phosalone (BioDeep_00001873563)

   

Industrial Pollutants natural product


代谢物信息卡片


phosalone

化学式: C12H15ClNO4PS2 (366.9869)
中文名称: 甲醇中伏杀硫磷溶液, 磷胺
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCOP(=S)(OCC)SCn1c(=O)oc2cc(Cl)ccc21
InChI: InChI=1S/C12H15ClNO4PS2/c1-3-16-19(20,17-4-2)21-8-14-10-6-5-9(13)7-11(10)18-12(14)15/h5-7H,3-4,8H2,1-2H3

描述信息

D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D002800 - Cholinesterase Inhibitors
D010575 - Pesticides > D007306 - Insecticides
D004791 - Enzyme Inhibitors
D016573 - Agrochemicals

同义名列表

3 个代谢物同义名

phosalone; PSL; Phosalone



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

6 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 AIMP2, CAT, CCND1, HPGDS, SLC5A5, TP53
Peripheral membrane protein 1 ACHE
Nucleus 6 ACHE, AIMP2, CCND1, PPARA, SLC5A5, TP53
cytosol 9 AIMP2, APOA4, CAT, CCND1, CD44, GPT, GSR, HPGDS, TP53
dendrite 1 THY1
centrosome 2 CCND1, TP53
nucleoplasm 5 ATP2B1, CCND1, HPGDS, PPARA, TP53
Cell membrane 6 ACHE, ATP2B1, CD44, SLC5A5, THY1, TNF
Multi-pass membrane protein 2 ATP2B1, SLC5A5
Synapse 4 ACHE, APOA4, ATP2B1, SLITRK1
cell surface 5 ACHE, CD44, EPO, THY1, TNF
glutamatergic synapse 3 ATP2B1, SLITRK1, THY1
Golgi apparatus 2 ACHE, CD44
growth cone 1 THY1
neuromuscular junction 1 ACHE
neuronal cell body 1 TNF
postsynapse 1 THY1
presynaptic membrane 1 ATP2B1
Cytoplasm, cytosol 1 AIMP2
Presynapse 1 THY1
plasma membrane 8 ACHE, ATP2B1, BCHE, CD44, SLC5A5, SLITRK1, THY1, TNF
synaptic vesicle membrane 1 ATP2B1
Membrane 8 ACHE, AIMP2, ATP2B1, CAT, CD44, SLC5A5, SLITRK1, TP53
apical plasma membrane 2 CD44, THY1
basolateral plasma membrane 2 ATP2B1, CD44
extracellular exosome 10 APOA4, ATP2B1, CAT, CD44, EPO, GPT, GSR, SLC5A5, THY1, TTR
endoplasmic reticulum 2 THY1, TP53
extracellular space 7 ACHE, APOA4, BCHE, EPO, TG, TNF, TTR
perinuclear region of cytoplasm 1 ACHE
bicellular tight junction 1 CCND1
mitochondrion 3 CAT, GSR, TP53
protein-containing complex 2 CAT, TP53
intracellular membrane-bounded organelle 3 ATP2B1, CAT, HPGDS
Single-pass type I membrane protein 2 CD44, SLITRK1
Secreted 8 ACHE, APOA4, BCHE, CD44, EPO, SLITRK1, TG, TTR
extracellular region 11 ACHE, APOA4, BCHE, CAT, CD44, EPO, SLITRK1, TG, THY1, TNF, TTR
Single-pass membrane protein 1 CD44
neuronal cell body membrane 1 THY1
Mitochondrion matrix 1 TP53
mitochondrial matrix 3 CAT, GSR, TP53
Extracellular side 1 ACHE
transcription regulator complex 1 TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
Nucleus membrane 1 CCND1
nuclear membrane 1 CCND1
external side of plasma membrane 3 GSR, THY1, TNF
Extracellular vesicle 2 APOA4, SLC5A5
chylomicron 1 APOA4
high-density lipoprotein particle 1 APOA4
low-density lipoprotein particle 1 APOA4
very-low-density lipoprotein particle 1 APOA4
nucleolus 1 TP53
Early endosome 1 APOA4
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Membrane raft 2 THY1, TNF
Cytoplasm, cytoskeleton 1 TP53
focal adhesion 3 CAT, CD44, THY1
axolemma 1 THY1
GABA-ergic synapse 1 SLITRK1
Peroxisome 1 CAT
basement membrane 1 ACHE
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
Nucleus, PML body 1 TP53
PML body 1 TP53
collagen-containing extracellular matrix 1 APOA4
lateral plasma membrane 1 ATP2B1
chromatin 2 PPARA, TP53
cell projection 2 ATP2B1, CD44
phagocytic cup 1 TNF
blood microparticle 2 APOA4, BCHE
Basolateral cell membrane 1 ATP2B1
Lipid-anchor, GPI-anchor 2 ACHE, THY1
site of double-strand break 1 TP53
microvillus 1 CD44
Cell projection, microvillus 1 CD44
Presynaptic cell membrane 1 ATP2B1
cell body 1 EPO
side of membrane 2 ACHE, THY1
germ cell nucleus 1 TP53
replication fork 1 TP53
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 2 CAT, EPO
secretory granule membrane 1 CD44
endoplasmic reticulum lumen 2 APOA4, BCHE
nuclear matrix 1 TP53
transcription repressor complex 2 CCND1, TP53
azurophil granule lumen 1 TTR
postsynaptic density membrane 1 SLITRK1
immunological synapse 1 ATP2B1
nuclear envelope lumen 1 BCHE
[Isoform 1]: Nucleus 1 TP53
synaptic cleft 1 ACHE
aminoacyl-tRNA synthetase multienzyme complex 1 AIMP2
dendrite membrane 1 THY1
cyclin-dependent protein kinase holoenzyme complex 1 CCND1
lamellipodium membrane 1 CD44
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
catalase complex 1 CAT
macrophage migration inhibitory factor receptor complex 1 CD44
photoreceptor ribbon synapse 1 ATP2B1
cyclin D1-CDK4 complex 1 CCND1
[Isoform H]: Cell membrane 1 ACHE
cyclin D1-CDK6 complex 1 CCND1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Marjan Koushkestani, Samira Abbasi-Moayed, Forough Ghasemi, Vahideh Mahdavi, M Reza Hormozi-Nezhad. Simultaneous detection and identification of thiometon, phosalone, and prothioconazole pesticides using a nanoplasmonic sensor array. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2021 May; 151(?):112109. doi: 10.1016/j.fct.2021.112109. [PMID: 33716053]
  • Ehsan Parsaeyan, Moosa Saber, Seyed Ali Safavi, Nafiseh Poorjavad, Antonio Biondi. Side effects of chlorantraniliprole, phosalone and spinosad on the egg parasitoid, Trichogramma brassicae. Ecotoxicology (London, England). 2020 Sep; 29(7):1052-1061. doi: 10.1007/s10646-020-02235-y. [PMID: 32448953]
  • Seyedeh Farnaz Ghasemi-Niri, Faheem Maqbool, Maryam Baeeri, Mahdi Gholami, Mohammad Abdollahi. Phosalone-induced inflammation and oxidative stress in the colon: Evaluation and treatment. World journal of gastroenterology. 2016 Jun; 22(21):4999-5011. doi: 10.3748/wjg.v22.i21.4999. [PMID: 27275092]
  • M Malekmohammadi, H Galehdari. Target site insensitivity mutations in the AChE enzyme confer resistance to organophosphorous insecticides in Leptinotarsa decemlineata (Say). Pesticide biochemistry and physiology. 2016 Jan; 126(?):85-91. doi: 10.1016/j.pestbp.2015.08.002. [PMID: 26778439]
  • Ali Alizadeh, Khalil Talebi-Jahromi, Vahid Hosseininaveh, Mohammad Ghadamyari. Toxicological and biochemical characterizations of AChE in phosalone-susceptible and resistant populations of the common pistachio psyllid, Agonoscena pistaciae. Journal of insect science (Online). 2014 Feb; 14(?):18. doi: 10.1093/jis/14.1.18. [PMID: 25373165]
  • Hasan Kaya, Ekrem Şanver Çelik, Mert Gürkan, Sevdan Yılmaz, Mehmet Akbulut. Effects of subchronic exposure to phosalone on oxidative stress and histopathological alterations in common carp (Cyprinus carpio, L., 1758). Journal of toxicology and environmental health. Part A. 2013; 76(14):853-64. doi: 10.1080/15287394.2013.823136. [PMID: 24053362]
  • Hiroyuki Kojima, Fumihiro Sata, Shinji Takeuchi, Tatsuya Sueyoshi, Tadanori Nagai. Comparative study of human and mouse pregnane X receptor agonistic activity in 200 pesticides using in vitro reporter gene assays. Toxicology. 2011 Feb; 280(3):77-87. doi: 10.1016/j.tox.2010.11.008. [PMID: 21115097]
  • Abdul Rashid Bhat, Muhammed Afzal Wani, A R Kirmani, T H Raina. Pesticides and brain cancer linked in orchard farmers of Kashmir. Indian journal of medical and paediatric oncology : official journal of Indian Society of Medical & Paediatric Oncology. 2010 Oct; 31(4):110-20. doi: 10.4103/0971-5851.76191. [PMID: 21584215]
  • Abdul Rashid Bhat, Muhammed Afzal Wani, A R Kirmani. Brain cancer and pesticide relationship in orchard farmers of Kashmir. Indian journal of occupational and environmental medicine. 2010 Sep; 14(3):78-86. doi: 10.4103/0019-5278.75694. [PMID: 21461159]
  • Pedro Henrique Viana de Carvalho, Vanessa de Menezes Prata, Péricles Barreto Alves, Sandro Navickiene. Determination of six pesticides in the medicinal herb Cordia salicifolia by matrix solid-phase dispersion and gas chromatography/mass spectrometry. Journal of AOAC International. 2009 Jul; 92(4):1184-9. doi: . [PMID: 19714988]
  • Pedro Henrique Viana de Carvalho, Alysson Santos Barreto, Marcelo O Rodrigues, Vanessa de Menezes Prata, Péricles Barreto Alves, Maria Eliane de Mesquita, Severino Alves, Sandro Navickiene. Two-dimensional coordination polymer matrix for solid-phase extraction of pesticide residues from plant Cordia salicifolia. Journal of separation science. 2009 Jun; 32(12):2132-8. doi: 10.1002/jssc.200900076. [PMID: 19479754]
  • Mathieu Valcke, Michèle Bouchard. Determination of no-observed effect level (NOEL)-biomarker equivalents to interpret biomonitoring data for organophosphorus pesticides in children. Environmental health : a global access science source. 2009 Feb; 8(?):5. doi: 10.1186/1476-069x-8-5. [PMID: 19228383]
  • R Karimzadeh, M J Hejazi, F Rahimzadeh Khoei, M Moghaddam. Laboratory evaluation of five chitin synthesis inhibitors against the colorado potato beetle, Leptinotarsa decemlineata. Journal of insect science (Online). 2007; 7(?):1-6. doi: 10.1673/031.007.5001. [PMID: 20345285]
  • A Alizadeh, M A Samih, H Izadi. Compatibility of Verticillium lecani (Zimm.) with several pesticides. Communications in agricultural and applied biological sciences. 2007; 72(4):1011-5. doi: ". [PMID: 18396843]
  • M Mohammadi Sharif, M J Hejazi, A Mohammadi, M R Rashidi. Resistance status of the Colorado potato beetle, Leptinotarsa decemlineata, to endosulfan in East Azarbaijan and Ardabil provinces of Iran. Journal of insect science (Online). 2007; 7(?):1-7. doi: 10.1673/031.007.3101. [PMID: 20298109]
  • Jacqueline Idinger, Tamara Coja, Sylvia Blümel. Effects of the benzoxazoid DIMBOA, selected degradation products, and structure-related pesticides on soil organisms. Ecotoxicology and environmental safety. 2006 Sep; 65(1):1-13. doi: 10.1016/j.ecoenv.2005.03.006. [PMID: 16406583]
  • Tamara Coja, Jacqueline Idinger, Sylvia Blümel. Effects of the benzoxazolinone BOA, selected degradation products and structure related pesticides on soil organisms. Ecotoxicology (London, England). 2006 Feb; 15(1):61-72. doi: 10.1007/s10646-005-0042-4. [PMID: 16344919]
  • Khalil Talebi. Dissipation of phosalone and diazinon in fresh and dried alfalfa. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. 2006; 41(5):595-603. doi: 10.1080/03601230600701759. [PMID: 16785169]
  • K J Min, C G Cha, W Popendorf. Determination of urinary metabolites of phosalone, methidathion, and IBP after oral administration and dermal application to rats. Bulletin of environmental contamination and toxicology. 2005 May; 74(5):809-16. doi: 10.1007/s00128-005-0653-8. [PMID: 16097311]
  • L Raudonis, E Surviliene, A Valiuskaite. Toxicity of pesticides to predatory mites and insects in apple-tree site under field conditions. Environmental toxicology. 2004 Aug; 19(4):291-5. doi: 10.1002/tox.20036. [PMID: 15269898]
  • I Altuntas, N Delibas, D K Doguc, S Ozmen, F Gultekin. Role of reactive oxygen species in organophosphate insecticide phosalone toxicity in erythrocytes in vitro. Toxicology in vitro : an international journal published in association with BIBRA. 2003 Apr; 17(2):153-7. doi: 10.1016/s0887-2333(02)00133-9. [PMID: 12650668]
  • Bozena Morzycka. Simple method for the determination of trace levels of pesticides in honeybees using matrix solid-phase dispersion and gas chromatography. Journal of chromatography. A. 2002 Dec; 982(2):267-73. doi: 10.1016/s0021-9673(02)01505-4. [PMID: 12489883]
  • V Issert, R Lazaro, F Lamaty, V Rolland, P Besançon, B Caporiccio, P Grenier, V Bellon-Maurel. Production of polyclonal antibodies towards the immunodetection of insecticide phosalone. Amino acids. 1999; 17(4):377-89. doi: 10.1007/bf01361663. [PMID: 10707767]
  • Z Vasilić, V Drevenkar, B Stengl, Z Fröbe, V Rumenjak. Diethylphosphorus metabolites in serum and urine of persons poisoned by phosalone. Chemico-biological interactions. 1993 Jun; 87(1-3):305-13. doi: 10.1016/0009-2797(93)90058-7. [PMID: 8343988]
  • S J Reddy, B V Reddy, R Ramamurthi. Effect of chronic insecticide, phosalone, toxicity on haem synthesis and blood gas composition in the rat. Biochemistry international. 1992 Mar; 26(3):551-8. doi: NULL. [PMID: 1627165]
  • P N Kolbasin. [Characteristics of modification of lipids of erythrocyte membranes and blood plasma in combined action of pesticides after physical exercise of varied intensity]. Gigiena truda i professional'nye zabolevaniia. 1992; ?(6):43-4. doi: NULL. [PMID: 1282489]
  • S J Reddy, B V Reddy, R Ramamurthi. Impact of chronic phosalone toxicity on erythropoietic activity of fish, Oreochromis mossambicus. Biochemistry international. 1991 Oct; 25(3):547-52. doi: . [PMID: 1805799]
  • M A O'Malley, S A McCurdy. Subacute poisoning with phosalone, an organophosphate insecticide. The Western journal of medicine. 1990 Dec; 153(6):619-24. doi: . [PMID: 2293466]
  • S J Reddy, D C Reddy, V Kalarani, R Ramamurthi. Chronic toxicity of phosalone to rats: effect on erythropoiesis. Bulletin of environmental contamination and toxicology. 1989 Dec; 43(6):893-8. doi: 10.1007/bf01702061. [PMID: 2597794]
  • V Drevenkar, B Stengl, B Tkalcević, Z Vasilić. Occupational exposure control by simultaneous determination of N-methylcarbamates and organophosphorus pesticide residues in human urine. International journal of environmental analytical chemistry. 1983; 14(3):215-30. doi: 10.1080/03067318308071621. [PMID: 6853013]
  • S Saigal, V K Bhatnagar, A N Malviya. Effect of selected pesticides on alkaline and acid phosphatase in the rat. Toxicology letters. 1982 Jul; 12(2-3):177-80. doi: 10.1016/0378-4274(82)90182-5. [PMID: 7112611]
  • V Drevenkar, Z Fröbe, Z Vasilić, B Tkalcević, Z Stefanac. The rate of urinary excretion of phosalone residues in occupationally exposed persons. The Science of the total environment. 1979 Dec; 13(3):235-43. doi: 10.1016/0048-9697(79)90104-9. [PMID: 538451]
  • Z Mikhaĭlova, R Vachkova-Petrova. [Embryotropic action of phosalone]. Problemi na khigienata. 1976; 2(?):209-14. doi: . [PMID: 1032714]
  • A C Buck. Disorders of micturition in bacterial prostatitis. Proceedings of the Royal Society of Medicine. 1975 Aug; 68(8):508-11. doi: NULL. [PMID: 681]