Phenylephrine (BioDeep_00000002480)
Secondary id: BioDeep_00000400186, BioDeep_00000405516
natural product human metabolite blood metabolite
代谢物信息卡片
(R)-3-Hydroxy-alpha-((methylamino)methyl)benzenemethanol
化学式: C9H13NO2 (167.09462380000002)
中文名称: 去氧肾上腺素碱, L-苯肾上腺素
谱图信息:
最多检出来源 Homo sapiens(urine) 0.65%
Reviewed
Last reviewed on 2024-07-09.
Cite this Page
Phenylephrine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China.
https://query.biodeep.cn/s/phenylephrine (retrieved
2024-09-17) (BioDeep RN: BioDeep_00000002480). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
分子结构信息
SMILES: CNCC(C1=CC(=CC=C1)O)O
InChI: InChI=1/C9H13NO2/c1-10-6-9(12)7-3-2-4-8(11)5-7/h2-5,9-12H,6H2,1H3/t9-/m0/s1
描述信息
Phenylephrine is an alpha-adrenergic agonist used as a mydriatic, nasal decongestant, and cardiotonic agent (PubChem). Phenylephrine is used as a decongestant, available as an oral medicine or as a nasal spray. Phenylephrine is not the most common over-the-counter (OTC) decongestant (wikipedia).
(R)-(-)-Phenylephrine is a selective α1-adrenoceptor agonist primarily used as a decongestant.
同义名列表
76 个代谢物同义名
(R)-3-Hydroxy-alpha-((methylamino)methyl)benzenemethanol; (-)-m-Hydroxy-alpha-(methylaminomethyl)benzyl alcohol; (-)-m-Hydroxy-α-(methylaminomethyl)benzyl alcohol; (-)-m-Hydroxy-a-(methylaminomethyl)benzyl alcohol; 3-[(1R)-1-hydroxy-2-(methylamino)ethyl]phenol; L-(3-Hydroxyphenyl)-N-methylethanolamine; Ocu-phrin sterile ophthalmic solution; Neo-synephrine pediatric nasal drops; (R)-(-)-Phenylephrine hydrochloride; Relief eye drops for red eyes; Ocu-phrin sterile eye drops; Phenylephrine hydrochloride; Neo-synephrine nasal drops; Neo-synephrine nasal jelly; m-Methylaminoethanolphenol; Neo-synephrine nasal spray; Alconefrin nasal drops 50; Alconefrin nasal spray 25; Alconefrin nasal drops 25; Alconefrin nasal drops 12; Nostril spray pump mild; Tannate, phenylephrine; (R)-(-)-Phenylephrine; Phenylephrine tannate; Phenylephrine minims; Minims phenylephrine; R(-)-Phenylephrine; Nostril spray pump; Prefrin liquifilm; Phenylephrinum; Metasynephrine; Neo-synephrine; Neo synephrine; Neosynephrine; Metaoxedrinum; Phenylephrine; Spersaphrine; m-Synephrine; Metasympatol; Metaoxedrine; R(-)-Mezaton; Fenilefrina; Dionephrine; m-Sympathol; Alcon efrin; Isopto frin; Metaoxedrin; dl-Mesatone; Vicks sinex; Ocugestrin; Pyracort D; m-Oxedrine; m-Sympatol; Mesatonum; Phenoptic; Biomydrin; Ak-dilate; Ak-nefrin; Dilatair; Visadron; Adrianol; Mesatone; Neophryn; Duration; Isophrin; I-phrine; Isophrim; Neofrin; Nostril; Doktors; Rhinall; Mesaton; Mydfrin; Prefrin; Mezaton; L-Phenylephrine
数据库引用编号
39 个数据库交叉引用编号
- ChEBI: CHEBI:8093
- KEGG: C07441
- KEGGdrug: D08365
- PubChem: 6041
- PubChem: 4782
- HMDB: HMDB0002182
- Metlin: METLIN699
- DrugBank: DB00388
- ChEMBL: CHEMBL1215
- Wikipedia: Phenylephrine
- MeSH: Phenylephrine
- foodb: FDB022891
- chemspider: 5818
- CAS: 59-42-7
- MoNA: EQ333902
- MoNA: EQ333905
- MoNA: PS002003
- MoNA: EQ333906
- MoNA: KO001650
- MoNA: EQ333904
- MoNA: KO001648
- MoNA: KO001647
- MoNA: PS002001
- MoNA: KO003782
- MoNA: KO001646
- MoNA: EQ333901
- MoNA: KO003778
- MoNA: EQ333903
- MoNA: KO003781
- MoNA: PR100009
- MoNA: PS002002
- MoNA: PS002004
- MoNA: KO001649
- MoNA: KO003779
- MoNA: KO003780
- PMhub: MS000002763
- NIKKAJI: J8.601K
- RefMet: Phenylephrine
- medchemexpress: HY-B0769
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Kaijing Yang, Xiaoli Shan, Yang Songru, Mengwei Fu, Pei Zhao, Wei Guo, Ming Xu, Huihua Chen, Rong Lu, Chen Zhang. Network pharmacology integrated with experimental validation to elucidate the mechanisms of action of the Guizhi-Gancao Decoction in the treatment of phenylephrine-induced cardiac hypertrophy.
Pharmaceutical biology.
2024 Dec; 62(1):456-471. doi:
10.1080/13880209.2024.2354335. [PMID: 38773737] - Sheba R David, Penny Pei Ni Lai, Jestin Chellian, Srikumar Chakravarthi, Rajan Rajabalaya. Influence of rutin and its combination with metformin on vascular functions in type 1 diabetes.
Scientific reports.
2023 08; 13(1):12423. doi:
10.1038/s41598-023-39442-6. [PMID: 37528147] - Yimeng Cui, Peiwei Wang, Mengli Li, Yujue Wang, Xinmiao Tang, Jingang Cui, Yu Chen, Teng Zhang. Cinnamic acid mitigates left ventricular hypertrophy and heart failure in part through modulating FTO-dependent N6-methyladenosine RNA modification in cardiomyocytes.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 Jul; 165(?):115168. doi:
10.1016/j.biopha.2023.115168. [PMID: 37453198] - Dan He, Hai Hu, Liang Hong, Luming Zhang, Xuehao Lu, Wan-Jie Gu, Jun Lyu, Haiyan Yin. Norepinephrine combined with phenylephrine versus norepinephrine in patients with septic shock: a retrospective cohort study.
BMC infectious diseases.
2023 Apr; 23(1):221. doi:
10.1186/s12879-023-08142-x. [PMID: 37029365] - Qian-Wen Wang, Jia-Yao Xu, Hui-Xin Li, Yu-Dong Su, Jia-Wen Song, Zhi-Peng Song, Sha-Sha Song, Bo Dong, Shuang-Xi Wang, Bin Li. A simple and accurate method to quantify real-time contraction of vascular smooth muscle cell in vitro.
Vascular pharmacology.
2023 04; 149(?):107146. doi:
10.1016/j.vph.2023.107146. [PMID: 36724828] - Ana Bárbara D Pereira, José Hugo de Sousa Gomes, Aline Carvalho Pereira, Rodrigo Maia de Pádua, Steyner F Côrtes, Marcelo Martins Sena, Fernão Castro Braga. Definition of chemical markers for Hancornia speciosa Gomes by chemometric analysis based on the chemical composition of extracts, their vasorelaxant effect and α-glucosidase inhibition.
Journal of ethnopharmacology.
2022 Dec; 299(?):115692. doi:
10.1016/j.jep.2022.115692. [PMID: 36084818] - Elif Alan, Gokay Albayrak, Gulnur Sevin, Gunay Yetik-Anacak, Sura Baykan. Relaxation mechanisms of chloroform root extracts of Prangos heyniae and Prangos uechtritzii on mouse corpus cavernosum.
Andrologia.
2022 Dec; 54(11):e14604. doi:
10.1111/and.14604. [PMID: 36163644] - Toshio Kaneda, Farida Ifadotunnikmah, Alfarius Eko Nugroho, Sae Koshikawa, Sasaki Tadahiro, Yusuke Hirasawa, Hiroshi Morita. Calofolic Acid-A from Calophyllum scriblitifolium Bark Has Vasorelaxant Activity via Indirect PKA Activation Caused by PI-3 Kinase Inhibition in Rat Vascular Smooth Muscle Cells.
Journal of natural products.
2022 09; 85(9):2192-2198. doi:
10.1021/acs.jnatprod.2c00502. [PMID: 35983865] - Mouqadus-Un -Nisa, Imran Imran, M Khalid Khan, Amna Shabih, Hassan Ali, Ali M Alqahtani, Taha Alqahtani, Barkat Ali Khan. Pharmacological effects (gastrointestinal, respiratory and vascular) of Calligonum polygonoides: Animal model based studies.
Pakistan journal of pharmaceutical sciences.
2022 Jul; 35(4(Special)):1201-1208. doi:
. [PMID: 36218098] - Iris Lim, Russ Chess-Williams. Mirabegron attenuates porcine ureteral contractility via α1-adrenoceptor antagonism.
Naunyn-Schmiedeberg's archives of pharmacology.
2022 07; 395(7):839-847. doi:
10.1007/s00210-022-02244-0. [PMID: 35445849] - Javier Palacios, Adrián Paredes, Marcelo A Catalán, Chukwuemeka R Nwokocha, Fredi Cifuentes. Novel Oxime Synthesized from a Natural Product of Senecio nutans SCh. Bip. (Asteraceae) Enhances Vascular Relaxation in Rats by an Endothelium-Independent Mechanism.
Molecules (Basel, Switzerland).
2022 May; 27(10):. doi:
10.3390/molecules27103333. [PMID: 35630811] - Dongdong Qian, Jing Tian, Sining Wang, Xiaoli Shan, Pei Zhao, Huihua Chen, Ming Xu, Wei Guo, Chen Zhang, Rong Lu. Trans-cinnamaldehyde protects against phenylephrine-induced cardiomyocyte hypertrophy through the CaMKII/ERK pathway.
BMC complementary medicine and therapies.
2022 Apr; 22(1):115. doi:
10.1186/s12906-022-03594-1. [PMID: 35468773] - Rasha M S M Mohamed, Enssaf Ahmad Ahmad, Bothina H F Omran, Amr T Sakr, Islam A A E-H Ibrahim, Mona F Mahmoud, Mostafa E El-Naggar. Mitigation of dexamethasone-induced nephrotoxicity by modulating the activity of adrenergic receptors: Implication of Wnt/β-arrestin2/β-catenin pathway.
Life sciences.
2022 Mar; 293(?):120304. doi:
10.1016/j.lfs.2022.120304. [PMID: 35016879] - Xu-Xia Li, Peng Zhang, Yang Yang, Jing-Jing Wang, Yan-Jun Zheng, Ji-Liang Tan, Shen-Yan Liu, Yong-Ming Yan, You-Yi Zhang, Yong-Xian Cheng, Huang-Tian Yang. Small molecule QF84139 ameliorates cardiac hypertrophy via activating the AMPK signaling pathway.
Acta pharmacologica Sinica.
2022 Mar; 43(3):588-601. doi:
10.1038/s41401-021-00678-5. [PMID: 33967278] - S-K Park, D-N Park, Y-W Kim, S Yoo, W H Kim, Y-J Lim, J S Park, J K Jun, J-T Kim. Colloid coload versus crystalloid coload to prevent maternal hypotension in women receiving prophylactic phenylephrine infusion during caesarean delivery: a randomised controlled trial.
International journal of obstetric anesthesia.
2022 Feb; 49(?):103246. doi:
10.1016/j.ijoa.2021.103246. [PMID: 35012809] - Joshua M Bock, Kenichi Ueda, Andrew J Feider, Satoshi Hanada, Darren P Casey. Combined inorganic nitrate/nitrite supplementation blunts α-mediated vasoconstriction during exercise in patients with type 2 diabetes.
Nitric oxide : biology and chemistry.
2022 01; 118(?):17-25. doi:
10.1016/j.niox.2021.10.006. [PMID: 34718145] - Kristi Kobluk, Bruno H Pypendop. Effects of dopamine, norepinephrine or phenylephrine on the prevention of hypotension in isoflurane-anesthetized cats administered vatinoxan or vatinoxan and dexmedetomidine.
Veterinary anaesthesia and analgesia.
2022 Jan; 49(1):54-64. doi:
10.1016/j.vaa.2021.11.001. [PMID: 34906421] - Risa Kudo, Katsuya Yuui, Shogo Kasuda. Endothelium-Independent Relaxation of Vascular Smooth Muscle Induced by Persimmon-Derived Polyphenol Phytocomplex in Rats.
Nutrients.
2021 Dec; 14(1):. doi:
10.3390/nu14010089. [PMID: 35010964] - Yao Fu, Nan Hu, Ming Cao, Wen-Feng Li, Xin-Rui Yang, Jin-Lai Gao, Jing Zhao, Man Jiang, Ming-Hui Ma, Zhi-Jie Sun, De-Li Dong. Anthelmintic niclosamide attenuates pressure-overload induced heart failure in mice.
European journal of pharmacology.
2021 Dec; 912(?):174614. doi:
10.1016/j.ejphar.2021.174614. [PMID: 34736968] - Farid Zreik, Reshef Meshulam, Ido Shichel, Muriel Webb, Oren Shibolet, Giris Jacob. Effect of ingesting a meal and orthostasis on the regulation of splanchnic and systemic hemodynamics and the responsiveness of cardiovascular α1-adrenoceptors.
American journal of physiology. Gastrointestinal and liver physiology.
2021 11; 321(5):G513-G526. doi:
10.1152/ajpgi.00142.2021. [PMID: 34523347] - Amandine Bessonnat, Maria Vanore. Effect of topical cyclopentolate alone or combined with phenylephrine in healthy horses.
Veterinary ophthalmology.
2021 Nov; 24(6):582-590. doi:
10.1111/vop.12896. [PMID: 33982406] - Oluwatosin Aisha Oduyemi, Shakiru Ademola Salami, Hussein Mofomosara Salahdeen, Babatunde Adekunle Murtala, Yinusa Raji. Mechanisms of inhibitory activity of root extract of Carpolobia lutea G. Don on in vitro contractile responses of rabbit corpus carvernosum.
Revista internacional de andrologia.
2021 Oct; 19(4):234-241. doi:
10.1016/j.androl.2020.04.003. [PMID: 32593533] - Yana G Toropova, Irina A Zelinskaya, Mariya N Gorshkova, Daria S Motorina, Dmitriy V Korolev, Fedor S Velikonivtsev, Kamil G Gareev. Albumin covering maintains endothelial function upon magnetic iron oxide nanoparticles intravenous injection in rats.
Journal of biomedical materials research. Part A.
2021 10; 109(10):2017-2026. doi:
10.1002/jbm.a.37193. [PMID: 33811797] - Jenny Voggel, Lubomir Lubomirov, Felix Lechner, Gregor Fink, Eva Nüsken, Maria Wohlfarth, Gabriele Pfitzer, Kija Shah-Hosseini, Martin Hellmich, Miguel A Alejandre Alcázar, Jörg Dötsch, Kai-Dietrich Nüsken. Vascular tone regulation in renal interlobar arteries of male rats is dysfunctional after intrauterine growth restriction.
American journal of physiology. Renal physiology.
2021 07; 321(1):F93-F105. doi:
10.1152/ajprenal.00653.2020. [PMID: 34056927] - Nadeem Irshad, Arif-Ullah Khan, Alamgeer, Salah-Ud-Din Khan, Muhammad Shahid Iqbal. Antihypertensive potential of selected pyrimidine derivatives: Explanation of underlying mechanistic pathways.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Jul; 139(?):111567. doi:
10.1016/j.biopha.2021.111567. [PMID: 33848773] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Roeland F Stolk, Flavia Naumann, Eva van der Pasch, Joost Schouwstra, Steffi Bressers, Antonius E van Herwaarden, Jelle Gerretsen, Roel Schambergen, Mike Ruth, Hans G van der Hoeven, Henk J van Leeuwen, Peter Pickkers, Matthijs Kox. Phenylephrine impairs host defence mechanisms to infection: a combined laboratory study in mice and translational human study.
British journal of anaesthesia.
2021 Mar; 126(3):652-664. doi:
10.1016/j.bja.2020.11.040. [PMID: 33483132] - Yukiomi Nakade, Rena Kitano, Taeko Yamauchi, Satoshi Kimoto, Kazumasa Sakamoto, Tadahisa Inoue, Yuji Kobayashi, Tomohiko Ohashi, Yoshio Sumida, Kiyoaki Ito, Masashi Yoneda. Effect of Adrenergic Agonists on High-Fat Diet-Induced Hepatic Steatosis in Mice.
International journal of molecular sciences.
2020 Dec; 21(24):. doi:
10.3390/ijms21249392. [PMID: 33321735] - Baobao Zhang, Xiaolong Hu, Huizhe Wang, Rong Wang, Zhongxuan Sun, Xiaomei Tan, Shumeng Liu, Hao Wang. Effects of a dammarane-type saponin, ginsenoside Rd, in nicotine-induced vascular endothelial injury.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2020 Dec; 79(?):153325. doi:
10.1016/j.phymed.2020.153325. [PMID: 32920289] - Yu G Birulina, V V Ivanov, E E Buyko, E P Efremkina, L V Smagliy, I V Kovalev, A V Nosarev, S V Gusakova. Regulation of Vascular Smooth Muscle Contractions in the Model of Metabolic Syndrome.
Bulletin of experimental biology and medicine.
2020 Dec; 170(2):196-199. doi:
10.1007/s10517-020-05031-0. [PMID: 33263844] - Beth J Allison, Kirsty L Brain, Youguo Niu, Andrew D Kane, Emilio A Herrera, Avnesh S Thakor, Kimberley J Botting, Christine M Cross, Nozomi Itani, Caroline J Shaw, Katie L Skeffington, Chritian Beck, Dino A Giussani. Altered Cardiovascular Defense to Hypotensive Stress in the Chronically Hypoxic Fetus.
Hypertension (Dallas, Tex. : 1979).
2020 10; 76(4):1195-1207. doi:
10.1161/hypertensionaha.120.15384. [PMID: 32862711] - Jiali Zheng, Jing Tian, Sining Wang, Panwei Hu, Qianfu Wu, Xiaoli Shan, Pei Zhao, Chen Zhang, Wei Guo, Ming Xu, Huihua Chen, Rong Lu. Stachydrine hydrochloride suppresses phenylephrine-induced pathological cardiac hypertrophy by inhibiting the calcineurin/nuclear factor of activated T-cell signalling pathway.
European journal of pharmacology.
2020 Sep; 883(?):173386. doi:
10.1016/j.ejphar.2020.173386. [PMID: 32712088] - Wan Yin Tew, Chu Shan Tan, Mohd Zaini Asmawi, Mun Fei Yam. Underlying mechanism of vasorelaxant effect exerted by 3,5,7,2',4'-pentahydroxyflavone in rats aortic ring.
European journal of pharmacology.
2020 Aug; 880(?):173123. doi:
10.1016/j.ejphar.2020.173123. [PMID: 32335091] - Li Li, Yong Wang, Guanglei Chen, Kelly Dong, Haifeng Song. Pre-column derivatization method for determining phenylephrine in human plasma and its application in a pharmacokinetic study.
Biomedical chromatography : BMC.
2020 Aug; 34(8):e4843. doi:
10.1002/bmc.4843. [PMID: 32267540] - Ellis Muggleton, Johannes Janson, Thomas Woodcock. Steady-State Starling Principle remains underappreciated.
Acta anaesthesiologica Scandinavica.
2020 07; 64(6):865. doi:
10.1111/aas.13580. [PMID: 32236949] - Takahiko Kaneko, Tsuneo Tatara, Munetaka Hirose. Response to Muggleton et al.
Acta anaesthesiologica Scandinavica.
2020 07; 64(6):866. doi:
10.1111/aas.13590. [PMID: 32232840] - Zoltan Nemeth, Emily Hildebrandt, Michael J Ryan, Joey P Granger, Heather A Drummond. Pressure-induced constriction of the middle cerebral artery is abolished in TrpC6 knockout mice.
American journal of physiology. Heart and circulatory physiology.
2020 07; 319(1):H42-H50. doi:
10.1152/ajpheart.00126.2020. [PMID: 32412783] - Clement Okraku Tettey, In-Jun Yang, Heung-Mook Shin. Endothelium-dependent vasodilatory effect of Smilax china Linn. water extract via PI3K/Akt signaling.
Archives of physiology and biochemistry.
2020 Jul; 126(3):209-213. doi:
10.1080/13813455.2018.1508237. [PMID: 30269606] - Elizabeth A Swanson, Madhukar S Patel, Tahnee Groat, Nora E Jameson, Margaret K M Ellis, Michael P Hutchens, Claus U Niemann, Darren J Malinoski, Mitchell B Sally. Vasopressor selection during critical care management of brain dead organ donors and the effects on kidney graft function.
The journal of trauma and acute care surgery.
2020 06; 88(6):783-788. doi:
10.1097/ta.0000000000002688. [PMID: 32459446] - Xin Zhao, Xiaotong Wang, Wei Zu, Shichao Chen, Yang Tong, Jidong Liu. An UPLC-MS/MS Method for Simultaneous Determination of Tropicamide and Phenylephrine in Rabbit Ocular Tissues and Plasma.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.
2020 06; 36(5):282-289. doi:
10.1089/jop.2019.0152. [PMID: 32320311] - Kinga Lénárt, Attila Pap, Róbert Pórszász, Anna V Oláh, László Fésüs, András Mádi. Transglutaminase 2 Has Metabolic and Vascular Regulatory Functions Revealed by In Vivo Activation of Alpha1-Adrenergic Receptor.
International journal of molecular sciences.
2020 May; 21(11):. doi:
10.3390/ijms21113865. [PMID: 32485850] - Takahiko Kaneko, Tsuneo Tatara, Munetaka Hirose. Effects of anaesthesia-induced hypotension and phenylephrine on plasma volume expansion by hydroxyethyl starch: A randomised controlled study.
Acta anaesthesiologica Scandinavica.
2020 05; 64(5):620-627. doi:
10.1111/aas.13548. [PMID: 31950482] - Mariana Rosso Melo, Silvia Gasparini, Elaine F Silva, Marlusa Karlen-Amarante, Guilherme F Speretta, Mariana R Lauar, Gustavo R Pedrino, Jose V Menani, Debora S A Colombari, Daniel B Zoccal, Eduardo Colombari. Renovascular hypertension elevates pulmonary ventilation in rats by carotid body-dependent mechanisms.
American journal of physiology. Regulatory, integrative and comparative physiology.
2020 04; 318(4):R730-R742. doi:
10.1152/ajpregu.00134.2019. [PMID: 32022595] - Rui Guo, Ningning Liu, Hao Liu, Junhua Zhang, Han Zhang, Yingchao Wang, Mirko Baruscotti, Lu Zhao, Yi Wang. High content screening identifies licoisoflavone A as a bioactive compound of Tongmaiyangxin Pills to restrain cardiomyocyte hypertrophy via activating Sirt3.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2020 Mar; 68(?):153171. doi:
10.1016/j.phymed.2020.153171. [PMID: 32018211] - Raquel González-Blázquez, Martín Alcalá, María S Fernández-Alfonso, Palmira Villa-Valverde, Marta Viana, Marta Gil-Ortega, Beatriz Somoza. Relevance of control diet choice in metabolic studies: impact in glucose homeostasis and vascular function.
Scientific reports.
2020 02; 10(1):2902. doi:
10.1038/s41598-020-59674-0. [PMID: 32076010] - Benjamin E Rembetski, Kenton M Sanders, Bernard T Drumm. Contribution of Cav1.2 Ca2+ channels and store-operated Ca2+ entry to pig urethral smooth muscle contraction.
American journal of physiology. Renal physiology.
2020 02; 318(2):F496-F505. doi:
10.1152/ajprenal.00514.2019. [PMID: 31904286] - Ahmad Khusairi Azemi, Siti Safiah Mokhtar, Aida Hanum Ghulam Rasool. Clinacanthus nutans Leaves Extract Reverts Endothelial Dysfunction in Type 2 Diabetes Rats by Improving Protein Expression of eNOS.
Oxidative medicine and cellular longevity.
2020; 2020(?):7572892. doi:
10.1155/2020/7572892. [PMID: 32879653] - Chen Braun, Xiaorong Xu Parks, Haani Qudsi, Coeli M Lopes. PKCβII specifically regulates KCNQ1/KCNE1 channel membrane localization.
Journal of molecular and cellular cardiology.
2020 01; 138(?):283-290. doi:
10.1016/j.yjmcc.2019.10.010. [PMID: 31785237] - Cecília R Panta, Éva Ruisanchez, Dorottya Móré, Péter T Dancs, Andrea Balogh, Ágnes Fülöp, Margit Kerék, Richard L Proia, Stefan Offermanns, Gábor J Tigyi, Zoltán Benyó. Sphingosine-1-Phosphate Enhances α1-Adrenergic Vasoconstriction via S1P2-G12/13-ROCK Mediated Signaling.
International journal of molecular sciences.
2019 Dec; 20(24):. doi:
10.3390/ijms20246361. [PMID: 31861195] - William M Armstead, Monica S Vavilala. Cerebral Perfusion Pressure Directed-Therapy Modulates Cardiac Dysfunction After Traumatic Brain Injury to Influence Cerebral Autoregulation in Pigs.
Neurocritical care.
2019 12; 31(3):476-485. doi:
10.1007/s12028-019-00735-2. [PMID: 31115824] - Hongliang Li, Mi Seon Seo, Jin Ryeol An, Hee Seok Jung, Kwon-Soo Ha, Eun-Taek Han, Seok-Ho Hong, Young Min Bae, Sung Hun Na, Won Sun Park. Dipeptidyl peptidase-4 inhibitor sitagliptin induces vasorelaxation via the activation of Kv channels and PKA.
Toxicology and applied pharmacology.
2019 12; 384(?):114799. doi:
10.1016/j.taap.2019.114799. [PMID: 31678606] - Xin-Guo You, Ting-Jun Fan, Guo-Jian Jiang. Phenylephrine induces necroptosis and apoptosis in corneal epithelial cells dose- and time-dependently.
Toxicology.
2019 12; 428(?):152305. doi:
10.1016/j.tox.2019.152305. [PMID: 31605733] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Ming-Ming Qiao, Fei Liu, Yu Liu, Li Guo, Qin-Mei Zhou, Cheng Peng, Liang Xiong. Curcumane C and (±)-curcumane D, an unusual seco-cadinane sesquiterpenoid and a pair of unusual nor-bisabolane enantiomers with significant vasorelaxant activity from Curcuma longa.
Bioorganic chemistry.
2019 11; 92(?):103275. doi:
10.1016/j.bioorg.2019.103275. [PMID: 31539747] - Maria Konstandi, Kyriakos E Kypreos, Tsutomu Matsubara, Eva Xepapadaki, Yatrik M Shah, Kristopher Krausz, Christina E Andriopoulou, Aristeidis Kofinas, Frank J Gonzalez. Adrenoceptor-related decrease in serum triglycerides is independent of PPARα activation.
The FEBS journal.
2019 11; 286(21):4328-4341. doi:
10.1111/febs.14966. [PMID: 31230416] - Rambabu Dakarapu, Ramu Errabelli, Vijaya L Manthati, Adeniyi Michael Adebesin, Deb K Barma, Deepan Barma, Victor Garcia, Fan Zhang, Michal Laniado Schwartzman, John R Falck. 19-Hydroxyeicosatetraenoic acid analogs: Antagonism of 20-hydroxyeicosatetraenoic acid-induced vascular sensitization and hypertension.
Bioorganic & medicinal chemistry letters.
2019 10; 29(19):126616. doi:
10.1016/j.bmcl.2019.08.020. [PMID: 31439380] - Justin D Sprick, Doree L Morison, C Michael Stein, Yunxiao Li, Sachin Paranjape, Ida T Fonkoue, Dana R DaCosta, Jeanie Park. Vascular α1-adrenergic sensitivity is enhanced in chronic kidney disease.
American journal of physiology. Regulatory, integrative and comparative physiology.
2019 09; 317(3):R485-R490. doi:
10.1152/ajpregu.00090.2019. [PMID: 31314543] - Rohit Ramchandra, Daniel T Xing, Marcus Matear, Gavin Lambert, Andrew M Allen, Clive N May. Neurohumoral interactions contributing to renal vasoconstriction and decreased renal blood flow in heart failure.
American journal of physiology. Regulatory, integrative and comparative physiology.
2019 09; 317(3):R386-R396. doi:
10.1152/ajpregu.00026.2019. [PMID: 31241978] - Marwa A A Ragab, Mohamed H Abdel-Hay, Hytham M Ahmed, Sara M Mohyeldin. Determination of Ibuprofen and Phenylephrine in Tablets by High-Performance Thin Layer Chromatography and in Plasma by High-Performance Liquid Chromatography with Diode Array Detection.
Journal of chromatographic science.
2019 Aug; 57(7):592-599. doi:
10.1093/chromsci/bmz031. [PMID: 30994892] - Fernando Romero, Javier Palacios, Ignacio Jofré, Cristian Paz, Chukwuemeka R Nwokocha, Adrián Paredes, Fredi Cifuentes. Aristoteline, an Indole-Alkaloid, Induces Relaxation by Activating Potassium Channels and Blocking Calcium Channels in Isolated Rat Aorta.
Molecules (Basel, Switzerland).
2019 Jul; 24(15):. doi:
10.3390/molecules24152748. [PMID: 31362388] - Hongmei Li, Yun Xing, Duomeng Yang, Xiangxu Tang, Daxiang Lu, Huadong Wang. Alpha-1 Adrenergic Receptor Agonist Phenylephrine Inhibits Sepsis-Induced Cardiomyocyte Apoptosis and Cardiac Dysfunction via Activating ERK1/2 Signal Pathway.
Shock (Augusta, Ga.).
2019 07; 52(1):122-133. doi:
10.1097/shk.0000000000001205. [PMID: 29889817] - Simone R Potje, Marcella D Grando, Andreia Z Chignalia, Cristina Antoniali, Lusiane M Bendhack. Reduced caveolae density in arteries of SHR contributes to endothelial dysfunction and ROS production.
Scientific reports.
2019 04; 9(1):6696. doi:
10.1038/s41598-019-43193-8. [PMID: 31040342] - Leon J DeLalio, Marie Billaud, Claire A Ruddiman, Scott R Johnstone, Joshua T Butcher, Abigail G Wolpe, Xueyao Jin, T C Stevenson Keller, Alexander S Keller, Thibaud Rivière, Miranda E Good, Angela K Best, Alexander W Lohman, Leigh Anne Swayne, Silvia Penuela, Roger J Thompson, Paul D Lampe, Mark Yeager, Brant E Isakson. Constitutive SRC-mediated phosphorylation of pannexin 1 at tyrosine 198 occurs at the plasma membrane.
The Journal of biological chemistry.
2019 04; 294(17):6940-6956. doi:
10.1074/jbc.ra118.006982. [PMID: 30814251] - Hawa Nordin Siti, Yusof Kamisah, Suhaila Mohamed, Kamsiah Jaarin. Effects of citrus leaf extract on aortic vascular reactivity in hypertensive rats fed repeatedly heated vegetable oil.
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.
2019 04; 44(4):373-380. doi:
10.1139/apnm-2018-0175. [PMID: 30216735] - Yomna A Salem, Mohammed E A Hammouda, Mohamed A Abu El-Enin, Saadia M El-Ashry. Application of derivative emission fluorescence spectroscopy for determination of ibuprofen and phenylephrine simultaneously in tablets and biological fluids.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2019 Mar; 210(?):387-397. doi:
10.1016/j.saa.2018.11.054. [PMID: 30503784] - Hong-Mei Li, Kai-Ying Li, Yun Xing, Xiang-Xu Tang, Duo-Meng Yang, Xiao-Meng Dai, Da-Xiang Lu, Hua-Dong Wang. Phenylephrine Attenuated Sepsis-Induced Cardiac Inflammation and Mitochondrial Injury Through an Effect on the PI3K/Akt Signaling Pathway.
Journal of cardiovascular pharmacology.
2019 03; 73(3):186-194. doi:
10.1097/fjc.0000000000000651. [PMID: 30839512] - Chunli Zhu, Siyuan Xu, Xiaopeng Han, Wei Wang, Wei He, Lifang Yin, Lei Yang, Chao Qin. Sustained Release Bilayer Tablet of Ibuprofen and Phenylephrine Hydrochloride: Preparation and Pharmacokinetics in Beagle Dogs.
AAPS PharmSciTech.
2019 Jan; 20(2):86. doi:
10.1208/s12249-018-1271-1. [PMID: 30673916] - Salvatore Smirni, Alison D McNeilly, Michael P MacDonald, Rory J McCrimmon, Faisel Khan. In-vivo correlations between skin metabolic oscillations and vasomotion in wild-type mice and in a model of oxidative stress.
Scientific reports.
2019 01; 9(1):186. doi:
10.1038/s41598-018-36970-4. [PMID: 30655574] - Mi Sun Cheong, Deuk Yeong Lee, Kyung Hye Seo, Geun-Hyoung Choi, Yeong Hun Song, Ki Hun Park, Jin-Hyo Kim. Phenylephrine, a small molecule, inhibits pectin methylesterases.
Biochemical and biophysical research communications.
2019 01; 508(1):320-325. doi:
10.1016/j.bbrc.2018.11.117. [PMID: 30502087] - Maritza Omaña-Molina, Virginia Vanzzini-Zago, Dolores Hernández-Martínez, María Reyes-Batlle, Ismael Castelan-Ramírez, Perla Hernández-Olmos, Lizbeth Salazar-Villatoro, Arturo González-Robles, Elizabeth Ramírez-Flores, Christopher Servín-Flores, Víctor Flores-Alvarado, Marino Alcántara-Castro, Jacob Lorenzo-Morales. Acanthamoeba keratitis in Mexico: Report of a clinical case and importance of sensitivity assays for a better outcome.
Experimental parasitology.
2019 Jan; 196(?):22-27. doi:
10.1016/j.exppara.2018.11.005. [PMID: 30472333] - Robert M Rapoport, Amanda J LeBlanc, Jason E Beare, Manoocher Soleimani. Lack of thiazide diuretic inhibition of agonist constriction of mouse mesenteric arterioles ex vivo.
Naunyn-Schmiedeberg's archives of pharmacology.
2019 01; 392(1):117-121. doi:
10.1007/s00210-018-1590-5. [PMID: 30470918] - Sumei Cui, Yuqian Cui, Yuan Li, Yongtao Zhang, Hao Wang, Weidong Qin, Xiaomei Chen, Shifang Ding, Dawei Wu, Haipeng Guo. Inhibition of cardiac hypertrophy by aromadendrin through down-regulating NFAT and MAPKs pathways.
Biochemical and biophysical research communications.
2018 12; 506(4):805-811. doi:
10.1016/j.bbrc.2018.10.143. [PMID: 30389139] - Guillaume L Hoareau, Harris Kashtan, Lauren E Walker, Carl Beyer, Andrew Wishy, J Kevin Grayson, James D Ross, Ian J Stewart. A Novel Perfusion System for Damage Control of Hyperkalemia in Swine.
Shock (Augusta, Ga.).
2018 12; 50(6):677-683. doi:
10.1097/shk.0000000000001079. [PMID: 30427323] - Fredi Cifuentes, Javier Palacios, Adrián Paredes, Chukwuemeka R Nwokocha, Cristian Paz. 8-Oxo-9-Dihydromakomakine Isolated from Aristotelia chilensis Induces Vasodilation in Rat Aorta: Role of the Extracellular Calcium Influx.
Molecules (Basel, Switzerland).
2018 Nov; 23(11):. doi:
10.3390/molecules23113050. [PMID: 30469451] - Naoko Matsushita, Nanae Ishida, Miho Ibi, Maki Saito, Atsushi Sanbe, Hisashi Shimojo, Satoshi Suzuki, Hermann Koepsell, Yasuchika Takeishi, Yoshihiro Morino, Eiichi Taira, Yohei Sawa, Masamichi Hirose. Chronic Pressure Overload Induces Cardiac Hypertrophy and Fibrosis via Increases in SGLT1 and IL-18 Gene Expression in Mice.
International heart journal.
2018 Sep; 59(5):1123-1133. doi:
10.1536/ihj.17-565. [PMID: 30101852] - Xiao-Yu Liu, Hai-Han Liao, Hong Feng, Nan Zhang, Jing-Jing Yang, Wen-Jing Li, Si Chen, Wei Deng, Qi-Zhu Tang. Icariside II attenuates cardiac remodeling via AMPKα2/mTORC1 in vivo and in vitro.
Journal of pharmacological sciences.
2018 Sep; 138(1):38-45. doi:
10.1016/j.jphs.2018.08.010. [PMID: 30241784] - Leon J DeLalio, Alexander S Keller, Jiwang Chen, Andrew K J Boyce, Mykhaylo V Artamonov, Henry R Askew-Page, T C Stevenson Keller, Scott R Johnstone, Rachel B Weaver, Miranda E Good, Sara A Murphy, Angela K Best, Ellen L Mintz, Silvia Penuela, Iain A Greenwood, Roberto F Machado, Avril V Somlyo, Leigh Anne Swayne, Richard D Minshall, Brant E Isakson. Interaction Between Pannexin 1 and Caveolin-1 in Smooth Muscle Can Regulate Blood Pressure.
Arteriosclerosis, thrombosis, and vascular biology.
2018 09; 38(9):2065-2078. doi:
10.1161/atvbaha.118.311290. [PMID: 30026274] - Sheng-Chang Yang, Ya-Jing Guo, Fu-Yang Yu, Ling-Ling Chen, Wen-Ya Li, En-Sheng Ji. [Bosentan ameliorates hypertension in rats exposed to chronic intermittent hypoxia through inhibiting renal sympathetic nerve activity].
Sheng li xue bao : [Acta physiologica Sinica].
2018 Aug; 70(4):354-360. doi:
NULL. [PMID: 30112560] - Zuheng Liu, Jinghai Hua, Wanqiang Cai, Qiong Zhan, Wenyan Lai, Qingchun Zeng, Hao Ren, Dingli Xu. N‑terminal truncated peroxisome proliferator‑activated receptor‑γ coactivator‑1α alleviates phenylephrine‑induced mitochondrial dysfunction and decreases lipid droplet accumulation in neonatal rat cardiomyocytes.
Molecular medicine reports.
2018 Aug; 18(2):2142-2152. doi:
10.3892/mmr.2018.9158. [PMID: 29901150] - Hui Gao, Hui Liu, Tiexin Tang, Xiaofei Huang, Dongxiu Wang, Yan Li, Pan Huang, Yingfu Peng. Oleanonic acid ameliorates pressure overload-induced cardiac hypertrophy in rats: The role of PKCζ-NF-κB pathway.
Molecular and cellular endocrinology.
2018 07; 470(?):259-268. doi:
10.1016/j.mce.2017.11.007. [PMID: 29138023] - Aline Maria Arlindo de Souza, Crystal A West, Aline Rezende Ribeiro de Abreu, Amrita V Pai, Laura Batista Tavares Mesquita, Hong Ji, Deoclécio Chianca, Rodrigo Cunha Alvim de Menezes, Kathryn Sandberg. Role of the Renin Angiotensin System in Blood Pressure Allostasis-induced by Severe Food Restriction in Female Fischer rats.
Scientific reports.
2018 07; 8(1):10327. doi:
10.1038/s41598-018-28593-6. [PMID: 29985423] - Rui Tan, Yun Jung Lee, Kyung Woo Cho, Dae Gill Kang, Ho Sub Lee. Beneficial Effect of Berberis amurensis Rupr. on Penile Erection.
Chinese journal of integrative medicine.
2018 Jun; 24(6):448-454. doi:
10.1007/s11655-017-2920-z. [PMID: 29335865] - S-H Ok, I-W Shin, S H Lee, J Park, M S Woo, J-M Hong, J Kim, J-T Sohn. Lipid emulsion alleviates the vasodilation and mean blood pressure decrease induced by a toxic dose of verapamil in isolated rat aortae and an in vivo rat model.
Human & experimental toxicology.
2018 Jun; 37(6):636-646. doi:
10.1177/0960327117721963. [PMID: 28741374] - Cathy K Gelotte. An open-label, randomized, four-treatment crossover study evaluating the effects of salt form, acetaminophen, and food on the pharmacokinetics of phenylephrine.
Regulatory toxicology and pharmacology : RTP.
2018 Jun; 95(?):333-338. doi:
10.1016/j.yrtph.2018.04.008. [PMID: 29635061] - Yasuhiro Takenouchi, Kazuo Ohtake, Koji Nobe, Keizo Kasono. Eicosapentaenoic acid ethyl ester improves endothelial dysfunction in type 2 diabetic mice.
Lipids in health and disease.
2018 May; 17(1):118. doi:
10.1186/s12944-018-0770-0. [PMID: 29788974] - Takahisa Suzuki, Atsushi Otsuka, Yoshihiko Ito, Shizuo Yamada, Hideaki Miyake, Seiichiro Ozono. Isosamidin, an extract of Peucedanum japonicum, inhibits phenylephrine-mediated contractions of the human prostate in vitro.
Phytotherapy research : PTR.
2018 May; 32(5):949-952. doi:
10.1002/ptr.6039. [PMID: 29388272] - Xi Han, Yang Liu, Wendy R Kam, David A Sullivan. Effect of brimonidine, an α2 adrenergic agonist, on human meibomian gland epithelial cells.
Experimental eye research.
2018 05; 170(?):20-28. doi:
10.1016/j.exer.2018.02.009. [PMID: 29452108] - Jing Yin, Yu-Ming Guo, Ping Chen, He Xiao, Xing-Huan Wang, Michael E DiSanto, Xin-Hua Zhang. Testosterone regulates the expression and functional activity of sphingosine-1-phosphate receptors in the rat corpus cavernosum.
Journal of cellular and molecular medicine.
2018 03; 22(3):1507-1516. doi:
10.1111/jcmm.13416. [PMID: 29266713] - Seema Bansal, Kanwaljit Chopra. Selective ER-α agonist alleviates vascular endothelial dysfunction in ovariectomized type 2 diabetic rats.
Molecular and cellular endocrinology.
2018 01; 460(?):152-161. doi:
10.1016/j.mce.2017.07.017. [PMID: 28736253] - Tsontcho Ianchulev, Robert Weinreb, James C Tsai, Shan Lin, Louis R Pasquale. High-precision piezo-ejection ocular microdosing: Phase II study on local and systemic effects of topical phenylephrine.
Therapeutic delivery.
2018 Jan; 9(1):17-27. doi:
10.4155/tde-2017-0095. [PMID: 29076771] - Chu Shan Tan, Yean Chun Loh, Chiew Hoong Ng, Yung Sing Ch'ng, Mohd Zaini Asmawi, Mariam Ahmad, Mun Fei Yam. Anti-hypertensive and vasodilatory effects of amended Banxia Baizhu Tianma Tang.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Jan; 97(?):985-994. doi:
10.1016/j.biopha.2017.11.021. [PMID: 29136777] - H Sørensen, J H Thomsen, A S P Meyer, D Terzic, L Hilsted, J Kjærgaard, J P Goetze, T C Barbosa, N H Secher. Phenylephrine increases near-infrared spectroscopy determined muscle oxygenation in men.
Journal of clinical monitoring and computing.
2017 Dec; 31(6):1159-1166. doi:
10.1007/s10877-016-9965-y. [PMID: 27987104] - Danize Aparecida Rizzetti, Ángela Martín, Patricia Corrales, Francisca Fernandez, Maylla Ronacher Simões, Franck Maciel Peçanha, Dalton Valentim Vassallo, Marta Miguel, Giulia Alessandra Wiggers. Egg white-derived peptides prevent cardiovascular disorders induced by mercury in rats: Role of angiotensin-converting enzyme (ACE) and NADPH oxidase.
Toxicology letters.
2017 Nov; 281(?):158-174. doi:
10.1016/j.toxlet.2017.10.001. [PMID: 28987480] - Dante A Suffredini, Yan Li, Wanying Xu, Mahtab Moayeri, Stephen Leppla, Yvonne Fitz, Xizhong Cui, Peter Q Eichacker. Shock and lethality with anthrax edema toxin in rats are associated with reduced arterial responsiveness to phenylephrine and are reversed with adefovir.
American journal of physiology. Heart and circulatory physiology.
2017 Nov; 313(5):H946-H958. doi:
10.1152/ajpheart.00285.2017. [PMID: 28887331] - Michael R Odom, Elena S Pak, David A Brown, Johanna L Hannan. Enhanced Electrical Field Stimulated Nitrergic and Purinergic Vasoreactivity in Distal vs Proximal Internal Pudendal Arteries.
The journal of sexual medicine.
2017 11; 14(11):1285-1296. doi:
10.1016/j.jsxm.2017.09.013. [PMID: 29110801] - K Uerpairojkit, R Anusorntanawat, A Sirisabya, M Chaichalothorn, S Charuluxananan. Neonatal effects after vasopressor during spinal anesthesia for cesarean section: a multicenter, randomized controlled trial.
International journal of obstetric anesthesia.
2017 Nov; 32(?):41-47. doi:
10.1016/j.ijoa.2017.05.009. [PMID: 28689624] - Brian J Anderson, Lisa K Christensen, Valerie E Armstead, David P Bilyeu, Kenneth E Johnson, Robert H Friesen. The phenylephrine concentration-response relationship for blood pressure after nasal delivery in children.
Paediatric anaesthesia.
2017 Oct; 27(10):1050-1055. doi:
10.1111/pan.13221. [PMID: 28868789] - Nina Ashraf-Kashani, John Bell. Haemodynamic changes during hyperthermic intra-thoracic chemotherapy for pseudomyxoma peritonei.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.
2017 09; 33(6):675-678. doi:
10.1080/02656736.2017.1300944. [PMID: 28540781] - Marco Henry Santamaria, Federico Aletti, Joyce B Li, Aaron Tan, Monica Chang, Jessica Leon, Geert W Schmid-Schönbein, Erik B Kistler. Enteral tranexamic acid attenuates vasopressor resistance and changes in α1-adrenergic receptor expression in hemorrhagic shock.
The journal of trauma and acute care surgery.
2017 08; 83(2):263-270. doi:
10.1097/ta.0000000000001513. [PMID: 28422915]