Taurolithocholic acid 3-sulfate (BioDeep_00001868517)
Main id: BioDeep_00000001698
Bile acids
代谢物信息卡片
化学式: C26H45NO8S2 (563.2586)
中文名称: 牛磺石胆酸-3-硫酸酯
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(CCC(=O)NCCS(=O)(=O)O)C1CCC2C1(CCC3C2CCC4C3(CCC(C4)OS(=O)(=O)O)C)C
InChI: InChI=1S/C26H45NO8S2/c1-17(4-9-24(28)27-14-15-36(29,30)31)21-7-8-22-20-6-5-18-16-19(35-37(32,33)34)10-12-25(18,2)23(20)11-13-26(21,22)3/h17-23H,4-16H2,1-3H3,(H,27,28)(H,29,30,31)(H,32,33,34)/t17-,18-,19-,20+,21-,22+,23+,25+,26-/m1/s1
描述信息
D005765 - Gastrointestinal Agents > D001647 - Bile Acids and Salts
D005765 - Gastrointestinal Agents > D002793 - Cholic Acids
同义名列表
18 个代谢物同义名
Taurolithocholic acid 3-sulfate; Taurolithocholate sulfate; (3alpha-sulfato-5beta-cholan-24-oyl)-2'-aminoethanesulfonate; 2-[(24-oxo-3alpha-sulfooxy-5beta-cholan-24-yl)amino]ethanesulfonic acid; 2-[[(3alpha,5beta)-24-oxo-3-(sulfooxy)cholan-24-yl]amino]-ethanesulfonic acid; 2-[[(4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-3-sulfooxy-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]ethanesulfonic acid; 3alpha-sulfatolithocholyltaurine; N-(3alpha-hydroxy-5beta-cholan-24-oyl)-taurine 3-sulfate; Slct-3-sulfate; Slct-3-sulphate; ST 24:1;O3;T;S; taurolithocholate 3-sulfate; Taurolithocholate 3-sulphate; Taurolithocholate sulphate; Taurolithocholic acid 3-sulphate; taurolithocholic acid sulfate; Taurolithocholic acid sulphate; TLC-S
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:17864
- KEGG: C03642
- PubChem: 440071
- ChEMBL: CHEMBL270493
- CAS: 15324-65-9
- PubChem: 6424
- LipidMAPS: LMST05020003
- 3DMET: B01678
- NIKKAJI: J682.199E
- RefMet: Taurolithocholic acid 3-sulfate
- KNApSAcK: 17864
- MeSH: taurolithocholic acid 3-sulfate
分类词条
相关代谢途径
Reactome(7)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
- 9606 - Homo sapiens: 10.1007/S11306-016-1051-4
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Francesca De Faveri, Michael Chvanov, Svetlana Voronina, Danielle Moore, Liam Pollock, Lee Haynes, Muhammad Awais, Alison J Beckett, Ulrike Mayer, Robert Sutton, David N Criddle, Ian A Prior, Tom Wileman, Alexei V Tepikin. LAP-like non-canonical autophagy and evolution of endocytic vacuoles in pancreatic acinar cells.
Autophagy.
2020 07; 16(7):1314-1331. doi:
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The Journal of biological chemistry.
2019 08; 294(31):11853-11862. doi:
10.1074/jbc.ra118.007179. [PMID: 31201272] - Issey Takehara, Nobuaki Watanabe, Daiki Mori, Osamu Ando, Hiroyuki Kusuhara. Effect of Rifampicin on the Plasma Concentrations of Bile Acid-O-Sulfates in Monkeys and Human Liver-Transplanted Chimeric Mice With or Without Bile Flow Diversion.
Journal of pharmaceutical sciences.
2019 08; 108(8):2756-2764. doi:
10.1016/j.xphs.2019.03.021. [PMID: 30905707] - Thomas R Kolodecik, Anamika M Reed, Kimie Date, Christine A Shugrue, Vikhil Patel, Shang-Lin Chung, Gary V Desir, Fred S Gorelick. The serum protein renalase reduces injury in experimental pancreatitis.
The Journal of biological chemistry.
2017 12; 292(51):21047-21059. doi:
10.1074/jbc.m117.789776. [PMID: 29042438] - Shishuai Meng, Hao Wang, Dongbo Xue, Weihui Zhang. Screening and validation of differentially expressed extracellular miRNAs in acute pancreatitis.
Molecular medicine reports.
2017 Nov; 16(5):6412-6418. doi:
10.3892/mmr.2017.7374. [PMID: 28849189] - Wei Huang, Andrea C Haynes, Rajarshi Mukherjee, Li Wen, Diane Latawiec, Alexei V Tepikin, David N Criddle, Rab K Prinjha, Nicholas Smithers, Robert Sutton. Selective inhibition of BET proteins reduces pancreatic damage and systemic inflammation in bile acid- and fatty acid ethyl ester- but not caerulein-induced acute pancreatitis.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.].
2017 Sep; 17(5):689-697. doi:
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Gut.
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10.1136/gutjnl-2015-309363. [PMID: 26642860] - Wei Huang, Nicole Cash, Li Wen, Peter Szatmary, Rajarshi Mukherjee, Jane Armstrong, Michael Chvanov, Alexei V Tepikin, Michael P Murphy, Robert Sutton, David N Criddle. Effects of the mitochondria-targeted antioxidant mitoquinone in murine acute pancreatitis.
Mediators of inflammation.
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10.1155/2015/901780. [PMID: 25878403] - Julia V Gerasimenko, Sarah E Flowerdew, Svetlana G Voronina, Tatiana K Sukhomlin, Alexei V Tepikin, Ole H Petersen, Oleg V Gerasimenko. Bile acids induce Ca2+ release from both the endoplasmic reticulum and acidic intracellular calcium stores through activation of inositol trisphosphate receptors and ryanodine receptors.
The Journal of biological chemistry.
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The Journal of biological chemistry.
2005 Mar; 280(10):8945-50. doi:
10.1074/jbc.m414354200. [PMID: 15634668] - Dirk Graf, Roland Reinehr, Anna Kordelia Kurz, Richard Fischer, Dieter Häussinger. Inhibition of taurolithocholate 3-sulfate-induced apoptosis by cyclic AMP in rat hepatocytes involves protein kinase A-dependent and -independent mechanisms.
Archives of biochemistry and biophysics.
2003 Jul; 415(1):34-42. doi:
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Hepatology (Baltimore, Md.).
2002 Oct; 36(4 Pt 1):829-39. doi:
10.1053/jhep.2002.35536. [PMID: 12297830] - Dirk Graf, Anna Kordelia Kurz, Richard Fischer, Roland Reinehr, Dieter Häussinger. Taurolithocholic acid-3 sulfate induces CD95 trafficking and apoptosis in a c-Jun N-terminal kinase-dependent manner.
Gastroenterology.
2002 May; 122(5):1411-27. doi:
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The Journal of biological chemistry.
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". [PMID: 7595095]
