Brinzolamide (BioDeep_00001867990)

Main id: BioDeep_00000006594

 

Volatile Flavor Compounds


代谢物信息卡片


Brinzolamide

化学式: C12H21N3O5S3 (383.0643296)
中文名称: 布林佐胺
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCNC1CN(S(=O)(=O)C2=C1C=C(S2)S(=O)(=O)N)CCCOC
InChI: InChI=1S/C12H21N3O5S3/c1-3-14-10-8-15(5-4-6-20-2)23(18,19)12-9(10)7-11(21-12)22(13,16)17/h7,10,14H,3-6,8H2,1-2H3,(H2,13,16,17)/t10-/m0/s1

描述信息

S - Sensory organs > S01 - Ophthalmologicals > S01E - Antiglaucoma preparations and miotics > S01EC - Carbonic anhydrase inhibitors
C78283 - Agent Affecting Organs of Special Senses > C29705 - Anti-glaucoma Agent
D004791 - Enzyme Inhibitors > D002257 - Carbonic Anhydrase Inhibitors
C471 - Enzyme Inhibitor > C29577 - Carbonic Anhydrase Inhibitor

同义名列表

2 个代谢物同义名

Brinzolamide; Brinzolamide



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Liping Chen, Ruixin Wu. Brinzolamide- and latanoprost-loaded nano lipid carrier prevents synergistic retinal damage in glaucoma. Acta biochimica Polonica. 2022 May; 69(2):423-428. doi: 10.18388/abp.2020_5885. [PMID: 35617132]
  • Gen Suzuki, Eriko Kunikane, Wakasa Shigemi, Keisuke Shinno, Seiko Kozai, Masaaki Kurata, Akio Kawamura. Ocular and systemic pharmacokinetics of brimonidine and brinzolamide after topical administration in rabbits: comparison between fixed-combination and single-drug formulations. Current eye research. 2021 03; 46(3):380-386. doi: 10.1080/02713683.2020.1800046. [PMID: 32706598]
  • Vatsala Naageshwaran, Veli-Pekka Ranta, Glenwood Gum, Siddhartha Bhoopathy, Arto Urtti, Eva M Del Amo. Comprehensive Ocular and Systemic Pharmacokinetics of Brinzolamide in Rabbits After Intracameral, Topical, and Intravenous Administration. Journal of pharmaceutical sciences. 2021 01; 110(1):529-535. doi: 10.1016/j.xphs.2020.09.051. [PMID: 33035542]
  • Nupur Shrivastava, Saba Khan, Sanjula Baboota, Javed Ali. Fabrication and Characterization of Timolol Maleate and Brinzolamide Loaded Nanostructured Lipid Carrier System for Ocular Drug Delivery. Current drug delivery. 2018; 15(6):829-839. doi: 10.2174/1566523218666171129205626. [PMID: 29189155]
  • Alexandra Robciuc, Joanna Witos, Suvi-Katriina Ruokonen, Antti H Rantamäki, Pierre-Jean Pisella, Susanne K Wiedmer, Juha M Holopainen. Pure Glaucoma Drugs Are Toxic to Immortalized Human Corneal Epithelial Cells, but They Do Not Destabilize Lipid Membranes. Cornea. 2017 Oct; 36(10):1249-1255. doi: 10.1097/ico.0000000000001322. [PMID: 28825921]
  • Anargyros Foivas, Anđelija Malenović, Nađa Kostić, Marija Božić, Miroslav Knežević, Yannis L Loukas, Yannis Dotsikas. Quantitation of brinzolamide in dried blood spots by a novel LC-QTOF-MS/MS method. Journal of pharmaceutical and biomedical analysis. 2016 Feb; 119(?):84-90. doi: 10.1016/j.jpba.2015.11.043. [PMID: 26669612]
  • Billie Beckwith-Cohen, Ellison Bentley, David J Gasper, Gillian J McLellan, Richard R Dubielzig. Keratitis in six dogs after topical treatment with carbonic anhydrase inhibitors for glaucoma. Journal of the American Veterinary Medical Association. 2015 Dec; 247(12):1419-26. doi: 10.2460/javma.247.12.1419. [PMID: 26642138]
  • Imran Ali, Zeid A Al-Othman, Abdulrahman Al-Warthan, Syed Dilshad Alam, Javed A Farooqi. Enantiomeric separation and simulation studies of pheniramine, oxybutynin, cetirizine, and brinzolamide chiral drugs on amylose-based columns. Chirality. 2014 Mar; 26(3):136-43. doi: 10.1002/chir.22276. [PMID: 24464520]
  • Rajendra S Kadam, Gajanan Jadhav, Miller Ogidigben, Uday B Kompella. Ocular pharmacokinetics of dorzolamide and brinzolamide after single and multiple topical dosing: implications for effects on ocular blood flow. Drug metabolism and disposition: the biological fate of chemicals. 2011 Sep; 39(9):1529-37. doi: 10.1124/dmd.111.040055. [PMID: 21673129]
  • Jorge A Alvarado, Rumiko Iguchi, Richard Juster, Julie A Chen, Amde Selassie Shifera. From the bedside to the bench and back again: predicting and improving the outcomes of SLT glaucoma therapy. Transactions of the American Ophthalmological Society. 2009 Dec; 107(?):167-81. doi: . [PMID: 20126493]
  • Mika Hilvo, Anna Maria Salzano, Alessio Innocenti, Markku S Kulomaa, Andrea Scozzafava, Andrea Scaloni, Seppo Parkkila, Claudiu T Supuran. Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. Journal of medicinal chemistry. 2009 Feb; 52(3):646-54. doi: 10.1021/jm801267c. [PMID: 19193158]
  • Benjamin Bakall, Precious McLaughlin, J Brett Stanton, Youwen Zhang, H Criss Hartzell, Lihua Y Marmorstein, Alan D Marmorstein. Bestrophin-2 is involved in the generation of intraocular pressure. Investigative ophthalmology & visual science. 2008 Apr; 49(4):1563-70. doi: 10.1167/iovs.07-1338. [PMID: 18385076]
  • Diana Melinte Dumitrica, C Stefan. [Open-angle glaucoma associated with Groenblad-Strandberg syndrome]. Oftalmologia (Bucharest, Romania : 1990). 2008; 52(4):44-52. doi: ". [PMID: 19354162]
  • M F Sugrue. Pharmacological and ocular hypotensive properties of topical carbonic anhydrase inhibitors. Progress in retinal and eye research. 2000 Jan; 19(1):87-112. doi: 10.1016/s1350-9462(99)00006-3. [PMID: 10614682]
  • A Scozzafava, F Briganti, G Mincione, L Menabuoni, F Mincione, C T Supuran. Carbonic anhydrase inhibitors: synthesis of water-soluble, aminoacyl/dipeptidyl sulfonamides possessing long-lasting intraocular pressure-lowering properties via the topical route. Journal of medicinal chemistry. 1999 Sep; 42(18):3690-700. doi: 10.1021/jm9901879. [PMID: 10479300]
  • A Scozzafava, L Menabuoni, F Mincione, F Briganti, G Mincione, C T Supuran. Carbonic anhydrase inhibitors. Synthesis of water-soluble, topically effective, intraocular pressure-lowering aromatic/heterocyclic sulfonamides containing cationic or anionic moieties: is the tail more important than the ring?. Journal of medicinal chemistry. 1999 Jul; 42(14):2641-50. doi: 10.1021/jm9900523. [PMID: 10411484]
  • T Stams, Y Chen, P A Boriack-Sjodin, J D Hurt, J Liao, J A May, T Dean, P Laipis, D N Silverman, D W Christianson. Structures of murine carbonic anhydrase IV and human carbonic anhydrase II complexed with brinzolamide: molecular basis of isozyme-drug discrimination. Protein science : a publication of the Protein Society. 1998 Mar; 7(3):556-63. doi: 10.1002/pro.5560070303. [PMID: 9541386]