Aesculin (BioDeep_00000000254)

 

Secondary id: BioDeep_00000338929, BioDeep_00000863178

natural product human metabolite PANOMIX_OTCML-2023 Endogenous


代谢物信息卡片


7-hydroxy-6-[3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-chromen-2-one hydrate;Esculin Sesquihydrate

化学式: C15H16O9 (340.0794286)
中文名称: 马粟树皮苷, 秦皮甲素, 七叶灵, 七叶甙, 七叶苷, 秦皮甲素
谱图信息: 最多检出来源 Viridiplantae(plant) 0.07%

分子结构信息

SMILES: C1=CC(=O)OC2=CC(=C(C=C21)OC3C(C(C(C(O3)CO)O)O)O)O
InChI: InChI=1S/C15H16O9/c16-5-10-12(19)13(20)14(21)15(24-10)23-9-3-6-1-2-11(18)22-8(6)4-7(9)17/h1-4,10,12-17,19-21H,5H2

描述信息

Esculin is a hydroxycoumarin that is the 6-O-beta-D-glucoside of esculetin. It has a role as an antioxidant and a metabolite. It is a beta-D-glucoside and a hydroxycoumarin. It is functionally related to an esculetin.
Esculin is found in barley. Vitamin C2 is generally considered a bioflavanoid, related to vitamin P esculin is a glucoside that naturally occurs in the horse chestnut (Aesculus hippocastanum), California Buckeye (Aesculus californica) and in daphnin (the dark green resin of Daphne mezereum). Esculin belongs to the family of Glycosyl Compounds. These are carbohydrate derivatives in which a sugar group is bonded through its anmoeric carbonA to another group via a C-, S-,N-,O-, or Se- glycosidic bond.
Esculin is a natural product found in Ficus septica, Gardenia jasminoides, and other organisms with data available.
A derivative of COUMARIN with molecular formula C15H16O9.
See also: Horse Chestnut (part of); Aesculus hippocastanum bark (part of).
Aesculin is found in barley. Vitamin C2 is generally considered a bioflavanoid, related to vitamin P Aesculin is a glucoside that naturally occurs in the horse chestnut (Aesculus hippocastanum), California Buckeye (Aesculus californica) and in daphnin (the dark green resin of Daphne mezereum)
Vitamin C2 is generally considered a bioflavanoid, related to vitamin P
A hydroxycoumarin that is the 6-O-beta-D-glucoside of esculetin.
Acquisition and generation of the data is financially supported in part by CREST/JST.
Esculin, a fluorescent coumarin glucoside, is an active ingredient of ash bark[1]. Esculin ameliorates cognitive impairment in experimental diabetic nephropathy (DN), and exerts anti?oxidative stress and anti?inflammatory effects, via the MAPK signaling pathway[2].
Esculin, a fluorescent coumarin glucoside, is an active ingredient of ash bark[1]. Esculin ameliorates cognitive impairment in experimental diabetic nephropathy (DN), and exerts anti?oxidative stress and anti?inflammatory effects, via the MAPK signaling pathway[2].

同义名列表

72 个代谢物同义名

7-hydroxy-6-[3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-chromen-2-one hydrate;Esculin Sesquihydrate; 7-hydroxy-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-2H-chromen-2-one; 7-hydroxy-6-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yloxy)-2H-chromen-2-one; 7-hydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy- 6-(hydroxymethyl)-2-tetrahydropyranyl]oxy}-2-chromenone; 6-[(2S,3R,4S,5S,6R)-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-7-oxidanyl-chromen-2-one; 7-hydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-2H-chromen-2-one; 7-hydroxy-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-2-one; 2H-1-Benzopyran-2-one, 6-(.beta.-D-glucopyranosyloxy)-7-hydroxy-; 2H-1-Benzopyran-2-one, 6-(beta-D-glucopyranosyloxy)-7-hydroxy-; 6-(.beta.-D-Glucopyranosyloxy)-7-hydroxy-2H-1-benzopyran-2-one; 6-(beta-D-Glucopyranosyloxy)-7-hydroxy-2H-1-benzopyran-2-one; 6-(b-D-Glucopyranosyloxy)-7-hydroxy-2H-1-benzopyran-2-one; 6-(Β-D-glucopyranosyloxy)-7-hydroxy-2H-1-benzopyran-2-one; Esculin, European Pharmacopoeia (EP) Reference Standard; 7-hydroxy-2-oxo-2H-chromen-6-yl beta-D-glucopyranoside; 6-(.beta.-D-Glucopyranosyloxy)-7-hydroxy-cumarin; 6-(beta-D-Glucopyranosyloxy)-7-hydroxy-cumarin; 6-(beta-D-Glucopyranosyloxy)-7-hydroxycoumarin; 7-Hydroxycoumarin-6-yl beta-D-Glucopyranoside; 6-(Β-D-glucopyranosyloxy)-7-hydroxycoumarin; 6-(Β-D-glucopyranosyloxy)-7-hydroxy-cumarin; 6-(b-D-Glucopyranosyloxy)-7-hydroxy-cumarin; 7-Hydroxy-6-glucosyloxy-2H-chromene; 6,7-Dihydroxycoumarin-6-O-glucoside; 7-Hydroxy-6-glucosyloxy-2H-chromen; 6,7-Dihydroxycoumarin 6-glucoside; 7-Hydroxy-6-cumarinyl-glucosid; Esculetin 6-.beta.-D-glucoside; Esculetin 6-beta-D-glucoside; Esculetin 6-b-D-glucoside; Esculetin 6-β-D-glucoside; Esculetin 6-O-glucoside; Aesculetin glukosid; ESCULOSIDE [WHO-DD]; Aesculin (Esculin); esculetin glukosid; AESCULINUM [HPUS]; ESCULOSIDE [JAN]; Spectrum3_000731; Spectrum2_000576; Spectrum5_000845; BCBcMAP01_000202; Spectrum4_001923; UNII-1Y1L18LQAF; ESCULIN [INCI]; Schillerstoff; DivK1c_000956; ESCULIN [MI]; KBio2_003409; KBio1_000956; Tox21_110453; Enallachrome; KBio2_000841; KBio2_005977; KBio3_001502; (-)-Esculin; SMP1_000008; IDI1_000956; Aesculinum; Esculoside; 1Y1L18LQAF; Vitamin C2; Venoplant; Bicolorin; Crataegin; aesculin; Esculine; Esculina; Escosyl; Esculin; 7OU; Esculin Sesquihydrate



数据库引用编号

40 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(2)

PlantCyc(2)

代谢反应

118 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(3)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(115)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

106 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Xiaoke Ji, Zongpin Chen, Weifan Lin, Qifang Wu, Yu Wu, Yan Hong, Haibin Tong, Changxiong Wang, Ya Zhang. Esculin induces endoplasmic reticulum stress and drives apoptosis and ferroptosis in colorectal cancer via PERK regulating eIF2α/CHOP and Nrf2/HO-1 cascades. Journal of ethnopharmacology. 2024 Jun; 328(?):118139. doi: 10.1016/j.jep.2024.118139. [PMID: 38561058]
  • Noha Mokhtar Abd-El-Aziz, Mohamed Saeed Hifnawy, Rehab Ahmed Lotfy, Inas Youssef Younis. LC/MS/MS and GC/MS/MS metabolic profiling of Leontodon hispidulus, in vitro and in silico anticancer activity evaluation targeting hexokinase 2 enzyme. Scientific reports. 2024 03; 14(1):6872. doi: 10.1038/s41598-024-57288-4. [PMID: 38519553]
  • Zheng Lv, Boyang Wang, Bianli Wang, Huimin Zhang. In vivo comprehensive metabolite profiling of esculetin and esculin derived from chicory in hyperuricemia rats using ultra-high-performance liquid chromatography coupled with quadrupole-orbitrap high-resolution mass spectrometry. Journal of separation science. 2024 Jan; 47(1):e2300664. doi: 10.1002/jssc.202300664. [PMID: 38010472]
  • Wei Sun, Qinggang Yin, Huihua Wan, Ranran Gao, Chao Xiong, Chong Xie, Xiangxiao Meng, Yaolei Mi, Xiaotong Wang, Caixia Wang, Weiqiang Chen, Ziyan Xie, Zheyong Xue, Hui Yao, Peng Sun, Xuehua Xie, Zhigang Hu, David R Nelson, Zhichao Xu, Xinxiao Sun, Shilin Chen. Characterization of the horse chestnut genome reveals the evolution of aescin and aesculin biosynthesis. Nature communications. 2023 Oct; 14(1):6470. doi: 10.1038/s41467-023-42253-y. [PMID: 37833361]
  • Chen Gao, Sean J V Marker, Carsten Gundlach, Henning F Poulsen, Tomas Bohr, Alexander Schulz. Tracing the opposing assimilate and nutrient flows in live conifer needles. Journal of experimental botany. 2023 Sep; ?(?):. doi: 10.1093/jxb/erad334. [PMID: 37668473]
  • Zheng-Ming Qian, Meng-Qi Wu, Guo-Ying Tan, Li-Ling Jin, Ning Li, Ju-Ying Xie. [Rapid determination of aesculin and aesculetin in Fraxini Cortex by high performance liquid chromatography-ultraviolet at equal absorption wavelength]. Se pu = Chinese journal of chromatography. 2023 Aug; 41(8):690-697. doi: 10.3724/sp.j.1123.2023.03018. [PMID: 37534556]
  • Qinggang Yin, Tianze Wu, Ranran Gao, Lan Wu, Yuhua Shi, Xingwen Wang, Mengyue Wang, Zhichao Xu, Yueliang Zhao, Xiaojia Su, Yanyan Su, Xiaoyan Han, Ling Yuan, Li Xiang, Shilin Chen. Multi-omics reveal key enzymes involved in the formation of phenylpropanoid glucosides in Artemisia annua. Plant physiology and biochemistry : PPB. 2023 Jun; 201(?):107795. doi: 10.1016/j.plaphy.2023.107795. [PMID: 37301186]
  • Jiangwei Ni, Ge Li, Ningfeng Dai, Zijiao Quan, Haibin Tong, Yu Liu. Esculin alleviates LPS-induced acute lung injury via inhibiting neutrophil recruitment and migration. International immunopharmacology. 2023 Apr; 119(?):110177. doi: 10.1016/j.intimp.2023.110177. [PMID: 37068336]
  • Amin Arif, Ruhul Quds, Samreen Salam, Riaz Mahmood. Esculin protects human blood cells from bioallethrin-induced toxicity: An ex vivo study. Pesticide biochemistry and physiology. 2023 Apr; 191(?):105375. doi: 10.1016/j.pestbp.2023.105375. [PMID: 36963944]
  • Chun-Xiao Li, Jing-Chun Li, Jiang Lai, Ying Liu. The pharmacological and pharmacokinetic properties of esculin: A comprehensive review. Phytotherapy research : PTR. 2022 Jun; 36(6):2434-2448. doi: 10.1002/ptr.7470. [PMID: 35599456]
  • Changhao Bao, Min Shi, Wenwen Ma, Jun Li, Xianju Huang, Han Cheng. Simultaneous determination of aesculin and aesculetin and their interactions with DNA using carbon fiber microelectrode modified by Pt-Au bimetallic nanoparticles. Analytica chimica acta. 2022 Apr; 1202(?):339664. doi: 10.1016/j.aca.2022.339664. [PMID: 35341516]
  • Walaa H El-Maadawy, Marwa Hassan, Ehab Hafiz, Mohamed H Badawy, Samir Eldahshan, AbdulRahman AbuSeada, Maha A M El-Shazly, Mosad A Ghareeb. Co-treatment with Esculin and erythropoietin protects against renal ischemia-reperfusion injury via P2X7 receptor inhibition and PI3K/Akt activation. Scientific reports. 2022 04; 12(1):6239. doi: 10.1038/s41598-022-09970-8. [PMID: 35422072]
  • Xi-Ding Yang, Zhuo Chen, Ling Ye, Jing Chen, Yong-Yu Yang. Esculin protects against methionine choline-deficient diet-induced non-alcoholic steatohepatitis by regulating the Sirt1/NF-κB p65 pathway. Pharmaceutical biology. 2021 Dec; 59(1):922-932. doi: 10.1080/13880209.2021.1945112. [PMID: 34243681]
  • Joanna Sumorek-Wiadro, Adrian Zając, Ewa Langner, Krystyna Skalicka-Woźniak, Aleksandra Maciejczyk, Wojciech Rzeski, Joanna Jakubowicz-Gil. Antiglioma Potential of Coumarins Combined with Sorafenib. Molecules (Basel, Switzerland). 2020 Nov; 25(21):. doi: 10.3390/molecules25215192. [PMID: 33171577]
  • Yue Liang, Chuyan Jiang, Yang Liu, Yuerong Gao, Jingyun Lu, Palinuer Aiwaili, Zhangjun Fei, Cai-Zhong Jiang, Bo Hong, Chao Ma, Junping Gao. Auxin Regulates Sucrose Transport to Repress Petal Abscission in Rose (Rosa hybrida). The Plant cell. 2020 11; 32(11):3485-3499. doi: 10.1105/tpc.19.00695. [PMID: 32843436]
  • Cristina Martins Rodrigues, Christina Müdsam, Isabel Keller, Wolfgang Zierer, Olaf Czarnecki, José María Corral, Frank Reinhardt, Petra Nieberl, Karin Fiedler-Wiechers, Frederik Sommer, Michael Schroda, Timo Mühlhaus, Karsten Harms, Ulf-Ingo Flügge, Uwe Sonnewald, Wolfgang Koch, Frank Ludewig, H Ekkehard Neuhaus, Benjamin Pommerrenig. Vernalization Alters Sink and Source Identities and Reverses Phloem Translocation from Taproots to Shoots in Sugar Beet. The Plant cell. 2020 10; 32(10):3206-3223. doi: 10.1105/tpc.20.00072. [PMID: 32769131]
  • R S Serralha, I F Rodrigues, A Bertolini, D Y Lima, M Nascimento, M G Mouro, G R Punaro, I Visoná, A M Rodrigues, E M S Higa. Esculin reduces P2X7 and reverses mitochondrial dysfunction in the renal cortex of diabetic rats. Life sciences. 2020 Aug; 254(?):117787. doi: 10.1016/j.lfs.2020.117787. [PMID: 32417372]
  • Rabih Mehdi, Christian E Lamm, Ravi Bodampalli Anjanappa, Christina Müdsam, Muhammad Saeed, Janine Klima, Max E Kraner, Frank Ludewig, Michael Knoblauch, Wilhelm Gruissem, Uwe Sonnewald, Wolfgang Zierer. Symplasmic phloem unloading and radial post-phloem transport via vascular rays in tuberous roots of Manihot esculenta. Journal of experimental botany. 2019 10; 70(20):5559-5573. doi: 10.1093/jxb/erz297. [PMID: 31232453]
  • Gokhan Zengin, Mehmet Yavuz Paksoy, Muhammad Zakariyyah Aumeeruddy, Jasmina Glamocilja, Marina Sokovic, Alina Diuzheva, József Jekő, Zoltán Cziáky, Maria João Rodrigues, Luisa Custodio, Mohamad Fawzi Mahomoodally. New insights into the chemical profiling, cytotoxicity and bioactivity of four Bunium species. Food research international (Ottawa, Ont.). 2019 09; 123(?):414-424. doi: 10.1016/j.foodres.2019.05.013. [PMID: 31284993]
  • Xinlei Tian, Zhonglu Peng, Shangpeng Luo, Shaolong Zhang, Baohui Li, Changlin Zhou, Hongye Fan. Aesculin protects against DSS-Induced colitis though activating PPARγ and inhibiting NF-кB pathway. European journal of pharmacology. 2019 Aug; 857(?):172453. doi: 10.1016/j.ejphar.2019.172453. [PMID: 31202807]
  • Aleksandra Owczarek, Arkadiusz Kłys, Monika A Olszewska. A validated 1H qNMR method for direct and simultaneous quantification of esculin, fraxin and (-)-epicatechin in Hippocastani cortex. Talanta. 2019 Jan; 192(?):263-269. doi: 10.1016/j.talanta.2018.09.036. [PMID: 30348388]
  • Kirsten Knox. Measuring Phloem Transport Velocity in Arabidopsis Seedlings Using the Fluorescent Coumarin Glucoside, Esculin. Methods in molecular biology (Clifton, N.J.). 2019; 2014(?):195-201. doi: 10.1007/978-1-4939-9562-2_16. [PMID: 31197797]
  • Theresa Rottmann, Ruth Stadler. Measuring Sucrose Transporter Activities Using a Protoplast-Esculin Assay. Methods in molecular biology (Clifton, N.J.). 2019; 2014(?):253-266. doi: 10.1007/978-1-4939-9562-2_21. [PMID: 31197802]
  • Aiyun Liu, Yongbin Shen, Yaju Du, Jing Chen, Fenghua Pei, Weiran Fu, Jiutao Qiao. Esculin prevents Lipopolysaccharide/D-Galactosamine-induced acute liver injury in mice. Microbial pathogenesis. 2018 Dec; 125(?):418-422. doi: 10.1016/j.micpath.2018.10.003. [PMID: 30290266]
  • Tainá Neves Ferreira, Daniela Pita-Pereira, Samara Graciane Costa, Reginaldo Peçanha Brazil, Caroline Silva Moraes, Hector Manuel Díaz-Albiter, Fernando Ariel Genta. Transmission blocking sugar baits for the control of Leishmania development inside sand flies using environmentally friendly beta-glycosides and their aglycones. Parasites & vectors. 2018 Nov; 11(1):614. doi: 10.1186/s13071-018-3122-z. [PMID: 30501613]
  • Irshad Ahmad, Swati Sharma, Neha Gupta, Qudsia Rashid, Mohammad Abid, Mohammad Z Ashraf, Mohamad Aman Jairajpuri. Antithrombotic potential of esculin 7, 3', 4', 5', 6'-O-pentasulfate (EPS) for its role in thrombus reduction using rat thrombosis model. International journal of biological macromolecules. 2018 Nov; 119(?):360-368. doi: 10.1016/j.ijbiomac.2018.07.048. [PMID: 30009901]
  • Yuanli Zhou, Xuanguo Zhang, Chao Li, Xin Yuan, Lihua Han, Zheng Li, Xiaobin Tan, Jie Song, Gang Wang, Xiaobin Jia, Liang Feng, Xiting Qiao, Jiping Liu. Research on the pharmacodynamics and mechanism of Fraxini Cortex on hyperuricemia based on the regulation of URAT1 and GLUT9. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2018 Oct; 106(?):434-442. doi: 10.1016/j.biopha.2018.06.163. [PMID: 29990831]
  • Kirsten Knox, Andrea Paterlini, Simon Thomson, Karl Oparka. The Coumarin Glucoside, Esculin, Reveals Rapid Changes in Phloem-Transport Velocity in Response to Environmental Cues. Plant physiology. 2018 10; 178(2):795-807. doi: 10.1104/pp.18.00574. [PMID: 30111635]
  • Zhibin Wang, Wenbo Zhu, Hua Liu, Gaosong Wu, Mengmeng Song, Bingyou Yang, Deqiang Yang, Qiuhong Wang, Haixue Kuang. Simultaneous Determination of Aesculin, Aesculetin, Fraxetin, Fraxin and Polydatin in Beagle Dog Plasma by UPLC-ESI-MS/MS and Its Application in a Pharmacokinetic Study after Oral Administration Extracts of Ledum palustre L. Molecules (Basel, Switzerland). 2018 Sep; 23(9):. doi: 10.3390/molecules23092285. [PMID: 30205426]
  • Yu Song, Xiaochun Wang, Shengkai Qin, Siheng Zhou, Jiaolun Li, Yue Gao. Esculin ameliorates cognitive impairment in experimental diabetic nephropathy and induces anti-oxidative stress and anti-inflammatory effects via the MAPK pathway. Molecular medicine reports. 2018 05; 17(5):7395-7402. doi: 10.3892/mmr.2018.8727. [PMID: 29568860]
  • Janggyoo Choi, Kee Dong Yoon, Jinwoong Kim. Chemical constituents from Taraxacum officinale and their α-glucosidase inhibitory activities. Bioorganic & medicinal chemistry letters. 2018 02; 28(3):476-481. doi: 10.1016/j.bmcl.2017.12.014. [PMID: 29254644]
  • Vivekjot Brar, Gurpreet Kaur. Preparation of Chitosan Okra Nanoparticles: Optimization and Evaluation as Mucoadhesive Drug Delivery System. Pharmaceutical nanotechnology. 2018; 6(3):180-191. doi: 10.2174/2211738506666180813122437. [PMID: 30101724]
  • Mengmeng Zhang, Xuan Xin, Furao Lai, Xiaoyuan Zhang, Xiaofeng Li, Hui Wu. Cellular Transport of Esculin and Its Acylated Derivatives in Caco-2 Cell Monolayers and Their Antioxidant Properties in Vitro. Journal of agricultural and food chemistry. 2017 Aug; 65(34):7424-7432. doi: 10.1021/acs.jafc.7b02525. [PMID: 28805379]
  • Mercedes Nieves-Morión, Sigal Lechno-Yossef, Rocío López-Igual, José E Frías, Vicente Mariscal, Dennis J Nürnberg, Conrad W Mullineaux, C Peter Wolk, Enrique Flores. Specific Glucoside Transporters Influence Septal Structure and Function in the Filamentous, Heterocyst-Forming Cyanobacterium Anabaena sp. Strain PCC 7120. Journal of bacteriology. 2017 04; 199(7):. doi: 10.1128/jb.00876-16. [PMID: 28096449]
  • Lianrong Yang, Xin Meng, Xiaojin Yu, Haixue Kuang. Simultaneous determination of anemoside B4, phellodendrine, berberine, palmatine, obakunone, esculin, esculetin in rat plasma by UPLC-ESI-MS/MS and its application to a comparative pharmacokinetic study in normal and ulcerative colitis rats. Journal of pharmaceutical and biomedical analysis. 2017 Feb; 134(?):43-52. doi: 10.1016/j.jpba.2016.11.021. [PMID: 27875787]
  • Imen Mokdad Bzeouich, Nadia Mustapha, Mouna Maatouk, Kamel Ghedira, Mohamed Ghoul, Leila Chekir-Ghedira. Genotoxic and anti-genotoxic effects of esculin and its oligomer fractions against mitomycin C-induced DNA damages in mice. Regulatory toxicology and pharmacology : RTP. 2016 Dec; 82(?):48-52. doi: 10.1016/j.yrtph.2016.11.002. [PMID: 27825835]
  • Weifeng Li, Yu Wang, Xiumei Wang, Zehong He, Fang Liu, Wenbing Zhi, Hailin Zhang, Xiaofeng Niu. Esculin attenuates endotoxin shock induced by lipopolysaccharide in mouse and NO production in vitro through inhibition of NF-κB activation. European journal of pharmacology. 2016 Nov; 791(?):726-734. doi: 10.1016/j.ejphar.2016.10.013. [PMID: 27746168]
  • Daniel Tierney, Sarah D Copsey, Trefor Morris, John D Perry. A new chromogenic medium for isolation of Bacteroides fragilis suitable for screening for strains with antimicrobial resistance. Anaerobe. 2016 Jun; 39(?):168-72. doi: 10.1016/j.anaerobe.2016.04.003. [PMID: 27060277]
  • Yinan Wang, Min Zhao, Yingfu Ou, Bowen Zeng, Xinyu Lou, Miao Wang, Chunjie Zhao. Metabolic profile of esculin in rats by ultra high performance liquid chromatography combined with Fourier transform ion cyclotron resonance mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2016 May; 1020(?):120-8. doi: 10.1016/j.jchromb.2016.03.027. [PMID: 27038404]
  • Yue-Hua Wang, Yan-Hong Liu, Guo-Rong He, Yang Lv, Guan-Hua Du. Esculin improves dyslipidemia, inflammation and renal damage in streptozotocin-induced diabetic rats. BMC complementary and alternative medicine. 2015 Nov; 15(?):402. doi: 10.1186/s12906-015-0817-y. [PMID: 26552745]
  • Zaizhi Liu, Huiyan Gu, Lei Yang. An approach of ionic liquids/lithium salts based microwave irradiation pretreatment followed by ultrasound-microwave synergistic extraction for two coumarins preparation from Cortex fraxini. Journal of chromatography. A. 2015 Oct; 1417(?):8-20. doi: 10.1016/j.chroma.2015.09.037. [PMID: 26411478]
  • Shaheed Ur Rehman, In Sook Kim, Ki Sung Kang, Hye Hyun Yoo. HPLC Determination of Esculin and Esculetin in Rat Plasma for Pharmacokinetic Studies. Journal of chromatographic science. 2015 Sep; 53(8):1322-7. doi: 10.1093/chromsci/bmv014. [PMID: 25713108]
  • Laura Zanon, Rachele Falchi, Aleksandra Hackel, Christina Kühn, Giannina Vizzotto. Expression of peach sucrose transporters in heterologous systems points out their different physiological role. Plant science : an international journal of experimental plant biology. 2015 Sep; 238(?):262-72. doi: 10.1016/j.plantsci.2015.06.014. [PMID: 26259193]
  • Michael Knoblauch, Marc Vendrell, Erica de Leau, Andrea Paterlini, Kirsten Knox, Tim Ross-Elliot, Anke Reinders, Stephen A Brockman, John Ward, Karl Oparka. Multispectral phloem-mobile probes: properties and applications. Plant physiology. 2015 Apr; 167(4):1211-20. doi: 10.1104/pp.114.255414. [PMID: 25653316]
  • Massimiliano Tattini, Martina Di Ferdinando, Cecilia Brunetti, Andrea Goti, Susanna Pollastri, Chandra Bellasio, Cristiana Giordano, Alessio Fini, Giovanni Agati. Esculetin and esculin (esculetin 6-O-glucoside) occur as inclusions and are differentially distributed in the vacuole of palisade cells in Fraxinus ornus leaves: a fluorescence microscopy analysis. Journal of photochemistry and photobiology. B, Biology. 2014 Nov; 140(?):28-35. doi: 10.1016/j.jphotobiol.2014.06.012. [PMID: 25063983]
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