Estradiol (BioDeep_00000002470)

 

Secondary id: BioDeep_00000398254, BioDeep_00000868919

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite BioNovoGene_Lab2019 natural product


代谢物信息卡片


(1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2(7),3,5-triene-5,14-diol

化学式: C18H24O2 (272.1776)
中文名称: 雌二醇
谱图信息: 最多检出来源 Homo sapiens(blood) 9.57%

分子结构信息

SMILES: CC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)O
InChI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3

描述信息

Estradiol is the most potent form of mammalian estrogenic steroids. Estradiol is produced in the ovaries. The ovary requires both luteinizing hormone (LH) and follicle-stimulating hormone (FSH) to produce sex steroids. LH stimulates the cells surrounding the follicle to produce progesterone and androgens. The androgens diffuse across the basement membrane to the granulosa cell layer, where, under the action of FSH, they are aromatized to estrogens, mainly estradiol. The ovary shows cyclical activity, unlike the testis that is maintained in a more or less constant state of activity. Hormone secretions vary according to the phase of the menstrual cycle. In the developing follicle LH receptors (LH-R) are only located on the thecal cells and FSH receptors (FSHR) on the granulosa cells. The dominant pre-ovulatory follicle develops LH-Rs on the granulosa cells prior to the LH surge. Thecal cells of the preovulatory follicle also develop the capacity to synthesize estradiol and this persists when the thecal cells become incorporated into the corpus luteum. After ovulation, the empty follicle is remodelled and plays an important role in the second half or luteal phase of the menstrual cycle. This phase is dominated by progesterone and, to a lesser extent, estradiol secretion by the corpus luteum. estradiol is also synthesized locally from cholesterol through testosterone in the hippocampus and acts rapidly to modulate neuronal synaptic plasticity. Localization of estrogen receptor alpha (ERalpha) in spines in addition to nuclei of principal neurons implies that synaptic ERalpha is responsible for rapid modulation of synaptic plasticity by endogenous estradiol. estradiol is a potent endogenous antioxidant which suppresses hepatic fibrosis in animal models, and attenuates induction of redox sensitive transcription factors, hepatocyte apoptosis and hepatic stellate cells activation by inhibiting a generation of reactive oxygen species in primary cultures. This suggests that the greater progression of hepatic fibrosis and hepatocellular carcinoma in men and postmenopausal women may be due, at least in part, to lower production of estradiol and a reduced response to the action of estradiol. estradiol has been reported to induce the production of interferon (INF)-gamma in lymphocytes, and augments an antigen-specific primary antibody response in human peripheral blood mononuclear cells. IFN-gamma is a potent cytokine with immunomodulatory and antiproliferative properties. Therefore, female subjects, particularly before menopause, may produce antibodies against hepatitis B virus e antigen and hepatitis B virus surface antigen at a higher frequency than males with chronic hepatitis B virus infection. The estradiol-Dihydrotestosterone model of prostate cancer (PC) proposes that the first step in the development of most PC and breast cancer (BC) occurs when aromatase converts testosterone to estradiol. (PMID: 17708600, 17678531, 17644764).
G - Genito urinary system and sex hormones > G03 - Sex hormones and modulators of the genital system > G03C - Estrogens > G03CA - Natural and semisynthetic estrogens, plain
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D004967 - Estrogens
COVID info from COVID-19 Disease Map, clinicaltrial, clinicaltrials, clinical trial, clinical trials
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C483 - Therapeutic Estrogen
Growth promoter for livestock. Permitted in the USA
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Estradiol (β-Estradiol) is a steroid hormone and the major female sex hormone. Estradiol can up-regulate the expression of neural markers of human endometrial stem cells (hEnSCs) and promote their neural differentiation. Estradiol can be used for the research of cancers, neurodegenerative diseases and neural tissue engineering[1][2].
Estradiol (β-Estradiol) is a steroid hormone and the major female sex hormone. Estradiol can up-regulate the expression of neural markers of human endometrial stem cells (hEnSCs) and promote their neural differentiation. Estradiol can be used for the research of cancers, neurodegenerative diseases and neural tissue engineering[1][2].

同义名列表

147 个代谢物同义名

(1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2(7),3,5-triene-5,14-diol; 13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol; Novartis pharmaceuticals brand OF estradiol; 3,17β-Dihydroxy-1,3,5(10)-estratriene; (17beta)-Estra-1,3,5(10)-triene-3,17-diol; Estradiol hemihydrate, (17 alpha)-isomer; 13b-Methyl-1,3,5(10)-gonatriene-3,17b-ol; Estradiol, (8 alpha,17 beta)-(+-)-isomer; 17beta-Estra-1,3,5(10)-triene-3,17-diol; (17b)-Estra-1,3,5(10)-triene-3,17-diol; estra-1,3,5(10)-triene-3,17β-diol; (17Β)-estra-1,3,5(10)-triene-3,17-diol; Estradiol, (16 alpha,17 alpha)-isomer; 3,17b-Dihydroxyestra-1,3,5(10)-triene; 17b-Estra-1,3,5(10)-triene-3,17-diol; 17Β-estra-1,3,5(10)-triene-3,17-diol; Estradiol, (16 alpha,17 beta)-isomer; Estradiol, (9 beta,17 alpha)-isomer; Estradiol, (8 alpha,17 beta)-isomer; Oestra-1,3,5(10)-triene-3,17b-diol; Estradiol, (9 beta,17 beta)-isomer; Estra-1,3,5(10)-triene-3,17b-diol; 1,3,5-Estratriene-3,17β-diol; 3,17-Epidihydroxyestratriene; Estradiol, (17-alpha)-isomer; Estradiol, monosodium salt; Dihydrofollicular hormone; Orion brand OF estradiol; Estradiol, (+-)-isomer; Estradiol, sodium salt; Estradiol monohydrate; ESTRADIOL HEMIHYDRATE; Estradiol orion brand; Estradiol, (-)-isomer; Estring vaginal ring; Estradiol valeriante; (+)-3,17b-Estradiol; Estradiol anhydrous; Estradiol 17 alpha; 17 beta Oestradiol; Estradiol-17 alpha; Estradiol valerate; 17β-Estradiol; 17 beta-Oestradiol; 17beta Oestradiol; Dihydrofolliculin; Estradiol 17 beta; 17 beta Estradiol; 17beta-Oestradiol; Estradiol-17 beta; Estradiol-17-beta; 17 beta-Estradiol; Dihydromenformon; Estradiol 17beta; delta-Oestradiol; Estradiol-17beta; β-estradiol; Dihydro-theelin; 3,17b-Estradiol; Dihydroxyestrin; delta-Estradiol; 17Β-oestradiol; Beta-estradiol; 17Β oestradiol; Dihydrotheelin; 17b-Oestradiol; Progynon depot; 17b Oestradiol; Progynon-depot; Estradiol-17b; Oestroglandol; Estraderm TTS; cis-Estradiol; 17b-Estradiol; Estradiol-17β; Epiestriol 50; D-Oestradiol; Estroclim 50; Estrogel HBF; Follicyclin; D-Estradiol; Delestrogen; Progynon DH; β-Estradiol; b-Estradiol; Amnestrogen; Dimenformon; Profoliol b; Dermestril; Gynoestryl; Estraldine; Oestradiol; Sandrena 1; Perlatanol; Estradiol; Ovahormon; Macrodiol; Compudose; Femestral; Estrovite; Estrasorb; Oestrogel; Ginosedol; Diogynets; Estraderm; Ovasterol; Estroclim; Profoliol; Progynova; Climaderm; Oestergon; Ovastevol; Agofollin; Ovocyclin; Menorest; Estrogel; Progynon; Gelestra; Aerodiol; Primofol; Ovocylin; Estradot; Aquadiol; Corpagen; Gynergon; Nordicol; Innofem; Divigel; Femogen; Syndiol; Lamdiol; Estring; Vivelle; Vagifem; Oesclim; Estrace; Zumenon; Climara; Bardiol; Systen; Diogyn; Evorel; Encore; Altrad; E2; 17β-Estradiol; Estradiol-17beta



数据库引用编号

32 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(14)

BioCyc(0)

PlantCyc(0)

代谢反应

171 个相关的代谢反应过程信息。

Reactome(146)

BioCyc(4)

  • estradiol biosynthesis I: 17β-estradiol + NAD(P)+ ⟶ H+ + NAD(P)H + estrone
  • estradiol biosynthesis II: 19-oxo-testosterone + O2 + a reduced [NADPH-hemoprotein reductase] ⟶ 17β-estradiol + H+ + H2O + an oxidized [NADPH-hemoprotein reductase] + formate
  • estradiol biosynthesis II: 19-oxo-testosterone + O2 + a reduced [NADPH-hemoprotein reductase] ⟶ 17β-estradiol + H+ + H2O + an oxidized [NADPH-hemoprotein reductase] + formate
  • estradiol biosynthesis I (via estrone): O2 + a reduced [NADPH-hemoprotein reductase] + androst-4-ene-3,17-dione ⟶ 19-hydroxyandrostenedione + H2O + an oxidized [NADPH-hemoprotein reductase]

WikiPathways(3)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(18)

PharmGKB(0)

68 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 AFP, ANG, AR, CALCA, CDKN1A, EGFR, NOS3, PIK3C3, POMC
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 2 CD4, EGFR
Cytoplasmic vesicle, autophagosome 1 PIK3C3
Nucleus 8 ANG, AR, CDKN1A, EGFR, IGFBP3, KLK3, NOS3, NR5A1
autophagosome 1 PIK3C3
cytosol 8 ANG, AR, CDKN1A, COMT, NOS3, NR5A1, PIK3C3, PRKCQ
dendrite 1 COMT
nuclear body 1 CDKN1A
phosphatidylinositol 3-kinase complex, class III 1 PIK3C3
nucleoplasm 4 AR, CDKN1A, NOS3, NR5A1
RNA polymerase II transcription regulator complex 1 NR5A1
Cell membrane 3 CD4, COMT, EGFR
ruffle membrane 1 EGFR
Early endosome membrane 1 EGFR
Synapse 2 COMT, CRH
cell junction 1 EGFR
cell surface 1 EGFR
glutamatergic synapse 2 EGFR, PIK3C3
Golgi apparatus 1 NOS3
Golgi membrane 2 EGFR, NOS3
growth cone 1 ANG
lysosomal membrane 1 EGF
neuronal cell body 2 ANG, CALCA
endosome 2 EGFR, PIK3C3
plasma membrane 8 AR, CD4, COMT, EGF, EGFR, KLK3, NOS3, PRKCQ
terminal bouton 1 CALCA
Membrane 5 AR, COMT, EGF, EGFR, PIK3C3
apical plasma membrane 1 EGFR
axon 1 COMT
basolateral plasma membrane 1 EGFR
caveola 1 NOS3
extracellular exosome 4 BMP3, COMT, EGF, KLK3
endoplasmic reticulum 1 CSH1
extracellular space 11 AFP, ANG, BMP3, CALCA, CRH, CSH1, EGF, EGFR, IGFBP3, KLK3, POMC
perinuclear region of cytoplasm 3 CDKN1A, EGFR, NOS3
protein-containing complex 4 AR, CDKN1A, EGFR, KLK3
intracellular membrane-bounded organelle 1 COMT
Single-pass type I membrane protein 2 CD4, EGFR
Secreted 9 AFP, ANG, BMP3, CALCA, CRH, CSH1, IGFBP3, POMC, TRH
extracellular region 10 ANG, BMP3, CALCA, CRH, CSH1, EGF, IGFBP3, KLK3, POMC, TRH
hippocampal mossy fiber to CA3 synapse 1 CALCA
Extracellular side 1 COMT
centriolar satellite 1 PRKCQ
nuclear membrane 1 EGFR
external side of plasma membrane 1 CD4
varicosity 1 CRH
actin cytoskeleton 1 ANG
neuronal dense core vesicle lumen 1 CRH
perikaryon 1 CRH
nucleolus 2 ANG, CDKN1A
midbody 1 PIK3C3
Cytoplasm, P-body 1 NOS3
P-body 1 NOS3
Early endosome 1 CD4
Single-pass type II membrane protein 1 COMT
vesicle 1 CSH1
Membrane raft 2 CD4, EGFR
focal adhesion 1 EGFR
GABA-ergic synapse 1 PIK3C3
Peroxisome 1 PIK3C3
basement membrane 1 ANG
intracellular vesicle 1 EGFR
secretory granule 3 KLK3, POMC, TRH
axoneme 1 PIK3C3
nuclear speck 1 AR
Late endosome 1 PIK3C3
receptor complex 1 EGFR
chromatin 2 AR, NR5A1
phagocytic vesicle membrane 1 PIK3C3
Chromosome 1 ANG
cytoskeleton 1 NOS3
Nucleus, nucleolus 1 ANG
endosome lumen 1 CSH1
phagophore assembly site 1 PIK3C3
phosphatidylinositol 3-kinase complex, class III, type I 1 PIK3C3
phosphatidylinositol 3-kinase complex, class III, type II 1 PIK3C3
Cytoplasm, Stress granule 2 ANG, NOS3
cytoplasmic stress granule 2 ANG, NOS3
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
secretory granule lumen 1 POMC
endoplasmic reticulum lumen 3 AFP, CD4, IGFBP3
platelet alpha granule lumen 1 EGF
endocytic vesicle membrane 1 NOS3
endocytic vesicle 1 ANG
immunological synapse 1 PRKCQ
presynaptic endosome 1 PIK3C3
neuronal dense core vesicle 1 CALCA
aggresome 1 PRKCQ
clathrin-coated endocytic vesicle membrane 3 CD4, EGF, EGFR
cyclin-dependent protein kinase holoenzyme complex 1 CDKN1A
postsynaptic endosome 1 PIK3C3
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
T cell receptor complex 1 CD4
Autolysosome 1 PIK3C3
angiogenin-PRI complex 1 ANG
insulin-like growth factor binding protein complex 1 IGFBP3
insulin-like growth factor ternary complex 1 IGFBP3
PCNA-p21 complex 1 CDKN1A
[Isoform Soluble]: Cytoplasm 1 COMT
[Isoform Membrane-bound]: Cell membrane 1 COMT


文献列表

  • Yumin Chen, Xue Bai, Ying Zhang, Yafang Zhao, Huagen Ma, Yunbo Yang, Meijun Wang, Yinghui Guo, Xiaopeng Li, Tong Wu, Yue Zhang, Hui Kong, Yan Zhao, Huaihua Qu. Zingiberis rhizoma-based carbon dots alter serum oestradiol and follicle-stimulating hormone levels in female mice. Artificial cells, nanomedicine, and biotechnology. 2024 Dec; 52(1):12-22. doi: 10.1080/21691401.2023.2276770. [PMID: 37994799]
  • Zhao Zou, JiaShan Li, Yuan Li, YiBo Yang, PanYu Xu, HanQian Du, Li Guo, ZeHui Li, Na Lin, Ying Xu. UPLC-Triple-TOF-MS-based serum metabonomic revealed the alleviating effect of QingYan Formula on perimenopausal syndrome rats. Journal of pharmaceutical and biomedical analysis. 2024 Aug; 245(?):116166. doi: 10.1016/j.jpba.2024.116166. [PMID: 38669816]
  • Chunlan Liang, Xile Mu, Qinglan Bao, Pengsigerexi Borzigin, Hongyan Sheng, Xiaomei Han, Yingsong Chen, Tegexibaiyin Wang. Exploring the inhibitory impact of Mongolian medicinal He-Zi-3 soup on mammary gland hyperplasia in rats induced by estrogen and progestogen. Journal of ethnopharmacology. 2024 Jul; 329(?):117854. doi: 10.1016/j.jep.2024.117854. [PMID: 38583733]
  • Franca Fruzzetti, Tiziana Fidecicchi, Marco Gambacciani. Oestrogens in oral contraception: considerations for tailoring prescription to women's needs. The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception. 2024 Jun; 29(3):93-102. doi: 10.1080/13625187.2024.2334350. [PMID: 38683756]
  • Leko Bankole Japhet, Gideon Olamilekan Oluwatunase, Tejumade Olubusayo Adejayan. Ethanolic Extract of Xylopia aethiopica Attenuated Aluminum-Induced Ovarian Toxicity in Adult Female Wistar Rats. JBRA assisted reproduction. 2024 Jun; 28(2):284-288. doi: 10.5935/1518-0557.20240024. [PMID: 38640350]
  • Jia-Le Wu, Ze-Hua Liu, Qing-Guang Ma, Yi-Ping Wan, Zhi Dang, Yun Liu, Yu Liu. Combined collection systems of sewage and rainfall runoff seriously affect the spatial distributions of natural estrogens and their conjugates in river water: Insights from the Pearl River of China. Water research. 2024 Jun; 256(?):121588. doi: 10.1016/j.watres.2024.121588. [PMID: 38636120]
  • Shanshan Cao, Mifang Duan, Xuan Zhang, Zhilong Yang, Rui Zhuo. Bacterial community structure analysis of sludge from Taozi lake and isolation of an efficient 17β-Estradiol (E2) degrading strain Sphingobacterium sp. GEMB-CSS-01. Chemosphere. 2024 May; 355(?):141806. doi: 10.1016/j.chemosphere.2024.141806. [PMID: 38548087]
  • Caijie Zheng, Yi Wang, Beilei Bi, Wencheng Zhou, Xinran Cao, Chenyang Zhang, Wentian Lu, Yang Sun, Jiao Qu, Wen Lv. Gallic acid ameliorates endometrial hyperplasia through the inhibition of the PI3K/AKT pathway and the down-regulation of cyclin D1 expression. Journal of pharmacological sciences. 2024 May; 155(1):1-13. doi: 10.1016/j.jphs.2024.02.015. [PMID: 38553133]
  • Chaojin Si, Hongjun Yang, Xiaoyan Wang, Qiaoxin Wang, Min Feng, Huayue Li, Yuqi Feng, Jiayuan Zhao, Ying Liao. Toxic effect and mechanism of β-cypermethrin and its chiral isomers on HTR-8/SVneo cells. Pesticide biochemistry and physiology. 2024 May; 201(?):105849. doi: 10.1016/j.pestbp.2024.105849. [PMID: 38685233]
  • Ségolène Delaitre, Marcel E Visser, Kees van Oers, Samuel P Caro. Odours of caterpillar-infested trees increase testosterone concentrations in male great tits. Hormones and behavior. 2024 Apr; 160(?):105491. doi: 10.1016/j.yhbeh.2024.105491. [PMID: 38340412]
  • Fang Wei, Huifeng Yue, Binjie Wang, Hefa Cheng, Nan Sang. Endocrine disrupting effects of parabens in zebrafish (Danio rerio): New insights from transcriptomics, metabolomics, and molecular dynamics simulation. Chemosphere. 2024 Apr; 354(?):141682. doi: 10.1016/j.chemosphere.2024.141682. [PMID: 38508462]
  • Jordana Georgin, Dison Stracke Pfingsten Franco, Mohammad Saood Manzar, Lucas Meili, Noureddine El Messaoudi. A critical and comprehensive review of the current status of 17β-estradiol hormone remediation through adsorption technology. Environmental science and pollution research international. 2024 Apr; 31(17):24679-24712. doi: 10.1007/s11356-024-32876-z. [PMID: 38488920]
  • Alexander Ciji, M S Akhtar, Priyanka H Tripathi, Maneesh Kumar Dubey, Prakash Sharma. Higher intake of β-glucan impairs reproduction in a female teleost, Tor putitora (Hamilton, 1822). Fish physiology and biochemistry. 2024 Apr; 50(2):589-603. doi: 10.1007/s10695-023-01292-4. [PMID: 38175337]
  • Roy Eerlings, Purvi Gupta, Xiao Yin Lee, Tien Nguyen, Sarah El Kharraz, Florian Handle, Elien Smeets, Lisa Moris, Wout Devlies, Bram Vandewinkel, Irina Thiry, Duy Tien Ta, Anton Gorkovskiy, Karin Voordeckers, Els Henckaerts, Vitor B Pinheiro, Frank Claessens, Kevin J Verstrepen, Arnout Voet, Christine Helsen. Rational evolution for altering the ligand preference of estrogen receptor alpha. Protein science : a publication of the Protein Society. 2024 Apr; 33(4):e4940. doi: 10.1002/pro.4940. [PMID: 38511482]
  • Jiashan Li, Zhao Zou, Xiaohui Su, Panyu Xu, Hanqian Du, Yuan Li, Zehui Li, Li Guo, Na Lin, Ying Xu. Cistanche deserticola improves ovariectomized-induced osteoporosis mainly by regulating lipid metabolism: Insights from serum metabolomics using UPLC/Q-TOF-MS. Journal of ethnopharmacology. 2024 Mar; 322(?):117570. doi: 10.1016/j.jep.2023.117570. [PMID: 38110131]
  • Yuying Zhao, Hanxu Tan, Juping Zhang, Dandan Zhan, Bowen Yang, Shicui Hong, Bo Pan, Neng Wang, Tongkai Chen, Yafei Shi, Zhiyu Wang. Developing liver-targeted naringenin nanoparticles for breast cancer endocrine therapy by promoting estrogen metabolism. Journal of nanobiotechnology. 2024 Mar; 22(1):122. doi: 10.1186/s12951-024-02356-0. [PMID: 38504208]
  • Matthew P Bubak, Shivani N Mann, Agnieszka K Borowik, Atul Pranay, Albert Batushansky, Ivo Vieira de Sousa Neto, Samim A Mondal, Stephen M Doidge, Arik Davidyan, Marcelina M Szczygiel, Frederick F Peelor, Sandra Rigsby, Matle E Broomfield, Charles I Lacy, Heather C Rice, Michael B Stout, Benjamin F Miller. 17α-Estradiol alleviates high-fat diet-induced inflammatory and metabolic dysfunction in skeletal muscle of male and female mice. American journal of physiology. Endocrinology and metabolism. 2024 Mar; 326(3):E226-E244. doi: 10.1152/ajpendo.00215.2023. [PMID: 38197793]
  • Atefeh Nasri, Raimo Pohjanvirta. Comparison of in vitro Toxicities of 8-Prenylnaringenin, Tartrazine and 17β-Estradiol, Representatives of Natural and Synthetic Estrogens, in Rat and Human Hepatoma Cell Lines. Endocrine research. 2024 Feb; 49(2):106-116. doi: 10.1080/07435800.2024.2337758. [PMID: 38597376]
  • Kalpana Baghel, Zaffar Azam, Rashmi Srivastava. Dietary restriction-induced alterations on estrogen receptor alpha expression in regulating fertility in male Coturnix coturnix japonica: Relevance of Withania somnifera in modulation of inflammation and oxidative stress in testis. American journal of reproductive immunology (New York, N.Y. : 1989). 2024 Feb; 91(2):e13816. doi: 10.1111/aji.13816. [PMID: 38414306]
  • Diana Ramírez-Hernández, Pedro López-Sanchez, Diego Lezama-Martínez, Erik Pérez-García, M Fernanda Skat Montoya-Hernández, Alberto Aranda-Fraustro, Jazmin Flores-Monroy. Early Estrogen Replacement Therapy Attenuates Cardiac Dysfunction Caused by Aging and Ovariectomy in Female Wistar Rats. Frontiers in bioscience (Landmark edition). 2024 01; 29(1):46. doi: 10.31083/j.fbl2901046. [PMID: 38287805]
  • Hongyan Jin, Yan Cheng, Fanli Kong, He Huang, Zhenjun Yang, Xinyi Wang, Xinxia Cai, Jinping Luo, Tao Ming. Design and Validation of a Short Novel Estradiol Aptamer and Exploration of Its Application in Sensor Technology. Molecules (Basel, Switzerland). 2024 Jan; 29(2):. doi: 10.3390/molecules29020535. [PMID: 38276613]
  • Kristin H Cochran, Danielle C Westerman, Cassiana C Montagner, Scott Coffin, Lorivic Diaz, Benjamin Fryer, Gary Harraka, Elvis Genbo Xu, Ying Huang, Daniel Schlenk, Dionysios D Dionysiou, Susan D Richardson. Chlorination of Emerging Contaminants for Application in Potable Wastewater Reuse: Disinfection Byproduct Formation, Estrogen Activity, and Cytotoxicity. Environmental science & technology. 2024 Jan; 58(1):704-716. doi: 10.1021/acs.est.3c05978. [PMID: 38109774]
  • Qi-Meng Zhu, Chao Wang, Jing-Wen Liu, Rui Zhang, Xiu-Lan Xin, Juan Zhang, Cheng-Peng Sun, Xiao-Chi Ma. Degradation profile of environmental pollutant 17β-estradiol by human intestinal fungus Aspergillus niger RG13B1 and characterization of genes involved in its degradation. Journal of hazardous materials. 2024 01; 461(?):132617. doi: 10.1016/j.jhazmat.2023.132617. [PMID: 37774607]
  • Kejal Kantarci, Nirubol Tosakulwong, Timothy G Lesnick, Firat Kara, June Kendall-Thomas, Ekta Kapoor, Julie A Fields, Taryn T James, Rogerio A Lobo, JoAnn E Manson, Lubna Pal, Dustin B Hammers, Michael Malek-Ahmadi, Marcelle I Cedars, Frederick N Naftolin, Nanette Santoro, Virginia M Miller, Sherman M Harman, N Maritza Dowling, Carey E Gleason. Cardiometabolic outcomes in Kronos Early Estrogen Prevention Study continuation: 14-year follow-up of a hormone therapy trial. Menopause (New York, N.Y.). 2024 Jan; 31(1):10-17. doi: 10.1097/gme.0000000000002278. [PMID: 37989141]
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  • Qinghai Meng, Ying Chao, Shurui Zhang, Xue Ding, Han Feng, Chenyan Zhang, Bowen Liu, Weijie Zhu, Yu Li, Qichun Zhang, Huangjin Tong, Lixing Wu, Huimin Bian. Attenuation of estrogen and its receptors in the post-menopausal stage exacerbates dyslipidemia and leads to cognitive impairment. Molecular brain. 2023 Nov; 16(1):80. doi: 10.1186/s13041-023-01068-0. [PMID: 37986006]
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