Glabridin (BioDeep_00000229958)

 

Secondary id: BioDeep_00000003700

natural product PANOMIX_OTCML-2023 Chemicals and Drugs


代谢物信息卡片


1,3-Benzenediol, 4-[(3R)-3,4-dihydro-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b]dipyran-3-yl]-; 1,3-Benzenediol, 4-(3,4-dihydro-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b]dipyran-3-yl)-, (R)-; 2H,8H-Benzo[1,2-b:3,4-b]dipyran, 1,3-benzenediol deriv.; 4-[(3R)-3,4-Dihydro-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b]dipyran-3-yl]-1,3-benzenediol; Glabridin

化学式: C20H20O4 (324.1362)
中文名称: 光甘草定
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 28.38%

分子结构信息

SMILES: c(c(O)1)c(O)ccc1[C@@](C4)([H])Cc(c3)c(O4)c(c(c3)2)C=CC(C)(C)O2
InChI: InChI=1S/C20H20O4/c1-20(2)8-7-16-18(24-20)6-3-12-9-13(11-23-19(12)16)15-5-4-14(21)10-17(15)22/h3-8,10,13,21-22H,9,11H2,1-2H3/t13-/m0/s1

描述信息

Glabridin is a member of the class of hydroxyisoflavans that is (R)-isoflavan substituted by hydroxy groups at positions 2 and 4 and a 2,2-dimethyl-2H-pyran group across positions 7 and 8 respectively. It has a role as an antiplasmodial drug. It derives from a hydride of a (R)-isoflavan.
Glabridin is a natural product found in Ornithopus sativus, Glycyrrhiza glabra, and other organisms with data available.
See also: Glycyrrhiza Glabra (part of).
C26170 - Protective Agent > C275 - Antioxidant > C306 - Bioflavonoid
Glabridin is a natural isoflavan from Glycyrrhiza uralensis, binds to and activates PPARγ, with an EC50 of 6115 nM. Glabridin exhibits antioxidant, anti-bacterial, anti-nephritic, anti-diabetic, anti-fungal, antitumor, anti-inflammatory, antiosteoporotic, cardiovascular protective, neuroprotective and radical scavenging activities[1][2].
Glabridin is a natural isoflavan from Glycyrrhiza uralensis, binds to and activates PPARγ, with an EC50 of 6115 nM. Glabridin exhibits antioxidant, anti-bacterial, anti-nephritic, anti-diabetic, anti-fungal, antitumor, anti-inflammatory, antiosteoporotic, cardiovascular protective, neuroprotective and radical scavenging activities[1][2].
Glabridin is a natural isoflavan from Glycyrrhiza uralensis, binds to and activates PPARγ, with an EC50 of 6115 nM. Glabridin exhibits antioxidant, anti-bacterial, anti-nephritic, anti-diabetic, anti-fungal, antitumor, anti-inflammatory, antiosteoporotic, cardiovascular protective, neuroprotective and radical scavenging activities[1][2].

同义名列表

32 个代谢物同义名

1,3-Benzenediol, 4-[(3R)-3,4-dihydro-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b]dipyran-3-yl]-; 1,3-Benzenediol, 4-(3,4-dihydro-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b]dipyran-3-yl)-, (R)-; 2H,8H-Benzo[1,2-b:3,4-b]dipyran, 1,3-benzenediol deriv.; 4-[(3R)-3,4-Dihydro-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b]dipyran-3-yl]-1,3-benzenediol; Glabridin; 1,3-Benzenediol,4-(3,4-dihydro-8,8-dimethyl-2H,8H-benzo(1,2-b:3,4-b)dipyran-3-yl)-,(R); 4-(3,4-Dihydro-8,8-dimethyl-2H,8H-benzo(1,2-b:3,4-b)dipyran-3-yl)-1,3-benzenediol; 1,3-Benzenediol, 4-(3,4-dihydro-8,8-dimethyl-2H,8H-benzo(1,2-b:3,4-b)dipyran-3-yl)-, (R)-; 1,3-Benzenediol, 4-[(3R)-3,4-dihydro-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b]dipyran-3-yl]-; 1,3-BENZENEDIOL, 4-((3R)-3,4-DIHYDRO-8,8-DIMETHYL-2H,8H-BENZO(1,2-B:3,4-B)DIPYRAN-3-YL)-; 1,3-Benzenediol,4-(3,4-dihydro-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b]dipyran-3-yl)-,(R)-; 4-((R)-8,8-Dimethyl-3,4-dihydro-2H,8H-benzo[1,2-b:4,3-b]dipyran-3-yl)-benzene-1,3-diol; 4-((3R)-8,8-dimethyl-3,4-dihydro-2H,8H-benzo(1,2-b:3,4-b)dipyran-3-yl)benzene-1,3-diol; 4-[(3R)-3,4-Dihydro-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b]dipyran-3-yl]-1,3-benzenediol; 4-[(3R)-8,8-dimethyl-3,4-dihydro-2H,8H-benzo[1,2-b:3,4-b]dipyran-3-yl]benzene-1,3-diol; (R)-4-(3,4-Dihydro-8,8-dimethyl-2H,8H-benzo(1,2-b:3,4-b)dipyran-3-yl)-1,3-benzenediol; 4-(3,4-dihydro-8,8-dimethyl-2H,8H-benzo(1,2-b:3,4-b)dipyran-3-yl)-1,3-benzenediol; (R)-4-(8,8-dimethyl-3,4-dihydro-2H,8H-pyrano[2,3-f]chromen-3-yl)benzene-1,3-diol; (R)-4-(8,8-dimethyl-2,3,4,8-tetrahydropyrano[2,3-f]chromen-3-yl)benzene-1,3-diol; 4-[(3R)-8,8-dimethyl-3,4-dihydro-2H-pyrano[2,3-f]chromen- 3-yl]benzene-1,3-diol; 4-[(3R)-8,8-dimethyl-3,4-dihydro-2H-pyrano[2,3-f]chromen-3-yl]benzene-1,3-diol; 4-[(3R)-8,8-DIMETHYL-2H,3H,4H,8H-PYRANO[2,3-F]CHROMEN-3-YL]BENZENE-1,3-DIOL; Glabridin, >=98\\% (HPLC), powder; Glabridin, analytical standard; GLABRIDIN [WHO-DD]; GLABRIDIN [INCI]; (R)-Glabridin; Glabridin; 4-[(3R)-8,8-dimethyl-3,4-dihydro-2H-pyrano[6,5-f]chromen-3-yl]benzene-1,3-diol; 4-[(3R)-8,8-dimethyl-3,4-dihydro-2H-pyrano[6,5-f]chromen-3-yl]resorcinol; AIDS-096010; AIDS096010; 59870-68-7; C10421; 4- [ [ (R) -3,4-Dihydro-8,8-dimethyl-2H,8H-benzo [ 1,2-b:3,4-b ] dipyran ] -3beta-yl ] -1,3-benzenediol; Glabridin; Glabridin



数据库引用编号

22 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

38 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 14 ABCB1, AKT1, APOE, BCL2, BGLAP, CASP3, GLA, MAPK14, MAPK8, MAPK9, NFKB1, PIK3CA, PPARG, TYR
Peripheral membrane protein 1 GORASP1
Endoplasmic reticulum membrane 2 BCL2, GLA
Nucleus 11 AKT1, APOE, BCL2, CASP3, GABPA, MAPK14, MAPK8, MAPK9, NFKB1, PARP1, PPARG
cytosol 10 AKT1, BCL2, CASP3, MAPK14, MAPK8, MAPK9, NFKB1, PARP1, PIK3CA, PPARG
dendrite 2 APOE, BGLAP
nuclear body 1 PARP1
nucleoplasm 9 AKT1, CASP3, GABPA, MAPK14, MAPK8, MAPK9, NFKB1, PARP1, PPARG
RNA polymerase II transcription regulator complex 1 PPARG
Cell membrane 3 ABCB1, AKT1, TNF
Cytoplasmic side 1 GORASP1
lamellipodium 2 AKT1, PIK3CA
Multi-pass membrane protein 1 ABCB1
Golgi apparatus membrane 1 GORASP1
Synapse 1 MAPK8
cell cortex 1 AKT1
cell surface 2 ABCB1, TNF
glutamatergic synapse 4 AKT1, APOE, CASP3, MAPK14
Golgi apparatus 3 APOE, GLA, GORASP1
Golgi membrane 2 GORASP1, INS
neuronal cell body 3 APOE, CASP3, TNF
postsynapse 1 AKT1
Cytoplasm, cytosol 1 PARP1
Lysosome 2 GLA, TYR
plasma membrane 6 ABCB1, AKT1, APOE, MAPK9, PIK3CA, TNF
Membrane 6 ABCB1, AKT1, APOE, BCL2, GLA, PARP1
apical plasma membrane 1 ABCB1
axon 1 MAPK8
extracellular exosome 3 ABCB1, APOE, GLA
endoplasmic reticulum 2 APOE, BCL2
extracellular space 5 APOE, BGLAP, IL6, INS, TNF
lysosomal lumen 1 GLA
perinuclear region of cytoplasm 3 PIK3CA, PPARG, TYR
Schaffer collateral - CA1 synapse 1 MAPK9
intercalated disc 1 PIK3CA
mitochondrion 5 BCL2, MAPK14, MAPK9, NFKB1, PARP1
protein-containing complex 3 AKT1, BCL2, PARP1
intracellular membrane-bounded organelle 2 PPARG, TYR
postsynaptic density 1 CASP3
Single-pass type I membrane protein 1 TYR
Secreted 4 APOE, BGLAP, IL6, INS
extracellular region 8 APOE, BGLAP, GLA, IL6, INS, MAPK14, NFKB1, TNF
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
transcription regulator complex 2 NFKB1, PARP1
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 1 TNF
Endosome, multivesicular body 1 APOE
Extracellular vesicle 1 APOE
Secreted, extracellular space, extracellular matrix 1 APOE
chylomicron 1 APOE
high-density lipoprotein particle 1 APOE
low-density lipoprotein particle 1 APOE
multivesicular body 1 APOE
very-low-density lipoprotein particle 1 APOE
perikaryon 1 BGLAP
microtubule cytoskeleton 1 AKT1
nucleolus 1 PARP1
Melanosome membrane 1 TYR
Early endosome 1 APOE
cell-cell junction 1 AKT1
Golgi-associated vesicle 1 TYR
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 2 AKT1, BGLAP
Apical cell membrane 1 ABCB1
Membrane raft 1 TNF
pore complex 1 BCL2
spindle 1 AKT1
cis-Golgi network 1 GORASP1
extracellular matrix 1 APOE
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 1 APOE
nuclear speck 2 MAPK14, MAPK9
receptor complex 1 PPARG
ciliary basal body 1 AKT1
chromatin 4 GABPA, NFKB1, PARP1, PPARG
phagocytic cup 1 TNF
Chromosome 1 PARP1
Secreted, extracellular space 1 APOE
Nucleus, nucleolus 1 PARP1
spindle pole 1 MAPK14
nuclear replication fork 1 PARP1
chromosome, telomeric region 1 PARP1
blood microparticle 1 APOE
site of double-strand break 1 PARP1
nuclear envelope 1 PARP1
endosome lumen 1 INS
Melanosome 2 APOE, TYR
myelin sheath 1 BCL2
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 3 INS, MAPK14, NFKB1
Golgi lumen 2 BGLAP, INS
endoplasmic reticulum lumen 4 APOE, BGLAP, IL6, INS
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
specific granule lumen 1 NFKB1
transport vesicle 1 INS
azurophil granule lumen 1 GLA
Endoplasmic reticulum-Golgi intermediate compartment membrane 3 GLA, GORASP1, INS
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
clathrin-coated endocytic vesicle membrane 1 APOE
endoplasmic reticulum-Golgi intermediate compartment 1 GLA
synaptic cleft 1 APOE
protein-DNA complex 1 PARP1
external side of apical plasma membrane 1 ABCB1
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
site of DNA damage 1 PARP1
discoidal high-density lipoprotein particle 1 APOE
endocytic vesicle lumen 1 APOE
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
chylomicron remnant 1 APOE
intermediate-density lipoprotein particle 1 APOE
lipoprotein particle 1 APOE
multivesicular body, internal vesicle 1 APOE
interleukin-6 receptor complex 1 IL6
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm 1 PARP1
BAD-BCL-2 complex 1 BCL2
[Nuclear factor NF-kappa-B p105 subunit]: Cytoplasm 1 NFKB1
[Nuclear factor NF-kappa-B p50 subunit]: Nucleus 1 NFKB1
I-kappaB/NF-kappaB complex 1 NFKB1
NF-kappaB p50/p65 complex 1 NFKB1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Guanjie Peng, Yangsi Li, Yiyan Zeng, Bowen Sun, Lanyue Zhang, Qingqing Liu. Effect of glabridin combined with bakuchiol on UVB-induced skin damage and its underlying mechanism: An experimental study. Journal of cosmetic dermatology. 2024 Jun; 23(6):2256-2269. doi: 10.1111/jocd.16259. [PMID: 38497297]
  • Jiyu Weng, Ying Wang, Zekai Tan, Yanghe Yuan, Shiyuan Huang, Zexi Li, Yiming Li, Lanyue Zhang, Zhiyun Du. Glabridin reduces neuroinflammation by modulating inflammatory signals in LPS-induced in vitro and in vivo models. Inflammopharmacology. 2024 Apr; 32(2):1159-1169. doi: 10.1007/s10787-023-01424-5. [PMID: 38372849]
  • Jincai Wen, Wenqing Mu, Hui Li, Yulu Yan, Xiaoyan Zhan, Wei Luo, Zhongxia Wang, Wen Kan, Jia Zhao, Siwen Hui, Ping He, Shuanglin Qin, Yingjie Xu, Ping Zhang, Xiaohe Xiao, Guang Xu, Zhaofang Bai. Glabridin improves autoimmune disease in Trex1-deficient mice by reducing type I interferon production. Molecular medicine (Cambridge, Mass.). 2023 Dec; 29(1):167. doi: 10.1186/s10020-023-00754-y. [PMID: 38066431]
  • Xinshu Zou, Shuang Cai, Tingting Wang, Sidi Zheng, Xilong Cui, Jingyou Hao, Xueying Chen, Yanyan Liu, Zhiyun Zhang, Yanhua Li. Natural Antibacterial Agent-based Nanoparticles for Effective Treatment of Intracellular MRSA Infection. Acta biomaterialia. 2023 Aug; ?(?):. doi: 10.1016/j.actbio.2023.08.004. [PMID: 37557944]
  • Sylvia Kalli, Cindy Vallieres, Joseph Violet, Jan-Willem Sanders, John Chapman, Jean-Paul Vincken, Simon V Avery, Carla Araya-Cloutier. Cellular Responses and Targets in Food Spoilage Yeasts Exposed to Antifungal Prenylated Isoflavonoids. Microbiology spectrum. 2023 Jul; ?(?):e0132723. doi: 10.1128/spectrum.01327-23. [PMID: 37428107]
  • Supaluk Krittanai, Rattanathorn Choonong, Khunkhang Butdapheng, Jakkrit Jabsanthia, Seiichi Sakamoto, Waraporn Putalun. Construction of a monoclonal antibody against glabridin (2G4) and development of an enzyme-linked immunosorbent assay. Phytochemical analysis : PCA. 2023 May; ?(?):. doi: 10.1002/pca.3237. [PMID: 37188651]
  • Mengyao Wang, Feng Zhang, Jie Zhou, Ke Gong, Shasha Chen, Xinran Zhu, Mengxue Zhang, Yajun Duan, Chenzhong Liao, Jihong Han, Zequn Yin. Glabridin Ameliorates Alcohol-Caused Liver Damage by Reducing Oxidative Stress and Inflammation via p38 MAPK/Nrf2/NF-κB Pathway. Nutrients. 2023 Apr; 15(9):. doi: 10.3390/nu15092157. [PMID: 37432306]
  • Saya Yamano, Yuka Tsukuda, Naoko Mizuhara, Yoshihiro Yamaguchi, Akira Ogita, Ken-Ichi Fujita. Dehydrozingerone enhances the fungicidal activity of glabridin against Saccharomyces cerevisiae and Candida albicans. Letters in applied microbiology. 2023 Apr; 76(4):. doi: 10.1093/lambio/ovad040. [PMID: 36990694]
  • Navid Jamali, Ehsan Heidari Soureshjani, Gholam-Reza Mobini, Mohammad Samare-Najaf, Cain C T Clark, Javad Saffari-Chaleshtori. Medicinal plant compounds as promising inhibitors of coronavirus (COVID-19) main protease: an in silico study. Journal of biomolecular structure & dynamics. 2022 10; 40(17):8073-8084. doi: 10.1080/07391102.2021.1906749. [PMID: 33970805]
  • Qing Zhang, Die Qian, Dan-Dan Tang, Jia Liu, Lin-Yu Wang, Wenwen Chen, Chun-Jie Wu, Wei Peng. Glabridin from Glycyrrhiza glabra Possesses a Therapeutic Role against Keloid via Attenuating PI3K/Akt and Transforming Growth Factor-β1/SMAD Signaling Pathways. Journal of agricultural and food chemistry. 2022 Sep; 70(35):10782-10793. doi: 10.1021/acs.jafc.2c02045. [PMID: 36005946]
  • Shipra Bhatt, Ankita Sharma, Ashish Dogra, Priyanka Sharma, Amit Kumar, Pankul Kotwal, Swarnendu Bag, Prashant Misra, Gurdarshan Singh, Ajay Kumar, Payare Lal Sangwan, Utpal Nandi. Glabridin attenuates paracetamol-induced liver injury in mice via CYP2E1-mediated inhibition of oxidative stress. Drug and chemical toxicology. 2022 Sep; 45(5):2352-2360. doi: 10.1080/01480545.2021.1945004. [PMID: 34233566]
  • Hongtao Tan, Junxian Chen, Yicong Li, Yingshan Li, Yunchang Zhong, Guangzhao Li, Lingling Liu, Yiqun Li. Glabridin, a bioactive component of licorice, ameliorates diabetic nephropathy by regulating ferroptosis and the VEGF/Akt/ERK pathways. Molecular medicine (Cambridge, Mass.). 2022 05; 28(1):58. doi: 10.1186/s10020-022-00481-w. [PMID: 35596156]
  • Qingquan Guo, Shaojuan Wu, Wenyao Liang, Jianhua Tan, Xiangmei Liu, Yuxi Yuan, Xiaohong Li, Haishan Zhao. Glabrol impurity exacerbates glabridin toxicity in zebrafish embryos by increasing myofibril disorganization. Journal of ethnopharmacology. 2022 Apr; 287(?):114963. doi: 10.1016/j.jep.2021.114963. [PMID: 34971733]
  • Xier Pan, Yushu Li, Weilin Pang, Yaqi Xue, Zhuxian Wang, Cuiping Jiang, Chunyan Shen, Qiang Liu, Li Liu. Preparation, characterisation and comparison of glabridin-loaded hydrogel-forming microneedles by chemical and physical cross-linking. International journal of pharmaceutics. 2022 Apr; 617(?):121612. doi: 10.1016/j.ijpharm.2022.121612. [PMID: 35218899]
  • Mona H Haron, Bharathi Avula, Zulfiqar Ali, Amar G Chittiboyina, Ikhlas A Khan, Jing Li, Vivian Wang, Charles Wu, Shabana I Khan. Assessment of Herb-Drug Interaction Potential of Five Common Species of Licorice and Their Phytochemical Constituents. Journal of dietary supplements. 2022 Mar; ?(?):1-20. doi: 10.1080/19390211.2022.2050875. [PMID: 35302913]
  • Chen Xing, Wen-Qiang Cui, Yue Zhang, Xin-Shu Zou, Jing-You Hao, Si-Di Zheng, Ting-Ting Wang, Xiao-Zhen Wang, Tong Wu, Yan-Yan Liu, Xue-Ying Chen, Shu-Guang Yuan, Zhi-Yun Zhang, Yan-Hua Li. Ultrasound-assisted deep eutectic solvents extraction of glabridin and isoliquiritigenin from Glycyrrhiza glabra: Optimization, extraction mechanism and in vitro bioactivities. Ultrasonics sonochemistry. 2022 Feb; 83(?):105946. doi: 10.1016/j.ultsonch.2022.105946. [PMID: 35151194]
  • Tadayuki Tsukatani, Rieko Kuroda, Tomoaki Kawaguchi. Screening biofilm eradication activity of ethanol extracts from foodstuffs: potent biofilm eradication activity of glabridin, a major flavonoid from licorice (Glycyrrhiza glabra), alone and in combination with ɛ-poly-L-lysine. World journal of microbiology & biotechnology. 2022 Jan; 38(2):24. doi: 10.1007/s11274-021-03206-z. [PMID: 34989883]
  • Vigyasa Singh, Anirban Pal, Mahendra P Darokar. Glabridin synergy with norfloxacin induces ROS in multidrug resistant Staphylococcus aureus. The Journal of general and applied microbiology. 2021 Dec; 67(6):269-272. doi: 10.2323/jgam.2021.06.002. [PMID: 34690227]
  • Chunping Yang, Linjun Xie, Yuqing Ma, Xuewei Cai, Guizhou Yue, Guangwei Qin, Min Zhang, Guoshu Gong, Xiaoli Chang, Xiaoyan Qiu, Liya Luo, Huabao Chen. Study on the fungicidal mechanism of glabridin against Fusarium graminearum. Pesticide biochemistry and physiology. 2021 Nov; 179(?):104963. doi: 10.1016/j.pestbp.2021.104963. [PMID: 34802513]
  • Anping Li, Zhongmin Zhao, Shaoyong Zhang, Zhijun Zhang, Yanping Shi. Fungicidal Activity and Mechanism of Action of Glabridin from Glycyrrhiza glabra L. International journal of molecular sciences. 2021 Oct; 22(20):. doi: 10.3390/ijms222010966. [PMID: 34681623]
  • Jing Chang, Lin Wang, Minna Zhang, Zengjiao Lai. Glabridin attenuates atopic dermatitis progression through downregulating the TLR4/MyD88/NF-κB signaling pathway. Genes & genomics. 2021 08; 43(8):847-855. doi: 10.1007/s13258-021-01081-4. [PMID: 34021857]
  • Shipra Bhatt, Vinay Kumar, Ashish Dogra, Probir Kumar Ojha, Priya Wazir, Payare Lal Sangwan, Gurdarshan Singh, Utpal Nandi. Amalgamation of in-silico, in-vitro and in-vivo approach to establish glabridin as a potential CYP2E1 inhibitor. Xenobiotica; the fate of foreign compounds in biological systems. 2021 Jun; 51(6):625-635. doi: 10.1080/00498254.2021.1883769. [PMID: 33539218]
  • Muhammed Fatih Dogan, Ali Parlar, Saliha Aysenur Cam, Elif Merve Tosun, Fatma Uysal, Seyfullah Oktay Arslan. Glabridin attenuates airway inflammation and hyperresponsiveness in a mice model of ovalbumin-induced asthma. Pulmonary pharmacology & therapeutics. 2020 08; 63(?):101936. doi: 10.1016/j.pupt.2020.101936. [PMID: 32783990]
  • Yasukiyo Yoshioka, Yumi Samukawa, Yoko Yamashita, Hitoshi Ashida. 4-Hydroxyderricin and xanthoangelol isolated from Angelica keiskei prevent dexamethasone-induced muscle loss. Food & function. 2020 Jun; 11(6):5498-5512. doi: 10.1039/d0fo00720j. [PMID: 32510085]
  • Deepak Singh Kapkoti, Shilpi Singh, Sarfaraz Alam, Feroz Khan, Suaib Luqman, Rajendra Singh Bhakuni. In vitro antiproliferative activity of glabridin derivatives and their in silico target identification. Natural product research. 2020 Jun; 34(12):1735-1742. doi: 10.1080/14786419.2018.1530228. [PMID: 30580626]
  • Ali Parlar, Seyfullah Oktay Arslan, Saliha Ayşenur Çam. Glabridin Alleviates Inflammation and Nociception in Rodents by Activating BKCa Channels and Reducing NO Levels. Biological & pharmaceutical bulletin. 2020 May; 43(5):884-897. doi: 10.1248/bpb.b20-00038. [PMID: 32147624]
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