Iervin (BioDeep_00000002009)

 

Secondary id: BioDeep_00000230186

PANOMIX_OTCML-2023


代谢物信息卡片


Jervine

化学式: C27H39NO3 (425.29297840000004)
中文名称: 蒜藜芦碱, 蒜黎芦碱
谱图信息: 最多检出来源 Viridiplantae(plant) 5.56%

分子结构信息

SMILES: CC1=C2C(=O)C3C(CC=C4CC(O)CCC43C)C2CCC12OC1CC(C)CNC1C2C
InChI: InChI=1S/C27H39NO3/c1-14-11-21-24(28-13-14)16(3)27(31-21)10-8-19-20-6-5-17-12-18(29)7-9-26(17,4)23(20)25(30)22(19)15(27)2/h5,14,16,18-21,23-24,28-29H,6-13H2,1-4H3/t14-,16+,18-,19-,20-,21+,23+,24-,26-,27-/m0/s1

描述信息

D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents > D014704 - Veratrum Alkaloids
CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 2330
Jervine (11-Ketocyclopamine) is a potent Hedgehog (Hh) inhibitor with an IC50 of 500-700 nM[1]. Jervine is a natural teratogenic sterodial alkaloid from rhizomes of Veratrum nigrum. Jervine has anti-inflammatory and antioxidant properties[2].
Jervine (11-Ketocyclopamine) is a potent Hedgehog (Hh) inhibitor with an IC50 of 500-700 nM[1]. Jervine is a natural teratogenic sterodial alkaloid from rhizomes of Veratrum nigrum. Jervine has anti-inflammatory and antioxidant properties[2].

同义名列表

3 个代谢物同义名

Jervine; Iervin; 11-Ketocyclopamine



数据库引用编号

32 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Song Wang, Jiali Cui, Gaoqiong Zhao, Hongbin Liu, Jingkun Wang. Pharmacokinetics of Veratramine and Jervine from Alcohol Extracts of Radix Veratri. Computational and mathematical methods in medicine. 2022; 2022(?):8289548. doi: 10.1155/2022/8289548. [PMID: 35785141]
  • Yue Cong, Yantong Wu, Shan Shen, Xiping Liu, Jinggong Guo. A Structure-Activity Relationship between the Veratrum Alkaloids on the Antihypertension and DNA Damage Activity in Mice. Chemistry & biodiversity. 2020 Feb; 17(2):e1900473. doi: 10.1002/cbdv.201900473. [PMID: 31961474]
  • Fadime Atalay Dumlu, Tuba Aydin, Fehmi Odabasoglu, Ozlem Aydin Berktas, Zerrin Kutlu, Huseyin Serkan Erol, Mesut B Halici, Elif Cadirci, Ahmet Cakir. Anti-inflammatory and antioxidant properties of jervine, a sterodial alkaloid from rhizomes of Veratrum album. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2019 Mar; 55(?):191-199. doi: 10.1016/j.phymed.2018.06.035. [PMID: 30668429]
  • Elina Karhu, Janne Isojärvi, Pia Vuorela, Leena Hanski, Adyary Fallarero. Identification of Privileged Antichlamydial Natural Products by a Ligand-Based Strategy. Journal of natural products. 2017 10; 80(10):2602-2608. doi: 10.1021/acs.jnatprod.6b01052. [PMID: 29043803]
  • Kohei Kazuma, Katsuhiro Konno. [Poisoning by accidental ingestion of poisonous plants]. Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology. 2013 Jun; 26(2):97-101. doi: ". [PMID: 23855239]
  • Lamia Ghezali, David Yannick Leger, Youness Limami, Jeanne Cook-Moreau, Jean-Louis Beneytout, Bertrand Liagre. Cyclopamine and jervine induce COX-2 overexpression in human erythroleukemia cells but only cyclopamine has a pro-apoptotic effect. Experimental cell research. 2013 Apr; 319(7):1043-53. doi: 10.1016/j.yexcr.2013.01.014. [PMID: 23357584]
  • Jana Balbuena, Gisela Pachon, Guillermo Lopez-Torrents, Josep M Aran, Javier S Castresana, Jordi Petriz. ABCG2 is required to control the sonic hedgehog pathway in side population cells with stem-like properties. Cytometry. Part A : the journal of the International Society for Analytical Cytology. 2011 Sep; 79(9):672-83. doi: 10.1002/cyto.a.21103. [PMID: 21774076]
  • Jian-Liang Zhou, Gui-Zhong Xin, Zi-Qi Shi, Mei-Ting Ren, Lian-Wen Qi, Hui-Jun Li, Ping Li. Characterization and identification of steroidal alkaloids in Fritillaria species using liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry. Journal of chromatography. A. 2010 Nov; 1217(45):7109-22. doi: 10.1016/j.chroma.2010.09.019. [PMID: 20926090]
  • L K Bechtel, D T Lawrence, D Haverstick, J S Powers, S A Wyatt, T Croley, C P Holstege. Ingestion of false hellebore plants can cross-react with a digoxin clinical chemistry assay. Clinical toxicology (Philadelphia, Pa.). 2010 Jun; 48(5):435-42. doi: 10.3109/15563651003733666. [PMID: 20586573]
  • Jian Tang, Hui-Liang Li, Yun-Heng Shen, Hui-Zi Jin, Shi-Kai Yan, Xiao-Hua Liu, Hua-Wu Zeng, Run-Hui Liu, Ye-Xiong Tan, Wei-Dong Zhang. Antitumor and antiplatelet activity of alkaloids from veratrum dahuricum. Phytotherapy research : PTR. 2010 Jun; 24(6):821-6. doi: 10.1002/ptr.3022. [PMID: 20013819]
  • T Grobosch, T Binscheck, F Martens, D Lampe. Accidental intoxication with Veratrum album. Journal of analytical toxicology. 2008 Nov; 32(9):768-73. doi: 10.1093/jat/32.9.768. [PMID: 19021933]
  • Jian Tang, Hui-Liang Li, Yun-Heng Shen, Hui-Zi Jin, Shi-Kai Yan, Run-Hui Liu, Wei-Dong Zhang. Antitumor activity of extracts and compounds from the rhizomes of Veratrum dahuricum. Phytotherapy research : PTR. 2008 Aug; 22(8):1093-6. doi: 10.1002/ptr.2463. [PMID: 18570211]
  • Yue Cong, Jin-Hui Wang, Rui Wang, Yi-Mei Zeng, Chang-Da Liu, Xian Li. A study on the chemical constituents of Veratrum nigrum L. processed by rice vinegar. Journal of Asian natural products research. 2008 Jul; 10(7-8):619-24. doi: 10.1080/10286020802133266. [PMID: 18636372]
  • Sheng Zhang, Jianxia Zhou, Qingyao Shou, Ying Peng, Zhengwu Shen. [Determination of jervine and veratramine in Veratrum plants using high performance liquid chromatography coupled with evaporative light scattering detection]. Se pu = Chinese journal of chromatography. 2008 Jan; 26(1):56-9. doi: . [PMID: 18438025]
  • Kap-Rang Lee, Nobuyuki Kozukue, Jae-Sook Han, Joon-Hong Park, Eun-Young Chang, Eun-Jung Baek, Jong-Sun Chang, Mendel Friedman. Glycoalkaloids and metabolites inhibit the growth of human colon (HT29) and liver (HepG2) cancer cells. Journal of agricultural and food chemistry. 2004 May; 52(10):2832-9. doi: 10.1021/jf030526d. [PMID: 15137822]
  • Stephen T Lee, Kip E Panter, William Gaffield, Bryan L Stegelmeier. Development of an enzyme-linked immunosorbent assay for the veratrum plant teratogens: cyclopamine and jervine. Journal of agricultural and food chemistry. 2003 Jan; 51(3):582-6. doi: 10.1021/jf020961s. [PMID: 12537426]
  • R K Mann, P A Beachy. Cholesterol modification of proteins. Biochimica et biophysica acta. 2000 Dec; 1529(1-3):188-202. doi: 10.1016/s1388-1981(00)00148-7. [PMID: 11111088]
  • T Fukushima. [Monoamine oxidase (XXXVI). Characteristics of benzylamine oxidase in the dog serum]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 1975 Jul; 71(5):457-62. doi: . [PMID: 280]