Microcystin LR (BioDeep_00000002207)
Secondary id: BioDeep_00001867751
Marine Natural Products
代谢物信息卡片
Cyanoginosin-LR;MC-LR;Toxin T 17 (Microcystis aeruginosa)
化学式: C49H74N10O12 (994.5487)
中文名称: 微囊藻毒素Microcystin-LR
谱图信息:
最多检出来源 not specific(not specific) 0%
分子结构信息
SMILES: C=C1C(=O)NC(C)C(=O)NC(CC(C)C)C(=O)NC(C(=O)O)C(C)C(=O)NC(CCCNC(=N)N)C(=O)NC(C=CC(C)=CC(C)C(Cc2ccccc2)OC)C(C)C(=O)NC(C(=O)O)CCC(=O)N1C
InChI: InChI=1S/C49H74N10O12/c1-26(2)23-37-46(66)58-40(48(69)70)30(6)42(62)55-35(17-14-22-52-49(50)51)45(65)54-34(19-18-27(3)24-28(4)38(71-10)25-33-15-12-11-13-16-33)29(5)41(61)56-36(47(67)68)20-21-39(60)59(9)32(8)44(64)53-31(7)43(63)57-37/h11-13,15-16,18-19,24,26,28-31,34-38,40H,8,14,17,20-23,25H2,1-7,9-10H3,(H,53,64)(H,54,65)(H,55,62)(H,56,61)(H,57,63)(H,58,66)(H,67,68)(H,69,70)(H4,50,51,52)/b19-18+,27-24+/t28-,29-,30-,31+,34-,35-,36+,37-,38-,40+/m0/s1
描述信息
CONFIDENCE standard compound; UCHEM_ID 2992; NaToxAq - Natural Toxins and Drinking Water Quality - From Source to Tap (https://natoxaq.ku.dk)
D009676 - Noxae > D002273 - Carcinogens > D052998 - Microcystins
D009676 - Noxae > D011042 - Poisons > D008387 - Marine Toxins
CONFIDENCE standard compound; EAWAG_UCHEM_ID 2992
D004791 - Enzyme Inhibitors
同义名列表
数据库引用编号
40 个数据库交叉引用编号
- ChEBI: CHEBI:6925
- KEGG: C05371
- PubChem: 3595220
- PubChem: 445434
- Metlin: METLIN66313
- ChEMBL: CHEMBL444092
- CAS: 101043-37-2
- MoNA: EQ299204
- MoNA: EA299208
- MoNA: EQ299255
- MoNA: EA299201
- MoNA: EQ299209
- MoNA: EA299211
- MoNA: EQ299253
- MoNA: EQ299208
- MoNA: EA299202
- MoNA: EQ299254
- MoNA: EA299207
- MoNA: EQ299256
- MoNA: EA299212
- MoNA: EQ299205
- MoNA: EQ299252
- MoNA: EA299214
- MoNA: EQ299207
- MoNA: EQ299202
- MoNA: EA299206
- MoNA: EQ299251
- MoNA: EA299204
- MoNA: EA299209
- MoNA: EA299205
- MoNA: EQ299203
- MoNA: EQ299206
- MoNA: EA299213
- MoNA: EA299210
- MoNA: EA299203
- MoNA: EQ299201
- PMhub: MS000002124
- PubChem: 7745
- 3DMET: B01848
- KNApSAcK: 6925
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
5 个相关的物种来源信息
- 1190 - Fischerella: 10.1016/J.TOXICON.2017.10.021
- 1126 - Microcystis aeruginosa:
- 44822 - Microcystis viridis:
- 70799 - Nodularia spumigena: 10.1016/S0040-4039(00)61500-9
- 316894 - Romanoa: 10.1128/AEM.70.2.686-692.2004
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Csaba Máthé, Károly Bóka, Zoltán Kónya, Ferenc Erdődi, Gábor Vasas, Csongor Freytag, Tamás Garda. Microcystin-LR, a cyanotoxin, modulates division of higher plant chloroplasts through protein phosphatase inhibition and affects cyanobacterial division.
Chemosphere.
2024 Jun; 358(?):142125. doi:
10.1016/j.chemosphere.2024.142125. [PMID: 38670509] - Xingde Du, Junjie Liu, Xin Wang, Xinghai Chen, Zhenxing Mao, Fangfang Yu, Pengpeng Wang, Cuiping Wu, Hongxiang Guo, Huizhen Zhang. Environmentally related microcystin-LR-induced ovarian dysfunction via the CCL2-CCR10 axis in mice ameliorated by dietary mulberry.
Environmental pollution (Barking, Essex : 1987).
2024 May; 349(?):123929. doi:
10.1016/j.envpol.2024.123929. [PMID: 38582190] - Wannes Hugo R Van Hassel, Mohamed F Abdallah, Maria Gracia Guzman Velasquez, Christopher O Miles, Ingunn A Samdal, Julien Masquelier, Andreja Rajkovic. Experimental accumulation and depuration kinetics and natural occurrence of microcystin-LR in basil (Ocimum basilicum L.).
Environmental pollution (Barking, Essex : 1987).
2024 Apr; 347(?):123715. doi:
10.1016/j.envpol.2024.123715. [PMID: 38462191] - Junfei Liu, Yingbo Dong, Hai Lin. Effects of microcystin-LR on purification efficiency of simulating drinking water source by Hydrocharis dubia (Bl.) backer.
Toxicon : official journal of the International Society on Toxinology.
2024 Apr; 241(?):107654. doi:
10.1016/j.toxicon.2024.107654. [PMID: 38368956] - Yichao Li, Huici Yang, Bing Fu, Gen Kaneko, Hongyan Li, Jingjing Tian, Guangjun Wang, Mingken Wei, Jun Xie, Ermeng Yu. Integration of Multi-Omics, Histological, and Biochemical Analysis Reveals the Toxic Responses of Nile Tilapia Liver to Chronic Microcystin-LR Exposure.
Toxins.
2024 Mar; 16(3):. doi:
10.3390/toxins16030149. [PMID: 38535815] - Xiao-Chun Guo, Shao-Yong Lu, Sheng-Nan Zhang, Ping Xie, Guang-Yu Li, Zu-Qin Shi, Yi-Tong Zhou, Yu-Meng Wang. Combined inhibitory effects of microcystin-LR and microcystin-RR on growth and development in zebrafish larvae.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.
2024 Mar; 277(?):109824. doi:
10.1016/j.cbpc.2023.109824. [PMID: 38154657] - Jinlin Jiang, Yue Shi, Feng Tian, Tao Long, Xuzhi Li, Rongrong Ying. Bioaccumulation of Microcystin-LR and Induced Physio-Biochemical Changes in Rice (Oryza sativa L.) at Vegetative Stage under Hydroponic Culture Conditions.
Toxins.
2024 02; 16(2):. doi:
10.3390/toxins16020082. [PMID: 38393160] - Qing Cao, Bensheng You, Weijing Liu, Bingqing Zhu, Liqiang Xie, Chen Cheng. Effect of different irrigation methods on the toxicity and bioavailability of microcystin-LR to lettuce and carrot.
Environmental science and pollution research international.
2023 Oct; 30(47):104554-104562. doi:
10.1007/s11356-023-29800-2. [PMID: 37704817] - Wang Lin, Kang Ouyang, Ya He, Hui Yang, Yu Kuang, Dapeng Li, Li Li. Combined effects of microcystin-LR and rice straw-derived biochar on the hepatic antioxidant capacity of zebrafish: Insights from LC-MS/MS-based metabolomics analysis.
The Science of the total environment.
2023 Sep; 904(?):166830. doi:
10.1016/j.scitotenv.2023.166830. [PMID: 37673272] - Zhengqiang Hu, Guanmin Meng, Lejun Zhang, Meng Zhang, Huashun Cui, Huifang Tang. Protective effect of Huanglianjiedu Decoction on microcystin-LR induced nerve injury.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.
2023 Jul; ?(?):109698. doi:
10.1016/j.cbpc.2023.109698. [PMID: 37442312] - Shota Takumi, Kairi Hashimoto, Masaru Tomioka, Mina Sato, Weijie He, Yumiko Komatsu, Shunji Aoki, Ryuji Ikeda, Kazuhiro Shiozaki, Tatsuhiko Furukawa, Masaharu Komatsu. Acteoside from Conandron ramondioides Reduces Microcystin-LR Cytotoxicity by Inhibiting Intracellular Uptake Mediated by OATP1B3.
Planta medica.
2023 Jan; ?(?):. doi:
10.1055/a-1978-8768. [PMID: 36626925] - Xiang Liu, Jin-Cheng Ye, Fen Li, Rong-Jun Gao, Xiao-Xiao Wang, Ji-Liang Cheng, Bai-Lin Liu, Lei Xiang, Yan-Wen Li, Quan-Ying Cai, Hai-Ming Zhao, Ce-Hui Mo, Qing X Li. Revealing microcystin-LR ecotoxicity to earthworm (Eisenia fetida) at the intestinal cell level.
Chemosphere.
2023 Jan; 311(Pt 1):137046. doi:
10.1016/j.chemosphere.2022.137046. [PMID: 36419272] - Hanyu Chu, Can Du, Yue Yang, Xiangling Feng, Lemei Zhu, Jihua Chen, Fei Yang. MC-LR Aggravates Liver Lipid Metabolism Disorders in Obese Mice Fed a High-Fat Diet via PI3K/AKT/mTOR/SREBP1 Signaling Pathway.
Toxins.
2022 11; 14(12):. doi:
10.3390/toxins14120833. [PMID: 36548730] - Dimitris Pappas, Eleni Giannoutsou, Emmanuel Panteris, Spyros Gkelis, Ioannis-Dimosthenis S Adamakis. Microcystin-LR and cyanobacterial extracts alter the distribution of cell wall matrix components in rice root cells.
Plant physiology and biochemistry : PPB.
2022 Nov; 191(?):78-88. doi:
10.1016/j.plaphy.2022.09.020. [PMID: 36195035] - Chun Pan, Haixiang Qin, Haibo Jin, Wenyuan Chen, Hongqian Guo, Xiaodong Han. Environmental exposure to microcystin-LR increases the risks of urinary bladder proliferation and carcinogenesis: Evidence from case control, animal, and in vitro studies.
Toxicology.
2022 10; 480(?):153326. doi:
10.1016/j.tox.2022.153326. [PMID: 36115647] - Jing Dong, Dujuan Dai, Yue Yang, Feihu Wang, Xuejun Li, Jie Yuan, Yuhuan Chen, Yunni Gao, Man Zhang, Xiaofei Gao, Mei Li, Jingxiao Zhang. Responses of submerged macrophyte Ceratophyllum demersum to the gradient concentrations of microcystin-LR (MC-LR).
Environmental science and pollution research international.
2022 Oct; 29(47):71257-71269. doi:
10.1007/s11356-022-20917-4. [PMID: 35596866] - Meng Tian, Jihua Wang, Chonghui Li, Zhenxing Wang, Guofeng Liu, Enguang Lv, Xiaofei Zhao, Zhen Li, Dongyan Cao, Huilan Liu, Chao Zhang, Shicai Xu, Baoyuan Man. Qualitative and quantitative detection of microcystin-LR based on SERS-FET dual-mode biosensor.
Biosensors & bioelectronics.
2022 Sep; 212(?):114434. doi:
10.1016/j.bios.2022.114434. [PMID: 35671700] - Can Du, Shuilin Zheng, Yue Yang, Xiangling Feng, Jihua Chen, Yan Tang, Hui Wang, Fei Yang. Chronic exposure to low concentration of MC-LR caused hepatic lipid metabolism disorder.
Ecotoxicology and environmental safety.
2022 Jul; 239(?):113649. doi:
10.1016/j.ecoenv.2022.113649. [PMID: 35605325] - Leticia Diez-Quijada, María Puerto, Daniel Gutiérrez-Praena, Maria V Turkina, Alexandre Campos, Vitor Vasconcelos, Ana M Cameán, Ángeles Jos. In Vitro Toxicity Evaluation of Cyanotoxins Cylindrospermopsin and Microcystin-LR on Human Kidney HEK293 Cells.
Toxins.
2022 06; 14(7):. doi:
10.3390/toxins14070429. [PMID: 35878167] - Shenghe Cai, Yilin Shu, Cuicui Tian, Chunbo Wang, Tao Fang, Bangding Xiao, Xingqiang Wu. Effects of chronic exposure to microcystin-LR on life-history traits, intestinal microbiota and transcriptomic responses in Chironomus pallidivittatus.
The Science of the total environment.
2022 Jun; 823(?):153624. doi:
10.1016/j.scitotenv.2022.153624. [PMID: 35124034] - Yafei Duan, Shimin Zeng, Zijun Lu, Xueming Dan, Zequan Mo, Yifu Xing, Jiasong Zhang, Yanwei Li. Responses of lipid metabolism and lipidomics in the hepatopancreas of Pacific white shrimp Litopenaeus vannamei to microcystin-LR exposure.
The Science of the total environment.
2022 May; 820(?):153245. doi:
10.1016/j.scitotenv.2022.153245. [PMID: 35065121] - Cheng Chi, Sib Sankar Giri, Xia Wei Yu, Yuan Liu, Ke Ke Chen, Wen Bin Liu, Ding Dong Zhang, Guang Zhen Jiang, Xiang Fei Li, Xin Gao, Bin Lin Chen, Se Chang Park. Lipid metabolism, immune and apoptosis transcriptomic responses of the hepatopancreas of Chinese mitten crab to the exposure to microcystin-LR.
Ecotoxicology and environmental safety.
2022 May; 236(?):113439. doi:
10.1016/j.ecoenv.2022.113439. [PMID: 35367891] - Qi Li, Xueping Tian, Peng Gu, Guili Yang, Hong Deng, Jibiao Zhang, Zheng Zheng. Transcriptomic analysis reveals phytohormone and photosynthetic molecular mechanisms of a submerged macrophyte in response to microcystin-LR stress.
Aquatic toxicology (Amsterdam, Netherlands).
2022 Apr; 245(?):106119. doi:
10.1016/j.aquatox.2022.106119. [PMID: 35220087] - Mousa O Germoush, Maged M A Fouda, Mohamed Kamel, Mohamed M Abdel-Daim. Spirulina platensis protects against microcystin-LR-induced toxicity in rats.
Environmental science and pollution research international.
2022 Feb; 29(8):11320-11331. doi:
10.1007/s11356-021-16481-y. [PMID: 34533748] - Jun He, Yilin Shu, Yue Dai, Yuxin Gao, Shuyi Liu, Wenchao Wang, Huiling Jiang, Huijuan Zhang, Pei Hong, Hailong Wu. Microcystin-leucine arginine exposure induced intestinal lipid accumulation and MC-LR efflux disorder in Lithobates catesbeianus tadpoles.
Toxicology.
2022 01; 465(?):153058. doi:
10.1016/j.tox.2021.153058. [PMID: 34863901] - Qing Cao, Bensheng You, Weijing Liu, Liqiang Xie, Weili Jiang, Chen Cheng. Using soil amendments to reduce microcystin-LR bioaccumulation in lettuce.
Environmental pollution (Barking, Essex : 1987).
2022 Jan; 292(Pt A):118354. doi:
10.1016/j.envpol.2021.118354. [PMID: 34648839] - Wang Lin, Honghui Guo, Liping Yang, Yu Kuang, Dapeng Li, Pinhong Yang, Li Li. Alleviation of microcystin-LR-induced hepatic lipidosis and apoptosis in zebrafish by use of rice straw-derived biochar.
Ecotoxicology and environmental safety.
2022 Jan; 229(?):113054. doi:
10.1016/j.ecoenv.2021.113054. [PMID: 34894426] - Leila Ait Abderrahim, Khaled Taibi, Mohamed Boussaid, Baker Al-Shara, Nawel Ait Abderrahim, Sabrina Ait Abderrahim. Allium sativum mitigates oxidative damages induced by Microcystin-LR in heart and liver tissues of mice.
Toxicon : official journal of the International Society on Toxinology.
2021 Sep; 200(?):30-37. doi:
10.1016/j.toxicon.2021.06.018. [PMID: 34217748] - Csongor Freytag, Csaba Máthé, Gábor Rigó, Tomasz Nodzyński, Zoltán Kónya, Ferenc Erdődi, Ágnes Cséplő, Erik Pózer, László Szabados, Adrienn Kelemen, Gábor Vasas, Tamás Garda. Microcystin-LR, a cyanobacterial toxin affects root development by changing levels of PIN proteins and auxin response in Arabidopsis roots.
Chemosphere.
2021 Aug; 276(?):130183. doi:
10.1016/j.chemosphere.2021.130183. [PMID: 34088085] - Cheng Chi, Xia-Wei Yu, Cai-Yan Zhang, Jia-Dai Liu, Ming-Wen Ye, Ding-Dong Zhang, Wen-Bin Liu. Acute exposure to microcystin-LR induces hepatopancreas toxicity in the Chinese mitten crab (Eriocheir sinensis).
Archives of toxicology.
2021 07; 95(7):2551-2570. doi:
10.1007/s00204-021-03061-9. [PMID: 33977345] - H Zaidi, A Amrani, F Sedrati, H Maaref, F Leghrib, M Benamara, H Amara, Zhi Wang, H Nasri. Histological and chemical damage induced by microcystin-LR and microcystin-RR on land snail Helix aspersa tissues after acute exposure.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.
2021 Jul; 245(?):109031. doi:
10.1016/j.cbpc.2021.109031. [PMID: 33737222] - Shihui Chen, Jinlin Jiang, Tao Long, Xingcheng Zhu, Huanchao Zhang, Shaopo Deng, Renbin Liu. Oxidative stress induced in rice suspension cells exposed to microcystin-LR at environmentally relevant concentrations.
Environmental science and pollution research international.
2021 Jul; 28(28):38393-38405. doi:
10.1007/s11356-021-13353-3. [PMID: 33730331] - Molly C Mills, Morgan V Evans, Seungjun Lee, Thomas Knobloch, Christopher Weghorst, Jiyoung Lee. Acute cyanotoxin poisoning reveals a marginal effect on mouse gut microbiome composition but indicates metabolic shifts related to liver and gut inflammation.
Ecotoxicology and environmental safety.
2021 Jun; 215(?):112126. doi:
10.1016/j.ecoenv.2021.112126. [PMID: 33721663] - Tarana Arman, Katherine D Lynch, Michael Goedken, John D Clarke. Sub-chronic microcystin-LR renal toxicity in rats fed a high fat/high cholesterol diet.
Chemosphere.
2021 Apr; 269(?):128773. doi:
10.1016/j.chemosphere.2020.128773. [PMID: 33143886] - Hui Zeng, Yao Tan, Lingqiao Wang, Menglong Xiang, Ziyuan Zhou, Ji-An Chen, Jia Wang, Renping Zhang, Yingqiao Tian, Jiaohua Luo, Yujing Huang, Chen Lv, Weiqun Shu, Zhiqun Qiu. Association of serum microcystin levels with neurobehavior of school-age children in rural area of Southwest China: A cross-sectional study.
Ecotoxicology and environmental safety.
2021 Apr; 212(?):111990. doi:
10.1016/j.ecoenv.2021.111990. [PMID: 33524912] - Małgorzata Kucała, Michał Saładyga, Ariel Kaminski. Phytoremediation of CYN, MC-LR and ANTX-a from Water by the Submerged Macrophyte Lemna trisulca.
Cells.
2021 03; 10(3):. doi:
10.3390/cells10030699. [PMID: 33801135] - Chongxin Xu, Dan He, Yao Zu, Sujuan Hong, Jia Hao, Jianhong Li. Microcystin-LR heterologous genetically engineered antibody recombinant and its binding activity improvement and application in immunoassay.
Journal of hazardous materials.
2021 03; 406(?):124596. doi:
10.1016/j.jhazmat.2020.124596. [PMID: 33307449] - Babita Deep Srivastava, Manish Srivastava, Sunil Kumar Srivastav, Makoto Urata, Nobuo Suzuki, Ajai Kumar Srivastav. Ameliorative effects of jamun seed and orange peel extracts on microcystin LR induced alterations in calcitonin cells and parathyroid gland of rats.
Microscopy research and technique.
2021 Mar; 84(3):571-578. doi:
10.1002/jemt.23615. [PMID: 33135864] - Gui-Li Yang, Meng-Jun Huang, Ai-Juan Tan, Shi-Ming Lv. Joint effects of naphthalene and microcystin-LR on physiological responses and toxin bioaccumulation of Landoltia punctata.
Aquatic toxicology (Amsterdam, Netherlands).
2021 Feb; 231(?):105710. doi:
10.1016/j.aquatox.2020.105710. [PMID: 33338701] - Neil Chernoff, Donna Hill, Johnsie Lang, Judith Schmid, Amy Farthing, Hwa Huang. Dose-Response Study of Microcystin Congeners MCLA, MCLR, MCLY, MCRR, and MCYR Administered Orally to Mice.
Toxins.
2021 01; 13(2):. doi:
10.3390/toxins13020086. [PMID: 33498948] - Pratik Kumar, Maximiliano Cledon, Satinder Kaur Brar. A low-cost graphitized sand filter to deliver MC-LR-free potable water: Water treatment plants and household perspective.
The Science of the total environment.
2020 Dec; 747(?):141135. doi:
10.1016/j.scitotenv.2020.141135. [PMID: 32795791] - Li He, Lin Liu, Changgao Lin, Jiming Ruan, Ximei Liang, Ying Zhou, Lili Wei. Effects of MC-LR on histological structure and cell apoptosis in the kidney of grass carp (Ctenopharyngodon idella).
Fish physiology and biochemistry.
2020 Dec; 46(6):2005-2014. doi:
10.1007/s10695-020-00833-5. [PMID: 32712898] - Massimo Picardo, Josep Sanchís, Oscar Núñez, Marinella Farré. Suspect screening of natural toxins in surface and drinking water by high performance liquid chromatography and high-resolution mass spectrometry.
Chemosphere.
2020 Dec; 261(?):127888. doi:
10.1016/j.chemosphere.2020.127888. [PMID: 33113669] - Qing Cao, Weijing Liu, Yurong Gu, Liqiang Xie, Weili Jiang, Yan Gao, Liuyan Yang. Synergetic enhancement toxicity of copper, cadmium and microcystin-LR to the Ceratophyllum demersum L.
Toxicon : official journal of the International Society on Toxinology.
2020 Oct; 186(?):151-159. doi:
10.1016/j.toxicon.2020.08.008. [PMID: 32798503] - Daniela Sedan, Luciano Malaissi, Cristian Adrián Vaccarini, Ezequiel Ventosi, Martín Laguens, Lorena Rosso, Leda Giannuzzi, Darío Andrinolo. [D-Leu1]MC-LR Has Lower PP1 Inhibitory Capability and Greater Toxic Potency than MC-LR in Animal and Plant Tissues.
Toxins.
2020 10; 12(10):. doi:
10.3390/toxins12100632. [PMID: 33019556] - Luciano Malaissi, Cristian Adrián Vaccarini, Marcelo Paulo Hernández, Marcela Ruscitti, Cecilia Arango, Federico Busquets, Ana María Arambarri, Leda Giannuzzi, Darío Andrinolo, Daniela Sedan. [D-Leu1]MC-LR and MC-LR: A Small-Large Difference: Significantly Different Effects on Phaseolus vulgaris L. (Fabaceae) Growth and Phototropic Response after Single Contact during Imbibition with Each of These Microcystin Variants.
Toxins.
2020 09; 12(9):. doi:
10.3390/toxins12090585. [PMID: 32932764] - D Pappas, S Gkelis, E Panteris. The effects of microcystin-LR in Oryza sativa root cells: F-actin as a new target of cyanobacterial toxicity.
Plant biology (Stuttgart, Germany).
2020 Sep; 22(5):839-849. doi:
10.1111/plb.13120. [PMID: 32268449] - Guoyuan Chen, Zhihong Zheng, Mingxian Bai, Qingsong Li. Chronic effects of microcystin-LR at environmental relevant concentrations on photosynthesis of Typha angustifolia Linn.
Ecotoxicology (London, England).
2020 Jul; 29(5):514-523. doi:
10.1007/s10646-020-02196-2. [PMID: 32277321] - Yu Chen, Kun Chen, Yuan Zhou, Xingjia Li, Xiaodong Mao, Xiao Wei, Yijiao Xu, Wanwei Yang, Guofang Chen, Chao Liu. Microcystin-LR impairs glucose metabolism in pancreatic β cells in vivo and in vitro.
Toxicology letters.
2020 Jun; 326(?):106-113. doi:
10.1016/j.toxlet.2020.03.003. [PMID: 32142839] - Qi Li, Peng Gu, Chen Zhang, Xin Luo, Hao Zhang, Jibiao Zhang, Zheng Zheng. Combined toxic effects of anatoxin-a and microcystin-LR on submerged macrophytes and biofilms.
Journal of hazardous materials.
2020 05; 389(?):122053. doi:
10.1016/j.jhazmat.2020.122053. [PMID: 31978825] - Lingkai Wang, Wang Lin, Qingji Zha, Honghui Guo, Dandan Zhang, Liping Yang, Li Li, Dapeng Li, Rong Tang. Persistent Exposure to Environmental Levels of Microcystin-LR Disturbs Cortisol Production via Hypothalamic-Pituitary-Interrenal (HPI) Axis and Subsequently Liver Glucose Metabolism in Adult Male Zebrafish (Danio rerio).
Toxins.
2020 04; 12(5):. doi:
10.3390/toxins12050282. [PMID: 32353954] - Wanda Czyżewska, Marlena Piontek, Katarzyna Łuszczyńska. The Occurrence of Potential Harmful Cyanobacteria and Cyanotoxins in the Obrzyca River (Poland), a Source of Drinking Water.
Toxins.
2020 04; 12(5):. doi:
10.3390/toxins12050284. [PMID: 32354080] - Zhen-Lin Xu, Song-Ling Ye, Lin Luo, Xiude Hua, Jing-Xian Lai, Xiang-Ping Cai, Qing-Wen Liang, Hong-Tao Lei, Yuan-Ming Sun, Yi-Ping Chen, Xing Shen. Fluorescent enzyme-linked immunoassay based on silane-doped carbon dots for sensitive detection of microcystin-LR in water and crucian samples.
The Science of the total environment.
2020 Mar; 708(?):134614. doi:
10.1016/j.scitotenv.2019.134614. [PMID: 31806319] - Yunni Gao, Jing Lu, Philip T Orr, Ann Chuang, Hannah M Franklin, Michele A Burford. Enhanced resistance of co-existing toxigenic and non-toxigenic Microcystis aeruginosa to pyrogallol compared with monostrains.
Toxicon : official journal of the International Society on Toxinology.
2020 Mar; 176(?):47-54. doi:
10.1016/j.toxicon.2020.01.013. [PMID: 32103795] - Dandan Zhang, Wang Lin, Yinjie Liu, Honghui Guo, Lingkai Wang, Liping Yang, Li Li, Dapeng Li, Rong Tang. Chronic Microcystin-LR Exposure Induces Abnormal Lipid Metabolism via Endoplasmic Reticulum Stress in Male Zebrafish.
Toxins.
2020 02; 12(2):. doi:
10.3390/toxins12020107. [PMID: 32046144] - Wang Lin, Honghui Guo, Lingkai Wang, Dandan Zhang, Xueyang Wu, Li Li, Yuming Qiu, Liping Yang, Dapeng Li, Rong Tang. Waterborne microcystin-LR exposure induced chronic inflammatory response via MyD88-dependent toll-like receptor signaling pathway in male zebrafish.
The Science of the total environment.
2020 Feb; 702(?):134969. doi:
10.1016/j.scitotenv.2019.134969. [PMID: 31710851] - Yuan Zhou, Menghan Sun, Ye Tang, Yu Chen, Chan Zhu, Yan Yang, Changming Wang, Guang Yu, Zongxiang Tang. Responses of the proteome in testis of mice exposed chronically to environmentally relevant concentrations of Microcystin-LR.
Ecotoxicology and environmental safety.
2020 Jan; 187(?):109824. doi:
10.1016/j.ecoenv.2019.109824. [PMID: 31654863] - Ayman Al-Hazmi. Antioxidant Activity of Silymarin in Microcystin-LR Cardiac and Pulmonary Induced Injuries on Mice.
Pakistan journal of biological sciences : PJBS.
2020 Jan; 23(11):1369-1373. doi:
10.3923/pjbs.2020.1369.1373. [PMID: 33274863] - Abdullah A AlKahtane, Abdelrahman Ibrahim Abushouk, Eman T Mohammed, Moonerah ALNasser, Saud Alarifi, Daoud Ali, Mohammed S Alessia, Rafa S Almeer, Gadah AlBasher, Saad Alkahtani, Lotfi Aleya, Mohamed M Abdel-Daim. Fucoidan alleviates microcystin-LR-induced hepatic, renal, and cardiac oxidative stress and inflammatory injuries in mice.
Environmental science and pollution research international.
2020 Jan; 27(3):2935-2944. doi:
10.1007/s11356-019-06931-z. [PMID: 31838672] - Xiang Wan, Alan D Steinman, Xiubo Shu, Qing Cao, Lei Yao, Liqiang Xie. Combined toxic effects of microcystin-LR and phenanthrene on growth and antioxidant system of duckweed (Lemna gibba L.).
Ecotoxicology and environmental safety.
2019 Dec; 185(?):109668. doi:
10.1016/j.ecoenv.2019.109668. [PMID: 31574372] - Xiping Yi, Shuaishuai Xu, Feiyu Huang, Cong Wen, Shuilin Zheng, Hai Feng, Jian Guo, Jihua Chen, Xiangling Feng, And Fei Yang. Effects of Chronic Exposure to Microcystin-LR on Kidney in Mice.
International journal of environmental research and public health.
2019 12; 16(24):. doi:
10.3390/ijerph16245030. [PMID: 31835602] - Qin Wu, Wei Yan, Chunsheng Liu, Tien-Chieh Hung, Guangyu Li. Co-exposure with titanium dioxide nanoparticles exacerbates MCLR-induced brain injury in zebrafish.
The Science of the total environment.
2019 Nov; 693(?):133540. doi:
10.1016/j.scitotenv.2019.07.346. [PMID: 31374495] - Elane D C Oliveira, Raquel Castelo-Branco, Luis Silva, Natalina Silva, Joana Azevedo, Vitor Vasconcelos, Silvia Faustino, Alan Cunha. First Detection of Microcystin-LR in the Amazon River at the Drinking Water Treatment Plant of the Municipality of Macapá, Brazil.
Toxins.
2019 11; 11(11):. doi:
10.3390/toxins11110669. [PMID: 31731712] - Elisa D'Angelo. Development and evaluation of a sensitive, Diffusive Gradients in Thin-Films (DGT) method for determining microcystin-LR concentrations in freshwater and seawater.
Harmful algae.
2019 11; 89(?):101668. doi:
10.1016/j.hal.2019.101668. [PMID: 31672238] - Leila Ait Abderrahim, Khaled Taïbi, Nawel Ait Abderrahim, Anas M Alomery, Fatiha Abdellah, Ayman Saeed Alhazmi, Saad Aljassabi. Protective effects of melatonin and N-acetyl cysteine against oxidative stress induced by microcystin-LR on cardiac muscle tissue.
Toxicon : official journal of the International Society on Toxinology.
2019 Nov; 169(?):38-44. doi:
10.1016/j.toxicon.2019.08.005. [PMID: 31465783] - Dariusz Dziga, Mikołaj Kokociński, Jakub Barylski, Grzegorz Nowicki, Anna Maksylewicz, Adam Antosiak, Agnieszka Katarzyna Banaś, Wojciech Strzałka. Correlation between specific groups of heterotrophic bacteria and microcystin biodegradation in freshwater bodies of central Europe.
FEMS microbiology ecology.
2019 11; 95(11):. doi:
10.1093/femsec/fiz162. [PMID: 31609415] - Khalil Abnous, Noor Mohammad Danesh, Morteza Alinezhad Nameghi, Mohammad Ramezani, Mona Alibolandi, Parirokh Lavaee, Seyed Mohammad Taghdisi. An ultrasensitive electrochemical sensing method for detection of microcystin-LR based on infinity-shaped DNA structure using double aptamer and terminal deoxynucleotidyl transferase.
Biosensors & bioelectronics.
2019 Nov; 144(?):111674. doi:
10.1016/j.bios.2019.111674. [PMID: 31518788] - Stephan Pflugmacher, Amalia Sulk, Sanghun Kim, Maranda Esterhuizen-Londt. Translocation of the cyanobacterial toxin microcystin-LR into guttation drops of Triticum aestivum and remaining toxicity.
Environmental pollution (Barking, Essex : 1987).
2019 Oct; 253(?):61-67. doi:
10.1016/j.envpol.2019.07.027. [PMID: 31302403] - Ji Zhao, Hong-Qiang Chen, Hui-Fang Yang, Yan Li, Dong-Jiao Chen, Yu-Jing Huang, Li-Xiong He, Chuan-Fen Zheng, Ling-Qiao Wang, Jia Wang, Na Zhang, Jia Cao, Jin-Yi Liu, Wei-Qun Shu, Wen-Bin Liu. Epigenetic silencing of ALX4 regulates microcystin-LR induced hepatocellular carcinoma through the P53 pathway.
The Science of the total environment.
2019 Sep; 683(?):317-330. doi:
10.1016/j.scitotenv.2019.05.144. [PMID: 31132711] - Apurva Lad, Robin C Su, Joshua D Breidenbach, Paul M Stemmer, Nicholas J Carruthers, Nayeli K Sanchez, Fatimah K Khalaf, Shungang Zhang, Andrew L Kleinhenz, Prabhatchandra Dube, Chrysan J Mohammed, Judy A Westrick, Erin L Crawford, Dilrukshika Palagama, David Baliu-Rodriguez, Dragan Isailovic, Bruce Levison, Nikolai Modyanov, Amira F Gohara, Deepak Malhotra, Steven T Haller, David J Kennedy. Chronic Low Dose Oral Exposure to Microcystin-LR Exacerbates Hepatic Injury in a Murine Model of Non-Alcoholic Fatty Liver Disease.
Toxins.
2019 08; 11(9):. doi:
10.3390/toxins11090486. [PMID: 31450746] - Yun-Li Wu, Yun He, Jia-Jian Shi, Tian-Xiu Zheng, Xin-Jian Lin, Xu Lin. Microcystin-LR promotes necroptosis in primary mouse hepatocytes by overproducing reactive oxygen species.
Toxicology and applied pharmacology.
2019 08; 377(?):114626. doi:
10.1016/j.taap.2019.114626. [PMID: 31201821] - Guoyuan Chen, Qingsong Li, Mingxian Bai, Ying Chen. Nitrogen Metabolism in Acorus calamus L. Leaves Induced Changes in Response to Microcystin-LR at Environmentally Relevant Concentrations.
Bulletin of environmental contamination and toxicology.
2019 Aug; 103(2):280-285. doi:
10.1007/s00128-019-02597-y. [PMID: 31069404] - Yuan Zhou, Yu Chen, Xueqin Hu, Jun Guo, Hao Shi, Guang Yu, Zongxiang Tang. Icariin attenuate microcystin-LR-induced gap junction injury in Sertoli cells through suppression of Akt pathways.
Environmental pollution (Barking, Essex : 1987).
2019 Aug; 251(?):328-337. doi:
10.1016/j.envpol.2019.04.114. [PMID: 31091496] - Tarana Arman, Katherine D Lynch, Michelle L Montonye, Michael Goedken, John D Clarke. Sub-Chronic Microcystin-LR Liver Toxicity in Preexisting Diet-Induced Nonalcoholic Steatohepatitis in Rats.
Toxins.
2019 07; 11(7):. doi:
10.3390/toxins11070398. [PMID: 31323923] - Pratik Kumar, Heidi Dayana Pascagaza Rubio, Krishnamoorthy Hegde, Satinder Kaur Brar, Maximiliano Cledon, Azadeh Kermanshahi-Pour, Sébastien Sauvé, Audrey Roy-Lachapelle, Rosa Galvez-Cloutier. Agro-industrial residues as a unique support in a sand filter to enhance the bioactivity to remove microcystin-Leucine aRginine and organics.
The Science of the total environment.
2019 Jun; 670(?):971-981. doi:
10.1016/j.scitotenv.2019.03.260. [PMID: 31018439] - Zhengzong Wu, Deyun He, Bo Cui, Zhengyu Jin. Ultrasensitive detection of microcystin-LR with gold immunochromatographic assay assisted by a molecular imprinting technique.
Food chemistry.
2019 Jun; 283(?):517-521. doi:
10.1016/j.foodchem.2019.01.064. [PMID: 30722906] - Elikanah Olusayo Adegoke, Samson Olugbenga Adeniran, Yue Zeng, Xue Wang, Hao Wang, Chen Wang, Han Zhang, Peng Zheng, Guixue Zhang. Pharmacological inhibition of TLR4/NF-κB with TLR4-IN-C34 attenuated microcystin-leucine arginine toxicity in bovine Sertoli cells.
Journal of applied toxicology : JAT.
2019 06; 39(6):832-843. doi:
10.1002/jat.3771. [PMID: 30671980] - Nathan Dias Martins, João Sarkis Yunes, David J Mckenzie, Francisco Tadeu Rantin, Ana Lúcia Kalinin, Diana Amaral Monteiro. Microcystin - LR exposure causes cardiorespiratory impairments and tissue oxidative damage in trahira, Hoplias malabaricus.
Ecotoxicology and environmental safety.
2019 May; 173(?):436-443. doi:
10.1016/j.ecoenv.2019.02.053. [PMID: 30798187] - Feifei Lei, Xu Lei, Rugui Li, Huabing Tan. Microcystin-LR in peripheral circulation worsens the prognosis partly through oxidative stress in patients with hepatocellular carcinoma.
Clinical and experimental medicine.
2019 May; 19(2):235-243. doi:
10.1007/s10238-019-00550-1. [PMID: 30859346] - Deyun He, Zhengzong Wu, Bo Cui, Zhengyu Jin. A novel SERS-based aptasensor for ultrasensitive sensing of microcystin-LR.
Food chemistry.
2019 Apr; 278(?):197-202. doi:
10.1016/j.foodchem.2018.11.071. [PMID: 30583362] - John D Clarke, Anika Dzierlenga, Tarana Arman, Erica Toth, Hui Li, Katherine D Lynch, Dan-Dan Tian, Michael Goedken, Mary F Paine, Nathan Cherrington. Nonalcoholic fatty liver disease alters microcystin-LR toxicokinetics and acute toxicity.
Toxicon : official journal of the International Society on Toxinology.
2019 Apr; 162(?):1-8. doi:
10.1016/j.toxicon.2019.03.002. [PMID: 30849452] - Xiaoyu Li, Jing Li, Fanxiao Meng, Lan Yao. Hepatotoxicity and immunotoxicity of MC-LR on silver carp.
Ecotoxicology and environmental safety.
2019 Mar; 169(?):28-32. doi:
10.1016/j.ecoenv.2018.10.110. [PMID: 30412895] - Anna-Cathrine Neumann, Stanislav Melnik, Reinhard Niessner, Eva Stoeger, Dietmar Knopp. Microcystin-LR Enrichment from Freshwater by a Recombinant Plant-derived Antibody Using Sol-Gel-Glass Immunoextraction.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.
2019 Feb; 35(2):207-214. doi:
10.2116/analsci.18p384. [PMID: 30318489] - Jordan A Facey, Joel R Steele, Jake P Violi, Simon M Mitrovic, Charles Cranfield. An examination of microcystin-LR accumulation and toxicity using tethered bilayer lipid membranes (tBLMs).
Toxicon : official journal of the International Society on Toxinology.
2019 Feb; 158(?):51-56. doi:
10.1016/j.toxicon.2018.11.432. [PMID: 30521837] - Zhikuan Wang, Guangyu Li, Qin Wu, Chunsheng Liu, JianZhong Shen, Wei Yan. Microcystin-LR exposure induced nephrotoxicity by triggering apoptosis in female zebrafish.
Chemosphere.
2019 Jan; 214(?):598-605. doi:
10.1016/j.chemosphere.2018.09.103. [PMID: 30290360] - Maciej Florczyk, Paweł Brzuzan, Alicja Łakomiak, Ewa Jakimiuk, Maciej Woźny. Microcystin-LR-Triggered Neuronal Toxicity in Whitefish Does Not Involve MiR124-3p.
Neurotoxicity research.
2019 Jan; 35(1):29-40. doi:
10.1007/s12640-018-9920-4. [PMID: 29882005] - E O Adegoke, Wang Xue, N S Machebe, S O Adeniran, Wang Hao, Wang Chen, Zhang Han, Zhang Guixue, Zheng Peng. Sodium Selenite inhibits mitophagy, downregulation and mislocalization of blood-testis barrier proteins of bovine Sertoli cell exposed to microcystin-leucine arginine (MC-LR) via TLR4/NF-kB and mitochondrial signaling pathways blockage.
Ecotoxicology and environmental safety.
2018 Dec; 166(?):165-175. doi:
10.1016/j.ecoenv.2018.09.073. [PMID: 30267989] - Wang Lin, Honghui Guo, Lingkai Wang, Dandan Zhang, Xueyang Wu, Li Li, Dapeng Li, Rong Tang. Nitrite Enhances MC-LR-Induced Changes on Splenic Oxidation Resistance and Innate Immunity in Male Zebrafish.
Toxins.
2018 12; 10(12):. doi:
10.3390/toxins10120512. [PMID: 30513985] - Jing Wang, Yabing Chen, Zhangpeng Chen, Zou Xiang, Jie Ding, Xiaodong Han. Microcystin-leucine arginine inhibits gonadotropin-releasing hormone synthesis in mice hypothalamus.
Ecotoxicology and environmental safety.
2018 Nov; 163(?):391-399. doi:
10.1016/j.ecoenv.2018.07.094. [PMID: 30064084] - Pratik Kumar, Krishnamoorthy Hegde, Satinder Kaur Brar, Maximiliano Cledon, Azadeh Kermanshahi-Pour, Audrey Roy-Lachapelle, Rosa Galvez-Cloutier. Biodegradation of microcystin-LR using acclimatized bacteria isolated from different units of the drinking water treatment plant.
Environmental pollution (Barking, Essex : 1987).
2018 Nov; 242(Pt A):407-416. doi:
10.1016/j.envpol.2018.07.008. [PMID: 30005254] - Julie P Meneely, Jana Hajšlová, Rudolf Krska, Christopher T Elliott. Assessing the combined toxicity of the natural toxins, aflatoxin B1, fumonisin B1 and microcystin-LR by high content analysis.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2018 Nov; 121(?):527-540. doi:
10.1016/j.fct.2018.09.052. [PMID: 30253246] - Rui Wang, Yiping Tai, Xiang Wan, Weifeng Ruan, Ying Man, Jiaxi Wang, Yufen Yang, Yang Yang. Enhanced removal of Microcystis bloom and microcystin-LR using microcosm constructed wetlands with bioaugmentation of degrading bacteria.
Chemosphere.
2018 Nov; 210(?):29-37. doi:
10.1016/j.chemosphere.2018.06.140. [PMID: 29980069] - Yulin Tang, Huaijia Xin, Shu Yang, Meiting Guo, Tyler Malkoske, Daqiang Yin, Shengji Xia. Environmental risks of ZnO nanoparticle exposure on Microcystis aeruginosa: Toxic effects and environmental feedback.
Aquatic toxicology (Amsterdam, Netherlands).
2018 Nov; 204(?):19-26. doi:
10.1016/j.aquatox.2018.08.010. [PMID: 30170208] - Igor Mrdjen, Mark A Morse, Randall J Ruch, Thomas J Knobloch, Shambhunath Choudhary, Christopher M Weghorst, Jiyoung Lee. Impact of Microcystin-LR on Liver Function Varies by Dose and Sex in Mice.
Toxins.
2018 Oct; 10(11):. doi:
10.3390/toxins10110435. [PMID: 30373283] - Liang Chen, Yeke Wang, John P Giesy, Feng Chen, Ting Shi, Jun Chen, Ping Xie. Microcystin-LR affects the hypothalamic-pituitary-inter-renal (HPI) axis in early life stages (embryos and larvae) of zebrafish.
Environmental pollution (Barking, Essex : 1987).
2018 Oct; 241(?):540-548. doi:
10.1016/j.envpol.2018.05.024. [PMID: 29883955] - Rebekah E Wharton, Geovannie Ojeda-Torres, Brady Cunningham, Melanie C Feyereisen, Kasey L Hill, Nicole L Abbott, Craig Seymour, Donna Hill, Johnsie Lang, Elizabeth I Hamelin, Rudolph C Johnson. Quantification of Microcystin-LR in Human Urine by Immunocapture Liquid Chromatography Tandem Mass Spectrometry.
Chemical research in toxicology.
2018 09; 31(9):898-903. doi:
10.1021/acs.chemrestox.8b00126. [PMID: 30133262] - Qiong Zhang, Wendi Qin, Liuyan Yang, Jing An, Xuxiang Zhang, Hao Hong, Lizhi Xu, Yaping Wang. Microcystis bloom containing microcystin-LR induces type 2 diabetes mellitus.
Toxicology letters.
2018 Sep; 294(?):87-94. doi:
10.1016/j.toxlet.2018.05.019. [PMID: 29777831] - Xiaofen Wang, Lizhi Xu, Xinxiu Li, Jingwen Chen, Wei Zhou, Jiapeng Sun, Yaping Wang. The differential effects of microcystin-LR on mitochondrial DNA in the hippocampus and cerebral cortex.
Environmental pollution (Barking, Essex : 1987).
2018 Sep; 240(?):68-76. doi:
10.1016/j.envpol.2018.04.103. [PMID: 29729571] - Qing Cao, Alan D Steinman, Xiang Wan, Liqiang Xie. Bioaccumulation of microcystin congeners in soil-plant system and human health risk assessment: A field study from Lake Taihu region of China.
Environmental pollution (Barking, Essex : 1987).
2018 Sep; 240(?):44-50. doi:
10.1016/j.envpol.2018.04.067. [PMID: 29729568]
