Lariam (BioDeep_00001871311)
代谢物信息卡片
mefloquine
化学式: C17H16F6N2O (378.1167)
中文名称: 氟甲喹羟哌啶
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CCNC(C1)C(C2=CC(=NC3=C2C=CC=C3C(F)(F)F)C(F)(F)F)O
InChI: InChI=1S/C17H16F6N2O/c18-16(19,20)11-5-3-4-9-10(15(26)12-6-1-2-7-24-12)8-13(17(21,22)23)25-14(9)11/h3-5,8,12,15,24,26H,1-2,6-7H2
描述信息
P - Antiparasitic products, insecticides and repellents > P01 - Antiprotozoals > P01B - Antimalarials > P01BC - Methanolquinolines
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
3 个代谢物同义名
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:63681
- PubChem: 4046
- DrugBank: DB00358
- ChEMBL: CHEMBL416956
- MeSH: Mefloquine
- CAS: 53230-10-7
- CAS: 49752-90-1
- KEGG: C07633
- PubChem: 9835
- KNApSAcK: 63609
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Qian Tao, Nian Liu, Jie Wu, Jing Chen, Xiang Chen, Cong Peng. Mefloquine enhances the efficacy of anti-PD-1 immunotherapy via IFN-γ-STAT1-IRF1-LPCAT3-induced ferroptosis in tumors.
Journal for immunotherapy of cancer.
2024 Mar; 12(3):. doi:
10.1136/jitc-2023-008554. [PMID: 38471712] - Xiang Wang, Jinxiu Chen, Jing Gong, Ying Wu, Xiang-Hao Liu. JC virus-induced progressive multifocal leukoencephalopathy in a presumably healthy patient.
BMC neurology.
2022 Dec; 22(1):462. doi:
10.1186/s12883-022-03004-6. [PMID: 36494784] - Carolina Q Sacramento, Natalia Fintelman-Rodrigues, Suelen S G Dias, Jairo R Temerozo, Aline de Paula D Da Silva, Carine S da Silva, Camilla Blanco, André C Ferreira, Mayara Mattos, Vinicius C Soares, Filipe Pereira-Dutra, Milene Dias Miranda, Debora F Barreto-Vieira, Marcos Alexandre N da Silva, Suzana S Santos, Mateo Torres, Otávio Augusto Chaves, Rajith K R Rajoli, Alberto Paccanaro, Andrew Owen, Dumith Chequer Bou-Habib, Patrícia T Bozza, Thiago Moreno L Souza. Unlike Chloroquine, Mefloquine Inhibits SARS-CoV-2 Infection in Physiologically Relevant Cells.
Viruses.
2022 02; 14(2):. doi:
10.3390/v14020374. [PMID: 35215969] - John O Olanlokun, Wisdom Oshireku Abiodun, Oluwakemi Ebenezer, Neil A Koorbanally, Olufunso Olabode Olorunsogo. Curcumin modulates multiple cell death, matrix metalloproteinase activation and cardiac protein release in susceptible and resistant Plasmodium berghei-infected mice.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Feb; 146(?):112454. doi:
10.1016/j.biopha.2021.112454. [PMID: 34894518] - Bing Wan, Zhenghong Wu, Xiulan Zhang, Birun Huang. Mefloquine as a dual inhibitor of glioblastoma angiogenesis and glioblastoma via disrupting lysosomal function.
Biochemical and biophysical research communications.
2021 11; 580(?):7-13. doi:
10.1016/j.bbrc.2021.09.069. [PMID: 34607260] - Wegdan M Abd El Wahab, Ayman A El-Badry, Soheir S Mahmoud, Yaser A El-Badry, Mohamed A El-Badry, Doaa A Hamdy. Ginger (Zingiber Officinale)-derived nanoparticles in Schistosoma mansoni infected mice: Hepatoprotective and enhancer of etiological treatment.
PLoS neglected tropical diseases.
2021 05; 15(5):e0009423. doi:
10.1371/journal.pntd.0009423. [PMID: 34014936] - Marinalva Cardoso Dos Santos, João Luís Rheingantz Scaini, Márcio Vinicius Costa Lopes, Beatriz Gonçalves Rodrigues, Nichole Osti Silva, Carla Roberta Lopes Borges, Sandra Cruz Dos Santos, Karina Dos Santos Machado, Adriano Velasque Werhli, Pedro Eduardo Almeida da Silva, Maria C S Lourenço, Emerson T da Silva, Marcus V N de Souza, Vânia Rodrigues de Lima, Raoni Schroeder B Gonçalves. Mefloquine synergism with anti-tuberculosis drugs and correlation to membrane effects: Biologic, spectroscopic and molecular dynamics simulations studies.
Bioorganic chemistry.
2021 05; 110(?):104786. doi:
10.1016/j.bioorg.2021.104786. [PMID: 33740676] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Airton C Martins, Monica M B Paoliello, Anca O Docea, Abel Santamaria, Alexey A Tinkov, Anatoly V Skalny, Michael Aschner. Review of the mechanism underlying mefloquine-induced neurotoxicity.
Critical reviews in toxicology.
2021 03; 51(3):209-216. doi:
10.1080/10408444.2021.1901258. [PMID: 33905310] - Bernhard Ellinger, Denisa Bojkova, Andrea Zaliani, Jindrich Cinatl, Carsten Claussen, Sandra Westhaus, Oliver Keminer, Jeanette Reinshagen, Maria Kuzikov, Markus Wolf, Gerd Geisslinger, Philip Gribbon, Sandra Ciesek. A SARS-CoV-2 cytopathicity dataset generated by high-content screening of a large drug repurposing collection.
Scientific data.
2021 02; 8(1):70. doi:
10.1038/s41597-021-00848-4. [PMID: 33637768] - Mathieu Gendrot, Isabelle Duflot, Manon Boxberger, Océane Delandre, Priscilla Jardot, Marion Le Bideau, Julien Andreani, Isabelle Fonta, Joel Mosnier, Clara Rolland, Sébastien Hutter, Bernard La Scola, Bruno Pradines. Antimalarial artemisinin-based combination therapies (ACT) and COVID-19 in Africa: In vitro inhibition of SARS-CoV-2 replication by mefloquine-artesunate.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.
2020 Oct; 99(?):437-440. doi:
10.1016/j.ijid.2020.08.032. [PMID: 32805422] - Britta Lundström-Stadelmann, Reto Rufener, Andrew Hemphill. Drug repurposing applied: Activity of the anti-malarial mefloquine against Echinococcus multilocularis.
International journal for parasitology. Drugs and drug resistance.
2020 08; 13(?):121-129. doi:
10.1016/j.ijpddr.2020.06.002. [PMID: 32636148] - Hua-Hao Fan, Li-Qin Wang, Wen-Li Liu, Xiao-Ping An, Zhen-Dong Liu, Xiao-Qi He, Li-Hua Song, Yi-Gang Tong. Repurposing of clinically approved drugs for treatment of coronavirus disease 2019 in a 2019-novel coronavirus-related coronavirus model.
Chinese medical journal.
2020 May; 133(9):1051-1056. doi:
10.1097/cm9.0000000000000797. [PMID: 32149769] - Abhishek Kumar, Debasish Kumar Ghosh, Akash Ranjan. Mefloquine binding to human acyl-CoA binding protein leads to redox stress-mediated apoptotic death of human neuroblastoma cells.
Neurotoxicology.
2020 03; 77(?):169-180. doi:
10.1016/j.neuro.2020.01.006. [PMID: 31987860] - José Luiz Fernandes Vieira, Juan Gonzalo Bardalez Rivera, Luann Wendel Pereira de Sena, Michelle Valeria Dias Ferreira. Association of Lipid Levels with Mefloquine and Carboxy-Mefloquine Concentrations in Patients with Uncomplicated Falciparum Malaria.
Antimicrobial agents and chemotherapy.
2020 02; 64(3):. doi:
10.1128/aac.01731-19. [PMID: 31844010] - Kabiru A Musa, Nor F W Ridzwan, Saharuddin B Mohamad, Saad Tayyab. Combination mode of antimalarial drug mefloquine and human serum albumin: Insights from spectroscopic and docking approaches.
Biopolymers.
2020 Feb; 111(2):e23337. doi:
10.1002/bip.23337. [PMID: 31691964] - Aaron M Izes, Benjamin Kimble, Jacqueline M Norris, Merran Govendir. Assay validation and determination of in vitro binding of mefloquine to plasma proteins from clinically normal and FIP-affected cats.
PloS one.
2020; 15(8):e0236754. doi:
10.1371/journal.pone.0236754. [PMID: 32756590] - Ryusei Nishigori, Yoko Warabi, Yukiko Shishido-Hara, Kazuo Nakamichi, Yasuhiro Nakata, Takashi Komori, Eiji Isozaki. Inflammatory Cerebellar PML with a CD4/CD8 Ratio of 2.9 Showed a Favorable Prognosis in a Patient with Rheumatoid Arthritis.
Internal medicine (Tokyo, Japan).
2019 Nov; 58(22):3323-3329. doi:
10.2169/internalmedicine.3038-19. [PMID: 31366796] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Abdel Jelil Njouendou, Chi Anizette Kien, Mathias E Esum, Manuel Ritter, Winston Patrick Chounna Ndongmo, Fanny Fri Fombad, Narcisse Victor T Gandjui, Flobert Njiokou, Peter Enyong, Kenneth Pfarr, Joseph Turner, Laura E Layland, Achim Hoerauf, Samuel Wanji. In vitro maintenance of Mansonella perstans microfilariae and its relevance for drug screening.
Experimental parasitology.
2019 Nov; 206(?):107769. doi:
10.1016/j.exppara.2019.107769. [PMID: 31580876] - Geoffrey Odhiambo, Elke Bergmann-Leitner, Moureen Maraka, Christine N L Wanjala, Elizabeth Duncan, John Waitumbi, Ben Andagalu, Walter G Z O Jura, Sheetij Dutta, Evelina Angov, Bernhards R Ogutu, Edwin Kamau, Daniel Ochiel. Correlation Between Malaria-Specific Antibody Profiles and Responses to Artemisinin Combination Therapy for Treatment of Uncomplicated Malaria in Western Kenya.
The Journal of infectious diseases.
2019 05; 219(12):1969-1979. doi:
10.1093/infdis/jiz027. [PMID: 30649381] - Abhishek Kumar, Debasish Kumar Ghosh, Jamshaid Ali, Akash Ranjan. Characterization of Lipid Binding Properties of Plasmodium falciparum Acyl-Coenzyme A Binding Proteins and Their Competitive Inhibition by Mefloquine.
ACS chemical biology.
2019 05; 14(5):901-915. doi:
10.1021/acschembio.9b00003. [PMID: 30986346] - Monia Guidi, Thomas Mercier, Manel Aouri, Laurent A Decosterd, Chantal Csajka, Bernhards Ogutu, Gwénaëlle Carn, Jean-René Kiechel. Population pharmacokinetics and pharmacodynamics of the artesunate-mefloquine fixed dose combination for the treatment of uncomplicated falciparum malaria in African children.
Malaria journal.
2019 Apr; 18(1):139. doi:
10.1186/s12936-019-2754-6. [PMID: 30999915] - Michael Ramharter, Matthias Schwab, Ghyslain Mombo-Ngoma, Rella Zoleko Manego, Daisy Akerey-Diop, Arti Basra, Jean-Rodolphe Mackanga, Heike Würbel, Jan-Georg Wojtyniak, Raquel Gonzalez, Ute Hofmann, Mirjam Geditz, Pierre-Blaise Matsiegui, Peter G Kremsner, Clara Menendez, Reinhold Kerb, Thorsten Lehr. Population Pharmacokinetics of Mefloquine Intermittent Preventive Treatment for Malaria in Pregnancy in Gabon.
Antimicrobial agents and chemotherapy.
2019 02; 63(2):. doi:
10.1128/aac.01113-18. [PMID: 30455233] - Trevor N Johnson, Yumi Cleary, Neil Parrott, Bruno Reigner, James R Smith, Stephen Toovey. Development of a physiologically based pharmacokinetic model for mefloquine and its application alongside a clinical effectiveness model to select an optimal dose for prevention of malaria in young Caucasian children.
British journal of clinical pharmacology.
2019 01; 85(1):100-113. doi:
10.1111/bcp.13764. [PMID: 30198595] - Sören Frahm, Anisuzzaman Anisuzzaman, Ulrich Fabien Prodjinotho, Nermina Vejzagić, Admar Verschoor, Clarissa Prazeres da Costa. A novel cell-free method to culture Schistosoma mansoni from cercariae to juvenile worm stages for in vitro drug testing.
PLoS neglected tropical diseases.
2019 01; 13(1):e0006590. doi:
10.1371/journal.pntd.0006590. [PMID: 30689639] - Richard E Haaland, Kephas Otieno, Amy Martin, Abraham Katana, Chuong Dinh, Laurence Slutsker, Clara Menendez, Raquel Gonzalez, John Williamson, Walid Heneine, Meghna Desai. Short Communication: Reduced Nevirapine Concentrations Among HIV-Positive Women Receiving Mefloquine for Intermittent Preventive Treatment for Malaria Control During Pregnancy.
AIDS research and human retroviruses.
2018 11; 34(11):912-915. doi:
10.1089/aid.2018.0042. [PMID: 30173559] - Nele Seemann, Andrea Welling, Ingo Rustenbeck. The inhibitor of connexin Cx36 channels, mefloquine, inhibits voltage-dependent Ca2+ channels and insulin secretion.
Molecular and cellular endocrinology.
2018 09; 472(?):97-106. doi:
10.1016/j.mce.2017.11.024. [PMID: 29208420] - Reto Rufener, Dominic Ritler, Jana Zielinski, Luca Dick, Emerson Teixeira da Silva, Adriele da Silva Araujo, Deborah Elisabeth Joekel, David Czock, Christine Goepfert, Adriana Marques Moraes, Marcus Vinicius Nora de Souza, Joachim Müller, Meike Mevissen, Andrew Hemphill, Britta Lundström-Stadelmann. Activity of mefloquine and mefloquine derivatives against Echinococcus multilocularis.
International journal for parasitology. Drugs and drug resistance.
2018 08; 8(2):331-340. doi:
10.1016/j.ijpddr.2018.06.004. [PMID: 29933218] - Sarah M Tindall, Cindy Vallières, Dev H Lakhani, Farida Islahudin, Kang-Nee Ting, Simon V Avery. Heterologous Expression of a Novel Drug Transporter from the Malaria Parasite Alters Resistance to Quinoline Antimalarials.
Scientific reports.
2018 02; 8(1):2464. doi:
10.1038/s41598-018-20816-0. [PMID: 29410428] - Arnold Donkor Forkuo, Charles Ansah, Kwesi Boadu Mensah, Kofi Annan, Ben Gyan, Anjo Theron, Dalu Mancama, Colin W Wright. In vitro anti-malarial interaction and gametocytocidal activity of cryptolepine.
Malaria journal.
2017 12; 16(1):496. doi:
10.1186/s12936-017-2142-z. [PMID: 29282057] - Wei-Lun Tang, Wei-Hsin Tang, Weihsu Claire Chen, Charles Diako, Carolyn F Ross, Shyh-Dar Li. Development of a Rapidly Dissolvable Oral Pediatric Formulation for Mefloquine Using Liposomes.
Molecular pharmaceutics.
2017 06; 14(6):1969-1979. doi:
10.1021/acs.molpharmaceut.7b00077. [PMID: 28460165] - James S McCarthy, Julie Lotharius, Thomas Rückle, Stephan Chalon, Margaret A Phillips, Suzanne Elliott, Silvana Sekuloski, Paul Griffin, Caroline L Ng, David A Fidock, Louise Marquart, Noelle S Williams, Nathalie Gobeau, Lidiya Bebrevska, Maria Rosario, Kennan Marsh, Jörg J Möhrle. Safety, tolerability, pharmacokinetics, and activity of the novel long-acting antimalarial DSM265: a two-part first-in-human phase 1a/1b randomised study.
The Lancet. Infectious diseases.
2017 06; 17(6):626-635. doi:
10.1016/s1473-3099(17)30171-8. [PMID: 28363636] - Eiichi Ohnuki, Shinya Asayama, Tomoko Asayama, Kazuo Nakamichi, Masayuki Saijo, Satoru Kosaka. A case of progressive multifocal leukoencephalopathy with chronic renal failure, whose JC virus in cerebrospinal fluid disappeared after mefloquine-mirtazapine dual therapy.
Rinsho shinkeigaku = Clinical neurology.
2016 10; 56(10):705-708. doi:
10.5692/clinicalneurol.cn-000928. [PMID: 27645758] - Andrea Hubeny, Markus Keiser, Stefan Oswald, Gabriele Jedlitschky, Heyo K Kroemer, Werner Siegmund, Markus Grube. Expression of Organic Anion Transporting Polypeptide 1A2 in Red Blood Cells and Its Potential Impact on Antimalarial Therapy.
Drug metabolism and disposition: the biological fate of chemicals.
2016 10; 44(10):1562-8. doi:
10.1124/dmd.116.069807. [PMID: 27504015] - José Luiz Fernandes Vieira, Larissa Maria Guimarães Borges, Michelle Valéria Dias Ferreira, Juan Gonzalo Bardarez Rivera, Margarete do Socorro Mendonça Gomes. Patient age does not affect mefloquine concentrations in erythrocytes and plasma during the acute phase of falciparum malaria.
The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases.
2016 Sep; 20(5):482-6. doi:
10.1016/j.bjid.2016.07.005. [PMID: 27542866] - Matthew J Grigg, Timothy William, Jayaram Menon, Bridget E Barber, Christopher S Wilkes, Giri S Rajahram, Michael D Edstein, Sarah Auburn, Ric N Price, Tsin W Yeo, Nicholas M Anstey. Efficacy of Artesunate-mefloquine for Chloroquine-resistant Plasmodium vivax Malaria in Malaysia: An Open-label, Randomized, Controlled Trial.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2016 06; 62(11):1403-1411. doi:
10.1093/cid/ciw121. [PMID: 27107287] - Marina Chavchich, Geoffrey W Birrell, Arba L Ager, Donna O MacKenzie, Gavin D Heffernan, Guy A Schiehser, Laura R Jacobus, G Dennis Shanks, David P Jacobus, Michael D Edstein. Lead Selection of a New Aminomethylphenol, JPC-3210, for Malaria Treatment and Prevention.
Antimicrobial agents and chemotherapy.
2016 05; 60(5):3115-8. doi:
10.1128/aac.03066-15. [PMID: 26856849] - Yi Tao, Jian Xue, Bin Jiang, Hao-Bing Zhang, Shu-Hua Xiao. Significance of higher drug concentration in erythrocytes of mice infected with Schistosoma japonicum and treated orally with mefloquine at single doses.
Parasitology research.
2015 Dec; 114(12):4521-30. doi:
10.1007/s00436-015-4696-4. [PMID: 26341799] - Johandie Gildenhuys, Chandre J Sammy, Ronel Müller, Victor A Streltsov, Tanya le Roex, David Kuter, Katherine A de Villiers. Alkoxide coordination of iron(III) protoporphyrin IX by antimalarial quinoline methanols: a key interaction observed in the solid-state and solution.
Dalton transactions (Cambridge, England : 2003).
2015 Oct; 44(38):16767-77. doi:
10.1039/c5dt02671g. [PMID: 26335948] - Kornélia Szebényi, András Füredi, Orsolya Kolacsek, Enikő Pergel, Zsuzsanna Bősze, Balázs Bender, Péter Vajdovich, József Tóvári, László Homolya, Gergely Szakács, László Héja, Ágnes Enyedi, Balázs Sarkadi, Ágota Apáti, Tamás I Orbán. Generation of a Homozygous Transgenic Rat Strain Stably Expressing a Calcium Sensor Protein for Direct Examination of Calcium Signaling.
Scientific reports.
2015 Aug; 5(?):12645. doi:
10.1038/srep12645. [PMID: 26234466] - Rithea Leang, Walter R J Taylor, Denis Mey Bouth, Lijiang Song, Joel Tarning, Meng Chuor Char, Saorin Kim, Benoit Witkowski, Valentine Duru, Anais Domergue, Nimol Khim, Pascal Ringwald, Didier Menard. Evidence of Plasmodium falciparum Malaria Multidrug Resistance to Artemisinin and Piperaquine in Western Cambodia: Dihydroartemisinin-Piperaquine Open-Label Multicenter Clinical Assessment.
Antimicrobial agents and chemotherapy.
2015 Aug; 59(8):4719-26. doi:
10.1128/aac.00835-15. [PMID: 26014949] - Suwanna Chaorattanakawee, David L Saunders, Darapiseth Sea, Nitima Chanarat, Kritsanai Yingyuen, Siratchana Sundrakes, Piyaporn Saingam, Nillawan Buathong, Sabaithip Sriwichai, Soklyda Chann, Youry Se, You Yom, Thay Kheng Heng, Nareth Kong, Worachet Kuntawunginn, Kuntida Tangthongchaiwiriya, Christopher Jacob, Shannon Takala-Harrison, Christopher Plowe, Jessica T Lin, Char Meng Chuor, Satharath Prom, Stuart D Tyner, Panita Gosi, Paktiya Teja-Isavadharm, Chanthap Lon, Charlotte A Lanteri. Ex Vivo Drug Susceptibility Testing and Molecular Profiling of Clinical Plasmodium falciparum Isolates from Cambodia from 2008 to 2013 Suggest Emerging Piperaquine Resistance.
Antimicrobial agents and chemotherapy.
2015 Aug; 59(8):4631-43. doi:
10.1128/aac.00366-15. [PMID: 26014942] - Sai Sandeep Mannemala, Janaki Sankarachari Krishnan Nagarajan. Development and validation of a generic liquid chromatographic method for the simultaneous determination of five commonly used antimalarial drugs: Application to pharmaceutical formulations and human plasma.
Journal of separation science.
2015 May; 38(9):1521-8. doi:
10.1002/jssc.201401465. [PMID: 25694118] - Vasiliy Korotchenko, Ramadas Sathunuru, Lucia Gerena, Diana Caridha, Qigui Li, Mara Kreishman-Deitrick, Philip L Smith, Ai J Lin. Antimalarial activity of 4-amidinoquinoline and 10-amidinobenzonaphthyridine derivatives.
Journal of medicinal chemistry.
2015 Apr; 58(8):3411-31. doi:
10.1021/jm501809x. [PMID: 25654185] - Marta M Wells, Tommy S Tillman, David D Mowrey, Tianmo Sun, Yan Xu, Pei Tang. Ensemble-based virtual screening for cannabinoid-like potentiators of the human glycine receptor α1 for the treatment of pain.
Journal of medicinal chemistry.
2015 Apr; 58(7):2958-2966. doi:
10.1021/jm501873p. [PMID: 25790278] - Stephanie E Reuter, Richard N Upton, Allan M Evans, Visweswaran Navaratnam, Piero L Olliaro. Population pharmacokinetics of orally administered mefloquine in healthy volunteers and patients with uncomplicated Plasmodium falciparum malaria.
The Journal of antimicrobial chemotherapy.
2015 Mar; 70(3):868-76. doi:
10.1093/jac/dku430. [PMID: 25377567] - Jason C Sousa, Erin Milner, Dustin Carroll, William McCalmont, Sean Gardner, Jay Moon, Jacob D Johnson, Patricia Lee, Jennifer Auschwitz, Norma Roncal, Diana Caridha, Anchalee Tungteung, Qiang Zeng, Sean Reyes, Bryan Smith, Qigui Li, Michael P Kozar, Victor Melendez, Geoffrey Dow. The use of a prodrug approach to minimize potential CNS exposure of next generation quinoline methanols while maintaining efficacy in in vivo animal models.
European journal of drug metabolism and pharmacokinetics.
2014 Dec; 39(4):231-6. doi:
10.1007/s13318-013-0162-9. [PMID: 24705994] - Mirjam C K Geditz, Wolfgang Lindner, Michael Lämmerhofer, Georg Heinkele, Reinhold Kerb, Michael Ramharter, Matthias Schwab, Ute Hofmann. Simultaneous quantification of mefloquine (+)- and (-)-enantiomers and the carboxy metabolite in dried blood spots by liquid chromatography/tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2014 Oct; 968(?):32-9. doi:
10.1016/j.jchromb.2013.11.035. [PMID: 24315337] - Thiago Eichi Goto, Luciano Caseli. The interaction of mefloquine hydrochloride with cell membrane models at the air-water interface is modulated by the monolayer lipid composition.
Journal of colloid and interface science.
2014 Oct; 431(?):24-30. doi:
10.1016/j.jcis.2014.05.050. [PMID: 24980622] - Wanna Chaijaroenkul, Murad A Mubaraki, Stephen A Ward, Kesara Na-Bangchang. Metabolite footprinting of Plasmodium falciparum following exposure to Garcinia mangostana Linn. crude extract.
Experimental parasitology.
2014 Oct; 145(?):80-6. doi:
10.1016/j.exppara.2014.07.013. [PMID: 25102435] - Innocent Valea, Halidou Tinto, Maminata Traore-Coulibaly, Laeticia C Toe, Niklas Lindegardh, Joel Tarning, Jean-Pierre Van Geertruyden, Umberto D'Alessandro, Geraint R Davies, Stephen A Ward. Pharmacokinetics of co-formulated mefloquine and artesunate in pregnant and non-pregnant women with uncomplicated Plasmodium falciparum infection in Burkina Faso.
The Journal of antimicrobial chemotherapy.
2014 Sep; 69(9):2499-507. doi:
10.1093/jac/dku154. [PMID: 24891429] - Christine V Kramer, Fan Zhang, David Sinclair, Piero L Olliaro. Drugs for treating urinary schistosomiasis.
The Cochrane database of systematic reviews.
2014 Aug; ?(8):CD000053. doi:
10.1002/14651858.cd000053.pub3. [PMID: 25099517] - W Armand Guiguemde, Nicholas H Hunt, Jintao Guo, Annael Marciano, Richard K Haynes, Julie Clark, R Kiplin Guy, Jacob Golenser. Treatment of murine cerebral malaria by artemisone in combination with conventional antimalarial drugs: antiplasmodial effects and immune responses.
Antimicrobial agents and chemotherapy.
2014 Aug; 58(8):4745-54. doi:
10.1128/aac.01553-13. [PMID: 24913162] - Papichaya Phompradit, Poonuch Muhamad, Anurak Cheoymang, Kesara Na-Bangchang. Preliminary investigation of the contribution of CYP2A6, CYP2B6, and UGT1A9 polymorphisms on artesunate-mefloquine treatment response in Burmese patients with Plasmodium falciparum malaria.
The American journal of tropical medicine and hygiene.
2014 Aug; 91(2):361-6. doi:
10.4269/ajtmh.13-0531. [PMID: 24891466] - Jennifer Keiser, Kigbafori D Silué, Lukas K Adiossan, Nicaise A N'Guessan, N'Chou Monsan, Jürg Utzinger, Eliézer K N'Goran. Praziquantel, mefloquine-praziquantel, and mefloquine-artesunate-praziquantel against Schistosoma haematobium: a randomized, exploratory, open-label trial.
PLoS neglected tropical diseases.
2014 Jul; 8(7):e2975. doi:
10.1371/journal.pntd.0002975. [PMID: 25033291] - Aaron Janowsky, Amy J Eshleman, Robert A Johnson, Katherine M Wolfrum, David J Hinrichs, Jongtae Yang, T Mark Zabriskie, Martin J Smilkstein, Michael K Riscoe. Mefloquine and psychotomimetics share neurotransmitter receptor and transporter interactions in vitro.
Psychopharmacology.
2014 Jul; 231(14):2771-83. doi:
10.1007/s00213-014-3446-0. [PMID: 24488404] - Vincent Jullien, Neena Valecha, Bina Srivastava, Bhawna Sharma, Jean-René Kiechel. Population pharmacokinetics of mefloquine, administered as a fixed-dose combination of artesunate-mefloquine in Indian patients for the treatment of acute uncomplicated Plasmodium falciparum malaria.
Malaria journal.
2014 May; 13(?):187. doi:
10.1186/1475-2875-13-187. [PMID: 24886117] - Lissinda H du Plessis, Chrizaan Helena, Este van Huysteen, Lubbe Wiesner, Awie F Kotzé. Formulation and evaluation of Pheroid vesicles containing mefloquine for the treatment of malaria.
The Journal of pharmacy and pharmacology.
2014 Jan; 66(1):14-22. doi:
10.1111/jphp.12147. [PMID: 24117456] - Walther H Wernsdorfer, Harald Noedl, Pamela Rendi-Wagner, Herwig Kollaritsch, Gerhard Wiedermann, Andrea Mikolasek, Juntra Karbwang, Kesara Na-Bangchang. Gender-specific distribution of mefloquine in the blood following the administration of therapeutic doses.
Malaria journal.
2013 Dec; 12(?):443. doi:
10.1186/1475-2875-12-443. [PMID: 24321055] - Nongluk Seethorn, Walther H Wernsdorfer, Harald Noedl, Juntra Karbwang, Kesara Na-Bangchang. Investigation of the in vitro gender-specific partitioning of mefloquine in malarial infected red blood cells and plasma.
The American journal of tropical medicine and hygiene.
2013 Oct; 89(4):737-41. doi:
10.4269/ajtmh.13-0328. [PMID: 24002481] - Katrin Ingram, Urs Duthaler, Mireille Vargas, William Ellis, Jennifer Keiser. Disposition of mefloquine and enpiroline is highly influenced by a chronic Schistosoma mansoni infection.
Antimicrobial agents and chemotherapy.
2013 Sep; 57(9):4506-11. doi:
10.1128/aac.01129-13. [PMID: 23836173] - Kesara Na-Bangchang, Phunuch Muhamad, Ronnatrai Ruaengweerayut, Wanna Chaijaroenkul, Juntra Karbwang. Identification of resistance of Plasmodium falciparum to artesunate-mefloquine combination in an area along the Thai-Myanmar border: integration of clinico-parasitological response, systemic drug exposure, and in vitro parasite sensitivity.
Malaria journal.
2013 Jul; 12(?):263. doi:
10.1186/1475-2875-12-263. [PMID: 23898808] - Eva Maria Staehli Hodel, Monia Guidi, Boris Zanolari, Thomas Mercier, Socheat Duong, Abdunoor M Kabanywanyi, Frédéric Ariey, Thierry Buclin, Hans-Peter Beck, Laurent A Decosterd, Piero Olliaro, Blaise Genton, Chantal Csajka. Population pharmacokinetics of mefloquine, piperaquine and artemether-lumefantrine in Cambodian and Tanzanian malaria patients.
Malaria journal.
2013 Jul; 12(?):235. doi:
10.1186/1475-2875-12-235. [PMID: 23841950] - Marco Iannetta, Anna Bellizzi, Sara Lo Menzo, Elena Anzivino, Alessandra D'Abramo, Alessandra Oliva, Claudia D'Agostino, Gabriella d'Ettorre, Valeria Pietropaolo, Vincenzo Vullo, Maria Rosa Ciardi. HIV-associated progressive multifocal leukoencephalopathy: longitudinal study of JC virus non-coding control region rearrangements and host immunity.
Journal of neurovirology.
2013 Jun; 19(3):274-9. doi:
10.1007/s13365-013-0167-9. [PMID: 23715894] - Charles O Ochieng, Lawrence A O Manguro, Philip O Owuor, Hosea Akala. Voulkensin C-E, new 11-oxocassane-type diterpenoids and a steroid glycoside from Caesalpinia volkensii stem bark and their antiplasmodial activities.
Bioorganic & medicinal chemistry letters.
2013 May; 23(10):3088-95. doi:
10.1016/j.bmcl.2013.03.007. [PMID: 23562058] - Renu Tripathi, Amber Rizvi, Swaroop Kumar Pandey, Hemlata Dwivedi, J K Saxena. Ketoconazole, a cytochrome P(450) inhibitor can potentiate the antimalarial action of α/β arteether against MDR Plasmodium yoelii nigeriensis.
Acta tropica.
2013 May; 126(2):150-5. doi:
10.1016/j.actatropica.2013.01.012. [PMID: 23391499] - Arti Basra, Ghyslain Mombo-Ngoma, Meskure Capan Melser, Daisy Akerey Diop, Heike Würbel, Jean-Rodolphe Mackanga, Moritz Fürstenau, Rella Manego Zoleko, Ayola A Adegnika, Raquel Gonzalez, Clara Menendez, Peter G Kremsner, Michael Ramharter. Efficacy of mefloquine intermittent preventive treatment in pregnancy against Schistosoma haematobium infection in Gabon: a nested randomized controlled assessor-blinded clinical trial.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2013 Mar; 56(6):e68-75. doi:
10.1093/cid/cis976. [PMID: 23175561] - Sophie Zaloumis, Andrew Humberstone, Susan A Charman, Ric N Price, Joerg Moehrle, Javier Gamo-Benito, James McCaw, Kris M Jamsen, Katherine Smith, Julie A Simpson. Assessing the utility of an anti-malarial pharmacokinetic-pharmacodynamic model for aiding drug clinical development.
Malaria journal.
2012 Aug; 11(?):303. doi:
10.1186/1475-2875-11-303. [PMID: 22931058] - Milkyas Endale, Annabel Ekberg, Hoseah M Akala, John Patrick Alao, Per Sunnerhagen, Abiy Yenesew, Máté Erdélyi. Busseihydroquinones A-D from the roots of Pentas bussei.
Journal of natural products.
2012 Jul; 75(7):1299-304. doi:
10.1021/np3002223. [PMID: 22709138] - Shu-hua Xiao, Jian Xue, Hao-bing Zhang. Further studies on mefloquine and praziquantel alone or interaction of both drugs against Schistosoma japonicum in vitro.
Parasitology research.
2012 Mar; 110(3):1239-48. doi:
10.1007/s00436-011-2621-z. [PMID: 21853223] - Grace O Gbotosho, Christian T Happi, Omowunmi Lawal, Abayomi Sijuade, Akin Sowunmi, Ayoade Oduola. A high performance liquid chromatographic assay of mefloquine in saliva after a single oral dose in healthy adult Africans.
Malaria journal.
2012 Feb; 11(?):59. doi:
10.1186/1475-2875-11-59. [PMID: 22369125] - Shu-Hua Xiao, Jun Sun, Jian Xue, Xi-Ling Du, Hao-Bing Zhang. Ultrastructural alterations of juvenile Schistosoma japonicum harbored in mice following mefloquine administration.
Parasitology research.
2012 Feb; 110(2):637-44. doi:
10.1007/s00436-011-2534-x. [PMID: 21750873] - Sunanta Tangnitipong, Thitiporn Thaptimthong, Sirada Srihirun, Supeenun Unchern, Dusadee Kittikool, Rachanee Udomsangpetch, Nathawut Sibmooh. Extracellular heme enhances the antimalarial activity of artemisinin.
Biological & pharmaceutical bulletin.
2012; 35(1):29-33. doi:
10.1248/bpb.35.29. [PMID: 22223333] - Patricia Schlagenhauf, Miriam Adamcova, Loredana Regep, Martin T Schaerer, Sudhir Bansod, Hans-Georg Rhein. Use of mefloquine in children - a review of dosage, pharmacokinetics and tolerability data.
Malaria journal.
2011 Oct; 10(?):292. doi:
10.1186/1475-2875-10-292. [PMID: 21981927] - Geoffrey S Dow, Montip Gettayacamin, Pranee Hansukjariya, Rawiwan Imerbsin, Srawuth Komcharoen, Jetsumon Sattabongkot, Dennis Kyle, Wilbur Milhous, Simon Cozens, David Kenworthy, Anne Miller, Jim Veazey, Colin Ohrt. Radical curative efficacy of tafenoquine combination regimens in Plasmodium cynomolgi-infected Rhesus monkeys (Macaca mulatta).
Malaria journal.
2011 Jul; 10(?):212. doi:
10.1186/1475-2875-10-212. [PMID: 21801400] - Kesara Na-Bangchang, Ronnatrai Ruengweerayut, Walther H Wernsdorfer. Distribution of mefloquine in the blood of Thai patients with acute uncomplicated falciparum malaria following administration of therapeutic doses of artesunate.
European journal of clinical pharmacology.
2011 Jul; 67(7):687-91. doi:
10.1007/s00228-011-1058-8. [PMID: 21556929] - Ramesh Gujjar, Farah El Mazouni, Karen L White, John White, Sharon Creason, David M Shackleford, Xiaoyi Deng, William N Charman, Ian Bathurst, Jeremy Burrows, David M Floyd, David Matthews, Frederick S Buckner, Susan A Charman, Margaret A Phillips, Pradipsinh K Rathod. Lead optimization of aryl and aralkyl amine-based triazolopyrimidine inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice.
Journal of medicinal chemistry.
2011 Jun; 54(11):3935-49. doi:
10.1021/jm200265b. [PMID: 21517059] - Geoffrey S Dow, Erin Milner, Ian Bathurst, Jayendra Bhonsle, Diana Caridha, Sean Gardner, Lucia Gerena, Michael Kozar, Charlotte Lanteri, Anne Mannila, William McCalmont, Jay Moon, Kevin D Read, Suzanne Norval, Norma Roncal, David M Shackleford, Jason Sousa, Jessica Steuten, Karen L White, Qiang Zeng, Susan A Charman. Central nervous system exposure of next generation quinoline methanols is reduced relative to mefloquine after intravenous dosing in mice.
Malaria journal.
2011 Jun; 10(?):150. doi:
10.1186/1475-2875-10-150. [PMID: 21645370] - C Slabbert, L H du Plessis, A F Kotzé. Evaluation of the physical properties and stability of two lipid drug delivery systems containing mefloquine.
International journal of pharmaceutics.
2011 May; 409(1-2):209-15. doi:
10.1016/j.ijpharm.2011.01.050. [PMID: 21310223] - Angélica López-Izquierdo, Daniela Ponce-Balbuena, Eloy G Moreno-Galindo, Iván A Aréchiga-Figueroa, Martín Rodríguez-Martínez, Tania Ferrer, Aldo A Rodríguez-Menchaca, José A Sánchez-Chapula. The antimalarial drug mefloquine inhibits cardiac inward rectifier K+ channels: evidence for interference in PIP2-channel interaction.
Journal of cardiovascular pharmacology.
2011 Apr; 57(4):407-15. doi:
10.1097/fjc.0b013e31820b7c03. [PMID: 21502926] - Shubhra Singh, Rajeev Kumar Srivastava, Mukesh Srivastava, S K Puri, K Srivastava. In-vitro culture of Plasmodium falciparum: utility of modified (RPNI) medium for drug-sensitivity studies using SYBR Green I assay.
Experimental parasitology.
2011 Jan; 127(1):318-21. doi:
10.1016/j.exppara.2010.08.007. [PMID: 20727351] - Kaijun Luo, Matthew W Turnbull. Characterization of nonjunctional hemichannels in caterpillar cells.
Journal of insect science (Online).
2011; 11(?):6. doi:
10.1673/031.011.0106. [PMID: 21521140] - Kesara Na-Bangchang, Ronnatrai Ruengweerayut, Poonuch Mahamad, Kulaya Ruengweerayut, Wanna Chaijaroenkul. Declining in efficacy of a three-day combination regimen of mefloquine-artesunate in a multi-drug resistance area along the Thai-Myanmar border.
Malaria journal.
2010 Oct; 9(?):273. doi:
10.1186/1475-2875-9-273. [PMID: 20929590] - Eva Maria Hodel, Blaise Genton, Boris Zanolari, Thomas Mercier, Socheat Duong, Hans-Peter Beck, Piero Olliaro, Laurent Arthur Decosterd, Frédéric Ariey. Residual antimalarial concentrations before treatment in patients with malaria from Cambodia: indication of drug pressure.
The Journal of infectious diseases.
2010 Oct; 202(7):1088-94. doi:
10.1086/655779. [PMID: 20726764] - S Krudsood, S Looareesuwan, N Tangpukdee, P Wilairatana, W Phumratanaprapin, W Leowattana, K Chalermrut, S Ramanathan, V Navaratnam, P Olliaro, M Vaillant, J R Kiechel, W R J Taylor. New fixed-dose artesunate-mefloquine formulation against multidrug-resistant Plasmodium falciparum in adults: a comparative phase IIb safety and pharmacokinetic study with standard-dose nonfixed artesunate plus mefloquine.
Antimicrobial agents and chemotherapy.
2010 Sep; 54(9):3730-7. doi:
10.1128/aac.01187-09. [PMID: 20547795] - Elodie Descloux, Frédérique De Monbrison, Cécile Basselin, Thierry Vial, François Peyron. Mefloquine adverse effects with atypical facial lesions in an overweight patient.
Travel medicine and infectious disease.
2010 Sep; 8(5):318-21. doi:
10.1016/j.tmaid.2010.06.003. [PMID: 20971443] - Nathalie Wurtz, Sébastien Briolant, Marine Gil, Véronique Parquet, Maud Henry, Eric Baret, Rémy Amalvict, Lionel Almeras, Christophe Rogier, Bruno Pradines. Synergy of mefloquine activity with atorvastatin, but not chloroquine and monodesethylamodiaquine, and association with the pfmdr1 gene.
The Journal of antimicrobial chemotherapy.
2010 Jul; 65(7):1387-94. doi:
10.1093/jac/dkq173. [PMID: 20501488] - Shu-hua Xiao, Jian Xue, Binggui Shen. Transmission electron microscopic observation on ultrastructural alterations in Schistosoma japonicum caused by mefloquine.
Parasitology research.
2010 Apr; 106(5):1179-87. doi:
10.1007/s00436-010-1782-5. [PMID: 20174826] - Kanungnit Congpuong, Pongwit Bualombai, Vick Banmairuroi, Kesara Na-Bangchang. Compliance with a three-day course of artesunate-mefloquine combination and baseline anti-malarial treatment in an area of Thailand with highly multidrug resistant falciparum malaria.
Malaria journal.
2010 Feb; 9(?):43. doi:
10.1186/1475-2875-9-43. [PMID: 20132537] - Shu-Hua Xiao, Jing-Yan Mei, Pei-Ying Jiao. The in vitro effect of mefloquine and praziquantel against juvenile and adult Schistosoma japonicum.
Parasitology research.
2009 Dec; 106(1):237-46. doi:
10.1007/s00436-009-1656-x. [PMID: 19851783] - Miguel Prudêncio, Elvira T Derbyshire, Catarina A Marques, Sanjeev Krishna, Maria M Mota, Henry M Staines. Plasmodium berghei-infection induces volume-regulated anion channel-like activity in human hepatoma cells.
Cellular microbiology.
2009 Oct; 11(10):1492-501. doi:
10.1111/j.1462-5822.2009.01342.x. [PMID: 19496788] - John A Lewis, Maria Szilagyi, Elizabeth Gehman, William E Dennis, David A Jackson. Distinct patterns of gene and protein expression elicited by organophosphorus pesticides in Caenorhabditis elegans.
BMC genomics.
2009 Apr; 10(?):202. doi:
10.1186/1471-2164-10-202. [PMID: 19402892] - Julie Gutman, Michael Green, Salomon Durand, Ofelia Villalva Rojas, Babita Ganguly, Wilmer Marquiño Quezada, Gregory C Utz, Laurence Slutsker, Trenton K Ruebush, David J Bacon. Mefloquine pharmacokinetics and mefloquine-artesunate effectiveness in Peruvian patients with uncomplicated Plasmodium falciparum malaria.
Malaria journal.
2009 Apr; 8(?):58. doi:
10.1186/1475-2875-8-58. [PMID: 19358697] - Patrice Njomnang Soh, Benoît Witkowski, David Olagnier, Marie-Laure Nicolau, Maria-Concepcion Garcia-Alvarez, Antoine Berry, Françoise Benoit-Vical. In vitro and in vivo properties of ellagic acid in malaria treatment.
Antimicrobial agents and chemotherapy.
2009 Mar; 53(3):1100-6. doi:
10.1128/aac.01175-08. [PMID: 19015354] - Igor Rafael dos Santos Magalhães, Pierina Sueli Bonato. Two-step liquid-phase microextraction and high-performance liquid chromatography for the simultaneous analysis of the enantiomers of mefloquine and its main metabolite carboxymefloquine in plasma.
Analytical and bioanalytical chemistry.
2009 Mar; 393(6-7):1805-13. doi:
10.1007/s00216-009-2620-4. [PMID: 19184594] - Sylvie Barraud de Lagerie, Christine Fernandez, Michèle German-Fattal, Jean-Charles Gantier, François Gimenez, Robert Farinotti. Impact of cerebral malaria on brain distribution of mefloquine.
Drug metabolism letters.
2009 Jan; 3(1):15-7. doi:
10.2174/187231209787176407. [PMID: 19356112] - Esther Castanys-Muñoz, José María Pérez-Victoria, Francisco Gamarro, Santiago Castanys. Characterization of an ABCG-like transporter from the protozoan parasite Leishmania with a role in drug resistance and transbilayer lipid movement.
Antimicrobial agents and chemotherapy.
2008 Oct; 52(10):3573-9. doi:
10.1128/aac.00587-08. [PMID: 18644961] - Igor Rafael dos Santos Magalhães, Pierina Sueli Bonato. Liquid-phase microextraction combined with high-performance liquid chromatography for the enantioselective analysis of mefloquine in plasma samples.
Journal of pharmaceutical and biomedical analysis.
2008 Apr; 46(5):929-36. doi:
10.1016/j.jpba.2007.01.043. [PMID: 17367978]
