Ouabain (BioDeep_00000002362)

 

Secondary id: BioDeep_00000033950, BioDeep_00000398661, BioDeep_00000637366

human metabolite PANOMIX_OTCML-2023 blood metabolite Chemicals and Drugs natural product


代谢物信息卡片


3-[(1R,3S,5S,8R,9S,10R,11R,13R,14S,17R)-1,5,11,14-tetrahydroxy-10-(hydroxymethyl)-13-methyl-3-[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2H-furan-5-one

化学式: C29H44O12 (584.2833)
中文名称: G毒毛旋花苷
谱图信息: 最多检出来源 Homo sapiens(plant) 14.47%

分子结构信息

SMILES: C(O6)(C(O)C(O)C(C(C)6)O)OC(C5)CC(C(CO)(C5(O)4)C([H])(C1(CC4)[H])C(CC(C(C(C3)=CC(O3)=O)([H])2)(C)C1(CC2)O)O)O
InChI: InChI=1S/C29H44O12/c1-13-22(34)23(35)24(36)25(40-13)41-15-8-19(32)28(12-30)21-17(3-5-27(28,37)9-15)29(38)6-4-16(14-7-20(33)39-11-14)26(29,2)10-18(21)31/h7,13,15-19,21-25,30-32,34-38H,3-6,8-12H2,1-2H3/t13-,15-,16+,17+,18+,19+,21+,22-,23+,24+,25-,26+,27-,28+,29-/m0/s1

描述信息

Ouabain is only found in individuals that have used or taken this drug. It is a cardioactive glycoside consisting of rhamnose and ouabagenin, obtained from the seeds of Strophanthus gratus and other plants of the Apocynaceae; used like digitalis. It is commonly used in cell biological studies as an inhibitor of the NA(+)-K(+)-exchanging ATPase. [PubChem]Ouabain inhibits the Na-K-ATPase membrane pump, resulting in an increase in intracellular sodium and calcium concentrations. Increased intracellular concentrations of calcium may promote activation of contractile proteins (e.g., actin, myosin). Ouabain also acts on the electrical activity of the heart, increasing the slope of phase 4 depolarization, shortening the action potential duration, and decreasing the maximal diastolic potential.
CONFIDENCE standard compound; INTERNAL_ID 472; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6235; ORIGINAL_PRECURSOR_SCAN_NO 6233
CONFIDENCE standard compound; INTERNAL_ID 472; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6272; ORIGINAL_PRECURSOR_SCAN_NO 6270
CONFIDENCE standard compound; INTERNAL_ID 472; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6219; ORIGINAL_PRECURSOR_SCAN_NO 6216
CONFIDENCE standard compound; INTERNAL_ID 472; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6224; ORIGINAL_PRECURSOR_SCAN_NO 6220
CONFIDENCE standard compound; INTERNAL_ID 472; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6194; ORIGINAL_PRECURSOR_SCAN_NO 6191
C - Cardiovascular system > C01 - Cardiac therapy > C01A - Cardiac glycosides > C01AC - Strophanthus glycosides
D020011 - Protective Agents > D002316 - Cardiotonic Agents > D002301 - Cardiac Glycosides
D020011 - Protective Agents > D002316 - Cardiotonic Agents > D013328 - Strophanthins
[Raw Data] CB084_Ouabain_pos_50eV_CB000036.txt
[Raw Data] CB084_Ouabain_pos_10eV_CB000036.txt
[Raw Data] CB084_Ouabain_pos_30eV_CB000036.txt
[Raw Data] CB084_Ouabain_pos_20eV_CB000036.txt
[Raw Data] CB084_Ouabain_pos_40eV_CB000036.txt
D002317 - Cardiovascular Agents
D004791 - Enzyme Inhibitors

同义名列表

26 个代谢物同义名

3-[(1R,3S,5S,8R,9S,10R,11R,13R,14S,17R)-1,5,11,14-tetrahydroxy-10-(hydroxymethyl)-13-methyl-3-[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2H-furan-5-one; 4-[(1S,2R,3R,5S,7S,10R,11S,14R,15R,17R)-3,7,11,17-tetrahydroxy-2-(hydroxymethyl)-15-methyl-5-{[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}tetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecan-14-yl]-2,5-dihydrofuran-2-one; 3beta-(alpha-L-rhamnopyranosyloxy)-1beta,5beta,11alpha,14beta,19beta-pentahydroxy-5beta-card-20(22)-enolide; 3-(alpha-L-Rhamnopyranosyloxy)-1beta,5beta,11alpha,14,19-pentahydroxy-5beta-card-20(22)-enolide; 3-(a-L-Rhamnopyranosyloxy)-1b,5b,11a,14,19-pentahydroxy-5b-card-20(22)-enolide; 3-(Α-L-rhamnopyranosyloxy)-1β,5β,11α,14,19-pentahydroxy-5β-card-20(22)-enolide; Ouabagenin L-Rhamnoside; Ouabain octahydric acid; Ouabagenin-L-rhamnosid; Ouabain, octahydrate; K, Acolongifloroside; Ouabain Octahydrate; Acolongifloroside K; Ouabain anhydrous; Strophanthin-g; Strophanthin g; g Strophanthin; G-Strophanthin; MLS002702983; Acocantherin; Strodival; Astrobain; Ouabaine; Ouabain; Oubain; Ouabain



数据库引用编号

36 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

22 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 ALB, AXIN2, CA1, EGFR, TNK1
Peripheral membrane protein 3 ACHE, CAV1, TNK1
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 3 CAV1, EGFR, HSP90B1
Nucleus 5 ACHE, ALB, AXIN2, EGFR, HSP90B1
cytosol 5 ALB, ATP12A, AXIN2, CA1, HSP90B1
dendrite 1 SLC8A1
centrosome 2 ALB, AXIN2
nucleoplasm 3 ATP2B1, SCNN1G, SLC8A1
Cell membrane 7 ACHE, AGTR1, ATP2B1, CAV1, EGFR, GRID1, SLC8A1
ruffle membrane 1 EGFR
Early endosome membrane 2 CAV1, EGFR
Multi-pass membrane protein 7 AGTR1, ATP12A, ATP2B1, CACNA1I, GRID1, SCNN1G, SLC8A1
Golgi apparatus membrane 1 CAV1
Synapse 3 ACHE, ATP2B1, SLC8A1
cell cortex 1 CAV1
cell junction 2 EGFR, SLC8A1
cell surface 2 ACHE, EGFR
glutamatergic synapse 3 ATP2B1, EGFR, GRID1
Golgi apparatus 3 ACHE, ALB, CAV1
Golgi membrane 3 CAV1, EGFR, INS
lysosomal membrane 1 EGF
neuromuscular junction 1 ACHE
neuronal cell body 1 SLC8A1
postsynapse 1 SLC8A1
presynaptic membrane 1 ATP2B1
sarcolemma 1 SLC8A1
smooth endoplasmic reticulum 1 HSP90B1
endosome 2 CAV1, EGFR
plasma membrane 15 ACHE, AGTR1, ATP12A, ATP2B1, AXIN2, CACNA1I, CAV1, EGF, EGFR, GRID1, KNG1, REN, SCNN1G, SLC8A1, TNK1
synaptic vesicle membrane 1 ATP2B1
Membrane 11 ACHE, AGTR1, ATP2B1, CACNA1I, CAV1, EGF, EGFR, HSP90B1, REN, SLC8A1, TNK1
apical plasma membrane 4 ATP12A, CAV1, EGFR, SCNN1G
axon 1 SLC8A1
basolateral plasma membrane 4 ATP12A, ATP2B1, CAV1, EGFR
caveola 1 CAV1
extracellular exosome 8 ALB, ATP2B1, CA1, EGF, GRID1, HSP90B1, KNG1, SCNN1G
endoplasmic reticulum 3 ALB, CAV1, HSP90B1
extracellular space 8 ACHE, ALB, EGF, EGFR, INS, KNG1, PTH, REN
perinuclear region of cytoplasm 4 ACHE, CAV1, EGFR, HSP90B1
intercalated disc 1 SLC8A1
protein-containing complex 4 ALB, CAV1, EGFR, HSP90B1
intracellular membrane-bounded organelle 1 ATP2B1
postsynaptic density 1 SLC8A1
Single-pass type I membrane protein 1 EGFR
Secreted 4 ACHE, ALB, INS, REN
extracellular region 8 ACHE, ALB, EGF, HSP90B1, INS, KNG1, PTH, REN
Extracellular side 1 ACHE
anchoring junction 1 ALB
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
nuclear membrane 1 EGFR
external side of plasma membrane 1 SCNN1G
actin cytoskeleton 1 ATP12A
T-tubule 1 SLC8A1
Z disc 1 SLC8A1
beta-catenin destruction complex 1 AXIN2
cytoplasmic vesicle 1 CAV1
midbody 1 HSP90B1
apical part of cell 1 REN
postsynaptic membrane 1 GRID1
Apical cell membrane 2 ATP12A, SCNN1G
Membrane raft 2 CAV1, EGFR
focal adhesion 3 CAV1, EGFR, HSP90B1
GABA-ergic synapse 1 GRID1
basement membrane 1 ACHE
intracellular vesicle 1 EGFR
collagen-containing extracellular matrix 2 HSP90B1, KNG1
lateral plasma membrane 1 ATP2B1
Postsynaptic cell membrane 1 GRID1
receptor complex 1 EGFR
ciliary basal body 1 ALB
cilium 1 CAV1
cell projection 1 ATP2B1
cell periphery 1 SLC8A1
centriole 1 ALB
Secreted, extracellular space 1 KNG1
Golgi apparatus, trans-Golgi network 1 CAV1
spindle pole 1 ALB
blood microparticle 2 ALB, KNG1
Basolateral cell membrane 1 ATP2B1
Lipid-anchor, GPI-anchor 1 ACHE
endosome lumen 1 INS
Lipid droplet 1 CAV1
Membrane, caveola 1 CAV1
sodium channel complex 1 SCNN1G
Melanosome 1 HSP90B1
Presynaptic cell membrane 1 ATP2B1
side of membrane 1 ACHE
sperm plasma membrane 1 HSP90B1
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 4 ALB, HSP90B1, INS, KNG1
platelet alpha granule lumen 3 ALB, EGF, KNG1
axon terminus 1 SLC8A1
voltage-gated calcium channel complex 1 CACNA1I
endocytic vesicle membrane 1 CAV1
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
postsynaptic density membrane 1 GRID1
immunological synapse 1 ATP2B1
clathrin-coated endocytic vesicle membrane 2 EGF, EGFR
Sarcoplasmic reticulum lumen 1 HSP90B1
synaptic cleft 1 ACHE
acrosomal membrane 1 CAV1
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
endocytic vesicle lumen 1 HSP90B1
endoplasmic reticulum chaperone complex 1 HSP90B1
photoreceptor ribbon synapse 1 ATP2B1
potassium:proton exchanging ATPase complex 1 ATP12A
[Isoform H]: Cell membrane 1 ACHE
ciliary transition fiber 1 ALB
caveolar macromolecular signaling complex 1 CAV1


文献列表

  • Michael Baum, Susanne Dobler. Fecal Deployment: An Alternative Way of Defensive Host Plant Cardenolide Use by Lilioceris merdigera Larvae. Journal of chemical ecology. 2024 Feb; 50(1-2):63-70. doi: 10.1007/s10886-023-01465-8. [PMID: 38062246]
  • Dmitry A Sibarov, Zoia D Zhuravleva, Margarita A Ilina, Sergei I Boikov, Yulia D Stepanenko, Tatiana V Karelina, Sergei M Antonov. Unveiling the Role of Cholesterol in Subnanomolar Ouabain Rescue of Cortical Neurons from Calcium Overload Caused by Excitotoxic Insults. Cells. 2023 08; 12(15):. doi: 10.3390/cells12152011. [PMID: 37566090]
  • Laura Espinosa Del Alba, Georg Petschenka. No physiological costs of dual sequestration of chemically different plant toxins in the milkweed bug Spilostethus saxatilis (Heteroptera: Lygaeidae). Journal of insect physiology. 2023 Apr; ?(?):104508. doi: 10.1016/j.jinsphys.2023.104508. [PMID: 37011856]
  • Patricia L Jones, Kyle R Martin, Sejal V Prachand, Amy P Hastings, Christophe Duplais, Anurag A Agrawal. Compound-Specific Behavioral and Enzymatic Resistance to Toxic Milkweed Cardenolides in a Generalist Bumblebee Pollinator. Journal of chemical ecology. 2023 Feb; ?(?):. doi: 10.1007/s10886-023-01408-3. [PMID: 36745328]
  • Tao Song, Yuanyuan Hao, Mingye Wang, Tongtong Li, Chi Zhao, Jiajia Li, Yunlong Hou. Sophoridine manifests as a leading compound for anti-arrhythmia with multiple ion-channel blocking effects. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Jan; 112(?):154688. doi: 10.1016/j.phymed.2023.154688. [PMID: 36738478]
  • Gokhan Yilmaz, Mustafa Boz, Alper B Iskit. The Effects of Lipopolysaccharide Derivatives in Rodent Models of Cardiac Arrhythmia. Anatolian journal of cardiology. 2022 12; 26(12):886-892. doi: 10.5152/anatoljcardiol.2022.1524. [PMID: 35949121]
  • Violetta V Kravtsova, Arina A Fedorova, Maria V Tishkova, Alexandra A Livanova, Viacheslav O Matytsin, Viacheslav P Ganapolsky, Oleg V Vetrovoy, Igor I Krivoi. Short-Term Mild Hypoxia Modulates Na,K-ATPase to Maintain Membrane Electrogenesis in Rat Skeletal Muscle. International journal of molecular sciences. 2022 Oct; 23(19):. doi: 10.3390/ijms231911869. [PMID: 36233169]
  • Violetta V Kravtsova, Arina A Fedorova, Maria V Tishkova, Alexandra A Livanova, Oleg V Vetrovoy, Alexander G Markov, Vladimir V Matchkov, Igor I Krivoi. Chronic Ouabain Prevents Radiation-Induced Reduction in the α2 Na,K-ATPase Function in the Rat Diaphragm Muscle. International journal of molecular sciences. 2022 Sep; 23(18):. doi: 10.3390/ijms231810921. [PMID: 36142836]
  • Takuto Fujii, Mizuki Katoh, Manami Ootsubo, Oanh T T Nguyen, Mayumi Iguchi, Takahiro Shimizu, Yoshiaki Tabuchi, Yasuharu Shimizu, Hiroshi Takeshima, Hideki Sakai. Cardiac glycosides stimulate endocytosis of GLUT1 via intracellular Na+ ,K+ -ATPase α3-isoform in human cancer cells. Journal of cellular physiology. 2022 07; 237(7):2980-2991. doi: 10.1002/jcp.30762. [PMID: 35511727]
  • Maciej Włodarczyk, Michał Gleńsk. An in-depth look into a well-known herbal drug: Fingerprinting, isolation, identification, and content estimation of saponins in different Strophanthus seeds. Planta medica. 2022 Jul; 88(8):576-586. doi: 10.1055/a-1586-1915. [PMID: 34474491]
  • Guoyao Wu, Xilong Li, Heewon Seo, Bryan A McLendon, Avery C Kramer, Fuller W Bazer, Gregory A Johnson. Osteopontin (OPN)/Secreted Phosphoprotein 1 (SPP1) Binds Integrins to Activate Transport of Ions Across the Porcine Placenta. Frontiers in bioscience (Landmark edition). 2022 04; 27(4):117. doi: 10.31083/j.fbl2704117. [PMID: 35468676]
  • Paula Fernanda Kinoshita, Ana Maria Marques Orellana, Vinicius Watanabe Nakao, Natacha Medeiros de Souza Port's, Luis Eduardo Menezes Quintas, Elisa Mitiko Kawamoto, Cristoforo Scavone. The Janus face of ouabain in Na+ /K+ -ATPase and calcium signalling in neurons. British journal of pharmacology. 2022 04; 179(8):1512-1524. doi: 10.1111/bph.15419. [PMID: 33644859]
  • Rif S El-Mallakh, Yonglin Gao, Michael Roberts, John Hamlyn. Sleep deprivation is associated with increased circulating levels of endogenous ouabain: Potential role in bipolar disorder. Psychiatry research. 2022 03; 309(?):114399. doi: 10.1016/j.psychres.2022.114399. [PMID: 35078006]
  • Artem M Tverskoi, Yuri M Poluektov, Elizaveta A Klimanova, Vladimir A Mitkevich, Alexander A Makarov, Sergei N Orlov, Irina Yu Petrushanko, Olga D Lopina. Depth of the Steroid Core Location Determines the Mode of Na,K-ATPase Inhibition by Cardiotonic Steroids. International journal of molecular sciences. 2021 Dec; 22(24):. doi: 10.3390/ijms222413268. [PMID: 34948068]
  • Lilian N D Silva, Israel J P Garcia, Jessica M M Valadares, Marco Tulio C Pessoa, Marina Marques Toledo, Matheus V Machado, Mileane Souza Busch, Isabella Rocha, José Augusto F P Villar, Georgia C Atella, Herica L Santos, Vanessa F Cortes, Leandro A Barbosa. Evaluation of Cardiotonic Steroid Modulation of Cellular Cholesterol and Phospholipid. The Journal of membrane biology. 2021 12; 254(5-6):499-512. doi: 10.1007/s00232-021-00203-z. [PMID: 34716469]
  • Metka Petrič, Anja Vidović, Klemen Dolinar, Katarina Miš, Alexander V Chibalin, Sergej Pirkmajer. Phosphorylation of Na+,K+-ATPase at Tyr10 of the α1-Subunit is Suppressed by AMPK and Enhanced by Ouabain in Cultured Kidney Cells. The Journal of membrane biology. 2021 12; 254(5-6):531-548. doi: 10.1007/s00232-021-00209-7. [PMID: 34748042]
  • Hung Caohuy, Ofer Eidelman, Tinghua Chen, Shufeng Liu, Qingfeng Yang, Alakesh Bera, Nathan I Walton, Tony T Wang, Harvey B Pollard. Common cardiac medications potently inhibit ACE2 binding to the SARS-CoV-2 Spike, and block virus penetration and infectivity in human lung cells. Scientific reports. 2021 11; 11(1):22195. doi: 10.1038/s41598-021-01690-9. [PMID: 34773067]
  • Songpeng Yang, Shu Yang, Hongying Zhang, Hui Hua, Qingbin Kong, Jiao Wang, Yangfu Jiang. Targeting Na+ /K+ -ATPase by berbamine and ouabain synergizes with sorafenib to inhibit hepatocellular carcinoma. British journal of pharmacology. 2021 11; 178(21):4389-4407. doi: 10.1111/bph.15616. [PMID: 34233013]
  • Mrudhula Sajeevadathan, Murray J Pettitt, Mary M Buhr. Are isoforms of capacitating Na+ K+ -ATPase localized to sperm head rafts?. Molecular reproduction and development. 2021 11; 88(11):731-743. doi: 10.1002/mrd.23543. [PMID: 34658111]
  • Claudia G Vasquez, Vipul T Vachharajani, Carlos Garzon-Coral, Alexander R Dunn. Physical basis for the determination of lumen shape in a simple epithelium. Nature communications. 2021 09; 12(1):5608. doi: 10.1038/s41467-021-25050-3. [PMID: 34556639]
  • Jan Škubník, Jiří Bejček, Vladimíra Svobodová Pavlíčková, Silvie Rimpelová. Repurposing Cardiac Glycosides: Drugs for Heart Failure Surmounting Viruses. Molecules (Basel, Switzerland). 2021 Sep; 26(18):. doi: 10.3390/molecules26185627. [PMID: 34577097]
  • Samuel J Ghilardi, Mark S Aronson, Allyson E Sgro. Ventral stress fibers induce plasma membrane deformation in human fibroblasts. Molecular biology of the cell. 2021 08; 32(18):1707-1723. doi: 10.1091/mbc.e21-03-0096. [PMID: 34191528]
  • Kristoffer Bernhem, Jacopo M Fontana, Daniel Svensson, Liang Zhang, Linnéa M Nilsson, Lena Scott, Hans Blom, Hjalmar Brismar, Anita Aperia. Super-resolution microscopy reveals that Na+/K+-ATPase signaling protects against glucose-induced apoptosis by deactivating Bad. Cell death & disease. 2021 07; 12(8):739. doi: 10.1038/s41419-021-04025-8. [PMID: 34315852]
  • Alejandro Ogazon Del Toro, Lidia Jimenez, Mauricio Serrano Rubi, Marcelino Cereijido, Arturo Ponce. Ouabain Enhances Gap Junctional Intercellular Communication by Inducing Paracrine Secretion of Prostaglandin E2. International journal of molecular sciences. 2021 Jun; 22(12):. doi: 10.3390/ijms22126244. [PMID: 34200582]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Jiří Bejček, Vojtěch Spiwok, Eva Kmoníčková, Silvie Rimpelová. Na+/K+-ATPase Revisited: On Its Mechanism of Action, Role in Cancer, and Activity Modulation. Molecules (Basel, Switzerland). 2021 Mar; 26(7):. doi: 10.3390/molecules26071905. [PMID: 33800655]
  • Yunhui Xu, Pauline Marck, Minqi Huang, Jeffrey X Xie, Tong Wang, Joseph I Shapiro, Liquan Cai, Feng Feng, Zijian Xie. Biased Effect of Cardiotonic Steroids on Na/K-ATPase-Mediated Signal Transduction. Molecular pharmacology. 2021 03; 99(3):217-225. doi: 10.1124/molpharm.120.000101. [PMID: 33495275]
  • Liang Chen, Jing Yue, Shulin Zhou, Yali Hu, Juan Li. Ouabain Protects Nephrogenesis in Rats Experiencing Intrauterine Growth Restriction and Partially Restores Renal Function in Adulthood. Reproductive sciences (Thousand Oaks, Calif.). 2021 01; 28(1):186-196. doi: 10.1007/s43032-020-00280-w. [PMID: 32767217]
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  • Mauricio Serrano-Rubi, Lidia Jimenez, Jacqueline Martinez-Rendon, Marcelino Cereijido, Arturo Ponce. Ouabain Promotes Gap Junctional Intercellular Communication in Cancer Cells. International journal of molecular sciences. 2020 Dec; 22(1):. doi: 10.3390/ijms22010358. [PMID: 33396341]
  • Ana F M Botelho, Ana L S Miranda, Thalita G Freitas, Paula F Milani, Tatiane Barreto, Jáder S Cruz, Marília M Melo. Comparative Cardiotoxicity of Low Doses of Digoxin, Ouabain, and Oleandrin. Cardiovascular toxicology. 2020 12; 20(6):539-547. doi: 10.1007/s12012-020-09579-1. [PMID: 32488807]
  • Qien Wang, Jing Yue, Xuan Zhou, Meihong Zheng, Bei Cao, Juan Li. Ouabain regulates kidney metabolic profiling in rat offspring of intrauterine growth restriction induced by low-protein diet. Life sciences. 2020 Oct; 259(?):118281. doi: 10.1016/j.lfs.2020.118281. [PMID: 32798554]
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