alpha-Solanine (BioDeep_00000002014)

   

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite


代谢物信息卡片


alpha-Solanine

化学式: C45H73NO15 (867.4979947999999)
中文名称: α-茄碱
谱图信息: 最多检出来源 Viridiplantae(plant) 0.56%

Reviewed

Last reviewed on 2024-07-24.

Cite this Page

alpha-Solanine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/alpha-solanine (retrieved 2024-11-15) (BioDeep RN: BioDeep_00000002014). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CC1CCC2C(C)C3C(CC4C5CC=C6CC(OC7OC(CO)C(O)C(OC8OC(CO)C(O)C(O)C8O)C7OC7OC(C)C(O)C(O)C7O)CCC6(C)C5CCC43C)N2C1
InChI: InChI=1S/C45H73NO15/c1-19-6-9-27-20(2)31-28(46(27)16-19)15-26-24-8-7-22-14-23(10-12-44(22,4)25(24)11-13-45(26,31)5)57-43-40(61-41-37(54)35(52)32(49)21(3)56-41)39(34(51)30(18-48)59-43)60-42-38(55)36(53)33(50)29(17-47)58-42/h7,19-21,23-43,47-55H,6,8-18H2,1-5H3

描述信息

[Raw Data] CB083_Solanine_pos_30eV_isCID-10eV_rep000003.txt
[Raw Data] CB083_Solanine_pos_40eV_isCID-10eV_rep000003.txt
[Raw Data] CB083_Solanine_pos_50eV_isCID-10eV_rep000003.txt
[Raw Data] CB083_Solanine_pos_20eV_isCID-10eV_rep000003.txt
[Raw Data] CB083_Solanine_pos_10eV_isCID-10eV_rep000003.txt
α-solanine, a bioactive component and one of the major steroidal glycoalkaloids in Solanum nigrum, has been observed to inhibit growth and induce apoptosis in cancer cells[1].
α-solanine, a bioactive component and one of the major steroidal glycoalkaloids in Solanum nigrum, has been observed to inhibit growth and induce apoptosis in cancer cells[1].

同义名列表

4 个代谢物同义名

alpha-Solanine; alpha-Solanin; α-Solanine; Solanine



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

4 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jinyi Zhou, Jinting Wu, Fangda Fu, Sai Yao, Wenbiao Zheng, Weibin Du, Huan Luo, Hongting Jin, Peijian Tong, Chengliang Wu, Hongfeng Ruan. α-Solanine attenuates chondrocyte pyroptosis to improve osteoarthritis via suppressing NF-κB pathway. Journal of cellular and molecular medicine. 2024 Feb; 28(4):e18132. doi: 10.1111/jcmm.18132. [PMID: 38345195]
  • Xudong Ma, Yijun Li, Daoming Liang, Fan Jiang, Lu Zhang, Wanhong Song, Baosheng Wan, Chuqi Xia, Qiyu Lu. Solanine induces ferroptosis in colorectal cancer cells through ALOX12B/ADCY4 molecular axis. The Journal of pharmacy and pharmacology. 2024 Jan; ?(?):. doi: 10.1093/jpp/rgad122. [PMID: 38244223]
  • Xiaolong Tang, YingYing Guo, Sijia Zhang, Xin Wang, Yuhao Teng, Qingjiang Jin, Qinglei Jin, Wei Shen, Ruiping Wang. Solanine Represses Gastric Cancer Growth by Mediating Autophagy Through AAMDC/MYC/ATF4/Sesn2 Signaling Pathway. Drug design, development and therapy. 2023; 17(?):389-402. doi: 10.2147/dddt.s389764. [PMID: 36789094]
  • Przemysław Łukasz Kowalczewski, Anna Olejnik, Martyna Natalia Wieczorek, Joanna Zembrzuska, Katarzyna Kowalska, Jacek Lewandowicz, Grażyna Lewandowicz. Bioactive Substances of Potato Juice Reveal Synergy in Cytotoxic Activity against Cancer Cells of Digestive System Studied In Vitro. Nutrients. 2022 Dec; 15(1):. doi: 10.3390/nu15010114. [PMID: 36615771]
  • Sebastian Baur, Nicole Bellé, Hans Hausladen, Sebastian Wurzer, Laura Brehm, Timo D Stark, Ralph Hücklhoven, Thomas Hofmann, Corinna Dawid. Quantitation of Toxic Steroidal Glycoalkaloids and Newly Identified Saponins in Post-Harvest Light-Stressed Potato (Solanum tuberosum L.) Varieties. Journal of agricultural and food chemistry. 2022 Jul; 70(27):8300-8308. doi: 10.1021/acs.jafc.2c02578. [PMID: 35775364]
  • Shaimaa A Gouhar, Mahmoud T Abo-Elfadl, Amira M Gamal-Eldeen, Sherien M El-Daly. Involvement of miRNAs in response to oxidative stress induced by the steroidal glycoalkaloid α-solanine in hepatocellular carcinoma cells. Environmental toxicology. 2022 Feb; 37(2):212-223. doi: 10.1002/tox.23390. [PMID: 34655286]
  • Libin Wan, Haidong Gao, Huoliang Gao, Rui Du, Fayun Wang, Yong Wang, Mantang Chen. Selective extraction and determination of steroidal glycoalkaloids in potato tissues by electromembrane extraction combined with LC-MS/MS. Food chemistry. 2022 Jan; 367(?):130724. doi: 10.1016/j.foodchem.2021.130724. [PMID: 34352691]
  • Sebastian Baur, Oliver Frank, Hans Hausladen, Ralph Hückelhoven, Thomas Hofmann, Wolfgang Eisenreich, Corinna Dawid. Biosynthesis of α-solanine and α-chaconine in potato leaves (Solanum tuberosum L.) - A 13CO2 study. Food chemistry. 2021 Dec; 365(?):130461. doi: 10.1016/j.foodchem.2021.130461. [PMID: 34229992]
  • Ekta Bhattacharya, Suparna Mandal Biswas, Panchanan Pramanik. Maleic and L-tartaric acids as new anti-sprouting agents for potatoes during storage in comparison to other efficient sprout suppressants. Scientific reports. 2021 10; 11(1):20029. doi: 10.1038/s41598-021-99187-y. [PMID: 34625595]
  • Masaru Nakayasu, Naoyuki Umemoto, Ryota Akiyama, Kiyoshi Ohyama, Hyoung J Lee, Haruka Miyachi, Bunta Watanabe, Toshiya Muranaka, Kazuki Saito, Yukihiro Sugimoto, Masaharu Mizutani. Characterization of C-26 aminotransferase, indispensable for steroidal glycoalkaloid biosynthesis. The Plant journal : for cell and molecular biology. 2021 10; 108(1):81-92. doi: 10.1111/tpj.15426. [PMID: 34273198]
  • Ryota Akiyama, Bunta Watanabe, Masaru Nakayasu, Hyoung Jae Lee, Junpei Kato, Naoyuki Umemoto, Toshiya Muranaka, Kazuki Saito, Yukihiro Sugimoto, Masaharu Mizutani. The biosynthetic pathway of potato solanidanes diverged from that of spirosolanes due to evolution of a dioxygenase. Nature communications. 2021 02; 12(1):1300. doi: 10.1038/s41467-021-21546-0. [PMID: 33637735]
  • Miia J Rainio, Aigi Margus, Valtteri Virtanen, Leena Lindström, Juha-Pekka Salminen, Kari Saikkonen, Marjo Helander. Glyphosate-based herbicide has soil-mediated effects on potato glycoalkaloids and oxidative status of a potato pest. Chemosphere. 2020 Nov; 258(?):127254. doi: 10.1016/j.chemosphere.2020.127254. [PMID: 32559492]
  • Xia Yan, Miao Li, Lei Chen, Xiao Peng, Zu-Jun Que, Hong-Mei An, Ke-Ping Shen, Bing Hu. α‑Solanine inhibits growth and metastatic potential of human colorectal cancer cells. Oncology reports. 2020 05; 43(5):1387-1396. doi: 10.3892/or.2020.7519. [PMID: 32323807]
  • Rosanna C Hennessy, Søren D Nielsen, Mathias Greve-Poulsen, Lotte Bach Larsen, Ole Bandsholm Sørensen, Peter Stougaard. Discovery of a Bacterial Gene Cluster for Deglycosylation of Toxic Potato Steroidal Glycoalkaloids α-Chaconine and α-Solanine. Journal of agricultural and food chemistry. 2020 Feb; 68(5):1390-1396. doi: 10.1021/acs.jafc.9b07632. [PMID: 31935098]
  • Liang-Tzung Lin, Chen-Yen Choong, Chen-Jei Tai. Solanine Attenuated Hepatocarcinoma Migration and Invasion Induced by Acetylcholine. Integrative cancer therapies. 2020 Jan; 19(?):1534735420909895. doi: 10.1177/1534735420909895. [PMID: 32975458]
  • Weina Zhang, Cunwu Zuo, Zhongjian Chen, Yichen Kang, Shuhao Qin. RNA Sequencing Reveals That Both Abiotic and Biotic Stress-Responsive Genes are Induced during Expression of Steroidal Glycoalkaloid in Potato Tuber Subjected to Light Exposure. Genes. 2019 11; 10(11):. doi: 10.3390/genes10110920. [PMID: 31718041]
  • Bin Jia, Lixing Xu, Wenqiang Guan, Qiong Lin, Charles Brennan, Ruixiang Yan, Hui Zhao. Effect of citronella essential oil fumigation on sprout suppression and quality of potato tubers during storage. Food chemistry. 2019 Jun; 284(?):254-258. doi: 10.1016/j.foodchem.2019.01.119. [PMID: 30744854]
  • Rémi Beaulieu, Eric Grand, Imane Stasik, Jacques Attoumbré, Quentin Chesnais, Virginie Gobert, Arnaud Ameline, Philippe Giordanengo, José Kovensky. Synthesis and insecticidal activities of novel solanidine derivatives. Pest management science. 2019 Mar; 75(3):793-800. doi: 10.1002/ps.5180. [PMID: 30136365]
  • Masaru Nakayasu, Ryota Akiyama, Hyoung Jae Lee, Keishi Osakabe, Yuriko Osakabe, Bunta Watanabe, Yukihiro Sugimoto, Naoyuki Umemoto, Kazuki Saito, Toshiya Muranaka, Masaharu Mizutani. Generation of α-solanine-free hairy roots of potato by CRISPR/Cas9 mediated genome editing of the St16DOX gene. Plant physiology and biochemistry : PPB. 2018 Oct; 131(?):70-77. doi: 10.1016/j.plaphy.2018.04.026. [PMID: 29735370]
  • Xiaofen Ni, Jiajun Chen, Fengying Lu, Zhengzhong Yuan, Xiaofeng Xu, Zhen Hu, Lei Jiang. Anti-Cancer Effect of α-Solanine by Down-Regulating S100P Expression in Colorectal Cancer Cells. Recent patents on anti-cancer drug discovery. 2018; 13(2):240-247. doi: 10.2174/1574892813666180329163945. [PMID: 29600769]
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  • Anders Glynn, Annachiara Malin Igra, Salomon Sand, Nils Gunnar Ilbäck, Karl Erik Hellenäs, Johan Rosén, Bitte Aspenström-Fagerlund. Are additive effects of dietary surfactants on intestinal tight junction integrity an overlooked human health risk? - A mixture study on Caco-2 monolayers. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2017 Aug; 106(Pt A):314-323. doi: 10.1016/j.fct.2017.05.068. [PMID: 28576466]
  • Paul Dahlin, Marion C Müller, Sophia Ekengren, Lauren S McKee, Vincent Bulone. The Impact of Steroidal Glycoalkaloids on the Physiology of Phytophthora infestans, the Causative Agent of Potato Late Blight. Molecular plant-microbe interactions : MPMI. 2017 07; 30(7):531-542. doi: 10.1094/mpmi-09-16-0186-r. [PMID: 28510502]
  • Naoyuki Umemoto, Masaru Nakayasu, Kiyoshi Ohyama, Mari Yotsu-Yamashita, Masaharu Mizutani, Hikaru Seki, Kazuki Saito, Toshiya Muranaka. Two Cytochrome P450 Monooxygenases Catalyze Early Hydroxylation Steps in the Potato Steroid Glycoalkaloid Biosynthetic Pathway. Plant physiology. 2016 08; 171(4):2458-67. doi: 10.1104/pp.16.00137. [PMID: 27307258]
  • Louise Vida Traill Shepherd, Christine Anne Hackett, Colin James Alexander, James William McNicol, Julia Anne Sungurtas, Diane McRae, Kent Frank McCue, William Richardson Belknap, Howard Vivian Davies. Impact of light-exposure on the metabolite balance of transgenic potato tubers with modified glycoalkaloid biosynthesis. Food chemistry. 2016 Jun; 200(?):263-73. doi: 10.1016/j.foodchem.2015.12.095. [PMID: 26830588]
  • A F Sánchez-Maldonado, A Schieber, M G Gänzle. Antifungal activity of secondary plant metabolites from potatoes (Solanum tuberosum L.): Glycoalkaloids and phenolic acids show synergistic effects. Journal of applied microbiology. 2016 Apr; 120(4):955-65. doi: 10.1111/jam.13056. [PMID: 26786886]
  • Mohammad B Hossain, Nigel P Brunton, Dilip K Rai. Effect of Drying Methods on the Steroidal Alkaloid Content of Potato Peels, Shoots and Berries. Molecules (Basel, Switzerland). 2016 Mar; 21(4):403. doi: 10.3390/molecules21040403. [PMID: 27023503]
  • Roberta Fogliatto Mariot, Luisa Abruzzi de Oliveira, Marleen M Voorhuijzen, Martijn Staats, Ronald C B Hutten, Jeroen P van Dijk, Esther J Kok, Jeverson Frazzon. Characterization and Transcriptional Profile of Genes Involved in Glycoalkaloid Biosynthesis in New Varieties of Solanum tuberosum L. Journal of agricultural and food chemistry. 2016 Feb; 64(4):988-96. doi: 10.1021/acs.jafc.5b05519. [PMID: 26768994]
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