microcystin-LR (BioDeep_00001867751)

Main id: BioDeep_00000002207

 


代谢物信息卡片


microcystin-LR

化学式: C49H74N10O12 (994.5487404)
中文名称: 微囊藻毒素Microcystin-LR
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1C(NC(=O)C(NC(=O)C(C(NC(=O)C(NC(=O)C(NC(=O)C(=C)N(C(=O)CCC(NC1=O)C(=O)O)C)C)CC(C)C)C(=O)O)C)CCCN=C(N)N)C=CC(=CC(C)C(CC2=CC=CC=C2)OC)C
InChI: InChI=1S/C49H74N10O12/c1-26(2)23-37-46(66)58-40(48(69)70)30(6)42(62)55-35(17-14-22-52-49(50)51)45(65)54-34(19-18-27(3)24-28(4)38(71-10)25-33-15-12-11-13-16-33)29(5)41(61)56-36(47(67)68)20-21-39(60)59(9)32(8)44(64)53-31(7)43(63)57-37/h11-13,15-16,18-19,24,26,28-31,34-38,40H,8,14,17,20-23,25H2,1-7,9-10H3,(H,53,64)(H,54,65)(H,55,62)(H,56,61)(H,57,63)(H,58,66)(H,67,68)(H,69,70)(H4,50,51,52)/b19-18+,27-24+/t28-,29-,30-,31+,34-,35-,36+,37-,38-,40+/m0/s1

描述信息

A microcystin consisting of D-alanyl, L-leucyl, (3S)-3-methyl-D-beta-aspartyl,L-arginyl, 2S,3S,4E,6E,8S,9S)-3-amino-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimethyl-10-phenyldecanoyl, D-gamma-glutamyl, and 2,3-didehydro-N-methylalanyl residues joined into a 25-membered macrocycle. Produced by the cyanobacterium Microcystis aeruginosa, it is the most studied of the microcystins.
D009676 - Noxae > D002273 - Carcinogens > D052998 - Microcystins
D009676 - Noxae > D011042 - Poisons > D008387 - Marine Toxins
D004791 - Enzyme Inhibitors

同义名列表

1 个代谢物同义名

microcystin-LR



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

10 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Csaba Máthé, Károly Bóka, Zoltán Kónya, Ferenc Erdődi, Gábor Vasas, Csongor Freytag, Tamás Garda. Microcystin-LR, a cyanotoxin, modulates division of higher plant chloroplasts through protein phosphatase inhibition and affects cyanobacterial division. Chemosphere. 2024 Jun; 358(?):142125. doi: 10.1016/j.chemosphere.2024.142125. [PMID: 38670509]
  • Xingde Du, Junjie Liu, Xin Wang, Xinghai Chen, Zhenxing Mao, Fangfang Yu, Pengpeng Wang, Cuiping Wu, Hongxiang Guo, Huizhen Zhang. Environmentally related microcystin-LR-induced ovarian dysfunction via the CCL2-CCR10 axis in mice ameliorated by dietary mulberry. Environmental pollution (Barking, Essex : 1987). 2024 May; 349(?):123929. doi: 10.1016/j.envpol.2024.123929. [PMID: 38582190]
  • Wannes Hugo R Van Hassel, Mohamed F Abdallah, Maria Gracia Guzman Velasquez, Christopher O Miles, Ingunn A Samdal, Julien Masquelier, Andreja Rajkovic. Experimental accumulation and depuration kinetics and natural occurrence of microcystin-LR in basil (Ocimum basilicum L.). Environmental pollution (Barking, Essex : 1987). 2024 Apr; 347(?):123715. doi: 10.1016/j.envpol.2024.123715. [PMID: 38462191]
  • Junfei Liu, Yingbo Dong, Hai Lin. Effects of microcystin-LR on purification efficiency of simulating drinking water source by Hydrocharis dubia (Bl.) backer. Toxicon : official journal of the International Society on Toxinology. 2024 Apr; 241(?):107654. doi: 10.1016/j.toxicon.2024.107654. [PMID: 38368956]
  • Yichao Li, Huici Yang, Bing Fu, Gen Kaneko, Hongyan Li, Jingjing Tian, Guangjun Wang, Mingken Wei, Jun Xie, Ermeng Yu. Integration of Multi-Omics, Histological, and Biochemical Analysis Reveals the Toxic Responses of Nile Tilapia Liver to Chronic Microcystin-LR Exposure. Toxins. 2024 Mar; 16(3):. doi: 10.3390/toxins16030149. [PMID: 38535815]
  • Xiao-Chun Guo, Shao-Yong Lu, Sheng-Nan Zhang, Ping Xie, Guang-Yu Li, Zu-Qin Shi, Yi-Tong Zhou, Yu-Meng Wang. Combined inhibitory effects of microcystin-LR and microcystin-RR on growth and development in zebrafish larvae. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2024 Mar; 277(?):109824. doi: 10.1016/j.cbpc.2023.109824. [PMID: 38154657]
  • Jinlin Jiang, Yue Shi, Feng Tian, Tao Long, Xuzhi Li, Rongrong Ying. Bioaccumulation of Microcystin-LR and Induced Physio-Biochemical Changes in Rice (Oryza sativa L.) at Vegetative Stage under Hydroponic Culture Conditions. Toxins. 2024 02; 16(2):. doi: 10.3390/toxins16020082. [PMID: 38393160]
  • Qing Cao, Bensheng You, Weijing Liu, Bingqing Zhu, Liqiang Xie, Chen Cheng. Effect of different irrigation methods on the toxicity and bioavailability of microcystin-LR to lettuce and carrot. Environmental science and pollution research international. 2023 Oct; 30(47):104554-104562. doi: 10.1007/s11356-023-29800-2. [PMID: 37704817]
  • Wang Lin, Kang Ouyang, Ya He, Hui Yang, Yu Kuang, Dapeng Li, Li Li. Combined effects of microcystin-LR and rice straw-derived biochar on the hepatic antioxidant capacity of zebrafish: Insights from LC-MS/MS-based metabolomics analysis. The Science of the total environment. 2023 Sep; 904(?):166830. doi: 10.1016/j.scitotenv.2023.166830. [PMID: 37673272]
  • Zhengqiang Hu, Guanmin Meng, Lejun Zhang, Meng Zhang, Huashun Cui, Huifang Tang. Protective effect of Huanglianjiedu Decoction on microcystin-LR induced nerve injury. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2023 Jul; ?(?):109698. doi: 10.1016/j.cbpc.2023.109698. [PMID: 37442312]
  • Shota Takumi, Kairi Hashimoto, Masaru Tomioka, Mina Sato, Weijie He, Yumiko Komatsu, Shunji Aoki, Ryuji Ikeda, Kazuhiro Shiozaki, Tatsuhiko Furukawa, Masaharu Komatsu. Acteoside from Conandron ramondioides Reduces Microcystin-LR Cytotoxicity by Inhibiting Intracellular Uptake Mediated by OATP1B3. Planta medica. 2023 Jan; ?(?):. doi: 10.1055/a-1978-8768. [PMID: 36626925]
  • Xiang Liu, Jin-Cheng Ye, Fen Li, Rong-Jun Gao, Xiao-Xiao Wang, Ji-Liang Cheng, Bai-Lin Liu, Lei Xiang, Yan-Wen Li, Quan-Ying Cai, Hai-Ming Zhao, Ce-Hui Mo, Qing X Li. Revealing microcystin-LR ecotoxicity to earthworm (Eisenia fetida) at the intestinal cell level. Chemosphere. 2023 Jan; 311(Pt 1):137046. doi: 10.1016/j.chemosphere.2022.137046. [PMID: 36419272]
  • Hanyu Chu, Can Du, Yue Yang, Xiangling Feng, Lemei Zhu, Jihua Chen, Fei Yang. MC-LR Aggravates Liver Lipid Metabolism Disorders in Obese Mice Fed a High-Fat Diet via PI3K/AKT/mTOR/SREBP1 Signaling Pathway. Toxins. 2022 11; 14(12):. doi: 10.3390/toxins14120833. [PMID: 36548730]
  • Dimitris Pappas, Eleni Giannoutsou, Emmanuel Panteris, Spyros Gkelis, Ioannis-Dimosthenis S Adamakis. Microcystin-LR and cyanobacterial extracts alter the distribution of cell wall matrix components in rice root cells. Plant physiology and biochemistry : PPB. 2022 Nov; 191(?):78-88. doi: 10.1016/j.plaphy.2022.09.020. [PMID: 36195035]
  • Chun Pan, Haixiang Qin, Haibo Jin, Wenyuan Chen, Hongqian Guo, Xiaodong Han. Environmental exposure to microcystin-LR increases the risks of urinary bladder proliferation and carcinogenesis: Evidence from case control, animal, and in vitro studies. Toxicology. 2022 10; 480(?):153326. doi: 10.1016/j.tox.2022.153326. [PMID: 36115647]
  • Jing Dong, Dujuan Dai, Yue Yang, Feihu Wang, Xuejun Li, Jie Yuan, Yuhuan Chen, Yunni Gao, Man Zhang, Xiaofei Gao, Mei Li, Jingxiao Zhang. Responses of submerged macrophyte Ceratophyllum demersum to the gradient concentrations of microcystin-LR (MC-LR). Environmental science and pollution research international. 2022 Oct; 29(47):71257-71269. doi: 10.1007/s11356-022-20917-4. [PMID: 35596866]
  • Meng Tian, Jihua Wang, Chonghui Li, Zhenxing Wang, Guofeng Liu, Enguang Lv, Xiaofei Zhao, Zhen Li, Dongyan Cao, Huilan Liu, Chao Zhang, Shicai Xu, Baoyuan Man. Qualitative and quantitative detection of microcystin-LR based on SERS-FET dual-mode biosensor. Biosensors & bioelectronics. 2022 Sep; 212(?):114434. doi: 10.1016/j.bios.2022.114434. [PMID: 35671700]
  • Can Du, Shuilin Zheng, Yue Yang, Xiangling Feng, Jihua Chen, Yan Tang, Hui Wang, Fei Yang. Chronic exposure to low concentration of MC-LR caused hepatic lipid metabolism disorder. Ecotoxicology and environmental safety. 2022 Jul; 239(?):113649. doi: 10.1016/j.ecoenv.2022.113649. [PMID: 35605325]
  • Leticia Diez-Quijada, María Puerto, Daniel Gutiérrez-Praena, Maria V Turkina, Alexandre Campos, Vitor Vasconcelos, Ana M Cameán, Ángeles Jos. In Vitro Toxicity Evaluation of Cyanotoxins Cylindrospermopsin and Microcystin-LR on Human Kidney HEK293 Cells. Toxins. 2022 06; 14(7):. doi: 10.3390/toxins14070429. [PMID: 35878167]
  • Shenghe Cai, Yilin Shu, Cuicui Tian, Chunbo Wang, Tao Fang, Bangding Xiao, Xingqiang Wu. Effects of chronic exposure to microcystin-LR on life-history traits, intestinal microbiota and transcriptomic responses in Chironomus pallidivittatus. The Science of the total environment. 2022 Jun; 823(?):153624. doi: 10.1016/j.scitotenv.2022.153624. [PMID: 35124034]
  • Yafei Duan, Shimin Zeng, Zijun Lu, Xueming Dan, Zequan Mo, Yifu Xing, Jiasong Zhang, Yanwei Li. Responses of lipid metabolism and lipidomics in the hepatopancreas of Pacific white shrimp Litopenaeus vannamei to microcystin-LR exposure. The Science of the total environment. 2022 May; 820(?):153245. doi: 10.1016/j.scitotenv.2022.153245. [PMID: 35065121]
  • Cheng Chi, Sib Sankar Giri, Xia Wei Yu, Yuan Liu, Ke Ke Chen, Wen Bin Liu, Ding Dong Zhang, Guang Zhen Jiang, Xiang Fei Li, Xin Gao, Bin Lin Chen, Se Chang Park. Lipid metabolism, immune and apoptosis transcriptomic responses of the hepatopancreas of Chinese mitten crab to the exposure to microcystin-LR. Ecotoxicology and environmental safety. 2022 May; 236(?):113439. doi: 10.1016/j.ecoenv.2022.113439. [PMID: 35367891]
  • Qi Li, Xueping Tian, Peng Gu, Guili Yang, Hong Deng, Jibiao Zhang, Zheng Zheng. Transcriptomic analysis reveals phytohormone and photosynthetic molecular mechanisms of a submerged macrophyte in response to microcystin-LR stress. Aquatic toxicology (Amsterdam, Netherlands). 2022 Apr; 245(?):106119. doi: 10.1016/j.aquatox.2022.106119. [PMID: 35220087]
  • Mousa O Germoush, Maged M A Fouda, Mohamed Kamel, Mohamed M Abdel-Daim. Spirulina platensis protects against microcystin-LR-induced toxicity in rats. Environmental science and pollution research international. 2022 Feb; 29(8):11320-11331. doi: 10.1007/s11356-021-16481-y. [PMID: 34533748]
  • Jun He, Yilin Shu, Yue Dai, Yuxin Gao, Shuyi Liu, Wenchao Wang, Huiling Jiang, Huijuan Zhang, Pei Hong, Hailong Wu. Microcystin-leucine arginine exposure induced intestinal lipid accumulation and MC-LR efflux disorder in Lithobates catesbeianus tadpoles. Toxicology. 2022 01; 465(?):153058. doi: 10.1016/j.tox.2021.153058. [PMID: 34863901]
  • Qing Cao, Bensheng You, Weijing Liu, Liqiang Xie, Weili Jiang, Chen Cheng. Using soil amendments to reduce microcystin-LR bioaccumulation in lettuce. Environmental pollution (Barking, Essex : 1987). 2022 Jan; 292(Pt A):118354. doi: 10.1016/j.envpol.2021.118354. [PMID: 34648839]
  • Wang Lin, Honghui Guo, Liping Yang, Yu Kuang, Dapeng Li, Pinhong Yang, Li Li. Alleviation of microcystin-LR-induced hepatic lipidosis and apoptosis in zebrafish by use of rice straw-derived biochar. Ecotoxicology and environmental safety. 2022 Jan; 229(?):113054. doi: 10.1016/j.ecoenv.2021.113054. [PMID: 34894426]
  • Leila Ait Abderrahim, Khaled Taibi, Mohamed Boussaid, Baker Al-Shara, Nawel Ait Abderrahim, Sabrina Ait Abderrahim. Allium sativum mitigates oxidative damages induced by Microcystin-LR in heart and liver tissues of mice. Toxicon : official journal of the International Society on Toxinology. 2021 Sep; 200(?):30-37. doi: 10.1016/j.toxicon.2021.06.018. [PMID: 34217748]
  • Csongor Freytag, Csaba Máthé, Gábor Rigó, Tomasz Nodzyński, Zoltán Kónya, Ferenc Erdődi, Ágnes Cséplő, Erik Pózer, László Szabados, Adrienn Kelemen, Gábor Vasas, Tamás Garda. Microcystin-LR, a cyanobacterial toxin affects root development by changing levels of PIN proteins and auxin response in Arabidopsis roots. Chemosphere. 2021 Aug; 276(?):130183. doi: 10.1016/j.chemosphere.2021.130183. [PMID: 34088085]
  • Cheng Chi, Xia-Wei Yu, Cai-Yan Zhang, Jia-Dai Liu, Ming-Wen Ye, Ding-Dong Zhang, Wen-Bin Liu. Acute exposure to microcystin-LR induces hepatopancreas toxicity in the Chinese mitten crab (Eriocheir sinensis). Archives of toxicology. 2021 07; 95(7):2551-2570. doi: 10.1007/s00204-021-03061-9. [PMID: 33977345]
  • H Zaidi, A Amrani, F Sedrati, H Maaref, F Leghrib, M Benamara, H Amara, Zhi Wang, H Nasri. Histological and chemical damage induced by microcystin-LR and microcystin-RR on land snail Helix aspersa tissues after acute exposure. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2021 Jul; 245(?):109031. doi: 10.1016/j.cbpc.2021.109031. [PMID: 33737222]
  • Shihui Chen, Jinlin Jiang, Tao Long, Xingcheng Zhu, Huanchao Zhang, Shaopo Deng, Renbin Liu. Oxidative stress induced in rice suspension cells exposed to microcystin-LR at environmentally relevant concentrations. Environmental science and pollution research international. 2021 Jul; 28(28):38393-38405. doi: 10.1007/s11356-021-13353-3. [PMID: 33730331]
  • Molly C Mills, Morgan V Evans, Seungjun Lee, Thomas Knobloch, Christopher Weghorst, Jiyoung Lee. Acute cyanotoxin poisoning reveals a marginal effect on mouse gut microbiome composition but indicates metabolic shifts related to liver and gut inflammation. Ecotoxicology and environmental safety. 2021 Jun; 215(?):112126. doi: 10.1016/j.ecoenv.2021.112126. [PMID: 33721663]
  • Tarana Arman, Katherine D Lynch, Michael Goedken, John D Clarke. Sub-chronic microcystin-LR renal toxicity in rats fed a high fat/high cholesterol diet. Chemosphere. 2021 Apr; 269(?):128773. doi: 10.1016/j.chemosphere.2020.128773. [PMID: 33143886]
  • Hui Zeng, Yao Tan, Lingqiao Wang, Menglong Xiang, Ziyuan Zhou, Ji-An Chen, Jia Wang, Renping Zhang, Yingqiao Tian, Jiaohua Luo, Yujing Huang, Chen Lv, Weiqun Shu, Zhiqun Qiu. Association of serum microcystin levels with neurobehavior of school-age children in rural area of Southwest China: A cross-sectional study. Ecotoxicology and environmental safety. 2021 Apr; 212(?):111990. doi: 10.1016/j.ecoenv.2021.111990. [PMID: 33524912]
  • Małgorzata Kucała, Michał Saładyga, Ariel Kaminski. Phytoremediation of CYN, MC-LR and ANTX-a from Water by the Submerged Macrophyte Lemna trisulca. Cells. 2021 03; 10(3):. doi: 10.3390/cells10030699. [PMID: 33801135]
  • Chongxin Xu, Dan He, Yao Zu, Sujuan Hong, Jia Hao, Jianhong Li. Microcystin-LR heterologous genetically engineered antibody recombinant and its binding activity improvement and application in immunoassay. Journal of hazardous materials. 2021 03; 406(?):124596. doi: 10.1016/j.jhazmat.2020.124596. [PMID: 33307449]
  • Babita Deep Srivastava, Manish Srivastava, Sunil Kumar Srivastav, Makoto Urata, Nobuo Suzuki, Ajai Kumar Srivastav. Ameliorative effects of jamun seed and orange peel extracts on microcystin LR induced alterations in calcitonin cells and parathyroid gland of rats. Microscopy research and technique. 2021 Mar; 84(3):571-578. doi: 10.1002/jemt.23615. [PMID: 33135864]
  • Gui-Li Yang, Meng-Jun Huang, Ai-Juan Tan, Shi-Ming Lv. Joint effects of naphthalene and microcystin-LR on physiological responses and toxin bioaccumulation of Landoltia punctata. Aquatic toxicology (Amsterdam, Netherlands). 2021 Feb; 231(?):105710. doi: 10.1016/j.aquatox.2020.105710. [PMID: 33338701]
  • Neil Chernoff, Donna Hill, Johnsie Lang, Judith Schmid, Amy Farthing, Hwa Huang. Dose-Response Study of Microcystin Congeners MCLA, MCLR, MCLY, MCRR, and MCYR Administered Orally to Mice. Toxins. 2021 01; 13(2):. doi: 10.3390/toxins13020086. [PMID: 33498948]
  • Pratik Kumar, Maximiliano Cledon, Satinder Kaur Brar. A low-cost graphitized sand filter to deliver MC-LR-free potable water: Water treatment plants and household perspective. The Science of the total environment. 2020 Dec; 747(?):141135. doi: 10.1016/j.scitotenv.2020.141135. [PMID: 32795791]
  • Li He, Lin Liu, Changgao Lin, Jiming Ruan, Ximei Liang, Ying Zhou, Lili Wei. Effects of MC-LR on histological structure and cell apoptosis in the kidney of grass carp (Ctenopharyngodon idella). Fish physiology and biochemistry. 2020 Dec; 46(6):2005-2014. doi: 10.1007/s10695-020-00833-5. [PMID: 32712898]
  • Massimo Picardo, Josep Sanchís, Oscar Núñez, Marinella Farré. Suspect screening of natural toxins in surface and drinking water by high performance liquid chromatography and high-resolution mass spectrometry. Chemosphere. 2020 Dec; 261(?):127888. doi: 10.1016/j.chemosphere.2020.127888. [PMID: 33113669]
  • Qing Cao, Weijing Liu, Yurong Gu, Liqiang Xie, Weili Jiang, Yan Gao, Liuyan Yang. Synergetic enhancement toxicity of copper, cadmium and microcystin-LR to the Ceratophyllum demersum L. Toxicon : official journal of the International Society on Toxinology. 2020 Oct; 186(?):151-159. doi: 10.1016/j.toxicon.2020.08.008. [PMID: 32798503]
  • Daniela Sedan, Luciano Malaissi, Cristian Adrián Vaccarini, Ezequiel Ventosi, Martín Laguens, Lorena Rosso, Leda Giannuzzi, Darío Andrinolo. [D-Leu1]MC-LR Has Lower PP1 Inhibitory Capability and Greater Toxic Potency than MC-LR in Animal and Plant Tissues. Toxins. 2020 10; 12(10):. doi: 10.3390/toxins12100632. [PMID: 33019556]
  • Luciano Malaissi, Cristian Adrián Vaccarini, Marcelo Paulo Hernández, Marcela Ruscitti, Cecilia Arango, Federico Busquets, Ana María Arambarri, Leda Giannuzzi, Darío Andrinolo, Daniela Sedan. [D-Leu1]MC-LR and MC-LR: A Small-Large Difference: Significantly Different Effects on Phaseolus vulgaris L. (Fabaceae) Growth and Phototropic Response after Single Contact during Imbibition with Each of These Microcystin Variants. Toxins. 2020 09; 12(9):. doi: 10.3390/toxins12090585. [PMID: 32932764]
  • D Pappas, S Gkelis, E Panteris. The effects of microcystin-LR in Oryza sativa root cells: F-actin as a new target of cyanobacterial toxicity. Plant biology (Stuttgart, Germany). 2020 Sep; 22(5):839-849. doi: 10.1111/plb.13120. [PMID: 32268449]
  • Guoyuan Chen, Zhihong Zheng, Mingxian Bai, Qingsong Li. Chronic effects of microcystin-LR at environmental relevant concentrations on photosynthesis of Typha angustifolia Linn. Ecotoxicology (London, England). 2020 Jul; 29(5):514-523. doi: 10.1007/s10646-020-02196-2. [PMID: 32277321]
  • Yu Chen, Kun Chen, Yuan Zhou, Xingjia Li, Xiaodong Mao, Xiao Wei, Yijiao Xu, Wanwei Yang, Guofang Chen, Chao Liu. Microcystin-LR impairs glucose metabolism in pancreatic β cells in vivo and in vitro. Toxicology letters. 2020 Jun; 326(?):106-113. doi: 10.1016/j.toxlet.2020.03.003. [PMID: 32142839]
  • Qi Li, Peng Gu, Chen Zhang, Xin Luo, Hao Zhang, Jibiao Zhang, Zheng Zheng. Combined toxic effects of anatoxin-a and microcystin-LR on submerged macrophytes and biofilms. Journal of hazardous materials. 2020 05; 389(?):122053. doi: 10.1016/j.jhazmat.2020.122053. [PMID: 31978825]
  • Lingkai Wang, Wang Lin, Qingji Zha, Honghui Guo, Dandan Zhang, Liping Yang, Li Li, Dapeng Li, Rong Tang. Persistent Exposure to Environmental Levels of Microcystin-LR Disturbs Cortisol Production via Hypothalamic-Pituitary-Interrenal (HPI) Axis and Subsequently Liver Glucose Metabolism in Adult Male Zebrafish (Danio rerio). Toxins. 2020 04; 12(5):. doi: 10.3390/toxins12050282. [PMID: 32353954]
  • Wanda Czyżewska, Marlena Piontek, Katarzyna Łuszczyńska. The Occurrence of Potential Harmful Cyanobacteria and Cyanotoxins in the Obrzyca River (Poland), a Source of Drinking Water. Toxins. 2020 04; 12(5):. doi: 10.3390/toxins12050284. [PMID: 32354080]
  • Zhen-Lin Xu, Song-Ling Ye, Lin Luo, Xiude Hua, Jing-Xian Lai, Xiang-Ping Cai, Qing-Wen Liang, Hong-Tao Lei, Yuan-Ming Sun, Yi-Ping Chen, Xing Shen. Fluorescent enzyme-linked immunoassay based on silane-doped carbon dots for sensitive detection of microcystin-LR in water and crucian samples. The Science of the total environment. 2020 Mar; 708(?):134614. doi: 10.1016/j.scitotenv.2019.134614. [PMID: 31806319]
  • Yunni Gao, Jing Lu, Philip T Orr, Ann Chuang, Hannah M Franklin, Michele A Burford. Enhanced resistance of co-existing toxigenic and non-toxigenic Microcystis aeruginosa to pyrogallol compared with monostrains. Toxicon : official journal of the International Society on Toxinology. 2020 Mar; 176(?):47-54. doi: 10.1016/j.toxicon.2020.01.013. [PMID: 32103795]
  • Dandan Zhang, Wang Lin, Yinjie Liu, Honghui Guo, Lingkai Wang, Liping Yang, Li Li, Dapeng Li, Rong Tang. Chronic Microcystin-LR Exposure Induces Abnormal Lipid Metabolism via Endoplasmic Reticulum Stress in Male Zebrafish. Toxins. 2020 02; 12(2):. doi: 10.3390/toxins12020107. [PMID: 32046144]
  • Wang Lin, Honghui Guo, Lingkai Wang, Dandan Zhang, Xueyang Wu, Li Li, Yuming Qiu, Liping Yang, Dapeng Li, Rong Tang. Waterborne microcystin-LR exposure induced chronic inflammatory response via MyD88-dependent toll-like receptor signaling pathway in male zebrafish. The Science of the total environment. 2020 Feb; 702(?):134969. doi: 10.1016/j.scitotenv.2019.134969. [PMID: 31710851]
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