tetrachloromethane (BioDeep_00001867610)
Main id: BioDeep_00000006539
PANOMIX_OTCML-2023
代谢物信息卡片
CARBON TETRACHLORIDE
化学式: CCl4 (151.8754)
中文名称: 四氯化碳标准溶液, 四氯化碳
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(Cl)(Cl)(Cl)Cl
InChI: InChI=1S/CCl4/c2-1(3,4)5
描述信息
同义名列表
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:27385
- KEGG: C07561
- PubChem: 5943
- ChEMBL: CHEMBL44814
- MeSH: Carbon Tetrachloride
- CAS: 56-23-5
- PubChem: 9764
- NIKKAJI: J2.317E
- KNApSAcK: 27385
分类词条
相关代谢途径
Reactome(6)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
- 4233 - Helianthus tuberosus: 10.1016/S0031-9422(82)85033-4
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yusheng Zhao, Hui Kong, Yuru Li, Yafang Zhao, Yue Zhang, Yan Zhao, Huihua Qu. Inhibitory effects of Curcumae Radix carbonisata-based carbon dots against liver fibrosis induced by carbon tetrachloride in mice.
Artificial cells, nanomedicine, and biotechnology.
2024 Dec; 52(1):23-34. doi:
10.1080/21691401.2023.2239522. [PMID: 38035609] - Siting Xian, Yonggang Yang, Nan Nan, Xiaolong Fu, Jingshan Shi, Qin Wu, Shaoyu Zhou. Inhibition of mitochondrial ROS-mediated necroptosis by Dendrobium nobile Lindl. alkaloids in carbon tetrachloride induced acute liver injury.
Journal of ethnopharmacology.
2024 Aug; 330(?):118253. doi:
10.1016/j.jep.2024.118253. [PMID: 38679400] - Yan Xue, Wanchun Zhu, Fengjie Qiao, Yilan Yang, Jiaohao Qiu, Chen Zou, Yating Gao, Xin Zhang, Man Li, Zhi Shang, Yueqiu Gao, Lingying Huang. Ba-Qi-Rougan formula alleviates hepatic fibrosis by suppressing hepatic stellate cell activation via the MSMP/CCR2/PI3K pathway.
Journal of ethnopharmacology.
2024 Jul; 329(?):118169. doi:
10.1016/j.jep.2024.118169. [PMID: 38621463] - Mengjia Lv, Shiyi Chen, Mengwen Shan, Yuan Si, Chenggang Huang, Jing Chen, Likun Gong. Arctigenin induces activated HSCs quiescence via AMPK-PPARγ pathway to ameliorate liver fibrosis in mice.
European journal of pharmacology.
2024 Jul; 974(?):176629. doi:
10.1016/j.ejphar.2024.176629. [PMID: 38679116] - Zhihong Zhang, Yanping Sun, Yuanning Zeng, Na Cui, Biao Li, Wensen Zhang, Haodong Bai, Na Xing, Haixue Kuang, Qiuhong Wang. Elucidating the hepatoprotective mechanisms of cholic acid against CCl4-Induced acute liver injury: A transcriptomic and metabolomic study.
Journal of ethnopharmacology.
2024 Jun; 328(?):118052. doi:
10.1016/j.jep.2024.118052. [PMID: 38518967] - Zhiyuan Lv, Jianzhong Song, Yang Xiang, Zhanghao Chen, Zinan Lu, Quanqian Zhou, Kaizhen Wang, Hailiqian Taoer Dahong, Jiarui Zheng, Chunyu Zhang, Shuang Gao, Chunjun Qin, Junmin Chang. Structural characterization and therapeutic effect of Alhagi honey oligosaccharide on liver fibrosis in mice.
Fitoterapia.
2024 Jun; 175(?):105974. doi:
10.1016/j.fitote.2024.105974. [PMID: 38663563] - Qiong Liu, Xin Ba, Liang Han, Jiahui Yan, Zhe Chen, Kai Qin, Shenghao Tu, Pan Shen. Dahuang-Wumei decoction protects against hepatic encephalopathy in mice: Behavioural, biochemical, and molecular evidence.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2024 Jun; 128(?):155419. doi:
10.1016/j.phymed.2024.155419. [PMID: 38522314] - Layanne C C Araujo, Carolina C B Dias, Felipe G Sucupira, Leandra N Z Ramalho, João Paulo Camporez. A short-term rodent model for non-alcoholic steatohepatitis induced by a high-fat diet and carbon tetrachloride.
Bioscience reports.
2024 May; 44(5):. doi:
10.1042/bsr20231532. [PMID: 38660995] - Hanlin Shi, Xiaohong Duan, Jingcheng Dong, Yanyan Tao, Yang Lei. RNA-seq combined network pharmacology reveals that Fu-Gan-Wan (FGW) inhibits liver fibrosis via NF-κB/CCL2/CCR2 and lipid peroxidation via Nrf2/HMOX1 signaling pathway.
Journal of ethnopharmacology.
2024 May; 326(?):117963. doi:
10.1016/j.jep.2024.117963. [PMID: 38387680] - Yanan Guo, Sisi Dong, Meng Li, Yanyan Tao, Jing Lv, Chenghai Liu. A new model of portal vein thrombosis in rats with cirrhosis induced by partial portal vein ligation plus carbon tetrachloride and intervened with rivaroxaban.
BMC gastroenterology.
2024 May; 24(1):161. doi:
10.1186/s12876-024-03253-4. [PMID: 38741060] - Li Tao, Yu-Feng Xue, Fei-Fei Sun, Xue He, Hong-Qian Wang, Cheng-Cheng Tong, Cheng Zhang, De-Xiang Xu, Xi Chen. MitoQ protects against carbon tetrachloride-induced hepatocyte ferroptosis and acute liver injury by suppressing mtROS-mediated ACSL4 upregulation.
Toxicology and applied pharmacology.
2024 May; 486(?):116914. doi:
10.1016/j.taap.2024.116914. [PMID: 38522585] - J Anupama Sekar, Shiny Velayudhan, M Senthilkumar, P R Anil Kumar. Silymarin enriched gelatin methacrylamide bioink imparts hepatoprotectivity to 3D bioprinted liver construct against carbon tetrachloride induced toxicity.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2024 May; 198(?):114272. doi:
10.1016/j.ejpb.2024.114272. [PMID: 38537909] - Leila Kebal, Noureddine Djebli, Katarzyna Pokajewicz, Nadjet Mostefa, Piotr P Wieczorek. Antioxidant Activity and Effectiveness of Fig Extract in Counteracting Carbon Tetrachloride-Induced Oxidative Damage in Rats.
Molecules (Basel, Switzerland).
2024 Apr; 29(9):. doi:
10.3390/molecules29091997. [PMID: 38731494] - Devaraj Ezhilarasan, Karthik Shree Harini, Munusamy Karthick, Prathap Lavanya. Boldine protects against carbon tetrachloride-induced chronic liver injury by regulating NF-κB signaling pathway.
Journal of biochemical and molecular toxicology.
2024 Apr; 38(4):e23691. doi:
10.1002/jbt.23691. [PMID: 38500399] - Eun-Ho Lee, Jae-Ho Lee, Do-Young Kim, Young-Seung Lee, Yunju Jo, Tam Dao, Kyung Eun Kim, Dae-Kyu Song, Ji Hae Seo, Young-Kyo Seo, Je Kyung Seong, Changjong Moon, Eugene Han, Mi Kyung Kim, Seungwan Ryu, Minsang Shin, Gu Seob Roh, Hye Ra Jung, Timothy F Osborne, Dongryeol Ryu, Tae-Il Jeon, Seung-Soon Im. Loss of SREBP-1c ameliorates iron-induced liver fibrosis by decreasing lipocalin-2.
Experimental & molecular medicine.
2024 Apr; 56(4):1001-1012. doi:
10.1038/s12276-024-01213-2. [PMID: 38622198] - Jing Zhang, Wen Wang, Xinge Cui, Pengling Zhu, Siyu Li, Shujie Yuan, Daiyin Peng, Can Peng. Ganoderma lucidum ethanol extracts ameliorate hepatic fibrosis and promote the communication between metabolites and gut microbiota g_Ruminococcus through the NF-κB and TGF-β1/Smads pathways.
Journal of ethnopharmacology.
2024 Mar; 322(?):117656. doi:
10.1016/j.jep.2023.117656. [PMID: 38154526] - Tian Lan, Bo Chen, Xianzhe Hu, Jiafan Cao, Shiyun Chen, Xin Ding, Shengwen Li, Yanfang Fu, Huanle Liu, Duosheng Luo, Xianglu Rong, Jiao Guo. Tianhuang formula ameliorates liver fibrosis by inhibiting CCL2-CCR2 axis and MAPK/NF-κB signaling pathway.
Journal of ethnopharmacology.
2024 Mar; 321(?):117516. doi:
10.1016/j.jep.2023.117516. [PMID: 38042390] - Xiaolan Dai, Zhenyun Du, Can Jin, Bixi Tang, Xia Chen, Xiaoqi Jing, Yumei Shen, Fei He, Shunchun Wang, Jia Li, Kan Ding, Yi Zang. Inulin-like polysaccharide ABWW may impede CCl4 induced hepatic stellate cell activation through mediating the FAK/PI3K/AKT signaling pathway in vitro & in vivo.
Carbohydrate polymers.
2024 Feb; 326(?):121637. doi:
10.1016/j.carbpol.2023.121637. [PMID: 38142102] - Amber Ayaz Memon, Lubna Naz. The hepatoprotective potentials of Olea europaea L. leaves against carbon tetrachloride-induced hepatic injury in rats.
JPMA. The Journal of the Pakistan Medical Association.
2024 Feb; 74(1 (Supple-2)):S63-S67. doi:
10.47391/jpma-duhs-s13. [PMID: 38385474] - Yue Liang, Jing Fang, Xiaoxi Zhou, Zheng Zhang, Wei Liu, Yonghong Hu, Xiaohan Yu, Yongping Mu, Hua Zhang, Ping Liu, Jiamei Chen. Schisantherin A protects hepatocyte via upregulating DDAH1 to ameliorate liver fibrosis in mice.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2024 Feb; 124(?):155330. doi:
10.1016/j.phymed.2023.155330. [PMID: 38185067] - Xiaofeng Chen, Xin Sun, Shaoxiu Ji, Han Yu, Peijie Wu. TMT-based proteomics analysis identifies the interventional mechanisms of Qijia Rougan decoction in improving hepatic fibrosis.
Journal of ethnopharmacology.
2024 Jan; 319(Pt 3):117334. doi:
10.1016/j.jep.2023.117334. [PMID: 37863401] - Abdul Wajid Khalil, Zafar Iqbal, Achyut Adhikari, Hamayun Khan, Umar Nishan, Anwar Iqbal, Javed Abbas Bangash, Omer Mukhtar Tarar, Ahmad Bilal, Shahid Ali Khan, Daniel C Hoessli, Mohammed A Assiri, Zhiyuan Wu, Saifullah Afridi. Spectroscopic characterization of eupalitin-3-O-β-D-galactopyranoside from Boerhavia procumbens: In vivo hepato-protective potential in rat model.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2024 Jan; 304(?):123369. doi:
10.1016/j.saa.2023.123369. [PMID: 37738764] - Heba Nageh Gad El-Hak, Safaa M Kishk, Heba M A Abdelrazek. Evening primrose oil enriched with gamma linolenic acid and D/L-alpha tocopherol acetate attenuated carbon tetrachloride-induced hepatic injury model in male rats via TNF-α, IL-1β, and IL-6 pathway.
Toxicology mechanisms and methods.
2024 Jan; ?(?):1-15. doi:
10.1080/15376516.2023.2301357. [PMID: 38166523] - Luis E Ayala-Hernández, Gabriela Rosales-Muñoz, Armando Gallegos, María L Miranda-Beltrán, Jorge E Macías-Díaz. On a deterministic mathematical model which efficiently predicts the protective effect of a plant extract mixture in cirrhotic rats.
Mathematical biosciences and engineering : MBE.
2024 Jan; 21(1):237-252. doi:
10.3934/mbe.2024011. [PMID: 38303421] - Yawen Hao, Shaohua Song, Tao Li, Qiuhong Zai, Ningning Ma, Yixin Li, Liu Yang, Peng Xiao, Tianyue Xu, Longshan Ji, Jiaxin Tan, Yeni Ait Ahmed, Xiaogang Xiang, Xiaolin Wang, Fouad Lafdil, Qing Xie, Yong He. Oxidative stress promotes liver fibrosis by modulating the microRNA-144 and SIN3A-p38 pathways in hepatic stellate cells.
International journal of biological sciences.
2024; 20(7):2422-2439. doi:
10.7150/ijbs.92749. [PMID: 38725842] - Run Ma, Na Xie, Yuanhui Shu, Yafeng Wu, Ping He, Yining Xiang, Yan Zhou, Yuping Wang. Cannabidiol alleviates carbon tetrachloride-induced liver fibrosis in mice by regulating NF-κB and PPAR-α pathways.
Experimental biology and medicine (Maywood, N.J.).
2024; 249(?):10141. doi:
10.3389/ebm.2024.10141. [PMID: 38711461] - Alex Boye, Ernest Amponsah Asiamah, Orleans Martey, Frederick Ayertey. Citrus limon (L.) Osbeck Fruit Peel Extract Attenuates Carbon Tetrachloride-Induced Hepatocarcinogenesis in Sprague-Dawley Rats.
BioMed research international.
2024; 2024(?):6673550. doi:
10.1155/2024/6673550. [PMID: 38204757] - Fatma Ben Mansour, Habib Ayadi, Jos van Pelt, Abdelfattah Elfeki, Khaled Bellassoued. Antioxidant and Protective Effect of Ocimum basilicum Seeds Extract on Renal Toxicity Induced by Carbon Tetrachloride in Rats.
Journal of medicinal food.
2024 Jan; 27(1):60-71. doi:
10.1089/jmf.2023.0184. [PMID: 38150214] - Junjie Bai, Baolin Qian, Tianying Cai, Yifan Chen, Tongxi Li, Yonglang Cheng, Ziming Wu, Chen Liu, Mingxin Ye, Yichao Du, Wenguang Fu. Aloin Attenuates Oxidative Stress, Inflammation, and CCl4-Induced Liver Fibrosis in Mice: Possible Role of TGF-β/Smad Signaling.
Journal of agricultural and food chemistry.
2023 Dec; 71(49):19475-19487. doi:
10.1021/acs.jafc.3c01721. [PMID: 38038700] - Mamdouh M T Eassawy, Amel F M Ismail. Protective effect of chicory and/or artichoke leaves extracts on carbon tetrachloride and gamma-irradiation-induced chronic nephrotoxicity in rats.
Environmental toxicology.
2023 Nov; ?(?):. doi:
10.1002/tox.24060. [PMID: 38031637] - Shiyuan Jiang, Jing Feng, Yanling Jiang, Zhihao Lu, Jingwei Kong, Xueming Li, Hui Lian, Fang Zhang, Yu Li, Jian Li. Triptolide attenuates CCL4-induced liver fibrosis by regulating the differentiation of CD4+ T cells in mice.
International immunopharmacology.
2023 Nov; 125(Pt B):111206. doi:
10.1016/j.intimp.2023.111206. [PMID: 37956491] - Chen He, Wenjing Wang, Guoli Wei, Yuqing Wang, Yingjie Wei, Jing Wang, Zhenhai Zhang. Sodium alginate combined with oxymatrine ameliorates CCl4-induced chemical hepatic fibrosis in mice.
International immunopharmacology.
2023 Nov; 125(Pt A):111144. doi:
10.1016/j.intimp.2023.111144. [PMID: 37922569] - Hanaa S S Gazwi, Osama I A Soltan, Sanaa M Abdel-Hameed. Cakes fortified with papaya seeds effectively protects against CCl4-induced immunotoxicity.
Environmental science and pollution research international.
2023 Oct; ?(?):. doi:
10.1007/s11356-023-30172-w. [PMID: 37815681] - Rui Cao, Chun Cao, Xiaojie Hu, Kang Du, Jingrong Zhang, Mengxue Li, Bowen Li, Huimin Lin, Anqi Zhang, Yangyang Li, Li Wu, Yan Huang. Kaempferol attenuates carbon tetrachloride (CCl4)-induced hepatic fibrosis by promoting ASIC1a degradation and suppression of the ASIC1a-mediated ERS.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2023 Oct; 121(?):155125. doi:
10.1016/j.phymed.2023.155125. [PMID: 37820466] - Rasha Fekry Zahran, Lina Mahmoud El-Sayed, Thomas Robert Hoye, Seif-Eldin Nasr Ayyad. The Dual Therapeutic Potential of Ottelione A on Carbon Tetrachloride-induced Hepatic Toxicity in Mice.
Applied biochemistry and biotechnology.
2023 Oct; 195(10):5966-5979. doi:
10.1007/s12010-023-04346-8. [PMID: 36729297] - Yong Ye, Bo Zhang, Wanting Mai, Yanjun Tan, Zhongwen Feng, Qiujie Huang. Metabolomics study of the hepatoprotective effect of total flavonoids of Mallotus apelta leaf in carbon tetrachloride-induced liver fibrosis in rats.
Biomedical chromatography : BMC.
2023 Oct; 37(10):e5711. doi:
10.1002/bmc.5711. [PMID: 37593807] - Yi Tao, Ying Yang, Fei Zhu, Mei Wu, Xiangjun Kong, Ping Wang. Serum metabolome profiling, network pharmacology analysis, and experimental validation of Anoectochilus roxburghii in the treatment of carbon tetrachloride-induced liver injury.
Biomedical chromatography : BMC.
2023 Oct; 37(10):e5706. doi:
10.1002/bmc.5706. [PMID: 37491783] - Swati Sharma, Vishal Sharma, Sunil Taneja, Alka Bhatia, Aishwarya Anand, Amol N Patil, Dibyajyoti Banerjee. Scopoletin a potential phytochemical therapy for antitubercular treatment drug induced liver injury (ATT-DILI) model in Wistar rats.
Journal of complementary & integrative medicine.
2023 Sep; ?(?):. doi:
10.1515/jcim-2023-0168. [PMID: 37732506] - Jie Gao, Miaoye Bao, Yuanming Xing, Yiming Ding, Tuo Han, Ergang Wen, Jun Liu, Shaoyun Yue, Rong Wang, Ling Wang, Junhui Liu, Sihai Zhao, Jiansheng Huang, Enqi Liu, Liang Bai. Mediator subunit MED1 deficiency prevents carbon tetrachloride induced hepatic fibrosis in mice.
American journal of physiology. Gastrointestinal and liver physiology.
2023 Sep; ?(?):. doi:
10.1152/ajpgi.00076.2023. [PMID: 37668531] - A A Chulanova, M Yu Smakhtin, I I Bobyntsev, E S Mishina, E B Artyushkova, A M Smakhtina. Reparative and Antioxidant Effects of New Analogues of Immunomodulator Thymogen in Experimental Model of Liver Damage.
Bulletin of experimental biology and medicine.
2023 Sep; 175(5):700-703. doi:
10.1007/s10517-023-05929-5. [PMID: 37861903] - Cecilia Delgado-Montemayor, Jonathan Perez-Meseguer, Ricardo Salazar-Aranda, Paula Cordero-Perez, Noemí Waksman. Hepatodamianol as hepatoprotective constituent of Turnera diffusa.
Pakistan journal of pharmaceutical sciences.
2023 Sep; 36(5):1553-1559. doi:
". [PMID: 37869931] - Floris Haijer, Shiva Koets-Shajari, Janette Heegsma, Sandra Serna-Salas, Tjasso Blokzijl, Manon Buist-Homan, Han Moshage, Klaas Nico Faber. Hydroxyurea attenuates hepatic stellate cell proliferation in vitro and liver fibrogenesis in vivo.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2023 09; 37(9):e23124. doi:
10.1096/fj.202300920r. [PMID: 37552464] - Sadaf Yasmeen, Aslam Khan, Fareeha Anwar, Muhammad Furqan Akhtar, Sidra Yasmeen, Shafeeq Ali Shah. An insight into the hepatoprotective role of Velpatasvir and Sofosbuvir per se and in combination against carbon tetrachloride-induced hepatic fibrosis in rats.
Environmental science and pollution research international.
2023 Aug; ?(?):. doi:
10.1007/s11356-023-29134-z. [PMID: 37556059] - Selcen Çakır. The Effect of Royal Jelly on Telomere Length and Some Biochemical Parameters in Wistar Albino Rats with Liver Damage Caused by Carbon Tetrachloride.
Journal of medicinal food.
2023 Jul; ?(?):. doi:
10.1089/jmf.2023.0042. [PMID: 37477674] - Shiyun Pu, Jingyi Zhang, Changyu Ren, Hongjing Zhou, Yan Wang, Yuanli Wu, Shuangyu Yang, Fangyin Cao, Houfeng Zhou. Montelukast prevents mice against carbon tetrachloride- and methionine-choline deficient diet-induced liver fibrosis: Reducing hepatic stellate cell activation and inflammation.
Life sciences.
2023 Jul; 325(?):121772. doi:
10.1016/j.lfs.2023.121772. [PMID: 37178864] - Yanhui Zhao, Min Zhao, Zheyong Wang, Chunjie Zhao, Yumeng Zhang, Miao Wang. Danggui Shaoyao San: Chemical characterization and inhibition of oxidative stress and inflammation to treat CCl4-induced hepatic fibrosis.
Journal of ethnopharmacology.
2023 Jul; ?(?):116870. doi:
10.1016/j.jep.2023.116870. [PMID: 37423517] - Syed Kashif Ali, Hafiz A Makeen, Gulrana Khuwaja, Hassan A Alhazmi, Mukul Sharma, Afraim Koty, Islam Mazahirul, Humaira Parveen, Asaduddin Mohammed, Sayeed Mukhtar, Mohammad Firoz Alam. Assessment of the Phytochemical Profile, Antioxidant Capacity, and Hepatoprotective Effect of Andrographis paniculata against CCl4-Induced Liver Dysfunction in Wistar Albino Rats.
Medicina (Kaunas, Lithuania).
2023 Jul; 59(7):. doi:
10.3390/medicina59071260. [PMID: 37512069] - - Haseeb Ahsan, - Muhammad Naeem Qaisar, - Denggang Fu, - Muhammad Imran, - Muhammad Azam Tahir, - Khuram Ashfaq, - Farwa Naqvi, - Maria Manan. Hepatoprotective potential of Anagallis arvensis (L.) extract against carbon tetrachloride (CCl4)-induced hepatic injury and oxidative stress in rabbits.
Pakistan journal of pharmaceutical sciences.
2023 Jul; 36(4):1227-1232. doi:
. [PMID: 37599499] - Ru Qu, Wang Zhang, Zhuang Ma, Qianwen Ma, Mingju Chen, Tian Lan, Lin Zhou, Xuguang Hu. Glaucocalyxin A attenuates carbon tetrachloride-induced liver fibrosis and improves the associated gut microbiota imbalance.
Chemical biology & drug design.
2023 07; 102(1):51-64. doi:
10.1111/cbdd.14241. [PMID: 37060267] - Magdalena Kondeva-Burdina, Aleksandar Shkondrov, Georgi Popov, Vasil Manov, Ilina Krasteva. In Vitro/In Vivo Hepatoprotective and Antioxidant Effects of Defatted Extract and a Phenolic Fraction Obtained from Phlomis Tuberosa.
International journal of molecular sciences.
2023 Jun; 24(13):. doi:
10.3390/ijms241310631. [PMID: 37445808] - Fatima Tuj Johra, Sukria Hossain, Preeti Jain, Anika Tabassum Bristy, Tushar Emran, Rezwana Ahmed, Shazid Md Sharker, Asim Kumar Bepari, Hasan Mahmud Reza. Amelioration of CCl4-induced oxidative stress and hepatotoxicity by Ganoderma lucidum in long evans rats.
Scientific reports.
2023 Jun; 13(1):9909. doi:
10.1038/s41598-023-35228-y. [PMID: 37336915] - Samuel M Cohen, Christopher Bevan, Bhaskar Gollapudi, James E Klaunig. Evaluation of the carcinogenicity of carbon tetrachloride.
Journal of toxicology and environmental health. Part B, Critical reviews.
2023 Jun; ?(?):1-29. doi:
10.1080/10937404.2023.2220147. [PMID: 37282619] - Yun-Feng Sun, Hong-Hua Pan, Zhong-Ni Xia, Zhong-Min Yu, Cheng-Le Li, Xiao-Dong Wang, Sheng-Hui Shen. Alisma Shugan Decoction attenuates hepatic fibrosis and endoplasmic reticulum stress in mice with carbon tetrachloride-induced fibrosis.
African health sciences.
2023 Jun; 23(2):422-434. doi:
10.4314/ahs.v23i2.49. [PMID: 38223644] - Cheng Wang, Yanfang Liu, Lihong Gong, Xinyan Xue, Ke Fu, Cheng Ma, Yunxia Li. Phillygenin Ameliorates Carbon Tetrachloride-Induced Liver Fibrosis: Suppression of Inflammation and Wnt/β-Catenin Signaling Pathway.
Inflammation.
2023 May; ?(?):. doi:
10.1007/s10753-023-01826-1. [PMID: 37219693] - Yudan Wang, Xiaocui Deng, Yaping Liu, Yifen Wang, Xiaodong Luo, Tianrui Zhao, Zhengxuan Wang, Guiguang Cheng. Protective effect of Anneslea fragrans ethanolic extract against CCl4-induced liver injury by inhibiting inflammatory response, oxidative stress and apoptosis.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2023 May; 175(?):113752. doi:
10.1016/j.fct.2023.113752. [PMID: 37004906] - - Arooj Jamshaid, - Abrar Ahmed, - Fatima Rasool, - Tehreem Waheed Rana, - Mirza Nouman Amjad Baig. Study of ameliorative effect of Allium cepa essential oil and purple cabbage (Brassica Oleracea Var. Capitata F. Rubra) leaves extract on CCl4 induced nephrotoxicity in rats.
Pakistan journal of pharmaceutical sciences.
2023 May; 36(3):765-771. doi:
". [PMID: 37580924] - Xianqun Meng, Haixue Kuang, Qiuhong Wang, Hui Zhang, Dan Wang, Tingguo Kang. A polysaccharide from Codonopsis pilosula roots attenuates carbon tetrachloride-induced liver fibrosis via modulation of TLR4/NF-κB and TGF-β1/Smad3 signaling pathway.
International immunopharmacology.
2023 Apr; 119(?):110180. doi:
10.1016/j.intimp.2023.110180. [PMID: 37068337] - Changyong Lee, Sik Yoon, Jeon-Ok Moon. Kaempferol Suppresses Carbon Tetrachloride-Induced Liver Damage in Rats via the MAPKs/NF-κB and AMPK/Nrf2 Signaling Pathways.
International journal of molecular sciences.
2023 Apr; 24(8):. doi:
10.3390/ijms24086900. [PMID: 37108064] - Yan Huang, Zhi-Li Wang, Yi He, Lin-Mao Ye, Wen-Qin Guo, Jun-Jie Zhang. Jiawei Taohe Chengqi Decoction attenuates hepatic fibrosis by preventing activation of HSCs through regulating Src/ERK/Smad3 signal pathway.
Journal of ethnopharmacology.
2023 Apr; 305(?):116059. doi:
10.1016/j.jep.2022.116059. [PMID: 36549368] - Saurabh Verma, Umesh K Goand, Shivam Rathaur, Richa Garg, Roshan Katekar, Jiaur R Gayen. The combined effect of Raspberry Ketone with Resveratrol against oxidative stress and steatohepatitis in rats: Pharmacokinetic and pharmacodynamic studies.
Journal of biochemical and molecular toxicology.
2023 Apr; ?(?):e23336. doi:
10.1002/jbt.23336. [PMID: 37009719] - Bai-Lin Li, Hui-Jun Liang, Qian-Ran Li, Qian Wang, Zhuo-Yi Ao, Yu-Wen Fan, Wei-Jie Zhang, Xin Lian, Jia-Yan Chen, Jie Yuan, Jie-Wei Wu. Euryachincoside, a Novel Phenolic Glycoside with Anti-Hepatic Fibrosis Activity from Eurya chinensis.
Planta medica.
2023 Apr; 89(5):516-525. doi:
10.1055/a-1828-2671. [PMID: 35439837] - Jingshu Qi, Dabing Ping, Sun Xin, Kai Huang, Yuan Peng, Chenghai Liu. A herbal product inhibits carbon tetrachloride-induced liver fibrosis by suppressing the epidermal growth factor receptor signaling pathway.
Journal of ethnopharmacology.
2023 Mar; ?(?):116419. doi:
10.1016/j.jep.2023.116419. [PMID: 37003405] - Lijun Zhang, Chuhe Liu, Liufang Yin, Cheng Huang, Shengjie Fan. Mangiferin relieves CCl4-induced liver fibrosis in mice.
Scientific reports.
2023 Mar; 13(1):4172. doi:
10.1038/s41598-023-30582-3. [PMID: 36914687] - Vinay M Paliwal, Sourav Kundu, Uttam Kulhari, Aishwarya Jala, Sharmeen Ishteyaque, Roshan M Borkar, Madhav Nilakanth Mugale, Upadhyayula Suryanarayana Murty, Bidya Dhar Sahu. Alternanthera brasiliana L. extract alleviates carbon tetrachloride-induced liver injury and fibrotic changes in mice: Role of matrix metalloproteinases and TGF-β/Smad axis.
Journal of ethnopharmacology.
2023 Mar; 303(?):115992. doi:
10.1016/j.jep.2022.115992. [PMID: 36509261] - Erlia Anggrainy Sianipar, Jonathan An Solang, Agustina Dr Nurcahyanti, Abdi Wira Septama. Hepatoprotective and toxicological evaluation of tropical Sargassum polycystum C. Agardh collected from Sumbawa coast Indonesia, against carbon tetrachloride-induced liver damage in rats.
Pakistan journal of pharmaceutical sciences.
2023 Mar; 36(2):477-482. doi:
. [PMID: 37530155] - Shengnan Li, Rong Wang, Fuxing Song, Panpan Chen, Yanqiu Gu, Chun Chen, Yongfang Yuan. Salvianolic acid A suppresses CCl4-induced liver fibrosis through regulating the Nrf2/HO-1, NF-κB/IκBα, p38 MAPK, and JAK1/STAT3 signaling pathways.
Drug and chemical toxicology.
2023 Mar; 46(2):304-313. doi:
10.1080/01480545.2022.2028822. [PMID: 35057680] - Riffat Batool, Muhammad Rashid Khan, Muhammad Umar Ijaz, Irum Naz, Afsheen Batool, Saima Ali, Zartash Zahra, Safia Gul, Mohammad N Uddin, Mohsin Kazi, Raees Khan. Linum corymbulosum Protects Rats against CCl4-Induced Hepatic Injuries through Modulation of an Unfolded Protein Response Pathway and Pro-Inflammatory Intermediates.
Molecules (Basel, Switzerland).
2023 Feb; 28(5):. doi:
10.3390/molecules28052257. [PMID: 36903503] - Heba A Sahyon, Nagi M El-Shafai, Ibrahim El-Mehasseb, Fayez Althobaiti, Adil Aldhahrani, Noha Elnajjar. The anti-toxic effect of the date palm fruit extract loaded on chitosan nanoparticles against CCl4-induced liver fibrosis in a mouse model.
International journal of biological macromolecules.
2023 Feb; 235(?):123804. doi:
10.1016/j.ijbiomac.2023.123804. [PMID: 36842736] - Seon Been Bak, Yu Rim Song, Su-Jin Bae, Won-Yung Lee, Young Woo Kim. Integrative approach to uncover antioxidant properties of Bupleuri Radix and its active compounds: Multiscale interactome-level analysis with experimental validation.
Free radical biology & medicine.
2023 Feb; ?(?):. doi:
10.1016/j.freeradbiomed.2023.02.016. [PMID: 36841364] - Yu Song, Jiayi Wei, Rong Li, Ruifeng Fu, Pei Han, Heming Wang, Guangcong Zhang, Shuyu Li, Sinuo Chen, Zhiyong Liu, Yicheng Zhao, Changfeng Zhu, Jimin Zhu, Shuncai Zhang, Hao Pei, Jiefei Cheng, Jian Wu, Ling Dong, Guangqi Song, Xizhong Shen, Qunyan Yao. Tyrosine kinase receptor B (TrkB) attenuates liver fibrosis via inhibiting TGF-β/SMAD signaling.
Hepatology (Baltimore, Md.).
2023 02; ?(?):. doi:
10.1097/hep.0000000000000319. [PMID: 36800849] - Jianjia Huang, Yuman Bai, Wenting Xie, Rongmei Wang, Wenyue Qiu, Shuilian Zhou, Zhaoxin Tang, Jianzhao Liao, Rongsheng Su. Lyciumbarbarum polysaccharides ameliorate canine acute liver injury by reducing oxidative stress, protecting mitochondrial function, and regulating metabolic pathways.
Journal of Zhejiang University. Science. B.
2023 Feb; 24(2):157-171. doi:
10.1631/jzus.b2200213. [PMID: 36751701] - Yan Lin, Xing-Jun Chen, Jing-Jing Li, Lei He, Ya-Ru Yang, Fei Zhong, Ming-Hui He, Yi-Tong Shen, Bo Tu, Xu Zhang, Zhu Zeng. A novel type lavandulyl flavonoid from Sophora flavescens as potential anti-hepatic injury agent that inhibit TLR2/NF-κB signaling pathway.
Journal of ethnopharmacology.
2023 Feb; 307(?):116163. doi:
10.1016/j.jep.2023.116163. [PMID: 36738945] - I Bahcecı, L Tumkaya, T Mercantepe, H Yılmaz, Y E Ibık, O F Duran, N Arslan. Effects of infliximab against carbon tetrachloride-induced spleen toxicity in rats.
European review for medical and pharmacological sciences.
2023 Feb; 27(3):1140-1146. doi:
10.26355/eurrev_202302_31220. [PMID: 36808362] - Yuan-Yuan Wei, Hui-Ru Wang, Yi-Meng Fan, Jin-Hua Gu, Xiu-Ying Zhang, Xu-Hao Gong, Zhi-Hui Hao. Acute liver injury induced by carbon tetrachloride reversal by Gandankang aqueous extracts through nuclear factor erythroid 2-related factor 2 signaling pathway.
Ecotoxicology and environmental safety.
2023 Feb; 251(?):114527. doi:
10.1016/j.ecoenv.2023.114527. [PMID: 36628874] - Hatice Aysal, Nurhayat Atasoy, Ahmet Ufuk Kömüroğlu. Protective Effect of Calcium Fructoborate Against Carbon Tetrachloride-Induced Toxicity in Rats.
Biological trace element research.
2023 Feb; 201(2):800-809. doi:
10.1007/s12011-022-03202-w. [PMID: 35353337] - Fat-Moon Suk, Fang-Yu Hsu, Yi-Chieh Lee, Tzu-Lang Chen, Wan-Chun Chiu, Yi-Jen Liao. Dietary oxidized frying oil activates hepatic stellate cells and accelerates the severity of carbon tetrachloride- and thioacetamide-induced liver fibrosis in mice.
The Journal of nutritional biochemistry.
2023 Jan; 115(?):109267. doi:
10.1016/j.jnutbio.2023.109267. [PMID: 36641072] - Nuramatjan Ablat, Mihray Ablimit, Abudoureheman Abudoukadier, Buhaiqiemu Kadeer, Abulaitijiang Maihemuti, Alibati Bakewaiyi, Atike Tuerxun, Adilijiang Aihemaiti. Liver protection and hemostatic effects of medicinal plant Arnebia euchroma (Royle) I.M.Johnst extract in a rat model.
Journal of ethnopharmacology.
2023 Jan; 300(?):115739. doi:
10.1016/j.jep.2022.115739. [PMID: 36126784] - Darya Pon Kina, Sergey Kuranov, Mikhail Khvostov, Nataliya Zhukova, Yulia Meshkova, Mariya Marenina, Olga Luzina, Tatyana Tolstikova, Nariman Salakhutdinov. Hepatoprotective Effect of a New FFAR1 Agonist-N-Alkylated Isobornylamine.
Molecules (Basel, Switzerland).
2023 Jan; 28(1):. doi:
10.3390/molecules28010396. [PMID: 36615590] - Yunfei Wei, Wenxi Tan, Haiyan Qin, Meiyu Jin, Hao Yu, Jiaqi Cheng, Haihua Feng. Gomphrena globosa L. extract alleviates carbon tetrachoride-induced liver injury in mice by activating antioxidant signaling pathways and promoting autophagy.
Molecular biology reports.
2023 Jan; 50(1):97-106. doi:
10.1007/s11033-022-07942-9. [PMID: 36308582] - Jianfang Ye, Jie Chen, Yun Li, Liao Sun, Hongyun Lu. Hepatocyte-specific knockout of HIF-2α cannot alleviate carbon tetrachloride-induced liver fibrosis in mice.
PeerJ.
2023; 11(?):e15191. doi:
10.7717/peerj.15191. [PMID: 37033734] - E V Averyanova, M N Shkolnikova, O V Chugunova, O N Mazko. [Effects of triterpenoids in fatty products on liver condition of laboratory animals with acute toxic hepatitis].
Voprosy pitaniia.
2023; 92(4):81-91. doi:
10.33029/0042-8833-2023-92-4-81-91. [PMID: 37801458] - Omama E El-Shawi, Heba A S El-Nashar, Sahar S Abd El-Rahman, Omayma A Eldahshan, Abdel Nasser B Singab. Protective effect of acrocarpus fraxinifolius extract against hepatic fibrosis induced by Gamma irradiation and carbon tetrachloride in albino rats.
International journal of radiation biology.
2023; 99(2):270-280. doi:
10.1080/09553002.2022.2087926. [PMID: 35675546] - Xinyan Xue, Xingtao Zhao, Jing Wang, Cheng Wang, Cheng Ma, Yafang Zhang, Yunxia Li, Cheng Peng. Carthami flos extract against carbon tetrachloride-induced liver fibrosis via alleviating angiogenesis in mice.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2023 Jan; 108(?):154517. doi:
10.1016/j.phymed.2022.154517. [PMID: 36332390] - Ting-Ting Li, Xiao-Wei Su, Lin-Lin Chen, Wan-Nian Zhang, Jun-Ping Zhang, Yan Wang, Wei-Heng Xu. Roxarsone inhibits hepatic stellate cell activation and ameliorates liver fibrosis by blocking TGF-β1/Smad signaling pathway.
International immunopharmacology.
2023 Jan; 114(?):109527. doi:
10.1016/j.intimp.2022.109527. [PMID: 36700762] - Nayeon Yang, Myungsoon Ko, Meejung Ahn, Taekyun Shin. Hepatoprotective effects of norgalanthamine on carbon tetrachloride induced-hepatotoxicity in mice.
Drug and chemical toxicology.
2023 Jan; 46(1):144-154. doi:
10.1080/01480545.2021.2015241. [PMID: 34915776] - E S Abdel-Baky, S A Radwan, M F Ibrahim, O N Abdel-Rahman. Influence of omega- 3 fatty acids, soya isoflavones and their combination for abrogating carbon tetrachloride hazards in male rats.
Brazilian journal of biology = Revista brasleira de biologia.
2023; 84(?):e266024. doi:
10.1590/1519-6984.266024. [PMID: 36790295] - Yuangeng Li, Ping Yu, Wenwen Fu, Shuo Wang, Wenjun Zhao, Yue Ma, Yi Wu, Heming Cui, Xiaofeng Yu, Li Fu, Huali Xu, Dayun Sui. Ginsenoside Rd Inhibited Ferroptosis to Alleviate CCl4-Induced Acute Liver Injury in Mice via cGAS/STING Pathway.
The American journal of Chinese medicine.
2023; 51(1):91-105. doi:
10.1142/s0192415x23500064. [PMID: 36437551] - Congcong Zhou, Aijing Liu, Gengsong Liu, Cheng Yang, Qiaoyan Zhou, Haizhu Li, Hongchun Yang, Mengmeng Yang, Gonghe Li, Hongbin Si, Changbo Ou. Protective Effects of Sophorae tonkinensis Gagnep. (Fabaceae) Radix et Rhizoma Water Extract on Carbon Tetrachloride-Induced Acute Liver Injury.
Molecules (Basel, Switzerland).
2022 Dec; 27(24):. doi:
10.3390/molecules27248650. [PMID: 36557783] - Neelum Iqbal, Hafiz Muhammad Zubair, Mikhlid H Almutairi, Muhammad Abbas, Muhammad Furqan Akhtar, Lotfi Aleya, Mohamed Kamel, Ammara Saleem, Qaiser Jabeen, Sobia Noreen, Mirza Muhammad Faran Ashraf Baig, Mohamed M Abdel-Daim. Hepatoprotective effect of Cordia rothii extract against CCl4-induced oxidative stress via Nrf2-NFκB pathways.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Dec; 156(?):113840. doi:
10.1016/j.biopha.2022.113840. [PMID: 36252356] - Eman S Alamri, Haddad A El Rabey, Othman R Alzahrani, Fahad M Almutairi, Eman S Attia, Hala M Bayomy, Renad A Albalwi, Samar M Rezk. Enhancement of the Protective Activity of Vanillic Acid against Tetrachloro-Carbon (CCl4) Hepatotoxicity in Male Rats by the Synthesis of Silver Nanoparticles (AgNPs).
Molecules (Basel, Switzerland).
2022 Nov; 27(23):. doi:
10.3390/molecules27238308. [PMID: 36500401] - Tian-Tian Sun, Xu-Ling Liu, Guang-Yue Yang, Wei Zhang, Le Tao, Wen-Ting Ma, Liu Wu, Qigen Li, Cheng Liu. Neurotrophic factors stimulate the activation of hepatic stellate cells in liver fibrosis.
Biochemical and biophysical research communications.
2022 11; 630(?):167-174. doi:
10.1016/j.bbrc.2022.09.025. [PMID: 36155063] - Nadia Zaki Shaban, Olfat M Awad, Ghada M Fouad, Afaf M Hafez, Ahmed Alaa Abdul-Aziz, Sarah M El-Kot. Prophylactic and curative effects of Carica papaya Linn. pulp extract against carbon tetrachloride-induced hepatotoxicity in male rats.
Environmental science and pollution research international.
2022 Nov; ?(?):. doi:
10.1007/s11356-022-24083-5. [PMID: 36396758] - Qian Guo, Yi Zhang, Zhen-Lin Huang, Bin Lu, Li-Li Ji. [Effect of forsythiaside A against CCl_4-induced liver fibrosis in mice and its mechanism].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2022 Nov; 47(22):6137-6145. doi:
10.19540/j.cnki.cjcmm.20220725.401. [PMID: 36471938] - Yu-Ru Li, Ya-Fang Zhao, Guo-Liang Cheng, En-Li Wang, Yu-Jun Tan, Jing-Chun Yao, Yan Zhao, Gui-Min Zhang. [Therapeutic effect of Jingfang Granules on CCl_4-induced liver fibrosis in mice and its mechanism].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2022 Nov; 47(22):6127-6136. doi:
10.19540/j.cnki.cjcmm.20220530.402. [PMID: 36471937] - Zhangchi Sun, Xiaolan Zhan. Myrrhone inhibits the progression of hepatic fibrosis by regulating the abnormal activation of hepatic stellate cells.
Journal of biochemical and molecular toxicology.
2022 Nov; 36(11):e23177. doi:
10.1002/jbt.23177. [PMID: 35983967] - Hanan Y Aati, Mahmoud Emam, Jawaher Al-Qahtani, Sultan Aati, Abdulrahman Aati, Juergen Wanner, Mohamed M Seif. Chemical Composition of Tagetes patula Flowers Essential Oil and Hepato-Therapeutic Effect against Carbon Tetrachloride-Induced Toxicity (In-Vivo).
Molecules (Basel, Switzerland).
2022 Oct; 27(21):. doi:
10.3390/molecules27217242. [PMID: 36364067] - Yuan-Yuan Wei, Yan-Nan Zhang, Huiru Wang, Yu Ga, Yimeng Fan, Qingtao Wang, Jin-Hua Gu, Xiu-Ying Zhang, Xu-Hao Gong, Zhi-Hui Hao. Mori fructus aqueous extracts attenuate carbon tetrachloride-induced renal injury via the Nrf2 pathway and intestinal flora.
Ecotoxicology and environmental safety.
2022 Oct; 245(?):114118. doi:
10.1016/j.ecoenv.2022.114118. [PMID: 36174321] - Cheng Wang, Cheng Ma, Ke Fu, Yanfang Liu, Lihong Gong, Cheng Peng, Yunxia Li. Hepatoprotective effect of phillygenin on carbon tetrachloride-induced liver fibrosis and its effects on short chain fatty acid and bile acid metabolism.
Journal of ethnopharmacology.
2022 Oct; 296(?):115478. doi:
10.1016/j.jep.2022.115478. [PMID: 35716920] - Renye Que, Mengxing Cao, Yancheng Dai, Yi Zhou, Yirong Chen, Liubing Lin. Decursin ameliorates carbon-tetrachloride-induced liver fibrosis by facilitating ferroptosis of hepatic stellate cells.
Biochemistry and cell biology = Biochimie et biologie cellulaire.
2022 Oct; 100(5):378-386. doi:
10.1139/bcb-2022-0027. [PMID: 35785548]
