Clothianidin (BioDeep_00000002161)

 

Secondary id: BioDeep_00000397781

human metabolite blood metabolite natural product


代谢物信息卡片


((e)-1-(2-chloro-1,3-Thiazol-5-ylmethyl)-3-methyl-2-nitroguanidine)

化学式: C6H8ClN5O2S (249.0087)
中文名称: 1-(2-氯-5-噻唑基甲基)-3-甲基-2-硝基胍, 噻虫胺
谱图信息: 最多检出来源 Homo sapiens(blood) 31.31%

分子结构信息

SMILES: CN=C(NCC1=CN=C(Cl)S1)N[N+]([O-])=O
InChI: InChI=1S/C6H8ClN5O2S/c1-8-6(11-12(13)14)10-3-4-2-9-5(7)15-4/h2H,3H2,1H3,(H2,8,10,11)

描述信息

CONFIDENCE standard compound; INTERNAL_ID 50; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6612; ORIGINAL_PRECURSOR_SCAN_NO 6610
CONFIDENCE standard compound; INTERNAL_ID 50; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3164; ORIGINAL_PRECURSOR_SCAN_NO 3162
CONFIDENCE standard compound; INTERNAL_ID 50; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3102; ORIGINAL_PRECURSOR_SCAN_NO 3100
CONFIDENCE standard compound; INTERNAL_ID 50; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6570; ORIGINAL_PRECURSOR_SCAN_NO 6567
CONFIDENCE standard compound; INTERNAL_ID 50; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3103; ORIGINAL_PRECURSOR_SCAN_NO 3100
CONFIDENCE standard compound; INTERNAL_ID 50; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3120; ORIGINAL_PRECURSOR_SCAN_NO 3119
CONFIDENCE standard compound; INTERNAL_ID 50; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3100; ORIGINAL_PRECURSOR_SCAN_NO 3098
CONFIDENCE standard compound; INTERNAL_ID 50; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6580; ORIGINAL_PRECURSOR_SCAN_NO 6577
CONFIDENCE standard compound; INTERNAL_ID 50; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6605; ORIGINAL_PRECURSOR_SCAN_NO 6603
CONFIDENCE standard compound; INTERNAL_ID 50; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6531; ORIGINAL_PRECURSOR_SCAN_NO 6529
CONFIDENCE standard compound; INTERNAL_ID 50; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3091; ORIGINAL_PRECURSOR_SCAN_NO 3089
CONFIDENCE standard compound; INTERNAL_ID 50; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6599; ORIGINAL_PRECURSOR_SCAN_NO 6595
D010575 - Pesticides > D007306 - Insecticides > D000073943 - Neonicotinoids
CONFIDENCE standard compound; INTERNAL_ID 8455
CONFIDENCE standard compound; INTERNAL_ID 2328
D016573 - Agrochemicals

同义名列表

8 个代谢物同义名

((e)-1-(2-chloro-1,3-Thiazol-5-ylmethyl)-3-methyl-2-nitroguanidine); (E)-N-[(2-chloro-1,3-thiazol-5-yl)methyl]-N-methyl-N-nitroguanidine; 1-[(2-chloro-1,3-thiazol-5-yl)methyl]-2-methyl-3-nitroguanidine; (e)-N-(2-Chloro-5-thiazolyl)methyl-n-methyl-n-nitroguanidine; (E)-1-(2-Chloro-5-thiazolylmethyl)-3-methyl-2-nitroguanidine; Clothianidin; celero; Clothianidin



数据库引用编号

40 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

14 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 ANXA5, ARHGAP45, CAT, CYP3A4, GAP43, GRIN1, HPGDS, MAPK3
Peripheral membrane protein 4 ACHE, ANXA5, CYP1B1, GAP43
Endosome membrane 1 CD68
Endoplasmic reticulum membrane 5 CYP19A1, CYP1B1, CYP3A4, GRIN1, TMX1
Mitochondrion membrane 1 TMX1
Nucleus 6 ACHE, FOS, GPX4, H2AX, KDR, MAPK3
cytosol 7 ANXA5, ARHGAP45, CAT, FOS, GPX4, HPGDS, MAPK3
dendrite 2 GAP43, GRIN1
mitochondrial membrane 1 TMX1
centrosome 1 H2AX
nucleoplasm 4 FOS, H2AX, HPGDS, MAPK3
RNA polymerase II transcription regulator complex 1 FOS
Cell membrane 5 ACHE, GAP43, GRIN1, KDR, KIAA0319
Cytoplasmic side 1 GAP43
ruffle membrane 1 ARHGAP45
Cell projection, axon 1 GAP43
Early endosome membrane 1 KIAA0319
Multi-pass membrane protein 2 CYP19A1, GRIN1
Synapse 3 ACHE, GAP43, GRIN1
cell junction 1 KDR
cell surface 2 ACHE, GRIN1
glutamatergic synapse 1 MAPK3
Golgi apparatus 3 ACHE, KDR, MAPK3
lysosomal membrane 1 CD68
neuromuscular junction 1 ACHE
sarcolemma 1 ANXA5
synaptic vesicle 1 GRIN1
Lysosome 1 CD68
Presynapse 1 GAP43
endosome 1 KDR
plasma membrane 9 ACHE, ARHGAP45, CD68, GAP43, GRIN1, ITGAE, KDR, KIAA0319, MAPK3
terminal bouton 1 GRIN1
Membrane 12 ACHE, ANXA5, ARHGAP45, CAT, CD68, CYP19A1, CYP1B1, CYP3A4, GRIN1, ITGAE, KIAA0319, TMX1
caveola 1 MAPK3
extracellular exosome 4 ANXA5, CAT, GPX4, H2AX
Lysosome membrane 1 CD68
endoplasmic reticulum 4 CYP19A1, FOS, KDR, TMX1
extracellular space 1 ACHE
perinuclear region of cytoplasm 1 ACHE
mitochondrion 4 CAT, CYP1B1, GPX4, MAPK3
protein-containing complex 2 CAT, GPX4
intracellular membrane-bounded organelle 5 CAT, CYP1B1, CYP3A4, HPGDS, KIAA0319
Microsome membrane 3 CYP19A1, CYP1B1, CYP3A4
postsynaptic density 2 GAP43, GRIN1
Single-pass type I membrane protein 4 CD68, ITGAE, KIAA0319, TMX1
Secreted 2 ACHE, TMX1
extracellular region 6 ACHE, ANXA5, ARHGAP45, CAT, KDR, TMX1
excitatory synapse 1 GRIN1
[Isoform 2]: Secreted 1 KDR
mitochondrial matrix 1 CAT
Extracellular side 1 ACHE
anchoring junction 1 KDR
external side of plasma membrane 3 ANXA5, ITGAE, KDR
dendritic spine 1 GRIN1
perikaryon 1 GAP43
cytoplasmic vesicle 1 KIAA0319
Early endosome 3 KDR, KIAA0319, MAPK3
postsynaptic membrane 1 GRIN1
Cell projection, ruffle membrane 1 ARHGAP45
Membrane raft 1 KDR
Cell junction, focal adhesion 1 MAPK3
focal adhesion 3 ANXA5, CAT, MAPK3
GABA-ergic synapse 1 GAP43
Peroxisome 1 CAT
basement membrane 1 ACHE
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 1 ANXA5
nuclear speck 1 H2AX
Postsynaptic cell membrane 1 GRIN1
Late endosome 1 MAPK3
receptor complex 1 KDR
Zymogen granule membrane 1 ANXA5
neuron projection 1 GRIN1
chromatin 1 FOS
Late endosome membrane 1 CD68
Chromosome 1 H2AX
cytoskeleton 1 MAPK3
Lipid-anchor, GPI-anchor 1 ACHE
site of double-strand break 1 H2AX
nuclear envelope 2 GPX4, MAPK3
Endomembrane system 1 TMX1
sorting endosome 1 KDR
Membrane, caveola 1 MAPK3
mitochondria-associated endoplasmic reticulum membrane contact site 1 TMX1
Cell projection, dendrite 1 GAP43
side of membrane 1 ACHE
replication fork 1 H2AX
pseudopodium 1 MAPK3
filopodium membrane 1 GAP43
Synaptic cell membrane 1 GRIN1
synaptic membrane 1 GRIN1
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 2 ARHGAP45, CAT
endoplasmic reticulum lumen 1 MAPK3
nuclear matrix 1 FOS
male germ cell nucleus 1 H2AX
XY body 1 H2AX
azurophil granule membrane 1 CD68
azurophil granule lumen 1 ARHGAP45
postsynaptic density membrane 1 GRIN1
condensed nuclear chromosome 1 H2AX
vesicle membrane 1 ANXA5
clathrin-coated endocytic vesicle membrane 1 KIAA0319
synaptic cleft 2 ACHE, GRIN1
protein-DNA complex 1 FOS
NMDA selective glutamate receptor complex 1 GRIN1
nucleosome 1 H2AX
site of DNA damage 1 H2AX
integrin complex 1 ITGAE
Cell projection, filopodium membrane 1 GAP43
transcription factor AP-1 complex 1 FOS
catalase complex 1 CAT
[Isoform Mitochondrial]: Mitochondrion 1 GPX4
endothelial microparticle 1 ANXA5
Cell projection, growth cone membrane 1 GAP43
growth cone membrane 1 GAP43
[Isoform H]: Cell membrane 1 ACHE
[Isoform Cytoplasmic]: Cytoplasm 1 GPX4


文献列表

  • Sayantani Nanda, Abhratanu Ganguly, Moutushi Mandi, Kanchana Das, Siddhartha Ghanty, Gopal Biswas, Prem Rajak. Chronic sub-lethal exposure to clothianidin triggers organismal and sub-organismal-level health hazards in a non-target organism, Drosophila melanogaster. The Science of the total environment. 2024 Jul; 932(?):172783. doi: 10.1016/j.scitotenv.2024.172783. [PMID: 38679102]
  • Zengxin Li, Wenhong Li, Qing Mu, Yicheng Zhu, Weiwei Qin, Xiaobin Shi, Yueping He. Rifampicin synergizes the toxicity of insecticides against the green peach aphid, Myzus persicae. Ecotoxicology and environmental safety. 2024 May; 276(?):116291. doi: 10.1016/j.ecoenv.2024.116291. [PMID: 38581910]
  • Jing Zhang, Yunyun Wang, Shanbaga Wurjihu, Haonan Ruan, Ying Huang, Mengyue Guo, Dandan Kong, Jiaoyang Luo, Meihua Yang. Comprehensive analysis of neonicotinoids in Chinese commercial honey and pollen: A corresponding health risk assessment for non-targeted organisms. The Science of the total environment. 2024 Apr; 919(?):170937. doi: 10.1016/j.scitotenv.2024.170937. [PMID: 38360305]
  • Xuezhu Xiang, Yue Xie, Di Tian, Zhenguo Chen, Xiaohui Yi, Ziyan Chen, Minzhi Huang. Microbial degradation mechanism and pathway of the insecticide thiamethoxam by isolated Bacillus Cereus from activated sludge. Environmental research. 2024 Apr; 246(?):117929. doi: 10.1016/j.envres.2023.117929. [PMID: 38157972]
  • Aizhen Wang, Yanjian Wan, Wei Qi, Gaga Mahai, Xi Qian, Tongzhang Zheng, Yuanyuan Li, Shunqing Xu, Han Xiao, Wei Xia. Urinary biomarkers of exposure to organophosphate, pyrethroid, neonicotinoid insecticides and oxidative stress: A repeated measurement analysis among pregnant women. The Science of the total environment. 2024 Feb; 912(?):169565. doi: 10.1016/j.scitotenv.2023.169565. [PMID: 38145670]
  • Björn K Klatt, Annemarie Wurz, Lina Herbertsson, Maj Rundlöf, Glenn P Svensson, Jürgen Kuhn, Sofie Vessling, Bernardo de La Vega, Teja Tscharntke, Yann Clough, Henrik G Smith. Seed treatment with clothianidin induces changes in plant metabolism and alters pollinator foraging preferences. Ecotoxicology (London, England). 2023 Dec; 32(10):1247-1256. doi: 10.1007/s10646-023-02720-0. [PMID: 38062283]
  • Edmund J Norris, Jeffrey R Bloomquist. Fir (Abies balsamea) (Pinales: Pinaceae) needle essential oil enhances the knockdown activity of select insecticides. Journal of medical entomology. 2023 Nov; 60(6):1350-1356. doi: 10.1093/jme/tjad101. [PMID: 37963276]
  • Fred A Ashu, Caroline Fouet, Marilene M Ambadiang, Véronique Penlap-Beng, Colince Kamdem. Vegetable oil-based surfactants are adjuvants that enhance the efficacy of neonicotinoid insecticides and can bias susceptibility testing in adult mosquitoes. PLoS neglected tropical diseases. 2023 Nov; 17(11):e0011737. doi: 10.1371/journal.pntd.0011737. [PMID: 37976311]
  • Jinyu Hu, Buli Fu, Jinjin Liang, Rong Zhang, Xuegao Wei, Jing Yang, Qimei Tan, Hu Xue, Peipan Gong, Shaonan Liu, Mingjiao Huang, Tianhua Du, Cheng Yin, Chao He, Yao Ji, Chao Wang, Chengjia Zhang, He Du, Qi Su, Xin Yang, Youjun Zhang. CYP4CS5-mediated thiamethoxam and clothianidin resistance is accompanied by fitness cost in the whitefly Bemisia tabaci. Pest management science. 2023 Oct; ?(?):. doi: 10.1002/ps.7826. [PMID: 37822143]
  • Gaga Mahai, Yanjian Wan, Aizhen Wang, Xi Qian, Juxiao Li, Ying Li, Wenxin Zhang, Zhenyu He, Yuanyuan Li, Wei Xia, Shunqing Xu. Exposure to multiple neonicotinoid insecticides, oxidative stress, and gestational diabetes mellitus: Association and potential mediation analyses. Environment international. 2023 09; 179(?):108173. doi: 10.1016/j.envint.2023.108173. [PMID: 37651928]
  • Hongqin Yang, Lian Xia, Jia Zheng, Zhengmin Xie, Jianli Zhou, Yuangen Wu. Screening and identification of a DNA aptamer to construct the label-free fluorescent aptasensor for ultrasensitive and selective detection of clothianidin residue in agricultural products. Talanta. 2023 Sep; 262(?):124712. doi: 10.1016/j.talanta.2023.124712. [PMID: 37244242]
  • Li Li, Hongwu Liang, Wei Pan, Shijie Yin, Junli Cao, Jindong Li. Translocation and dissipation of thiamethoxam applied by root irrigation in tomato plant-soil system. Environmental science and pollution research international. 2023 Jul; ?(?):. doi: 10.1007/s11356-023-28817-x. [PMID: 37505385]
  • Sadaya Kumar Gajula, Sampath Kumar Kanthala, Madhusudan Reddy Narra, Vanita Das Vanamala. Individual and interactive biochemical profile damages in Labeo rohita (Cyprinidae) by imidacloprid and clothianidin. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2023 Jun; 271(?):109689. doi: 10.1016/j.cbpc.2023.109689. [PMID: 37356513]
  • Benjamin A Morrison, Kang Xia, Ryan D Stewart. Evaluating neonicotinoid insecticide uptake by plants used as buffers and cover crops. Chemosphere. 2023 May; 322(?):138154. doi: 10.1016/j.chemosphere.2023.138154. [PMID: 36796521]
  • Junxue Wu, Ming Zhuang, Ziyu Zou, Jianing Xin, Fang Wang, Chunhong Jia, Hongyan Zhang. Efficient degradation of clothianidin and thiamethoxam in contaminated soil by peroxymonosulfate process. Environmental science and pollution research international. 2023 Apr; 30(16):48211-48219. doi: 10.1007/s11356-023-25738-7. [PMID: 36750516]
  • Chunni Zhang, Taoling Zhou, Yao Li, Wu Dai, Shaokai Du. Activation of CncC pathway is involved in the regulation of P450 genes responsible for clothianidin resistance in Bradysia odoriphaga. Pest management science. 2023 Mar; ?(?):. doi: 10.1002/ps.7482. [PMID: 36974603]
  • Richard Odemer, Elsa Friedrich, Ingrid Illies, Stefan Berg, Jens Pistorius, Gabriela Bischoff. Potential risk of residues from neonicotinoid-treated sugar beet in flowering weeds to honey bees (Apis mellifera L.). Environmental toxicology and chemistry. 2023 Mar; ?(?):. doi: 10.1002/etc.5602. [PMID: 36861216]
  • Vincenzo Girolami, Edoardo Petrucco Toffolo, Luca Mazzon, Francesca Zampieri, Andrea Lentola, Chiara Giorio, Andrea Tapparo. Effect of repeated intakes of a neonicotinoid insecticide on the foraging behaviours of Apis mellifera in field trials. Environmental science and pollution research international. 2023 Jan; 30(5):12257-12268. doi: 10.1007/s11356-022-22977-y. [PMID: 36109478]
  • Benjamin A Morrison, Kang Xia, Ryan D Stewart. Soil organic matter can delay-but not eliminate-leaching of neonicotinoid insecticides. Journal of environmental quality. 2022 Nov; 51(6):1270-1281. doi: 10.1002/jeq2.20402. [PMID: 35989664]
  • Fajun Tian, Chengkui Qiao, Caixia Wang, Tao Pang, Linlin Guo, Jun Li, Rongli Pang, Hui Liu, Hanzhong Xie. Comparison of the effectiveness of thiamethoxam and its main metabolite clothianidin after foliar spraying and root irrigation to control Myzus persicae on peach. Scientific reports. 2022 10; 12(1):16883. doi: 10.1038/s41598-022-20659-w. [PMID: 36207356]
  • Li Li, Hongwu Liang, Tingting Zhao, Yu Liu, Sen Yan, Wentao Zhu. Differential effects of thiamethoxam and clothianidin exposure on their tissue distribution and chronic toxicity in mice. Chemico-biological interactions. 2022 Oct; 366(?):110149. doi: 10.1016/j.cbi.2022.110149. [PMID: 36084723]
  • Zhao Li, Kaikai Mao, Ruoheng Jin, Tingwei Cai, Yao Qin, Yunhua Zhang, Shun He, Kangsheng Ma, Hu Wan, Xuexiang Ren, Jianhong Li. miRNA novel_268 targeting NlABCG3 is involved in nitenpyram and clothianidin resistance in Nilaparvata lugens. International journal of biological macromolecules. 2022 Sep; 217(?):615-623. doi: 10.1016/j.ijbiomac.2022.07.096. [PMID: 35853504]
  • Demet Dogan, Gokhan Nur, Haci Ahmet Deveci. Tissue-specific toxicity of clothianidin on rainbow trout (Oncorhynchus mykiss). Drug and chemical toxicology. 2022 Jul; 45(4):1851-1861. doi: 10.1080/01480545.2021.1892128. [PMID: 33641563]
  • Chunni Zhang, Shaokai Du, Ruifang Liu, Wu Dai. Overexpression of Multiple Cytochrome P450 Genes Conferring Clothianidin Resistance in Bradysia odoriphaga. Journal of agricultural and food chemistry. 2022 Jun; 70(25):7636-7643. doi: 10.1021/acs.jafc.2c01315. [PMID: 35709533]
  • Yanmei Yang, Shu Qin, Xia Wang, Junli Cao, Jindong Li. Dissipation Behavior and Acute Dietary Risk Assessment of Thiamethoxam and Its Metabolite Clothianidin on Spinach. Molecules (Basel, Switzerland). 2022 Mar; 27(7):. doi: 10.3390/molecules27072209. [PMID: 35408608]
  • Tianyang You, Yuan Ding, He Chen, Guangyue Song, Lianrun Huang, Minghua Wang, Xiude Hua. Development of competitive and noncompetitive immunoassays for clothianidin with high sensitivity and specificity using phage-displayed peptides. Journal of hazardous materials. 2022 03; 425(?):128011. doi: 10.1016/j.jhazmat.2021.128011. [PMID: 34896720]
  • Kai-Long Li, Wu-Ying Chen, Min Zhang, Xiang-Wen Luo, Yong Liu, De-Yong Zhang, Ang Chen. Monitoring residue levels and dietary risk assessment of thiamethoxam and its metabolite clothianidin for Chinese consumption of Chinese kale. Journal of the science of food and agriculture. 2022 Jan; 102(1):417-424. doi: 10.1002/jsfa.11371. [PMID: 34143904]
  • Lina Herbertsson, Björn K Klatt, Maria Blasi, Maj Rundlöf, Henrik G Smith. Seed-coating of rapeseed (Brassica napus) with the neonicotinoid clothianidin affects behaviour of red mason bees (Osmia bicornis) and pollination of strawberry flowers (Fragaria × ananassa). PloS one. 2022; 17(9):e0273851. doi: 10.1371/journal.pone.0273851. [PMID: 36074788]
  • Kumiko Taira, Tomonori Kawakami, Sujithra Kaushaliya Weragoda, H M Ayala S Herath, Yoshinori Ikenaka, Kazutoshi Fujioka, Madhubhani Hemachandra, Nirmalie Pallewatta, Yoshiko Aoyama, Mayumi Ishizuka, Jean-Marc Bonmatin, Makiko Komori. Urinary concentrations of neonicotinoid insecticides were related to renal tubular dysfunction and neuropsychological complaints in Dry-zone of Sri Lanka. Scientific reports. 2021 11; 11(1):22484. doi: 10.1038/s41598-021-01732-2. [PMID: 34795341]
  • Yongfei Guo, Lirui Ren, Xiaolong Li, Zhao Wang, Yanning Zhang, Shuai Zhang, Tao Tang, Fuliang Chen, Fengpei Du. Bio-based clothianidin-loaded solid dispersion using composite carriers to improve efficacy and reduce environmental toxicity. Pest management science. 2021 Nov; 77(11):5246-5254. doi: 10.1002/ps.6567. [PMID: 34310012]
  • Yanhua Wang, Yu-Cheng Zhu, Wenhong Li, Jianxiu Yao, Gadi V P Reddy, Lu Lv. Binary and ternary toxicological interactions of clothianidin and eight commonly used pesticides on honey bees (Apis mellifera). Ecotoxicology and environmental safety. 2021 Oct; 223(?):112563. doi: 10.1016/j.ecoenv.2021.112563. [PMID: 34343900]
  • Ruoheng Jin, Yue Wang, Biyan He, Yunhua Zhang, Tingwei Cai, Hu Wan, Byung Rae Jin, Jianhong Li. Activator protein-1 mediated CYP6ER1 overexpression in the clothianidin resistance of Nilaparvata lugens (Stål). Pest management science. 2021 Oct; 77(10):4476-4482. doi: 10.1002/ps.6482. [PMID: 34010497]
  • Malin Røyset Aarønes, Julie Sørlie Paus-Knudsen, Anders Nielsen, Jan Thomas Rundberget, Katrine Borgå. Within-Body Distributions and Feeding Effects of the Neonicotinoid Insecticide Clothianidin in Bumblebees (Bombus terrestris). Environmental toxicology and chemistry. 2021 10; 40(10):2781-2790. doi: 10.1002/etc.5154. [PMID: 34236107]
  • Yunhua Zhang, Chaoya Liu, Ruoheng Jin, Yue Wang, Tingwei Cai, Zhijie Ren, Kangsheng Ma, Shun He, Kwang S Lee, Byung R Jin, Jianhong Li, Hu Wan. Dual oxidase-dependent reactive oxygen species are involved in the regulation of UGT overexpression-mediated clothianidin resistance in the brown planthopper, Nilaparvata lugens. Pest management science. 2021 Sep; 77(9):4159-4167. doi: 10.1002/ps.6453. [PMID: 33934482]
  • Tingting Liu, Jian Luo, Shangke Liu, Tongtong Li, Haolin Li, Lingyan Zhang, Wei Mu, Nan Zou. Clothianidin loaded TA/Fe (III) controlled-release granules: improve pesticide bioavailability and alleviate oxidative stress. Journal of hazardous materials. 2021 08; 416(?):125861. doi: 10.1016/j.jhazmat.2021.125861. [PMID: 34492809]
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