pipobroman (BioDeep_00001867696)

Main id: BioDeep_00000006490

 


代谢物信息卡片


pipobroman

化学式: C10H16Br2N2O2 (353.9578)
中文名称: 哌泊溴烷
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(CBr)C(=O)N1CCN(CC1)C(=O)CCBr
InChI: InChI=1S/C10H16Br2N2O2/c11-3-1-9(15)13-5-7-14(8-6-13)10(16)2-4-12/h1-8H2

描述信息

L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01A - Alkylating agents
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent
D009676 - Noxae > D000477 - Alkylating Agents
D000970 - Antineoplastic Agents

同义名列表

2 个代谢物同义名

pipobroman; Pipobroman



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 ABL1, BRAF, JAK2, MME, TP53
Peripheral membrane protein 1 JAK2
Endoplasmic reticulum membrane 1 HSP90B1
Nucleus 11 ABL1, ASXL1, BRAF, CEBPA, EZH2, HSP90B1, JAK2, MPO, RUNX1, SRSF2, TP53
cytosol 8 ABL1, BRAF, HSP90B1, IDH2, JAK2, SH2B3, SRSF2, TP53
dendrite 2 ABL1, MME
nuclear body 1 ABL1
trans-Golgi network 1 MME
centrosome 1 TP53
nucleoplasm 9 ABL1, ASXL1, CEBPA, EZH2, JAK2, MPO, RUNX1, SRSF2, TP53
RNA polymerase II transcription regulator complex 1 CEBPA
Cell membrane 2 BRAF, MME
Synapse 2 EZH2, MME
cell surface 3 EPO, ITGA2B, MME
glutamatergic synapse 3 ABL1, BRAF, JAK2
growth cone 1 ABL1
neuronal cell body 2 ABL1, MME
postsynapse 3 ABL1, BRAF, JAK2
smooth endoplasmic reticulum 1 HSP90B1
synaptic vesicle 1 MME
Lysosome 1 MPO
Presynapse 2 BRAF, MME
plasma membrane 9 ABL1, BCHE, BRAF, IFNLR1, ITGA2B, JAK2, MME, PRSS27, SH2B3
Membrane 6 HSP90B1, IFNLR1, ITGA2B, JAK2, MME, TP53
axon 1 MME
brush border 1 MME
caveola 1 JAK2
extracellular exosome 6 EPO, HSP90B1, IDH2, ITGA2B, MME, MPO
endoplasmic reticulum 2 HSP90B1, TP53
extracellular space 4 BCHE, EPO, IFNA1, MPO
perinuclear region of cytoplasm 2 ABL1, HSP90B1
mitochondrion 4 ABL1, BRAF, IDH2, TP53
protein-containing complex 3 ABL1, HSP90B1, TP53
intracellular membrane-bounded organelle 4 BRAF, CEBPA, MPO, RUNX1
postsynaptic density 1 ABL1
chromatin silencing complex 1 EZH2
ESC/E(Z) complex 1 EZH2
pericentric heterochromatin 1 EZH2
pronucleus 1 EZH2
Single-pass type I membrane protein 2 IFNLR1, ITGA2B
Secreted 3 BCHE, EPO, IFNA1
extracellular region 5 BCHE, EPO, HSP90B1, MPO, PRSS27
cytoplasmic side of plasma membrane 1 JAK2
Mitochondrion matrix 1 TP53
mitochondrial matrix 2 IDH2, TP53
transcription regulator complex 2 CEBPA, TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
nuclear membrane 1 ABL1
external side of plasma membrane 1 ITGA2B
actin cytoskeleton 1 ABL1
cytoplasmic vesicle 1 MME
nucleolus 3 ABL1, CEBPA, TP53
midbody 1 HSP90B1
Early endosome 1 MME
Single-pass type II membrane protein 1 MME
Membrane raft 2 JAK2, MME
Cytoplasm, cytoskeleton 1 TP53
focal adhesion 4 HSP90B1, ITGA2B, JAK2, MME
Peroxisome 1 IDH2
Nucleus, PML body 1 TP53
PML body 1 TP53
collagen-containing extracellular matrix 1 HSP90B1
secretory granule 1 MPO
nuclear speck 1 SRSF2
ruffle 1 ABL1
neuron projection 1 BRAF
chromatin 4 CEBPA, EZH2, RUNX1, TP53
Chromosome 1 EZH2
cytoskeleton 1 JAK2
chromosome, telomeric region 1 EZH2
blood microparticle 2 BCHE, ITGA2B
spliceosomal complex 1 SRSF2
site of double-strand break 1 TP53
Endomembrane system 1 JAK2
endosome lumen 1 JAK2
Nucleus, nucleoplasm 1 SRSF2
Melanosome 1 HSP90B1
Nucleus speckle 1 SRSF2
euchromatin 1 JAK2
cell body 2 BRAF, EPO
germ cell nucleus 1 TP53
replication fork 1 TP53
sperm plasma membrane 1 HSP90B1
azurophil granule 1 MPO
secretory granule lumen 1 EPO
secretory granule membrane 1 MME
endoplasmic reticulum lumen 2 BCHE, HSP90B1
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
azurophil granule lumen 1 MPO
nuclear envelope lumen 1 BCHE
Sarcoplasmic reticulum lumen 1 HSP90B1
phagocytic vesicle lumen 1 MPO
[Isoform 1]: Nucleus 1 TP53
extrinsic component of cytoplasmic side of plasma membrane 1 JAK2
perichromatin fibrils 1 SRSF2
extrinsic component of plasma membrane 1 JAK2
granulocyte macrophage colony-stimulating factor receptor complex 1 JAK2
interleukin-12 receptor complex 1 JAK2
interleukin-23 receptor complex 1 JAK2
platelet alpha granule membrane 1 ITGA2B
integrin complex 1 ITGA2B
endocytic vesicle lumen 1 HSP90B1
integrin alphaIIb-beta3 complex 1 ITGA2B
endoplasmic reticulum chaperone complex 1 HSP90B1
neuron projection terminus 1 MME
C/EBP complex 1 CEBPA
CHOP-C/EBP complex 1 CEBPA
[Isoform 4]: Nucleus, nucleolus 1 CEBPA
interchromatin granule 1 SRSF2
core-binding factor complex 1 RUNX1
interleukin-28 receptor complex 1 IFNLR1
PR-DUB complex 1 ASXL1


文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • E K Zsigmond, S P Kothary. [Effect of pibobroman on human plasma cholinesterase activity in vitro]. Anesthesie, analgesie, reanimation. 1975 Mar; 32(2):167-9. doi: . [PMID: 1229916]