Embelin (BioDeep_00000229897)

 

Secondary id: BioDeep_00000008033

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


2,5-Cyclohexadiene-1,4-dione, 2,5-dihydroxy-3-undecyl- (9CI)

化学式: C17H26O4 (294.1831)
中文名称: 恩贝酸, 恩贝灵, 恩贝酸/恩贝灵, 信筒子醌
谱图信息: 最多检出来源 Macaca mulatta(otcml) 50.94%

分子结构信息

SMILES: C1(O)C(=O)C(CCCCCCCCCCC)=C(O)C(=O)C=1
InChI: InChI=1S/C17H26O4/c1-2-3-4-5-6-7-8-9-10-11-13-16(20)14(18)12-15(19)17(13)21/h12,18,21H,2-11H2,1H3

描述信息

Embelin is a member of the class of dihydroxy-1,4-benzoquinones that is 2,5-dihydroxy-1,4-benzoquinone which is substituted by an undecyl group at position 3. Isolated from Lysimachia punctata and Embelia ribes, it exhibits antimicrobial, antineoplastic and inhibitory activity towards hepatitis C protease. It has a role as a hepatitis C protease inhibitor, an antimicrobial agent, an antineoplastic agent and a plant metabolite.
Embelin is a natural product found in Ardisia paniculata, Embelia tsjeriam-cottam, and other organisms with data available.
A member of the class of dihydroxy-1,4-benzoquinones that is 2,5-dihydroxy-1,4-benzoquinone which is substituted by an undecyl group at position 3. Isolated from Lysimachia punctata and Embelia ribes, it exhibits antimicrobial, antineoplastic and inhibitory activity towards hepatitis C protease.
Embelin (Embelic acid), a potent, nonpeptidic XIAP inhibitor (IC50=4.1 μM), inhibits cell growth, induces apoptosis, and activates caspase-9 in prostate cancer cells with high levels of XIAP. Embelin blocks NF-kappaB signaling pathway leading to suppression of NF-kappaB-regulated antiapoptotic and metastatic gene products. Embelin also induces autophagic and apoptotic cell death in human oral squamous cell carcinoma cells[1][2][3].
Embelin (Embelic acid), a potent, nonpeptidic XIAP inhibitor (IC50=4.1 μM), inhibits cell growth, induces apoptosis, and activates caspase-9 in prostate cancer cells with high levels of XIAP. Embelin blocks NF-kappaB signaling pathway leading to suppression of NF-kappaB-regulated antiapoptotic and metastatic gene products. Embelin also induces autophagic and apoptotic cell death in human oral squamous cell carcinoma cells[1][2][3].

同义名列表

63 个代谢物同义名

2,5-Cyclohexadiene-1,4-dione, 2,5-dihydroxy-3-undecyl-; Embelic acid;2,5-Dihydroxy-3-undecyl-1,4-benzoquinone; 2,5-dihydroxy-3-undecylcyclohexa-2,5-diene-1,4-dione; 2,5-Dihydroxy-3-undecyl-2,5-cyclohexadiene-1,4-dione; 4-08-00-02769 (Beilstein Handbook Reference); 2,5-Dihydroxy-3-undecyl-[1,4]benzoquinone; 2,5-dihydroxy-3-undecyl-1,4-benzoquinone; p-Benzoquinone, 2,5-dihydroxy-3-undecyl-; 2,5-Dihydroxy-3-undecyl-p-benzoquinone; p-Benzoquinone,5-dihydroxy-3-undecyl-; 2,4-dione, 2,5-dihydroxy-3-undecyl-; Embelin, >=98\\% (HPLC), powder; IRSFLDGTOHBADP-UHFFFAOYSA-N; potassium embelate; Spectrum5_000620; Spectrum3_001931; Spectrum4_001760; UNII-SHC6U8F5ER; Embeliaquinone; DivK1c_006597; NCI60_042031; HSCI1_000123; KBio2_001993; KBio2_004561; KBio1_001541; EMBELIN [MI]; KBio3_002783; Embelic acid; KBio2_007129; SHC6U8F5ER; Emberine; Embelin; 2,5-Cyclohexadiene-1,4-dione, 2,5-dihydroxy-3-undecyl- (9CI); 2,5-dihydroxy-3-undecyl-cyclohexa-2,5-diene-1,4-dione; Apoptosis Activator III, Embelin; Embelin, i>Embelia ribes; XIAP inhibitor, Embelin; SDCCGMLS-0066817.P001; EINECS 208-979-8; SpecPlus_000501; NCGC00025359-01; Spectrum_001513; NCGC00025359-03; NCGC00025359-02; NCGC00017248-01; SPECTRUM1504074; BSPBio_003531; KBioSS_001993; KBioGR_002240; SMR000470851; MLS000563189; E1406_SIGMA; BRN 1885786; Tocris-2156; AIDS-009914; AIDS009914; SBB005949; NSC 91874; NSC91874; 550-24-3; TNP00137; C10342; Embelin



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

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PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

64 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 14 AKT1, ANXA5, BCL2, BIRC5, CASP3, CASP8, CASP9, CAT, MAPK14, PIK3CA, PTGS2, STAT3, TP53, XIAP
Peripheral membrane protein 4 ACHE, ANXA5, GORASP1, PTGS2
Endoplasmic reticulum membrane 2 BCL2, PTGS2
Nucleus 12 ACHE, AKT1, BCL2, BIRC5, CASP3, CASP8, CASP9, MAPK14, PARP1, STAT3, TP53, XIAP
cytosol 14 AKT1, ANXA5, BCL2, BIRC5, CASP3, CASP8, CASP9, CAT, MAPK14, PARP1, PIK3CA, STAT3, TP53, XIAP
nuclear body 1 PARP1
centrosome 1 TP53
nucleoplasm 9 AKT1, BIRC5, CASP3, CASP8, MAPK14, PARP1, STAT3, TP53, XIAP
RNA polymerase II transcription regulator complex 1 STAT3
Cell membrane 3 ACHE, AKT1, TNF
Cytoplasmic side 1 GORASP1
lamellipodium 3 AKT1, CASP8, PIK3CA
Golgi apparatus membrane 1 GORASP1
Synapse 1 ACHE
cell cortex 1 AKT1
cell surface 2 ACHE, TNF
glutamatergic synapse 3 AKT1, CASP3, MAPK14
Golgi apparatus 2 ACHE, GORASP1
Golgi membrane 2 GORASP1, INS
neuromuscular junction 1 ACHE
neuronal cell body 2 CASP3, TNF
postsynapse 1 AKT1
sarcolemma 1 ANXA5
Cytoplasm, cytosol 1 PARP1
plasma membrane 5 ACHE, AKT1, PIK3CA, STAT3, TNF
Membrane 7 ACHE, AKT1, ANXA5, BCL2, CAT, PARP1, TP53
caveola 1 PTGS2
extracellular exosome 2 ANXA5, CAT
endoplasmic reticulum 3 BCL2, PTGS2, TP53
extracellular space 4 ACHE, IL6, INS, TNF
perinuclear region of cytoplasm 2 ACHE, PIK3CA
intercalated disc 1 PIK3CA
mitochondrion 7 BCL2, CASP8, CASP9, CAT, MAPK14, PARP1, TP53
protein-containing complex 9 AKT1, BCL2, BIRC5, CASP8, CASP9, CAT, PARP1, PTGS2, TP53
intracellular membrane-bounded organelle 1 CAT
Microsome membrane 1 PTGS2
postsynaptic density 1 CASP3
Secreted 3 ACHE, IL6, INS
extracellular region 7 ACHE, ANXA5, CAT, IL6, INS, MAPK14, TNF
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, CASP8
Mitochondrion matrix 1 TP53
mitochondrial matrix 2 CAT, TP53
Extracellular side 1 ACHE
transcription regulator complex 3 PARP1, STAT3, TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 2 ANXA5, TNF
microtubule cytoskeleton 2 AKT1, BIRC5
nucleolus 2 PARP1, TP53
midbody 1 BIRC5
cell-cell junction 1 AKT1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
Cell projection, lamellipodium 1 CASP8
Membrane raft 1 TNF
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 TP53
Cytoplasm, cytoskeleton, spindle 1 BIRC5
focal adhesion 2 ANXA5, CAT
microtubule 1 BIRC5
spindle 2 AKT1, BIRC5
cis-Golgi network 1 GORASP1
Peroxisome 1 CAT
basement membrane 1 ACHE
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
Nucleus, PML body 1 TP53
PML body 1 TP53
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 1 ANXA5
nuclear speck 1 MAPK14
interphase microtubule organizing center 1 BIRC5
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Zymogen granule membrane 1 ANXA5
neuron projection 1 PTGS2
ciliary basal body 1 AKT1
chromatin 3 PARP1, STAT3, TP53
phagocytic cup 1 TNF
Chromosome 2 BIRC5, PARP1
cytoskeleton 1 CASP8
centriole 1 BIRC5
Nucleus, nucleolus 1 PARP1
spindle pole 1 MAPK14
nuclear replication fork 1 PARP1
chromosome, telomeric region 1 PARP1
nuclear chromosome 1 BIRC5
Lipid-anchor, GPI-anchor 1 ACHE
site of double-strand break 2 PARP1, TP53
nuclear envelope 1 PARP1
endosome lumen 1 INS
Chromosome, centromere 1 BIRC5
Chromosome, centromere, kinetochore 1 BIRC5
cell body 1 CASP8
side of membrane 1 ACHE
germ cell nucleus 1 TP53
replication fork 1 TP53
myelin sheath 1 BCL2
ficolin-1-rich granule lumen 2 CAT, MAPK14
secretory granule lumen 3 CAT, INS, MAPK14
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 IL6, INS, PTGS2
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
kinetochore 1 BIRC5
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 2 GORASP1, INS
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
apoptosome 1 CASP9
chromosome, centromeric region 1 BIRC5
vesicle membrane 1 ANXA5
chromosome passenger complex 1 BIRC5
[Isoform 1]: Nucleus 1 TP53
cytoplasmic microtubule 1 BIRC5
synaptic cleft 1 ACHE
protein-DNA complex 1 PARP1
spindle microtubule 1 BIRC5
survivin complex 1 BIRC5
CD95 death-inducing signaling complex 1 CASP8
death-inducing signaling complex 2 CASP3, CASP8
ripoptosome 1 CASP8
site of DNA damage 1 PARP1
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
catalase complex 1 CAT
interleukin-6 receptor complex 1 IL6
endothelial microparticle 1 ANXA5
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm 1 PARP1
BAD-BCL-2 complex 1 BCL2
[Isoform H]: Cell membrane 1 ACHE
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
caspase complex 1 CASP9
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Anika, Shamsher Singh, Rimpi. Neuroprotective effects of Embelin in an ethidium bromide-induced multiple sclerosis in rats: Modulation of p38 MAPK signaling pathway. International immunopharmacology. 2024 Mar; 129(?):111639. doi: 10.1016/j.intimp.2024.111639. [PMID: 38335654]
  • Vidya V Kamble, Asif S Tamboli, Suraj D Umdale, Shabir A Rather, Hongmei Liu, Shabir Hussain Wani, Nikhil B Gaikwad. Evaluating genetic diversity of geographically diverse populations of Embelia ribes Burm f., a highly medicinal woody liana from the Western Ghats of India, using random amplified polymorphic DNA (RAPD) and intersimple sequence repeats (ISSR) markers. Molecular biology reports. 2023 Feb; 50(2):1603-1615. doi: 10.1007/s11033-022-08099-1. [PMID: 36528661]
  • Tongxin Wang, Weilei Yao, Xiaomeng Liu, Zhengxi Bao, Chenrui Lv, Feiruo Huang. Dietary Embelin Supplementation During Mid-To-Late Gestation Improves Performance and Maternal-Fetal Glucose Metabolism of Pigs. Journal of animal science. 2023 Jan; ?(?):. doi: 10.1093/jas/skad010. [PMID: 36617266]
  • Dagmara Wróbel-Biedrawa, Agnieszka Galanty, Paweł Zagrodzki, Irma Podolak. Optimization of Extraction Conditions and Cytotoxic Activity of Rapanone in Comparison to Its Homologue, Embelin. Molecules (Basel, Switzerland). 2022 Nov; 27(22):. doi: 10.3390/molecules27227912. [PMID: 36432013]
  • Qiong Fang, Zhiying Li, Ye Xue, Xin Zong, Wenshuang Ma, Guangmin Xi, XiaoFeng Zhang, Zuowei Li. Embelin enhances the sensitivity of renal cancer cells to axitinib by inhibiting HIF signaling pathway. Anti-cancer agents in medicinal chemistry. 2022 Aug; ?(?):. doi: 10.2174/1871520622666220825155125. [PMID: 36028958]
  • Antony Stalin, Appadurai Daniel Reegan, Munusamy Rajiv Gandhi, R R Saravanan, Kedike Balakrishna, Abd El-Latif Hesham, Savarimuthu Ignacimuthu, Ying Zhang. Mosquitocidal efficacy of embelin and its derivatives against Aedes aegypti L. and Culex quinquefasciatus Say. (Diptera: Culicidae) and computational analysis of acetylcholinesterase 1 (AChE1) inhibition. Computers in biology and medicine. 2022 07; 146(?):105535. doi: 10.1016/j.compbiomed.2022.105535. [PMID: 35487124]
  • Saba Maanvizhi, Narayanaswamy Radhakrishnan, Chitra Krishnan, Arumugam Gnanamani. Pharmacological evaluation of embelin - chitosan nanoparticles as an antidiabetic agent. Indian journal of pharmacology. 2022 Mar; 54(2):126-130. doi: 10.4103/ijp.ijp_47_20. [PMID: 35546464]
  • Ting Wang, Kaiju Xu, Liyun Zhao, Rongsheng Tong, Liang Xiong, Jianyou Shi. Recent research and development of NDM-1 inhibitors. European journal of medicinal chemistry. 2021 Nov; 223(?):113667. doi: 10.1016/j.ejmech.2021.113667. [PMID: 34225181]
  • Alana Shunnarah, Robin Tumlinson, Angela I Calderón. Natural Products with Potential for Nonhormonal Male Contraception. Journal of natural products. 2021 10; 84(10):2762-2774. doi: 10.1021/acs.jnatprod.1c00565. [PMID: 34633803]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Irma Podolak, Adam Mynarski, Dagmara Wróbel, Karolina Grabowska, Agnieszka Galanty. Bioactive benzoquinones content variability in red-berry and white-berry varieties of Ardisia crenata Sims. and assessment of cytotoxic activity. Natural product research. 2021 Jan; 35(1):157-161. doi: 10.1080/14786419.2019.1614575. [PMID: 31135229]
  • P Bansal, U Bhandari, K Sharma, P Arya. Embelin modulates metabolic endotoxemia and associated obesity in high fat diet fed C57BL/6 mice. Human & experimental toxicology. 2021 Jan; 40(1):60-70. doi: 10.1177/0960327120934522. [PMID: 32735172]
  • Francesco Caruso, Miriam Rossi, Jens Z Pedersen, Sandra Incerpi. Computational studies reveal mechanism by which quinone derivatives can inhibit SARS-CoV-2. Study of embelin and two therapeutic compounds of interest, methyl prednisolone and dexamethasone. Journal of infection and public health. 2020 Dec; 13(12):1868-1877. doi: 10.1016/j.jiph.2020.09.015. [PMID: 33109497]
  • Dagmara Wróbel-Biedrawa, Karolina Grabowska, Agnieszka Galanty, Danuta Sobolewska, Paweł Żmudzki, Irma Podolak. Anti-melanoma potential of two benzoquinone homologues embelin and rapanone - a comparative in vitro study. Toxicology in vitro : an international journal published in association with BIBRA. 2020 Jun; 65(?):104826. doi: 10.1016/j.tiv.2020.104826. [PMID: 32169436]
  • Tripti Khare, Sushesh Srivatsa Palakurthi, Brijesh M Shah, Srinath Palakurthi, Sharad Khare. Natural Product-Based Nanomedicine in Treatment of Inflammatory Bowel Disease. International journal of molecular sciences. 2020 May; 21(11):. doi: 10.3390/ijms21113956. [PMID: 32486445]
  • Peng Cui, Feng Qu, Nagaraja Sreeharsha, Sanjay Sharma, Anurag Mishra, Shiva K Gubbiyappa. Antiarthritic effect of chitosan nanoparticle loaded with embelin against adjuvant-induced arthritis in Wistar rats. IUBMB life. 2020 05; 72(5):1054-1064. doi: 10.1002/iub.2248. [PMID: 32043729]
  • Meryem Köse, Thanigaimalai Pillaiyar, Vigneshwaran Namasivayam, Elisabetta De Filippo, Katharina Sylvester, Trond Ulven, Ivar von Kügelgen, Christa E Müller. An Agonist Radioligand for the Proinflammatory Lipid-Activated G Protein-Coupled Receptor GPR84 Providing Structural Insights. Journal of medicinal chemistry. 2020 03; 63(5):2391-2410. doi: 10.1021/acs.jmedchem.9b01339. [PMID: 31721581]
  • Antony Stalin, Subramani Kandhasamy, Balakrishnan Senthamarai Kannan, Rama Shanker Verma, Savarimuthu Ignacimuthu, Yrjälä Kim, Qingsong Shao, Yuan Chen, Perumal Palani. Synthesis of a 1,2,3-bistriazole derivative of embelin and evaluation of its effect on high-fat diet fed-streptozotocin-induced type 2 diabetes in rats and molecular docking studies. Bioorganic chemistry. 2020 03; 96(?):103579. doi: 10.1016/j.bioorg.2020.103579. [PMID: 31978685]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Huafeng Wang, Huan Zhang, Yanxia Wang, Luhong Yang, Dong Wang. Embelin can protect mice from thioacetamide-induced acute liver injury. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2019 Oct; 118(?):109360. doi: 10.1016/j.biopha.2019.109360. [PMID: 31545222]
  • Xuexiang Qin, Kakani Meghana, Nelluri Lakshmi Sowjanya, Katakam Revathi Sushma, Ch Gopala Krishna, Jagarlamudi Manasa, Gadamsetty Jaya Alekhya Sita, Motati Gowthami, Dronadula Honeyshmitha, Gadiparthi Srikanth, Nagaraja SreeHarsha. Embelin attenuates cisplatin-induced nephrotoxicity: Involving inhibition of oxidative stress and inflammation in addition with activation of Nrf-2/Ho-1 pathway. BioFactors (Oxford, England). 2019 May; 45(3):471-478. doi: 10.1002/biof.1502. [PMID: 30893507]
  • Md Shahadat Hossan, Ayesha Fatima, Mohammed Rahmatullah, Teng Jin Khoo, Veeranoot Nissapatorn, Anastasia V Galochkina, Alexander V Slita, Anna A Shtro, Yulia Nikolaeva, Vladimir V Zarubaev, Christophe Wiart. Antiviral activity of Embelia ribes Burm. f. against influenza virus in vitro. Archives of virology. 2018 Aug; 163(8):2121-2131. doi: 10.1007/s00705-018-3842-6. [PMID: 29633078]
  • Haroon Khan, Kannan R R Rengasamy, Aini Pervaiz, Seyed Mohammad Nabavi, Atanas G Atanasov, Mohammad A Kamal. Plant-derived mPGES-1 inhibitors or suppressors: A new emerging trend in the search for small molecules to combat inflammation. European journal of medicinal chemistry. 2018 Jun; 153(?):2-28. doi: 10.1016/j.ejmech.2017.12.059. [PMID: 29329790]
  • Ankita Sharma, Navneet Kaur, Saurabh Sharma, Amit Sharma, M S Rathore, Kumar Ajay, Neeraj Mishra. Embelin-loaded guar gum microparticles for the management of ulcerative colitis. Journal of microencapsulation. 2018 Mar; 35(2):181-191. doi: 10.1080/02652048.2018.1452991. [PMID: 29544365]
  • Md Shamsir Alam, Abdul Ahad, Lubna Abidin, Mohd Aqil, Showkat Rasool Mir, Mohd Mujeeb. Embelin-loaded oral niosomes ameliorate streptozotocin-induced diabetes in Wistar rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2018 Jan; 97(?):1514-1520. doi: 10.1016/j.biopha.2017.11.073. [PMID: 29793314]
  • Minaleshewa Atlabachew, Bewketu Mehari, Sandra Combrinck, Robert McCrindle. Single-step isolation of embelin using high-performance countercurrent chromatography and determination of the fatty acid composition of seeds of Embelia schimperi. Biomedical chromatography : BMC. 2017 Dec; 31(12):. doi: 10.1002/bmc.4018. [PMID: 28557071]
  • Rimpi Arora, Rahul Deshmukh. Embelin Attenuates Intracerebroventricular Streptozotocin-Induced Behavioral, Biochemical, and Neurochemical Abnormalities in Rats. Molecular neurobiology. 2017 11; 54(9):6670-6680. doi: 10.1007/s12035-016-0182-y. [PMID: 27744573]
  • Chandran Sivasankar, Subramanian Gayathri, James Prabhanand Bhaskar, Venkat Krishnan, Shunmugiah Karutha Pandian. Evaluation of selected Indian medicinal plants for antagonistic potential against Malassezia spp. and the synergistic effect of embelin in combination with ketoconazole. Microbial pathogenesis. 2017 Sep; 110(?):66-72. doi: 10.1016/j.micpath.2017.06.026. [PMID: 28645774]
  • Sharanbasappa Durg, Naveen Kumar B, Ravichandra Vandal, Shivsharan B Dhadde, B S Thippeswamy, Veeresh P Veerapur, Shrishailappa Badami. Antipsychotic activity of embelin isolated from Embelia ribes: A preliminary study. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2017 Jun; 90(?):328-331. doi: 10.1016/j.biopha.2017.03.085. [PMID: 28376400]
  • Y Gao, J Li, X Xu, S Wang, Y Yang, J Zhou, L Zhang, F Zheng, X Li, B Wang. Embelin attenuates adipogenesis and lipogenesis through activating canonical Wnt signaling and inhibits high-fat diet-induced obesity. International journal of obesity (2005). 2017 05; 41(5):729-738. doi: 10.1038/ijo.2017.35. [PMID: 28163317]
  • Kodandaram Sumalatha, Mohan Gowda, Sreepriya Meenakshisundaram. ROS-mediated induction of apoptosis by benzoquinone embelin in human colon adenocarcinoma cells HT-29. Journal of complementary & integrative medicine. 2017 Mar; 14(2):. doi: 10.1515/jcim-2016-0131. [PMID: 28306533]
  • Kirti S Prabhu, Kodappully S Siveen, Shilpa Kuttikrishnan, Ahmad Iskandarani, Magdalini Tsakou, Iman W Achkar, Lubna Therachiyil, Roopesh Krishnankutty, Aijaz Parray, Michal Kulinski, Maysaloun Merhi, Said Dermime, Ramzi M Mohammad, Shahab Uddin. Targeting of X-linked inhibitor of apoptosis protein and PI3-kinase/AKT signaling by embelin suppresses growth of leukemic cells. PloS one. 2017; 12(7):e0180895. doi: 10.1371/journal.pone.0180895. [PMID: 28704451]
  • Daniel Pushparaju Yeggoni, Aparna Rachamallu, Rajagopal Subramanyam. Protein stability, conformational change and binding mechanism of human serum albumin upon binding of embelin and its role in disease control. Journal of photochemistry and photobiology. B, Biology. 2016 Jul; 160(?):248-59. doi: 10.1016/j.jphotobiol.2016.04.012. [PMID: 27130964]
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