Tobramycin (BioDeep_00000002096)

 

Secondary id: BioDeep_00000406894

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


(2S,3R,4S,5S,6R)-4-amino-2-{[(1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2R,3R,5S,6R)-3-amino-6-(aminomethyl)-5-hydroxyoxan-2-yl]oxy}-2-hydroxycyclohexyl]oxy}-6-(hydroxymethyl)oxane-3,5-diol

化学式: C18H37N5O9 (467.2591152)
中文名称: 托普霉素
谱图信息: 最多检出来源 Homo sapiens(blood) 4.04%

分子结构信息

SMILES: C1C(C(C(C(C1N)OC2C(C(C(C(O2)CO)O)N)O)O)OC3C(CC(C(O3)CN)O)N)N
InChI: InChI=1S/C18H37N5O9/c19-3-9-8(25)2-7(22)17(29-9)31-15-5(20)1-6(21)16(14(15)28)32-18-13(27)11(23)12(26)10(4-24)30-18/h5-18,24-28H,1-4,19-23H2/t5-,6+,7+,8-,9+,10+,11-,12+,13+,14-,15+,16-,17+,18+/m0/s1

描述信息

Tobramycin is only found in individuals that have used or taken this drug. It is an aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the pseudomonas species. It is a 10\\\% component of the antibiotic complex, nebramycin, produced by the same species. [PubChem]Tobramycin binds irreversibly to one of two aminoglycoside binding sites on the 30 S ribosomal subunit, inhibiting bacterial protein synthesis. Tobramycin may also destabilize bacterial memebrane by binding to 16 S 16 S r-RNA. An active transport mechanism for aminoglycoside uptake is necessary in the bacteria in order to attain a significant intracellular concentration of tobramycin.
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01G - Aminoglycoside antibacterials
S - Sensory organs > S01 - Ophthalmologicals > S01A - Antiinfectives > S01AA - Antibiotics
C784 - Protein Synthesis Inhibitor > C2363 - Aminoglycoside Antibiotic
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
C254 - Anti-Infective Agent > C258 - Antibiotic
Tobramycin (Nebramycin Factor 6) is a parenterally administered, broad spectrum aminoglycoside antibiotic that is widely used in the treatment of moderate to severe bacterial infections due to sensitive organisms[1].Tobramycin can be used to pneumonia research caused by Pseudomonas aeruginosa[2][3].

同义名列表

24 个代谢物同义名

(2S,3R,4S,5S,6R)-4-amino-2-{[(1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2R,3R,5S,6R)-3-amino-6-(aminomethyl)-5-hydroxyoxan-2-yl]oxy}-2-hydroxycyclohexyl]oxy}-6-(hydroxymethyl)oxane-3,5-diol; O-3-Amino-3-deoxy-alpha-D-glucopyranosyl-(1-4)-O-(2,6-diamino-2,3,6-trideoxy-alpha-D-ribohexopyranosyl-(1-4))-2-deoxy-D-streptamine; O-3-Amino-3-deoxy-a-D-glucopyranosyl-(1-4)-O-(2,6-diamino-2,3,6-trideoxy-a-D-ribohexopyranosyl-(1-4))-2-deoxy-D-streptamine; O-3-Amino-3-deoxy-α-D-glucopyranosyl-(1-4)-O-(2,6-diamino-2,3,6-trideoxy-α-D-ribohexopyranosyl-(1-4))-2-deoxy-D-streptamine; Tobramycin solution for inhalation; Nebramycin factor 6; Nebramycin factir 6; Sulfate, tobramycin; 3-Deoxykanamycin b; Tobramycin sulfate; Tenebrimycin; Nebramycin 6; Brulamycin; Tobramycin; SPRC-AB01; Tobracin; Bethkis; Nebicin; Obracin; Tobrex; Nebcin; Tobi; TOB; Deoxykanamycin B



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

9 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Xianwen Xiao, Yuan Lin, Xie Fang, Zhiwen Xie, Shunrong Luo, Huping Wu. Clinical features and comprehensive treatment of persistent corneal epithelial dysfunction after cataract surgery. BMC ophthalmology. 2024 Apr; 24(1):197. doi: 10.1186/s12886-024-03466-x. [PMID: 38671418]
  • Jiaojiao Fu, Fangting He, Jinming Xiao, Zhengyue Liao, Liying He, Jing He, Jinlin Guo, Sijing Liu. Rapid AMR prediction in Pseudomonas aeruginosa combining MALDI-TOF MS with DNN model. Journal of applied microbiology. 2023 Nov; 134(11):. doi: 10.1093/jambio/lxad248. [PMID: 37930836]
  • Aleksandra Gostyńska, Katarzyna Dettlaff, Anna Jelińska, Maciej Stawny. Improving the Safety of Clinical Management of COVID-19 Patients Receiving Aminoglycosides and Parenteral Nutrition: Y-site Compatibility Studies. Journal of pharmaceutical sciences. 2023 10; 112(10):2597-2603. doi: 10.1016/j.xphs.2023.08.007. [PMID: 37595749]
  • Santhni Subramaniam, Paul Joyce, Clive A Prestidge. Liquid crystalline lipid nanoparticles improve the antibacterial activity of tobramycin and vancomycin against intracellular Pseudomonas aeruginosa and Staphylococcus aureus. International journal of pharmaceutics. 2023 Apr; 639(?):122927. doi: 10.1016/j.ijpharm.2023.122927. [PMID: 37059243]
  • Wenjuan Liu, Minglong Yan, Wenjie Zhao. Antibacterial-renew dual-function anti-biofouling strategy: Self-assembled Schiff-base metal complex coatings built from natural products. Journal of colloid and interface science. 2023 Jan; 629(Pt A):496-507. doi: 10.1016/j.jcis.2022.08.178. [PMID: 36088695]
  • Noelia Perez, María Julia Altube, Leandro Ramos Souza Barbosa, Eder Lilia Romero, Ana Paula Perez. Thymus vulgaris essential oil + tobramycin within nanostructured archaeolipid carriers: A new approach against Pseudomonas aeruginosa biofilms. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Jul; 102(?):154179. doi: 10.1016/j.phymed.2022.154179. [PMID: 35671606]
  • Christian Emmanuel Mahavy, Adeline Mol, Blandine Andrianarisoa, Pierre Duez, Mondher El Jaziri, Marie Baucher, Tsiry Rasamiravaka. The Xanthophyll Carotenoid Lutein Reduces the Invasive Potential of Pseudomonas aeruginosa and Increases Its Susceptibility to Tobramycin. International journal of molecular sciences. 2022 Jun; 23(13):. doi: 10.3390/ijms23137199. [PMID: 35806201]
  • Mehdi El Hassani, Chantale Simard, Sylvie Pilote, Isabelle Cloutier, Sara Soufsaf, Amélie Marsot. Consideration of height-based tobramycin dosing regimens for the treatment of adult cystic fibrosis pulmonary exacerbations. British journal of clinical pharmacology. 2022 05; 88(5):2246-2255. doi: 10.1111/bcp.15154. [PMID: 34820875]
  • Chelsea R Thorn, Anthony Wignall, Zlatko Kopecki, Anita Kral, Clive A Prestidge, Nicky Thomas. Liquid Crystal Nanoparticles Enhance Tobramycin Efficacy in a Murine Model of Pseudomonas aeruginosa Biofilm Wound Infection. ACS infectious diseases. 2022 04; 8(4):841-854. doi: 10.1021/acsinfecdis.1c00606. [PMID: 35255215]
  • Chie Inoue, Hideharu Hagiya. Anti-Glomerular Basement Membrane Nephritis Potentially Induced by Nebulized Tobramycin Inhalation. Journal of aerosol medicine and pulmonary drug delivery. 2022 04; 35(2):104-106. doi: 10.1089/jamp.2021.0053. [PMID: 34870476]
  • Roxane Rohani, Brian Hoff, Manu Jain, Alexander Philbrick, Sara Salama, Joanne F Cullina, Nathaniel J Rhodes. Defining the Importance of Age-Related Changes in Drug Clearance to Optimizing Aminoglycoside Dosing Regimens for Adult Patients with Cystic Fibrosis. European journal of drug metabolism and pharmacokinetics. 2022 Mar; 47(2):199-209. doi: 10.1007/s13318-021-00734-9. [PMID: 34882292]
  • Jacob P Counts, Jessica L Elefritz, Erica E Reed, Marilly Palettas, Connor Aossey, Julia J Beatty. Risk Factors Associated with Suboptimal Tobramycin Levels in the Medical Intensive Care Unit. European journal of drug metabolism and pharmacokinetics. 2022 Mar; 47(2):271-278. doi: 10.1007/s13318-021-00749-2. [PMID: 35029839]
  • Parisa Tavakoli, Seyed Mohammad Taghdisi, Parvaneh Maghami, Khalil Abnous. A novel aptasensor for colorimetric monitoring of tobramycin: Strategy of enzyme-like activity of AuNPs controlled by three-way junction DNA pockets. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2022 Feb; 267(Pt 2):120626. doi: 10.1016/j.saa.2021.120626. [PMID: 34815175]
  • Han-Wen Zhang, Hong-Kai Li, Zhang-Ye Han, Rongrong Yuan, Hongming He. Incorporating Fullerenes in Nanoscale Metal-Organic Matrixes: An Ultrasensitive Platform for Impedimetric Aptasensing of Tobramycin. ACS applied materials & interfaces. 2022 Feb; 14(5):7350-7357. doi: 10.1021/acsami.1c23320. [PMID: 35076206]
  • Joseph Jeffry Borick, Shuba Balan, Paola Lichtenberger, Lauren Bjork. Timely explantation of tobramycin-impregnated beads and bone cement to avoid haemodialysis in a patient with worsening renal failure. BMJ case reports. 2022 Feb; 15(2):. doi: 10.1136/bcr-2021-242760. [PMID: 35131767]
  • Scott Marston, Gudrun Mirick Mueller, Arick Sabin, Glen T Hansen, Bruce Lindgren, Conrado Aparicio, Alexandra R Armstrong, Ole H Larsen, Andrew Schmidt, Richard Kyle, Ramon Gustilo, Dean Tsukayama, Joan Bechtold, Mats Bue. Systemic versus free antibiotic delivery in preventing acute exogenous implant related infection in a rat model. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2022 02; 40(2):429-438. doi: 10.1002/jor.25052. [PMID: 33913540]
  • Yi-Zhong Gu, Larry Handt, Katerina Vlasakova, Vasudevan Bakthavatchalu, Roger Smith, Guillermo E Fernandez, Stephanie L Born, Warren E Glaab, Frank D Sistare. Kidney Injury Monitoring in Tobramycin-Treated Rhesus Monkeys: Supplementing Urinary Kidney Biomarkers With Kidney Biopsy Gene Expression Profiling. Toxicologic pathology. 2022 01; 50(1):35-46. doi: 10.1177/01926233211049171. [PMID: 34657537]
  • Charles Murray Lawrie, Gregory S Kazarian, Toby Barrack, Ryan M Nunley, Robert L Barrack. Intra-articular administration of vancomycin and tobramycin during primary cementless total knee arthroplasty : determination of intra-articular and serum elution profiles. The bone & joint journal. 2021 Nov; 103-B(11):1702-1708. doi: 10.1302/0301-620x.103b11.bjj-2020-2453.r1. [PMID: 34719272]
  • Katja Becker, Sha Cao, Anna Nilsson, Maria Erlandsson, Sven-Kevin Hotop, Janis Kuka, Jon Hansen, Klara Haldimann, Solveiga Grinberga, Talia Berruga-Fernández, Douglas L Huseby, Reza Shariatgorji, Evelina Lindmark, Björn Platzack, Erik C Böttger, David Crich, Lena E Friberg, Carina Vingsbo Lundberg, Diarmaid Hughes, Mark Brönstrup, Per E Andrén, Edgars Liepinsh, Sven N Hobbie. Antibacterial activity of apramycin at acidic pH warrants wide therapeutic window in the treatment of complicated urinary tract infections and acute pyelonephritis. EBioMedicine. 2021 Nov; 73(?):103652. doi: 10.1016/j.ebiom.2021.103652. [PMID: 34740109]
  • Katherine B Landmesser, Elizabeth B Autry, Brian M Gardner, Katherine A Bosko, Aric Schadler, Robert J Kuhn. Comparison of the predictive value of area under the curve versus maximum serum concentration of intravenous tobramycin in cystic fibrosis patients treated for an acute pulmonary exacerbation. Pediatric pulmonology. 2021 10; 56(10):3209-3216. doi: 10.1002/ppul.25569. [PMID: 34241975]
  • Sawsan M A El-Sheikh, Abd El-Alim F Abd El-Alim, Hosny A Ibrahim, Elham A Mobarez, Walaa A El-Sayed, Azza A A Galal, Naglaa F S Awad. Chitosan propolis nanocomposite alone or in combination with apramycin: an alternative therapy for multidrug-resistant Salmonella Typhimurium in rabbits: in vitro and in vivo study. Journal of medical microbiology. 2021 Oct; 70(10):. doi: 10.1099/jmm.0.001412. [PMID: 34612810]
  • Katja Becker, Vincent Aranzana-Climent, Sha Cao, Anna Nilsson, Reza Shariatgorji, Klara Haldimann, Björn Platzack, Diarmaid Hughes, Per E Andrén, Erik C Böttger, Lena E Friberg, Sven N Hobbie. Efficacy of EBL-1003 (apramycin) against Acinetobacter baumannii lung infections in mice. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. 2021 Sep; 27(9):1315-1321. doi: 10.1016/j.cmi.2020.12.004. [PMID: 33316399]
  • Chelsea R Thorn, Cristiane de Souza Carvalho-Wodarz, Justus C Horstmann, Claus-Michael Lehr, Clive A Prestidge, Nicky Thomas. Tobramycin Liquid Crystal Nanoparticles Eradicate Cystic Fibrosis-Related Pseudomonas aeruginosa Biofilms. Small (Weinheim an der Bergstrasse, Germany). 2021 06; 17(24):e2100531. doi: 10.1002/smll.202100531. [PMID: 33978317]
  • Louis Dagneaux, Afton K Limberg, Douglas R Osmon, Nelson Leung, Daniel J Berry, Matthew P Abdel. Acute Kidney Injury When Treating Periprosthetic Joint Infections After Total Knee Arthroplasties with Antibiotic-Loaded Spacers: Incidence, Risks, and Outcomes. The Journal of bone and joint surgery. American volume. 2021 05; 103(9):754-760. doi: 10.2106/jbjs.20.01825. [PMID: 33780403]
  • Steven L Taylor, Lex E X Leong, Sarah K Sims, Rebecca L Keating, Lito E Papanicolas, Alyson Richard, Fredrick M Mobegi, Steve Wesselingh, Lucy D Burr, Geraint B Rogers. The cystic fibrosis gut as a potential source of multidrug resistant pathogens. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. 2021 05; 20(3):413-420. doi: 10.1016/j.jcf.2020.11.009. [PMID: 33250435]
  • Constanza Toledo, Rocío C Gambaro, Gisel Padula, María E Vela, Guillermo R Castro, Cecilia Y Chain, Germán A Islan. Binary Medical Nanofluids by Combination of Polymeric Eudragit Nanoparticles for Vehiculization of Tobramycin and Resveratrol: Antimicrobial, Hemotoxicity and Protein Corona Studies. Journal of pharmaceutical sciences. 2021 04; 110(4):1739-1748. doi: 10.1016/j.xphs.2021.01.005. [PMID: 33428918]
  • Tomás Sou, Jon Hansen, Edgars Liepinsh, Maria Backlund, Onur Ercan, Solveiga Grinberga, Sha Cao, Paraskevi Giachou, Anna Petersson, Magdalena Tomczak, Malgorzata Urbas, Dorota Zabicka, Carina Vingsbo Lundberg, Diarmaid Hughes, Sven N Hobbie, Lena E Friberg. Model-Informed Drug Development for Antimicrobials: Translational PK and PK/PD Modeling to Predict an Efficacious Human Dose for Apramycin. Clinical pharmacology and therapeutics. 2021 04; 109(4):1063-1073. doi: 10.1002/cpt.2104. [PMID: 33150591]
  • Jayesh A Dhanani, Steven Goodman, Benjamin Ahern, Jeremy Cohen, John F Fraser, Adrian Barnett, Sara Diab, Manoj Bhatt, Jason A Roberts. Comparative lung distribution of radiolabeled tobramycin between nebulized and intravenous administration in a mechanically-ventilated ovine model, an observational study. International journal of antimicrobial agents. 2021 Feb; 57(2):106232. doi: 10.1016/j.ijantimicag.2020.106232. [PMID: 33232733]
  • Zeren Liang, Kai Gao, Mengdi Lu, Wei Peng, Shenggeng Zhu, Yixiu Huang, Long Hong, Jean-Francois Masson. Comparative study of serum sample preparation methods in aggregation-based plasmonic sensing. The Analyst. 2021 Jan; 145(24):7946-7955. doi: 10.1039/d0an01348j. [PMID: 33034308]
  • John M Morrison, Michaelle Chojnacki, Jeffrey J Fadrowski, Colleen Bauza, Paul M Dunman, Robert A Dudas, Neil A Goldenberg, David M Berman. Serum-Associated Antibiotic Tolerance in Pediatric Clinical Isolates of Pseudomonas aeruginosa. Journal of the Pediatric Infectious Diseases Society. 2020 Dec; 9(6):671-679. doi: 10.1093/jpids/piz094. [PMID: 31886511]
  • Traci M Grucz, Rachel M Kruer, Fidelia Bernice, Pamela A Lipsett, Todd Dorman, David Sugrue, Andrew S Jarrell. Aminoglycoside Dosing and Volume of Distribution in Critically Ill Surgery Patients. Surgical infections. 2020 Dec; 21(10):859-864. doi: 10.1089/sur.2020.012. [PMID: 32302517]
  • Anasemon Saad, McKenzie R Young, Anna E Studtmann, Elizabeth B Autry, Aric Schadler, Elizabeth J Beckman, Brian M Gardner, Mark A Wurth, Robert J Kuhn. Incidence of nephrotoxicity with prolonged aminoglycoside exposure in patients with cystic fibrosis. Pediatric pulmonology. 2020 12; 55(12):3384-3390. doi: 10.1002/ppul.25066. [PMID: 32910553]
  • Paul Skorup, Lisa Maudsdotter, Miklós Lipcsey, Anders Larsson, Jan Sjölin. Mode of bacterial killing affects the inflammatory response and associated organ dysfunctions in a porcine E. coli intensive care sepsis model. Critical care (London, England). 2020 11; 24(1):646. doi: 10.1186/s13054-020-03303-9. [PMID: 33189146]
  • Lars Christophersen, Franziska Angelika Schwartz, Christian Johann Lerche, Trine Svanekjær, Kasper Nørskov Kragh, Anne Sofie Laulund, Kim Thomsen, Kaj-Åge Henneberg, Thomas Sams, Niels Høiby, Claus Moser. In vivo demonstration of Pseudomonas aeruginosa biofilms as independent pharmacological microcompartments. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. 2020 11; 19(6):996-1003. doi: 10.1016/j.jcf.2020.01.009. [PMID: 32067957]
  • Mengya Li, Lingyun Ma, Chaoyang Chen, Lili Lei, Xingyu Zhai, Daohuang Luo, Ying Zhou, Yimin Cui. Evaluation of Assays to Measure Aminoglycosides in Serum: Comparison of Accuracy and Precision Based on External Quality Assessment. Therapeutic drug monitoring. 2020 10; 42(5):710-715. doi: 10.1097/ftd.0000000000000752. [PMID: 32118804]
  • Man Zhu, Shaoguang Li, Hongxing Li, Hui Li, Fan Xia. Employing an Intercalated Redox Reporter in Electrochemical Aptamer-Based Biosensors to Enable Calibration-Free Molecular Measurements in Undiluted Serum. Analytical chemistry. 2020 09; 92(18):12437-12441. doi: 10.1021/acs.analchem.0c02205. [PMID: 32786211]
  • Yuqi Yang, Tianshi Xiao, Jiarui Li, Ping Cheng, Fulei Li, Hongxiao Yu, Ruimeng Liu, Ishfaq Muhammad, Xiuying Zhang. Wild-type cutoff for Apramycin against Escherichia coli. BMC veterinary research. 2020 Aug; 16(1):309. doi: 10.1186/s12917-020-02522-0. [PMID: 32847547]
  • Erik M van Maarseveen, Renske van der Meer, Cees Neef, Harry G M Heijerman, Daniel J Touw. Does Circadian Rhythm Affect the Pharmacokinetics of Once-Daily Tobramycin in Adults With Cystic Fibrosis?. Therapeutic drug monitoring. 2020 08; 42(4):595-599. doi: 10.1097/ftd.0000000000000743. [PMID: 32049889]
  • Gerhard E Maale, John J Eager, Daniel K Mohammadi, Flavio A Calderon. Elution Profiles of Synthetic CaSO4 Hemihydrate Beads Loaded with Vancomycin and Tobramycin. European journal of drug metabolism and pharmacokinetics. 2020 Aug; 45(4):547-555. doi: 10.1007/s13318-020-00622-8. [PMID: 32328932]
  • Chiara Rezzoagli, Martina Archetti, Ingrid Mignot, Michael Baumgartner, Rolf Kümmerli. Combining antibiotics with antivirulence compounds can have synergistic effects and reverse selection for antibiotic resistance in Pseudomonas aeruginosa. PLoS biology. 2020 08; 18(8):e3000805. doi: 10.1371/journal.pbio.3000805. [PMID: 32810152]
  • Coral García-Gutiérrez, Tomás Aparicio, Lucía Torres-Sánchez, Esteban Martínez-García, Víctor de Lorenzo, Claudio J Villar, Felipe Lombó. Multifunctional SEVA shuttle vectors for actinomycetes and Gram-negative bacteria. MicrobiologyOpen. 2020 06; 9(6):1135-1149. doi: 10.1002/mbo3.1024. [PMID: 32170856]
  • Brian M Hoff, Marc H Scheetz, Manu Jain, Joanne F Cullina, Nathaniel J Rhodes. Exploring the Relationship between FEV1 Loss and Recovery and Aminoglycoside Pharmacokinetics in Adult Patients with Cystic Fibrosis: Implications for Clinical Dosing Strategies. Pharmacotherapy. 2020 06; 40(6):584-591. doi: 10.1002/phar.2399. [PMID: 32259317]
  • Wei-Jia Cheng, Jin-Wei Zhou, Ping-Ping Zhang, Huai-Zhi Luo, Shi Tang, Jun-Jian Li, Shi-Ming Deng, Ai-Qun Jia. Quorum sensing inhibition and tobramycin acceleration in Chromobacterium violaceum by two natural cinnamic acid derivatives. Applied microbiology and biotechnology. 2020 Jun; 104(11):5025-5037. doi: 10.1007/s00253-020-10593-0. [PMID: 32248442]
  • Tomás Sou, Irena Kukavica-Ibrulj, Roger C Levesque, Lena E Friberg, Christel A S Bergström. Model-Informed Drug Development in Pulmonary Delivery: Semimechanistic Pharmacokinetic-Pharmacodynamic Modeling for Evaluation of Treatments against Chronic Pseudomonas aeruginosa Lung Infections. Molecular pharmaceutics. 2020 05; 17(5):1458-1469. doi: 10.1021/acs.molpharmaceut.9b00968. [PMID: 31951139]
  • Julie A Lawrence, Zhongping Huang, Sivaprakash Rathinavelu, Jin-Feng Hu, Eliane Garo, Michael Ellis, Vanessa L Norman, Ronald Buckle, Russell B Williams, Courtney M Starks, Gary R Eldridge. Optimized plant compound with potent anti-biofilm activity across gram-negative species. Bioorganic & medicinal chemistry. 2020 03; 28(5):115229. doi: 10.1016/j.bmc.2019.115229. [PMID: 32033878]
  • Sivan Louzoun Zada, Bar Ben Baruch, Luba Simhaev, Hamutal Engel, Micha Fridman. Chemical Modifications Reduce Auditory Cell Damage Induced by Aminoglycoside Antibiotics. Journal of the American Chemical Society. 2020 02; 142(6):3077-3087. doi: 10.1021/jacs.9b12420. [PMID: 31958945]
  • Stephen J McWilliam, Anna Rosala-Hallas, Ashley P Jones, Victoria Shaw, William Greenhalf, Thomas Jaki, Alan R Smyth, Rosalind L Smyth, Munir Pirmohamed. A randomised controlled trial of rosuvastatin for the prevention of aminoglycoside-induced kidney toxicity in children with cystic fibrosis. Scientific reports. 2020 02; 10(1):1796. doi: 10.1038/s41598-020-58790-1. [PMID: 32020028]
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  • Saurabh Pandey, Jayesh Dhanani, Jeffrey Lipman, Jason A Roberts, Steve C Wallis, Suzanne L Parker. Development and validation of LC-MS/MS methods to measure tobramycin and lincomycin in plasma, microdialysis fluid and urine: application to a pilot pharmacokinetic research study. Clinical chemistry and laboratory medicine. 2020 01; 58(2):274-284. doi: 10.1515/cclm-2019-0780. [PMID: 31714883]
  • Matthijs D Kruizinga, Willem A J Birkhoff, Michiel J van Esdonk, Naomi B Klarenbeek, Tomasz Cholewinski, Tessa Nelemans, Melloney J Dröge, Adam F Cohen, Rob G J A Zuiker. Pharmacokinetics of intravenous and inhaled salbutamol and tobramycin: An exploratory study to investigate the potential of exhaled breath condensate as a matrix for pharmacokinetic analysis. British journal of clinical pharmacology. 2020 01; 86(1):175-181. doi: 10.1111/bcp.14156. [PMID: 31658494]
  • Jonathon R Lindner, David Seligson, Ernest Chisena, Saeed A Jortani, Erik A Korte. Does an antibiotic nail made in a lubricated tube release antibiotic?. European journal of orthopaedic surgery & traumatology : orthopedie traumatologie. 2020 Jan; 30(1):153-156. doi: 10.1007/s00590-019-02533-0. [PMID: 31471738]
  • Sean N Avedissian, Nathaniel J Rhodes, Yuna Kim, John Bradley, Joshua L Valdez, Jennifer Le. Augmented renal clearance of aminoglycosides using population-based pharmacokinetic modelling with Bayesian estimation in the paediatric ICU. The Journal of antimicrobial chemotherapy. 2020 01; 75(1):162-169. doi: 10.1093/jac/dkz408. [PMID: 31648297]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
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