Matrine 1beta-oxide (BioDeep_00000893711)

Main id: BioDeep_00000002601

 

human metabolite PANOMIX_OTCML-2023 blood metabolite natural product


代谢物信息卡片


6-oxo-7,13-diazatetracyclo[7.7.1.0²,⁷.0¹³,¹⁷]heptadecan-13-ium-13-olate

化学式: C15H24N2O2 (264.1838)
中文名称: 氧化槐定碱
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CC2C3CCC[N+]4(C3C(CCC4)CN2C(=O)C1)[O-]
InChI: InChI=1S/C15H24N2O2/c18-14-7-1-6-13-12-5-3-9-17(19)8-2-4-11(15(12)17)10-16(13)14/h11-13,15H,1-10H2

描述信息

Oxysophoridine (Sophoridine N-oxide) is a bioactive alkaloid extracted from the Sophora alopecuroides Linn. Oxysophoridine (Sophoridine N-oxide) shows anti inflammatory, anti oxidative stress and anti apoptosis effects[1][2].
Oxysophoridine (Sophoridine N-oxide) is a bioactive alkaloid extracted from the Sophora alopecuroides Linn. Oxysophoridine (Sophoridine N-oxide) shows anti inflammatory, anti oxidative stress and anti apoptosis effects[1][2].

同义名列表

5 个代谢物同义名

6-oxo-7,13-diazatetracyclo[7.7.1.0²,⁷.0¹³,¹⁷]heptadecan-13-ium-13-olate; Matrine 1beta-oxide; Oxysophoridine; Oxymatrine; Sophoridine N-oxide



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

12 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Liu Yang, Jingyun Zhang, Xiaoxiao Han, Chenchi Li, Ranyang Liu, Zihua Ma, Bing Han, Rujia Xie, Qin Yang. [Rat serum containing oxymatrine inhibits the proliferation of LX2 human hepatic stellate cells induced by sodium arsenite via blocking PI3K/AKT pathway]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. 2022 Jul; 38(7):598-604. doi: . [PMID: 35786453]
  • Hai-Qiao Wang, Feng-Hua Chen, Liang Wang, Li-Qun Chi, Guang-Hua Wang. Biopharmaceutical and Pharmacokinetic Activities of Oxymatrine Determined by a Sensitive UHPLC-MS/MS Method. Current pharmaceutical biotechnology. 2022; 23(1):148-157. doi: 10.2174/1389201022666210118160529. [PMID: 33461460]
  • Jing-Hui Zhan, Pei-Pei Wang, Zhen-Hua Cui, Xiao-Qi Yue, Yan-Li Zhang. [Mechanism of oxymatrine in treatment of collagen-induced arthritis in mice]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2021 Nov; 46(22):5895-5901. doi: 10.19540/j.cnki.cjcmm.20210708.701. [PMID: 34951180]
  • Z Li, D Liang, Y Xiao, Y Dai, F Ai, J Ding, M Shi, Y Xiao, B Guo. [Oxymatrine improves renal fibrosis and inflammation in diabetic rats by modulating CHK1/2 phosphorylation]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. 2021 Oct; 41(10):1519-1526. doi: 10.12122/j.issn.1673-4254.2021.10.10. [PMID: 34755667]
  • Yayun Wu, Lijuan Liu, Ya Zhao, Ruizhi Zhao. Polysaccharides of vinegar-baked radix bupleuri promote the hepatic targeting effect of oxymatrine by regulating the protein expression of HNF4α, Mrp2, and OCT1. Journal of ethnopharmacology. 2021 Mar; 267(?):113471. doi: 10.1016/j.jep.2020.113471. [PMID: 33075440]
  • Qing Zhao, Mengjuan Wei, Shaobo Zhang, Zhenlin Huang, Bin Lu, Lili Ji. The water extract of Sophorae tonkinensis Radix et Rhizoma alleviates non-alcoholic fatty liver disease and its mechanism. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2020 Oct; 77(?):153270. doi: 10.1016/j.phymed.2020.153270. [PMID: 32702591]
  • Yongpan Huang, Xinliang Li, Xi Zhang, Jiayu Tang. Oxymatrine Ameliorates Memory Impairment in Diabetic Rats by Regulating Oxidative Stress and Apoptosis: Involvement of NOX2/NOX4. Oxidative medicine and cellular longevity. 2020; 2020(?):3912173. doi: 10.1155/2020/3912173. [PMID: 33273999]
  • Ni Deng, Lili Xie, Yongwei Li, Haishu Lin, Renhui Luo. Oxymatrine alleviates periodontitis in rats by inhibiting inflammatory factor secretion and regulating MMPs/TIMP protein expression1. Acta cirurgica brasileira. 2018 Nov; 33(11):945-953. doi: 10.1590/s0102-865020180110000001. [PMID: 30517321]
  • Jing Wu, Lin Pan, Xueqin Jin, Weihua Li, Hongbing Li, Jianmao Chen, Wen Yang. The role of oxymatrine in regulating TGF-β1 in rats with hepatic fibrosis. Acta cirurgica brasileira. 2018 Mar; 33(3):207-215. doi: 10.1590/s0102-865020180030000002. [PMID: 29668780]
  • Hui-Juan Shi, Hong-Bin Song, Le Wang, Sheng-Xiang Xiao, Kai-Ping Bo, Wei Ma. The synergy of diammonium glycyrrhizinate remarkably reduces the toxicity of oxymatrine in ICR mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2018 Jan; 97(?):19-25. doi: 10.1016/j.biopha.2017.09.039. [PMID: 29080454]
  • Jian Xu, Chengmin Li, Ziwei Li, Chan Yang, Lan Lei, Wei Ren, Yan Su, Chunping Chen. Protective effects of oxymatrine against lipopolysaccharide/D‑galactosamine‑induced acute liver failure through oxidative damage, via activation of Nrf2/HO‑1 and modulation of inflammatory TLR4‑signaling pathways. Molecular medicine reports. 2018 Jan; 17(1):1907-1912. doi: 10.3892/mmr.2017.8060. [PMID: 29138821]
  • Zhongwei Liu, Ying Lv, Yong Zhang, Fuqiang Liu, Ling Zhu, Shuo Pan, Chuan Qiu, Yan Guo, Tielin Yang, Junkui Wang. Matrine-Type Alkaloids Inhibit Advanced Glycation End Products Induced Reactive Oxygen Species-Mediated Apoptosis of Aortic Endothelial Cells In Vivo and In Vitro by Targeting MKK3 and p38MAPK Signaling. Journal of the American Heart Association. 2017 Dec; 6(12):. doi: 10.1161/jaha.117.007441. [PMID: 29197828]
  • Meifeng Liu, Sha Jin, Hao Yan, Song Du. Effect of oxymatrine HSPC liposomes on improving bioavailability, liver target distribution and hepatoprotective activity of oxymatrine. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2017 Jun; 104(?):212-220. doi: 10.1016/j.ejps.2017.03.048. [PMID: 28389275]
  • Ailing Ma, Yongya Yang, Qiuyang Wang, Yin Wang, Jing Wen, Yanli Zhang. Anti‑inflammatory effects of oxymatrine on rheumatoid arthritis in rats via regulating the imbalance between Treg and Th17 cells. Molecular medicine reports. 2017 Jun; 15(6):3615-3622. doi: 10.3892/mmr.2017.6484. [PMID: 28440447]
  • Yan Jiang, Yanxin Zhu, Qiuju Mu, Hong Luo, Yan Zhi, Xiangchun Shen. Oxymatrine provides protection against Coxsackievirus B3-induced myocarditis in BALB/c mice. Antiviral research. 2017 05; 141(?):133-139. doi: 10.1016/j.antiviral.2017.01.013. [PMID: 28115196]
  • H Ozturk, A Cetinkaya, F Yilmaz, H Ozturk. Protective effect of oxymatrine against renal ischemia/reperfusion injury in rats. Bratislavske lekarske listy. 2017; 118(4):217-222. doi: 10.4149/bll_2017_043. [PMID: 28471232]
  • Xiao-Hong Xiong, Li-Hua Huang, Yun-Ming Zhong, Xuan-Ge Cheng, Mei-Feng Cen, Gui-Xiang Wang, Lin-Quan Zang, Su-Jun Wang. Absorption mechanism of oxymatrine in cultured Madin-Darby canine kidney cell monolayers. Pharmaceutical biology. 2016 Oct; 54(10):2168-75. doi: 10.3109/13880209.2016.1149496. [PMID: 26983455]
  • Chao Wang, Hui-Xin Zhang, Han-Ying Xing, Xing Wang, Zhe Zhang. [Oxymatrine alleviates oxidative stress in fat-induced insulin resistance mice by suppressing p38MAPK pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2016 Aug; 41(15):2872-2876. doi: 10.4268/cjcmm20161521. [PMID: 28914031]
  • Hong-Wei Wang, Lei Shi, Yan-Ping Xu, Xing-Ya Qin, Qi-Zhi Wang. Oxymatrine inhibits renal fibrosis of obstructive nephropathy by downregulating the TGF-β1-Smad3 pathway. Renal failure. 2016 Jul; 38(6):945-51. doi: 10.3109/0886022x.2016.1164185. [PMID: 27050799]
  • Sha Liao, Xueyuan Jin, Jinglai Li, Tianhong Zhang, Wenpeng Zhang, Weiguo Shi, Shiyong Fan, Xiaoying Wang, Juan Wang, Bohua Zhong, Zhenqing Zhang. Effects of Silymarin, Glycyrrhizin, and Oxymatrine on the Pharmacokinetics of Ribavirin and Its Major Metabolite in Rats. Phytotherapy research : PTR. 2016 Apr; 30(4):618-26. doi: 10.1002/ptr.5567. [PMID: 26800424]
  • Wei-jiang Song, Jing Luo, Tong Wu, Shu-kun Yao. Oral oxymatrine preparation for chronic hepatitis B: A systematic review of randomized controlled trials. Chinese journal of integrative medicine. 2016 Feb; 22(2):141-9. doi: 10.1007/s11655-015-2143-0. [PMID: 26016455]
  • Lirong Liu, Yuanyuan Wang, Rui Yan, Shuang Li, Mingjun Shi, Ying Xiao, Bing Guo. Oxymatrine Inhibits Renal Tubular EMT Induced by High Glucose via Upregulation of SnoN and Inhibition of TGF-β1/Smad Signaling Pathway. PloS one. 2016; 11(3):e0151986. doi: 10.1371/journal.pone.0151986. [PMID: 27010330]
  • Guanjun Jiang, Xiuheng Liu, Min Wang, Hui Chen, Zhiyuan Chen, Tao Qiu. Oxymatrine ameliorates renal ischemia-reperfusion injury from oxidative stress through Nrf2/HO-1 pathway. Acta cirurgica brasileira. 2015 Jun; 30(6):422-9. doi: 10.1590/s0102-865020150060000008. [PMID: 26108031]
  • Hai Xiao, Yi-ni Xu, Hong Luo, Yan Chen, Yan-yan Zhang, Ling Tao, Yan Jiang, Xiang-chun Shen. [OMT inhibited TGF-β1-induced cardiac fibroblast proliferation via down-regulating p38MAPK phosphorylation in vitro]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2015 Jun; 40(11):2168-73. doi: NULL. [PMID: 26552175]
  • Wei Zhang, Jian Zhang, Yansheng Kang Liu, Jingjing Liu, Xiaoqing Wang, Qingbin Xu, Yilei Wang, Xiaoya Xu, Guidong Dai. Cardioprotective effects of oxymatrine on isoproterenol-induced heart failure via regulation of DDAH/ADMA metabolism pathway in rats. European journal of pharmacology. 2014 Dec; 745(?):29-35. doi: 10.1016/j.ejphar.2014.10.001. [PMID: 25310909]
  • Qinhui Wang, Lei Shi, Xiuling Tang, Qingwei Wang, Xueliang Dang, Yan Zhang. Pharmacokinetic study of multiple active constituents from Kushen-Gancao Decoction after oral administration in rat by HPLC-MS/MS. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2014 Aug; 965(?):19-26. doi: 10.1016/j.jchromb.2014.05.038. [PMID: 24976484]
  • Suo-bin Wang, Jian-ping Jia. Oxymatrine attenuates diabetes-associated cognitive deficits in rats. Acta pharmacologica Sinica. 2014 Mar; 35(3):331-8. doi: 10.1038/aps.2013.158. [PMID: 24442148]
  • Changrun Guo, Fengyu Han, Chunfeng Zhang, Wei Xiao, Zhonglin Yang. Protective effects of oxymatrine on experimental diabetic nephropathy. Planta medica. 2014 Mar; 80(4):269-76. doi: 10.1055/s-0033-1360369. [PMID: 24535719]
  • Yang Wang, Ye-Hua Xu, Ai-Qin Xiong, Ya-Ni Yuan, Ping Zheng, Ping Ma, Gui-Dong Dai, Qing-Bin Xu. [Protective effect of oxymatrine on chronic heart failure and ADMA metabolism pathway in isoproterenol-induced chronic heart failure in rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2014 Feb; 39(3):471-7. doi: . [PMID: 24946550]
  • Jian-Bo Wen, Fang-Qing Zhu, Wei-Guo Chen, Li-Ping Jiang, Jie Chen, Zhao-Peng Hu, Yong-Jian Huang, Zhi-Wei Zhou, Gui-Liang Wang, Hao Lin, Shu-Feng Zhou. Oxymatrine improves intestinal epithelial barrier function involving NF-κB-mediated signaling pathway in CCl4-induced cirrhotic rats. PloS one. 2014; 9(8):e106082. doi: 10.1371/journal.pone.0106082. [PMID: 25171482]
  • Xiaolei Pan, Li Wang, Dirk Gründemann, Douglas H Sweet. Inhibition of human organic cation transporters by the alkaloids matrine and oxymatrine. Fitoterapia. 2014 Jan; 92(?):206-10. doi: 10.1016/j.fitote.2013.11.009. [PMID: 24291757]
  • Ruoxi Fan, Ran Liu, Ran Ma, Kaishun Bi, Qing Li. Determination of oxymatrine and its active metabolite matrine in human plasma after administration of oxymatrine oral solution by high-performance liquid chromatography coupled with mass spectrometry. Fitoterapia. 2013 Sep; 89(?):271-7. doi: 10.1016/j.fitote.2013.05.024. [PMID: 23747322]
  • Lan Tang, Ling-Na Dong, Xiao-Juan Peng, Ye Li, Jian Shi, Fu-Yuan Zhou, Zhong-Qiu Liu. Pharmacokinetic characterization of oxymatrine and matrine in rats after oral administration of radix Sophorae tonkinensis extract and oxymatrine by sensitive and robust UPLC-MS/MS method. Journal of pharmaceutical and biomedical analysis. 2013 Sep; 83(?):179-85. doi: 10.1016/j.jpba.2013.05.003. [PMID: 23747747]
  • Lijuan Shi, Lei Shi, Hefang Zhang, Zhijuan Hu, Chao Wang, Donghui Zhang, Guangyao Song. Oxymatrine ameliorates non-alcoholic fatty liver disease in rats through peroxisome proliferator-activated receptor-α activation. Molecular medicine reports. 2013 Aug; 8(2):439-45. doi: 10.3892/mmr.2013.1512. [PMID: 23754536]
  • Hongyu Piao, Shihong Liu, Hongze Piao, Xuefeng Li, Fude Cui. Development of an osmotically-driven pellet coated with acrylic copolymers (Eudragit® RS 30 D) for the sustained release of oxymatrine, a freely water soluble drug used to treat stress ulcers (I): in vitro and in vivo evaluation in rabbits. Drug development and industrial pharmacy. 2013 Aug; 39(8):1230-7. doi: 10.3109/03639045.2012.707206. [PMID: 22873131]
  • Xiu-Yu Wang, Ming-Hao Zhang, Mei-Ling Yang, Yi-Deng Jiang, Gui-Zhong Li, Xiao-Ling Yang, Hua Xu, Jun Cao. [Effect of oxymatrine on JAK2/STAT3 signaling in renal tissues of rats with septic shock]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2013 Aug; 38(16):2696-700. doi: . [PMID: 24228589]
  • Ning-Li Chai, Shi-Ping Xu, Jun Wan, Ben-Yan Wu. [Oxymatrine could promote mesenchymal stem cell therapy in hepatic fibrosis rats: an experimental research]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. 2013 Jun; 33(6):840-4. doi: . [PMID: 23980370]
  • Xiao Yan Huang, Chang Xun Chen. Effect of oxymatrine, the active component from Radix Sophorae flavescentis (Kushen), on ventricular remodeling in spontaneously hypertensive rats. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2013 Feb; 20(3-4):202-12. doi: 10.1016/j.phymed.2012.10.012. [PMID: 23211799]
  • Hong-Yan Liu, Yu-Xiang Li, Yin-Ju Hao, Hai-Yan Wang, Xiu-Ying Dai, Tao Sun, Jian-Qiang Yu. Effects of oxymatrine on the neuropathic pain induced by chronic constriction injury in mice. CNS neuroscience & therapeutics. 2012 Dec; 18(12):1030-2. doi: 10.1111/cns.12026. [PMID: 23164255]
  • Xiao-hu Zi, Wei Zhou, Qian Chen, Mei Li, Shu-ling Gu. [The effect of oxymatrine on aging mice caused by D+ -galactose]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2012 Sep; 35(9):1455-9. doi: . [PMID: 23451502]
  • Ning-Li Chai, Qiang Fu, Hui Shi, Chang-Hao Cai, Jun Wan, Shi-Ping Xu, Ben-Yan Wu. Oxymatrine liposome attenuates hepatic fibrosis via targeting hepatic stellate cells. World journal of gastroenterology. 2012 Aug; 18(31):4199-206. doi: 10.3748/wjg.v18.i31.4199. [PMID: 22919254]
  • Yi-cheng Jian, Wei Li, Yi He, Ming Jiang, Yan-bing Liu, Wu-jun Xiong. Effect of oxymatrine on hepatic gene expression profile in experimental liver fibrosis of rats. Chinese journal of integrative medicine. 2012 Jun; 18(6):445-50. doi: 10.1007/s11655-012-1115-x. [PMID: 22821657]
  • Zhiqiang Zhang, Yanqing Wang, Ming Dong, Jianchun Cui, Daqing Rong, Qi Dong. Oxymatrine ameliorates L-arginine-induced acute pancreatitis in rats. Inflammation. 2012 Apr; 35(2):605-13. doi: 10.1007/s10753-011-9352-2. [PMID: 21633783]
  • Jinxian Gao, Zhenhong Yi, Guang Yang, Lin Yan, Lijun Tao, Shuansheng Gao, Qiuyan Pan, Yuanxu Jiang. [Effect of down-regulation of GAT-1 on analgesic action of oxysophoridine]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2011 Dec; 36(23):3315-8. doi: . [PMID: 22393743]
  • Zong-wei Li, Guo-feng Li, Jian-hong Zhang. [Pharmacokinetics and bioavailability of sustained-release tablets of matrine in dogs]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2010 Aug; 33(8):1293-6. doi: NULL. [PMID: 21213544]
  • Yuku Chen, Deyun Wang, Yuanliang Hu, Zhenhuan Guo, Junmin Wang, Xiaona Zhao, Yunpeng Fan, Liwei Guo, Shujuan Yang, Fuding Sai, Yujuan Xing. Astragalus polysaccharide and oxymatrine can synergistically improve the immune efficacy of Newcastle disease vaccine in chicken. International journal of biological macromolecules. 2010 May; 46(4):425-8. doi: 10.1016/j.ijbiomac.2010.02.004. [PMID: 20149818]
  • Jinna Cao, Jukui Sun, Xiaoyu Wang, Xinran Li, Yingjie Deng. N-trimethyl chitosan-coated multivesicular liposomes for oxymatrine oral delivery. Drug development and industrial pharmacy. 2009 Nov; 35(11):1339-47. doi: 10.3109/03639040902902427. [PMID: 19832634]
  • Wen-Xiang Zhou, Wen-Bin Zheng, Xiao-Mei Huang, Ying Zhang, Xiang-Zhi Nie, Hong-Bing Li, Da He, Lan-Qian Xie. [Effects of oxymatrine on microinflammatory state in patients undergoing continuous hemodialysis: a randomized controlled trial]. Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine. 2009 Aug; 7(8):736-40. doi: 10.3736/jcim20090806. [PMID: 19671411]
  • Yuefan Zhang, Shaozhan Wang, Yuanyuan Li, Zhenyu Xiao, Zhenlin Hu, Junping Zhang. Sophocarpine and matrine inhibit the production of TNF-alpha and IL-6 in murine macrophages and prevent cachexia-related symptoms induced by colon26 adenocarcinoma in mice. International immunopharmacology. 2008 Dec; 8(13-14):1767-72. doi: 10.1016/j.intimp.2008.08.008. [PMID: 18775799]
  • Lei Zhang, Wentao Liu, Ruowen Zhang, Zhiwei Wang, Zhenduo Shen, Xiaohui Chen, Kaishun Bi. Pharmacokinetic study of matrine, oxymatrine and oxysophocarpine in rat plasma after oral administration of Sophora flavescens Ait. extract by liquid chromatography tandem mass spectrometry. Journal of pharmaceutical and biomedical analysis. 2008 Aug; 47(4-5):892-8. doi: 10.1016/j.jpba.2008.03.019. [PMID: 18479880]
  • Lei Zhang, Zhi-Wei Wang, Jian-Wei Lian, Hao Zhou, Xiao-Hui Chen, Kai-Shun Bi. [Simultaneous determination of matrine, oxysophocarpin and oxymatrine in rat plasma by HPLC-MS and its application in the pharmacokinetic study]. Yao xue xue bao = Acta pharmaceutica Sinica. 2008 Aug; 43(8):843-7. doi: . [PMID: 18956778]
  • Wei Zhang, Bing-ren Xiang, Peng-cheng Ma. Determination of oxymatrine in human plasma by LC-MS and study on its pharmacokinetics. Journal of chromatographic science. 2008 Jul; 46(6):529-33. doi: 10.1093/chromsci/46.6.529. [PMID: 18647475]
  • Bao-Sheng Shen, Xin-Wen Song. [Effects of oxymatrine on serum cytokines and hepatic fibrotic indexes in patients with chronic hepatitis B]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. 2008 Jan; 28(1):17-9. doi: NULL. [PMID: 18418962]
  • Jinpeng Zhao, Shoujiang Yu, Liquan Tong, Feng Zhang, Xian Jiang, Shangha Pan, Hongchi Jiang, Xueying Sun. Oxymatrine attenuates intestinal ischemia/reperfusion injury in rats. Surgery today. 2008; 38(10):931-7. doi: 10.1007/s00595-008-3785-8. [PMID: 18820869]
  • Yu-Mei Han, Dan Yan, Hai-Long Yuan. [Study on bioavilability of oxymatrine-phospholipid complex in rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2007 Dec; 32(23):2508-10. doi: NULL. [PMID: 18330245]
  • Xing Wang, Wei Zhang, Liuyin Fan, Chengxi Cao. [Determination of oxymatrine in urine samples by capillary electrophoresis with stacking induced by moving reaction boundary]. Se pu = Chinese journal of chromatography. 2007 Sep; 25(5):694-8. doi: NULL. [PMID: 18161320]
  • Zhong-qing Yu, Yan Wang, Qing-you Zeng, Li-Yan Chen, Jian-xun Wang, Jian-xun Yang, Shu-hua Li, Bao-shan Yang. [Observations on clinic curative effect of oxymatrine to cure hemorrhagic fever with renal syndrome (HFRS)]. Zhonghua yi xue za zhi. 2007 Aug; 87(30):2126-8. doi: NULL. [PMID: 17988533]
  • Yiqi Wang, Yuanyuan Ma, Xiaohong Li, Feng Qin, Xiumei Lu, Famei Li. Simultaneous determination and pharmacokinetic study of oxymatrine and matrine in beagle dog plasma after oral administration of Kushen formula granule, oxymatrine and matrine by LC-MS/MS. Biomedical chromatography : BMC. 2007 Aug; 21(8):876-82. doi: 10.1002/bmc.834. [PMID: 17431934]
  • Xing Wang, Wei Zhang, Liu-Yin Fan, Bing Hao, Ai-Niu Ma, Cheng-Xi Cao, Yong-Xiang Wang. Sensitive quantitative determination of oxymatrine and matrine in rat plasma by capillary electrophoresis with stacking induced by moving reaction boundary. Analytica chimica acta. 2007 Jul; 594(2):290-6. doi: 10.1016/j.aca.2007.05.024. [PMID: 17586127]
  • Guan Ye, Hai-Yan Zhu, Zhi-Xiong Li, Chun-Hui Ma, Ming-Song Fan, Zhao-Lin Sun, Cheng-Gang Huang. LC-MS characterization of efficacy substances in serum of experimental animals treated with Sophora flavescens extracts. Biomedical chromatography : BMC. 2007 Jun; 21(6):655-60. doi: 10.1002/bmc.805. [PMID: 17370298]
  • Chen Chen, Yu Jin. [Effects of oxymatrine on expression of nuclear factor kappa B in kidneys of rats with adriamycin-induced chronic renal fibrosis]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. 2007 Mar; 27(3):345-8. doi: NULL. [PMID: 17425988]
  • Ai-ling Zhou, Yu-juan Zhu, Ya-e Hu, Jia-hui Mao, Dao-rong Jiang. [Effect of acupoint-injection of oxymatrine on experimental hepatic carcinoma and study on the mechanism]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. 2007 Jan; 27(1):48-52. doi: NULL. [PMID: 17378204]
  • Xiao-luan Wu, Tai-jun Hang, Jian-ping Shen, Yin-di Zhang. Determination and pharmacokinetic study of oxymatrine and its metabolite matrine in human plasma by liquid chromatography tandem mass spectrometry. Journal of pharmaceutical and biomedical analysis. 2006 Jun; 41(3):918-24. doi: 10.1016/j.jpba.2006.01.029. [PMID: 16500065]
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