ashmita Das, Onkar Kashyap, Devi P Pandey, Surendra H Bodakhe. Oxymatrine impedes the progression of endotoxin-induced glaucoma via redox system modulations. Journal of biochemical and molecular toxicology. 2024 Jan; 38(1):e23631. doi: 10.1002/jbt.23631. [PMID: 38229309]
  • Chen He, Wenjing Wang, Guoli Wei, Yuqing Wang, Yingjie Wei, Jing Wang, Zhenhai Zhang. Sodium alginate combined with oxymatrine ameliorates CCl4-induced chemical hepatic fibrosis in mice. International immunopharmacology. 2023 Nov; 125(Pt A):111144. doi: 10.1016/j.intimp.2023.111144. [PMID: 37922569]
  • Benjamin Christian Fischer, Yemurai Musengi, Jeannette König, Benjamin Sachse, Stefanie Hessel-Pras, Bernd Schäfer, Carsten Kneuer, Kristin Herrmann. Matrine and Oxymatrine: Evaluating the gene mutation potential using in silico tools and the bacterial reverse mutation assay (Ames test). Mutagenesis. 2023 Oct; ?(?):. doi: 10.1093/mutage/gead032. [PMID: 37877816]
  • Hong Wang, Liangyin Wei, Dengxuan Mao, Xiaoyu Che, Xietao Ye, Yuping Liu, Yan Chen. Combination of oxymatrine (Om) and astragaloside IV (As) enhances the infiltration and function of TILs in triple-negative breast cancer (TNBC). International immunopharmacology. 2023 Oct; 125(Pt A):111026. doi: 10.1016/j.intimp.2023.111026. [PMID: 37866315]
  • Gan Cao, Zhuhan Mao, Tengyao Niu, Peipei Wang, Xiaoqi Yue, Xuemei Wang, Ailing Ma, Yanli Zhang. Oxymatrine ameliorates rheumatoid arthritis by regulation of Tfr/Tfh cells balance via TLR9-MyD88-STAT3 signaling pathway. Journal of the science of food and agriculture. 2023 May; ?(?):. doi: 10.1002/jsfa.12674. [PMID: 37128150]
  • Li Liang, Weiliang Sun, Xiaoxuan Wei, Li Wang, Huaqiang Ruan, Junchuan Zhang, Suyan Li, Bi Zhao, Mengshi Li, Zhengwen Cai, Jie'an Huang. Oxymatrine suppresses colorectal cancer progression by inhibiting NLRP3 inflammasome activation through mitophagy induction in vitro and in vivo. Phytotherapy research : PTR. 2023 Mar; ?(?):. doi: 10.1002/ptr.7808. [PMID: 36974424]
  • Xiao-Bing Lan, Yuan-Shu Ni, Ning Liu, Wei Wei, Yue Liu, Jia-Mei Yang, Lin Ma, Ru Bai, Jian Zhang, Jian-Qiang Yu. Neuroprotective effects of oxymatrine on hypoxic-ischemic brain damage in neonatal rats by activating the Wnt/β-catenin pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Mar; 159(?):114266. doi: 10.1016/j.biopha.2023.114266. [PMID: 36652736]
  • Luping Ren, Xuehua Liu, Xitong Huang, He Zhang, Wenjie Fei, Xian Yu, Zhijuan Hu, Yunfeng Zhen, Shuchun Chen. Oxymatrine relieves high-fructose/fat-induced obesity via reprogramming the activity of lipid metabolism-related enhancer. Frontiers in endocrinology. 2023; 14(?):1145575. doi: 10.3389/fendo.2023.1145575. [PMID: 37600712]
  • Jing Li, Jianhao Liang, Meiqin Zeng, Kaijian Sun, Yunhao Luo, Huaping Zheng, Feng Li, Wen Yuan, Hongwei Zhou, Junshan Liu, Haitao Sun. Oxymatrine ameliorates white matter injury by modulating gut microbiota after intracerebral hemorrhage in mice. CNS neuroscience & therapeutics. 2022 Dec; ?(?):. doi: 10.1111/cns.14066. [PMID: 36550632]
  • Renhui Luo, Lili Xie, Yingmei Lin, Jun Shao, Zhejing Lin. Oxymatrine suppresses oral squamous cell carcinoma progression by suppressing CXC chemokine receptor 4 in an m6A modification decrease dependent manner. Oncology reports. 2022 Oct; 48(4):. doi: 10.3892/or.2022.8392. [PMID: 36004481]
  • Songyao Kang, Tingting Chen, Zhihui Hao, Xiao Yang, Mingfa Wang, Zhifang Zhang, Sijia Hao, Fengting Lang, Hongxia Hao. Oxymatrine Alleviates Gentamicin-Induced Renal Injury in Rats. Molecules (Basel, Switzerland). 2022 Sep; 27(19):. doi: 10.3390/molecules27196209. [PMID: 36234739]
  • Liu Yang, Jingyun Zhang, Xiaoxiao Han, Chenchi Li, Ranyang Liu, Zihua Ma, Bing Han, Rujia Xie, Qin Yang. [Rat serum containing oxymatrine inhibits the proliferation of LX2 human hepatic stellate cells induced by sodium arsenite via blocking PI3K/AKT pathway]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. 2022 Jul; 38(7):598-604. doi: . [PMID: 35786453]
  • Jianqing Peng, Zimin Cai, Qin Wang, Jia Zhou, Jinzhuan Xu, Di Pan, Tingting Chen, Guangqiong Zhang, Ling Tao, Yi Chen, Xiangchun Shen. Carboxymethyl Chitosan Modified Oxymatrine Liposomes for the Alleviation of Emphysema in Mice via Pulmonary Administration. Molecules (Basel, Switzerland). 2022 Jun; 27(11):. doi: 10.3390/molecules27113610. [PMID: 35684546]
  • Bin Li, Yi Hu, Ting Wu, Ying Feng, Cuiping Jiang, Hongzhi Du, Shan Lu. Apigenin-oxymatrine binary co-amorphous mixture: Enhanced solubility, bioavailability, and anti-inflammatory effect. Food chemistry. 2022 Mar; 373(Pt B):131485. doi: 10.1016/j.foodchem.2021.131485. [PMID: 34740050]
  • Jian Guo, Huating Zeng, Xinmeng Shi, Tao Han, Yimin Liu, Yuping Liu, Congyan Liu, Ding Qu, Yan Chen. A CFH peptide-decorated liposomal oxymatrine inactivates cancer-associated fibroblasts of hepatocellular carcinoma through epithelial-mesenchymal transition reversion. Journal of nanobiotechnology. 2022 Mar; 20(1):114. doi: 10.1186/s12951-022-01311-1. [PMID: 35248071]
  • Ming-Liang Zhang, Wei-Xia Li, Xiao-Yan Wang, Ya-Li Wu, Xiao-Fei Chen, Hui Zhang, Liu-Qing Yang, Cheng-Zhao Wu, Shu-Qi Zhang, Yu-Long Chen, Ke-Ran Feng, Bin Wang, Lu Niu, De-Xin Kong, Jin-Fa Tang. Oxymatrine ameliorates experimental autoimmune encephalomyelitis by rebalancing the homeostasis of gut microbiota and reducing blood-brain barrier disruption. Frontiers in cellular and infection microbiology. 2022; 12(?):1095053. doi: 10.3389/fcimb.2022.1095053. [PMID: 36710971]
  • Hai-Qiao Wang, Feng-Hua Chen, Liang Wang, Li-Qun Chi, Guang-Hua Wang. Biopharmaceutical and Pharmacokinetic Activities of Oxymatrine Determined by a Sensitive UHPLC-MS/MS Method. Current pharmaceutical biotechnology. 2022; 23(1):148-157. doi: 10.2174/1389201022666210118160529. [PMID: 33461460]
  • Shengwei Li, Guangqing Feng, Min Zhang, Xing Zhang, Jihong Lu, Chenyahui Feng, Fangshi Zhu. Oxymatrine attenuates TNBS-induced colinutis in rats through TLR9/Myd88/NF-κB signal pathway. Human & experimental toxicology. 2022 Jan; 41(?):9603271221078866. doi: 10.1177/09603271221078866. [PMID: 35290143]
  • Zhe Zhang, Jianhao Pan, Tao Zhu, Nathalie Malewicz, Kaihe Ye, Jianhui Rong, Yong Luo, Yongli Situ, Alexei Verkhratsky, Yong Wang, Jianhao Zhao, Dan Tang, Hong Nie. Oxymatrine screened from Sophora flavescens by cell membrane immobilized chromatography relieves histamine-independent itch. The Journal of pharmacy and pharmacology. 2021 Dec; 73(12):1617-1629. doi: 10.1093/jpp/rgab145. [PMID: 34718677]
  • Xiao-Long Wang, Fei Chen, Hui Shi, Man Zhang, Lin Yan, Xiu-Ying Pei, Xiao-Dong Peng. Oxymatrine inhibits neuroinflammation byRegulating M1/M2 polarization in N9 microglia through the TLR4/NF-κB pathway. International immunopharmacology. 2021 Nov; 100(?):108139. doi: 10.1016/j.intimp.2021.108139. [PMID: 34517275]
  • Jing-Hui Zhan, Pei-Pei Wang, Zhen-Hua Cui, Xiao-Qi Yue, Yan-Li Zhang. [Mechanism of oxymatrine in treatment of collagen-induced arthritis in mice]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2021 Nov; 46(22):5895-5901. doi: 10.19540/j.cnki.cjcmm.20210708.701. [PMID: 34951180]
  • Yuangeng Li, Ping Yu, Wenwen Fu, Lijian Cai, Ying Yu, Zhiqiang Feng, Yaozhen Wang, Fuyuan Zhang, Xiaofeng Yu, Huali Xu, Dayun Sui. Ginseng-Astragalus-oxymatrine injection ameliorates cyclophosphamide-induced immunosuppression in mice and enhances the immune activity of RAW264.7 cells. Journal of ethnopharmacology. 2021 Oct; 279(?):114387. doi: 10.1016/j.jep.2021.114387. [PMID: 34216728]
  • Z Li, D Liang, Y Xiao, Y Dai, F Ai, J Ding, M Shi, Y Xiao, B Guo. [Oxymatrine improves renal fibrosis and inflammation in diabetic rats by modulating CHK1/2 phosphorylation]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. 2021 Oct; 41(10):1519-1526. doi: 10.12122/j.issn.1673-4254.2021.10.10. [PMID: 34755667]
  • Xin Jin, Wan Fu, Jiaxiu Zhou, Niannian Shuai, Yan Yang, Bo Wang. Oxymatrine attenuates oxidized low‑density lipoprotein‑induced HUVEC injury by inhibiting NLRP3 inflammasome‑mediated pyroptosis via the activation of the SIRT1/Nrf2 signaling pathway. International journal of molecular medicine. 2021 Oct; 48(4):. doi: 10.3892/ijmm.2021.5020. [PMID: 34368883]
  • Min Lv, Qianjun Ma, Shaoyong Zhang, Hui Xu. Agrochemical properties evaluation of some imines alkaloids of matrine/oxymatrine. Bioorganic & medicinal chemistry letters. 2021 09; 48(?):128246. doi: 10.1016/j.bmcl.2021.128246. [PMID: 34233221]
  • Chunli Zheng, Yue Xiao, Chuang Chen, Jinglin Zhu, Ruijie Yang, Jiangna Yan, Ruifei Huang, Wei Xiao, Yonghua Wang, Chao Huang. Systems pharmacology: a combination strategy for improving efficacy of PD-1/PD-L1 blockade. Briefings in bioinformatics. 2021 09; 22(5):. doi: 10.1093/bib/bbab130. [PMID: 33876189]
  • Pei-Liang Dong, ZhengQing Li, Cui-Li Teng, Xin Yin, Xian-Kai Cao, Hua Han. Synthesis and evolution of neuroprotective effects of oxymatrine derivatives as anti-Alzheimer's disease agents. Chemical biology & drug design. 2021 07; 98(1):175-181. doi: 10.1111/cbdd.13862. [PMID: 33963669]
  • Bin Li, Yi Hu, Yujie Guo, Renjie Xu, Xiaoping Fang, Xuecheng Xiao, Cuiping Jiang, Shan Lu. Coamorphous System of Florfenicol-Oxymatrine for Improving the Solubility and Dissolution Rate of Florfenicol: Preparation, Characterization and Molecular Dynamics Simulation. Journal of pharmaceutical sciences. 2021 06; 110(6):2544-2554. doi: 10.1016/j.xphs.2021.02.005. [PMID: 33577826]
  • Amany Mohamed Shalaby, Adel Mohamed Aboregela, Mohamed Ali Alabiad, Mona Tayssir Sadek. The Effect of Induced Diabetes Mellitus on the Cerebellar Cortex of Adult Male Rat and the Possible Protective Role of Oxymatrine: A Histological, Immunohistochemical and Biochemical Study. Ultrastructural pathology. 2021 May; 45(3):182-196. doi: 10.1080/01913123.2021.1926610. [PMID: 34000959]
  • Z Y Wu, X F Meng, Y S Jiao, B L Guo, X H Sui, S J Ma, W F Chen, R P Singh. Bradyrhizobium arachidis mediated enhancement of (oxy)matrine content in the medicinal legume Sophora flavescens. Letters in applied microbiology. 2021 May; 72(5):570-577. doi: 10.1111/lam.13453. [PMID: 33474743]
  • Guangfei Wei, Yongzhong Chen, Xiaotong Guo, Jianhe Wei, Linlin Dong, Shilin Chen. Biosyntheses characterization of alkaloids and flavonoids in Sophora flavescens by combining metabolome and transcriptome. Scientific reports. 2021 04; 11(1):7388. doi: 10.1038/s41598-021-86970-0. [PMID: 33795823]
  • Yayun Wu, Lijuan Liu, Ya Zhao, Ruizhi Zhao. Polysaccharides of vinegar-baked radix bupleuri promote the hepatic targeting effect of oxymatrine by regulating the protein expression of HNF4α, Mrp2, and OCT1. Journal of ethnopharmacology. 2021 Mar; 267(?):113471. doi: 10.1016/j.jep.2020.113471. [PMID: 33075440]
  • Qing Zhao, Mengjuan Wei, Shaobo Zhang, Zhenlin Huang, Bin Lu, Lili Ji. The water extract of Sophorae tonkinensis Radix et Rhizoma alleviates non-alcoholic fatty liver disease and its mechanism. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2020 Oct; 77(?):153270. doi: 10.1016/j.phymed.2020.153270. [PMID: 32702591]
  • He Zhang, Liying Yang, Yichao Wang, Wenli Huang, Yang Li, Shuchun Chen, Guangyao Song, Luping Ren. Oxymatrine alleviated hepatic lipid metabolism via regulating miR-182 in non-alcoholic fatty liver disease. Life sciences. 2020 Sep; 257(?):118090. doi: 10.1016/j.lfs.2020.118090. [PMID: 32679144]
  • Tao Zhu, Dan Zhou, Zhe Zhang, Lina Long, Yujuan Liu, Qinghong Fan, Feifan Chen, Xueke Zhang, Yan Wu, Hekun Zeng, Alexei Verkhratsky, Jianhao Zhao, Hong Nie. Analgesic and antipruritic effects of oxymatrine sustained-release microgel cream in a mouse model of inflammatory itch and pain. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2020 Jan; 141(?):105110. doi: 10.1016/j.ejps.2019.105110. [PMID: 31654757]
  • Yongpan Huang, Xinliang Li, Xi Zhang, Jiayu Tang. Oxymatrine Ameliorates Memory Impairment in Diabetic Rats by Regulating Oxidative Stress and Apoptosis: Involvement of NOX2/NOX4. Oxidative medicine and cellular longevity. 2020; 2020(?):3912173. doi: 10.1155/2020/3912173. [PMID: 33273999]
  • Hui Xu, Ming Xu, Zhiqiang Sun, Shaochen Li. Preparation of Matrinic/Oxymatrinic Amide Derivatives as Insecticidal/Acaricidal Agents and Study on the Mechanisms of Action against Tetranychus cinnabarinus. Journal of agricultural and food chemistry. 2019 Nov; 67(44):12182-12190. doi: 10.1021/acs.jafc.9b05092. [PMID: 31609606]
  • H-J Shi, H Zhou, A-L Ma, L Wang, Q Gao, N Zhang, H-B Song, K-P Bo, W Ma. Oxymatrine therapy inhibited epidermal cell proliferation and apoptosis in severe plaque psoriasis. The British journal of dermatology. 2019 11; 181(5):1028-1037. doi: 10.1111/bjd.17852. [PMID: 30822359]
  • Yun Chen, Ziyou Qi, Baojun Qiao, Zhanyun Lv, Yanlei Hao, Hongfang Li. Oxymatrine can attenuate pathological deficits of Alzheimer's disease mice through regulation of neuroinflammation. Journal of neuroimmunology. 2019 09; 334(?):576978. doi: 10.1016/j.jneuroim.2019.576978. [PMID: 31177033]
  • Lan-Lan Lou, Fu-Qiang Ni, Lin Chen, Sharpkate Shaker, Wei Li, Rong Wang, Gui-Hua Tang, Sheng Yin. Germacrane Sesquiterpenoids as a New Type of Anticardiac Fibrosis Agent Targeting Transforming Growth Factor β Type I Receptor. Journal of medicinal chemistry. 2019 09; 62(17):7961-7975. doi: 10.1021/acs.jmedchem.9b00708. [PMID: 31408333]
  • Peiliang Dong, Xiaomeng Ji, Wei Han, Hua Han. Oxymatrine exhibits anti-neuroinflammatory effects on Aβ1-42-induced primary microglia cells by inhibiting NF-κB and MAPK signaling pathways. International immunopharmacology. 2019 Sep; 74(?):105686. doi: 10.1016/j.intimp.2019.105686. [PMID: 31207405]
  • Yifan Wang, Zhexing Shou, Heng Fan, Meng Xu, Qianyun Chen, Qing Tang, Xingxing Liu, Hui Wu, Man Zhang, Ting Yu, Shuangjiao Deng, Yujin Liu. Protective effects of oxymatrine against DSS-induced acute intestinal inflammation in mice via blocking the RhoA/ROCK signaling pathway. Bioscience reports. 2019 07; 39(7):. doi: 10.1042/bsr20182297. [PMID: 31262973]
  • Daniel Júnior de Andrade, Edenilson Batista Ribeiro, Matheus Rovere de Morais, Odimar Zanuzo Zanardi. Bioactivity of an oxymatrine-based commercial formulation against Brevipalpus yothersi Baker and its effects on predatory mites in citrus groves. Ecotoxicology and environmental safety. 2019 Jul; 176(?):339-345. doi: 10.1016/j.ecoenv.2019.03.118. [PMID: 30953999]
  • Yu Yang, Shiping Chen, Ling Tao, Shiquan Gan, Hong Luo, Yini Xu, Xiangchun Shen. Inhibitory Effects of Oxymatrine on Transdifferentiation of Neonatal Rat Cardiac Fibroblasts to Myofibroblasts Induced by Aldosterone via Keap1/Nrf2 Signaling Pathways In Vitro. Medical science monitor : international medical journal of experimental and clinical research. 2019 Jul; 25(?):5375-5388. doi: 10.12659/msm.915542. [PMID: 31325292]
  • Li-Ying Song, Yu-Tao Ma, Wei-Jin Fang, Yang He, Jia-Li Wu, Shan-Ru Zuo, Zhen-Zhen Deng, Sheng-Feng Wang, Shi-Kun Liu. Inhibitory effects of oxymatrine on hepatic stellate cells activation through TGF-β/miR-195/Smad signaling pathway. BMC complementary and alternative medicine. 2019 Jun; 19(1):138. doi: 10.1186/s12906-019-2560-2. [PMID: 31221141]
  • Ji Sun Kim, Seung Jae Shin, Jung Nam Kim, Min Ji Kwon, Eun Yeong Lim, Yun Tai Kim, Hyungwoo Kim, Byung Joo Kim. Radix Sophorae Flavescentis inhibits proliferation and induces apoptosis of AGS human gastric cancer cells. Molecular medicine reports. 2019 Mar; 19(3):1911-1918. doi: 10.3892/mmr.2018.9776. [PMID: 30569168]
  • Peiliang Dong, Xiaomeng Ji, Wei Han, Hua Han. Oxymatrine attenuates amyloid beta 42 (Aβ1-42)-induced neurotoxicity in primary neuronal cells and memory impairment in rats. Canadian journal of physiology and pharmacology. 2019 Feb; 97(2):99-106. doi: 10.1139/cjpp-2018-0299. [PMID: 30485133]
  • Jian Cui, Zhipeng Qu, Yuka Harata-Lee, Thazin Nwe Aung, Hanyuan Shen, Wei Wang, David L Adelson. Cell cycle, energy metabolism and DNA repair pathways in cancer cells are suppressed by Compound Kushen Injection. BMC cancer. 2019 Jan; 19(1):103. doi: 10.1186/s12885-018-5230-8. [PMID: 30678652]
  • Ruiying Wang, Min Wang, Shan Wang, Ke Yang, Ping Zhou, Xueheng Xie, Qi Cheng, Jingxue Ye, Guibo Sun, Xiaobo Sun. An integrated characterization of contractile, electrophysiological, and structural cardiotoxicity of Sophora tonkinensis Gapnep. in human pluripotent stem cell-derived cardiomyocytes. Stem cell research & therapy. 2019 01; 10(1):20. doi: 10.1186/s13287-018-1126-4. [PMID: 30635051]
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