Epothilone A (BioDeep_00001883169)

Main id: BioDeep_00000009130

 

Chemicals and Drugs natural product


代谢物信息卡片


Epothilone A

化学式: C26H39NO6S (493.2498)
中文名称: 埃博霉素A
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C/C(=C\c1csc(C)n1)[C@@H]1C[C@@H]2O[C@@H]2CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1
InChI: InChI=1S/C26H39NO6S/c1-14-8-7-9-19-21(32-19)11-20(15(2)10-18-13-34-17(4)27-18)33-23(29)12-22(28)26(5,6)25(31)16(3)24(14)30/h10,13-14,16,19-22,24,28,30H,7-9,11-12H2,1-6H3/b15-10+/t14-,16+,19+,20-,21-,22-,24-/m0/s1

描述信息

An epithilone that is epothilone C in which the double bond in the macrocyclic lactone ring has been oxidised to the corresponding epoxide (the 13R,14S diastereoisomer).
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C273 - Antimitotic Agent
D050258 - Mitosis Modulators > D050256 - Antimitotic Agents > D050257 - Tubulin Modulators
D000970 - Antineoplastic Agents > D050256 - Antimitotic Agents
Epothilone A is a competitive inhibitor of the binding of [3H] paclitaxel to tubulin polymers, with a Ki of 0.6-1.4 μM.

同义名列表

3 个代谢物同义名

Epothilone A; Epo A; Epothilone A



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

10 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 16 ABCB1, ANG, ANXA5, BCL2, CASP3, CASP7, EGFR, ERBB2, FNTA, GLI1, MTOR, PGP, TUBB, TUBB3, TUBB4B, VEGFA
Peripheral membrane protein 3 ANXA5, CYP1B1, MTOR
Endosome membrane 2 EGFR, ERBB2
Endoplasmic reticulum membrane 4 BCL2, CYP1B1, EGFR, MTOR
Nucleus 14 ANG, BCL2, CASP3, CASP7, EGFR, ERBB2, GLI1, KLK3, MTOR, PARP1, TUBB, TUBB3, TUBB4B, VEGFA
cytosol 12 ANG, ANXA5, BCL2, CASP3, CASP7, ERBB2, FNTA, GLI1, MTOR, PARP1, TUBB, TUBB4B
dendrite 2 MTOR, TUBB3
nuclear body 1 PARP1
phagocytic vesicle 1 MTOR
nucleoplasm 6 CASP3, CASP7, ERBB2, GLI1, MTOR, PARP1
Cell membrane 3 ABCB1, EGFR, ERBB2
Cytoplasmic side 1 MTOR
lamellipodium 1 TUBB3
ruffle membrane 2 EGFR, ERBB2
Cell projection, growth cone 1 TUBB3
Early endosome membrane 1 EGFR
Multi-pass membrane protein 1 ABCB1
Golgi apparatus membrane 1 MTOR
cell junction 1 EGFR
cell surface 4 ABCB1, EGFR, EPO, VEGFA
glutamatergic synapse 2 CASP3, EGFR
Golgi apparatus 1 VEGFA
Golgi membrane 2 EGFR, MTOR
growth cone 2 ANG, TUBB3
lysosomal membrane 1 MTOR
neuromuscular junction 1 ERBB2
neuronal cell body 3 ANG, CASP3, TUBB3
presynaptic membrane 1 ERBB2
sarcolemma 1 ANXA5
Cytoplasm, cytosol 2 CASP7, PARP1
Lysosome 1 MTOR
endosome 1 EGFR
plasma membrane 5 ABCB1, EGFR, ERBB2, FNTA, KLK3
Membrane 9 ABCB1, ANXA5, BCL2, CYP1B1, EGFR, ERBB2, MTOR, PARP1, VEGFA
apical plasma membrane 3 ABCB1, EGFR, ERBB2
axon 1 TUBB3
basolateral plasma membrane 2 EGFR, ERBB2
extracellular exosome 7 ABCB1, ANXA5, EPO, KLK3, TUBB, TUBB3, TUBB4B
Lysosome membrane 1 MTOR
endoplasmic reticulum 2 BCL2, VEGFA
extracellular space 6 ANG, CASP7, EGFR, EPO, KLK3, VEGFA
perinuclear region of cytoplasm 2 EGFR, ERBB2
adherens junction 1 VEGFA
mitochondrion 3 BCL2, CYP1B1, PARP1
protein-containing complex 5 BCL2, EGFR, KLK3, PARP1, TUBB
intracellular membrane-bounded organelle 1 CYP1B1
Microsome membrane 2 CYP1B1, MTOR
filopodium 1 TUBB3
postsynaptic density 1 CASP3
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 2 EGFR, ERBB2
Secreted 3 ANG, EPO, VEGFA
extracellular region 8 ANG, ANXA5, EPO, ERBB2, KLK3, TUBB, TUBB4B, VEGFA
Mitochondrion outer membrane 2 BCL2, MTOR
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, MTOR
transcription regulator complex 1 PARP1
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 2 BCL2, EGFR
external side of plasma membrane 1 ANXA5
Extracellular vesicle 1 TUBB4B
Secreted, extracellular space, extracellular matrix 1 VEGFA
actin cytoskeleton 1 ANG
cytoplasmic vesicle 1 ERBB2
microtubule cytoskeleton 3 TUBB, TUBB3, TUBB4B
nucleolus 2 ANG, PARP1
Early endosome 1 ERBB2
Apical cell membrane 1 ABCB1
Cell projection, lamellipodium 1 TUBB3
Cell projection, ruffle membrane 1 ERBB2
Cytoplasm, perinuclear region 1 ERBB2
Membrane raft 2 EGFR, TUBB
pore complex 1 BCL2
Cytoplasm, cytoskeleton 3 TUBB, TUBB3, TUBB4B
focal adhesion 2 ANXA5, EGFR
microtubule 3 TUBB, TUBB3, TUBB4B
spindle 1 TUBB3
extracellular matrix 1 VEGFA
basement membrane 1 ANG
intracellular vesicle 1 EGFR
Nucleus, PML body 1 MTOR
PML body 1 MTOR
collagen-containing extracellular matrix 1 ANXA5
secretory granule 2 KLK3, VEGFA
axoneme 1 GLI1
ciliary tip 1 GLI1
Cell projection, filopodium 1 TUBB3
receptor complex 2 EGFR, ERBB2
Zymogen granule membrane 1 ANXA5
ciliary base 1 GLI1
chromatin 1 PARP1
microtubule associated complex 1 FNTA
cell periphery 1 TUBB3
mitotic spindle 3 TUBB, TUBB3, TUBB4B
Chromosome 2 ANG, PARP1
cytoskeleton 2 TUBB, TUBB4B
cytoplasmic ribonucleoprotein granule 1 TUBB
Secreted, extracellular space 1 CASP7
Nucleus, nucleolus 2 ANG, PARP1
nuclear replication fork 1 PARP1
chromosome, telomeric region 1 PARP1
site of double-strand break 1 PARP1
intercellular bridge 3 TUBB, TUBB3, TUBB4B
Cytoplasm, cytoskeleton, flagellum axoneme 1 TUBB4B
sperm flagellum 1 TUBB4B
nuclear envelope 2 MTOR, PARP1
Endomembrane system 1 MTOR
axonemal microtubule 1 TUBB4B
Cytoplasm, Stress granule 1 ANG
cytoplasmic stress granule 1 ANG
cell body 2 EPO, TUBB
myelin sheath 2 BCL2, ERBB2
basal plasma membrane 2 EGFR, ERBB2
synaptic membrane 1 EGFR
secretory granule lumen 1 EPO
platelet alpha granule lumen 1 VEGFA
endocytic vesicle 1 ANG
azurophil granule lumen 2 TUBB, TUBB4B
nuclear envelope lumen 1 TUBB
semaphorin receptor complex 1 ERBB2
[Isoform 2]: Cytoplasm 1 GLI1
vesicle membrane 1 ANXA5
clathrin-coated endocytic vesicle membrane 1 EGFR
protein-DNA complex 1 PARP1
external side of apical plasma membrane 1 ABCB1
death-inducing signaling complex 1 CASP3
[Isoform 1]: Cell membrane 1 ERBB2
Cytoplasmic vesicle, phagosome 1 MTOR
site of DNA damage 1 PARP1
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
angiogenin-PRI complex 1 ANG
ERBB3:ERBB2 complex 1 ERBB2
GLI-SUFU complex 1 GLI1
endothelial microparticle 1 ANXA5
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm 1 PARP1
BAD-BCL-2 complex 1 BCL2
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
CAAX-protein geranylgeranyltransferase complex 1 FNTA
protein farnesyltransferase complex 1 FNTA


文献列表

  • Junheng Liang, Huimin Wang, Xiaoying Bian, Youming Zhang, Guoping Zhao, Xiaoming Ding. Heterologous redox partners supporting the efficient catalysis of epothilone B biosynthesis by EpoK in Schlegelella brevitalea. Microbial cell factories. 2020 Sep; 19(1):180. doi: 10.1186/s12934-020-01439-5. [PMID: 32933531]
  • T F Taraschi, D Trelka, T Schneider, I Matthews. Plasmodium falciparum: characterization of organelle migration during merozoite morphogenesis in asexual malaria infections. Experimental parasitology. 1998 Mar; 88(3):184-93. doi: 10.1006/expr.1998.4254. [PMID: 9562421]
  • R J Kowalski, P Giannakakou, E Hamel. Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxol(R)). The Journal of biological chemistry. 1997 Jan; 272(4):2534-41. doi: 10.1074/jbc.272.4.2534. [PMID: 8999970]