dicyclomine (BioDeep_00001867877)

Main id: BioDeep_00000002372

 


代谢物信息卡片


dicyclomine

化学式: C19H35NO2 (309.266765)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCN(CC)CCOC(=O)C1(CCCCC1)C2CCCCC2
InChI: InChI=1S/C19H35NO2/c1-3-20(4-2)15-16-22-18(21)19(13-9-6-10-14-19)17-11-7-5-8-12-17/h17H,3-16H2,1-2H3

描述信息

A - Alimentary tract and metabolism > A03 - Drugs for functional gastrointestinal disorders > A03A - Drugs for functional gastrointestinal disorders > A03AA - Synthetic anticholinergics, esters with tertiary amino group
C78272 - Agent Affecting Nervous System > C66880 - Anticholinergic Agent > C29704 - Antimuscarinic Agent
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D010276 - Parasympatholytics
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D018680 - Cholinergic Antagonists

同义名列表

1 个代谢物同义名

dicyclomine



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Syed Adil Hussain Shah, Ambreen Aleem. Investigations of plausible pharmacodynamics supporting the antispasmodic, bronchodilator, and antidiarrheal activities of Berberis lycium Royle. Via in silico, in vitro, and in vivo studies. Journal of ethnopharmacology. 2023 Apr; 305(?):116115. doi: 10.1016/j.jep.2022.116115. [PMID: 36587881]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Arpita Konar, Richa Gupta, Rajendra K Shukla, Bryan Maloney, Vinay K Khanna, Renu Wadhwa, Debomoy K Lahiri, Mahendra K Thakur. M1 muscarinic receptor is a key target of neuroprotection, neuroregeneration and memory recovery by i-Extract from Withania somnifera. Scientific reports. 2019 Sep; 9(1):13990. doi: 10.1038/s41598-019-48238-6. [PMID: 31570736]
  • Awad Ali, Ashwini Jadhav, Priyanka Jangid, Rajendra Patil, Amruta Shelar, Sankunny Mohan Karuppayil. The human muscarinic acetylcholine receptor antagonist, Dicyclomine targets signal transduction genes and inhibits the virulence factors in the human pathogen, Candida albicans. The Journal of antibiotics. 2018 03; 71(4):456-466. doi: 10.1038/s41429-017-0013-z. [PMID: 29348527]
  • Shahrukh Ali, Muhammad Ovais Omer, Mueen Ahmad Chaudhry, Muhammad Ashraf, Allah Bukhsh. A pharmacological evidence for the presence of antihistaminic and anticholinergic activities in Equisetum debile Roxb. Indian journal of pharmacology. 2017 Jan; 49(1):98-101. doi: 10.4103/0253-7613.201017. [PMID: 28458431]
  • Ilan Matok, Shannon Clark, Steve Caritis, Menachem Miodovnik, Jason G Umans, Gary Hankins, Donald R Mattison, Gideon Koren. Studying the antiemetic effect of vitamin B6 for morning sickness: pyridoxine and pyridoxal are prodrugs. Journal of clinical pharmacology. 2014 Dec; 54(12):1429-33. doi: 10.1002/jcph.369. [PMID: 25052410]
  • Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2332-41. doi: 10.1124/dmd.112.047068. [PMID: 22961681]
  • Najeeb-ur-Rehman, Samra Bashir, Adnan J Al-Rehaily, Anwarul-Hassan Gilani. Mechanisms underlying the antidiarrheal, antispasmodic and bronchodilator activities of Fumaria parviflora and involvement of tissue and species specificity. Journal of ethnopharmacology. 2012 Oct; 144(1):128-37. doi: 10.1016/j.jep.2012.08.039. [PMID: 22975416]
  • Najeeb-ur Rehman, Malik Hassan Mehmood, Khalid M Alkharfy, Anwarul-Hassan Gilani. Studies on antidiarrheal and antispasmodic activities of Lepidium sativum crude extract in rats. Phytotherapy research : PTR. 2012 Jan; 26(1):136-41. doi: 10.1002/ptr.3642. [PMID: 22006354]
  • Imran Imran, Liaqat Hussain, M Zia-Ul-Haq, Khalid Hussain Janbaz, Anwar H Gilani, Vincenzo De Feo. Gastrointestial and respiratory activities of Acacia leucophloea. Journal of ethnopharmacology. 2011 Dec; 138(3):676-82. doi: 10.1016/j.jep.2011.09.019. [PMID: 21959184]
  • Kajsa Landgren, Nina Kvorning, Inger Hallström. Feeding, stooling and sleeping patterns in infants with colic--a randomized controlled trial of minimal acupuncture. BMC complementary and alternative medicine. 2011 Oct; 11(?):93. doi: 10.1186/1472-6882-11-93. [PMID: 21989212]
  • Yasuto Kido, Pär Matsson, Kathleen M Giacomini. Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2. Journal of medicinal chemistry. 2011 Jul; 54(13):4548-58. doi: 10.1021/jm2001629. [PMID: 21599003]
  • Malik Hassan Mehmood, Hasan Salman Siddiqi, Anwarul Hassan Gilani. The antidiarrheal and spasmolytic activities of Phyllanthus emblica are mediated through dual blockade of muscarinic receptors and Ca2+ channels. Journal of ethnopharmacology. 2011 Jan; 133(2):856-65. doi: 10.1016/j.jep.2010.11.023. [PMID: 21093572]
  • Kelly E Steidl, William Darko, Luke A Probst, John A Noviasky, Samer Nasser. Rhabdomyolysis associated with phentermine. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists. 2010 Nov; 67(22):1929-32. doi: 10.2146/ajhp090395. [PMID: 21048209]
  • Arif-ullah Khan, Anwarul Hassan Gilani. Antispasmodic and bronchodilator activities of Artemisia vulgaris are mediated through dual blockade of muscarinic receptors and calcium influx. Journal of ethnopharmacology. 2009 Dec; 126(3):480-6. doi: 10.1016/j.jep.2009.09.010. [PMID: 19751814]
  • Francisco Botella Romero, Elisa Martín Montañez, Eugenio Jiménez Gutiérrez, José Pavía Molina. [Characterization of muscarinic receptors in undifferentiated thyroid cells in Fisher rats]. Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion. 2009 Mar; 56(3):106-11. doi: 10.1016/s1575-0922(09)70839-3. [PMID: 19627722]
  • Grace Guzman, Eric R Kallwitz, Christina Wojewoda, Rohini Chennuri, Jamie Berkes, Thomas J Layden, Scott J Cotler. Liver Injury with Features Mimicking Autoimmune Hepatitis following the Use of Black Cohosh. Case reports in medicine. 2009; 2009(?):918156. doi: 10.1155/2009/918156. [PMID: 20130783]
  • Alexander C Ford, Nicholas J Talley, Brennan M R Spiegel, Amy E Foxx-Orenstein, Lawrence Schiller, Eamonn M M Quigley, Paul Moayyedi. Effect of fibre, antispasmodics, and peppermint oil in the treatment of irritable bowel syndrome: systematic review and meta-analysis. BMJ (Clinical research ed.). 2008 Nov; 337(?):a2313. doi: 10.1136/bmj.a2313. [PMID: 19008265]
  • Marci L Chew, Benoit H Mulsant, Bruce G Pollock, Mark E Lehman, Andrew Greenspan, Ramy A Mahmoud, Margaret A Kirshner, Denise A Sorisio, Robert R Bies, Georges Gharabawi. Anticholinergic activity of 107 medications commonly used by older adults. Journal of the American Geriatrics Society. 2008 Jul; 56(7):1333-41. doi: 10.1111/j.1532-5415.2008.01737.x. [PMID: 18510583]
  • Anwarul Hassan Gilani, Arif-Ullah Khan, Tuba Ali, Saad Ajmal. Mechanisms underlying the antispasmodic and bronchodilatory properties of Terminalia bellerica fruit. Journal of ethnopharmacology. 2008 Mar; 116(3):528-38. doi: 10.1016/j.jep.2008.01.006. [PMID: 18289813]
  • Anwarul Hassan Gilani, Arif-Ullah Khan, Mustafa Raoof, Muhammad Nabeel Ghayur, Bina S Siddiqui, Waseem Vohra, Sabira Begum. Gastrointestinal, selective airways and urinary bladder relaxant effects of Hyoscyamus niger are mediated through dual blockade of muscarinic receptors and Ca2+ channels. Fundamental & clinical pharmacology. 2008 Feb; 22(1):87-99. doi: 10.1111/j.1472-8206.2007.00561.x. [PMID: 18251725]
  • Hosny Ibrahim, Y M Issa, Hazem M Abu-Shawish. Improving the detection limits of antispasmodic drugs electrodes by using modified membrane sensors with inner solid contact. Journal of pharmaceutical and biomedical analysis. 2007 May; 44(1):8-15. doi: 10.1016/j.jpba.2007.01.018. [PMID: 17383844]
  • David Rp Guay. Trospium chloride: an update on a quaternary anticholinergic for treatment of urge urinary incontinence. Therapeutics and clinical risk management. 2005 Jun; 1(2):157-67. doi: 10.2147/tcrm.1.2.157.62912. [PMID: 18360555]
  • Lining Qi, Neil D Danielson. Quantitative determination of pharmaceuticals using nano-electrospray ionization mass spectrometry after reversed phase mini-solid phase extraction. Journal of pharmaceutical and biomedical analysis. 2005 Feb; 37(2):225-30. doi: 10.1016/j.jpba.2004.09.023. [PMID: 15708661]
  • Irina Alexandrovich, Olga Rakovitskaya, Elena Kolmo, Tatyana Sidorova, Sergei Shushunov. The effect of fennel (Foeniculum Vulgare) seed oil emulsion in infantile colic: a randomized, placebo-controlled study. Alternative therapies in health and medicine. 2003 Jul; 9(4):58-61. doi: ". [PMID: 12868253]
  • J H Evans. Evidence based management of nocturnal enuresis. BMJ (Clinical research ed.). 2001 Nov; 323(7322):1167-9. doi: 10.1136/bmj.323.7322.1167. [PMID: 11711411]
  • E Jiménez, J Pavía, V Morell, E Martín, M Montiel. Muscarinic receptor subtypes and calcium signaling in Fischer rat thyroid cells. Biochemical pharmacology. 2001 Feb; 61(3):337-42. doi: 10.1016/s0006-2952(00)00565-7. [PMID: 11172738]
  • J Pavía, M Muñoz, E Jiménez, F Martos, J A Gonzalez-Correa, J P De la Cruz, V Garcia, F Sanchez de la Cuesta. Pharmacological characterization and distribution of muscarinic receptors in human placental syncytiotrophoblast brush-border and basal plasma membranes. European journal of pharmacology. 1997 Feb; 320(2-3):209-14. doi: 10.1016/s0014-2999(96)00889-8. [PMID: 9059856]
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