Estradiol (BioDeep_00000002470)
Secondary id: BioDeep_00000398254, BioDeep_00000868919
human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite BioNovoGene_Lab2019 natural product
代谢物信息卡片
化学式: C18H24O2 (272.1776)
中文名称: 雌二醇
谱图信息:
最多检出来源 Homo sapiens(blood) 9.57%
分子结构信息
SMILES: CC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)O
InChI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3
描述信息
Estradiol is the most potent form of mammalian estrogenic steroids. Estradiol is produced in the ovaries. The ovary requires both luteinizing hormone (LH) and follicle-stimulating hormone (FSH) to produce sex steroids. LH stimulates the cells surrounding the follicle to produce progesterone and androgens. The androgens diffuse across the basement membrane to the granulosa cell layer, where, under the action of FSH, they are aromatized to estrogens, mainly estradiol. The ovary shows cyclical activity, unlike the testis that is maintained in a more or less constant state of activity. Hormone secretions vary according to the phase of the menstrual cycle. In the developing follicle LH receptors (LH-R) are only located on the thecal cells and FSH receptors (FSHR) on the granulosa cells. The dominant pre-ovulatory follicle develops LH-Rs on the granulosa cells prior to the LH surge. Thecal cells of the preovulatory follicle also develop the capacity to synthesize estradiol and this persists when the thecal cells become incorporated into the corpus luteum. After ovulation, the empty follicle is remodelled and plays an important role in the second half or luteal phase of the menstrual cycle. This phase is dominated by progesterone and, to a lesser extent, estradiol secretion by the corpus luteum. estradiol is also synthesized locally from cholesterol through testosterone in the hippocampus and acts rapidly to modulate neuronal synaptic plasticity. Localization of estrogen receptor alpha (ERalpha) in spines in addition to nuclei of principal neurons implies that synaptic ERalpha is responsible for rapid modulation of synaptic plasticity by endogenous estradiol. estradiol is a potent endogenous antioxidant which suppresses hepatic fibrosis in animal models, and attenuates induction of redox sensitive transcription factors, hepatocyte apoptosis and hepatic stellate cells activation by inhibiting a generation of reactive oxygen species in primary cultures. This suggests that the greater progression of hepatic fibrosis and hepatocellular carcinoma in men and postmenopausal women may be due, at least in part, to lower production of estradiol and a reduced response to the action of estradiol. estradiol has been reported to induce the production of interferon (INF)-gamma in lymphocytes, and augments an antigen-specific primary antibody response in human peripheral blood mononuclear cells. IFN-gamma is a potent cytokine with immunomodulatory and antiproliferative properties. Therefore, female subjects, particularly before menopause, may produce antibodies against hepatitis B virus e antigen and hepatitis B virus surface antigen at a higher frequency than males with chronic hepatitis B virus infection. The estradiol-Dihydrotestosterone model of prostate cancer (PC) proposes that the first step in the development of most PC and breast cancer (BC) occurs when aromatase converts testosterone to estradiol. (PMID: 17708600, 17678531, 17644764).
G - Genito urinary system and sex hormones > G03 - Sex hormones and modulators of the genital system > G03C - Estrogens > G03CA - Natural and semisynthetic estrogens, plain
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D004967 - Estrogens
COVID info from COVID-19 Disease Map, clinicaltrial, clinicaltrials, clinical trial, clinical trials
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C483 - Therapeutic Estrogen
Growth promoter for livestock. Permitted in the USA
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Estradiol (β-Estradiol) is a steroid hormone and the major female sex hormone. Estradiol can up-regulate the expression of neural markers of human endometrial stem cells (hEnSCs) and promote their neural differentiation. Estradiol can be used for the research of cancers, neurodegenerative diseases and neural tissue engineering[1][2].
Estradiol (β-Estradiol) is a steroid hormone and the major female sex hormone. Estradiol can up-regulate the expression of neural markers of human endometrial stem cells (hEnSCs) and promote their neural differentiation. Estradiol can be used for the research of cancers, neurodegenerative diseases and neural tissue engineering[1][2].
同义名列表
147 个代谢物同义名
(1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2(7),3,5-triene-5,14-diol; 13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol; Novartis pharmaceuticals brand OF estradiol; 3,17β-Dihydroxy-1,3,5(10)-estratriene; (17beta)-Estra-1,3,5(10)-triene-3,17-diol; Estradiol hemihydrate, (17 alpha)-isomer; 13b-Methyl-1,3,5(10)-gonatriene-3,17b-ol; Estradiol, (8 alpha,17 beta)-(+-)-isomer; 17beta-Estra-1,3,5(10)-triene-3,17-diol; (17b)-Estra-1,3,5(10)-triene-3,17-diol; estra-1,3,5(10)-triene-3,17β-diol; (17Β)-estra-1,3,5(10)-triene-3,17-diol; Estradiol, (16 alpha,17 alpha)-isomer; 3,17b-Dihydroxyestra-1,3,5(10)-triene; 17b-Estra-1,3,5(10)-triene-3,17-diol; 17Β-estra-1,3,5(10)-triene-3,17-diol; Estradiol, (16 alpha,17 beta)-isomer; Estradiol, (9 beta,17 alpha)-isomer; Estradiol, (8 alpha,17 beta)-isomer; Oestra-1,3,5(10)-triene-3,17b-diol; Estradiol, (9 beta,17 beta)-isomer; Estra-1,3,5(10)-triene-3,17b-diol; 1,3,5-Estratriene-3,17β-diol; 3,17-Epidihydroxyestratriene; Estradiol, (17-alpha)-isomer; Estradiol, monosodium salt; Dihydrofollicular hormone; Orion brand OF estradiol; Estradiol, (+-)-isomer; Estradiol, sodium salt; Estradiol monohydrate; ESTRADIOL HEMIHYDRATE; Estradiol orion brand; Estradiol, (-)-isomer; Estring vaginal ring; Estradiol valeriante; (+)-3,17b-Estradiol; Estradiol anhydrous; Estradiol 17 alpha; 17 beta Oestradiol; Estradiol-17 alpha; Estradiol valerate; 17β-Estradiol; 17 beta-Oestradiol; 17beta Oestradiol; Dihydrofolliculin; Estradiol 17 beta; 17 beta Estradiol; 17beta-Oestradiol; Estradiol-17 beta; Estradiol-17-beta; 17 beta-Estradiol; Dihydromenformon; Estradiol 17beta; delta-Oestradiol; Estradiol-17beta; β-estradiol; Dihydro-theelin; 3,17b-Estradiol; Dihydroxyestrin; delta-Estradiol; 17Β-oestradiol; Beta-estradiol; 17Β oestradiol; Dihydrotheelin; 17b-Oestradiol; Progynon depot; 17b Oestradiol; Progynon-depot; Estradiol-17b; Oestroglandol; Estraderm TTS; cis-Estradiol; 17b-Estradiol; Estradiol-17β; Epiestriol 50; D-Oestradiol; Estroclim 50; Estrogel HBF; Follicyclin; D-Estradiol; Delestrogen; Progynon DH; β-Estradiol; b-Estradiol; Amnestrogen; Dimenformon; Profoliol b; Dermestril; Gynoestryl; Estraldine; Oestradiol; Sandrena 1; Perlatanol; Estradiol; Ovahormon; Macrodiol; Compudose; Femestral; Estrovite; Estrasorb; Oestrogel; Ginosedol; Diogynets; Estraderm; Ovasterol; Estroclim; Profoliol; Progynova; Climaderm; Oestergon; Ovastevol; Agofollin; Ovocyclin; Menorest; Estrogel; Progynon; Gelestra; Aerodiol; Primofol; Ovocylin; Estradot; Aquadiol; Corpagen; Gynergon; Nordicol; Innofem; Divigel; Femogen; Syndiol; Lamdiol; Estring; Vivelle; Vagifem; Oesclim; Estrace; Zumenon; Climara; Bardiol; Systen; Diogyn; Evorel; Encore; Altrad; E2; 17β-Estradiol; Estradiol-17beta
数据库引用编号
32 个数据库交叉引用编号
- ChEBI: CHEBI:16469
- ChEBI: CHEBI:95191
- KEGG: C00951
- KEGGdrug: D00105
- PubChem: 5757
- PubChem: 450
- HMDB: HMDB0000151
- Metlin: METLIN263
- DrugBank: DB00783
- ChEMBL: CHEMBL412
- ChEMBL: CHEMBL135
- Wikipedia: Estradiol
- MeSH: Estradiol
- foodb: FDB000362
- chemspider: 5554
- CAS: 1093411-48-3
- CAS: 141290-02-0
- CAS: 17916-67-5
- CAS: 5864-38-0
- CAS: 50-28-2
- PMhub: MS000002747
- PubChem: 4202
- LipidMAPS: LMST02010001
- PDB-CCD: EST
- 3DMET: B01357
- NIKKAJI: J4.100I
- RefMet: beta-Estradiol
- medchemexpress: HY-B0141
- BioNovoGene_Lab2019: BioNovoGene_Lab2019-967
- KNApSAcK: 16469
- LOTUS: LTS0165831
- LOTUS: LTS0134723
分类词条
相关代谢途径
Reactome(14)
- Metabolism
- Biological oxidations
- Phase I - Functionalization of compounds
- Disease
- Phase II - Conjugation of compounds
- Cytosolic sulfonation of small molecules
- Metabolism of lipids
- Metabolism of steroids
- Diseases of metabolism
- Cytochrome P450 - arranged by substrate type
- Endogenous sterols
- Metabolic disorders of biological oxidation enzymes
- Metabolism of steroid hormones
- Estrogen biosynthesis
BioCyc(0)
PlantCyc(0)
代谢反应
171 个相关的代谢反应过程信息。
Reactome(146)
- Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA
- Metabolism of lipids:
H+ + LTHSOL + Oxygen + TPNH ⟶ 7-dehydroCHOL + H2O + TPN
- Metabolism of steroids:
H+ + LTHSOL + Oxygen + TPNH ⟶ 7-dehydroCHOL + H2O + TPN
- Metabolism of steroid hormones:
H+ + TPNH + estrone ⟶ EST17b + TPN
- Estrogen biosynthesis:
H+ + TPNH + estrone ⟶ EST17b + TPN
- Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA
- Metabolism of lipids:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA
- Metabolism of steroids:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA
- Metabolism of steroid hormones:
17aHPROG + H+ + Oxygen + TPNH ⟶ 11-deoxycortisol + H2O + TPN
- Estrogen biosynthesis:
H+ + Oxygen + TEST + TPNH ⟶ EST17b + H2O + HCOOH + TPN
- Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN
- Phase I - Functionalization of compounds:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN
- Cytochrome P450 - arranged by substrate type:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN
- Endogenous sterols:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN
- Phase II - Conjugation of compounds:
H2O + PNPB ⟶ BUT + PNP
- Cytosolic sulfonation of small molecules:
H2O + PNPB ⟶ BUT + PNP
- Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA
- Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA
- Metabolism of steroids:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA
- Metabolism of steroid hormones:
H+ + Oxygen + TEST + TPNH ⟶ EST17b + H2O + HCOOH + TPN
- Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA
- Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA
- Metabolism of steroids:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA
- Metabolism of steroid hormones:
17aHPROG + H+ + Oxygen + TPNH ⟶ 11-deoxycortisol + H2O + TPN
- Estrogen biosynthesis:
H+ + TPNH + estrone ⟶ EST17b + TPN
- Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN
- Phase I - Functionalization of compounds:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN
- Cytochrome P450 - arranged by substrate type:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN
- Endogenous sterols:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN
- Phase II - Conjugation of compounds:
H2O + PNPB ⟶ BUT + PNP
- Cytosolic sulfonation of small molecules:
H2O + PNPB ⟶ BUT + PNP
- Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA
- Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA
- Metabolism of steroids:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA
- Metabolism of steroid hormones:
17aHPROG + H+ + Oxygen + TPNH ⟶ 11-deoxycortisol + H2O + TPN
- Estrogen biosynthesis:
H+ + Oxygen + TEST + TPNH ⟶ EST17b + H2O + HCOOH + TPN
- Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN
- Phase I - Functionalization of compounds:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN
- Cytochrome P450 - arranged by substrate type:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN
- Endogenous sterols:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN
- Phase II - Conjugation of compounds:
H2O + PNPB ⟶ BUT + PNP
- Cytosolic sulfonation of small molecules:
H2O + PNPB ⟶ BUT + PNP
- Metabolism:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi
- Metabolism of lipids:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi
- Metabolism of steroids:
H+ + TPNH + estrone ⟶ EST17b + TPN
- Metabolism of steroid hormones:
H+ + TPNH + estrone ⟶ EST17b + TPN
- Estrogen biosynthesis:
H+ + TPNH + estrone ⟶ EST17b + TPN
- Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA
- Metabolism of lipids:
3-oxopristanoyl-CoA + CoA-SH ⟶ 4,8,12-trimethyltridecanoyl-CoA + propionyl CoA
- Metabolism of steroids:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA
- Metabolism of steroid hormones:
H+ + Oxygen + TEST + TPNH ⟶ EST17b + H2O + HCOOH + TPN
- Estrogen biosynthesis:
H+ + Oxygen + TEST + TPNH ⟶ EST17b + H2O + HCOOH + TPN
- Biological oxidations:
CH3CHO + H2O + NAD ⟶ CH3COO- + H+ + NADH
- Phase II - Conjugation of compounds:
H2O + SAH ⟶ Ade-Rib + HCYS
- Cytosolic sulfonation of small molecules:
H2O + PAP ⟶ AMP + Pi
- Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA
- Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA
- Metabolism of steroids:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA
- Metabolism of steroid hormones:
17aHPROG + H+ + Oxygen + TPNH ⟶ 11-deoxycortisol + H2O + TPN
- Estrogen biosynthesis:
H+ + Oxygen + TEST + TPNH ⟶ EST17b + H2O + HCOOH + TPN
- Biological oxidations:
H+ + Oxygen + TPNH + progesterone ⟶ 11DCORST + H2O + TPN
- Phase I - Functionalization of compounds:
H+ + Oxygen + TPNH + progesterone ⟶ 11DCORST + H2O + TPN
- Cytochrome P450 - arranged by substrate type:
H+ + Oxygen + TPNH + progesterone ⟶ 11DCORST + H2O + TPN
- Endogenous sterols:
H+ + Oxygen + TPNH + progesterone ⟶ 11DCORST + H2O + TPN
- Phase II - Conjugation of compounds:
H2O + PNPB ⟶ BUT + PNP
- Cytosolic sulfonation of small molecules:
H2O + PNPB ⟶ BUT + PNP
- Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA
- Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA
- Metabolism of steroids:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA
- Metabolism of steroid hormones:
11-deoxycortisol ⟶ 11DCORT
- Estrogen biosynthesis:
H+ + Oxygen + TEST + TPNH ⟶ EST17b + H2O + HCOOH + TPN
- Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN
- Phase I - Functionalization of compounds:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN
- Cytochrome P450 - arranged by substrate type:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN
- Endogenous sterols:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN
- Phase II - Conjugation of compounds:
H2O + PNPB ⟶ BUT + PNP
- Cytosolic sulfonation of small molecules:
H2O + PNPB ⟶ BUT + PNP
- Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA
- Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA
- Metabolism of steroids:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA
- Metabolism of steroid hormones:
17aHPROG + H+ + Oxygen + TPNH ⟶ 11-deoxycortisol + H2O + TPN
- Estrogen biosynthesis:
H+ + Oxygen + TEST + TPNH ⟶ EST17b + H2O + HCOOH + TPN
- Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN
- Phase I - Functionalization of compounds:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN
- Cytochrome P450 - arranged by substrate type:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN
- Endogenous sterols:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN
- Phase II - Conjugation of compounds:
H2O + PNPB ⟶ BUT + PNP
- Cytosolic sulfonation of small molecules:
H2O + PNPB ⟶ BUT + PNP
- Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA
- Metabolism of lipids:
H+ + LTHSOL + Oxygen + TPNH ⟶ 7-dehydroCHOL + H2O + TPN
- Metabolism of steroids:
H+ + LTHSOL + Oxygen + TPNH ⟶ 7-dehydroCHOL + H2O + TPN
- Metabolism of steroid hormones:
H+ + Oxygen + TEST + TPNH ⟶ EST17b + H2O + HCOOH + TPN
- Estrogen biosynthesis:
H+ + Oxygen + TEST + TPNH ⟶ EST17b + H2O + HCOOH + TPN
- Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA
- Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA
- Metabolism of steroids:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA
- Metabolism of steroid hormones:
17aHPROG + H+ + Oxygen + TPNH ⟶ 11-deoxycortisol + H2O + TPN
- Estrogen biosynthesis:
H+ + Oxygen + TEST + TPNH ⟶ EST17b + H2O + HCOOH + TPN
- Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN
- Phase I - Functionalization of compounds:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN
- Cytochrome P450 - arranged by substrate type:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN
- Endogenous sterols:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN
- Phase II - Conjugation of compounds:
H2O + PNPB ⟶ BUT + PNP
- Cytosolic sulfonation of small molecules:
H2O + PNPB ⟶ BUT + PNP
- Metabolism:
CAR + propionyl CoA ⟶ CoA-SH + Propionylcarnitine
- Metabolism of lipids:
CAR + propionyl CoA ⟶ CoA-SH + Propionylcarnitine
- Metabolism of steroids:
H+ + LTHSOL + Oxygen + TPNH ⟶ 7-dehydroCHOL + H2O + TPN
- Metabolism of steroid hormones:
EST17b + TPN ⟶ H+ + TPNH + estrone
- Estrogen biosynthesis:
EST17b + TPN ⟶ H+ + TPNH + estrone
- Metabolism:
GAA + SAM ⟶ CRET + H+ + SAH
- Metabolism of lipids:
ACA + H+ + NADH ⟶ NAD + bHBA
- Metabolism of steroids:
H+ + LTHSOL + Oxygen + TPNH ⟶ 7-dehydroCHOL + H2O + TPN
- Metabolism of steroid hormones:
H+ + TPNH + estrone ⟶ EST17b + TPN
- Estrogen biosynthesis:
H+ + TPNH + estrone ⟶ EST17b + TPN
- Metabolism:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi
- Metabolism of lipids:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi
- Metabolism of steroids:
17aHPROG + H+ + Oxygen + TPNH ⟶ 11-deoxycortisol + H2O + TPN
- Metabolism of steroid hormones:
17aHPROG + H+ + Oxygen + TPNH ⟶ 11-deoxycortisol + H2O + TPN
- Estrogen biosynthesis:
EST17b + TPN ⟶ H+ + TPNH + estrone
- Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN
- Phase I - Functionalization of compounds:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN
- Cytochrome P450 - arranged by substrate type:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN
- Endogenous sterols:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN
- Phase II - Conjugation of compounds:
PAPS + beta-estradiol ⟶ E2-SO4 + PAP
- Cytosolic sulfonation of small molecules:
PAPS + beta-estradiol ⟶ E2-SO4 + PAP
- Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA
- Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA
- Metabolism of steroids:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA
- Metabolism of steroid hormones:
H+ + Oxygen + TEST + TPNH ⟶ EST17b + H2O + HCOOH + TPN
- Estrogen biosynthesis:
H+ + Oxygen + TEST + TPNH ⟶ EST17b + H2O + HCOOH + TPN
- Biological oxidations:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ AFXBO + H2O + TPN
- Phase I - Functionalization of compounds:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ AFXBO + H2O + TPN
- Cytochrome P450 - arranged by substrate type:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ AFXBO + H2O + TPN
- Endogenous sterols:
EST17b + H+ + Oxygen + TPNH ⟶ 4OH-EST17b + H2O + TPN
- Phase II - Conjugation of compounds:
H2O + PNPB ⟶ BUT + PNP
- Cytosolic sulfonation of small molecules:
H2O + PNPB ⟶ BUT + PNP
- Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA
- Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA
- Metabolism of steroids:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA
- Metabolism of steroid hormones:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN
- Estrogen biosynthesis:
H+ + Oxygen + TEST + TPNH ⟶ EST17b + H2O + HCOOH + TPN
- Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN
- Phase II - Conjugation of compounds:
H2O + PNPB ⟶ BUT + PNP
- Cytosolic sulfonation of small molecules:
H2O + PNPB ⟶ BUT + PNP
- Estrogen biosynthesis:
H+ + Oxygen + TEST + TPNH ⟶ EST17b + H2O + HCOOH + TPN
- Estrogen biosynthesis:
EST17b + TPN ⟶ H+ + TPNH + estrone
BioCyc(4)
- estradiol biosynthesis I:
17β-estradiol + NAD(P)+ ⟶ H+ + NAD(P)H + estrone
- estradiol biosynthesis II:
19-oxo-testosterone + O2 + a reduced [NADPH-hemoprotein reductase] ⟶ 17β-estradiol + H+ + H2O + an oxidized [NADPH-hemoprotein reductase] + formate
- estradiol biosynthesis II:
19-oxo-testosterone + O2 + a reduced [NADPH-hemoprotein reductase] ⟶ 17β-estradiol + H+ + H2O + an oxidized [NADPH-hemoprotein reductase] + formate
- estradiol biosynthesis I (via estrone):
O2 + a reduced [NADPH-hemoprotein reductase] + androst-4-ene-3,17-dione ⟶ 19-hydroxyandrostenedione + H2O + an oxidized [NADPH-hemoprotein reductase]
WikiPathways(3)
- Estrogen metabolism:
2-Methoxyestradiol ⟶ 2-methoxy-17beta-estradiol 3-glucuronide
- Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism:
11-Deoxycortisol ⟶ Cortisol
- Sulfatase and aromatase pathway:
DHEA ⟶ Androstenedione
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(18)
- Estrone Metabolism:
2-Hydroxyestrone + S-Adenosylmethionine ⟶ 2-Methoxyestrone + S-Adenosylhomocysteine
- Estrone Metabolism:
2-Hydroxyestrone + S-Adenosylmethionine ⟶ 2-Methoxyestrone + S-Adenosylhomocysteine
- Estrone Metabolism:
2-Hydroxyestrone + S-Adenosylmethionine ⟶ 2-Methoxyestrone + S-Adenosylhomocysteine
- Estrone Metabolism:
2-Hydroxyestrone + S-Adenosylmethionine ⟶ 2-Methoxyestrone + S-Adenosylhomocysteine
- Estrone Metabolism:
2-Hydroxyestrone + S-Adenosylmethionine ⟶ 2-Methoxyestrone + S-Adenosylhomocysteine
- Estrone Metabolism:
2-Hydroxyestrone + S-Adenosylmethionine ⟶ 2-Methoxyestrone + S-Adenosylhomocysteine
- Androgen and Estrogen Metabolism:
Estradiol + NADP ⟶ Estrone + NADPH
- 17-beta Hydroxysteroid Dehydrogenase III Deficiency:
Estradiol + NADP ⟶ Estrone + NADPH
- Aromatase Deficiency:
Estradiol + NADP ⟶ Estrone + NADPH
- Androgen and Estrogen Metabolism:
Estradiol + NADP ⟶ Estrone + NADPH
- 17-beta Hydroxysteroid Dehydrogenase III Deficiency:
Estradiol + NADP ⟶ Estrone + NADPH
- Aromatase Deficiency:
Estradiol + NADP ⟶ Estrone + NADPH
- Androgen and Estrogen Metabolism:
Estradiol + NADP ⟶ Estrone + NADPH
- Androgen and Estrogen Metabolism:
Estradiol + NADP ⟶ Estrone + NADPH
- Androgen and Estrogen Metabolism:
Estradiol + NADP ⟶ Estrone + NADPH
- Androgen and Estrogen Metabolism:
Estradiol + NADP ⟶ Estrone + NADPH
- 17-beta Hydroxysteroid Dehydrogenase III Deficiency:
Estradiol + NADP ⟶ Estrone + NADPH
- Aromatase Deficiency:
Estradiol + NADP ⟶ Estrone + NADPH
PharmGKB(0)
68 个相关的物种来源信息
- 7002 - Acrididae: LTS0165831
- 654 - Aeromonas veronii: 10.3389/FCIMB.2020.00044
- 6656 - Arthropoda: LTS0134723
- 6656 - Arthropoda: LTS0165831
- 7604 - Asterias rubens: 10.1016/0305-0491(92)90151-G
- 6658 - Branchiopoda: LTS0165831
- 9863 - Cervus nippon , Cervus elaphus: -
- 7711 - Chordata: LTS0165831
- 53862 - Dalbergia: LTS0165831
- 107308 - Dalbergia sissoo: 10.1016/J.BMCL.2011.12.036
- 107308 - Dalbergia sissoo: LTS0165831
- 6668 - Daphnia: LTS0165831
- 35525 - Daphnia magna: 10.1006/EESA.1999.1859
- 35525 - Daphnia magna: LTS0165831
- 77658 - Daphniidae: LTS0165831
- 50515 - Dytiscidae: LTS0134723
- 3039 - Euglena gracilis: 10.3389/FBIOE.2021.662655
- 2759 - Eukaryota: LTS0134723
- 2759 - Eukaryota: LTS0165831
- 3803 - Fabaceae: LTS0165831
- 9604 - Hominidae: LTS0165831
- 9605 - Homo: LTS0165831
- 9606 - Homo sapiens:
- 9606 - Homo sapiens: -
- 9606 - Homo sapiens: 10.1038/NBT.2488
- 9606 - Homo sapiens: LTS0165831
- 156912 - Ilybius: LTS0134723
- 156954 - Ilybius fenestratus: 10.1002/CBER.19691020610
- 156954 - Ilybius fenestratus: LTS0134723
- 50557 - Insecta: LTS0134723
- 50557 - Insecta: LTS0165831
- 7003 - Locusta: LTS0165831
- 7004 - Locusta migratoria: 10.1016/0305-0491(92)90052-S
- 7004 - Locusta migratoria: LTS0165831
- 3928 - Lythraceae: LTS0134723
- 3398 - Magnoliopsida: LTS0134723
- 3398 - Magnoliopsida: LTS0165831
- 40674 - Mammalia: LTS0165831
- 33208 - Metazoa: LTS0134723
- 33208 - Metazoa: LTS0165831
- 10066 - Muridae: LTS0165831
- 10088 - Mus: LTS0165831
- 10090 - Mus musculus: LTS0165831
- 10090 - Mus musculus: NA
- 13171 - Neobellieria: LTS0165831
- 3881 - Onobrychis: LTS0165831
- 3021493 - Onobrychis ebenoides: LTS0165831
- 3754 - Prunus: LTS0134723
- 36596 - Prunus armeniaca: 10.1016/S0031-9422(00)91390-6
- 36596 - Prunus armeniaca: LTS0134723
- 22662 - Punica: LTS0134723
- 22663 - Punica granatum: 10.3109/07435800903524161
- 22663 - Punica granatum: LTS0134723
- 3745 - Rosaceae: LTS0134723
- 7384 - Sarcophaga: LTS0165831
- 7385 - Sarcophaga bullata: 10.1007/BF01946450
- 7385 - Sarcophaga bullata: LTS0165831
- 7381 - Sarcophagidae: LTS0165831
- 4070 - Solanaceae: LTS0165831
- 4107 - Solanum: LTS0165831
- 52877 - Solanum glaucophyllum: 10.1006/BBRC.2001.6079
- 52877 - Solanum glaucophyllum: LTS0165831
- 35493 - Streptophyta: LTS0134723
- 35493 - Streptophyta: LTS0165831
- 58023 - Tracheophyta: LTS0134723
- 58023 - Tracheophyta: LTS0165831
- 33090 - Viridiplantae: LTS0134723
- 33090 - Viridiplantae: LTS0165831
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Yumin Chen, Xue Bai, Ying Zhang, Yafang Zhao, Huagen Ma, Yunbo Yang, Meijun Wang, Yinghui Guo, Xiaopeng Li, Tong Wu, Yue Zhang, Hui Kong, Yan Zhao, Huaihua Qu. Zingiberis rhizoma-based carbon dots alter serum oestradiol and follicle-stimulating hormone levels in female mice.
Artificial cells, nanomedicine, and biotechnology.
2024 Dec; 52(1):12-22. doi:
10.1080/21691401.2023.2276770
. [PMID: 37994799] - Zhao Zou, JiaShan Li, Yuan Li, YiBo Yang, PanYu Xu, HanQian Du, Li Guo, ZeHui Li, Na Lin, Ying Xu. UPLC-Triple-TOF-MS-based serum metabonomic revealed the alleviating effect of QingYan Formula on perimenopausal syndrome rats.
Journal of pharmaceutical and biomedical analysis.
2024 Aug; 245(?):116166. doi:
10.1016/j.jpba.2024.116166
. [PMID: 38669816] - Chunlan Liang, Xile Mu, Qinglan Bao, Pengsigerexi Borzigin, Hongyan Sheng, Xiaomei Han, Yingsong Chen, Tegexibaiyin Wang. Exploring the inhibitory impact of Mongolian medicinal He-Zi-3 soup on mammary gland hyperplasia in rats induced by estrogen and progestogen.
Journal of ethnopharmacology.
2024 Jul; 329(?):117854. doi:
10.1016/j.jep.2024.117854
. [PMID: 38583733] - Franca Fruzzetti, Tiziana Fidecicchi, Marco Gambacciani. Oestrogens in oral contraception: considerations for tailoring prescription to women's needs.
The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception.
2024 Jun; 29(3):93-102. doi:
10.1080/13625187.2024.2334350
. [PMID: 38683756] - Leko Bankole Japhet, Gideon Olamilekan Oluwatunase, Tejumade Olubusayo Adejayan. Ethanolic Extract of Xylopia aethiopica Attenuated Aluminum-Induced Ovarian Toxicity in Adult Female Wistar Rats.
JBRA assisted reproduction.
2024 Jun; 28(2):284-288. doi:
10.5935/1518-0557.20240024
. [PMID: 38640350] - Jia-Le Wu, Ze-Hua Liu, Qing-Guang Ma, Yi-Ping Wan, Zhi Dang, Yun Liu, Yu Liu. Combined collection systems of sewage and rainfall runoff seriously affect the spatial distributions of natural estrogens and their conjugates in river water: Insights from the Pearl River of China.
Water research.
2024 Jun; 256(?):121588. doi:
10.1016/j.watres.2024.121588
. [PMID: 38636120] - Shanshan Cao, Mifang Duan, Xuan Zhang, Zhilong Yang, Rui Zhuo. Bacterial community structure analysis of sludge from Taozi lake and isolation of an efficient 17β-Estradiol (E2) degrading strain Sphingobacterium sp. GEMB-CSS-01.
Chemosphere.
2024 May; 355(?):141806. doi:
10.1016/j.chemosphere.2024.141806
. [PMID: 38548087] - Caijie Zheng, Yi Wang, Beilei Bi, Wencheng Zhou, Xinran Cao, Chenyang Zhang, Wentian Lu, Yang Sun, Jiao Qu, Wen Lv. Gallic acid ameliorates endometrial hyperplasia through the inhibition of the PI3K/AKT pathway and the down-regulation of cyclin D1 expression.
Journal of pharmacological sciences.
2024 May; 155(1):1-13. doi:
10.1016/j.jphs.2024.02.015
. [PMID: 38553133] - Chaojin Si, Hongjun Yang, Xiaoyan Wang, Qiaoxin Wang, Min Feng, Huayue Li, Yuqi Feng, Jiayuan Zhao, Ying Liao. Toxic effect and mechanism of β-cypermethrin and its chiral isomers on HTR-8/SVneo cells.
Pesticide biochemistry and physiology.
2024 May; 201(?):105849. doi:
10.1016/j.pestbp.2024.105849
. [PMID: 38685233] - Ségolène Delaitre, Marcel E Visser, Kees van Oers, Samuel P Caro. Odours of caterpillar-infested trees increase testosterone concentrations in male great tits.
Hormones and behavior.
2024 Apr; 160(?):105491. doi:
10.1016/j.yhbeh.2024.105491
. [PMID: 38340412] - Fang Wei, Huifeng Yue, Binjie Wang, Hefa Cheng, Nan Sang. Endocrine disrupting effects of parabens in zebrafish (Danio rerio): New insights from transcriptomics, metabolomics, and molecular dynamics simulation.
Chemosphere.
2024 Apr; 354(?):141682. doi:
10.1016/j.chemosphere.2024.141682
. [PMID: 38508462] - Jordana Georgin, Dison Stracke Pfingsten Franco, Mohammad Saood Manzar, Lucas Meili, Noureddine El Messaoudi. A critical and comprehensive review of the current status of 17β-estradiol hormone remediation through adsorption technology.
Environmental science and pollution research international.
2024 Apr; 31(17):24679-24712. doi:
10.1007/s11356-024-32876-z
. [PMID: 38488920] - Alexander Ciji, M S Akhtar, Priyanka H Tripathi, Maneesh Kumar Dubey, Prakash Sharma. Higher intake of β-glucan impairs reproduction in a female teleost, Tor putitora (Hamilton, 1822).
Fish physiology and biochemistry.
2024 Apr; 50(2):589-603. doi:
10.1007/s10695-023-01292-4
. [PMID: 38175337] - Roy Eerlings, Purvi Gupta, Xiao Yin Lee, Tien Nguyen, Sarah El Kharraz, Florian Handle, Elien Smeets, Lisa Moris, Wout Devlies, Bram Vandewinkel, Irina Thiry, Duy Tien Ta, Anton Gorkovskiy, Karin Voordeckers, Els Henckaerts, Vitor B Pinheiro, Frank Claessens, Kevin J Verstrepen, Arnout Voet, Christine Helsen. Rational evolution for altering the ligand preference of estrogen receptor alpha.
Protein science : a publication of the Protein Society.
2024 Apr; 33(4):e4940. doi:
10.1002/pro.4940
. [PMID: 38511482] - Jiashan Li, Zhao Zou, Xiaohui Su, Panyu Xu, Hanqian Du, Yuan Li, Zehui Li, Li Guo, Na Lin, Ying Xu. Cistanche deserticola improves ovariectomized-induced osteoporosis mainly by regulating lipid metabolism: Insights from serum metabolomics using UPLC/Q-TOF-MS.
Journal of ethnopharmacology.
2024 Mar; 322(?):117570. doi:
10.1016/j.jep.2023.117570
. [PMID: 38110131] - Yuying Zhao, Hanxu Tan, Juping Zhang, Dandan Zhan, Bowen Yang, Shicui Hong, Bo Pan, Neng Wang, Tongkai Chen, Yafei Shi, Zhiyu Wang. Developing liver-targeted naringenin nanoparticles for breast cancer endocrine therapy by promoting estrogen metabolism.
Journal of nanobiotechnology.
2024 Mar; 22(1):122. doi:
10.1186/s12951-024-02356-0
. [PMID: 38504208] - Matthew P Bubak, Shivani N Mann, Agnieszka K Borowik, Atul Pranay, Albert Batushansky, Ivo Vieira de Sousa Neto, Samim A Mondal, Stephen M Doidge, Arik Davidyan, Marcelina M Szczygiel, Frederick F Peelor, Sandra Rigsby, Matle E Broomfield, Charles I Lacy, Heather C Rice, Michael B Stout, Benjamin F Miller. 17α-Estradiol alleviates high-fat diet-induced inflammatory and metabolic dysfunction in skeletal muscle of male and female mice.
American journal of physiology. Endocrinology and metabolism.
2024 Mar; 326(3):E226-E244. doi:
10.1152/ajpendo.00215.2023
. [PMID: 38197793] - Atefeh Nasri, Raimo Pohjanvirta. Comparison of in vitro Toxicities of 8-Prenylnaringenin, Tartrazine and 17β-Estradiol, Representatives of Natural and Synthetic Estrogens, in Rat and Human Hepatoma Cell Lines.
Endocrine research.
2024 Feb; 49(2):106-116. doi:
10.1080/07435800.2024.2337758
. [PMID: 38597376] - Kalpana Baghel, Zaffar Azam, Rashmi Srivastava. Dietary restriction-induced alterations on estrogen receptor alpha expression in regulating fertility in male Coturnix coturnix japonica: Relevance of Withania somnifera in modulation of inflammation and oxidative stress in testis.
American journal of reproductive immunology (New York, N.Y. : 1989).
2024 Feb; 91(2):e13816. doi:
10.1111/aji.13816
. [PMID: 38414306] - Diana Ramírez-Hernández, Pedro López-Sanchez, Diego Lezama-Martínez, Erik Pérez-García, M Fernanda Skat Montoya-Hernández, Alberto Aranda-Fraustro, Jazmin Flores-Monroy. Early Estrogen Replacement Therapy Attenuates Cardiac Dysfunction Caused by Aging and Ovariectomy in Female Wistar Rats.
Frontiers in bioscience (Landmark edition).
2024 01; 29(1):46. doi:
10.31083/j.fbl2901046
. [PMID: 38287805] - Hongyan Jin, Yan Cheng, Fanli Kong, He Huang, Zhenjun Yang, Xinyi Wang, Xinxia Cai, Jinping Luo, Tao Ming. Design and Validation of a Short Novel Estradiol Aptamer and Exploration of Its Application in Sensor Technology.
Molecules (Basel, Switzerland).
2024 Jan; 29(2):. doi:
10.3390/molecules29020535
. [PMID: 38276613] - Kristin H Cochran, Danielle C Westerman, Cassiana C Montagner, Scott Coffin, Lorivic Diaz, Benjamin Fryer, Gary Harraka, Elvis Genbo Xu, Ying Huang, Daniel Schlenk, Dionysios D Dionysiou, Susan D Richardson. Chlorination of Emerging Contaminants for Application in Potable Wastewater Reuse: Disinfection Byproduct Formation, Estrogen Activity, and Cytotoxicity.
Environmental science & technology.
2024 Jan; 58(1):704-716. doi:
10.1021/acs.est.3c05978
. [PMID: 38109774] - Qi-Meng Zhu, Chao Wang, Jing-Wen Liu, Rui Zhang, Xiu-Lan Xin, Juan Zhang, Cheng-Peng Sun, Xiao-Chi Ma. Degradation profile of environmental pollutant 17β-estradiol by human intestinal fungus Aspergillus niger RG13B1 and characterization of genes involved in its degradation.
Journal of hazardous materials.
2024 01; 461(?):132617. doi:
10.1016/j.jhazmat.2023.132617
. [PMID: 37774607] - Kejal Kantarci, Nirubol Tosakulwong, Timothy G Lesnick, Firat Kara, June Kendall-Thomas, Ekta Kapoor, Julie A Fields, Taryn T James, Rogerio A Lobo, JoAnn E Manson, Lubna Pal, Dustin B Hammers, Michael Malek-Ahmadi, Marcelle I Cedars, Frederick N Naftolin, Nanette Santoro, Virginia M Miller, Sherman M Harman, N Maritza Dowling, Carey E Gleason. Cardiometabolic outcomes in Kronos Early Estrogen Prevention Study continuation: 14-year follow-up of a hormone therapy trial.
Menopause (New York, N.Y.).
2024 Jan; 31(1):10-17. doi:
10.1097/gme.0000000000002278
. [PMID: 37989141] - M Kotula-Balak, G Lonc, M Zarzycka, J Tomiyasu, K Knapczyk-Stwora, B J Płachno, A J Korzekwa, J Kaczmarczyk, I Krakowska. The uterusmasculinus of the Eurasian beaver (Castor fever L.) - The appraisal of fast hormone regulation by membrane androgen and estrogen receptors involvement.
General and comparative endocrinology.
2024 Jan; 345(?):114389. doi:
10.1016/j.ygcen.2023.114389
. [PMID: 37797800] - Qinghai Meng, Ying Chao, Shurui Zhang, Xue Ding, Han Feng, Chenyan Zhang, Bowen Liu, Weijie Zhu, Yu Li, Qichun Zhang, Huangjin Tong, Lixing Wu, Huimin Bian. Attenuation of estrogen and its receptors in the post-menopausal stage exacerbates dyslipidemia and leads to cognitive impairment.
Molecular brain.
2023 Nov; 16(1):80. doi:
10.1186/s13041-023-01068-0
. [PMID: 37986006] - Babu Lal Kumawat, Pramod Kumar, Ajit Singh Mahla, Ashok Kumar, Amit Kumar, Raghvendar Singh, Arun Kumar. A novel action of insulin sensitizing drug as a potential promotor of preovulatory follicles, ovulation rate and prolificacy in sheep.
Veterinary research communications.
2023 Nov; ?(?):. doi:
10.1007/s11259-023-10259-y
. [PMID: 37957451] - Adeola Olowofolahan, Omowumi Fatunsin, Olufunso Olorunsogo. Modulatory effect of ciprofloxacin, a broad spectrum antibacterial drug, on mPT pore using rat model with estradiol benzoate-induced endometrial hyperplasia.
Naunyn-Schmiedeberg's archives of pharmacology.
2023 Nov; ?(?):. doi:
10.1007/s00210-023-02824-8
. [PMID: 37943297] - Agata Jabłońska-Trypuć, Urszula Wydro, Elżbieta Wołejko, Marcin Makuła, Rafał Krętowski, Monika Naumowicz, Gabriela Sokołowska, Lluis Serra-Majem, Marzanna Cechowska-Pasko, Bożena Łozowicka, Piotr Kaczyński, Józefa Wiater. Selected Fungicides as Potential EDC Estrogenic Micropollutants in the Environment.
Molecules (Basel, Switzerland).
2023 Nov; 28(21):. doi:
10.3390/molecules28217437
. [PMID: 37959855] - Graziela Taís Schmitt, Marcelo Oliveira Caetano, Vinícius Martins Marques, Amanda Gonçalves Kieling, Marie Launay, Lilia Itzel Acosta Muñiz, Luciana Paulo Gomes. Comparison of 17β-estradiol, bisphenol-A and caffeine concentration levels before and after the water treatment plant.
Journal of water and health.
2023 Nov; 21(11):1716-1726. doi:
10.2166/wh.2023.234
. [PMID: 38017601] - S Nandi, Sampath Kumar B, P S P Gupta, S Mondal, V Girish Kumar. Influence of phenolic flavonols (Kaempferol, Querectin and Myricetin) on the survival and growth of ovine preantral follicles and granulosa cells cultured in vitro.
Theriogenology.
2023 Oct; 214(?):266-272. doi:
10.1016/j.theriogenology.2023.10.023
. [PMID: 37948816] - XiaoHong Lan, Shan Cai, Guoxing Li, Kousalya Prabahar, Benjamin Hernández-Wolters, Yanru Yin. Effects of Transdermal 17β-Estradiol + Norethisterone Acetate on Cardiovascular Disease Risk Factors in Postmenopausal Women: A Meta-Analysis of Data From Randomized, Controlled Trials.
Clinical therapeutics.
2023 Oct; ?(?):. doi:
10.1016/j.clinthera.2023.09.002
. [PMID: 37852812] - X U Yani, Zhang Yutong, H E Weile, Dai Linglin, Tang Ding, Wang Jialing, Zhang Xufen, Chen Qin, Chen Lifang, Wang Zhanglian, Zhan Mingjie. Efficiency and safety of acupuncture for women with premature ovarian insufficiency: study protocol for a randomized controlled trial.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2023 Oct; 43(6):1268-1274. doi:
10.19852/j.cnki.jtcm.20230214.002
. [PMID: 37946490] - Maria Isabel Lorite, Angela Maria Cuadros, Mario Rivera-Izquierdo, Victoria Sanchez-Martin, Marta Cuadros. Benefits for cardiovascular system, bone density, and quality of life of a long-term hormone therapy in hysterectomized women: a 20-year follow-up study.
Menopause (New York, N.Y.).
2023 10; 30(10):995-1001. doi:
10.1097/gme.0000000000002239
. [PMID: 37643383] - Z Bao, Z-Q Liu, P-Y He, J Adali, Y-C Yang, M Wulasihan. 17β-estradiol regulates adenosine triphosphate-binding cassette transporters A1 expression via estrogen receptor A to increase macrophage cholesterol efflux.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2023 Oct; 74(5):. doi:
10.26402/jpp.2023.5.05
. [PMID: 38085517] - L I Zhihao, Han Wenjun, Song Xiuling, L I Yan, Chen Yuelai. Electroacupuncture stimulating Zhongji (CV3), Guanyuan (CV4), and bilateral Dahe (KI12) attenuates inflammation in rats with chronic nonbacterial prostatitis induced by estradiol through inhibiting toll-like receptor 4 pathway.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2023 10; 43(5):963-972. doi:
10.19852/j.cnki.jtcm.20230608.001
. [PMID: 37679984] - Amanda Teixeira de Rezende, Ann H Mounteer. Ecological risk assessment of pharmaceuticals and endocrine disrupting compounds in Brazilian surface waters.
Environmental pollution (Barking, Essex : 1987).
2023 Sep; 338(?):122628. doi:
10.1016/j.envpol.2023.122628
. [PMID: 37783413] - Zhaoqi Yan, Yifeng Xu, Keke Li, Liangji Liu. Association between genetically proxied HMGCR inhibition and male reproductive health: A Mendelian randomization study.
Medicine.
2023 Sep; 102(39):e34690. doi:
10.1097/md.0000000000034690
. [PMID: 37773823] - Mengting Liang, Siwen Ye, Rubin Jing, Bukun Zhu, Wenjie Yuan, Xi Chu, Ying Li, Wei Zhang. Estrogen receptor alpha-mediated mitochondrial damage in intrahepatic bile duct epithelial cells leading to the pathogenesis of primary biliary cholangitis.
Environmental toxicology.
2023 Sep; ?(?):. doi:
10.1002/tox.23906
. [PMID: 37740728] - Shweta Maurya, Shashank Tripathi, Ajit Singh. Ontogeny of adropin and its receptor expression during postnatal development and its pro-gonadal role in the ovary of pre-pubertal mouse.
The Journal of steroid biochemistry and molecular biology.
2023 Sep; 234(?):106404. doi:
10.1016/j.jsbmb.2023.106404
. [PMID: 37743028] - Robert B Hood, Donghai Liang, Youran Tan, Jennifer B Ford, Irene Souter, Jorge E Chavarro, Dean P Jones, Russ Hauser, Audrey J Gaskins. Serum and follicular fluid metabolome and markers of ovarian stimulation.
Human reproduction (Oxford, England).
2023 Sep; ?(?):. doi:
10.1093/humrep/dead189
. [PMID: 37740688] - Yiming Li, Yucong Ye, Na Rihan, Qichen Jiang, Xingguo Liu, Yunlong Zhao, Xuan Che. Polystyrene nanoplastics decrease nutrient accumulation, disturb sex hormones, and inhibit reproductive development in juvenile Macrobrachium nipponense.
The Science of the total environment.
2023 Sep; 891(?):164481. doi:
10.1016/j.scitotenv.2023.164481
. [PMID: 37257611] - Zhenyu Zheng, Yidi Wang, Malong Guo, Jiayi Guo, Jiaxuan Cui, Wenxiao Zhu, Weidong Cheng, Yonghui Liu, Hongxun Cui. Estradiol is a key candidate for treating Ankylosing Spondylolisthesis with Traditional Chinese Medicine.
Computers in biology and medicine.
2023 09; 164(?):107206. doi:
10.1016/j.compbiomed.2023.107206
. [PMID: 37515871] - Omolara T Lewechi-Uke, Ikeoluwapo O Ajayi, Joshua O Akinyemi. Abdominal obesity, serum estradiol and cardiovascular risk among Nigerian postmenopausal women: a cross-sectional study.
African health sciences.
2023 Sep; 23(3):90-98. doi:
10.4314/ahs.v23i3.12
. [PMID: 38357122] - Marisol Castillo-Castrejon, Barbara Mensah Sankofi, Stevi Johnson Murguia, Abasi-Ama Udeme, Hoaning Howard Cen, Yi Han Xia, Nisha S Thomas, William L Berry, Kenneth L Jones, Vincent R Richard, Rene P Zahedi, Christoph H Borchers, James D Johnson, Elizabeth A Wellberg. FGF1 supports glycolytic metabolism through the estrogen receptor in endocrine-resistant and obesity-associated breast cancer.
Breast cancer research : BCR.
2023 08; 25(1):99. doi:
10.1186/s13058-023-01699-0
. [PMID: 37608351] - Q Zhu, S M Chen, H W Li, R R Li, S S Yang, S S Wang, Y L Zhao, C X Ning, M Liu, Y He. [Association analysis between sex hormone levels and all-cause mortality in Hainan female centenarians].
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi.
2023 Aug; 44(8):1245-1250. doi:
10.3760/cma.j.cn112338-20221130-01015
. [PMID: 37661616] - Lu Chen, Yue Xie, Minjie Li, Monika Mortimer, Fangfang Li, Liang-Hong Guo. Toxicological mechanisms of emerging per-/poly-fluoroalkyl substances: Focusing on transcriptional activity and gene expression disruption.
Toxicology.
2023 08; 494(?):153566. doi:
10.1016/j.tox.2023.153566
. [PMID: 37263573] - Joy Temiloluwa Folahan, Olufunke Esan Olorundare, Abayomi Mayowa Ajayi, Adeoye Oyetunji Oyewopo, Sunday Sokunle Soyemi, Adejuwon Adewale Adeneye, Ikechukwu Innocent Okoye, Saheed Olanrewaju Afolabi, Anoka Ayembe Njan. Oxidized dietary lipids induce vascular inflammation and atherogenesis in post-menopausal rats: estradiol and selected antihyperlipidemic drugs restore vascular health in vivo.
Lipids in health and disease.
2023 Jul; 22(1):107. doi:
10.1186/s12944-023-01818-y
. [PMID: 37495992] - Shengwei Zhang, Jing Li, Yanxia Li, Linshu Jiang, Yan Zhao, Xiaoman Jiang, Xuelian Zhang, Wenzhuo Shi. Assimilation behaviors and metabolite formations of estrone sulfate sodium (E1-3S) and 17β-estradiol-3-O-sulfate sodium (E2-3S) in the wheat.
Journal of environmental management.
2023 Jul; 345(?):118666. doi:
10.1016/j.jenvman.2023.118666
. [PMID: 37506444] - Yanwei Zhang, Jinzhao Zhou, Ling Zeng, Yifan Xiong, Xiaofei Wang, Wenpei Xiang, Ping Su. Paternal cadmium exposure affects estradiol synthesis by impairing intracellular cholesterol homeostasis and mitochondrial function in offspring female mice.
Ecotoxicology and environmental safety.
2023 Jul; 263(?):115280. doi:
10.1016/j.ecoenv.2023.115280
. [PMID: 37481860] - Patrick Anderson Santos, Samuel da Silva Aguiar, Lucas Duarte Maciel Pinheiro Freire Barbosa, Thiago Dos Santos Rosa, Marcelo Magalhães Sales, Larissa Alves Maciel, Patrício Lopes de Araújo Leite, Sara Duarte Gutierrez, Luciele Guerra Minuzzi, Caio Victor Sousa, John Eugene Lewis, Herbert Gustavo Simões. Relationship of Testosterone, LH, Estradiol, IGF-1, and SHBG with Physical Performance of Master Athletes.
Research quarterly for exercise and sport.
2023 Jul; ?(?):1-7. doi:
10.1080/02701367.2023.2212718
. [PMID: 37463231] - Claudia A Martinez, Rishi Rikhi, Nicholas Fonseca Nogueira, Mollie S Pester, Ana S Salazar, Beteal Ashinne, Natalie Aguilar, Abraham Melara, Valeria Porras, Meela Parker, Armando Mendez, Elena Cyrus, Joseph P De Santis, Deborah L Jones, Todd T Brown, Barry E Hurwitz, Maria L Alcaide. Estrogen-Based Gender-Affirming Hormone Therapy and Subclinical Cardiovascular Disease in Transgender Women with HIV.
LGBT health.
2023 Jul; ?(?):. doi:
10.1089/lgbt.2023.0010
. [PMID: 37459150] - Rocío Ayelem Conforti, María Belén Delsouc, Ana Sofia Zabala, Sandra Silvina Vallcaneras, Marilina Casais. The copper chelator ammonium tetrathiomolybdate inhibits the progression of experimental endometriosis in TNFR1-deficient mice.
Scientific reports.
2023 06; 13(1):10354. doi:
10.1038/s41598-023-37031-1
. [PMID: 37365216] - Rafael Chitolina, Patrícia Nicola, Adrieli Sachett, Fernanda Bevilaqua, Lemen Cunico, Alissara Reginatto, Kanandra Bertoncello, Katiuska Marins, Ana Paula Zanatta, Marta Medeiros, Acauane S Lima, Cristiane Parisotto, Jean Carlo O Menegatt, André F Goetten, Francielli C Zimermann, Adriano T Ramos, Valério M Portela, Marcos H Barreta, Greicy Michelle M Conterato, Leila Zanatta. Subacute exposure to Roundup® changes steroidogenesis and gene expression of the glutathione-glutaredoxin system in rat ovaries: Implications for ovarian toxicity of this glyphosate-based herbicide.
Toxicology and applied pharmacology.
2023 Jun; ?(?):116599. doi:
10.1016/j.taap.2023.116599
. [PMID: 37328116] - Xiaobo Yang, Yuanyuan Niu, Yutong Yang, Hongrui Zhou, Jing Li, Xinyue Fu, Zhiqiang Shen, Jingfeng Wang, Zhigang Qiu. Pheromone effect of estradiol regulates the conjugative transfer of pCF10 carrying antibiotic resistance genes.
Journal of hazardous materials.
2023 06; 451(?):131087. doi:
10.1016/j.jhazmat.2023.131087
. [PMID: 36889077] - Chandra Prakash, Vivek Kumar, Venkatesh Chaturvedi. Efficient removal of endocrine disrupting compounds 17 α-ethynyl estradiol and 17 β-estradiol by Enterobacter sp. strain BHUBP7 and elucidation of the degradation pathway by HRAMS analysis.
World journal of microbiology & biotechnology.
2023 Jun; 39(8):218. doi:
10.1007/s11274-023-03662-9
. [PMID: 37269502] - Na Li, Wenzhuo Rao, Shiyu Dai, Muhammad Shahid Iqbal, Haitao Shi, Li Ding, Meiling Hong. Seasonal spermatogenesis in the red-eared slider (Trachemys scripta elegans): The roles of GnRH, actin cytoskeleton, and MAPK.
Animal reproduction science.
2023 Jun; 253(?):107253. doi:
10.1016/j.anireprosci.2023.107253
. [PMID: 37224664] - Gerardo Lorenzana-Martínez, César Alejandro San Juan-García, Anne Santerre, Isaac Andrade-González, Jacinto Bañuelos-Pineda. The Phytoestrogenic Effect of Hibiscus sabdariffa Involves Estrogen Receptor α in Ovariectomized Wistar Rats.
Plant foods for human nutrition (Dordrecht, Netherlands).
2023 Jun; 78(2):426-431. doi:
10.1007/s11130-023-01061-x
. [PMID: 37314593] - Ying Tian, Yuan Xie, Zaixin Guo, Penghui Feng, Yang You, Qi Yu. 17β-oestradiol inhibits ferroptosis in the hippocampus by upregulating DHODH and further improves memory decline after ovariectomy.
Redox biology.
2023 06; 62(?):102708. doi:
10.1016/j.redox.2023.102708
. [PMID: 37116254] - D-H Lu, S-Y Zhou, L-Z Xu. Association between hormone replacement therapy and sex hormones in postmenopausal women: a systematic review and meta-analysis.
European review for medical and pharmacological sciences.
2023 Jun; 27(11):5264-5279. doi:
10.26355/eurrev_202306_32646
. [PMID: 37318501] - V A Filatova, R V Rozhivanov, I Z Bondarenko, V A Ioutsi, E N Andreeva, G A Mel'nichenko, N G Mokrysheva. [Features of steroidogenesis and arterial hypertension in men in different types of "physiological" male hyperandrogenism].
Problemy endokrinologii.
2023 May; 69(2):80-91. doi:
10.14341/probl13226
. [PMID: 37448275] - Zi Xiu, Siling Tang, Peng Kong, Mengxuan Yan, Xue Tong, Xueping Liu, Xiao Liang, Rongxia Li, Yancang Duan. The effect and mechanism of Zigui-Yichong-Fang on improving ovarian reserve in premature ovarian insufficiency by activating SIRT1/Foxo3a pathway.
Journal of ethnopharmacology.
2023 May; ?(?):116608. doi:
10.1016/j.jep.2023.116608
. [PMID: 37150421] - Auwal M Musa, Janice Kiely, Richard Luxton, Kevin C Honeychurch. An Electrochemical Screen-Printed Sensor Based on Gold-Nanoparticle-Decorated Reduced Graphene Oxide-Carbon Nanotubes Composites for the Determination of 17-β Estradiol.
Biosensors.
2023 Apr; 13(4):. doi:
10.3390/bios13040491
. [PMID: 37185565] - Ke Sui, Ali Yasrebi, Natasha Malonza, Zehra H Jaffri, Samuel E Fisher, Isaac Seelenfreund, Brandon D McGuire, Savannah A Martinez, Avery T MacDonell, Kevin M Tveter, Candace R Longoria, Sue A Shapses, Sara C Campbell, Diana E Roopchand, Troy A Roepke. Saturated fatty acids and omega-3 polyunsaturated fatty acids improve metabolic parameters in ovariectomized female mice.
Endocrinology.
2023 Apr; ?(?):. doi:
10.1210/endocr/bqad059
. [PMID: 37029960] - Dandong Wang, Liping Chang, Jiameng Hao, Jiehan Zhang, Yahui Song, Kun Ma, Shaolan Zhang, Cuiru Li, Jiaojiao Gu, Yunlong Hou, Yiling Wu. Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats.
Journal of visualized experiments : JoVE.
2023 04; ?(194):. doi:
10.3791/64884
. [PMID: 37092820] - Jing Zhu, Ling Zhang, Mengxia Ji, Bihui Jin, Jing Shu. Elevated adipose differentiation-related protein level in ovariectomized mice correlates with tissue-specific regulation of estrogen.
The journal of obstetrics and gynaecology research.
2023 Apr; 49(4):1173-1179. doi:
10.1111/jog.15565
. [PMID: 36772863] - Yujie Lu, Man Zhang, Jin Zhang, Min Jiang, Gang Bai. Psoralen prevents the inactivation of estradiol and treats osteoporosis via covalently targeting HSD17B2.
Journal of ethnopharmacology.
2023 Mar; 311(?):116426. doi:
10.1016/j.jep.2023.116426
. [PMID: 36997132] - Mona A El-Bana, Sherien M El-Daly, Enayat A Omara, Safaa M Morsy, Mehrez E El-Naggar, Dalia Medhat. Preparation of pumpkin oil-based nanoemulsion as a potential estrogen replacement therapy to alleviate neural-immune interactions in an experimental postmenopausal model.
Prostaglandins & other lipid mediators.
2023 Mar; 166(?):106730. doi:
10.1016/j.prostaglandins.2023.106730
. [PMID: 36931593] - Chun-Xiao Wei, Liang Zhang, Cong-Hui Pang, Ying-Hua Qi, Jian-Wei Zhang. Effect of the ratios of estradiol increase on the outcome of in vitro fertilization-embryo transfer with antagonist regimens: a single center retrospective cohort study.
BMC pregnancy and childbirth.
2023 Mar; 23(1):134. doi:
10.1186/s12884-023-05438-3
. [PMID: 36864417] - Piotr Pawlicki, Anna Koziorowska, Marek Koziorowski, Bernadetta Pawlicka, Michal Duliban, Jarosław Wieczorek, Bartosz J Płachno, Laura Pardyak, Anna J Korzekwa, Malgorzata Kotula-Balak. Senescence and autophagy relation with the expressional status of non-canonical estrogen receptors in testes and adrenals of roe deer (Capreolus capreolus) during the pre-rut period.
Theriogenology.
2023 Mar; 198(?):141-152. doi:
10.1016/j.theriogenology.2022.12.023
. [PMID: 36586352] - Jinman Li, Honglin Sun, Ying Wang, Jia Liu, Guang Wang. Apolipoprotein C3 is negatively associated with estrogen and mediates the protective effect of estrogen on hypertriglyceridemia in obese adults.
Lipids in health and disease.
2023 Feb; 22(1):29. doi:
10.1186/s12944-023-01797-0
. [PMID: 36855114] - Kamil Haliloğlu, Aras Türkoğlu, Özge Balpınar, Halil İbrahim Öztürk, Güller Özkan, Peter Poczai. Effects of mammalian sex hormones on in vitro organogenesis of common bean (Phaseolus vulgaris L.).
Scientific reports.
2023 02; 13(1):3337. doi:
10.1038/s41598-023-30090-4
. [PMID: 36849811] - Shunsuke Hara, Yuki Inoue, Sogo Aoki, Keisuke Tanaka, Koumei Shirasuna, Hisataka Iwata. Beneficial Effect of Polysaccharide Gel Made of Xanthan Gum and Locust Bean Gum on Bovine Oocytes.
International journal of molecular sciences.
2023 Feb; 24(4):. doi:
10.3390/ijms24043508
. [PMID: 36834915] - Guilherme Renke, Elaine Kemen, Priscila Scalabrin, Cleibe Braz, Thomaz Baesso, Marcela Batista Pereira. Cardio-Metabolic Health and HRT in Menopause: Novel Insights in Mitochondrial Biogenesis and RAAS.
Current cardiology reviews.
2023 Feb; ?(?):. doi:
10.2174/1573403x19666230206130205
. [PMID: 36748220] - Shahnaz Rimaz, Seyedeh Tayebeh Rahideh, Jamileh Abolghasemi, Shima Jazayeri, Sanaz Jamshidi, Manijeh Motevalian, Masoud Solaymani-Dodaran, Mohsen Taghizadeh, Afsaneh Gholamrezayi, Naheed Aryaeian. The effect of Cornus mas fruit extract on vasomotor symptoms and sex hormones in postmenopausal women: a randomized, double-blind, clinical trial.
Menopause (New York, N.Y.).
2023 02; 30(2):201-207. doi:
10.1097/gme.0000000000002117
. [PMID: 36696645] - Ruqun Zheng, Haoran Shen, Jie Li, Jiansen Zhao, Lingjing Lu, Mianhao Hu, Zixin Lin, Hongxia Ma, Huiyan Tan, Min Hu, Juan Li. Qi Gong Wan ameliorates adipocyte hypertrophy and inflammation in adipose tissue in a PCOS mouse model through the Nrf2/HO-1/Cyp1b1 pathway: Integrating network pharmacology and experimental validation in vivo.
Journal of ethnopharmacology.
2023 Jan; 301(?):115824. doi:
10.1016/j.jep.2022.115824
. [PMID: 36273747] - Z N Azene, S R Davis, J J McNeil, A M Tonkin, D J Handelsman, R M Islam. Estrone, sex hormone binding globulin and lipid profiles in older women: an observational study.
Climacteric : the journal of the International Menopause Society.
2023 Jan; ?(?):1-7. doi:
10.1080/13697137.2023.2165908
. [PMID: 36693423] - Emiliano Montalesi, Patrizio Cracco, Filippo Acconcia, Marco Fiocchetti, Giovanna Iucci, Chiara Battocchio, Elisabetta Orlandini, Lidia Ciccone, Susanna Nencetti, Maurizio Muzzi, Sandra Moreno, Iole Venditti, Maria Marino. Resveratrol Analogs and Prodrugs Differently Affect the Survival of Breast Cancer Cells Impairing Estrogen/Estrogen Receptor α/Neuroglobin Pathway.
International journal of molecular sciences.
2023 Jan; 24(3):. doi:
10.3390/ijms24032148
. [PMID: 36768470] - Guoyi Yang, C Mary Schooling. Investigating sex-specific associations of lipid traits with type 2 diabetes, glycemic traits and sex hormones using Mendelian randomization.
Cardiovascular diabetology.
2023 01; 22(1):3. doi:
10.1186/s12933-022-01714-2
. [PMID: 36624450] - Guangyao Lin, Xiufang Zhong, Shengnan Li, Lianwei Xu. Clinical evidence of growth hormone for infertile women with diminished ovarian reserve undergoing IVF: a systematic review and meta-analysis.
Frontiers in endocrinology.
2023; 14(?):1215755. doi:
10.3389/fendo.2023.1215755
. [PMID: 38027219] - Samar R El Khoudary, Xirun Chen, Meiyuzhen Qi, Carol A Derby, Maria M Brooks, Rebecca C Thurston, Imke Janssen, Sybil Crawford, Jennifer S Lee, Elizabeth A Jackson, Claudia U Chae, Daniel McConnell, Karen A Matthews. The independent associations of anti-Müllerian hormone and estradiol levels over the menopause transition with lipids/lipoproteins: The Study of Women's health Across the Nation.
Journal of clinical lipidology.
2023 Jan; 17(1):157-167. doi:
10.1016/j.jacl.2022.11.008
. [PMID: 36517413] - Fengyu Jin, Xiangyan Ruan, Shuang Qin, Xin Xu, Yu Yang, Muqing Gu, Yanqiu Li, Jiaojiao Cheng, Juan Du, Xiaodan Yin, Alfred O Mueck. Traditional Chinese medicine Dingkun pill to increase fertility in women with a thin endometrium-a prospective randomized study.
Frontiers in endocrinology.
2023; 14(?):1168175. doi:
10.3389/fendo.2023.1168175
. [PMID: 37842304] - Haoyuan Wu, Jing Yuan, Haixu Yin, Bo Jing, Chang Sun, Ivan Stève Nguepi Tsopmejio, Zhouyu Jin, Hui Song. Flammulina velutipes stem regulates oxidative damage and synthesis of yolk precursors in aging laying hens by regulating the liver-blood-ovary axis.
Poultry science.
2023 Jan; 102(1):102261. doi:
10.1016/j.psj.2022.102261
. [PMID: 36410067] - Yongwei Du, Baohui Xie, Maoyuan Wang, Yanbiao Zhong, Zhimai Lv, Yun Luo, Qiwei He, Zhen Liu. Roles of sex hormones in mediating the causal effect of vitamin D on osteoporosis: A two-step Mendelian randomization study.
Frontiers in endocrinology.
2023; 14(?):1159241. doi:
10.3389/fendo.2023.1159241
. [PMID: 37082118] - Songjun Liu, Xinran Cao, Tao Zhang, Chenyang Zhang, Jiao Qu, Yang Sun, Wen Lv, Fan Qu. Paeonol ameliorates endometrial hyperplasia in mice via inhibiting PI3K/AKT pathway-related ferroptosis.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2023 Jan; 109(?):154593. doi:
10.1016/j.phymed.2022.154593
. [PMID: 36610113] - Liangliang Zhu, Hui Lv, Ling Xiao, Yanyao Hou, Wenjuan Li, Guangbo Ge, Chunzhi Ai. Diverse effects of α-/β-estradiol on catalytic activities of human UDP-glucuronosyltransferases (UGT).
The Journal of steroid biochemistry and molecular biology.
2023 01; 225(?):106196. doi:
10.1016/j.jsbmb.2022.106196
. [PMID: 36181991] - Lawrence M Nelson, Hillary Spencer, Karima Hijane, Payom Thinuan, Chaninan W Nelson, Amanda J Vincent, Catherine M Gordon, Tony M Plant, Pouneh K Fazeli. My 28 Days - a global digital women's health initiative for evaluation and management of secondary amenorrhea: case report and literature review.
Frontiers in endocrinology.
2023; 14(?):1227253. doi:
10.3389/fendo.2023.1227253
. [PMID: 37772077] - Prem Kumar, P Behera, G Biswas, T K Ghoshal, Sanjoy Das, M Kailasam, K P Jithendran. Gonad recrudescence and annual sex steroid patterns in female goldspot mullet, Liza parsia reared in brackishwater pond.
Animal reproduction science.
2023 Jan; 248(?):107161. doi:
10.1016/j.anireprosci.2022.107161
. [PMID: 36542925] - Juliana M Kling, N Maritza Dowling, Heather Bimonte-Nelson, Carey E Gleason, Kejal Kantarci, Cynthia M Stonnington, S Mitch Harman, Frederick Naftolin, Lubna Pal, Marcelle Cedars, JoAnn E Manson, Taryn T James, Eliot A Brinton, Virginia M Miller. Associations between pituitary-ovarian hormones and cognition in recently menopausal women independent of type of hormone therapy.
Maturitas.
2023 01; 167(?):113-122. doi:
10.1016/j.maturitas.2022.10.002
. [PMID: 36395695] - Allan Dos Santos Argolo, Giselle Gomes, Daniele Maia Bila. (Anti)estrogenic activity impacted by complex environmental matrices: A DOM and multiphase distribution approach.
Chemosphere.
2023 Jan; 310(?):136917. doi:
10.1016/j.chemosphere.2022.136917
. [PMID: 36272630] - Fang Yang, Jin-Chun Lu, Tao Shen, Yi-Han Jin, Yuan-Jiao Liang. Effect of hyperlipidemia on the outcome of in vitro fertilization in non-obese patients with polycystic ovary syndrome.
Frontiers in endocrinology.
2023; 14(?):1281794. doi:
10.3389/fendo.2023.1281794
. [PMID: 38033994] - Łukasz Szczerbiński, Michał Andrzej Okruszko, Maciej Szabłowski, Sebastian Sołomacha, Paweł Sowa, Łukasz Kiszkiel, Joanna Gościk, Adam Jacek Krętowski, Anna Moniuszko-Malinowska, Karol Kamiński. Long-term effects of COVID-19 on the endocrine system - a pilot case-control study.
Frontiers in endocrinology.
2023; 14(?):1192174. doi:
10.3389/fendo.2023.1192174
. [PMID: 37790604] - Zhihui Song, An Yan, Zehui Guo, Yuhang Zhang, Tao Wen, Zhenzhen Li, Zhihua Yang, Rui Chen, Yi Wang. Targeting metabolic pathways: a novel therapeutic direction for type 2 diabetes.
Frontiers in cellular and infection microbiology.
2023; 13(?):1218326. doi:
10.3389/fcimb.2023.1218326
. [PMID: 37600949] - Mona M Hassan, Azza M Sarry Eldin, Noha Musa, Khaled H El-Wakil, May Ali, Hanaa H Ahmed. Insights into the implication of obesity in hypogonadism among adolescent boys.
Journal of pediatric endocrinology & metabolism : JPEM.
2022 Dec; 35(12):1497-1504. doi:
10.1515/jpem-2022-0277
. [PMID: 36282972] - Alexandra C Kendall, Suzanne M Pilkington, Jonathan R Wray, Victoria L Newton, Christopher E M Griffiths, Mike Bell, Rachel E B Watson, Anna Nicolaou. Menopause induces changes to the stratum corneum ceramide profile, which are prevented by hormone replacement therapy.
Scientific reports.
2022 12; 12(1):21715. doi:
10.1038/s41598-022-26095-0
. [PMID: 36522440] - Qiliang Pang, Aoyun Jia, Mohammad Khaldoun Al Masri, Hamed Kord Varkaneh, Ahmed Abu-Zaid, Xiang Gao. The effect of androstenedione supplementation on testosterone, estradiol, body composition, and lipid profile: a systematic review and meta-analysis of randomized controlled trials.
Hormones (Athens, Greece).
2022 Dec; 21(4):545-554. doi:
10.1007/s42000-022-00385-8
. [PMID: 35841524] - Qing Qi, Lijia Chen, Hongmei Sun, Na Zhang, Jing Zhou, Yang Zhang, Xinyan Zhang, Lisha Li, Dajin Li, Ling Wang. Low-density lipoprotein receptor deficiency reduced bone mass in mice via the c-fos/NFATc1 pathway.
Life sciences.
2022 Dec; 310(?):121073. doi:
10.1016/j.lfs.2022.121073
. [PMID: 36244411] - Yu Zhang, Li Ma, Shuguang Dong, Qiaoyan Ding, Shuman Wang, Qi Wu, Ping Ni, Hong Zhang, Yonggang Chen, Jinhu Wu, Xiong Wang. TLR4 inhibition suppresses growth in oestrogen-induced prolactinoma models.
Endocrine-related cancer.
2022 12; 29(12):703-716. doi:
10.1530/erc-22-0168
. [PMID: 36219868] - Yangyun Wang, Chaoliang Shi, Wandong Yu, Wei Jiao, Guowei Shi. Efficacy of Yougui pill combined with Buzhong Yiqi decoction in alleviating the sexual dysfunction in female rats through modulation of the gut microbiota.
Pharmaceutical biology.
2022 Dec; 60(1):46-55. doi:
10.1080/13880209.2021.2010774
. [PMID: 34904911]