Oxymatrine (BioDeep_00000002601)

 

Secondary id: BioDeep_00000893711

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


1H,5H,10H-Dipyrido(2,1-f:3,2,1-ij)(1,6)naphthyridin-10-one, dodecahydro-, 4-oxide, (4R,7aS,13aR,13bR,13cS)-

化学式: C15H24N2O2 (264.1838)
中文名称: 氧化槐定碱, 苦参素, 氧化苦参碱
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 51.15%

分子结构信息

SMILES: C1CC2C3CCC[N+]4(C3C(CCC4)CN2C(=O)C1)[O-]
InChI: InChI=1S/C15H24N2O2/c18-14-7-1-6-13-12-5-3-9-17(19)8-2-4-11(15(12)17)10-16(13)14/h11-13,15H,1-10H2/t11-,12+,13+,15-,17+/m0/s1

描述信息

Ammothamnine is an alkaloid and a tertiary amine oxide.
Oxymatrine is a natural product found in Sophora pachycarpa, Sophora chrysophylla, and other organisms with data available.
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents
Origin: Plant; SubCategory_DNP: Alkaloids derived from lysine, Quinolizidine alkaloids, Sophora alkaloid
Oxymatrine is under investigation in clinical trial NCT02202473 (Oxymatrine Plus Lamivudine Combination Therapy Versus Lamivudine Monotherapy for Chronic Hepatitis B Infected Subjects).
Matrine oxide is a natural product found in Daphniphyllum oldhamii, Sophora viciifolia, and other organisms with data available.
Oxymatrine, an alkaloid from Sophora flavescens Alt. with anti-inflammatory, antifibrosis, and antitumor effects, inhibits the iNOS expression and TGF-β/Smad pathway. Oxymatrine inhibits bocavirus minute virus of canines (MVC) replication, reduces viral gene expression and decreases apoptosis induced by viral infection.
Oxymatrine, an alkaloid from Sophora flavescens Alt. with anti-inflammatory, antifibrosis, and antitumor effects, inhibits the iNOS expression and TGF-β/Smad pathway. Oxymatrine inhibits bocavirus minute virus of canines (MVC) replication, reduces viral gene expression and decreases apoptosis induced by viral infection.
Oxysophoridine (Sophoridine N-oxide) is a bioactive alkaloid extracted from the Sophora alopecuroides Linn. Oxysophoridine (Sophoridine N-oxide) shows anti inflammatory, anti oxidative stress and anti apoptosis effects[1][2].
Oxysophoridine (Sophoridine N-oxide) is a bioactive alkaloid extracted from the Sophora alopecuroides Linn. Oxysophoridine (Sophoridine N-oxide) shows anti inflammatory, anti oxidative stress and anti apoptosis effects[1][2].

同义名列表

29 个代谢物同义名

1H,5H,10H-Dipyrido[2,1-f:3,2,1-ij][1,6]naphthyridin-10-one,dodecahydro-, 4-oxide, (7aR,13aR,13bR,13cS)-; (7aS,13aR,13bR,13cS)dodecahydro-1H,5H,10H-dipyrido[2,1-f:3,2,1-ij][1,6]naphthyridin-10-one 4-oxide; rel-(41S,7aS,13aR,13bR)-10-Oxohexadecahydrodipyrido[2,1-f:3,2,1-ij][1,6]naphthyridine 4-oxide; rel-(41S,7aS,13aR,13bR)-10-Oxohexadecahydrodipyrido[2,1-f:3,2,1-ij][1,6]naphthyridine4-oxide; (1R,2R,9S,13R,17S)-13-Oxido-7-aza-13-azoniatetracyclo[7.7.1.02,7.013,17]heptadecan-6-one; (1R,2R,9S,17S)-6-oxo-7,13-diazatetracyclo[7.7.1.0?,?.0??,??]heptadecan-13-ium-13-olate; (1R,2R,9S,17S)-13-oxido-7-aza-13-azoniatetracyclo[7.7.1.02,7.013,17]heptadecan-6-one; Oxymatrine (Matrine N-oxide); XVPBINOPNYFXID-LHDUFFHYSA-N; Sophoridine N-oxide; Matrine 1beta-oxide; (+)-Matrine N-oxide; Matrine N-oxide; Pachycarpidine; (+)-oxymatrine; Oxysophoridine; Oxymatrine,(S); Matrine oxide; Ammothamnine; Oxymatrine; 1H,5H,10H-Dipyrido(2,1-f:3,2,1-ij)(1,6)naphthyridin-10-one, dodecahydro-, 4-oxide, (4R,7aS,13aR,13bR,13cS)-; (4R,7AS,13AR,13BR,13CS)-DODECAHYDRO-1H,5H,10H-DIPYRIDO(2,1-F:3,2,1-IJ)(1,6)NAPHTHYRIDIN-10-ONE 4-OXIDE; (7AS,13AR,13BR,13CS)-DODECAHYDRO-1H,5H,10H-DIPYRIDO(2,1-F:3,2,1-IJ)(1,6)NAPHTHYRIDIN-10-ONE 4-OXIDE; Matridin-15-one, 1-oxide, (1-beta)-; OXYMATRINE [WHO-DD]; Matrine, 1-oxide; UNII-85U4C366QS; 85U4C366QS; Ammothamnine



数据库引用编号

31 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

53 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 AKT1, BCL2, CASP3, CTNNB1, MTOR, MYD88, PTGS2, STAT3, TGFB1, TLR4, TP53, VEGFA
Peripheral membrane protein 2 MTOR, PTGS2
Endosome membrane 2 MYD88, TLR4
Endoplasmic reticulum membrane 3 BCL2, MTOR, PTGS2
Nucleus 11 AKT1, BCL2, CASP3, CTNNB1, MPO, MTOR, MYD88, STAT3, TGFB1, TP53, VEGFA
cytosol 9 AKT1, BCL2, CASP3, CTNNB1, GPT, MTOR, MYD88, STAT3, TP53
dendrite 1 MTOR
phagocytic vesicle 1 MTOR
centrosome 2 CTNNB1, TP53
nucleoplasm 7 AKT1, CASP3, CTNNB1, MPO, MTOR, STAT3, TP53
RNA polymerase II transcription regulator complex 1 STAT3
Cell membrane 3 AKT1, CTNNB1, TLR4
Cytoplasmic side 1 MTOR
lamellipodium 2 AKT1, CTNNB1
Golgi apparatus membrane 1 MTOR
Synapse 1 CTNNB1
cell cortex 2 AKT1, CTNNB1
cell junction 1 CTNNB1
cell surface 4 MYD88, TGFB1, TLR4, VEGFA
glutamatergic synapse 3 AKT1, CASP3, CTNNB1
Golgi apparatus 1 VEGFA
Golgi membrane 1 MTOR
lysosomal membrane 1 MTOR
neuronal cell body 2 CASP3, TGFB1
postsynapse 1 AKT1
presynaptic membrane 1 CTNNB1
Lysosome 2 MPO, MTOR
plasma membrane 7 AKT1, CTNNB1, IFNLR1, MYD88, STAT3, TGFB1, TLR4
Membrane 8 AKT1, BCL2, CTNNB1, IFNLR1, MTOR, TLR4, TP53, VEGFA
axon 1 TGFB1
basolateral plasma membrane 1 CTNNB1
caveola 1 PTGS2
extracellular exosome 3 CTNNB1, GPT, MPO
Lysosome membrane 1 MTOR
endoplasmic reticulum 4 BCL2, PTGS2, TP53, VEGFA
extracellular space 8 CXCL8, IL10, IL2, IL4, IL6, MPO, TGFB1, VEGFA
perinuclear region of cytoplasm 2 CTNNB1, TLR4
Schaffer collateral - CA1 synapse 1 CTNNB1
adherens junction 2 CTNNB1, VEGFA
apicolateral plasma membrane 1 CTNNB1
bicellular tight junction 1 CTNNB1
mitochondrion 2 BCL2, TP53
protein-containing complex 6 AKT1, BCL2, CTNNB1, MYD88, PTGS2, TP53
intracellular membrane-bounded organelle 1 MPO
Microsome membrane 2 MTOR, PTGS2
postsynaptic density 1 CASP3
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 2 IFNLR1, TLR4
Secreted 7 CXCL8, IL10, IL2, IL4, IL6, TGFB1, VEGFA
extracellular region 8 CXCL8, IL10, IL2, IL4, IL6, MPO, TGFB1, VEGFA
Mitochondrion outer membrane 2 BCL2, MTOR
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, MTOR
Mitochondrion matrix 1 TP53
mitochondrial matrix 1 TP53
transcription regulator complex 3 CTNNB1, STAT3, TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 1 TLR4
Secreted, extracellular space, extracellular matrix 2 TGFB1, VEGFA
Z disc 1 CTNNB1
beta-catenin destruction complex 1 CTNNB1
microtubule cytoskeleton 1 AKT1
nucleolus 1 TP53
Wnt signalosome 1 CTNNB1
Early endosome 1 TLR4
apical part of cell 1 CTNNB1
cell-cell junction 2 AKT1, CTNNB1
vesicle 1 AKT1
postsynaptic membrane 1 CTNNB1
pore complex 1 BCL2
Cytoplasm, cytoskeleton 2 CTNNB1, TP53
focal adhesion 1 CTNNB1
spindle 1 AKT1
Cell junction, adherens junction 1 CTNNB1
flotillin complex 1 CTNNB1
extracellular matrix 2 TGFB1, VEGFA
Nucleus, PML body 2 MTOR, TP53
PML body 2 MTOR, TP53
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 1 TGFB1
secretory granule 3 MPO, TGFB1, VEGFA
fascia adherens 1 CTNNB1
lateral plasma membrane 1 CTNNB1
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Cell projection, ruffle 1 TLR4
ruffle 1 TLR4
receptor complex 1 TLR4
neuron projection 1 PTGS2
ciliary basal body 1 AKT1
chromatin 2 STAT3, TP53
phagocytic cup 1 TLR4
cell periphery 1 CTNNB1
Cytoplasm, cytoskeleton, cilium basal body 1 CTNNB1
spindle pole 1 CTNNB1
blood microparticle 1 TGFB1
postsynaptic density, intracellular component 1 CTNNB1
microvillus membrane 1 CTNNB1
site of double-strand break 1 TP53
nuclear envelope 1 MTOR
Endomembrane system 2 CTNNB1, MTOR
euchromatin 1 CTNNB1
germ cell nucleus 1 TP53
replication fork 1 TP53
myelin sheath 1 BCL2
azurophil granule 1 MPO
lipopolysaccharide receptor complex 1 TLR4
Golgi lumen 1 TGFB1
endoplasmic reticulum lumen 2 IL6, PTGS2
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
platelet alpha granule lumen 2 TGFB1, VEGFA
beta-catenin-TCF complex 1 CTNNB1
azurophil granule lumen 1 MPO
presynaptic active zone cytoplasmic component 1 CTNNB1
phagocytic vesicle lumen 1 MPO
[Isoform 1]: Nucleus 1 TP53
extrinsic component of cytoplasmic side of plasma membrane 1 MYD88
protein-DNA complex 1 CTNNB1
death-inducing signaling complex 1 CASP3
Cytoplasmic vesicle, phagosome 1 MTOR
extrinsic component of plasma membrane 1 MYD88
catenin complex 1 CTNNB1
[Latency-associated peptide]: Secreted, extracellular space, extracellular matrix 1 TGFB1
[Transforming growth factor beta-1]: Secreted 1 TGFB1
interleukin-6 receptor complex 1 IL6
BAD-BCL-2 complex 1 BCL2
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
beta-catenin-TCF7L2 complex 1 CTNNB1
beta-catenin-ICAT complex 1 CTNNB1
Scrib-APC-beta-catenin complex 1 CTNNB1
interleukin-28 receptor complex 1 IFNLR1


文献列表

  • Yan Zhi, Xinping Zhao, Zhenyi Liu, Guoyu Shen, Taiming Zhang, Tao Zhang, Ge Hu. Oxymatrine Modulation of TLR3 Signaling: A Dual-Action Mechanism for H9N2 Avian Influenza Virus Defense and Immune Regulation. Molecules (Basel, Switzerland). 2024 Apr; 29(9):. doi: 10.3390/molecules29091945. [PMID: 38731436]
  • Jinying Lu, Jiang Bian, Yutong Wang, Yan Zhao, Xinmin Zhao, Gao Wang, Jing Yang. Oxymatrine protects articular chondrocytes from IL-1β-induced damage through autophagy activation via AKT/mTOR signaling pathway inhibition. Journal of orthopaedic surgery and research. 2024 Mar; 19(1):178. doi: 10.1186/s13018-024-04667-2. [PMID: 38468339]
  • Ashmita Das, Onkar Kashyap, Devi P Pandey, Surendra H Bodakhe. Oxymatrine impedes the progression of endotoxin-induced glaucoma via redox system modulations. Journal of biochemical and molecular toxicology. 2024 Jan; 38(1):e23631. doi: 10.1002/jbt.23631. [PMID: 38229309]
  • Chen He, Wenjing Wang, Guoli Wei, Yuqing Wang, Yingjie Wei, Jing Wang, Zhenhai Zhang. Sodium alginate combined with oxymatrine ameliorates CCl4-induced chemical hepatic fibrosis in mice. International immunopharmacology. 2023 Nov; 125(Pt A):111144. doi: 10.1016/j.intimp.2023.111144. [PMID: 37922569]
  • Benjamin Christian Fischer, Yemurai Musengi, Jeannette König, Benjamin Sachse, Stefanie Hessel-Pras, Bernd Schäfer, Carsten Kneuer, Kristin Herrmann. Matrine and Oxymatrine: Evaluating the gene mutation potential using in silico tools and the bacterial reverse mutation assay (Ames test). Mutagenesis. 2023 Oct; ?(?):. doi: 10.1093/mutage/gead032. [PMID: 37877816]
  • Hong Wang, Liangyin Wei, Dengxuan Mao, Xiaoyu Che, Xietao Ye, Yuping Liu, Yan Chen. Combination of oxymatrine (Om) and astragaloside IV (As) enhances the infiltration and function of TILs in triple-negative breast cancer (TNBC). International immunopharmacology. 2023 Oct; 125(Pt A):111026. doi: 10.1016/j.intimp.2023.111026. [PMID: 37866315]
  • Gan Cao, Zhuhan Mao, Tengyao Niu, Peipei Wang, Xiaoqi Yue, Xuemei Wang, Ailing Ma, Yanli Zhang. Oxymatrine ameliorates rheumatoid arthritis by regulation of Tfr/Tfh cells balance via TLR9-MyD88-STAT3 signaling pathway. Journal of the science of food and agriculture. 2023 May; ?(?):. doi: 10.1002/jsfa.12674. [PMID: 37128150]
  • Li Liang, Weiliang Sun, Xiaoxuan Wei, Li Wang, Huaqiang Ruan, Junchuan Zhang, Suyan Li, Bi Zhao, Mengshi Li, Zhengwen Cai, Jie'an Huang. Oxymatrine suppresses colorectal cancer progression by inhibiting NLRP3 inflammasome activation through mitophagy induction in vitro and in vivo. Phytotherapy research : PTR. 2023 Mar; ?(?):. doi: 10.1002/ptr.7808. [PMID: 36974424]
  • Xiao-Bing Lan, Yuan-Shu Ni, Ning Liu, Wei Wei, Yue Liu, Jia-Mei Yang, Lin Ma, Ru Bai, Jian Zhang, Jian-Qiang Yu. Neuroprotective effects of oxymatrine on hypoxic-ischemic brain damage in neonatal rats by activating the Wnt/β-catenin pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Mar; 159(?):114266. doi: 10.1016/j.biopha.2023.114266. [PMID: 36652736]
  • Luping Ren, Xuehua Liu, Xitong Huang, He Zhang, Wenjie Fei, Xian Yu, Zhijuan Hu, Yunfeng Zhen, Shuchun Chen. Oxymatrine relieves high-fructose/fat-induced obesity via reprogramming the activity of lipid metabolism-related enhancer. Frontiers in endocrinology. 2023; 14(?):1145575. doi: 10.3389/fendo.2023.1145575. [PMID: 37600712]
  • Jing Li, Jianhao Liang, Meiqin Zeng, Kaijian Sun, Yunhao Luo, Huaping Zheng, Feng Li, Wen Yuan, Hongwei Zhou, Junshan Liu, Haitao Sun. Oxymatrine ameliorates white matter injury by modulating gut microbiota after intracerebral hemorrhage in mice. CNS neuroscience & therapeutics. 2022 Dec; ?(?):. doi: 10.1111/cns.14066. [PMID: 36550632]
  • Renhui Luo, Lili Xie, Yingmei Lin, Jun Shao, Zhejing Lin. Oxymatrine suppresses oral squamous cell carcinoma progression by suppressing CXC chemokine receptor 4 in an m6A modification decrease dependent manner. Oncology reports. 2022 Oct; 48(4):. doi: 10.3892/or.2022.8392. [PMID: 36004481]
  • Songyao Kang, Tingting Chen, Zhihui Hao, Xiao Yang, Mingfa Wang, Zhifang Zhang, Sijia Hao, Fengting Lang, Hongxia Hao. Oxymatrine Alleviates Gentamicin-Induced Renal Injury in Rats. Molecules (Basel, Switzerland). 2022 Sep; 27(19):. doi: 10.3390/molecules27196209. [PMID: 36234739]
  • Liu Yang, Jingyun Zhang, Xiaoxiao Han, Chenchi Li, Ranyang Liu, Zihua Ma, Bing Han, Rujia Xie, Qin Yang. [Rat serum containing oxymatrine inhibits the proliferation of LX2 human hepatic stellate cells induced by sodium arsenite via blocking PI3K/AKT pathway]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. 2022 Jul; 38(7):598-604. doi: . [PMID: 35786453]
  • Jianqing Peng, Zimin Cai, Qin Wang, Jia Zhou, Jinzhuan Xu, Di Pan, Tingting Chen, Guangqiong Zhang, Ling Tao, Yi Chen, Xiangchun Shen. Carboxymethyl Chitosan Modified Oxymatrine Liposomes for the Alleviation of Emphysema in Mice via Pulmonary Administration. Molecules (Basel, Switzerland). 2022 Jun; 27(11):. doi: 10.3390/molecules27113610. [PMID: 35684546]
  • Bin Li, Yi Hu, Ting Wu, Ying Feng, Cuiping Jiang, Hongzhi Du, Shan Lu. Apigenin-oxymatrine binary co-amorphous mixture: Enhanced solubility, bioavailability, and anti-inflammatory effect. Food chemistry. 2022 Mar; 373(Pt B):131485. doi: 10.1016/j.foodchem.2021.131485. [PMID: 34740050]
  • Jian Guo, Huating Zeng, Xinmeng Shi, Tao Han, Yimin Liu, Yuping Liu, Congyan Liu, Ding Qu, Yan Chen. A CFH peptide-decorated liposomal oxymatrine inactivates cancer-associated fibroblasts of hepatocellular carcinoma through epithelial-mesenchymal transition reversion. Journal of nanobiotechnology. 2022 Mar; 20(1):114. doi: 10.1186/s12951-022-01311-1. [PMID: 35248071]
  • Ming-Liang Zhang, Wei-Xia Li, Xiao-Yan Wang, Ya-Li Wu, Xiao-Fei Chen, Hui Zhang, Liu-Qing Yang, Cheng-Zhao Wu, Shu-Qi Zhang, Yu-Long Chen, Ke-Ran Feng, Bin Wang, Lu Niu, De-Xin Kong, Jin-Fa Tang. Oxymatrine ameliorates experimental autoimmune encephalomyelitis by rebalancing the homeostasis of gut microbiota and reducing blood-brain barrier disruption. Frontiers in cellular and infection microbiology. 2022; 12(?):1095053. doi: 10.3389/fcimb.2022.1095053. [PMID: 36710971]
  • Hai-Qiao Wang, Feng-Hua Chen, Liang Wang, Li-Qun Chi, Guang-Hua Wang. Biopharmaceutical and Pharmacokinetic Activities of Oxymatrine Determined by a Sensitive UHPLC-MS/MS Method. Current pharmaceutical biotechnology. 2022; 23(1):148-157. doi: 10.2174/1389201022666210118160529. [PMID: 33461460]
  • Shengwei Li, Guangqing Feng, Min Zhang, Xing Zhang, Jihong Lu, Chenyahui Feng, Fangshi Zhu. Oxymatrine attenuates TNBS-induced colinutis in rats through TLR9/Myd88/NF-κB signal pathway. Human & experimental toxicology. 2022 Jan; 41(?):9603271221078866. doi: 10.1177/09603271221078866. [PMID: 35290143]
  • Zhe Zhang, Jianhao Pan, Tao Zhu, Nathalie Malewicz, Kaihe Ye, Jianhui Rong, Yong Luo, Yongli Situ, Alexei Verkhratsky, Yong Wang, Jianhao Zhao, Dan Tang, Hong Nie. Oxymatrine screened from Sophora flavescens by cell membrane immobilized chromatography relieves histamine-independent itch. The Journal of pharmacy and pharmacology. 2021 Dec; 73(12):1617-1629. doi: 10.1093/jpp/rgab145. [PMID: 34718677]
  • Xiao-Long Wang, Fei Chen, Hui Shi, Man Zhang, Lin Yan, Xiu-Ying Pei, Xiao-Dong Peng. Oxymatrine inhibits neuroinflammation byRegulating M1/M2 polarization in N9 microglia through the TLR4/NF-κB pathway. International immunopharmacology. 2021 Nov; 100(?):108139. doi: 10.1016/j.intimp.2021.108139. [PMID: 34517275]
  • Jing-Hui Zhan, Pei-Pei Wang, Zhen-Hua Cui, Xiao-Qi Yue, Yan-Li Zhang. [Mechanism of oxymatrine in treatment of collagen-induced arthritis in mice]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2021 Nov; 46(22):5895-5901. doi: 10.19540/j.cnki.cjcmm.20210708.701. [PMID: 34951180]
  • Yuangeng Li, Ping Yu, Wenwen Fu, Lijian Cai, Ying Yu, Zhiqiang Feng, Yaozhen Wang, Fuyuan Zhang, Xiaofeng Yu, Huali Xu, Dayun Sui. Ginseng-Astragalus-oxymatrine injection ameliorates cyclophosphamide-induced immunosuppression in mice and enhances the immune activity of RAW264.7 cells. Journal of ethnopharmacology. 2021 Oct; 279(?):114387. doi: 10.1016/j.jep.2021.114387. [PMID: 34216728]
  • Z Li, D Liang, Y Xiao, Y Dai, F Ai, J Ding, M Shi, Y Xiao, B Guo. [Oxymatrine improves renal fibrosis and inflammation in diabetic rats by modulating CHK1/2 phosphorylation]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. 2021 Oct; 41(10):1519-1526. doi: 10.12122/j.issn.1673-4254.2021.10.10. [PMID: 34755667]
  • Xin Jin, Wan Fu, Jiaxiu Zhou, Niannian Shuai, Yan Yang, Bo Wang. Oxymatrine attenuates oxidized low‑density lipoprotein‑induced HUVEC injury by inhibiting NLRP3 inflammasome‑mediated pyroptosis via the activation of the SIRT1/Nrf2 signaling pathway. International journal of molecular medicine. 2021 Oct; 48(4):. doi: 10.3892/ijmm.2021.5020. [PMID: 34368883]
  • Min Lv, Qianjun Ma, Shaoyong Zhang, Hui Xu. Agrochemical properties evaluation of some imines alkaloids of matrine/oxymatrine. Bioorganic & medicinal chemistry letters. 2021 09; 48(?):128246. doi: 10.1016/j.bmcl.2021.128246. [PMID: 34233221]
  • Chunli Zheng, Yue Xiao, Chuang Chen, Jinglin Zhu, Ruijie Yang, Jiangna Yan, Ruifei Huang, Wei Xiao, Yonghua Wang, Chao Huang. Systems pharmacology: a combination strategy for improving efficacy of PD-1/PD-L1 blockade. Briefings in bioinformatics. 2021 09; 22(5):. doi: 10.1093/bib/bbab130. [PMID: 33876189]
  • Pei-Liang Dong, ZhengQing Li, Cui-Li Teng, Xin Yin, Xian-Kai Cao, Hua Han. Synthesis and evolution of neuroprotective effects of oxymatrine derivatives as anti-Alzheimer's disease agents. Chemical biology & drug design. 2021 07; 98(1):175-181. doi: 10.1111/cbdd.13862. [PMID: 33963669]
  • Bin Li, Yi Hu, Yujie Guo, Renjie Xu, Xiaoping Fang, Xuecheng Xiao, Cuiping Jiang, Shan Lu. Coamorphous System of Florfenicol-Oxymatrine for Improving the Solubility and Dissolution Rate of Florfenicol: Preparation, Characterization and Molecular Dynamics Simulation. Journal of pharmaceutical sciences. 2021 06; 110(6):2544-2554. doi: 10.1016/j.xphs.2021.02.005. [PMID: 33577826]
  • Amany Mohamed Shalaby, Adel Mohamed Aboregela, Mohamed Ali Alabiad, Mona Tayssir Sadek. The Effect of Induced Diabetes Mellitus on the Cerebellar Cortex of Adult Male Rat and the Possible Protective Role of Oxymatrine: A Histological, Immunohistochemical and Biochemical Study. Ultrastructural pathology. 2021 May; 45(3):182-196. doi: 10.1080/01913123.2021.1926610. [PMID: 34000959]
  • Z Y Wu, X F Meng, Y S Jiao, B L Guo, X H Sui, S J Ma, W F Chen, R P Singh. Bradyrhizobium arachidis mediated enhancement of (oxy)matrine content in the medicinal legume Sophora flavescens. Letters in applied microbiology. 2021 May; 72(5):570-577. doi: 10.1111/lam.13453. [PMID: 33474743]
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  • Yayun Wu, Lijuan Liu, Ya Zhao, Ruizhi Zhao. Polysaccharides of vinegar-baked radix bupleuri promote the hepatic targeting effect of oxymatrine by regulating the protein expression of HNF4α, Mrp2, and OCT1. Journal of ethnopharmacology. 2021 Mar; 267(?):113471. doi: 10.1016/j.jep.2020.113471. [PMID: 33075440]
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