Chlorprothixene (BioDeep_00000001934)

human metabolite blood metabolite Chemicals and Drugs

代谢物信息卡片

[3-(2-chloro-9H-thioxanthen-9-ylidene)propyl]dimethylamine

化学式: C18H18ClNS (315.08484180000005)
中文名称: 氯普噻吨
谱图信息: 最多检出来源 Homo sapiens(blood) 16.67%

分子结构信息

SMILES: CN(C)CC/C=C1C2=C(SC3=C\1C=CC=C3)C=CC(Cl)=C2
InChI: InChI=1S/C18H18ClNS/c1-20(2)11-5-7-14-15-6-3-4-8-17(15)21-18-10-9-13(19)12-16(14)18/h3-4,6-10,12H,5,11H2,1-2H3

描述信息

Chlorprothixene is only found in individuals that have used or taken this drug. It is a typical antipsychotic drug of the thioxanthene (tricyclic) class. Chlorprothixene exerts strong blocking effects by blocking the 5-HT2 D1, D2, D3, histamine H1, muscarinic and alpha1 adrenergic receptors. Chlorprothixene blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis.
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
N - Nervous system > N05 - Psycholeptics > N05A - Antipsychotics > N05AF - Thioxanthene derivatives
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018492 - Dopamine Antagonists
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
C78272 - Agent Affecting Nervous System > C29710 - Antipsychotic Agent
Chlorprothixene is a dopamine and histamine receptors antagonist with Kis of 18 nM, 2.96 nM, 4.56 nM, 9 nM and 3.75 nM for hD1, hD2, hD3, hD5 and hH1 receptors, respectively. Antipsychotic activity[1].

同义名列表

15 个代谢物同义名

[3-(2-chloro-9H-thioxanthen-9-ylidene)propyl]dimethylamine; Alpha-Chlorprothixene; cis-Chlorprothixene; Α-chlorprothixene; a-Chlorprothixene; Chloroprothixene; Chlorprothixenum; Chlorprothixine; chlorprothixene; Chlorprotixene; Chlorprotixine; Chlorprothixen; Chlorprotixen; Clorprotixeno; Chlothixen

数据库引用编号

18 个数据库交叉引用编号

ChEBI: CHEBI:50931
ChEBI: CHEBI:3651
KEGG: C07953
KEGGdrug: D00790
PubChem: 667467
PubChem: 2729
HMDB: HMDB0015369
Metlin: METLIN44107
DrugBank: DB01239
ChEMBL: CHEMBL908
Wikipedia: Chlorprothixene
MeSH: Chlorprothixene
chemspider: 580848
CAS: 113-59-7
PMhub: MS000001472
PubChem: 10154
NIKKAJI: J52.995H
medchemexpress: HY-B0274

分类词条

Thioxanthenes

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

9606 - Homo sapiens: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Bozhi Yuan, Mei Yuan. Changes of Mental State and Serum Prolactin Levels in Patients with Schizophrenia and Depression after Receiving the Combination Therapy of Amisulpride and Chloroprothixol Tablets. Computational and mathematical methods in medicine. 2022; 2022(?):6580030. doi: 10.1155/2022/6580030. [PMID: 35242209]
Xiao Yu, Xinlin Li, Sunzhao You, Yuhang Shi, Ruiqin Zhu, Ying Dong, Chuixiu Huang. Electromembrane extraction of chlorprothixene, haloperidol and risperidone from whole blood and urine. Journal of chromatography. A. 2020 Oct; 1629(?):461480. doi: 10.1016/j.chroma.2020.461480. [PMID: 32827905]
Jun-Ichi Kurita, Yuuka Hirao, Hirofumi Nakano, Yoshifumi Fukunishi, Yoshifumi Nishimura. Sertraline, chlorprothixene, and chlorpromazine characteristically interact with the REST-binding site of the corepressor mSin3, showing medulloblastoma cell growth inhibitory activities. Scientific reports. 2018 09; 8(1):13763. doi: 10.1038/s41598-018-31852-1. [PMID: 30213984]
Louise Skov, Sys Stybe Johansen, Kristian Linnet. Postmortem femoral blood reference concentrations of aripiprazole, chlorprothixene, and quetiapine. Journal of analytical toxicology. 2015 Jan; 39(1):41-4. doi: 10.1093/jat/bku121. [PMID: 25342720]
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