Menadione (BioDeep_00000002279)

 

Secondary id: BioDeep_00000268087

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite


代谢物信息卡片


Vitamin K3: 1,4-dihydro-1,4-dioxo-2-methylnaphthalene

化学式: C11H8O2 (172.0524)
中文名称: 甲萘醌, 维生素K3
谱图信息: 最多检出来源 Homo sapiens(blood) 31.74%

分子结构信息

SMILES: CC1=CC(=O)C2=CC=CC=C2C1=O
InChI: InChI=1/C11H8O2/c1-7-6-10(12)8-4-2-3-5-9(8)11(7)13/h2-6H,1H3

描述信息

Menadione is a synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo. -- Pubchem; Despite the fact that it can serve as a precursor to various types of vitamin K, menadione is generally not used as a nutritional supplement. Large doses of menadione have been reported to cause adverse outcomes including hemolytic anemia due to G6PD deficiency, neonatal brain or liver damage, or neonatal death in some cases. Moreover, menadione supplements have been banned by the FDA because of their high toxicity. It is sometimes called vitamin K3, although derivatives of naphthoquinone without the sidechain in the 3-position cannot exert all the functions of the K vitamins. Menadione is a vitamin precursor of K2 which utilizes alkylation in the liver to yield menaquinones (MK-n, n=1-13; K2 vitamers), and hence, is better classified as a provitamin. -- Wikipedia.
B - Blood and blood forming organs > B02 - Antihemorrhagics > B02B - Vitamin k and other hemostatics > B02BA - Vitamin k
D006401 - Hematologic Agents > D003029 - Coagulants > D006490 - Hemostatics
D050299 - Fibrin Modulating Agents > D000933 - Antifibrinolytic Agents
D018977 - Micronutrients > D014815 - Vitamins
Prothrombogenic vitamin (synthetic)
Menadione is a naphthoquinone that is converted into active vitamin K2 in the body.
Menadione is a naphthoquinone that is converted into active vitamin K2 in the body.

同义名列表

62 个代谢物同义名

Vitamin K3: 1,4-dihydro-1,4-dioxo-2-methylnaphthalene; 2-methyl-1,4-dihydronaphthalene-1,4-dione; Menadione sodium bisulfite, trihydrate; 2-Methyl-1,4-naphthalenedione; 2-Methyl-1,4-naphthalendione; Vitamin K3 sodium bisulfite; 2-Methyl-1,4-naphthoquinone; Sodium bisulfite, menadione; Bisulfite, menadione sodium; 3-Methyl-1,4-naphthoquinone; Menadione sodiuM bisulfite; 2-Methyl-1,4-naphthochinon; 2-Methyl-1,4-naphthodione; 2-Methyl-1,4-naftochinon; 2-Methylnaphthoquinone; Bisulfite, menadione; Menadione bisulfite; Kipca-oil soluble; Menaquinone O; Thyloquinone; Menaphthone; Vitamin K 3; Menaphthene; menaquinone; Menaphtone; Kayquinone; Vitamin K3; vitamin K2; Menaphthon; K-Thrombyl; Vitamin K0; menadione; Prokayvit; Kaergona; Kappaxin; Klottone; Panosine; Aquinone; Mitenone; Kappaxan; Menadion; Kolklot; Mitenon; K-Vitan; Vikasol; Kaynone; Kativ-g; Hemodal; Aquakay; Vicasol; Kayklot; Kareon; Karcon; Juva-K; Synkay; Kanone; Kaykot; Koaxin; Kipca; MNQ; Menadione; Menadione



数据库引用编号

24 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(4)

BioCyc(1)

PlantCyc(0)

代谢反应

51 个相关的代谢反应过程信息。

Reactome(48)

BioCyc(2)

WikiPathways(1)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

40 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 AKT1, CASP3, CAT, EGFR, G6PD, HPGDS, MAPK14, MAPK8, NFE2L2, NQO1, XDH
Peripheral membrane protein 2 G6PD, HSD17B6
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 2 EGFR, HSP90B1
Nucleus 10 AKT1, CASP3, EGFR, HSP90B1, JUN, MAPK14, MAPK8, NFE2L2, NQO1, PARP1
cytosol 13 AKT1, CASP3, CAT, G6PD, GSR, HPGDS, HSP90B1, MAPK14, MAPK8, NFE2L2, NQO1, PARP1, XDH
dendrite 1 NQO1
nuclear body 1 PARP1
centrosome 1 NFE2L2
nucleoplasm 8 AKT1, CASP3, HPGDS, JUN, MAPK14, MAPK8, NFE2L2, PARP1
RNA polymerase II transcription regulator complex 2 JUN, NFE2L2
Cell membrane 3 AKT1, EGFR, TNF
lamellipodium 1 AKT1
ruffle membrane 1 EGFR
Early endosome membrane 2 EGFR, HSD17B6
Synapse 2 MAPK8, NQO1
cell cortex 1 AKT1
cell junction 1 EGFR
cell surface 2 EGFR, TNF
glutamatergic synapse 4 AKT1, CASP3, EGFR, MAPK14
Golgi apparatus 1 NFE2L2
Golgi membrane 2 EGFR, INS
lysosomal membrane 1 EGF
neuronal cell body 3 CASP3, NQO1, TNF
postsynapse 1 AKT1
smooth endoplasmic reticulum 1 HSP90B1
Cytoplasm, cytosol 4 G6PD, NFE2L2, NQO1, PARP1
endosome 1 EGFR
plasma membrane 5 AKT1, EGF, EGFR, NFE2L2, TNF
Membrane 8 AKT1, CAT, EGF, EGFR, G6PD, HSP90B1, NQO1, PARP1
apical plasma membrane 1 EGFR
axon 1 MAPK8
basolateral plasma membrane 1 EGFR
extracellular exosome 5 CAT, EGF, G6PD, GSR, HSP90B1
Lumenal side 1 HSD17B6
endoplasmic reticulum 2 HSD17B6, HSP90B1
extracellular space 6 EGF, EGFR, IL6, INS, TNF, XDH
perinuclear region of cytoplasm 2 EGFR, HSP90B1
mitochondrion 4 CAT, GSR, MAPK14, PARP1
protein-containing complex 5 AKT1, CAT, EGFR, HSP90B1, PARP1
intracellular membrane-bounded organelle 4 CAT, G6PD, HPGDS, HSD17B6
Microsome membrane 1 HSD17B6
postsynaptic density 1 CASP3
Single-pass type I membrane protein 1 EGFR
Secreted 2 IL6, INS
extracellular region 7 CAT, EGF, HSP90B1, IL6, INS, MAPK14, TNF
cytoplasmic side of plasma membrane 1 G6PD
mitochondrial matrix 2 CAT, GSR
transcription regulator complex 2 JUN, PARP1
centriolar satellite 1 G6PD
nuclear membrane 1 EGFR
external side of plasma membrane 2 GSR, TNF
microtubule cytoskeleton 1 AKT1
nucleolus 1 PARP1
midbody 1 HSP90B1
cell-cell junction 1 AKT1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
Membrane raft 2 EGFR, TNF
focal adhesion 3 CAT, EGFR, HSP90B1
spindle 1 AKT1
Peroxisome 2 CAT, XDH
intracellular vesicle 1 EGFR
sarcoplasmic reticulum 1 XDH
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 1 HSP90B1
nuclear speck 1 MAPK14
receptor complex 1 EGFR
ciliary basal body 1 AKT1
chromatin 3 JUN, NFE2L2, PARP1
mediator complex 1 NFE2L2
phagocytic cup 1 TNF
Chromosome 1 PARP1
Nucleus, nucleolus 1 PARP1
spindle pole 1 MAPK14
nuclear replication fork 1 PARP1
chromosome, telomeric region 1 PARP1
nuclear chromosome 1 JUN
site of double-strand break 1 PARP1
nuclear envelope 1 PARP1
endosome lumen 1 INS
Melanosome 1 HSP90B1
euchromatin 1 JUN
sperm plasma membrane 1 HSP90B1
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
ficolin-1-rich granule lumen 2 CAT, MAPK14
secretory granule lumen 3 CAT, INS, MAPK14
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 HSP90B1, IL6, INS
platelet alpha granule lumen 1 EGF
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
clathrin-coated endocytic vesicle membrane 2 EGF, EGFR
Sarcoplasmic reticulum lumen 1 HSP90B1
protein-DNA complex 2 NFE2L2, PARP1
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
site of DNA damage 1 PARP1
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
endocytic vesicle lumen 1 HSP90B1
transcription factor AP-1 complex 1 JUN
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
catalase complex 1 CAT
interleukin-6 receptor complex 1 IL6
endoplasmic reticulum chaperone complex 1 HSP90B1
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm 1 PARP1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Natália Gonçalves Silva, Marco Preto, Vitor Vasconcelos, Ralph Urbatzka. Reduction of neutral lipid reservoirs, bioconversion and untargeted metabolomics reveal distinct roles for vitamin K isoforms on lipid metabolism. Food & function. 2024 Feb; 15(4):2170-2180. doi: 10.1039/d3fo02915h. [PMID: 38312068]
  • Antonio Catalano, Khalil Mitri, Paola Perugini, Giorgia Condrò, Caroline Sands. In vitro and in vivo efficacy of a cosmetic product formulated with new lipid particles for the treatment of aged skin. Journal of cosmetic dermatology. 2023 Dec; 22(12):3329-3339. doi: 10.1111/jocd.16016. [PMID: 37803998]
  • Barbara Anne Fraser, Alexandra Louise Wilkins, Geoffry Nunzio De Iuliis, Diane Rebourcet, Brett Nixon, Robert John Aitken. Development of a model for studying the developmental consequences of oxidative sperm DNA damage by targeting redox-cycling naphthoquinones to the Sertoli cell population. Free radical biology & medicine. 2023 Jun; 206(?):50-62. doi: 10.1016/j.freeradbiomed.2023.06.008. [PMID: 37356777]
  • Youjun Zhang, Silvia Martínez Jaime, Mustafa Bulut, Alexander Graf, Alisdair R Fernie. The conditional mitochondrial protein complexome in Arabidopsis thaliana root and shoot. Plant communications. 2023 Jun; ?(?):100635. doi: 10.1016/j.xplc.2023.100635. [PMID: 37291828]
  • Xingli Huo, Huijun Liu, Shengjie Wang, Shanmei Yin, Zongning Yin. The inhibitory effect and mechanism of small molecules on acetic anhydride-induced BSA acetylation and aggregation. Colloids and surfaces. B, Biointerfaces. 2023 Mar; 225(?):113265. doi: 10.1016/j.colsurfb.2023.113265. [PMID: 36931043]
  • Jenny Beebe, Sophia Josephraj, Chao J Wang, Jacob Danielson, Qingbin Cui, Caoqinglong Huang, Lincoln Barlow, Ryan H Zhang, Taolan Zhang, Harikrishna Nakshatri, Zizheng Dong, Xiaohong Li, Jing-Yuan Liu, Jian-Ting Zhang. Therapeutic Activity of the Lansoprazole Metabolite 5-Hydroxy Lansoprazole Sulfide in Triple-Negative Breast Cancer by Inhibiting the Enoyl Reductase of Fatty Acid Synthase. Journal of medicinal chemistry. 2022 10; 65(20):13681-13691. doi: 10.1021/acs.jmedchem.2c00642. [PMID: 36257066]
  • Xun Yu, Cui Meng, Xiaocheng Tan, Yuwei Su, Zhiping Cao, Tzann-Shun Hwang, Lin Li. RsmA3 modulates RpoS through the RetS-Gac-Rsm signalling pathway in response to H2 O2 stress in the phytopathogen Pseudomonas syringae. Environmental microbiology. 2022 10; 24(10):4755-4770. doi: 10.1111/1462-2920.16132. [PMID: 35837862]
  • Ana Maria Murta Santi, Juliana Martins Ribeiro, João Luís Reis-Cunha, Gabriela de Assis Burle-Caldas, Isabella Fernandes Martins Santos, Paula Alves Silva, Daniela de Melo Resende, Daniella Castanheira Bartholomeu, Santuza Maria Ribeiro Teixeira, Silvane Maria Fonseca Murta. Disruption of multiple copies of the Prostaglandin F2alpha synthase gene affects oxidative stress response and infectivity in Trypanosoma cruzi. PLoS neglected tropical diseases. 2022 10; 16(10):e0010845. doi: 10.1371/journal.pntd.0010845. [PMID: 36260546]
  • Tianmeng Dai, Xin Zhang, Ming Li, Xinyue Tao, Min Jin, Peng Sun, Qicun Zhou, Lefei Jiao. Dietary vitamin K3 activates mitophagy, improves antioxidant capacity, immunity and affects glucose metabolism in Litopenaeus vannamei. Food & function. 2022 Jun; 13(11):6362-6372. doi: 10.1039/d2fo00865c. [PMID: 35612417]
  • Francisco J García-Machado, Ana L García-García, Andrés A Borges, David Jiménez-Arias. Root treatment with a vitamin K3 derivative: a promising alternative to synthetic fungicides against Botrytis cinerea in tomato plants. Pest management science. 2022 Mar; 78(3):974-981. doi: 10.1002/ps.6707. [PMID: 34738317]
  • Tomoko Kuroiwa, Yoshihisa Ohtani, Yoshiaki Obara, Fuminori Terada, Kimika Watanabe, Hitoshi Shirakawa, Michio Komai, Hiroshi Satoh, Shigeru Sato, Toshihiro Ichijo. Effect of vitamin K3 supplementation on immunoglobulin G concentration in colostrum of periparturient Holstein dairy cows. Animal science journal = Nihon chikusan Gakkaiho. 2022 Jan; 93(1):e13706. doi: 10.1111/asj.13706. [PMID: 35266246]
  • Hanako Bai, Hikoji Arai, Kentarou Ikuta, Sho Ishikawa, Yoshihisa Ohtani, Kunihiro Iwashita, Nao Okada, Hitoshi Shirakawa, Michio Komai, Fuminori Terada, Yoshiaki Obara. Effects of dietary vitamin K3 supplementation on vitamin K1 and K2 (menaquinone) dynamics in dairy cows. Animal science journal = Nihon chikusan Gakkaiho. 2022 Jan; 93(1):e13680. doi: 10.1111/asj.13680. [PMID: 35029011]
  • Petar D Petrov, Polina Soluyanova, Sonia Sánchez-Campos, José V Castell, Ramiro Jover. Molecular mechanisms of hepatotoxic cholestasis by clavulanic acid: Role of NRF2 and FXR pathways. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2021 Dec; 158(?):112664. doi: 10.1016/j.fct.2021.112664. [PMID: 34767876]
  • Yong He, Fei Xu, Zina Ibrahim, Qinati Feyissa, Jennifer L Reed, Jaroslav G Vostal. Viral reduction of human blood by ultraviolet A-photosensitized vitamin K5. Journal of medical virology. 2021 08; 93(8):5134-5140. doi: 10.1002/jmv.27008. [PMID: 33837954]
  • Ruyu Wang, Qing Hu, Haonan Wang, Guanghao Zhu, Mengge Wang, Qian Zhang, Yishu Zhao, Chunyu Li, Yani Zhang, Guangbo Ge, Hongzhuan Chen, Lili Chen. Identification of Vitamin K3 and its analogues as covalent inhibitors of SARS-CoV-2 3CLpro. International journal of biological macromolecules. 2021 Jul; 183(?):182-192. doi: 10.1016/j.ijbiomac.2021.04.129. [PMID: 33901557]
  • Melania Iara Funk, Melisa Ailén Conde, Graciela Piwien-Pilipuk, Romina María Uranga. Novel antiadipogenic effect of menadione in 3T3-L1 cells. Chemico-biological interactions. 2021 Jul; 343(?):109491. doi: 10.1016/j.cbi.2021.109491. [PMID: 33945810]
  • Sajjad Hassan Askari, Muhammad Arslan Ashraf, Shafaqat Ali, Muhammad Rizwan, Rizwan Rasheed. Menadione sodium bisulfite alleviated chromium effects on wheat by regulating oxidative defense, chromium speciation, and ion homeostasis. Environmental science and pollution research international. 2021 Jul; 28(27):36205-36225. doi: 10.1007/s11356-021-13221-0. [PMID: 33751380]
  • Theng Choon Ooi, Farah Wahida Ibrahim, Shakirah Ahmad, Kok Meng Chan, Lek Mun Leong, Nihayah Mohammad, Ee Ling Siew, Nor Fadilah Rajab. Antimutagenic, Cytoprotective and Antioxidant Properties of Ficus deltoidea Aqueous Extract In Vitro. Molecules (Basel, Switzerland). 2021 May; 26(11):. doi: 10.3390/molecules26113287. [PMID: 34072474]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tanja Jankovic-Karasoulos, Dale McAninch, Clare Dixon, Shalem Y-L Leemaqz, Maxime François, Wayne R Leifert, Dylan McCullough, Carmela Ricciardelli, Claire T Roberts, Tina Bianco-Miotto. The effect of zinc on human trophoblast proliferation and oxidative stress. The Journal of nutritional biochemistry. 2021 04; 90(?):108574. doi: 10.1016/j.jnutbio.2020.108574. [PMID: 33388345]
  • Qinati Feyissa, Fei Xu, Zina Ibrahim, Ying Li, Kevin L Xu, Zihan Guo, Justen Ahmad, Jaroslav G Vostal. Synergistic bactericidal effects of pairs of photosensitizer molecules activated by ultraviolet A light against bacteria in plasma. Transfusion. 2021 02; 61(2):594-602. doi: 10.1111/trf.16180. [PMID: 33219568]
  • Ewelina Bik, Lukasz Mateuszuk, Marta Stojak, Stefan Chlopicki, Malgorzata Baranska, Katarzyna Majzner. Menadione-induced endothelial inflammation detected by Raman spectroscopy. Biochimica et biophysica acta. Molecular cell research. 2021 02; 1868(2):118911. doi: 10.1016/j.bbamcr.2020.118911. [PMID: 33227312]
  • Muhammad Arslan Ashraf, Rizwan Rasheed, Sadia Zafar, Muhammad Iqbal, Zulfiqar Ahmad Saqib. Menadione sodium bisulfite neutralizes chromium phytotoxic effects in okra by regulating cytosolutes, lipid peroxidation, antioxidant system and metal uptake. International journal of phytoremediation. 2021; 23(7):736-746. doi: 10.1080/15226514.2020.1854171. [PMID: 33321045]
  • Jessie L Ellis, J Philip Karl, Angela M Oliverio, Xueyan Fu, Jason W Soares, Benjamin E Wolfe, Christopher J Hernandez, Joel B Mason, Sarah L Booth. Dietary vitamin K is remodeled by gut microbiota and influences community composition. Gut microbes. 2021 Jan; 13(1):1-16. doi: 10.1080/19490976.2021.1887721. [PMID: 33651646]
  • O B Ibitoye, T O Ajiboye. Protocatechuic acid protects against menadione-induced liver damage by up-regulating nuclear erythroid-related factor 2. Drug and chemical toxicology. 2020 Nov; 43(6):567-573. doi: 10.1080/01480545.2018.1523187. [PMID: 30585516]
  • Wencheng Xu, Hongguang Wu, Shuhe Chen, Xiaoqin Wang, Sachiko Tanaka, Kentaro Sugiyama, Haruki Yamada, Toshihiko Hirano. Cytotoxic effects of vitamins K1, K2, and K3 against human T lymphoblastoid leukemia cells through apoptosis induction and cell cycle arrest. Chemical biology & drug design. 2020 10; 96(4):1134-1147. doi: 10.1111/cbdd.13696. [PMID: 32305047]
  • Jae Yun Moon, Da Jeong Kim, Hye Sun Kim. Sulforaphane ameliorates serum starvation-induced muscle atrophy via activation of the Nrf2 pathway in cultured C2C12 cells. Cell biology international. 2020 Sep; 44(9):1831-1839. doi: 10.1002/cbin.11377. [PMID: 32401383]
  • Karzan J Salih, Owen Duncan, Lei Li, Brendan O'Leary, Ricarda Fenske, Josua Trösch, A Harvey Millar. Impact of oxidative stress on the function, abundance, and turnover of the Arabidopsis 80S cytosolic ribosome. The Plant journal : for cell and molecular biology. 2020 07; 103(1):128-139. doi: 10.1111/tpj.14713. [PMID: 32027433]
  • Xiaoyang Li, Richard A Himes, Lyndsey C Prosser, Charleston F Christie, Emma Watt, Sharon F Edwards, Cameron S Metcalf, Peter J West, Karen S Wilcox, Sherine S L Chan, C James Chou. Discovery of the First Vitamin K Analogue as a Potential Treatment of Pharmacoresistant Seizures. Journal of medicinal chemistry. 2020 06; 63(11):5865-5878. doi: 10.1021/acs.jmedchem.0c00168. [PMID: 32390424]
  • Fei Xu, Qinati Feyissa, Zina Ibrahim, Ying Li, Kevin L Xu, Zihan Guo, Justen Ahmad, Jaroslav G Vostal. Inactivation of bacteria in plasma by photosensitizers benzophenone and vitamins K3, B1 and B6 with UV A light irradiation. Photodiagnosis and photodynamic therapy. 2020 Jun; 30(?):101713. doi: 10.1016/j.pdpdt.2020.101713. [PMID: 32165334]
  • Mohamed-Elamir F Hegazy, Masashi Fukaya, Mona Dawood, Ge Yan, Anette Klinger, Edmond Fleischer, Asmaa W Zaglool, Thomas Efferth. Vitamin K3 thio-derivative: a novel specific apoptotic inducer in the doxorubicin-sensitive and -resistant cancer cells. Investigational new drugs. 2020 06; 38(3):650-661. doi: 10.1007/s10637-019-00810-7. [PMID: 31254176]
  • Ting-Hang Liu, Mohammad A Yaghmour, Miin-Huey Lee, Thomas M Gradziel, Johan H J Leveau, Richard M Bostock. An roGFP2-Based Bacterial Bioreporter for Redox Sensing of Plant Surfaces. Phytopathology. 2020 Feb; 110(2):297-308. doi: 10.1094/phyto-07-19-0237-r. [PMID: 31483224]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Albert Godoy-Hernandez, Daniel J Tate, Duncan G G McMillan. Revealing the Membrane-Bound Catalytic Oxidation of NADH by the Drug Target Type-II NADH Dehydrogenase. Biochemistry. 2019 10; 58(42):4272-4275. doi: 10.1021/acs.biochem.9b00752. [PMID: 31592658]
  • Firoz Anwar, Ruqaiyah Khan, Richa Sachan, Imran Kazmi, Alisha Rawat, Abdullah Sabih, Rajbala Singh, Muhammad Afzal, Aftab Ahmad, Abdulaziz S Al-Orab, F A Al-Abbasi, Prakash Chandra Bhatt, Vikas Kumar. Therapeutic role of calcium and vitamin K3 in chemically induced hepatocarcinogenesis - new tools for cancer treatment. Archives of physiology and biochemistry. 2019 Jul; 125(3):270-275. doi: 10.1080/13813455.2018.1455708. [PMID: 29663832]
  • Yang Yu, Jiao Du, Yabo Wang, Mengyao Zhang, Zhiqiang Huang, Junsong Cai, Anfei Fang, Yuheng Yang, Ling Qing, Chaowei Bi, Jiasen Cheng. Survival factor 1 contributes to the oxidative stress response and is required for full virulence of Sclerotinia sclerotiorum. Molecular plant pathology. 2019 07; 20(7):895-906. doi: 10.1111/mpp.12801. [PMID: 31074170]
  • Daiva Majiene, Jolita Kuseliauskyte, Arturas Stimbirys, Aiste Jekabsone. Comparison of the Effect of Native 1,4-Naphthoquinones Plumbagin, Menadione, and Lawsone on Viability, Redox Status, and Mitochondrial Functions of C6 Glioblastoma Cells. Nutrients. 2019 Jun; 11(6):. doi: 10.3390/nu11061294. [PMID: 31181639]
  • Satoshi Endo, Namiki Miyagi, Toshiyuki Matsunaga, Akira Ikari. Rabbit dehydrogenase/reductase SDR family member 11 (DHRS11): Its identity with acetohexamide reductase with broad substrate specificity and inhibitor sensitivity, different from human DHRS11. Chemico-biological interactions. 2019 May; 305(?):12-20. doi: 10.1016/j.cbi.2019.03.026. [PMID: 30926317]
  • Basheer A Balogun, Najeeb O Aliyu, Taofeek O Ajiboye. Menadione perturbs oxidative stress biomarkers and testicular function indices of rats. Journal of biochemical and molecular toxicology. 2019 May; 33(5):e22282. doi: 10.1002/jbt.22282. [PMID: 30536483]
  • Xiaoyuan Ren, Sebastin M Santhosh, Lucia Coppo, Fernando T Ogata, Jun Lu, Arne Holmgren. The combination of ascorbate and menadione causes cancer cell death by oxidative stress and replicative stress. Free radical biology & medicine. 2019 04; 134(?):350-358. doi: 10.1016/j.freeradbiomed.2019.01.037. [PMID: 30703479]
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